基本信息
李亚平  男  博导  中国科学院上海药物研究所
电子邮件: ypli@simm.ac.cn
通信地址: 上海市浦东张江海科路501号
邮政编码: 201203

招生信息

   
招生专业
100702-药剂学
招生方向
纳米药物与靶向制剂

教育背景

2001-09--2002-12   德国慕尼黑大学药物研究中心   博士后
1998-09--2001-06   复旦大学   博士学位
1993-09--1996-06   沈阳药科大学   硕士学位

工作经历

   
工作简历
2001-09~2002-12,德国慕尼黑大学药物研究中心, 博士后
1998-09~2001-06,复旦大学, 博士学位
1996-07~现在, 中国科学院上海药物研究所, 助理研究员/副研究员/研究员/课题组长/主任
1993-09~1996-06,沈阳药科大学, 硕士学位
1987-01~1993-08,湖北安陆制药厂, 历任技术员/助理工程师/主任/科长
社会兼职
2022-12-01-今,中国抗癌协会, 理事
2022-12-01-今,中国抗癌协会纳米肿瘤学专业委员会, 主任委员
2017-05-01-今,中国药学会, 理事
2015-04-01-今,中国药学会纳米药物专业委员会, 副主任委员
2013-04-01-今,中国医药生物技术协会基因治疗分会, 常委
2011-08-01-今,中国毒理学会纳米毒理学专业委员会, 常委
2011-06-01-今,上海市药学会药剂专业委员会, 副主任委员
2011-05-01-今,上海市药学会, 理事
2010-12-01-今,纳米生物医药产业技术创新战略联盟, 理事
2010-10-01-今,国际控释协会(CRS)中国分会,
2006-01-01-今,中国药学会药剂专业委员会, 委员
2004-07-01-今,Controlled Release Society,

教授课程

高等药剂学
纳米生物效应---- "杰青学者论坛"系列讲座

专利与奖励

   
奖励信息
(1) 上海市科技精英, 省级, 2022
(2) 吴阶平医药创新奖, 部委级, 2022
(3) 提高难溶性药物体内递送效率的制剂关键技术及应用, 一等奖, 省级, 2022
(4) 新型纳米载药系统克服肿瘤化疗耐药的应用基础研究, 二等奖, 国家级, 2020
(5) 提高难溶性药物疗效与候选药物成药性的载药系统研究, 一等奖, 其他, 2020
(6) 吴阶平-保罗·杨森医学药学奖, 其他, 2018
(7) 中国药学会-以岭生物医药创新奖, 其他, 2018
(8) 国家万人计划科技创新领军人才, 部委级, 2017
(9) 中国药学会科学技术奖一等奖, 一等奖, 部委级, 2015
(10) 国家有突出贡献中青年专家, 部委级, 2015
(11) 国家百千万人才工程, 部委级, 2015
(12) 中科院优秀研究生指导导师, 院级, 2014
(13) 上海药学科技奖一等奖, 一等奖, 省级, 2013
(14) 药明康德生命化学奖学者奖, 其他, 2013
(15) 中科院优秀研究生指导导师, 院级, 2012
(16) 上海市优秀学术带头人, 省级, 2011
(17) 中科院优秀研究生指导导师, 院级, 2011
(18) 中科院优秀研究生指导导师, 院级, 2010
(19) 上海市领军人才, 省级, 2010
(20) 中国科学院朱李月华优秀教师奖, , 院级, 2010
(21) 上海药学科技奖, 一等奖, 省级, 2009
(22) 中国药学科学技术奖, 三等奖, 部委级, 2008
专利成果
( 1 ) 一种用于包载蛋白药物的聚合物,由其制成的氧化还原响应性纳米粒及其应用, 2022, 第 1 作者, 专利号: CN202210008967.9

