以天然分子探针为工具研究疾病机理；基于天然产物的研发新药

   

085238-生物工程

蛋白质与细胞工程
新药研发
天然产物研究与利用

1995-09--2001-05   中国科学院昆明动物研究所   博士
1991-09--1995-07   南京大学   学士

博士研究生

博士

   

2005-06~2018-06,中国科学院昆明动物研究所, 副研究员
2002-12~2005-05,瑞士伯尔尼大学, 博士后
2001-06~2002-12,中国科学院昆明动物研究所, 助理研究员

2017-12-11-今,云南中科龙津生物科技有限公司, 董事

   

（1） 蛇毒免疫排斥抑制剂－CVF研究, 三等奖, 省级, 2005
（2） 烙铁头属蛇毒结构与功能研究, 二等奖, 省级, 2004

[1] 赖仞, 龙承波, 吴飞龙, 杨敏, 吕秋敏, 李东升. 一种竹叶青PLA2蛋白特异性短肽、抗竹叶青PLA2蛋白抗体和蛇伤检测试剂盒. CN: CN113930408A, 2022-01-14.
[2] 赵敏, 赖仞, 冯颖, 吕秋敏, 张腊梅, 石雷, 何钊, 孙龙, 王成业. 喙尾琵甲提取物在化妆品中的应用. CN: CN113893214A, 2022-01-07.
[3] 赖仞, 王淦, 张旻, 李东升, 孟平, 吕秋敏. 香豆素β在制备靶向CCT4抑制TRiC活性的药物中的应用. CN: CN113876796A, 2022-01-04.
[4] 赖仞, 龙承波, 吕秋敏, 吴飞龙, 杨敏, 李东升. 一种烙铁头SVMP蛋白特异性短肽、抗烙铁头SVMP蛋白抗体和蛇伤检测试剂盒. CN: CN113832132A, 2021-12-24.
[5] 赖仞, 唐小芃, 程若梅, 吕秋敏. 检测或调控乳铁蛋白表达量的物质在制备预防和/或治疗心脑血管疾病药物或试剂盒的应用. CN: CN111879949B, 2021-11-09.
[6] 赖仞, 申传斌, 吕秋敏, 刘明, 李东升. 十八烷基化修饰的R18-7AA多肽及其衍生多肽的应用. CN: CN111870700B, 2021-10-19.
[7] 张伟, 赖仞, 段银, 吕秋敏, 文永均, 郭德文, 张治业. Sylvestin的制备方法. CN: CN112759632A, 2021-05-07.
[8] 赖仞, 申传斌, 吕秋敏, 刘明, 李东升. 十八烷基化修饰的多肽在制备抑制血小板聚集的药物中的应用. CN: CN111773376A, 2020-10-16.
[9] 赖仞, 龙承波, 余永志, 吕秋敏, 李家耀. 抗毒蛇PLA 2 蛋白抗体及其应用. CN: CN110317270A, 2019-10-11.
[10] 赖仞, 龙承波, 龙爱琳, 吕秋敏. 一种干预AD用的美洲大蠊提取物及其提取方法和应用. CN: CN108403723A, 2018-08-17.
[11] 赖仞, 刘伟慧, 龙承波, 吕秋敏. 森林山蛭抗血栓肽Sylvestin及其基因和应用. CN: CN108059672A, 2018-05-22.
[12] 赖仞, 吕秋敏, 李东升. 一种抗凝肽SYAP-1及其突变体和包括抗凝肽和/或突变体的抑制剂. CN: CN108017693A, 2018-05-11.
[13] 赖仞, 申传斌, 吕秋敏, 刘明. 3,4,7‑三羟基异黄酮或3‑甲氧基大豆素在制备抑制炎症和脑缺血药物的应用. CN: CN106860444A, 2017-06-20.
[14] 赖仞, 申传斌, 吕秋敏, 刘明. 3,4,7‑三羟基异黄酮或3‑甲氧基大豆素在制备抑制血小板聚集和血栓药物中的应用. CN: CN106822090A, 2017-06-13.
[15] 赖仞, 龙承波, 吕秋敏, 容明强. 森林山蛭镇痛肽mh2620及其基因和应用. CN: CN105732789A, 2016-07-06.
[16] 王婉瑜, 熊郁良, 孙黔云, 吕秋敏. 阵发性睡眠性血红蛋白尿症诊断试剂盒. CN: CN2648437Y, 2004-10-13.
[17] 王婉瑜, 熊郁良, 吕秋敏, 金扬, 魏勤, 魏继福, 李东升, 朱绍文. 具有生物活性的纯化多肽及其制备的用于促进动物神经细胞生长、发育以及抑制其凋亡的药物. CN: CN1346831A, 2002-05-01.
[18] 熊郁良, 王婉瑜, 孙黔云, 吕秋敏. 用于器官移植中抗超急性排斥及微量使用时提高补体活力水平的药物. CN: CN1297776A, 2001-06-06.

