刘佳佳  女  博导  中国科学院遗传与发育生物学研究所
电子邮件: jjliu@genetics.ac.cn
通信地址: 北京市朝阳区北辰西路1号院-2
邮政编码: 100101

研究领域

细胞内逆向囊泡运输及相关人类疾病的分子机理

招生信息

   
招生专业
071009-细胞生物学
071006-神经生物学
招生方向
细胞生物学
神经生物学

教育背景

   
学历
-- 研究生
学位
-- 博士

工作经历

2006至今,中国科学院遗传与发育生物学研究所,分子发育生物学中心

专利与奖励

国家杰出青年基金,2013年
中国科学院优秀导师奖,2013年

出版信息

   
发表论文
[1] 刘佳佳. Activity-dependent PI4P synthesis by PI4KIII regulates long-term synaptic potentiation. Cell Reports[J]. 2022, 38(9): 110452-, [2] 刘佳佳. Effect of disrupted episodic memory on food consumption: no impact of neuronal loss of Endophilin A1 on food intake and energy balance. J Genet Genomics[J]. 2022, 49(4): 329-337, [3] Yanrui Yang, JiaJia Liu. Structural LTP: Signal transduction, actin cytoskeleton reorganization, and membrane remodeling of dendritic spines. Current Opinion in Neurobiology[J]. 2022, 74: [4] 刘佳佳. Anterograde Viral Tracer HSV-1 Strain H129 Transports Primarily as Capsids in Cortical Neuron Axons.. Journal of Virology. 2020, [5] 刘佳佳. 神经元细胞器和囊泡运输. 中国细胞生物学学报[J]. 2019, 13-24, http://lib.cqvip.com/Qikan/Article/Detail?id=88669090504849574849484853.
[6] Niu, Yang, Dai, Zhanghua, Liu, Wenxue, Zhang, Cheng, Yang, Yanrui, Guo, Zhenzhen, Li, Xiaoyu, Xu, Chenchang, Huang, Xiahe, Wang, Yingchun, Shi, Yun S, Liu, JiaJia. Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory. ELIFE[J]. 2017, 6: https://doaj.org/article/4b6f4277c5a84bc68b077cc88507ad6c.
[7] Sun, Qingxiang, Yong, Xin, Sun, Xiaodong, Yang, Fan, Dai, Zhonghua, Gong, Yanqiu, Zhou, Liming, Zhang, Xia, Niu, Dawen, Dai, Lunzhi, Liu, JiaJia, Jia, Da. Structural and functional insights into sorting nexin 5/6 interaction with bacterial effector IncE. SIGNAL TRANSDUCTION AND TARGETED THERAPY[J]. 2017, 2: https://www.webofscience.com/wos/woscc/full-record/WOS:000454603800021.
[8] Guan, Liying, Ma, Xuehua, Zhang, Jingyan, Liu, JiaJia, Wang, Yingchun, Ding, Mei. The Calponin Family Member CHDP-1 Interacts with Rac/CED-10 to Promote Cell Protrusions. PLOS GENETICS[J]. 2016, 12(7): http://www.corc.org.cn/handle/1471x/2375275.
[9] Liu, JiaJia. Retromer-Mediated Protein Sorting and Vesicular Trafficking. JOURNAL OF GENETICS AND GENOMICSnull. 2016, 43(4): 165-177, http://dx.doi.org/10.1016/j.jgg.2016.02.006.
[10] Xu, Chenchang, Fu, Xiuping, Zhu, Shaoxia, Liu, JiaJia. Retrolinkin recruits the WAVE1 protein complex to facilitate BDNF-induced TrkB endocytosis and dendrite outgrowth. MOLECULAR BIOLOGY OF THE CELL[J]. 2016, 27(21): 3342-3356, https://www.webofscience.com/wos/woscc/full-record/WOS:000387389000022.
[11] Yang, Yanrui, Wei, Mengping, Xiong, Ying, Du, Xiangyang, Zhu, Shaoxia, Yang, Lin, Zhang, Chen, Liu, JiaJia. Endophilin A1 regulates dendritic spine morphogenesis and stability through interaction with p140Cap. CELL RESEARCH[J]. 2015, 25(4): 496-516, https://www.webofscience.com/wos/woscc/full-record/WOS:000353917200007.
[12] Li, Ke, Yang, Lin, Zhang, Cheng, Niu, Yang, Li, Wei, Liu, JiaJia. HPS6 interacts with dynactin p150(Glued) to mediate retrograde trafficking and maturation of lysosomes. JOURNAL OF CELL SCIENCE[J]. 2014, 127(21): 4574-4588, https://www.webofscience.com/wos/woscc/full-record/WOS:000344848700005.
[13] 张程, 牛洋, 刘佳佳. 囊泡运输的功能与调控机制. 中国细胞生物学学报[J]. 2014, 36(9): 1218-1226, [14] Niu, Yang, Zhang, Cheng, Sun, Zhe, Hong, Zhi, Li, Ke, Sun, Demeng, Yang, Yanrui, Tian, Changlin, Gong, Weimin, Liu, JiaJia. PtdIns(4)P regulates retromer-motor interaction to facilitate dynein-cargo dissociation at the trans-Golgi network. NATURE CELL BIOLOGY[J]. 2013, 15(4): 417-+, http://www.irgrid.ac.cn/handle/1471x/756652.
[15] Fu, Xiuping, Yang, Yanrui, Xu, Chenchang, Niu, Yang, Chen, Tielin, Zhou, Qin, Liu, JiaJia. Retrolinkin cooperates with endophilin A1 to mediate BDNF-TrkB early endocytic trafficking and signaling from early endosomes. MOLECULAR BIOLOGY OF THE CELL[J]. 2011, 22(19): 3684-3698, https://www.webofscience.com/wos/woscc/full-record/WOS:000295367400012.
[16] Zhi Hong, Yanrui Yang, Cheng Zhang, Yang Niu, Ke Li, Xi Zhao, Jia-JiaLiu. The retromer component SNX6 interacts with dynactin p150Glued and mediates endosome-to-TGN transport. 细胞研究:英文版. 2009, 1334-1349, http://lib.cqvip.com/Qikan/Article/Detail?id=32430424.
[17] Xiao, Hui, Chen, Didi, Fang, Zhou, Xu, Jing, Sun, Xiaojuan, Song, Song, Liu, Jiajia, Yang, Chonglin. Lysosome Biogenesis Mediated by vps-18 Affects Apoptotic Cell Degradation in Caenorhabditis elegans. MOLECULAR BIOLOGY OF THE CELL[J]. 2009, 20(1): 21-32, http://www.corc.org.cn/handle/1471x/2395196.
[18] Hong, Zhi, Yang, Yanrui, Zhang, Cheng, Niu, Yang, Li, Ke, Zhao, Xi, Liu, JiaJia. The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport. CELL RESEARCH[J]. 2009, 19(12): 1334-1349, http://lib.cqvip.com/Qikan/Article/Detail?id=32430424.