( 2 ) 口服生物粘附药物组合物及其用途, 2021, 第 1 作者, 专利号: CN202111661637.1

( 3 ) 一种基于巨噬细胞的活细胞载药系统、其制备方法和应用, 2021, 第 1 作者, 专利号: CN110507826B

( 4 ) 两亲性聚氟化物,其制备方法及用途, 2021, 第 3 作者, 专利号: CN111484622B

( 5 ) 奥沙利铂偶联前药、其制备方法及用途, 2021, 第 2 作者, 专利号: CN110872324B

( 6 ) 类磷脂奥沙利铂前体,其制备方法及用途, 2021, 第 2 作者, 专利号: CN110302390B

( 7 ) 一种脂质体,其制备方法及应用, 2021, 第 1 作者, 专利号: CN202110348853.4

( 8 ) 包含肿瘤新生抗原纳米制剂和树突状细胞疫苗的试剂盒及其用途, 2021, 第 2 作者, 专利号: CN202110208508.0

( 9 ) 硫酸乙酰肝素-骨化三醇偶联物,包含其的乙酰肝素酶响应性纳米粒,其制备方法及用途, 2021, 第 1 作者, 专利号: CN202110171207.5

( 10 ) 肿瘤免疫脂质体,其制备方法和用途, 2020, 第 2 作者, 专利号: CN111840228A

( 11 ) 普罗布考单琥珀酸酯的多晶型, 2020, 第 2 作者, 专利号: CN111434647A

( 12 ) 酸响应聚阳离子胶束纳米粒、其制备方法及用途, 2019, 第 2 作者, 专利号: CN110368364A

( 13 ) 一种水凝胶肿瘤疫苗的制备方法以及由其制备的水凝胶肿瘤疫苗和其用途, 2019, 第 2 作者, 专利号: CN110269931A

( 14 ) 奥沙利铂偶联前药、其制备方法及用途(PCT), 2019, 第 2 作者, 专利号: PCT/CN2019/101933

出版信息

   
发表论文
(1) Macrophage membrane-coated nano-gemcitabine promotes lymphocyte infiltration and synergizes antiPD-L1 to restore the tumoricidal function., Acs Nano, 2023, 通讯作者
(2) Bioinspired nanovehicle of furoxans-oxaliplatin improves tumoral distribution for chemo-radiotherapy, JOURNAL OF CONTROLLED RELEASE, 2023, 通讯作者
(3) Dual-responsive nanoparticles loading bevacizumab and gefitinib for molecular targeted therapy against non-small cell lung cancer, ACTA PHARMACOLOGICA SINICA, 2023, 通讯作者
(4) Promote intratumoral drug release and penetration to counteract docetaxel-induced metastasis by photosensitizer-modified red blood cell membranes-coated nanoparticle., Advanced Functional Materials, 2023, 通讯作者
(5) Nanomedicine Strategies to Circumvent Intratumor Extracellular Matrix Barriers for Cancer Therapy, ADVANCED HEALTHCARE MATERIALS, 2022, 第 7 作者
(6) Recent advances in developing active targeting and multi-functional drug delivery systems via bioorthogonal chemistry, Signal Transduction and Targeted Therapy, 2022, 通讯作者
(7) Poly(maleic anhydride-alt-1-octadecene)-based bioadhesive nanovehicles improve oral bioavailability of poor water-soluble gefitinib, DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2022, 通讯作者
(8) Anti-hypoxia nanosized drug delivery systems improving cancer therapy, NANO TODAY, 2022, 通讯作者
(9) Blocking Cholesterol Metabolism with Tumor-Penetrable Nanovesicles to Improve Photodynamic Cancer Immunotherapy, SMALL METHODS, 2022, 通讯作者
(10) Lenvatinib-and vadimezan-loaded synthetic high-density lipoprotein for combinational immunochemotherapy of metastatic triple-negative breast cancer, Lenvatinib- and vadimezan-loaded synthetic high-density lipoprotein for combinational immunochemotherapy of metastatic triple-negative breast cancer, ACTA PHARMACEUTICA SINICA B, 2022, 通讯作者
(11) Current approaches of nanomedicines in the market and various stage of clinical translation, Current approaches of nanomedicines in the market and various stage of clinical translation, ACTA PHARMACEUTICA SINICA B, 2022, 第 5 作者
(12) Strategies of engineering nanomedicines for tumor retention, JOURNAL OF CONTROLLED RELEASE, 2022, 通讯作者
(13) Walking Dead Tumor Cells for Targeted Drug Delivery Against Lung Metastasis of Triple-Negative Breast Cancer, ADVANCED MATERIALS, 2022, 通讯作者
(14) Amplifying antitumor T cell immunity with versatile drug delivery systems for personalized cancer immunotherapy, MEDICINE IN DRUG DISCOVERY, 2022, 第 2 作者
(15) ROS-Responsive Nanocomplex of aPD-L1 and Cabazitaxel Improves Intratumor Delivery and Potentiates Radiation-Mediated Antitumor Immunity, NANO LETTERS, 2022, 通讯作者
(16) Bioinspired lipoproteins of furoxans-oxaliplatin remodels physical barriers in tumor to potentiate T-cell infiltration., Advanced Materials, 2022, 通讯作者
(17) Improving oral bioavailability of water-insoluble idebenone with bioadhesive liposomes, JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2022, 通讯作者
