基本信息
佟卉春  女  硕导  中国科学院微生物研究所
电子邮件: tonghuichun@im.ac.cn
通信地址: 北京市朝阳区北辰西路1号院3号
邮政编码: 100101

招生信息

   
招生专业
071005-微生物学
招生方向
链球菌抗氧胁迫及致病的分子机制

教育背景

2005-03--2005-07   School of Dentistry, University of California, Los angeles   访问学习
2000-08--2003-07   北京大学医学部   博士
1995-08--1998-07   中国医科大学   硕士
1988-08--1993-07   中国医科大学   本科

工作经历

   
工作简历
2009-03~2010-03,School of Dentistry, University of Florida, 访问学者
2007-05~现在, 中国科学院微生物研究所, 副研究员
2005-03~2005-07,School of Dentistry, University of California, Los angeles, 访问学习
2003-08~2007-05,中国科学院微生物研究所, 助理研究员
2000-08~2003-07,北京大学医学部, 博士
1995-08~1998-07,中国医科大学, 硕士
1988-08~1993-07,中国医科大学, 本科

教授课程

微生物学实验技术

出版信息

   
发表论文
(1) A 3' UTR-derived small RNA represses pneumolysin synthesis and facilitates pneumococcal brain invasion, COMMUNICATIONS BIOLOGY, 2024, 第 7 作者  通讯作者
(2) Pn-AqpC-Mediated Fermentation Pattern Coordination with the Two-Component System 07 Regulates Host N-Glycan Degradation of Streptococcus pneumoniae, MICROBIOLOGY SPECTRUM, 2022, 第 8 作者  通讯作者
(3) A Novel Aquaporin Subfamily Imports Oxygen and Contributes to Pneumococcal Virulence by Controlling the Production and Release of Virulence Factors, MBIO, 2021, 第 2 作者  通讯作者
(4) RNase Z Oxidative Degradation Impedes tRNA Maturation and is Involved in Streptococcal Translation Regulation in Response to Oxidative Stress, MICROBIOLOGY SPECTRUM, 2021, 第 2 作者  通讯作者
(5) Redox-Regulated Adaptation of Streptococcus oligofermentans to Hydrogen Peroxide Stress, MSYSTEMS, 2020, 第 1 作者  通讯作者
(6) Redox-Regulated Adaptation of Streptococcus oligofermentans to Hydrogen Peroxide Stress, MSYSTEMS, 2020, 第 1 作者
(7) A Streptococcus aquaporin acts as peroxiporin for efflux of cellular hydrogen peroxide and alleviation of oxidative stress, JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 第 1 作者  通讯作者
(8) Prokaryotic Aquaporins, CELLS, 2019, 第 1 作者  通讯作者
(9) The carbon catabolite repressor CcpA mediates optimal competence development in Streptococcus oligofermentans through post-transcriptional regulation, MOLECULAR MICROBIOLOGY, 2019, 第 7 作者  通讯作者
(10) Molecular Insights into Hydrogen Peroxide-sensing Mechanism of the Metalloregulator MntR in Controlling Bacterial Resistance to Oxidative Stresses, JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 第 5 作者  通讯作者
(11) Streptococcus oligofermentans Inhibits Streptococcus mutans in Biofilms at Both Neutral pH and Cariogenic Conditions, PLOS ONE, 2015, 第 3 作者
(12) PerR-Regulated Manganese Ion Uptake Contributes to Oxidative Stress Defense in an Oral Streptococcus, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2014, 第 2 作者  通讯作者
(13) Complete Genome Sequence of an Oral Commensal, Streptococcus oligofermentans Strain AS 1.3089, GENOME ANNOUNCEMENTS, 2013, 第 1 作者
(14) Function of the Pyruvate Oxidase-Lactate Oxidase Cascade in Interspecies Competition between Streptococcus oligofermentans and Streptococcus mutans, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2012, 第 2 作者  通讯作者