   

[1] Mingqian Fang, Yu Li, Zhiyi Liao, Gan Wang, Qiqi Cao, Ya Li, Yong Duan, Yanbing Han, Xinyi Deng, Feilong Wu, Peter Muiruri Kamau, Qiumin Lu, Ren Lai. Lipopolysaccharide-binding protein expression is increased by stress and inhibits monoamine synthesis to promote depressive symptoms. IMMUNITY[J]. 2023, 56(3): 620-634.e11, http://dx.doi.org/10.1016/j.immuni.2023.02.002.
[2] Ding, WeiFeng, Wang, ChengYe, Zhong, Jian, Zhang, LaMei, He, Zhao, Sun, Long, Yao, Bing, Zhang, ZhongHe, Lu, QiuMin, Zhao, Min, Feng, Ying. RNA sequencing and transcriptome analyses reveal differentially expressed genes in the defensive glands of the medicinal beetle Blaps rhynchopetera. ENTOMOLOGICAL RESEARCH[J]. 2023, 53(1): 12-28, [3] Nie, Xuekui, Chen, Qianzi, Wang, Chen, Huang, Wangxiang, Lai, Ren, Lu, Qiumin, He, Qiyi, Yu, Xiaodong. Venom Variation of Neonate and Adult Chinese Cobras in Captivity concerning Their Foraging Strategies. TOXINS[J]. 2022, 14(9): http://dx.doi.org/10.3390/toxins14090598.
[4] Meiquan Li, Xiaopeng Tang, Zhiyi Liao, Chuanbin Shen, Ruomei Cheng, Mingqian Fang, Gan Wang, Ya Li, Shuzhen Tang, Li Xie, Zhiye Zhang, Peter Muiruri Kamau, James Mwangi, Qiumin Lu, Yaxiong Li, Yuming Wang, Daniel Thomas MacKeigan, Eric G Cerenzia, Heyu Ni, Ren Lai. Hypoxia and low temperature upregulate transferrin to induce hypercoagulability at high altitude. BLOOD[J]. 2022, 140(19): 2063-2075, http://dx.doi.org/10.1182/blood.2022016410.
[5] Mingqian Fang, Xiaopeng Tang, Juan Zhang, Zhiyi Liao, Gan Wang, Ruomei Cheng, Zhiye Zhang, Hongwen Zhao, Jing Wang, Zhaoxia Tan, Peter Muiruri Kamau, Qiumin Lu, Qi Liu, Guohong Deng, Ren Lai. An inhibitor of leukotriene-A 4 hydrolase from bat salivary glands facilitates virus infection. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2022, 119(10): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915838/.
[6] Gan Wang, Min Zhang, Ping Meng, Chengbo Long, Xiaodong Luo, Xingwei Yang, Yunfei Wang, Zhiye Zhang, James Mwangi, Peter Muiruri Kamau, Zhi Daic, Zunfu Ke, Yi Zhang, Wenlin Chen, Xudong Zhao, Fei Ge, Qiumin Lv, Mingqiang Rong, Dongsheng Li, Yang Jin, Xia Sheng, Ren Lai. Anticarin-β shows a promising antiosteosarcoma effect by specifically inhibiting CCT4 to impair proteostasis. 药学学报:英文版[J]. 2022, 12(5): 2268-2279, http://lib.cqvip.com/Qikan/Article/Detail?id=7107612198.