(18) Light-controllable charge-reversal nanoparticles with polyinosinic-polycytidylic acid for enhancing immunotherapy of triple negative breast cancer, Light-controllable charge-reversal nanoparticles with polyinosinic-polycytidylic acid for enhancing immunotherapy of triple negative breast cancer, ACTA PHARMACEUTICA SINICA B, 2022, 通讯作者
(19) A bispecific nanomodulator to potentiate photothermal cancer immunotherapy, NANO TODAY, 2022, 通讯作者
(20) T lymphocyte membrane-decorated epigenetic nanoinducer of interferons for cancer immunotherapy, NATURE NANOTECHNOLOGY, 2021, 通讯作者
(21) Nanovaccine-Mediated Cell Selective Delivery of Neoantigens Potentiating Adoptive Dendritic Cell Transfer for Personalized Immunization, ADVANCED FUNCTIONAL MATERIALS, 2021, 通讯作者
(22) Gut Microbiota: Influence on Carcinogenesis and Modulation Strategies by Drug Delivery Systems to Improve Cancer Therapy, ADVANCED SCIENCE, 2021, 通讯作者
(23) High-density lipoprotein modulates tumor-associated macrophage for chemoimmunotherapy of hepatocellular carcinoma, NANO TODAY, 2021, 通讯作者
(24) Oxygen-Delivering Polyfluorocarbon Nanovehicles Improve Tumor Oxygenation and Potentiate Photodynamic-Mediated Antitumor Immunity, ACS NANO, 2021, 第 6 作者
(25) M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors, JOURNAL OF NANOBIOTECHNOLOGY, 2021, 通讯作者
(26) Engineering Nanoscale Artificial Antigen-Presenting Cells by Metabolic Dendritic Cell Labeling to Potentiate Cancer Immunotherapy, NANO LETTERS, 2021, 通讯作者
(27) Nano drug delivery systems improve metastatic breast cancer therapy, Nano drug delivery systems improve metastatic breast cancer therapy, Medical Review, 2021, 通讯作者
(28) Recent Progress in the Design and Application of Supramolecular Peptide Hydrogels in Cancer Therapy, ADVANCED HEALTHCARE MATERIALS, 2021, 通讯作者
(29) Ternary Regulation of Tumor Microenvironment by Heparanase-Sensitive Micelle-Loaded Monocytes Improves Chemo-Immunotherapy of Metastatic Breast Cancer, ADVANCED FUNCTIONAL MATERIALS, 2021, 通讯作者
(30) Erythrocyte-mediated systemic immunotherapy, NATURE BIOMEDICAL ENGINEERING, 2021, 第 2 作者
(31) Tumor Cells-Selective Bionic Nanodevice Exploiting Heparanase Combats Metastatic Breast Cancer, ADVANCED FUNCTIONAL MATERIALS, 2018, 通讯作者
(32) Light-Activated Core-Shell Nanoparticles for Spatiotemporally Specific Treatment of Metastatic Triple-Negative Breast Cancer, ACS NANO, 2018, 通讯作者
(33) A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors, NATURE COMMUNICATIONS, 2018, 通讯作者
(34) Inflammatory Monocytes Loading Protease-Sensitive Nanoparticles Enable Lung Metastasis Targeting and Intelligent Drug Release for Anti-Metastasis Therapy., NANO LETTERS, 2017, 通讯作者
(35) Tumoral acidity-triggered ligand presentation nanoparticles combating the sequential drug delivery barriers for cancer therapy, Nano Letters, 2017, 通讯作者
(36) Theranostic Prodrug Vesicles for Reactive Oxygen Species-Triggered Ultrafast Drug Release and Local-Regional Therapy of Metastatic Triple-Negative Breast Cancer, ADVANCED FUNCTIONAL MATERIALS, 2017, 通讯作者
(37) Programmed Multiresponsive Vesicles for Enhanced Tumor Penetration and Combination Therapy of Triple-Negative Breast Cancer, ADVANCED FUNCTIONAL MATERIALS, 2017, 通讯作者
(38) Albumin Biomimetic Nanocorona Improves Tumor Targeting and Penetration for Synergistic Therapy of Metastatic Breast Cancer, ADVANCED FUNCTIONAL MATERIALS, 2017, 通讯作者
(39) Cancer Cell Membrane-Coated Gold Nanocages with Hyperthermia-Triggered Drug Release and Homotypic Target Inhibit Growth and Metastasis of Breast Cancer, ADVANCED FUNCTIONAL MATERIALS, 2017, 通讯作者
(40) Ly6C(hi) Monocytes Delivering pH-Sensitive Micelle Loading Paclitaxel Improve Targeting Therapy of Metastatic Breast Cancer, ADVANCED FUNCTIONAL MATERIALS, 2017, 通讯作者
