100706-药理学
100800-中药学

老年痴呆，中风，抑郁的发病机制和治疗策略
中药药理学

1998-09--2003-06   中国科学院上海药物研究所   获得博士学位

   

2007-03~现在, 中国科学院上海药物研究所, 历任助理研究员、副研究员、研究员、课题组长
2003-08~2007-03,美国Mayo Clinic研究所以及美国Wake Forest大学, 博士后、研究助理
1998-09~2003-06,中国科学院上海药物研究所, 获得博士学位

2018-06-17-2022-06-16,中国老年学学会老年医学委员会认知障碍专家委员会, 委员
2017-06-17-2022-06-16,中国药理学会抗衰老与老年痴呆专业委员会, 常务委员

神经退行性疾病发病机制和治疗策略
神经退行性疾病发病机理研究

   

（1） 赛诺菲安万特-中国科学院上海生命科学研究院优秀青年人才奖, , 研究所（学校）, 2010
（2） 中国药理学会SERVIER青年药理工作者奖, , 其他, 2010

（ 1 ） 马来酸茚达特罗在出血性脑损伤相关疾病中的应用, 2022, 第 1 作者, 专利号: CN115475165A

（ 2 ） 一种香豆素类荧光探针及其合成与应用, 2022, 第 2 作者, 专利号: CN115141170A

（ 3 ） 一类新型阿尔茨海默病检测探针及其生物应用, 2022, 第 2 作者, 专利号: CN114957296A

（ 4 ） 3-噻唑烯基氟化硼络合二吡咯甲川类化合物及其制备方法和用途, 2022, 第 2 作者, 专利号: CN112574239B

（ 5 ） 一种柏子或柏子提取物及其用途, 2021, 第 3 作者, 专利号: CN113599402A

（ 6 ） 一种乙酰胆碱酯酶抑制剂的晶型及其制备方法和应用, 2021, 第 3 作者, 专利号: CN112939846A

（ 7 ） 3-噻唑烯基氟化硼络合二吡咯甲川类化合物及其制备方法和用途, 2021, 第 2 作者, 专利号: CN112574239A

（ 8 ） N-羟基吡啶酮类化合物及其用途, 2019, 第 2 作者, 专利号: CN110536687A

（ 9 ） 二苯乙烯类化合物治疗缺血性疾病和对抗炎症反应的用途, 2019, 第 1 作者, 专利号: CN110314153A

（ 10 ） 一类苯基羧酸衍生物、其制备方法及其用途, 2019, 第 2 作者, 专利号: CN109956868A

（ 11 ） 3,4-亚甲二氧基苯基取代四氢-β-咔啉哌嗪二酮类衍生物及其用途, 2018, 第 2 作者, 专利号: CN108409738A

（ 12 ） 4-甲氧基苯基取代四氢-β-咔啉哌嗪二酮类衍生物及其应用, 2018, 第 2 作者, 专利号: CN108409737A

（ 13 ） 1,3,4-噁二唑-2-甲硫基-苯并噻唑衍生物、其制备方法和用途, 2017, 第 2 作者, 专利号: CN106916150A

（ 14 ） 荧光开关型BODIPY类化合物及其制备方法和应用, 2017, 第 2 作者, 专利号: CN106349261A