科研活动

   
科研项目
(1) SNX6 介导的囊泡运输中retromer-motor 运输复合体的组装及,主持,国家级,2015-01--2018-12
(2) 神经元迁移、形态发生和微环路形成的调控机制,参与,国家级,2014-01--2018-12
(3) 细胞生物学,主持,国家级,2014-01--2017-12
(4) SNX6在胞内体到高尔基体囊泡运输中的功能研究 ,主持,国家级,2011-01--2013-12
(5) 科研-重大神经发育缺陷的发生机制和可控性-4,参与,院级级,2011-01--2013-12
(6) 科研-三维培养干细胞的定向分化调控网络研究,主持,国家级,2010-01--2015-12
(7) retrolinkin在神经元细胞内吞和囊泡运输中的功能研究 ,主持,国家级,2009-01--2012-12

指导学生

已指导学生

洪智  博士研究生  071009-细胞生物学  

武昌杰  博士研究生  071009-细胞生物学  

赵希  硕士研究生  071009-细胞生物学  

付秀萍  博士研究生  071009-细胞生物学  

李轲  博士研究生  071009-细胞生物学  

杜向阳  硕士研究生  071007-遗传学  

宋亚坤  硕士研究生  085238-生物工程  

现指导学生

徐晨昶  博士研究生  071009-细胞生物学  

牛洋  博士研究生  071009-细胞生物学  

刘畅  博士研究生  071009-细胞生物学  

王居伟  博士研究生  071006-神经生物学  

郭真真  博士研究生  071006-神经生物学