(41) Large Pore-Sized Hollow Mesoporous Organosilica for Redox-Responsive Gene Delivery and Synergistic Cancer Chemotherapy, ADVANCED MATERIALS, 2016, 通讯作者
(42) Cancer-Cell-Biomimetic Nanoparticles for Targeted Therapy of Homotypic Tumors, ADVANCED MATERIALS, 2016, 通讯作者
(43) Intracellularly acid-switchable multifunctional micelles for combinational photo/chemotherapy of drug resistant tumor., ACS Nano, 2016, 通讯作者
(44) Versatile Prodrug Nanoparticles for Acid-Triggered Precise Imaging and Organelle-Specific Combination Cancer Therapy, ADVANCED FUNCTIONAL MATERIALS, 2016, 通讯作者
(45) Liposome coated with isolated macrophage membrane can target lung metastasis of breast cancer, ACS Nano, 2016, 通讯作者
(46) Treatment of Malignant Brain Tumor by Tumor-Triggered Programmed Wormlike Micelles with Precise Targeting and Deep Penetration, ADVANCED FUNCTIONAL MATERIALS, 2016, 通讯作者
(47) Long circulation RBC-mimetic nanoparticles with peptide-enhanced tumor penetration for simultaneously inhibiting growth and lung metastasis of breast cancer., Adv Funct Mater, 2016, 通讯作者
(48) Bioinspired Nanoparticles with NIR-Controlled Drug Release for Synergetic Chemophotothermal Therapy of Metastatic Breast Cancer, ADVANCED FUNCTIONAL MATERIALS, 2016, 通讯作者
(49) Tumor-Microenvironment-Adaptive Nanoparticles Codeliver Paclitaxel and siRNA to Inhibit Growth and Lung Metastasis of Breast Cancer, ADVANCED FUNCTIONAL MATERIALS, 2016, 通讯作者
(50) Acid-activatable versatile micelleplexes for pd-l1 blockade enhanced cancer photodynamic immunotherapy, NANO LETTERS, 2016, 通讯作者
(51) Shrapnel nanoparticles loading docetaxel inhibit metastasis and growth of breast cancer, BIOMATERIALS, 2015, 第 9 作者
(52) Large pore-sized ultrasmall mesoporous organosilica nanoparticles: micelle/precursor co-templating assembly and nuclear-targeted gene delivery., Adv Mater 27(2015)215-22., 2015, 通讯作者
(53) Inhibition of metastasis and growth of breast cancer by pH-sensitive poly (β-amino ester) nanoparticles co-delivering two siRNA and paclitaxel, BIOMATERIALS, 2015, 第 13 作者
(54) pH and near-Infrared light-responsive micelles with hyperthermia-triggered tumor penetration and cytoplasm drug release reverse doxorubicin resistance in breast cancer., Adv Funct Mater 25(2015)2489-500, 2015, 通讯作者
(55) Tumor-Penetrating Nanotherapeutics Loading a Near-Infrared Probe Inhibit Growth and Metastasis of Breast Cancer, ADVANCED FUNCTIONAL MATERIALS, 2015, 第 9 作者
(56) The use of lipid-coated nanodiamond to improve bioavailability and efficacy of sorafenib in resisting metastasis of gastric cancer, BIOMATERIALS, 2014, 通讯作者
(57) Hollow mesoporous rganosilica nanoparticles: a generic intelligent framework-hybridization approach for biomedicine., J Am Chem Soc 136(2014) 16326-34., 2014, 通讯作者
(58) Colloidal RBCs-shaped, hydrophilic and hollow mesoporous carbon nanocapsules for highly efficient biomedical engineering., Adv Mater 26(2014)4294-301, 2014, 通讯作者
(59) Co-delivery of doxorubicin and RNA using pH-sensitive poly (β-amino ester) nanoparticles for reversal of multidrug resistance of breast cancer, BIOMATERIALS, 2014, 第 10 作者
(60) The inhibition of metastasis and growth of breast cancer by blocking the NF-κB signaling pathway using bioreducible PEI-based/p65 shRNA complex nanoparticles, BIOMATERIALS, 2013, 第 9 作者
(61) Reversal of multidrug resistant by stimuli-responsive drug delivery systems for therapy of tumor., Adv Drug Deliv Rev 65(2013):1699-1715, 2013, 通讯作者
(62) Colloidal HPMO NPs:silica-etching chemistry tailoring, topological transformation and nano-biomedical applications., Adv Mater 25(2013):3100-5, 2013, 通讯作者
(63) Nanodiamonds-mediated doxorubicin nuclear delivery to inhibit lung metastasis of breast cancer, BIOMATERIALS, 2013, 通讯作者
