基本信息
李亚平  男  博导  中国科学院上海药物研究所
电子邮件: ypli@mail.shcnc.ac.cn
通信地址: 上海市浦东张江海科路501号
邮政编码: 201203

招生信息

   
招生专业
100702-药剂学
招生方向
纳米药物与靶向制剂

教育背景

2001-09--2002-12   德国慕尼黑大学药物研究中心   博士后
1998-09--2001-06   复旦大学   博士学位
1993-09--1996-06   沈阳药科大学   硕士学位

工作经历

   
工作简历
2001-09~2002-12,德国慕尼黑大学药物研究中心, 博士后
1998-09~2001-06,复旦大学, 博士学位
1996-07~现在, 中国科学院上海药物研究所, 助理研究员/副研究员/研究员/课题组长/主任
1993-09~1996-06,沈阳药科大学, 硕士学位
1987-01~1993-08,湖北安陆制药厂, 历任技术员/助理工程师/主任/科长
社会兼职
2017-05-01-今,中国药学会, 理事
2015-04-01-今,中国药学会纳米药物专业委员会, 副主任委员
2013-04-01-今,中国医药生物技术协会基因治疗分会, 常委
2012-11-01-今,国抗癌协会纳米肿瘤学专业委员会, 副主任委员
2012-11-01-今,中国抗癌协会纳米肿瘤学专业委员会, 副主任委员
2011-08-01-今,中国毒理学会纳米毒理学专业委员会, 常委
2011-06-01-今,上海市药学会药剂专业委员会, 副主任委员
2011-05-01-今,上海市药学会, 理事
2010-12-01-今,纳米生物医药产业技术创新战略联盟, 理事
2010-10-01-今,国际控释协会(CRS)中国分会,
2006-01-01-今,中国药学会药剂专业委员会, 委员
2004-07-01-今,Controlled Release Society,

教授课程

高等药剂学
纳米生物效应---- "杰青学者论坛"系列讲座

专利与奖励

   
奖励信息
(1) 国家万人计划科技创新领军人才, 部委级, 2017
(2) 国家百千万人才工程, 部委级, 2015
(3) 国家有突出贡献中青年专家, 部委级, 2015
(4) 中国药学会科学技术奖一等奖, 一等奖, 部委级, 2015
(5) 中科院优秀研究生指导导师, 院级, 2014
(6) 药明康德生命化学奖学者奖, 其他, 2013
(7) 上海药学科技奖一等奖, 一等奖, 省级, 2013
(8) 中科院优秀研究生指导导师, 院级, 2012
(9) 上海市优秀学术带头人, 省级, 2011
(10) 中科院优秀研究生指导导师, 院级, 2011
(11) 上海市领军人才, 省级, 2010
(12) 中国科学院朱李月华优秀教师奖, , 院级, 2010
(13) 中科院优秀研究生指导导师, 院级, 2010
(14) 上海药学科技奖, 一等奖, 省级, 2009
(15) 中国药学科学技术奖, 三等奖, 部委级, 2008
专利成果
( 1 ) 聚乙二醇化奥沙利铂前药及其制备方法和用途, 2016, 第 2 作者, 专利号: 201610541282.5

( 2 ) 两亲性奥沙利铂前体,其制备方法及用途, 2016, 第 2 作者, 专利号: 201610514832.4

( 3 ) 一种用于提高普罗布考口服吸收的多孔复合载药组合物及其制备方法, 2016, 第 1 作者, 专利号: ZL 201210065776.2

( 4 ) 光控温敏脂质体及其制备方法和用途, 2016, 第 2 作者, 专利号: 201610128545.X

( 5 ) 一种卡巴他赛磷脂组合物及其制备方法和应用, 2016, 第 2 作者, 专利号: 201610128739.X

( 6 ) 一种用作非病毒基因载体的两亲性梳状SMA-PEI接枝共聚物及其制备方法和用途, 2016, 第 1 作者, 专利号: ZL 201210102333.6