[7] Zhang, Zhiye, Shen, Chuanbin, Fang, Mingqian, Han, Yajun, Long, Chengbo, Liu, Weihui, Yang, Min, Liu, Ming, Zhang, Dengdeng, Cao, Qiqi, Chen, Xue, Fang, Yaqun, Lu, Qiumin, Hou, Zongliu, Li, Yaxiong, Liu, Zhenze, Lei, Xi, Ni, Heyu, Lai, Ren. Novel contact-kinin inhibitor sylvestin targets thromboinflammation and ameliorates ischemic stroke. CELLULAR AND MOLECULAR LIFE SCIENCES[J]. 2022, 79(5): http://dx.doi.org/10.1007/s00018-022-04257-7.
[8] Liao, Zhiyi, Tang, Xiaopeng, Chen, Wenlin, Jiang, Xuelong, Chen, Zhongzheng, He, Kai, Li, Quan, Duan, Zilei, He, Xiaoqin, Kamau, Peter Muiruri, Lv, Longbao, Zhang, Zhiye, Rong, Mingqiang, Lv, Qiumin, Lai, Ren. Shrew's venom quickly causes circulation disorder, analgesia and hypokinesia. CELLULAR AND MOLECULAR LIFE SCIENCES[J]. 2022, 79(1): http://dx.doi.org/10.1007/s00018-021-04116-x.
[9] Long, Chengbo, Wu, Feilong, Lu, Qiumin, Xie, Bing, Shen, Chuanbin, Li, Jiayao, Deng, Yanling, Liang, Ping, Yu, Yongzhi, Lai, Ren. A Strategy for Efficient Preparation of Genus-Specific Diagnostic Antibodies for Snakebites. FRONTIERS IN IMMUNOLOGY[J]. 2021, 12: http://dx.doi.org/10.3389/fimmu.2021.775678.
[10] Xu KuanHong, Zhou Meng, Wu FeiLong, Tang XiaoPeng, Lu QiuMin, Lai Ren, Long ChengBo. Identification and characterization of a novel elastase inhibitor from Hirudinaria manillensis. CHINESE JOURNAL OF NATURAL MEDICINES[J]. 2021, 19(7): 540-544, http://dx.doi.org/10.1016/S1875-5364(21)60054-7.
[11] Ren Lai. Transferrin plays a central role in coagulation balance by interacting with clotting factors. Cell Res.. Cell Res. 2020, [12] Tang, Xiaopeng, Fang, Mingqian, Cheng, Ruomei, Zhang, Zhiye, Wang, Yuming, Shen, Chuanbin, Han, Yajun, Lu, Qiumin, Du, Yingrong, Liu, Yingying, Sun, Zhaohui, Zhu, Liping, Mwangi, James, Xue, Min, Long, Chengbo, Lai, Ren. Iron-Deficiency and Estrogen Are Associated With Ischemic Stroke by Up-Regulating Transferrin to Induce Hypercoagulability. CIRCULATIONRESEARCH[J]. 2020, 127(5): 651-663, https://www.webofscience.com/wos/woscc/full-record/WOS:000563917800010.
[13] Tian, Huiwen, Liu, Ming, Li, Jiameng, Xu, Runjia, Long, Chengbo, Li, Hao, Mwangi, James, Lu, Qiumin, Lai, Ren, Shen, Chuanbin. Snake C-Type Lectins Potentially Contribute to the Prey Immobilization in Protobothrops mucrosquamatus and Trimeresurus stejnegeri Venoms. TOXINS[J]. 2020, 12(2): https://www.webofscience.com/wos/woscc/full-record/WOS:000519117300005.