(64) A self-assembled nanocarrier loading teniposide improves the oral delivery and drug concentration in tumor, JOURNAL OF CONTROLLED RELEASE, 2013, 通讯作者
(65) Smart pH-Sensitive and Temporal-Controlled Polymeric Micelles for Effective Combination Therapy of Doxorubicin and Disulfiram, ACS NANO, 2013, 通讯作者
(66) Engineering Inorganic Nanoemulsions/Nanoliposomes by Fluoride-Silica Chemistry for Efficient Delivery/Co-Delivery of Hydrophobic Agents, ADVANCED FUNCTIONAL MATERIALS, 2012, 第 5 作者
(67) Bioreducible poly (β-amino esters)/shRNA complex nanoparticles for efficient RNA delivery, JOURNAL OF CONTROLLED RELEASE, 2011, 第 5 作者
(68) Nanoemulsion improves the oral absorption of candesartan cilexetil in rats: Performance and mechanism., JOURNAL OF CONTROLLED RELEASE : OFFICIAL JOURNAL OF THE CONTROLLED RELEASE SOCIETY, 2011, 第 8 作者
(69) Downregulation of survivin expression and enhanced chemosensitivity of MCF-7 cells to adriamycin by PDMAE/survivin shRNA complex nanoparticles, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2011, 第 5 作者
(70) Linear Cationic Click Polymers/DNA Nanoparticles: In Vitro Structure-Activity Relationship and In Vivo Evaluation for Gene Delivery, BIOCONJUGATE CHEMISTRY, 2011, 通讯作者
(71) In vivo Biodistribution and Urinary Excretion of Mesoporous Silica Nanoparticles: Effects of Particle Size and PEGylation, SMALL, 2011, 通讯作者
(72) A self-assembled nano-delivery system enhancing the oral bioavailability of daidzein: in vitro characteristics and in vivo performance, Nanomedicine UK (2011, in press), 2011, 通讯作者
(73) Reversal of multidrug resistance by reduction-sensitive linear cationic click polymer/iMDR1-pDNA complex nanoparticles, BIOMATERIALS, 2011, 通讯作者
(74) Solid lipid nanoparticles reduce systemic toxicity of docetaxel: Performance and mechanism in animal, NANOTOXICOLOGY, 2011, 通讯作者
(75) Daidzein-phospholipid complex loaded lipid nanocarriers improved oral absorption: in vitro characteristics and in vivo behavior in rats, NANOSCALE, 2011, 通讯作者
(76) Galactosylated Poly(2-(2-aminoethyoxy)ethoxy)phosphazene/DNA Complex Nanoparticles: In Vitro and In Vivo Evaluation for Gene Delivery, BIOMACROMOLECULES, 2010, 通讯作者
(77) Urocanic Acid Improves Transfection Efficiency of Polyphosphazene with Primary Amino Groups for Gene Delivery, BIOCONJUGATE CHEMISTRY, 2010, 通讯作者
(78) Poly(epsilon-caprolactone)-Block-poly(ethyl Ethylene Phosphate) Micelles for Brain-Targeting Drug Delivery: In Vitro and In Vivo Valuation, PHARMACEUTICALRESEARCH, 2010, 通讯作者
(79) A Novel Linear Cationic Click Polymer for Gene Delivery: Synthesis, Biocompatibility and In Vitro Transfection, Biomacromolecules 11 (2010) 3102-3111, 2010, 通讯作者
(80) Effect of multifold charge groups and imidazole-4-carboxaldehyde on physicochemical characteristics and transfection of cationic polyphosphazenes/DNA complexes, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2010, 通讯作者
(81) The characteristics and performance of a multifunctional nanoassembly system for the co-delivery of docetaxel and iSur-pDNA in a mouse hepatocellular carcinoma model, BIOMATERIALS, 2010, 通讯作者
(82) Folate-PEG modified poly(2-(2-aminoethoxy)ethoxy)phosphazene/DNA nanoparticles for gene delivery: Synthesis, preparation and in vitro transfection efficiency, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2010, 通讯作者
(83) Prostaglandin E-1 encapsulated into lipid nanoparticles improves its anti-inflammatory effect with low side-effect, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2010, 通讯作者
(84) "Intelligent" nanoassembly for gene delivery: In vitro transfection and the possible mechanism, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2010, 通讯作者
(85) The characteristics and mechanism of simvastatin loaded lipid nanoparticles to increase oral bioavailability in rats, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2010, 通讯作者