( 7 ) 一种三嵌段聚合物、其制备方法及用途, 2015, 第 1 作者, 专利号: 201510412476.0

( 8 ) 一种盐酸伊立替康复合磷脂组合物、制备方法及其应用, 2015, 第 1 作者, 专利号: PCT/CN2015/073761

( 9 ) 一种疏水性药物琥珀布考纳米混悬液及其制备方法, 2015, 第 1 作者, 专利号: PCT/CN2015/072801

( 10 ) 紫杉醇-嵌段共聚物的偶联物、制备方法及其用途, 2014, 第 1 作者, 专利号: 201410427799.2

( 11 ) 聚阳离子包合物,其制备方法及用途, 2014, 第 1 作者, 专利号: 201410253432.3

( 12 ) 一种盐酸伊立替康复合磷脂组合物、制备方法及其应用, 2014, 第 1 作者, 专利号: 201410085842.1

( 13 ) 一种疏水性药物琥珀布考纳米混悬液及其制备方法, 2014, 第 1 作者, 专利号: 201410048877.8

( 14 ) 一种盐酸拓扑替康脂质体纳米制剂及其制备方法, 2014, 第 1 作者, 专利号: 201410016543.2

( 15 ) 一种用作靶向性输送紫杉醇的自组装纳米粒、其制备方法和用途, 2012, 第 1 作者, 专利号: 201210396408.6

( 16 ) 一种喹唑啉类分子靶向药物组合物及其制备方法, 2012, 第 1 作者, 专利号: 201210130265.4

( 17 ) 一种用作非病毒基因载体的两亲性梳状聚苯乙烯马来酸酐-聚乙烯亚胺接枝共聚物及其制备方法和用途, 2012, 第 1 作者, 专利号: 201210102333.6

