071008-发育生物学

性别决定,性腺发育,配子发生

   

2007-10~现在, 中国科学院动物研究所, 研究员/博士

生殖生物学
现代生殖医学之病理概论
现代生殖医学之生理基础
胚胎工程
生殖生理学
生殖疾病概论
发育生物学专业研讨课

   

（1） 全国妇幼健康科学技术奖, 一等奖, 部委级, 2021

   

（1） CCDC189 affects sperm flagellum formation by interacting with CABCOCO1, NATIONAL SCIENCE REVIEW, 2023, 第 8 作者
（2） Wt1基因在小鼠性腺发育和体细胞分化过程中的作用, The functions of Wt1 gene in mouse gonad development and gonadal somatic cell differentiation, 遵义医科大学学报, 2023, 第 2 作者
（3） Infection of SARS-CoV-2 causes severe pathological changes in mouse testis, J Genet Genomics, 2022, 第 11 作者  通讯作者
（4） A single-nucleus transcriptomic atlas of primate testicular aging reveals exhaustion of the spermatogonial stem cell reservoir and loss of Sertoli cell homeostasis, Protein & Cell, 2022, 第 12 作者
（5） PRMT5 regulates ovarian follicle development by facilitating Wt1 translation, ELIFE, 2021, 第 9 作者  通讯作者
（6） PRMT5 Is Involved in Spermatogonial Stem Cells Maintenance by Regulating Plzf Expression via Modulation of Lysine Histone Modifications, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 第 9 作者  通讯作者
（7） Absence of murine CFAP61 causes male infertility due to multiple morphological abnormalities of the flagella, SCIENCE BULLETIN, 2020, 第 9 作者
（8） Tracing the origin of the placental trophoblast cells in mouse embryo development, BIOLOGY OF REPRODUCTION, 2020, 第 6 作者  通讯作者
（9） Effects of Different Biomaterials and Cellular Status on Testicular Cell Self-Organization, ADVANCED BIOSYSTEMS, 2020, 第 7 作者  通讯作者
（10） 小鼠性别决定过程中性腺体细胞分化的调控, The regulation of gonadal somatic cell differentiation during sex determination in mice, 生理学报, 2020, 第 5 作者
（11） PRMT7 is involved in regulation of germ cell proliferation during embryonic stage, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 第 7 作者  通讯作者
（12） Brain-specific Wt1 deletion leads to depressive-like behaviors in mice via the recruitment of Tet2 to modulate Epo expression, MOLECULAR PSYCHIATRY, 2020, 第 4 作者
（13） Inactivation of Wt1 causes pre-granulosa cell to steroidogenic cell transformation and defect of ovary development, BIOLOGY OF REPRODUCTION, 2020, 第 8 作者  通讯作者
（14） Loss of GM130 does not impair oocyte meiosis and embryo development in mice, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 第 9 作者  通讯作者
（15） WDR62 is involved in spindle assembly by interacting with CEP170 in spermatogenesis, DEVELOPMENT, 2019, 第 13 作者  通讯作者
（16） Mir223 restrains autophagy and promotes CNS inflammation by targeting ATG16L1, AUTOPHAGY, 2019, 第 17 作者
（17） 九香虫水提液对锰中毒大鼠睾丸损伤的抗凋亡作用, Anti-apoptotic function of Coridius chinensis extracts on testicular damage induced by manganese in rats, 遵义医科大学学报, 2019, 第 5 作者
（18） The HMGA2-IMP2 Pathway Promotes Granulosa Cell Proliferation in Polycystic Ovary Syndrome, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2019, 第 9 作者
（19） Abnormal Meiosis Initiation in Germ Cell Caused by Aberrant Differentiation of Gonad Somatic Cell, OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2019, 第 8 作者  通讯作者
（20） RNA-Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator in Early Zygotic Genome Activation, ADVANCED SCIENCE, 2019, 第 18 作者
（21） Wilms' Tumor 1 Overexpression in Granulosa Cells Is Associated with Polycystic Ovaries in Polycystic Ovary Syndrome Patients, GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 2018, 第 7 作者
（22） Wdr62 is involved in meiotic initiation via activating JNK signaling and associated with POI in humans, PLOS GENETICS, 2018, 第 16 作者  通讯作者
