基本信息
俞飚 男 博导 中国科学院上海有机化学研究所
电子邮件： byu@sioc.ac.cn
通信地址： 上海市徐汇区零陵路345号1-306室
邮政编码： 200032
电子邮件： byu@sioc.ac.cn
通信地址： 上海市徐汇区零陵路345号1-306室
邮政编码： 200032
研究领域
具有重要生理活性的复杂寡糖、糖缀合物及其它天然产物的全合成、合成方法学和化学生物学。
招生信息
招生专业
070303-有机化学
招生方向
生命有机化学，糖化学
教育背景
1992-09--1995-07 中科院上海有机所 博士
1989-09--1992-07 中科院上海有机所 硕士
1985-09--1989-07 北京大学技术物理系 学士
1989-09--1992-07 中科院上海有机所 硕士
1985-09--1989-07 北京大学技术物理系 学士
工作经历
工作简历
1999-12--今 中科院上海有机所 研究员
1997-09--1999-11 中科院上海有机所 副研究员
1996-09--1997-08 中科院上海有机所 助理研究员
1995-09--1996-08 美国纽约大学化学系 博士后
1997-09--1999-11 中科院上海有机所 副研究员
1996-09--1997-08 中科院上海有机所 助理研究员
1995-09--1996-08 美国纽约大学化学系 博士后
社会兼职
2013-09--今 上海科技大学，教授
2010-09--今 上海高校E-化学生物学研究院，特聘研究员
2009-09--今 华东理工大学，特聘讲座教授
2004-09--今 中国科学技术大学，博师生导师
2010-09--今 上海高校E-化学生物学研究院，特聘研究员
2009-09--今 华东理工大学，特聘讲座教授
2004-09--今 中国科学技术大学，博师生导师
教授课程
天然产物合成的战略与战术化学小分子全合成与化学生物学现代有机合成与设计
专利与奖励
奖励信息
（1） 张树政糖科学杰出成就奖, 一等奖, 其他, 2019（2） Fellow of the Royal Society of Chemistry, 其他, 2016（3） “万人计划”第一批科技创新领军人才, , 部委级, 2014（4） 中科院朱李月华优秀教师奖, 部委级, 2014（5） 上海市首届青年科技杰出贡献奖, 一等奖, 省级, 2013（6） 创新人才推进计划中青年科技创新领军人才, 部委级, 2013（7） 上海市自然科学牡丹奖, 一等奖, 省级, 2012（8） 国家自然科学奖, 二等奖, 国家级, 2010（9） 上海市自然科学奖, 二等奖, 省级, 2006
专利成果
[1] 王任小, 柳红, 俞飚, 李杨峰, 李淳朴, 李嫣, 周宓, 李晴, 苏敏仪. 一种苯基吡唑类化合物、药物组合物、其制备方法及应用. CN: CN110746355B, 2023-08-11.[2] 王任小, 郭春, 俞飚, 李杨峰, 李嫣, 安然, 徐耀春, 周宓, 李晴, 孔文娜, 李婕. 一种噻唑酰胺类化合物、其制备方法、药物组合物及应用. CN: CN108947931B, 2023-07-07.[3] 王婧, 郭敏, 房鹏飞, 俞飚, 赵之欣. 芳香环类药物在抑制恶性黑色素瘤关键转录因子方面的应用. CN: CN107233340B, 2023-07-07.[4] 刘钧, 伊曼纽尔·达坦, 马丁·吉尔伯特·波姆珀, 伊尔·米恩, 徐鹏, 俞飚. 葡萄糖雷公藤甲素缀合物及其用途. US: CN115715201A, 2023-02-24.[5] 房鹏飞, 周金通, 王婧, 俞飚. 一种用于抑制赖氨酰tRNA合成酶的芳香环类化合物. CN: CN115109034A, 2022-09-27.[6] 俞飚, 党永军, 裴成锋, 王瑞娜, 张夏衡, 蒋维, 马君君, 李增霞, 陈小平, 刘超, 马玉勇, 徐鹏. 化合物P57或其类似物用于体温降低和神经保护的用途. CN: CN114075260A, 2022-02-22.[7] 俞飚, 党永军, 裴成锋, 王瑞娜, 张夏衡, 蒋维, 马君君, 李增霞, 陈小平, 刘超, 马玉勇, 徐鹏. 孕甾皂苷P57及其衍生物的中间体、制备方法和用途、及孕甾皂苷P57衍生物. CN: CN114075261A, 2022-02-22.[8] 俞飚, 邵笑飞, 徐鹏. 一种甘露糖醛酸寡糖的制备方法及其中间体. CN: CN113527374A, 2021-10-22.[9] 房鹏飞, 王婧, 周金通, 俞飚. 一种芳香环类化合物用于抑制赖氨酰tRNA合成酶的用途. CN: CN113135894A, 2021-07-20.[10] 王任小, 柳红, 俞飚, 李杨峰, 李淳朴, 李嫣, 周宓, 李晴, 苏敏仪. 一种苯基吡唑类化合物、药物组合物、其制备方法及应用. CN: CN110746355A, 2020-02-04.[11] 党永军, 汤其群, 俞飚, 刘钧, 崔照盟, 刘洋, 李微. 