（ 15 ） 二氢-β-沉香呋喃型倍半萜类化合物、其制法和用途, 2016, 第 2 作者, 专利号: CN105712982A

（ 16 ） 取代嘧啶脲类化合物及其用途, 2016, 第 4 作者, 专利号: CN105418592A

（ 17 ） 一类具有1,2,4-恶二唑片段结构的吲哚生物碱及其制备方法和用途, 2016, 第 2 作者, 专利号: CN105272975A

（ 18 ） 一种高活性柏子提取物及其用途, 2015, 第 3 作者, 专利号: CN104367603A

（ 19 ） 石杉碱甲多晶型体、其制备方法、包含所述多晶型体的药物组合物及其用途, 2014, 第 2 作者, 专利号: CN104016918A

（ 20 ） 一类氟取代的环状胺类化合物及其制备方法、药物组合物和用途, 2014, 第 2 作者, 专利号: CN103787954A

（ 21 ） 血小板生成素在制备治疗脑血管疾病诱发的神经功能异常和认知功能障碍的药物中的用途, 2014, 第 1 作者, 专利号: CN103768581A

（ 22 ） 具有双相释药行为的石杉碱甲控释制剂及其制备方法, 2013, 第 3 作者, 专利号: CN103417505A

（ 23 ） 一种寡糖类化合物在神经保护方面的应用, 2013, 第 3 作者, 专利号: CN103340881A

（ 24 ） 咖啡酰基取代的五环三萜类衍生物及其用途, 2013, 第 2 作者, 专利号: CN103342729A

（ 25 ） 3-羟基-孕甾-21-(2′,5′-二甲氧基)苯亚甲基-5-烯-20-酮、其制备方法和用途, 2013, 第 2 作者, 专利号: CN102850424A

（ 26 ） (3R)-去-O-甲基毛狄泼老素在制备预防或治疗抑郁症的药物中的用途, 2012, 第 1 作者, 专利号: CN102716120A

（ 27 ） 石杉碱甲多晶型体、其制备方法、包含所述多晶型体的药物组合物及其用途, 2012, 第 2 作者, 专利号: CN102627605A

（ 28 ） 羟乙基三唑类化合物或氨乙基三唑类化合物及其制备方法和用途, 2012, 第 6 作者, 专利号: CN102558157A

（ 29 ） 石杉碱甲眼用微乳制剂及其制备方法, 2012, 第 2 作者, 专利号: CN102370617A

（ 30 ） 毛红椿酸甲酯及其制备方法和用途, 2012, 第 2 作者, 专利号: CN102311481A

（ 31 ） 石杉碱甲在制备治疗青光眼和/或缺血诱发的视神经损伤的药物中的用途, 2011, 第 1 作者, 专利号: CN102258518A

（ 32 ） (E)-1-(3,5-二甲氧基苯基)-2-(3,5-二羟基-4-甲氧基苯基)乙烯及其制备方法和用途, 2011, 第 4 作者, 专利号: CN102115429A

（ 33 ） 苄基哌啶类化合物及其制备方法和用途, 2009, 第 3 作者, 专利号: CN101348456A

   