[14] Ren Lai. 14-3-3ζ-c-Src-integrin-β3 complex is vital for platelet activation. Blood. 2020, [15] Phupiewkham, Weeraya, Lu, Qiumin, Payoungkiattikun, Wisarut, Temsiripong, Threeranan, Jangpromma, Nisachon, Lai, Ren, Klaynongsruang, Sompong. Development and Characterization of an Anti-Acne Gel Containing Siamese Crocodile (Crocodylus siamensis) Leukocyte Extract. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2018, 28(5): 707-717, http://dx.doi.org/10.4014/jmb.1802.02027.
[16] Rose Ombati, Xiancui Lu, Jianmin Cui, Qiumin Lu, Longhua Zhang, Ming Zhou, Lei Luo, Changlin Tian, Sheng Wang, Shilong Yang, Fangming Wu, Ren Lai, Xiaochen Wang, Ping Liang, Junji Chen. Centipedes subdue giant prey by blocking KCNQ channels. PNAS[J]. 2018, 115(7): 1646–1651-, http://www.irgrid.ac.cn/handle/1471x/2469837.
[17] Di Wang, Ren Lai, Yang Li, Tao Xu, Chunmiao Hu, Weiheng Zhao, Xiaopeng Qi, Yan Du, Chuansheng Guo, Qiumin Lu, Chunliang Li, Gonghua Huang. Type I IFN operates pyroptosis and necroptosis during multidrug- resistant A. baumannii infection. CELL DEATH & DIFFERENTIATION[J]. 2018, *-, http://159.226.149.26:8080/handle/152453/12290.
[18] Wang, Gan, Long, Chengbo, Liu, Weihui, Xu, Cheng, Zhang, Min, Li, Qiong, Lu, Qiumin, Meng, Ping, Li, Dongsheng, Rong, Mingqiang, Sun, Zhaohui, Luo, Xiaodong, Lai, Ren. Novel Sodium Channel Inhibitor From Leeches. FRONTIERS IN PHARMACOLOGY[J]. 2018, 9(9): http://202.127.146.157/handle/2RYDP1HH/4677.
[19] Sheng, Xun, Gao, Li, Lu, Xiancui, Wang, Yunfei, Han, Yalan, Meng, Ping, Chen, Wenlin, Lu, Qiumin. Expression and characterization of a fibrinogenolytic enzyme from horsefly salivary gland. PROTEIN EXPRESSION AND PURIFICATION[J]. 2017, 129(X): 135-142, http://www.corc.org.cn/handle/1471x/2374982.
[20] He, Xiaoqin, Shen, Chuanbin, Lu, Qiumin, Li, Jiong, Wei, Yuquan, He, Li, Bai, Ruizhen, Zheng, Jie, Luan, Ning, Zhang, Zhiye, Rong, Mingqiang, Lai, Ren. Prokineticin 2 Plays a Pivotal Role in Psoriasis. EBIOMEDICINE[J]. 2016, 13(C): 248-261, http://dx.doi.org/10.1016/j.ebiom.2016.10.022.
[21] Hao, Xue, Tang, Xiaopeng, Luo, Lei, Wang, Yuming, Lai, Ren, Lu, Qiumin. A novel ranacyclin-like peptide with anti-platelet activity identified from skin secretions of the frog Amolops loloensis. GENE[J]. 2016, 576(1): 171-175, http://dx.doi.org/10.1016/j.gene.2015.10.003.