依他尼酸在制备治疗和预防肥胖及相关代谢性疾病药物中的应用. CN: CN109172559A, 2019-01-11.[12] 王婧, 郭敏, 房鹏飞, 俞飚, 赵之欣. Use of Aromatic Ring Drug in Inhibiting Key Transcription Factor of Malignant Melanoma. US11077097B2, 2018-06-04.[13] 王婧, 郭敏, 房鹏飞, 俞飚, 赵之欣. 芳香环类药物在抑制恶性黑色素瘤关键转录因子方面的应用. CN: CN107281171A, 2017-10-24.[14] 王婧, 郭敏, 房鹏飞, 俞飚, 赵之欣. 芳香环类药物在抑制恶性黑色素瘤关键转录因子方面的应用. CN: CN107233340A, 2017-10-10.[15] 曹鑫, 俞飚, 汪宁, 陈俊威. 一种视黄酸类化合物、其制备方法、中间体及应用. CN: CN107176945A, 2017-09-19.[16] 俞飚, 徐鹏, 许伟长, 石富春, 连高焱, 李原强, 车大庆, 严普查. 一种糖胺聚糖类化合物N,O-同时硫酸化的方法及其反应中间体. CN: CN104592319A, 2015-05-06.[17] 俞飚, 谢欣, 张书永, 马玉勇, 李静, 马君君. 果同尼皂苷F及其衍生物的中间体、制备方法和用途及果同尼皂苷F衍生物. CN: CN103755762A, 2014-04-30.[18] 俞飚, 孙建松, 牛一鸣, 李荣耀. 一种原人参三醇类人参皂苷的制备方法. CN: CN103360442A, 2013-10-23.[19] 王任小, 俞飚, 周炳城, 刘真, 徐耀春. 一种葡萄糖苷类化合物的制备方法及应用. CN: CN103087122A, 2013-05-08.[20] 张卫东, 俞飚, 单磊, 孙建松, 苏娟, 曹文杰, 沈云亨, 田均勉. 皂苷化合物及其制备方法与在制备免疫佐剂中的应用. CN: CN102382154A, 2012-03-21.[21] 俞飚, 孙建松, 牛一鸣, 廖进喜. 一种20位接糖的原人参三醇类人参皂苷及类似物的合成方法. CN: CN102336800A, 2012-02-01.[22] 王任小, 俞飚, 史合方, 李勋, 周炳城, 李嫣, 石志敏, 张兴龙, 朱翠侠, 李雯雯. 2-芳基-6-芳基'-葡萄糖苷类化合物及其制备方法与应用. CN: CN101348509B, 2011-12-07.[23] 俞飚, 孙建松, 张庆举, 李瑶. 一种嘧啶类核苷化合物或嘌呤类核苷化合物的制备方法. CN: CN102127135A, 2011-07-20.[24] 俞飚, 李瑶. 糖基聚醚、制备方法及用途. CN: CN101792524A, 2010-08-04.[25] 俞飚, 彭文杰. 虎眼万年青OSW-1皂甙的无A、B环的双环类似物、合成方法和用途. CN: CN101089008B, 2010-05-19.[26] 王任小, 俞飚, 李勋, 周炳城, 石志敏, 张兴龙, 朱翠侠, 李雯雯. 一种噻唑并3,2－a嘧啶类化合物及其作为Bcl－2家族蛋白拮抗剂的应用. CN: CN101348495A, 2009-01-21.[27] 俞飚, 魏国. 3－芳基－8－羟基色原酮－7－O－α－D－呋喃阿拉伯糖苷化合物及其合成方法和用途. CN: CN101279993A, 2008-10-08.[28] 李明, 俞飚. 甲基或乙基原薯蓣皂苷的化学合成方法. CN: CN1331879C, 2007-08-15.[29] 俞飚, 彭文杰, 林峰, 韩秀文. 葡萄糖醛酸苷齐墩果烷型双糖链三萜皂甙的化学合成. CN: CN1295246C, 2007-01-17.[30] 李明, 俞飚. 呋甾皂苷及其衍生物的化学合成方法. CN: CN1763076A, 2006-04-26.[31] 俞飚, 史炳锋. 虎眼万年青皂甙OSW－1类型皂甙的23位杂原子取代的类似物及其合成方法和用途. CN: CN1247610C, 2006-03-29.[32] 俞飚, 惠永正, 李兵, 邢国文. 鼠李糖取代的β－D－葡萄糖基－薯蓣皂甙的皂甙库、制备方法和用途. CN: CN1115346C, 2003-07-23.[33] 俞飚, 邢国文, 惠永正. 薯蓣皂甙的酰基化衍生物、制备方法及用途. CN: CN1322729A, 2001-11-21.[34] 俞飚, 惠永正, 邢国文, 李兵. 一种利用一步或两步随机化反应制备皂甙库的方法. CN: CN1293200A, 2001-05-02.[35] 俞飚, 惠永正, 李兵. 一种合成具有2,4－0－二取代葡萄糖基糖链的皂甙的方法. CN: CN1291614A, 2001-04-18.[36] 田庚元, 惠永正, 孙孝先, 俞飚, 李寿桐. 果聚糖同系混合物的药物、生产方法及其用途. CN: CN1101833A, 1995-04-26.