（23） 九香虫对锰暴露雄性大鼠体内锰分布的影响, Effects of Coridiuschinensis on manganese distribution in male rats exposed to manganese, 遵义医学院学报, 2018, 第 5 作者
（24） Wdr62 is involved in female meiotic initiation via activating JNK signaling and associated with POI in humans., PLOS GENETICS, 2018, 第 15 作者
（25） 关于繁殖力与寿命反向运动关系的讨论, Inverse kinematics of lifespan and fecundity, 医学争鸣, 2018, 第 6 作者
（26） cTAGE5/MEA6 plays a critical role in neuronal cellular components trafficking and brain development, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 第 16 作者
（27） Autophagy regulates testosterone synthesis by facilitating cholesterol uptake in Leydig cells, JOURNAL OF CELL BIOLOGY, 2018, 第 13 作者
（28） Loss of the golgin GM130 causes Golgi disruption, Purkinje neuron loss, and ataxia in mice, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 第 7 作者
（29） CTAGE5 Deletion in Pancreatic �� Cells Impairs Proinsulin Trafficking and Insulin Biogenesis in Mice, JOURNAL OF CELL BIOLOGY, 2017, 第 8 作者
（30） Sirt1 Regulates Acrosome Biogenesis by Modulating Autophagic Flux During Spermiogenesis in Mice, DEVELOPMENT, 2017, 第 14 作者
（31） Essential Role for SUN5 in Anchoring Sperm Head to the Tail, ELIFE, 2017, 第 15 作者  通讯作者
（32） cTAGE5 deletion in pancreatic beta cells impairs proinsulin trafficking and insulin biogenesis in mice, JOURNAL OF CELL BIOLOGY, 2017, 第 8 作者
（33） BCAS2 Is Involved in Alternative mRNA Splicing in Spermatogonia and the Transition to Meiosis, NATURE COMMUNICATIONS, 2017, 第 11 作者
（34） Globozoospermia and Lack of Acrosome Formation in GM130-Deficient Mice, CELL DEATH & DISEASE, 2017, 第 12 作者  通讯作者
（35） beta-Catenin directs the transformation of testis Sertoli cells to ovarian granulosa-like cells by inducing Foxl2 expression, JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 第 11 作者  通讯作者
（36） Loss of the Golgin GM130 Causes Golgi Disruption, Purkinje Neuron Loss, and Ataxia in Mice, PNAS, 2017, 第 7 作者
（37） The role of fructose-1,6-bisphosphatase 1 in abnormal development of ovarian follicles caused by high testosterone concentration, MOLECULAR MEDICINE REPORTS, 2017, 第 7 作者
（38） Wt1 directs the lineage specification of sertoli and granulosa cells by repressing Sf1 expression, DEVELOPMENT, 2017, 第 13 作者  通讯作者
（39） High Autophagic Flux Guards ESC Identity Through Coordinating Autophagy Machinery Gene Program by FOXO1, CELL DEATH AND DIFFERENTIATION, 2017, 第 10 作者
（40） Mutations in MSH5 in Primary Ovarian Insufficiency, HUMAN MOLECULAR GENETICS, 2017, 第 10 作者  通讯作者
（41） Transcription Factor RFX2 Is a Key Regulator of Mouse Spermiogenesis, SCIENTIFIC REPORTS, 2016, 第 14 作者
（42） STMN1 Promotes Progesterone Production Via StAR Up-regulation in Mouse Granulosa Cells, SCIENTIFIC REPORTS, 2016, 第 14 作者
（43） Adiponectin-Derived Active Peptide ADP355 Exerts Anti-Inflammatory and Anti-Fibrotic Activities in Thioacetamide-Induced Liver Injury, SCIENTIFIC REPORTS, 2016, 第 12 作者
（44） H2B Ubiquitination Regulates Meiotic Recombination by Promoting Chromatin Relaxation, NUCLEIC ACIDS RESEARCH, 2016, 第 13 作者
（45） Plumbagin protects liver against fulminant hepatic failure and chronic liver fibrosis via inhibiting inflammation and collagen production, ONCOTARGET, 2016, 第 17 作者
（46） Mesenchymal Stem Cells and Their Secreted Molecules Predominantly Ameliorate Fulminant Hepatic Failure and Chronic Liver Fibrosis in Mice Respectively, JOURNAL OF TRANSLATIONAL MEDICINE, 2016, 第 15 作者  通讯作者
（47） Mea6 Controls VLDL Transport Through the Coordinated Regulation of COPII Assembly, CELL RESEARCH, 2016, 第 13 作者