（1） A novel BODIPY-based theranostic agent for in vivo fluorescence imaging of cerebral A�� and ameliorating A��-associated disorders in Alzheimer's disease transgenic mice., RSC Med Chem., 2024, 
（2） JE-133 Suppresses LPS-Induced Neuroinflammation Associated with the Regulation of JAK/STAT and Nrf2 Signaling Pathways., ACS Chem Neurosci, 2024, 
（3） Design of a Coumarin-Based Fluorescent Probe for Efficient In Vivo Imaging of Amyloid-? Plaques, ACS CHEMICAL NEUROSCIENCE, 2023, 第 8 作者  通讯作者
（4） The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression, Eur J Med Chem., 2022, 
（5） Discovery of novel dual RAGE/SERT inhibitors for the potential treatment of the comorbidity of Alzheimer's disease and depression., Eur J Med Chem., 2022, 
（6） Fused-ring ��-pyrones from intramolecular C���H activation and their lipids-lowering activity associated with LXR-IDOL-LDLR axis regulation, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 第 8 作者
（7） High-Resolution Digital Panorama of Multiple Structures in Whole Brain of Alzheimer's Disease Mice, Front Neurosci, 2022, 
（8） PDPOB Exerts Multiaspect Anti-Ischemic Effects Associated with the Regulation of PI3K/AKT and MAPK Signaling Pathways., ACS Chem Neurosci, 2021, 
（9） FPS-ZM1 inhibits LPS-induced microglial inflammation by suppressing JAK/STAT signaling pathway, Int Immunopharmacol, 2021, 
（10） Diterpenoids from the seeds of Euphorbia lathyris and their effects on microglial nitric oxide production, FITOTERAPIA, 2021, 第 6 作者  通讯作者
（11） Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer's Disease, J Med Chem, 2021, 
（12） Uncommon Diterpenoids from the South China Sea Soft Coral Sinularia humilis and Their Stereochemistry, JOURNAL OF ORGANIC CHEMISTRY, 2021, 第 4 作者
（13） Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate, JOURNAL OF MEDICINAL CHEMISTRY, 2021, 第 16 作者  通讯作者
（14） New sterols from the South China Sea sponges Halichondria sp., FITOTERAPIA, 2021, 第 4 作者
（15） An optically active isochroman-2H-chromene conjugate potently suppresses neuronal oxidative injuries associated with the PI3K/Akt and MAPK signaling pathways, An optically active isochroman-2H-chromene conjugate potently suppresses neuronal oxidative injuries associated with the PI3K/Akt and MAPK signaling pathways, ACTA PHARMACOLOGICA SINICA, 2021, 第 9 作者  通讯作者
（16） Protective Effects of 28-O-Caffeoyl Betulin (B-CA) on the Cerebral Cortex of Ischemic Rats Revealed by a NMR-Based Metabolomics Analysis, NEUROCHEMICAL RESEARCH, 2021, 第 11 作者  通讯作者
（17） Development of Novel N-hydroxypyridone Derivatives as Potential Anti-Ischemic Stroke Agents, JOURNAL OF MEDICINAL CHEMISTRY, 2020, 第 17 作者  通讯作者
（18） Development of Bisindole-Substituted Aminopyrazoles as Novel GSK-3 beta Inhibitors with Suppressive Effects against Microglial Inflammation and Oxidative Neurotoxicity, ACSCHEMICALNEUROSCIENCE, 2020, 第 6 作者  通讯作者
（19） Neuroprotective and Anti-inflammatory Ditetrahydrofuran-Containing Diarylheptanoids from Tacca chantrieri, JOURNAL OF NATURAL PRODUCTS, 2020, 第 7 作者
（20） Repurposing antimycotic ciclopirox olamine as a promising anti-ischemic stroke agent, ACTA PHARMACEUTICA SINICA B, 2020, 第 13 作者  通讯作者
（21） advancesinthedevelopmentofimagingprobesandaggregationinhibitorsforalphasynuclein, ACTA PHARMACOLOGICA SINICA, 2020, 第 5 作者
（22） 1,5-Hydride Shift-Cyclization versus C(sp 2 )-H Functionalization in the Knoevenagel-Cyclization Domino Reactions of 1,4- and 1,5-Benzoxazepines, MOLECULES, 2020, 第 11 作者
（23） Development of Novel N-hydroxypyridone Derivatives as Potential Anti-Ischemic Stroke Agents., J Med Chem., 2020, 
（24） Interplay between Alzheimer's disease and global glucose metabolism revealed by the metabolic profile alterations of pancreatic tissue and serum in APP/PS1 transgenic mice, Acta Pharmacol Sin., 2019, 