出版信息
发表论文
[1] Elgehama, Ahmed, Wang, Yixuan, Yu, Ying, Zhou, Lin, Chen, Zhixiu, Wang, Liwei, Sun, Lijun, Gao, Jian, Yu, Biao, Shen, Yan, Xu, Qiang. Targeting the PTP1B-Bcr-Abl1 interaction for the degradation of T315I mutant Bcr-Abl1 in chronic myeloid leukemia. CANCER SCIENCE[J]. 2023, 第 9 作者114(1): 247-258, http://dx.doi.org/10.1111/cas.15580.[2] 刘威, 王自强, Tayyab Gulzar, 张笑东, 丁国平, 徐鹏, 俞飚. 4-(2′-Phenylethynylphenyl)phenyl glycosides as glycosylation donors. Pure Appl. Chem.[J]. 2023, 第 7 作者 通讯作者 https://www.degruyter.com/document/doi/10.1515/pac-2022-1114/html.[3] Liu, Zijing, Liu, Dan, Zhu, Dapeng, Yu, Biao. Stereoselective Synthesis of & beta;-glycosyl Esters via 1-Hydroxybenzotriazole Mediated Acylation of Glycosyl Hemiacetals. ORGANIC LETTERS[J]. 2023, 第 4 作者 通讯作者 25(28): 5372-5377, http://dx.doi.org/10.1021/acs.orglett.3c01750.[4] Yang, Fuzhu, Sun, Yishan, Xu, Peng, Molinaro, Antonio, Silipo, Alba, Yu, Biao. Synthesis of Unprecedented alpha/beta-Alternate (1 -> 4)-Glucans via Stereoselective Iterative Glycosylation. CHEMISTRY-A EUROPEAN JOURNAL. 2023, 第 6 作者 通讯作者 http://dx.doi.org/10.1002/chem.202300659.[5] 刘威, 胡志飞, 徐鹏, 俞飚. Synthesis of Anticoagulant Pentasaccharide Fondaparinux via 3,5‑Dimethyl-4-(2′-phenylethynylphenyl)phenyl Glycosides. Organic Letters[J]. 2023, 第 4 作者 通讯作者 https://pubs.acs.org/doi/10.1021/acs.orglett.3c03484.[6] 杨馥竹, 孙一珊, 徐鹏, Antonio Molinaro, Alba Silipo, 俞飚. Synthesis of Unprecedented α/β-Alternate (1→4)-Glucans via Stereoselective Iterative Glycosylation.. Chemistry - A European Journal[J]. 2023, 第 6 作者 通讯作者 https://chemistry-europe.onlinelibrary.wiley.com/journal/15213765.[7] Xia, Yan, Wang, Yingjie, Zhang, Zhaolun, Gulzar, Tayyab, Lin, Yuqi, Wang, Jing, Zhu, Dapeng, Yu, Biao. Synthesis of 2-Indolyl C -Glycoside Neopetrosins A and C and Congeners via Ni-Catalyzed Photoreductive Cross-Coupling. ORGANIC LETTERS[J]. 2023, 第 8 作者 通讯作者 25(36): 6741-6745, http://dx.doi.org/10.1021/acs.orglett.3c02601.[8] 代元伟, 刘威, 徐鹏, 俞飚. 肝素三糖和四糖衍生物的高立体选择性合成. 中国科学:化学[J]. 2023, 第 4 作者53(3): 529-536, http://lib.cqvip.com/Qikan/Article/Detail?id=7109220340.[9] Yang, Fuzhu, Hou, Wu, Zhu, Dapeng, Tang, Yu, Yu, Biao. A Stereoselective Glycosylation Approach to the Construction of 1,2-trans-beta-D-Glycosidic Linkages and Convergent Synthesis of Saponins. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2022, 第 5 作者 通讯作者 28(7): http://dx.doi.org/10.1002/chem.202104002.[10] Zhu, Dapeng, Geng, Mingyu, Yu, Biao. Total Synthesis of Starfish Cyclic Steroid Glycosides. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2022, 第 3 作者 通讯作者 61(24): http://dx.doi.org/10.1002/anie.202203239.[11] Liu, Xianglai, Lin, Yetong, Liu, Ao, Sun, Qianhui, Sun, Huiyong, Xu, Peng, Li, Guolong, Song, Yingying, Xie, Weijia, Sun, Haopeng, Yu, Biao, Li, Wei. 2-Diphenylphosphinonyl-acetyl as a Remote Directing Group for the Highly Stereoselective Synthesis of beta-Glycosides. CHINESE JOURNAL OF CHEMISTRY[J]. 2022, 第 11 作者40(4): 443-452, http://dx.doi.org/10.1002/cjoc.202100865.[12] 俞飚. Tri(N‑carbazolyl)phosphine Gold(I) Complexes: Structural and Catalytic Activity Studies. Inorganic Chemistry[J]. 2022, 第 1 作者 通讯作者 [13] Cao, Xin, Du, Xiaojing, Jiao, Heng, An, Quanlin, Chen, Ruoxue, Fang, Pengfei, Wang, Jing, Yu, Biao. Carbohydrate-based drugs launched during 2000-2021. ACTA PHARMACEUTICA SINICA B. 2022, 第 8 作者 通讯作者 12(10): 3783-3821, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7343026&detailType=1.[14] 俞飚. A Stereoselective Glycosylation Approach to the Construction of 1,2-trans-β-d-Glycosidic Linkages and Convergent Synthesis of Saponins. Chemistry - A European Journal[J]. 2022, 第 1 作者 通讯作者 [15] Wang, Shengyang, Yang, You, Zhu, Qian, Lin, GuoQiang, Yu, Biao. Chemical synthesis of polysaccharides. CURRENT OPINION IN CHEMICAL BIOLOGY. 2022, 第 5 作者 通讯作者 69: http://dx.doi.org/10.1016/j.cbpa.2022.102154.[16] 俞飚. GeCl2·Dioxane−AgBF4 Catalyzed Activation of Glycosyl Fluorides for Glycosylation. Organic Letters[J]. 