( 18 ) 一种用于提高普罗布考口服吸收的多孔复合载药组合物, 2012, 第 1 作者, 专利号: 201210065776.2

( 19 ) 一种用作非病毒型基因载体的新型还原响应性阳离子聚合物及其制备方法和用途, 2010, 第 2 作者, 专利号: 201010540909.8

( 20 ) 一种可生物降解的非病毒基因载体及其制备方法和应用, 2010, 第 2 作者, 专利号: 201010279828.7

( 21 ) 坎地沙坦酯纳米乳及其制备方法, 2010, 第 1 作者, 专利号: 201010242672.5

( 22 ) 一种基于聚磷酸酯的用于脑内递药的药物传递系统, 2010, 第 1 作者, 专利号: 201010236321.3

( 23 ) 黄豆苷元固体脂质纳米粒及其制备方法, 2010, 第 1 作者, 专利号: 201010184999.1

( 24 ) 一种用作非病毒型基因载体的新型阳离子聚合物及其制备方法和用途, 2010, 第 1 作者, 专利号: 201010183750.9

( 25 ) 一种用作基因载体的壳聚糖衍生物及其制备方法和用途, 2010, 第 1 作者, 专利号: 201010183769.3

出版信息

   
发表论文
(1) Light-activated core-shell nanoparticles for spatiotemporally specific treatment of metastatic triple-negative breast cancer, ACS Nano, 2018, 通讯作者
(2) Tumor cells-selective bionic nano device exploiting heparanase combats metastatic breast cancer, Advanced Functional Materials, 2018, 通讯作者
(3) A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors, Nature Communications, 2018, 通讯作者
(4) Ly6Chi monocytes delivering pH-sensitive micelle loading paclitaxel improve targeting therapy of metastatic breast cancer, Adv Funct Mater, 2017, 通讯作者
(5) Albumin biomimetic nanocorona improves tumor targeting and penetration for synergistic therapy of metastatic breastcancer, Adv Funct Mater, 2017, 通讯作者
(6) Theranostic prodrug vesicles for reactive oxygen species-triggered ultrafast drug release and localregional therapy of metastatic triple negative breast cancer, Advanced Functional Materials, 2017, 通讯作者
(7) Programmed multi-responsive vesicles for enhanced tumor penetration and combination therapy of triple-negative breast cancer, Advanced Functional Materials, 2017, 通讯作者
(8) Inflammatory monocytes loading protease-sensitive nanoparticles enable lung metastasis targeting and intelligent drug release for anti-metastasis therapy, Nano Letters, 2017, 通讯作者
(9) Tumoral acidity-triggered ligand presentation nanoparticles combating the sequential drug delivery barriers for cancer therapy, Nano Letters, 2017, 通讯作者
(10) Tumoral acidity-triggered ligand presentation nanoparticles combating the sequential drug delivery barriers for cancer therapy, Nano Letters, 2017, 通讯作者
(11) Cancer cell membrane-coated gold nanocages with hyperthermia-triggered drug release and homotypic target inhibit growth and metastasis of breast cancer, Adv Funct Mater, 2016, 通讯作者
(12) Cancer cell-biomimetic nanoparticles for targeted therapy of homotypic tumors, Adv Mater, 2016, 通讯作者
(13) Versatile prodrug nanoparticles for acid-triggered precise imaging and organelle-specific combination cancer therapy, Adv Funct Mater, 2016, 通讯作者
(14) Bioinspired nanoparticles with NIR-controlled drug release for synergetic chemo-photothermal therapy of metastatic breast cancer, Adv Funct Mater, 2016, 通讯作者
(15) Acid-activatable versatile micelleplexes for PD-L1 blockade-enhanced cancer photodynamic immunotherapy, Nano Lett, 2016, 通讯作者
(16) Tumor microenvironment-adaptive nanoparticles co-deliver paclitaxel and siRNA to inhibit growth and lung metastasis of breast cancer, Adv Funct Mater, 2016, 通讯作者
(17) Liposome coated with isolated macrophage membrane can target lung metastasis of breast cancer, ACS Nano, 2016, 通讯作者
(18) Large pore-sized hollow mesoporous organosilica for redox-responsive gene delivery and synergistic cancer chemotherapy., Adv Mater 28(2016)1963-9, 2016, 通讯作者
(19) Long circulation RBC-mimetic nanoparticles with peptide-enhanced tumor penetration for simultaneously inhibiting growth and lung metastasis of breast cancer., Adv Funct Mater, 2016, 通讯作者
(20) Intracellularly acid-switchable multifunctional micelles for combinational photo/chemotherapy of drug resistant tumor., ACS Nano, 2016, 通讯作者
(21) Treatment of malignant brain tumor by tumor-triggered programmed wormlike micelles with precise targeting and deep penetration, Adv Funct Mater, 2016, 通讯作者
(22) Inhibition of metastasis and growth of breast cancer by pH-sensitive poly (β-amino ester) nanoparticles co-delivering two siRNA and paclitaxel., Biomaterials 48(2015)1-15, 2015, 通讯作者
(23) Large pore-sized ultrasmall mesoporous organosilica nanoparticles: micelle/precursor co-templating assembly and nuclear-targeted gene delivery., Adv Mater 27(2015)215-22., 2015, 通讯作者
(24) pH and near-Infrared light-responsive micelles with hyperthermia-triggered tumor penetration and cytoplasm drug release reverse doxorubicin resistance in breast cancer., Adv Funct Mater 25(2015)2489-500, 2015, 通讯作者
(25) Tumor-penetrating Nanotherapeutics Loading a Near-infrared Probe Inhibit Growth and Metastasis of Breast Cancer., Adv Funct Mater 25(2015)2831–9., 2015, 通讯作者
(26) Tumor-penetrating Nanotherapeutics Loading a Near-infrared Probe Inhibit Growth and Metastasis of Breast Cancer., Adv Funct Mater 25(2015)2831–9., 2015, 通讯作者
(27) Shrapnel nanoparticles loading docetaxel inhibit metastasis and growth of breast cancer., Biomaterials 64 (2015)10-20, 2015, 通讯作者
(28) The use of lipid-coated nanodiamond to improve bioavailability and efficacy of sorafenib in resisting metastasis of gastric cancer., Biomaterials 35(2014)4565-72, 2014, 通讯作者