科研活动

   
科研项目
( 1 ) 基于纳米技术的药物新剂型改善肿瘤治疗效果的应用基础研究, 负责人, 国家任务, 2010-01--2014-08
( 2 ) 基于纳米技术的抗癌药物新型递, 负责人, 国家任务, 2016-01--2021-12
( 3 ) 靶向治疗肿瘤的新型阳离子聚(β-氨基酯)/RNA 自组装纳米粒的研究, 负责人, 国家任务, 2013-01--2017-12
( 4 ) 纳米药物的产业化技术, 负责人, 中国科学院计划, 2013-07--2018-06
( 5 ) 基于红细胞膜的靶向纳米释药系统抗乳腺癌的肺转移研究, 负责人, 国家任务, 2017-01--2021-12
( 6 ) 生物大分子药物高效递释系统的药效与安全性, 负责人, 国家任务, 2017-01--2021-12
( 7 ) 基于红细胞膜的仿生纳米药物抗乳腺癌的肺转移, 负责人, 中国科学院计划, 2016-08--2020-12
( 8 ) 核酸药物的体内靶向递送关键技术, 负责人, 国家任务, 2022-11--2027-10
( 9 ) 靶向肿瘤的仿生纳米囊泡提高表观遗传抗癌疗效, 负责人, 国家任务, 2022-01--2026-12
( 10 ) 三元协同的酶敏感纳米载药系统改善肿瘤免疫检查点阻断治疗效果的研究, 负责人, 国家任务, 2020-01--2024-12
参与会议
(1)精准递送+智能释药一体化(SNP)递送RNA药物 抗乳腺癌的肺转移   2022中国药学大会纳米药物创新与产业化论坛   李亚平   2022-11-29
(2)耐药克星与智能化递药   2022中国肿瘤学大会   李亚平   2022-11-19
(3)精准递送与智能释药一体化克服肿瘤耐药   2021年中国药物制剂大会   李亚平   2021-12-12
(4)Integration of Precise Delivery and Intelligent Drug Release as an Effective Strategy to Treat Metastatic Cancers   ChinaNanomedicine 2021   李亚平   2021-11-14
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