（48） Autophagy Is Required for Ectoplasmic Specialization Assembly in Sertoli Cells, AUTOPHAGY, 2016, 第 12 作者
（49） Mammalian Elongation Factor 4 Regulates Mitochondrial Translation Essential for Spermatogenesis, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2016, 第 11 作者
（50） Changes in the morphology and protein expression of germ cells and Sertoli cells in plateau pikas testes during non-breeding season, SCIENTIFIC REPORTS, 2016, 第 10 作者  通讯作者
（51） Histone Arginine Methylation by PRMT7 Controls Germinal Center Formation via Regulating Bcl6 Transcription, JOURNAL OF IMMUNOLOGY, 2015, 第 6 作者
（52） High levels of testosterone inhibit ovarian follicle development by repressing the FSH signaling pathway, JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES, 2015, 第 8 作者  通讯作者
（53） High Levels of Testosterone Inhibit Ovarian Follicle Development by Repressing the FSH Signaling Pathway, High Levels of Testosterone Inhibit Ovarian Follicle Development by Repressing the FSH Signaling Pathway, 华中科技大学学报：医学英德文版, 2015, 第 8 作者
（54） Reprogramming of Sertoli Cells to Fetal-Like Leydig Cells by Wt1 Ablation, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 第 11 作者  通讯作者
（55） Prmt5 Is Required for Germ Cell Survival During Spermatogenesis in Mice, SCIENTIFIC REPORTS, 2015, 第 11 作者  通讯作者
（56） Novel WT1 Missense Mutations in Han Chinese Women with Premature Ovarian Failure, SCIENTIFIC REPORTS, 2015, 第 4 作者
（57） Protein Arginine Methyltransferase 5 (Prmt5) Is Required for Germ Cell Survival During Mouse Embryonic Development, BIOLOGY OF REPRODUCTION, 2015, 第 10 作者  通讯作者
（58） CSB-PGBD3 Mutations Cause Premature Ovarian Failure, PLOS GENETICS, 2015, 第 8 作者
（59） Impact of Immune Response on the Use of iPSCs in Disease Modeling, CURRENT STEM CELL RESEARCH & THERAPY, 2015, 第 3 作者
（60） Equatorin Is Not Essential for Acrosome Biogenesis but Is Required for the Acrosome Reaction, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 第 12 作者
（61） Generation of Male Germ Cells from Mouse Induced Pluripotent Stem Cells in Vitro, STEM CELL RESEARCH, 2014, 第 7 作者
（62） Wt1 Dictates the Fate of Fetal and Adult Leydig Cells During Development in the Mouse Testis, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2014, 第 5 作者
（63） Wt1 Is Involved in Leydig Cell Steroid Hormone Biosynthesis by Regulating Paracrine Factor Expression in Mice(1), BIOLOGY OF REPRODUCTION, 2014, 第 9 作者  通讯作者
（64） Wt1 Functions in Ovarian Follicle Development by Regulating Granulosa Cell Differentiation, HUMAN MOLECULAR GENETICS, 2014, 第 1 作者  通讯作者
（65） Atg7 Is Required for Acrosome Biogenesis During Spermatogenesis in Mice, CELL RESEARCH, 2014, 第 12 作者
（66） Wt1 Deficiency Causes Undifferentiated Spermatogonia Accumulation and Meiotic Progression Disruption in Neonatal Mice, REPRODUCTION, 2014, 第 10 作者
（67） Disruption of Genital Ridge Development Causes Aberrant Primordial Germ Cell Proliferation But Does Not Affect Their Directional Migration, BMC BIOLOGY, 2013, 第 4 作者  通讯作者
（68） The Wilms Tumor Gene,Wt1,Maintains Testicular Cord Integrity by Regulating the Expression of Col4a1 and Col4a2, BIOLOGY OF REPRODUCTION, 2013, 第 8 作者  通讯作者
（69） Expression of Inhibin-Alpha Is Regulated Synergistically by Wilms' Tumor Gene 1 (Wt1) and Steroidogenic Factor-1 (Sf1) in Sertoli Cells, PLOS ONE, 2013, 第 9 作者  通讯作者