2022, 第 1 作者 通讯作者 [17] 张鑫, 徐鹏, 俞飚. Chemical Synthesis of a Colanic Acid Hexasaccharide. Organic Letters[J]. 2022, 第 3 作者 通讯作者 24: 7779-7783, https://pubs.acs.org/doi/10.1021/acs.orglett.2c03116.[18] 俞飚. Total Synthesis and Stereochemistry Assignment of Nucleoside Antibiotic A-94964. Angewandte Chemie International Edition[J]. 2022, 第 1 作者 通讯作者 [19] 侯武, 曹鑫, 徐鹏, 俞飚. Total syntheses of wentilactones A and B, and related norditerpene dilactones. Chemical Communications[J]. 2022, 第 4 作者 通讯作者 58: 12487-12490, https://pubs.rsc.org/en/content/articlelanding/2022/CC/D2CC04930A.[20] Ye, Farong, Zhao, Jie, Xu, Peng, Liu, Xinliang, Yu, Jing, Shangguan, Wei, Liu, Jiazhi, Luo, Xiaosheng, Li, Cheng, Ying, Tianlei, Wang, Jing, Yu, Biao, Wang, Ping. Synthetic Homogeneous Glycoforms of the SARS-CoV-2 Spike Receptor-Binding Domain Reveals Different Binding Profiles of Monoclonal Antibodies. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 第 12 作者60(23): 12904-12910, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251112/.[21] Tong, Lu, Zhao, Qunfei, Datan, Emmanuel, Lin, GuoQiang, Minn, Il, Pomper, Martin G, Yu, Biao, Romo, Daniel, He, QingLi, Liu, Jun O. Triptolide: reflections on two decades of research and prospects for the future. NATURAL PRODUCT REPORTS. 2021, 第 7 作者38(4): 843-860, http://dx.doi.org/10.1039/d0np00054j.[22] Onodera, Toshiharu, Zadeh, Ebrahim Ghazvini, Xu, Peng, Gordillo, Ruth, Guo, Zheng, Joffin, Nolwenn, Yu, Biao, Scherer, Philipp E, Li, Wenhong. PEGylated AdipoRon derivatives improve glucose and lipid metabolism under insulinopenic and high-fat diet conditions. JOURNAL OF LIPID RESEARCH[J]. 2021, 第 7 作者62: http://dx.doi.org/10.1016/j.jlr.2021.100095.[23] Zhou, Qian, Chen, Wensheng, Fan, Zhenzhen, Chen, Zhipeng, Liang, Jinxia, Zeng, Guandi, Liu, Lu, Liu, Wanting, Yang, Tong, Cao, Xin, Yu, Biao, Xu, Meng, Chen, YeGuang, Chen, Liang. Targeting hyperactive TGFBR2 for treating MYOCD deficient lung cancer. THERANOSTICS[J]. 2021, 第 11 作者11(13): 6592-6606, http://dx.doi.org/10.7150/thno.59816.[24] Xu, Peng, Yu, Biao. Chemical synthesis of saponins: An update. ADVANCES IN CARBOHYDRATE CHEMISTRY AND BIOCHEMISTRY, VOL 79[J]. 2021, 第 2 作者 通讯作者 79: 1-62, [25] Nicolardi, Simone, Joseph, A Abragam, Zhu, Qian, Shen, Zhengnan, PardoVargas, Alonso, Chiodo, Fabrizio, Molinaro, Antonio, Silipo, Alba, van der Burgt, Yuri E M, Yu, Biao, Seeberger, Peter H, Wuhrer, Manfred. Analysis of Synthetic Monodisperse Polysaccharides by Wide Mass Range Ultrahigh-Resolution MALDI Mass Spectrometry. ANALYTICAL CHEMISTRY[J]. 2021, 第 10 作者93(10): 4666-4675, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034773/.[26] Elgehama, Ahmed, Sun, Lijun, Yu, Biao, Guo, Wenjie, Xu, Qiang. Selective targeting of the androgen receptor-DNA binding domain by the novel antiandrogen SBF-1 and inhibition of the growth of prostate cancer cells. INVESTIGATIONAL NEW DRUGS[J]. 2021, 第 3 作者39(2): 442-457, http://dx.doi.org/10.1007/s10637-020-01050-w.[27] Wang, Ziqiang, Wei, Bingcheng, Mu, Tong, Xu, Peng, Yu, Biao. Facile Synthesis of Saikosaponins. MOLECULES[J]. 2021, 第 5 作者 通讯作者 26(7): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000638726800001.[28] Yu, Biao, Wang, Shengyang. Solving the Structural Puzzles of Amipurimycin and Miharamycins Enabled by Stereodivergent Total Synthesis. CHEMICAL RECORD[J]. 2021, 第 1 作者 通讯作者 21(11): 3015-3028, http://dx.doi.org/10.1002/tcr.202100057.[29] Fu, Jiqiang, Xu, Peng, Yu, Biao. Total Synthesis of Nucleoside Antibiotics Amicetin, Plicacetin, and Cytosaminomycin A-D. CHINESE JOURNAL OF CHEMISTRY[J]. 2021, 第 3 作者 通讯作者 39(10): 2679-2684, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7100450&detailType=1.[30] Tang, Yu, Reddy, D Prabhakar, Yu, Biao. A dehydrative glycosylation protocol mediated by nonafluorobutanesulfonyl fluoride (NfF). TETRAHEDRON[J]. 