（25） Fluorescence Imaging of Alzheimer's Disease with a Flat Ensemble Formed between a Quinoline-Malononitrile AIEgen and Thin-Layer Molybdenum Disulfide, CHEMBIOCHEM, 2019, 第 7 作者  通讯作者
（26） Neuroprotective Effect of Natural Alkaloid Fangchinoline Against Oxidative Glutamate Toxicity: Involvement of Keap1-Nrf2 Axis Regulation., Cell Mol Neurobiol., 2019, 
（27） Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer's Disease Agents, ACS CHEMICAL NEUROSCIENCE, 2019, 第 9 作者  通讯作者
（28） Neuroprotective Effect of Natural Alkaloid Fangchinoline Against Oxidative Glutamate Toxicity: Involvement of Keap1-Nrf2 Axis Regulation, CELLULAR AND MOLECULAR NEUROBIOLOGY, 2019, 第 3 作者  通讯作者
（29） Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression, Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression, CELL RESEARCH, 2019, 第 22 作者
（30） Rational Design of Near-Infrared Aggregation-Induced-Emission Active Probes: In Situ Mapping of Annyloid-beta Plaques with Ultrasensitivity and High-Fidelity, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019, 第 5 作者  通讯作者
（31） A11, a novel diaryl acylhydrazone derivative, exerts neuroprotection against ischemic injury in vitro and in vivo, a11anoveldiarylacylhydrazonederivativeexertsneuroprotectionagainstischemicinjuryinvitroandinvivo, ACTA PHARMACOLOGICA SINICA, 2019, 第 5 作者  通讯作者
（32） Neuroprotective Dihydro-beta-agarofuran-Type Sesquiterpenes from the Seeds of Euonymus maackii, JOURNAL OF NATURAL PRODUCTS, 2019, 第 4 作者  通讯作者
（33） Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their acetylcholinesterase inhibitory activity, FITOTERAPIA, 2019, 第 10 作者
（34） Interplay between Alzheimer’s disease and global glucose metabolism revealed by the metabolic profile alterations of pancreatic tissue and serum in APP/PS1 transgenic mice, Interplay between Alzheimer's disease and global glucose metabolism revealed by the metabolic profile alterations of pancreatic tissue and serum in APP/PS1 transgenic mice, ACTA PHARMACOLOGICA SINICA, 2019, 第 4 作者  通讯作者
（35） Lycofargesiines A���F, further Lycopodium alkaloids from the club moss Huperzia fargesii, PHYTOCHEMISTRY, 2019, 第 3 作者  通讯作者
（36） Reconsideration of Anticholinesterase Therapeutic Strategies against Alzheimer's Disease, ACS CHEMICAL NEUROSCIENCE, 2019, 第 2 作者  通讯作者
（37） Iron dysregulates APP processing accompanying with sAPP alpha cellular retention and beta-secretase inhibition in rat cortical neurons, ACTA PHARMACOLOGICA SINICA, 2018, 第 5 作者  通讯作者
（38） Fluorescent Imaging of beta-Amyloid Using BODIPY Based Near-Infrared Off-On Fluorescent Probe, BIOCONJUGATE CHEMISTRY, 2018, 第 9 作者  通讯作者
（39） Iron-induced energy supply deficiency and mitochondrial fragmentation in neurons, JOURNAL OF NEUROCHEMISTRY, 2018, 第 6 作者  通讯作者
（40） HPLC-ECD and TDDFT-ECD study of hexahydropyrrolo1,2-aquinoline derivatives, CHIRALITY, 2018, 第 8 作者
（41） Acetophenone derivatives from the root bark of Cynanchum wilfordii as potential neuroprotective agents, PHYTOCHEMISTRY LETTERS, 2018, 第 11 作者  通讯作者
（42） Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetyicholinesterase (AChE) and Phosphodiesterase 5 (PDE5), ACS CHEMICAL NEUROSCIENCE, 2018, 第 10 作者  通讯作者
（43） Iron dysregulates APP processing accompanying with sAPPa cellular retention and ��-secretase inhibition in rat cortical neurons, ACTA PHARMACOLOGICA SINICA, 2018, 第 5 作者
（44） Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment, BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 第 11 作者  通讯作者
（45） Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 第 11 作者  通讯作者
（46） Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease, ACS CHEMICAL NEUROSCIENCE, 2018, 第 10 作者  通讯作者
（47） Novel Vilazodone Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation, ACS CHEMICAL NEUROSCIENCE, 2017, 第 10 作者  通讯作者