（70） The Wilms Tumor Gene,Wt1,Is Critical for Mouse Spermatogenesis via Regulation of Sertoli Cell Polarity and Is Associated with Non-Obstructive Azoospermia in Humans, PLOS GENETICS, 2013, 第 24 作者
（71） Sf1， Wnt和cAMP信号通路协同参与抑制素a基因转录的调控, 中国科学. 生命科学, 2013, 第 7 作者
（72） Fragile X premutation RNA is sufficient to cause primary ovarian insufficiency in mice, HUMAN MOLECULAR GENETICS, 2012, 第 6 作者
（73） Notch Signaling Is Involved in Ovarian Follicle Development by Regulating Granulosa Cell Proliferation, ENDOCRINOLOGY, 2011, 第 8 作者
（74） Wt1 Ablation and Igf2-Up-regulation in Mice Result in Wilms Tumors with Activated pERK1/2., JCI, 2011, 第 1 作者
（75） Fate determination of fetal Leydig cells, Fate determination of fetal Leydig cells, 生物学前沿:英文版, 2011, 第 3 作者
（76） Acrosome formation-associated factor is involved in fertilization, FERTILITY AND STERILITY, 2010, 第 11 作者
（77） Immunization with a DNA vaccine of testis-specific sodium-hydrogen exchanger by oral feeding or nasal instillation reduces fertility in female mice, FERTILITY AND STERILITY, 2010, 第 6 作者
（78） Testosterone Induces Redistribution of Forkhead Box-3a and Down-Regulation of Growth and Differentiation Factor 9 Messenger Ribonucleic Acid Expression at Early Stage of Mouse Folliculogenesis, ENDOCRINOLOGY, 2010, 第 11 作者
（79） Increased expression of heat shock protein 105 in rat uterus of early pregnancy and its significance in embryo implantation, REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 2009, 第 8 作者
（80） Effect of 43 degrees C treatment on expression of heat shock proteins 105, 70 and 60 in cultured monkey Sertoli cells, ASIAN JOURNAL OF ANDROLOGY, 2008, 第 6 作者
（81） Effect of 43��C treatment on expression of heat shock proteins 105, 70 and 60 in cultured monkey Sertoli cells, ASIAN JOURNAL OF ANDROLOGY, 2008, 第 7 作者
（82） Wt1 negatively regulates beta-catenin signaling during testis development, DEVELOPMENT, 2008, 第 2 作者
（83） Effect of heat stress on expression of junction-associated molecules and upstream factors androgen receptor and Wilms' tumor 1 in monkey sertoli cells, ENDOCRINOLOGY, 2008, 第 11 作者
（84） Wt1 is Required for Sox9 Expression and Normal Tubular Architecture in the Developing Testes., 2006, 第 1 作者
（85） MMP-2，-9，-14及其抑制剂TIMP-1，-2，-3在恒河猴周期黄体中的时空表达, 中国科学：C辑, 2005, 第 3 作者
（86） MMP-2，-9，-14及其抑制剂TIMP-1，-2，-3在恒河猴周期黄体中的时空表达, 中国科学：C辑, 2005, 第 3 作者
（87） MOUSE WT1 MISSENSE MUTATION RESULTS IN GLOMERULOSCLEROSIS CHARACTERISTIC OF HUMAN DENYS-DRASH SYNDROME., 2004, 第 1 作者
（88） 子宫内膜接受性与金属蛋白酶及其抑制因子表达之间的关系, 中国科学：C辑, 2002, 第 1 作者
（89） 金属蛋白酶—2（MMP—2）和金属蛋白酶抑制因子（TIMP—1，—3）mRNA在小鼠胎盘中的表达, Expression of MMP-2, TIMP-1, -3 mRNAs in mouse placenta, 动物学报, 2002, 第 1 作者
（90） 子宫内膜接受性与金属蛋白酶及其抑制因子表达之间的关系, 中国科学：C辑, 2002, 第 1 作者
（91） VEGF及其受体在早期胎盘发生过程中的表达, 发育与生殖生物学报：英文版, 2001, 第 2 作者
（92） 胎盘发生过程中的细胞凋亡, Apoptosis during placentation, 生理学报, 2001, 第 3 作者
（93） MMP—2，TIMP—1，—3在恒河猴妊娠早期着床点的表达, 发育与生殖生物学报：英文版, 2001, 第 1 作者
（94） TGF—β在小鼠胎盘中的表达, Expression of TGF-�� in the Mouse Placenta, 动物学研究, 2001, 第 4 作者
（95） 子宫内膜接受性与金属蛋白酶及其抑制因子表达之间关系的研究, 发育与生殖生物学报：英文版, 2001, 第 1 作者

   

（ 1 ） 原始生殖细胞发育调控, 负责人, 国家任务, 2018-07--2022-12
（ 2 ） 配子发生相关疾病, 负责人, 国家任务, 2016-01--2020-12
（ 3 ） 组蛋白甲基转移酶Prmt7在雄性生殖细胞发育过程中的功能研究, 负责人, 国家任务, 2015-01--2018-12
（ 4 ） 原始生殖细胞特化和定向迁移, 负责人, 国家任务, 2013-03--2017-12
（ 5 ） 精子遗传信息稳定遗传的分子机制, 参与, 国家任务, 2011-01--2015-12

（1）Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1ablation   zhanglianjun   2015-05-31
（2）Wt1 directs the supporting cells lineage specification and maintenance during gonad development   chenmin zhanglianjun   2014-10-26