2021, 第 3 作者 通讯作者 78: http://dx.doi.org/10.1016/j.tet.2020.131800.[31] Mu, Tong, Xu, Peng, Yu, Biao. 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Efficient synthesis of kaempferol 3,7-O-bisglycosides via successive glycosylation with glycosyl ortho-alkynylbenzoates and trifluoroacetimidates. TETRAHEDRON LETTERS[J]. 2012, 第 6 作者53(22): 2773-2776, http://dx.doi.org/10.1016/j.tetlet.2012.03.103.[169] Tang, Yu, Yu, Biao. Identification of (phosphine)gold(I) hydrates and their equilibria in wet solutions. RSC ADVANCES[J]. 2012, 第 2 作者2(33): 12686-12689, http://dx.doi.org/10.1039/c2ra22282e.[170] Zhang, Jigang, Cao, Wenjie, Tian, Junmian, Yue, Rongcai, Li, Li, Guo, Baoyu, Shan, Lei, Yu, Biao, Zhang, Weidong. Evaluation of novel saponins from Psammosilene tunicoides and their analogs as immunomodulators. INTERNATIONAL IMMUNOPHARMACOLOGY[J]. 2012, 第 8 作者14(1): 21-26, http://dx.doi.org/10.1016/j.intimp.2012.06.006.[171] Mu-Yang Wang, Xue-Ting Liu, Ying Chen, Xiao-Jing Xu, Biao Yu, Shu-Qun Zhang, Qun Li, Zu-Hua He. 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JOURNAL OF ORGANIC CHEMISTRY[J]. 2008, 第 3 作者 通讯作者 73(13): 4978-4985, http://www.irgrid.ac.cn/handle/1471x/587827.[223] Zha, Manwu, Guo, Qing, Zhang, Yichun, Yu, Biao, Ou, Ying, Zhong, Chen, Ding, Jianping. Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies. JOURNAL OF MOLECULAR BIOLOGY[J]. 2008, 第 4 作者379(3): 568-578, http://dx.doi.org/10.1016/j.jmb.2008.04.006.[224] Ong, Rose C Y, Lei, Jin, Lee, Rebecca K Y, Cheung, Jenny Y N, Fung, K P, Lin, Chinlon, Ho, H P, Yu, Biao, Li, Ming, Kong, S K. Polyphyllin D induces mitochondrial fragmentation and acts directly on the mitochondria to induce apoptosis in drug-resistant HepG2 cells. CANCER LETTERS[J]. 2008, 第 8 作者261(2): 158-164, http://dx.doi.org/10.1016/j.canlet.2007.11.005.[225] Chen, Jianfang, Zhou, Ying, Chen, Chen, Xu, Weichang, Yu, Biao. Synthesis of a tetrasaccharide substrate of heparanase. CARBOHYDRATE RESEARCH[J]. 2008, 第 5 作者 通讯作者 343(17): 2853-2862, http://dx.doi.org/10.1016/j.carres.2008.06.011.[226] Zhu, Chunsheng, Tang, Pingping, Yu, Biao. Total synthesis of lobatoside E, a potent antitumor cyclic triterpene saponin. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2008, 第 3 作者 通讯作者 130(18): 5872-+, http://www.irgrid.ac.cn/handle/1471x/587833.[227] 李微, 邱早早, 王一兵, 张一纯, 李明, 于佳, 张立红, 朱自严, 俞飚. Synthesis, cytotoxicity, and hemolytic activity of 6’-O-substituted dioscin derivatives.. CARBOHYDR. RES.[J]. 2007, 第 9 作者342(18): 2705-2715, http://ir.sioc.ac.cn/handle/331003/19065.[228] Li, Wei, Qiu, Zaozao, Wang, Yibing, Zhang, Yichun, Li, Ming, Yu, Jia, Zhang, Lihong, Zhu, Ziyan, Yu, Biao. Synthesis, cytotoxicity, and hemolytic activity of 6 '-O-substituted dioscin derivatives. CARBOHYDRATE RESEARCH[J]. 2007, 第 9 作者 通讯作者 342(18): 2705-2715, http://dx.doi.org/10.1016/j.carres.2007.09.004.[229] Wang, Ziyu, Li, Ming, Liu, Xueting, Yu, Biao. Synthesis of steroidal saponins bearing an aromatic E ring. TETRAHEDRON LETTERS[J]. 2007, 第 4 作者 通讯作者 48(41): 7323-7326, http://dx.doi.org/10.1016/j.tetlet.2007.08.028.[230] 俞飚, 张一纯, 汤平平. Carbohydrate chemistry in the total synthesis of saponins.. EUR. J. ORG. CHEM.[J]. 2007, 第 1 作者5145-5161, http://ir.sioc.ac.cn/handle/331003/19067.[231] Tang, Pingping, Yu, Biao. Total synthesis of candicanoside A, a potent antitumor saponin with a rearranged steroid side chain. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2007, 第 2 作者 通讯作者 46(14): 2527-2530, http://www.irgrid.ac.cn/handle/1471x/587820.[232] Yu, Biao, Zhang, Yichun, Tang, Pingping. Carbohydrate chemistry in the total synthesis of Saponins. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2007, 第 1 作者 通讯作者 2007(31): 5145-5161, http://ir.sioc.ac.cn/handle/331003/19067.[233] Wang, Yibing, Zhang, Yichun, Zhu, Ziyan, Zhu, Shilei, Li, Yingxia, Li, Ming, Yu, Biao. Exploration of the correlation between the structure, hemolytic activity, and cytotoxicity of steroid saponins. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2007, 第 11 作者15(7): 2528-2532, http://dx.doi.org/10.1016/j.bmc.2007.01.058.[234] Peng, Wenjie, Tang, Pingping, Hu, Xiaoyi, Liu, Jun O, Yu, Biao. Synthesis of the A,B-ring-truncated OSW saponin analogs and their antitumor activities. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2007, 第 11 作者17(20): 5506-5509, http://dx.doi.org/10.1016/j.bmcl.2007.08.060.[235] Wang, Yibing, Zhang, Yichun, Yu, Biao. The cytotoxicity of Saponins correlates with their cellular internalization. CHEMMEDCHEM[J]. 2007, 第 3 作者2(3): 288-+, http://www.irgrid.ac.cn/handle/1471x/587818.[236] Tang, Pingping, Mamdani, Fatemah, Hu, Xiaoyi, Liu, Jun O, Yu, Biao. Synthesis of OSW saponin analogs with modified sugar residues and their antiproliferative activities. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2007, 第 11 作者17(4): 1003-1007, http://dx.doi.org/10.1016/j.bmcl.2006.11.032.[237] Yang, You, Yu, Biao. N-Dimethylphosphoryl-protection in the efficient synthesis of glucosamine-containing oligosaccharides with alternate N-acyl substitutions. TETRAHEDRON LETTERS[J]. 2007, 第 11 作者48(39): 7049-7052, http://dx.doi.org/10.1016/j.tetlet.2007.07.108.[238] Yang, You, Yu, Biao. N-dimethylphosphoryl-protected glucosamine trichloroacetimidate as an effective glycosylation donor. TETRAHEDRON LETTERS[J]. 2007, 第 11 作者48(26): 4557-4560, http://dx.doi.org/10.1016/j.tetlet.2007.04.150.[239] Liu, XueTing, Shi, Yao, Yu, Biao, Williams, Ian D, Sung, Herman H Y, Zhang, Qiong, Liang, JingYu, Ip, Nancy Y, Min, ZhiDa. Antibacterial diterpenoids from Sagittaria pygmaea. PLANTA MEDICA[J]. 2007, 第 3 作者73(1): 84-90, http://www.irgrid.ac.cn/handle/1471x/587822.[240] 李英霞, 张一纯, 郭甜甜, 管华诗, 郝妍, 俞飚. Synthesis of the cytotoxic gitogenin 3β-O-2-O-(α-L-rhamnopyranosyl) -β-D-galactopyranoside and its congeners.. SYNTHESIS[J]. 2006, 第 6 作者775-782, http://ir.sioc.ac.cn/handle/331003/19045.[241] Li, Yuwen, Wei, Guo, Yu, Biao. Aryl C-glycosylation of phenols with glycosyl trifluoroacetimidates. CARBOHYDRATE RESEARCH[J]. 2006, 第 3 作者 通讯作者 341(16): 2717-2722, http://dx.doi.org/10.1016/j.carres.2006.08.022.[242] 李玉文, 魏国, 俞飚. Aryl C-glycosylation of phenols with glycosyl trifluoroacetimidates.. CARBOHYDR. RES.[J]. 2006, 第 3 作者341(16): 2717-2722, http://ir.sioc.ac.cn/handle/331003/19043.[243] Li, Ming, Yu, Biao. Facile conversion of spirostan saponin into furostan saponin: Synthesis of methyl protodioscin and its 26-thio-analogue. ORGANIC LETTERS[J]. 2006, 第 2 作者8(13): 2679-2682, http://202.127.28.38/handle/331003/19035.[244] Peng WenJie, Han XiuWen, Yu Biao. Synthesis of C-aryl-flavonold derivatives via Suzuki-Miyaura coupling reaction. CHINESE JOURNAL OF CHEMISTRY[J]. 2006, 第 3 作者24(9): 1154-1162, http://159.226.238.44/handle/321008/98027.[245] 周映, 林峰, 陈建芳, 俞飚. Toward synthesis of the regular sequence of heparin: synthesis of two tetrasaccharide precursors acid; one pot. CARBOHYDR. RES.[J]. 2006, 第 4 作者341(10): 1619-1629, http://ir.sioc.ac.cn/handle/331003/19033.[246] Zhu, Cunsheng, Peng, Wenjie, Li, Yuwen, Han, Xiuwen, Yu, Biao. Synthesis of 3-O-(beta-D-xylopyranosyl-(1 -> 2)-beta-D-glucopyranosyl)-3 '-O-(beta-D-glucopyranosyl)tamarixetin, the putative structure of aescuflavoside A from the seeds of Aesculus chinensis. CARBOHYDRATE RESEARCH[J]. 2006, 第 5 作者 通讯作者 341(8): 1047-1051, http://159.226.238.44/handle/321008/140159.[247] Zhou, Ying, Lin, Feng, Chen, Jianfang, Yu, Biao. Toward synthesis of the regular sequence of heparin: synthesis of two tetrasaccharide precursors. CARBOHYDRATE RESEARCH[J]. 2006, 第 4 作者 通讯作者 341(10): 1619-1629, http://dx.doi.org/10.1016/j.carres.2006.02.020.[248] Zhu, Shilei, Zhang, Yichun, Li, Ming, Yu, Jia, Zhang, Lihong, Li, Yingxia, Yu, Biao. Synthesis and cytotoxicities of dioscin derivatives with decorated chacotriosyl residues. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2006, 第 11 作者16(21): 5629-5632, http://dx.doi.org/10.1016/j.bmcl.2006.08.019.