基本信息
孙钦秒  女  博导  中国科学院动物研究所
电子邮件: qinmiaosun@ioz.ac.cn
通信地址: 北京朝阳区大屯路甲3号干细胞创新研究院
邮政编码: 100101

招生信息

   
招生专业
071009-细胞生物学
071010-生物化学与分子生物学
071008-发育生物学
招生方向
天然免疫,干细胞
癌症生物学
干细胞

教育背景

1996-09--1999-07   中国科学院植物研究所   博士
1993-09--1996-07   山东农业大学   硕士
1989-09--1993-07   山东农业大学   学士

工作经历

   
工作简历
2007-12~现在, 中国科学院动物研究所, 研究员
2006-01~2007-12,美国德州西南医学中心, 讲师
2001-12~2005-12,美国德州西南医学中心, 博士后
2000-02~2000-11,美国肯塔基大学, 博士后
1996-09~1999-07,中国科学院植物研究所, 博士
1993-09~1996-07,山东农业大学, 硕士
1989-09~1993-07,山东农业大学, 学士

教授课程

分子细胞生物学
感染免疫学
细胞免疫学

专利与奖励

   
专利成果
( 1 ) 用于诱导多能干细胞的融合蛋白及其使用方法, 2014, 第 3 作者, 专利号: CN103739718A

出版信息

   
发表论文
(1) PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation, Nature Communications, 2022, 通讯作者
(2) Dynamic FMR1 granule phase switch instructed by m6A modification contributes to maternal RNA decay, Nature Communications, 2022, 通讯作者
(3) KIZ/GM114 Balances the NF-ĸB Signaling by Antagonizing the Association of TRAF2/6 With Their Upstream Adaptors, Frontiers in Cell and Developmental Biology, 2022, 通讯作者
(4) Lipid mediated–phase separation of AGO proteins on ER controls nascent peptide ubiquitination, Mol Cell, 2022, 通讯作者
(5) ZDHHC11 Positively Regulates NF-κB Activation by Enhancing TRAF6 Oligomerization, Frontiers in Cell and Developmental Biology, 2021, 通讯作者
(6) USP27X negatively regulates antiviral signaling by deubiquitinating RIG-I, PLOS PATHOGENS, 2020, 通讯作者
(7) LC Domain-Mediated Coalescence Is Essential for Otu Enzymatic Activity to Extend Drosophila Lifespan, MOLECULAR CELL, 2019, 通讯作者
(8) 6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda, Nature Communications, 2019, 通讯作者
(9) Parkin negatively regulates the antiviral signaling pathway by targeting TRAF3 for degradation, JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 通讯作者
(10) Partial loss of psychiatric risk gene miR-137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a, NATURE NEUROSCIENCE, 2018, 
(11) Bam-dependent deubiquitinase complex can disrupt germ-line stem cell maintenance by targeting cyclin A, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 通讯作者
(12) Bam-Dependent Deubiquitinase Complex Can Disrupt Germ-Line Stem Cell Maintenance by Targeting Cyclin A, PNAS, 2017, 第 9 作者
(13) Membrane Targeting of Inhibitory Smads Through Palmitoylation Controls TGF-β/BMP Signaling, PNAS, 2017, 第 8 作者
(14) Membrane targeting of inhibitory Smads through palmitoylation controls TGF-beta/BMP signaling, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 通讯作者
(15) Syndecan-4 negatively regulates antiviral signaling by mediating RIG-I deubiquitination via CYLD, Nature Communications, 2016, 通讯作者
(16) Identification of miRNomes Reveals ssc-miR-30d-R_1 as a Potential Therapeutic Target for PRRS Viral Infection, SCIENTIFIC REPORTS, 2016, 第11作者
(17) Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD., NATURE COMMUNICATIONS, 2016, 通讯作者
(18) MAVS Maintains Mitochondrial Homeostasis via Autophagy, CELL DISCOVERY, 2016, 通讯作者
(19) Critical POU Domain Residues Confer Oct4 Uniqueness in Somatic Cell Reprogramming, SCIENTIFIC REPORTS, 2016, 通讯作者
(20) N6-Methyladenine Functions as a Potential Epigenetic Mark in Eukaryotes, BIOESSAYS, 2015, 通讯作者
(21) PPM1A Regulates Antiviral Signaling by Antagonizing TBK1-Mediated STING Phosphorylation and Aggregation, Public Library of Science, 2015, 
(22) Stucturally Diverse Sesquiterpenes Produced by a Chinese Tibet Fungus Stereum hirsutum and Their Cytotoxic and Immunosuppressant Activities, ORGANIC LETTERS, 2015, 第 7 作者
(23) Cell-surface localization of Pellino antagonizes Toll-mediated innate immune signaling by controlling MyD88 turnover in Drosophila., Nature Communicaitons, 2014, 通讯作者
(24) Coordination of Engineered Factors with TET1/2 Promotes Early-Stage Epigenetic Modification during Somatic Cell Reprogramming, STEM CELL REPORTS, 2014, 通讯作者
(25) Coordination of engineered factors with TET 1/2 promotes the early stage epigenetic modification during somatic cell reprogramming., Stem Cell Reports, 2014, 通讯作者
(26) Cell-Surface Localization of Pellino Antagonizes Toll-Mediated Innate Immune Signalling by Controlling MyD88 Turnover in Drosophila, NATURE COMMUNICATIONS, 2014, 通讯作者
(27) Genome-Wide Loss of 5-hmC Is a Novel Epigenetic Feature of Huntingtons Disease, HUMAN MOLECULAR GENETICS, 2013, 第 10 作者
(28) Dysregulation of Mitochondrial Calcium Signaling and Superoxide Flashes Cause Mitochondrial Genomic DNA Damage in Huntington Disease, JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 第 8 作者
(29) COX5B Regulates MAVS-mediated Antiviral Signaling through Interaction with ATG5 and Repressing ROS Production, PLOS PATHOGENS, 2012, 第 7 作者
(30) The Fused/Smurf Complex Controls the Fate of Drosophila Germline Stem Cells by Generating a Gradient BMP Response, CELL, 2010, 第11作者
(31) Murine Gamma-Herpesvirus 68 Hijacks MAVS and IKK beta to Initiate Lytic Replication, PLOS PATHOGENS, 2010, 第 3 作者

科研活动

   
科研项目
( 1 ) 胸腺与免疫细胞发育的分子调控, 负责人, 国家任务, 2010-01--2014-12
( 2 ) 原始生殖细胞特化和定向迁移, 参与, 国家任务, 2013-01--2017-12
( 3 ) 线粒体电子传递链组分COX5B与自噬途径协同调控MAVS介导的抗病毒天然免疫反应的分子机制, 负责人, 国家任务, 2014-01--2017-12
( 4 ) E3泛素连接酶调控Toll信号介导的天然免疫反应分子机制的研究, 负责人, 国家任务, 2016-01--2019-12
( 5 ) 新型表观遗传修饰体系的鉴定及机制研究, 负责人, 国家任务, 2016-07--2020-12
( 6 ) 高原环境(低氧)下DNA修饰的表观遗传调控, 参与, 中国科学院计划, 2017-05--2019-06
( 7 ) 原始生殖细胞的命运决定、迁移和归巢机制, 参与, 国家任务, 2018-12--2021-12
( 8 ) 去泛素相关蛋白Gm114在肠道稳态和炎症反应调控机制的研究, 负责人, 国家任务, 2020-01--2023-12
( 9 ) 果蝇和线虫发育代谢资源库的系统构建与分析, 负责人, 国家任务, 2021-12--2026-11