(15) Role of Operon aao So -mutT in Antioxidant Defense in Streptococcus oligofermentans, PLOS ONE, 2012, 第 3 作者
(16) Role of Operon aao-mutT in Antioxidant Defense in Streptococcus oligofermentans, PLoS One, 2012, 第 1 作者  通讯作者
(17) CcpA-Dependent Carbohydrate Catabolite Repression Regulates Galactose Metabolism in Streptococcus oligofermentans, JOURNAL OF BACTERIOLOGY, 2012, 第 2 作者
(18) The EIIABman PTS permease regulates carbohydrate catabolite repression in Streptococcus gordonii, Appl Environ Microbiol, 2011, 第 1 作者
(19) The EIIAB(Man) Phosphotransferase System Permease Regulates Carbohydrate Catabolite Repression in Streptococcus gordonii, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2011, 第 1 作者
(20) A Preliminary Study of Biological Characteristics of Streptococcus oligofermentans in Oral Microecology, CARIES RESEARCH, 2010, 
(21) Dpr蛋白在寡发酵链球菌抗过氧化氢中的作用, Role of Dpr in hydrogen peroxide tolerance of Streptococcus oligofermentans, 微生物学报, 2009, 第 2 作者
(22) SO-LAAO, a Novel l -Amino Acid Oxidase That Enables Streptococcus oligofermentans To Outcompete Streptococcus mutans by Generating H 2 O 2 from Peptone ��� ���, JOURNAL OF BACTERIOLOGY, 2008, 第 1 作者
(23) SO-LAAO, a novel L-amino acid oxidase that enables Streptococcus oligofermentans to outcompete Streptococcus mutans by generation H2O2 from peptone, J Bacteriol, 2008, 第 1 作者
(24) 寡发酵链球菌分子标识鉴定方法的建立, Development of an identification method for Streptococcus oligofermentans: a new species of oral streptococci with molecular markers, 中华口腔医学杂志, 2007, 第 2 作者
(25) Streptococcus oligofermentans inhibits streptococcus mutans through conversion of lactic acid into inhibitory h2o2: a possible counteroffensive strategy for interspecies competition, MOLECULAR MICROBIOLOGY, 2007, 第 1 作者
(26) 一株口腔链球菌新种-寡发酵链球菌产过氧化氢特性的研究, Characterization of hydrogen peroxide production by a novel oral streptococci,S. oligofermentans isolated from human oral cavity, 微生物学报, 2006, 第 2 作者
(27) Pediococcus ethanolidurans sp nov., isolated from the walls of a distilled-spirit-fermenting cellar, INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, 2006, 第 3 作者
(28) Establishing a genetic system for ecological studies of Streptococcus oligofermentans, FEMS MICROBIOLOGY LETTERS, 2006, 第 1 作者
(29) Molecular Insights into Hydrogen Peroxide-sensing Mechanism of the Metalloregulator MntR in Controlling Bacterial Resistance to Oxidative Stresses *, THE JOURNAL OF BIOLOGICAL CHEMISTRY, 第 5 作者

科研活动

   
科研项目
( 1 ) 水圈碳氮硫元素循环的功能微生物及其代谢途径和机制, 参与, 国家任务, 2023-01--2024-12
( 2 ) 肺炎链球菌水通道蛋白的生理功能及其介导毒力的分子机制, 负责人, 国家任务, 2019-01--2023-12
( 3 ) 肺炎链球菌水通道蛋白的生理功能及其介导毒力的分子机制, 负责人, 国家任务, 2019-01--2023-12
( 4 ) 副乾酪乳桿菌V0151生理、生化特性及动物毒性的影响, 参与, 境内委托项目, 2014-02--2014-08
( 5 ) 寡发酵链球菌抗氧胁迫的分子机制, 负责人, 国家任务, 2014-01--2017-12
参与会议
(1)链球菌抗氧胁迫的分子机制   2019年全国微生物学年会   2019-10-12