[249] 史炳峰, 汤平平, Xiaoyi Hu, Jun O. Liu, 俞飚. OSW saponins: facile synthesis toward a new type of structures with potent antitumo. J. ORG. CHEM.[J]. 2005, 第 5 作者70(25): 10354-10367, http://ir.sioc.ac.cn/handle/331003/19021.[250] 张照军, 俞飚. Total synthesis of the antiallergic naphtho -α-pyrone tetraglucoside, cassiaside C^2 isolated from cassia seeds. J. ORG. CHEM.[J]. 2003, 第 2 作者68(16): 6309-6313, http://ir.sioc.ac.cn/handle/331003/18971.[251] 汪红仪, 余伯阳, 俞飚, 惠永正. 激光共聚焦显微镜比较观察甾体皂苷Trilliuo、Lc253、Lc239对培养心肌细胞内Ca^2＋i的作用. 中国天然药物[J]. 2003, 第 3 作者1(1): 41-43, http://lib.cqvip.com/Qikan/Article/Detail?id=7990445.[252] 汪红仪, 余伯阳, 俞飚, 惠永正. Comparsion of intracellular Ca~2+ patterns affected by steriod saponin trilliuo, Lc253 and Lc239 in cultured cardiomyocytes revealed by confocal microscopy. CHIN. J. NAT. MED.[J]. 2003, 第 3 作者1(1): 41-43, http://ir.sioc.ac.cn/handle/331003/18969.[253] 俞飚, 王平. Efficient synthesis of the hexasaccharide fragment of landomycin A: Using phenyl 2,3-0-Thionocarbonyl-1-thio-glycosides as 2-deoxy-β-glycoside. ORG. LETT.[J]. 2002, 第 1 作者4(11): 1919-1922, http://ir.sioc.ac.cn/handle/331003/18953.[254] 韩秀文, 刘秀梅, 俞飚, 邢国文, 惠永正, 包信和. Total assignment of NMR spectral of the synthesized mono-and diacyl derivatives of diosgenyl saponins. MAGN. RESON. CHEM.[J]. 2002, 第 3 作者40(12): 789-792, http://ir.sioc.ac.cn/handle/331003/18945.[255] 俞飚, 陶厚朝. Glycosyl trifluoroacetimidate. 2. Synthesis of dioscin and xiebai saponin I. J. ORG. CHEM.[J]. 2002, 第 1 作者67(25): 9099-9102, http://ir.sioc.ac.cn/handle/331003/18949.[256] 朱向明, 曾文彬, 俞飚, 惠永正. 皂素皂苷脂肪链中甲基绝对构型的确定. 化学学报[J]. 2001, 第 3 作者59(10): 1653-1659, http://ir.sioc.ac.cn/handle/331003/18941.[257] 唐于平, 俞飚, 胡杰, 吴弢, 惠永正. The chemical constituents from the bulbs of ornithogalum caudatum. J. CHIN. PHARMACEUT. SCI.[J]. 2001, 第 2 作者10(4): 169-172, http://ir.sioc.ac.cn/handle/331003/18943.[258] 杨尊义, 俞飚. Stereoselective synthesis of 2-S-phenyl-2-deoxy-β-glycosides using phenyl 2,3-O-Thionocarbonyl-1-thioglycoside donors via 1,2-migration and concurrent glycosidation. ORG. LETT.[J]. 2001, 第 2 作者3(3): 377-379, http://ir.sioc.ac.cn/handle/331003/18921.[259] 杨尊义, 俞飚. Stereoselective synthesis of 2-S-ethyl(phenyl)-2-thio-β-glucopyranosides via 1,2-migration and concurrent glycosidation of ehtyl(phenyl)2,3-orthoester-1-thio-α-mannopyranosides. CARBOHYDR. RES.[J]. 2001, 第 2 作者333(1): 105-114, http://ir.sioc.ac.cn/handle/331003/18925.[260] 曾文彬, 俞飚, 朱向明, 惠永正. 皂素皂苷脂肪链中甲基绝对构型的确定. 化学学报[J]. 2001, 第 2 作者59(10): 1653-1659, http://ir.sioc.ac.cn/handle/331003/18941.[261] 朱向明, 俞飚, 惠永正. 葡萄糖醛酸苷合成进展. 有机化学[J]. 2000, 第 2 作者20(2): 146-154, http://ir.sioc.ac.cn/handle/331003/18911.[262] 马兴泉, 俞飚, 惠永正, 肖东, 丁健. Synthesis of glycosides bearing the disaccharide of OSW-1 or its 1→4 linked analogue and their antitumor activities.. CARBOHYDR. RES.[J]. 2000, 第 2 作者329(3): 495-505, http://ir.sioc.ac.cn/handle/331003/18899.[263] 张剑波, 俞飚, 惠永正. 双糖链甾体皂甙的研究进展. 有机化学[J]. 2000, 第 2 作者20(5): 663-668, http://ir.sioc.ac.cn/handle/331003/18913.[264] 杨尊义, 林文彬, 俞飚. Rearrangement of sugar 1,2-orthoester to glycosidec product: a mechanistic implication. CARBOHYDR. RES.[J]. 2000, 第 3 作者329(4): 879-884, http://ir.sioc.ac.cn/handle/331003/18915.[265] 于海, 俞飚, 吴向阳, 惠永正, 韩秀文. Synthesis of a group of diosgenyl saponins with a combined use of glycosyl trichloroacetimidate and thioglycoside. J. CHEM. SOC.-PERKIN TRANS. 1[J]. 2000, 第 2 作者1445-1453, http://ir.sioc.ac.cn/handle/331003/18905.[266] 朱向明, 俞飚, 惠永正. Di-O-benzoyl-α-D-xylopyranoside and its X-ray structure.. CHIN. J. CHEM.[J]. 2000, 第 2 作者18(1): 72-75, http://ir.sioc.ac.cn/handle/331003/18909.[267] 于海, 韩秀文, 刘秀梅, 俞飚, 惠永正, 包信和. NMR Studies on synthesized diosgenyl saponins. MAGN. RESON. CHEM.[J]. 2000, 第 4 作者38(8): 704-706, http://ir.sioc.ac.cn/handle/331003/18907.[268] 刘美正, 俞飚, 吴向阳, 惠永正, 冯国培. Synthesis of 25(R)-ruscogenin-1-yl-β-D-xylopyranosyl-(1→3)-β-Dglucopyranosyl-(1→2)-β-D-fucopyranoside.. CARBOHYDR. RES.