（48） Dual anti-ischemic effects of rosmarinic acid n -butyl ester via alleviation of DAPK-p53-mediated neuronal damage and microglial inflammation, ACTA PHARMACOLOGICA SINICA, 2017, 第 6 作者  通讯作者
（49） Annotinolide F and lycoannotines A���I, further Lycopodium alkaloids from Lycopodium annotinum, PHYTOCHEMISTRY, 2017, 第 6 作者
（50） Synthesis and biological evaluation of benzothiazol-based 1,3,4-oxadiazole derivatives as amyloid beta-targeted compounds against Alzheimer's disease, MONATSHEFTE FUR CHEMIE, 2017, 第 7 作者  通讯作者
（51） D-A-D fluorogenic probe for the rapid imaging of amyloid beta plaques in vivo, DYES AND PIGMENTS, 2017, 第 4 作者  通讯作者
（52） Taxodikaloids A and B, Two Dimeric Abietane-Type Diterpenoids from Taxodium ascendens Possessing an Oxazoline Ring Linkage, ORGANIC LETTERS, 2017, 第 5 作者
（53） Acetylcholinesterase-independent protective effects of huperzine A against iron overload-induced oxidative damage and aberrant iron metabolism signaling in rat cortical neurons, ACTA PHARMACOLOGICA SINICA, 2016, 第 5 作者  通讯作者
（54） Discovery of a novel fluorescent probe for the sensitive detection of ��-amyloid deposits, BIOSENSORS AND BIOELECTRONICS, 2016, 第 9 作者
（55） Metabolomic investigation of regional brain tissue dysfunctions induced by global cerebral ischemia, BMC NEUROSCIENCE, 2016, 第 5 作者  通讯作者
（56） Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer Agents, JOURNAL OF MEDICINAL CHEMISTRY, 2016, 第 11 作者
（57） Phlefargesiine A, a C16N2Lycopodium alkaloid with an unprecedented 6/7/6/6-tetracyclic skeleton from Phlegmariurus fargesii, TETRAHEDRON LETTERS, 2016, 第 4 作者
（58） Biginkgosides A-I, Unexpected Minor Dimeric Flavonol Diglycosidic Truxinate and Truxillate Esters from Ginkgo biloba Leaves and Their Antineuroinflammatory and Neuroprotective Activities, JOURNAL OF NATURAL PRODUCTS, 2016, 第 9 作者  通讯作者
（59） Chemical Constituents from the Fermented Mycelia of the Medicinal Fungus Xylaria nigripes, HELVETICA CHIMICA ACTA, 2016, 第 9 作者
（60） Advances in development of fluorescent probes for detecting amyloid-β aggregates, advancesindevelopmentoffluorescentprobesfordetectingamyloidaggregates, ACTAPHARMACOLOGICASINICA, 2016, 第 5 作者
（61） Annotinolides A-C, Three Lycopodane-Derived 8,5-Lactones with Polycyclic Skeletons from Lycopodium annotinum, ORGANIC LETTERS, 2016, 第 5 作者  通讯作者
（62） Lycopodium alkaloids from Lycopodium obscurum L. f. strictum, PHYTOCHEMISTRY LETTERS, 2016, 第 4 作者  通讯作者
（63） Design, synthesis and biological evaluation of novel chiral oxazino-indoles as potential and selective neuroprotective agents against A beta(25-35)-induced neuronal damage, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 第 7 作者  通讯作者
（64） Discovery of a novel fluorescent probe for the sensitive detection of beta-amyloid deposits, BIOSENSORS & BIOELECTRONICS, 2016, 第 9 作者
（65） Palhicerines A���F, Lycopodium alkaloids from the club moss Palhinhaea cernua, PHYTOCHEMISTRY, 2016, 第 4 作者
（66） Caffeoyl Triterpenoid Esters as Potential Anti-ischemic Stroke Agents from Celastrus orbiculatus, JOURNAL OF NATURAL PRODUCTS, 2016, 第 8 作者  通讯作者
（67） Advances in development of fluorescent probes for detecting amyloid-beta aggregates, ACTA PHARMACOLOGICA SINICA, 2016, 第 5 作者  通讯作者
（68） A novel caffeoyl triterpene attenuates cerebral ischemic injury with potent anti-inflammatory and hypothermic effects, JOURNAL OF NEUROCHEMISTRY, 2015, 第 11 作者  通讯作者
（69） Synthesis and biological evaluation of novel marine-derived indole-based 1,2,4-oxadiazoles derivatives as multifunctional neuroprotective agents, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 第 7 作者
（70） Involvement of Intracellular and Mitochondrial A�� in the Ameliorative Effects of Huperzine A against Oligomeric A�� 42 -Induced Injury in Primary Rat Neurons, PLOS ONE, 2015, 第 8 作者
（71） Donepezil attenuates A beta-associated mitochondrial dysfunction and reduces mitochondrial A beta accumulation in vivo and in vitro, NEUROPHARMACOLOGY, 2015, 第 4 作者  通讯作者