[22] Jin, Lin, Bai, Xuewei, Luan, Ning, Yao, Huimin, Zhang, Zhiye, Liu, Weihui, Chen, Yan, Yan, Xiuwen, Rong, Mingqiang, Lai, Ren, Lu, Qiumin. A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2016, 59(5): 1791-1799, http://dx.doi.org/10.1021/acs.jmedchem.5b01264.
[23] Hakim, M A, Tang XiaoPeng, Yang ShiLong, Lu QiuMin, Lai Ren. Protease inhibitor in scorpion (Mesobuthus eupeus) venom prolongs the biological activities of the crude venom. CHINESE JOURNAL OF NATURAL MEDICINES[J]. 2016, 14(8): 607-614, http://dx.doi.org/10.1016/S1875-5364(16)30071-1.
[24] Zhong, Shurong, Wu, Jianbo, Cui, Yunpeng, Li, Rui, Zhu, Shaowen, Rong, Mingqiang, Lu, Qiumin, Lai, Ren. Vascular endothelial growth factor from Trimeresurus jerdonii venom specifically binds to VEGFR-2. BIOCHIMIE[J]. 2015, 116(X): 1-7, http://dx.doi.org/10.1016/j.biochi.2015.06.011.
[25] WenBin JIANG, Ma HAKIM, Lei LUO, BoWen LI, ShiLong YANG, YuZhu SONG, Ren LAI, QiuMin LU. Purification and characterization of cholecystokinin from the skin of salamander Tylototriton verrucosus. ZOOLOGICAL RESEARCH[J]. 2015, 36(3): 174-177, http://159.226.149.42:8080:8088/handle/152453/8337.
[26] YuWei Wang, JiMin Tan, CanWei Du, Ning Luan, XiuWen Yan, Ren Lai, QiuMin Lu. A Novel Trypsin Inhibitor-Like Cysteine-Rich Peptide from the Frog Lepidobatrachus laevis Containing ProteinaseInhibiting Activity. 应用天然产物(英文)[J]. 2015, 5(4): 209-214, http://lib.cqvip.com/Qikan/Article/Detail?id=7105123155.
[27] Zhong, Yunhua, Song, Bo, Mo, Guoxiang, Yuan, Mingwei, Li, Hongli, Wang, Ping, Yuan, Minglong, Lu, Qiumin. A Novel Neurotoxin from Venom of the Spider, Brachypelma albopilosum. PLOS ONE[J]. 2014, 9(10): http://www.irgrid.ac.cn/handle/1471x/1149700.
[28] Chen, ZhongMing, Wu, JianBo, Zhang, Yong, Yang, XingWang, Yu, GuoYu, Zhu, ShaoWen, Lee, WenHui, Lu, QiuMing, Zhang, Yun. A novel platelet glycoprotein Ib-binding protein with human platelet aggregation-inhibiting activity from Trimeresurus jerdonii venom. TOXICON[J]. 2011, 57(5): 672-679, http://dx.doi.org/10.1016/j.toxicon.2011.01.010.
[29] Chen, ZhongMing, Wu, JianBo, Zhang, Yong, Yu, GuoYu, Lee, WenHui, Lu, QiuMin, Zhang, Yun. Jerdonuxin, a novel snaclec (snake C-type lectin) with platelet aggregation activity from Trimeresurus jerdonii venom. TOXICON[J]. 2011, 57(1): 109-116, http://dx.doi.org/10.1016/j.toxicon.2010.10.011.