(29) Co-delivery of doxorubicin and RNA using pH-sensitive poly (β-amino ester) nanoparticles for reversal of multidrug resistance of breast cancer., Biomaterials 35(2014):6047-59, 2014, 通讯作者
(30) Colloidal RBCs-shaped, hydrophilic and hollow mesoporous carbon nanocapsules for highly efficient biomedical engineering., Adv Mater 26(2014)4294-301, 2014, 通讯作者
(31) Hollow mesoporous rganosilica nanoparticles: a generic intelligent framework-hybridization approach for biomedicine., J Am Chem Soc 136(2014) 16326-34., 2014, 通讯作者
(32) The inhibition of metastasis and growth of breast cancer by blocking the NF-κB signaling pathway using bioreducible PEI-based/p65 shRNA complex nanoparticles, Biomaterials 34(2013):5381-90, 2013, 通讯作者
(33) Nanodiamonds-mediated doxorubicin nuclear delivery to inhibit lung metastasis of breast cancer, Biomaterials 34(2013):9648-56, 2013, 通讯作者
(34) A self-assembled nanocarrier loading teniposide improves the oral delivery and drug concentration in tumor., J Control Release 166(2013):30-7, 2013, 通讯作者
(35) Smart pH-sensitive and temporal-controlled polymeric micelles for effective combination therapy of doxorubicin and disulfiram., ACS Nano 7(2013):5858-69, 2013, 通讯作者
(36) Reversal of multidrug resistant by stimuli-responsive drug delivery systems for therapy of tumor., Adv Drug Deliv Rev 65(2013):1699-1715, 2013, 通讯作者
(37) Colloidal HPMO NPs:silica-etching chemistry tailoring, topological transformation and nano-biomedical applications., Adv Mater 25(2013):3100-5, 2013, 通讯作者
(38) Engineering inorganic nanoemulsions/nanoliposomes by fluoride-Silica chemistry for efficient delivery/co-delivery of hydrophobic agents, Adv Funct Mater 8(2012):1586–97, 2012, 通讯作者
(39) Downregulation of survivin expression and enhanced chemosensitivity of MCF-7 cells to Adriamycin by PDMAE/Survivin shRNA complex nanoparticles, Int J Pharm. 405 (2011)188-195, 2011, 通讯作者
(40) Reversal of multidrug resistance by reduction-sensitive linear cationic click polymer/iMDR1-pDNA complex nanoparticles, Biomaterials 32(2011)1738-1747, 2011, 通讯作者
(41) Nanoemulsion improves the oral absorption of candesartan cilexetil in rats: performance and mechanism, J Control Release 149 (2011)168-174, 2011, 通讯作者
(42) In vivo Biodistribution and Urinary Excretion of Mesoporous Silica Nanoparticles: Effects of Particle Size and PEGylation, Small 7(2011)271-280, 2011, 通讯作者
(43) Bioreducible poly (β-amino esters)/shRNA complex nanoparticles for efficient RNA delivery, J Control Release 151(2011) 35-44, 2011, 通讯作者
(44) A self-assembled nano-delivery system enhancing the oral bioavailability of daidzein: in vitro characteristics and in vivo performance, Nanomedicine UK (2011, in press), 2011, 通讯作者
(45) Solid lipid nanoparticles reduce systemic toxicity of docetaxel: performance and mechanism in animal, Nanotoxicology (2011,DOI: 10.3109/17435390.2010.551427 ), 2011, 通讯作者
(46) The linear cationic click polymers/DNA nanoparticles: in vitro structure-activity relationship and in vivo evaluation for gene delivery, Bioconjugate Chem 22 (2011) 1153-61, 2011, 通讯作者
(47) Daidzein-phospholipid complex loaded lipid nanocarriers improved oral absorption: in vitro characteristics and in vivo behavior in rats, Nanoscale 3(2011)1780 - 1787, 2011, 通讯作者
(48) A Novel Linear Cationic Click Polymer for Gene Delivery: Synthesis, Biocompatibility and In Vitro Transfection, Biomacromolecules 11 (2010) 3102-3111, 2010, 通讯作者
(49) Poly(ε-caprolactone)-block-poly(ethyl ethylene phosphate) micelles for brain targeting drug delivery: in vitro and in vivo valuation, Pharm. Res. 27 (2010), 2657-2669., 2010, 通讯作者
(50) The characteristics and mechanism of simvastatin loaded lipid nanoparticles to increase oral bioavailability in rats, Int J Pharm. 394(2010):147-53, 2010, 通讯作者
(51) Galactosylated poly(2-(2-aminoethyoxy)ethoxy)phosphazene/DNA complex nanoparticles: in vitro and in vivo evaluation for gene delivery, Biomacromolecules 11(2010):927-33, 2010, 通讯作者
(52) Galactosylated poly(2-(2-aminoethyoxy)ethoxy)phosphazene/DNA complex nanoparticles: in vitro and in vivo evaluation for gene delivery, Biomacromolecules 11(2010):927-33, 2010, 通讯作者
(53) Folate-PEG modified poly(2-(2-aminoethoxy)ethoxy)phosphazene /DNA nanoparticles for gene delivery: synthesis, preparation and in vitro transfection efficiency,  Int J Pharm. 392(2010):241-8, 2010, 通讯作者
(54) Effect of multifold charge groups and imidazole-4-carboxaldehyde on physicochemical characteristics and transfection of cationic polyphosphazenes/DNA complexes, Int J Pharm. 390(2010):191-7, 2010, 通讯作者
(55) Urocanic acid improves transfection efficiency of polyphosphazene with primary amino groups, Bioconjugate Chem 21 (2010) 419–426, 2010, 通讯作者
(56) Prostaglandin E1 encapsulated into lipid nanoparticles improves its anti-inflammatory effect with low side-effect, Int J Pharm. 387(2010)263-271, 2010, 通讯作者
(57) The characteristics and performance of a multifunctional nanoassembly system for the co-delivery of docetaxel and iSur-pDNA in a mouse hepatocellular carcinoma model, Biomaterials. 31(2010):916-22., 2010, 通讯作者
(58) Intelligent nanoassembly for gene delivery: In vitro transfection and the possible mechanism, Int J Pharm. 383 (2010):271-6, 2010, 通讯作者