[J]. 2000, 第 2 作者329(4): 745-754, http://ir.sioc.ac.cn/handle/331003/18917.[269] 俞飚, 杨尊义. A novel and expeditious approach to the stereoselective synthesis of 2-S-ethyl(phenyl)-2-deoxy-β-glycosides, ready precursors to 2-Deoxy-β-glycosides.. TETRAHEDRON LETT.[J]. 2000, 第 1 作者41(16): 2961-2964, http://ir.sioc.ac.cn/handle/331003/18901.[270] 韩秀文, 于海, X.M. Liu, X. Bao, 俞飚, 李川, 惠永正. Complete ^1H and ^13C NMR assignments of diosgenyl saponins. MAGN. RESON. CHEM.[J]. 1999, 第 5 作者37(2): 140-144, http://ir.sioc.ac.cn/handle/331003/18881.[271] 卢寿福, 鸥阳琴琴, 郭忠武, 俞飚, 惠永正. Synthesis of propyl O-(α-L-rhamnopyranosyl)-(1→ 3)-2,4- di-O-(2s-methylbutyryl)-α-L-rhamnopyranosyl-(1→ 2)-(3-O- acetyl-β-D-glucopyranosyl)-(1→2)-β-D-fucopyranoside, the tetrasaccharide moiety of Tricolorin A. CHIN. J. CHEM.[J]. 1998, 第 4 作者16(1): 0078-0089, http://ir.sioc.ac.cn/handle/331003/18865.[272] 刘美正, 俞飚, 惠永正. First total synthesis of 25(R)-ruscogenin-1-yl β -D- xylopyranosyl-(1→3)-β-Dglucopyranosyl-(1→)-β- Dfucopyranoside, an ophiopogonis saponin from the tuber of liriope muscari (Decne.). TETRAHEDRON LETT.[J]. 1998, 第 2 作者39: 0415-0418, http://ir.sioc.ac.cn/handle/331003/18875.[273] 卢寿福, 欧阳琴琴, 郭忠武, 俞飚, 惠永正. An efficient one-step methyl esterificaiton of carboxylic acid and deacetylation of alcohol under BF3.OEt2-MeOH. CHIN. CHEM. LETT.[J]. 1997, 第 4 作者8(10): 0843-0844, http://ir.sioc.ac.cn/handle/331003/18855.[274] 卢寿福, 欧阳琴琴, 郭忠武, 俞飚, 惠永正. First total synthesis of tricolorin A. ANGEW. CHEM.-INT. EDIT.[J]. 1997, 第 4 作者36(21): 2344-2346, http://ir.sioc.ac.cn/handle/331003/18853.[275] 俞飚, 惠永正. Supramolecular assemblies from single-chainhydrocarbon fluorocarbon hydrid bolaamphiphiles. CHIN. J. CHEM.[J]. 1996, 第 1 作者14(2): 0171-0179, http://ir.sioc.ac.cn/handle/331003/18849.[276] 俞飚. 双端头基碳氢碳氟杂化单链兼亲分子聚集体的研究. 1995, 第 1 作者http://ir.sioc.ac.cn/handle/331003/6565.[277] 俞飚, 惠永正. Stereospecific synthesis of α-D-fructofuranosides: synthesis of the oligo-fructan diastereoisomers. CHIN. CHEM. LETT.[J]. 1993, 第 1 作者4(4): 285-286, http://ir.sioc.ac.cn/handle/331003/18837.[278] Shichao Huang, Xin Cao, Yue zhou, Fuchun Shi, Shunmei Xin, Shufang He, Yuqian An, Longfei Gao, Yongfeng Yang, Biao Yu, Gang Pei. An analogue derived from phenylpropanoids ameliorates Alzheimer’s disease-like pathology and protects mitochondrial function. NEUROBIOLOGY OF AGING. 第 10 作者http://dx.doi.org/10.1016/j.neurobiolaging.2019.05.002.
科研活动
科研项目
（ 1 ） 复杂核苷类抗生素ampurimycin及miharamycin的全合成研究, 参与, 国家级, 2014-01--2017-12（ 2 ） 糖基转移酶抑制剂衣霉素(Tunicamycin)的全合成和多样性合成研究, 主持, 国家级, 2014-01--2017-12（ 3 ） 复杂糖缀合物的合成及高效糖苷化方法的研究, 主持, 国家级, 2015-01--2019-12（ 4 ） 天然产物的化学生物学, 主持, 国家级, 2017-01--2022-12（ 5 ） 复杂糖缀物[6-deoxy-L-Altp]n和amipurimycin 1的鉴定，合成和动力学研究, 主持, 国家级, 2016-01--2018-12（ 6 ） 蛋白质糖基化的化学标记与功能调控, 参与, 国家级, 2018-05--2023-04（ 7 ） 针对蛋白质糖基化的特异化学探针, 主持, 国家级, 2018-05--2023-04（ 8 ） 聚糖和糖缀合物的程式化合成和多功能解析, 主持, 部委级, 2019-09--2024-09（ 9 ） 新型抗生素Amycolamicin的全合成和构效关系研究, 主持, 国家级, 2019-01--2022-12（ 10 ） 破译磷酸乙醇胺转移酶MCR-1（一种粘菌素抗性蛋白）的作用机制及开发过渡态抑制剂, 主持, 国家级, 2019-01--2022-12（ 11 ） 深海动植物药物先导化合物的规模化全合成与优化, 主持, 国家级, 2018-08--2021-12（ 12 ） 重要复杂天然产物的高效全合成, 主持, 部委级, 2018-06--2020-12
参与会议
（1） 大会主席，第24届国际杂环化学会议，2013-09，俞飚
（2） 大会主席，第三届亚洲糖化学会议，2011-10，俞飚
（2） 大会主席，第三届亚洲糖化学会议，2011-10，俞飚
指导学生
已指导学生
王一兵 博士研究生 070303-有机化学
陈友喜 博士研究生 070303-有机化学
李瑶 博士研究生 070303-有机化学
曹文杰 博士研究生 070303-有机化学
许伟长 博士研究生 070303-有机化学
杨飞 博士研究生 070303-有机化学
杨晓瑜 博士研究生 070303-有机化学
马玉勇 博士研究生 070303-有机化学
徐鹏 博士研究生 070303-有机化学
张夏衡 博士研究生 070303-有机化学
朱玉根 博士研究生 070303-有机化学
马君君 硕士研究生 085238-生物工程
代元伟 博士研究生 070303-有机化学
现指导学生
唐宇 博士研究生 070303-有机化学
邵文博 博士研究生 070303-有机化学
刘超 硕士研究生 070303-有机化学
沈铮男 硕士研究生 070303-有机化学
沈大成 硕士研究生 070303-有机化学
朱大鹏 博士研究生 070303-有机化学
陈小平 博士研究生 070303-有机化学
郭政 硕士研究生 070303-有机化学
尹雪健 硕士研究生 070303-有机化学
张良忠 硕士研究生 070303-有机化学
付纪强 硕士研究生 070303-有机化学
王生阳 博士研究生 070303-有机化学
张浩亮 博士研究生 070303-有机化学
沈仁增 博士研究生 070303-有机化学
曾长根 博士研究生 070303-有机化学