[30] Zhang, Yong, Wu, Jianbo, Yu, Guoyu, Chen, Zhongming, Zhou, Xingding, Zhu, Shaowen, Li, Rui, Zhang, Yun, Lu, Qiumin. A novel natriuretic peptide from the cobra venom. TOXICON[J]. 2011, 57(1): 134-140, http://dx.doi.org/10.1016/j.toxicon.2010.10.014.
[31] 吕秋敏, 赖仞, 张云. 动物毒素与人类疾病——从单一成分到组学研究，从理化性质到疾病机理，从粗毒利用到理性药物设计. 动物学研究[J]. 2010, 2-16, http://lib.cqvip.com/Qikan/Article/Detail?id=32944791.
[32] 吴健波, 钟树荣, 熊郁良, 吕秋敏, 李瑞, 朱绍文, 王婉瑜. 蝰蛇C-型凝集素通过膜受体GPIb激活血小板. 第九届中国生物毒素学术研讨会null. 2009, http://www.irgrid.ac.cn/handle/1471x/1179532.
[33] Zhong, ShuRong, Jin, Yang, Wu, JianBo, Jia, YongHong, Xu, GuiLi, Wang, GenChun, Xiong, YuLiang, Lu, QiuMin. Purification and characterization of a new L-amino acid oxidase from Daboia russellii siamensis venom. TOXICON[J]. 2009, 54(6): 763-771, http://dx.doi.org/10.1016/j.toxicon.2009.06.004.
[34] 李瑞, 朱绍文, Clemetson KJ, 吴健波, 王婉瑜, 吕秋敏. 眼镜蛇蛇毒中L-氨基酸氧化酶对血小板的激活和结合作用研究. 第八届中国生物毒素学术研讨会null. 2007, http://www.irgrid.ac.cn/handle/1471x/1179537.
[35] 吴健波, 吕秋敏, 熊郁良, 金扬, 朱绍文, 王婉瑜. 菜花烙铁头蛇毒血管内皮生长因子TjsvVEGF的分离纯化与理化性质. 第八届中国生物毒素学术研讨会null. 2007, http://www.irgrid.ac.cn/handle/1471x/1179538.
[36] 吴健波, 李瑞, 吕秋敏, 朱绍文, 王婉瑜, 熊郁良. 蛇毒C-型凝集素诱导的血小板清除与体内抗血栓作用. 第八届中国生物毒素学术研讨会null. 2007, http://www.irgrid.ac.cn/handle/1471x/1179536.
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[38] 吕秋敏. Translocation of GPIb and Fc receptor gamma-chain to cytoskeleton in mucetin-activated platelets. J Thromb Haemost. 2005, [39] 陈润强, 金扬, 周兴丁, 吕秋敏, 王婉瑜, 熊郁良. 两个菜花烙铁头蛇毒金属蛋白酶去整合素基因的克隆与序列分析. 中国生物化学与分子生物学报[J]. 2004, 20(1): 6-12, http://lib.cqvip.com/Qikan/Article/Detail?id=9089648.
[40] Lu, QM, Navdaev, A, Clemetson, JM, Clemetson, KJ. GPIb is involved in platelet aggregation induced by mucetin, a snake C-type lectin protein from Chinese habu (Trimeresurus mucrosquamatus) venom. THROMBOSIS AND HAEMOSTASIS[J]. 2004, 91(6): 1168-1176, http://www.irgrid.ac.cn/handle/1471x/1149625.
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（ 1 ） 治疗耐药性真菌阴道炎化学1类新药抗菌肽ZY13临床前研究, 参与, 省级, 2015-01--2018-12
（ 2 ） 森林山蛭钠离子通道拮抗剂与通道的互作机制及镇痛作用, 主持, 省级, 2016-10--2019-09
（ 3 ） 治疗缺血性脑卒中化学1类新药ZKLJ02临床前研究, 参与, 国家级, 2018-01--2020-12
（ 4 ） 仔猪肠道物理屏障对脂肪酸代谢的影响及抗菌肽调控机制研究, 参与, 国家级, 2017-01--2021-12
（ 5 ） 治疗缺血性脑卒中的I类新药候选药物Sylvestin研究, 主持, 部委级, 2016-11--2018-06
（ 6 ） 灯盏花素作用机制研究, 主持, 院级, 2016-01--2019-12

（1）天然活性多肽与化妆品研发   2017上海化妆品科学论坛   2017-07-16
（2）节肢动物活性多肽药物研发   第一届全国昆虫产业化大会   2017-06-23

现指导学生

吴飞龙  硕士研究生  085238-生物工程  

李浩  硕士研究生  085238-生物工程