科研活动

   
科研项目
( 1 ) 基于纳米技术的药物新剂型改善肿瘤治疗效果的应用基础研究, 负责人, 国家任务, 2010-01--2014-08
( 2 ) 基于纳米技术的抗癌药物新型递, 负责人, 国家任务, 2016-01--2021-12
( 3 ) 靶向治疗肿瘤的新型阳离子聚(β-氨基酯)/RNA 自组装纳米粒的研究, 负责人, 国家任务, 2013-01--2017-12
( 4 ) 纳米药物的产业化技术, 负责人, 中国科学院计划, 2013-07--2018-06
( 5 ) 基于红细胞膜的靶向纳米释药系统抗乳腺癌的肺转移研究, 负责人, 国家任务, 2017-01--2021-12
( 6 ) 生物大分子药物高效递释系统的药效与安全性, 负责人, 国家任务, 2017-01--2021-12
( 7 ) 基于红细胞膜的仿生纳米药物抗乳腺癌的肺转移, 负责人, 中国科学院计划, 2016-08--2020-12
参与会议
(1)RBC membrane coated nanoparticle for the treatment of breast cancer metastasis   2016海峡两岸生物医用材料与药物递送研讨会   2016-03-24
(2)用于肿瘤治疗的新型核酸输送载体   第三届中国小核酸技术与应用学术会议   李亚平   2011-04-26
(3)基于纳米技术的新药研究与开发   2010上海纳米科技发展专题研讨会   李亚平   2010-12-03
(4)基于纳米技术的新药基础和应用研究   中国微米纳米技术学会纳米科学技术分会-纳米生物与医药技术专业委员会2010学术会议   李亚平   2010-11-26
(5)纳米技术降低肿瘤耐药新策略   纳米科学技术分会第二届年会暨2010全国纳米生物与医学学术会议   李亚平   2010-11-04