（72） Involvement of Intracellular and Mitochondrial A beta in the Ameliorative Effects of Huperzine A against Oligomeric A beta(42)-Induced Injury in Primary Rat Neurons, PLOS ONE, 2015, 第 8 作者  通讯作者
（73） Two new humulanolides from the roots of Cynanchum wilfordii, TETRAHEDRON LETTERS, 2015, 第 3 作者
（74） Bioactive constituents from the green alga Caulerpa racemosa, BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 第 5 作者
（75） Natural beta-Dihydroagarofuran-Type Sesquiterpenoids as Cognition-Enhancing and Neuroprotective Agents from Medicinal Plants of the Genus Celastrus, JOURNAL OF NATURAL PRODUCTS, 2015, 第 8 作者  通讯作者
（76） Long-Term Vision and Non-Vision Dominant Behavioral Deficits in the 2-VO Rats Are Accompanied by Time and Regional Glial Activation in the White Matter, PLOS ONE, 2014, 第 6 作者  通讯作者
（77） Dysregulation of neurotrophic and inflammatory systems accompanied by decreased CREB signaling in ischemic rat retina, EXPERIMENTAL EYE RESEARCH, 2014, 第 8 作者  通讯作者
（78） Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease, NEUROBIOLOGY OF AGING, 2014, 第 9 作者
（79） Two New Limonoids from the Root Bark of Chinese Medicinal Plant Dictamnus dasycarpus, HELVETICA CHIMICA ACTA, 2014, 第 6 作者
（80） Preparation of neuroprotective condensed 1,4-benzoxazepines by regio- and diastereoselective domino Knoevenagel���1,5-hydride shift cyclization reaction, BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2014, 第 3 作者
（81） Quantitative proteomic analysis reveals the neuroprotective effects of huperzine A for amyloid beta treated neuroblastoma N2a cells, PROTEOMICS, 2013, 第 6 作者  通讯作者
（82） Discovery of pyrazole as C-terminus of selective BACE1 inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 第 13 作者  通讯作者
（83） Discovery of novel 2,6-disubstituted pyridazinone derivatives asacetylcholinesterase inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 第 5 作者  通讯作者
（84） (M)- and (P)-Bicelaphanol A, Dimeric Trinorditerpenes with Promising Neuroprotective Activity from Celastrus orbiculatus, JOURNAL OF NATURAL PRODUCTS, 2013, 第 9 作者  通讯作者
（85） Alternations of central insulin-like growth factor-1 sensitivity in APP/PS1 transgenic mice and neuronal models, JOURNAL OF NEUROSCIENCE RESEARCH, 2013, 第 3 作者  通讯作者
（86） Ac-cel, a Novel Antioxidant, Protects Against Hydrogen Peroxide-induced Injury in PC12 Cells via Attenuation of Mitochondrial Dysfunction, JOURNAL OF MOLECULAR NEUROSCIENCE, 2013, 第 8 作者
（87） Promising effects on ameliorating mitochondrial function and enhancing Akt signaling in SH-SY5Y cells by (M)-bicelaphanol A, a novel dimeric podocarpane type trinorditerpene isolated from Celastrus orbiculatus, PHYTOMEDICINE, 2013, 第 7 作者
（88） Casuarinines A-J, Lycodine-Type Alkaloids from Lycopodiastrum casuarinoides, JOURNAL OF NATURAL PRODUCTS, 2013, 第 9 作者
（89） Racemosins A and B, two novel bisindole alkaloids from the green alga Caulerpa racemosa, FITOTERAPIA, 2013, 第 3 作者
（90） Bioactive polyhydroxylated steroids from the Hainan soft coral Sinularia depressa Tixier-Durivault, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 第 3 作者
（91） S-52, a novel nootropic compound, protects against beta-amyloid induced neuronal injury by attenuating mitochondrial dysfunction, JOURNAL OF NEUROSCIENCE RESEARCH, 2012, 第 5 作者  通讯作者
（92） Yalongenes A and B, Two New Cembranoids with Cytoprotective Effects from the Hainan Soft Coral Sarcophyton trocheliophorum Marenzeller, HELVETICA CHIMICA ACTA, 2012, 第 2 作者
（93） New insights into huperzine A for the treatment of Alzheimer's disease, ACTA PHARMACOLOGICA SINICA, 2012, 第 1 作者  通讯作者
（94） Synthesis and biological evaluation of 21-arylidenepregnenolone derivatives as neuroprotective agents, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 第 5 作者  通讯作者
（95） Dibenzocyclooctadiene Lignans from Kadsura polysperma and Their Antineurodegenerative Activities, JOURNAL OF NATURAL PRODUCTS, 2012, 第 3 作者
（96） Development of Cell-Active N-6-Methyladenosine RNA Demethylase FTO Inhibitor, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 第 17 作者
（97） Morusalbanol A, a neuro-protective Diels���Alder adduct with an unprecedented architecture from Morus alba, TETRAHEDRON, 2012, 第 6 作者
（98） Decreased Accumulation of Subcellular Amyloid-beta with Improved Mitochondrial Function Mediates the Neuroprotective Effect of Huperzine A, JOURNAL OF ALZHEIMERS DISEASE, 2012, 第 5 作者  通讯作者
（99） Huperzine A Alleviates Synaptic Deficits and Modulates Amyloidogenic and Nonamyloidogenic Pathways in APPswe/PS1dE9 Transgenic Mice, JOURNAL OF NEUROSCIENCE RESEARCH, 2012, 第 3 作者  通讯作者
（100） Protolimonoids and norlimonoids from the stem bark of Toona ciliata var. pubescens, ORGANIC & BIOMOLECULAR CHEMISTRY, 2011, 第 7 作者
（101） New dibenzocyclooctadiene lignans from the Kadsura ananosma, TETRAHEDRON, 2011, 第 2 作者
（102） T33, a novel peroxisome proliferator-activated receptor gamma/alpha agonist, exerts neuroprotective action via its anti-inflammatory activities, ACTA PHARMACOLOGICA SINICA, 2011, 第 4 作者  通讯作者
（103） Huperzine A Improves Chronic Inflammation and Cognitive Decline in Rats With Cerebral Hypoperfusion, JOURNAL OF NEUROSCIENCE RESEARCH, 2010, 第 2 作者  通讯作者
（104） Retrospect and prospect of active principles from Chinese herbs in the treatment of dementia, ACTA PHARMACOLOGICA SINICA, 2010, 第 4 作者  通讯作者
（105） Phenolic compounds with cell protective activity from the fruits of Livistona chinensis, JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2009, 第 3 作者
（106） Novel 16-substituted bifunctional derivatives of huperzine B: multifunctional cholinesterase inhibitors, ACTA PHARMACOLOGICA SINICA, 2009, 第 2 作者  通讯作者
（107） Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment, ACTA PHARMACOLOGICA SINICA, 2009, 第 2 作者
（108） Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide, FREE RADICAL BIOLOGY AND MEDICINE, 2009, 第 5 作者
（109） Discovery of potent beta-secretase (bace-1) inhibitors by the synthesis of isophthalamide-containing hybrids, ACTA PHARMACOLOGICA SINICA, 2009, 第 6 作者
（110） Discovery of potent β-secretase (bace-1) inhibitors by the synthesis of isophthalamide-containing hybrids, discoveryofpotentsecretasebace1inhibitorsbythesynthesisofisophthalamidecontaininghybrids, ACTAPHARMACOLOGICASINICA, 2009, 第 6 作者
（111） Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and beta-secretase, BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 第 15 作者  通讯作者
（112） Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia, CHEMICO-BIOLOGICAL INTERACTIONS, 2008, 第 1 作者
（113） Huperzine A attenuates mitochondrial dysfunction after middle cerebral artery occlusion in rats, JOURNAL OF NEUROSCIENCE RESEARCH, 2008, 第 2 作者  通讯作者
（114） Huperzine A exhibits anti-inflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia, JOURNAL OF NEUROCHEMISTRY, 2008, 第 3 作者  通讯作者
（115） Non-cholinergic effects of huperzine A: Beyond inhibition of acetylcholinesterase, CELLULAR AND MOLECULAR NEUROBIOLOGY, 2008, 第 1 作者
（116） Studies of natural products on treating neurological disorders in China, CELLULAR AND MOLECULAR NEUROBIOLOGY, 2008, 第 1 作者
（117） Involvement of MI-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-alpha, NEUROREPORT, 2007, 第 2 作者
（118） Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease, TRENDS IN PHARMACOLOGICAL SCIENCES, 2006, 第 1 作者
（119） Apoptosis induced by β-amyloid25-35 in acetylcholinesteraseoverexpressing neuroblastoma cells, apoptosisinducedbyamyloid2535inacetylcholinesteraseoverexpressingneuroblastomacells, ACTAPHARMACOLOGICASINICA, 2003, 第 1 作者

   

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