基本信息
俞飚  男  博导  中国科学院上海有机化学研究所
电子邮件: byu@mail.sioc.ac.cn
通信地址: 上海市徐汇区零陵路345号1-306室
邮政编码: 200032

研究领域

具有重要生理活性的复杂寡糖、糖缀合物及其它天然产物的全合成、合成方法学和化学生物学。

招生信息

   
招生专业
070303-有机化学
招生方向
生命有机化学,糖化学

教育背景

1992-09--1995-07 中科院上海有机所 博士
1989-09--1992-07 中科院上海有机所 硕士
1985-09--1989-07 北京大学技术物理系 学士

工作经历

   
工作简历
1999-12--今 中科院上海有机所 研究员
1997-09--1999-11 中科院上海有机所 副研究员
1996-09--1997-08 中科院上海有机所 助理研究员
1995-09--1996-08 美国纽约大学化学系 博士后
社会兼职
2013-09--今 上海科技大学,教授
2010-09--今 上海高校E-化学生物学研究院,特聘研究员
2009-09--今 华东理工大学,特聘讲座教授
2004-09--今 中国科学技术大学,博师生导师

教授课程

天然产物合成的战略与战术
化学小分子全合成与化学生物学
现代有机合成与设计

专利与奖励

   
奖励信息
(1) 张树政糖科学杰出成就奖, 一等奖, 其他, 2019
(2) Fellow of the Royal Society of Chemistry, 其他, 2016
(3) “万人计划”第一批科技创新领军人才, , 部委级, 2014
(4) 中科院朱李月华优秀教师奖, 部委级, 2014
(5) 上海市首届青年科技杰出贡献奖, 一等奖, 省级, 2013
(6) 创新人才推进计划中青年科技创新领军人才, 部委级, 2013
(7) 上海市自然科学牡丹奖, 一等奖, 省级, 2012
(8) 国家自然科学奖, 二等奖, 国家级, 2010
(9) 上海市自然科学奖, 二等奖, 省级, 2006
专利成果
( 1 ) 一种原人参三醇类人参皂苷的制备方法, 发明, 2012, 第 1 作者, 专利号: 201210090482.5
( 2 ) 糖基聚醚、制备方法及用途, 发明, 2012, 第 1 作者, 专利号: CN101792524B
( 3 ) 虎眼万年青OSW-1 皂甙的无A、B 环的双环类似物,合成方法 和用途, 发明, 2010, 第 1 作者, 专利号: CN101089008B
( 4 ) 3-芳基-8-羟基色原酮-7-O-alpha-D-呋喃阿拉伯糖苷化 合物及其合成方法和用途, 发明, 2011, 第 1 作者, 专利号: 200810035318.8
( 5 ) 一种糖胺聚糖类化合物N,O-同时硫酸化的方法及其反应中间体, 发明, 2015, 第 1 作者, 专利号: ZL201510023345.3
( 6 ) 用于防治神经退行性疾病的新化合物及其应用, 发明, 2018, 第 2 作者, 专利号: 201810118796.9
( 7 ) 神经退行性疾病的治疗药物及其应用, 发明, 2018, 第 2 作者, 专利号: 201810616404.1
( 8 ) 一种视黄酸类化合物、其制备方法、中间体及应用, 发明, 2016, 第 2 作者, 专利号: 201610310944.8
( 9 ) 果同尼皂苷F及其衍生物的中间体, 制备方法和用途及果同尼皂苷F衍生物, 发明, 2014, 第 1 作者, 专利号: ZL201410045279.5

出版信息

   
发表论文
[1] Wang, Ziqiang, Wei, Bingcheng, Mu, Tong, Xu, Peng, Yu, Biao. Facile Synthesis of Saikosaponins. MOLECULES[J]. 2021, 26(7): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000638726800001.
[2] Yu, Biao, Wang, Shengyang. Solving the Structural Puzzles of Amipurimycin and Miharamycins Enabled by Stereodivergent Total Synthesis. CHEMICAL RECORD[J]. 2021, 21(11): 3015-3028, http://dx.doi.org/10.1002/tcr.202100057.
[3] Fu, Jiqiang, Xu, Peng, Yu, Biao. Total Synthesis of Nucleoside Antibiotics Amicetin, Plicacetin, and Cytosaminomycin A-D. CHINESE JOURNAL OF CHEMISTRY[J]. 2021, 39(10): 2679-2684, http://dx.doi.org/10.1002/cjoc.202100284.
[4] Mu, Tong, Xu, Peng, Yu, Biao. Facile Synthesis of Oleanane-type Pentacyclic Triterpenoids Bearing Hydroxy Groups on D/E Rings. ASIAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2021, 10(7): 1752-1755, http://dx.doi.org/10.1002/ajoc.202100316.
[5] Wang, Yingjie, Yu, Biao. Total Syntheses of Aturanosides A and B. ORGANIC LETTERS[J]. 2021, 23(17): 6680-6684, http://dx.doi.org/10.1021/acs.orglett.1c02244.
[6] Cui, Zhaomeng, Liu, Yang, Wan, Wei, Xu, Yuyan, Hu, Yehui, Ding, Meng, Dou, Xin, Wang, Ruina, Li, Hailing, Meng, Yongmei, Li, Wei, Jiang, Wei, Li, Zengxia, Li, Yiming, Tan, Minjia, Ma, Dengke K, Ding, Yu, Liu, Jun O, Luo, Cheng, Yu, Biao, Tang, Qiqun, Dang, Yongjun. Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes. PROTEIN & CELLnull. 2021, 12(6): 493-501, http://dx.doi.org/10.1007/s13238-020-00717-7.
[7] YanHua Liu, YuNong Xia, Tayyab Gulzar, Bingcheng Wei, Haotian Li, Dapeng Zhu, Zhifei Hu, Peng Xu, Biao Yu. Facile access to C-glycosyl amino acids and peptides via Ni-catalyzed reductive hydroglycosylation of alkynes. NATURE COMMUNICATIONS[J]. 2021, 12(1): http://dx.doi.org/10.1038/s41467-021-25127-z.
[8] Chen, Jianpeng, Tang, Yu, Yu, Biao. A Mild Glycosylation Protocol with Glycosyl 1-Methylimidazole-2-carboxylates as Donors. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2021, 2021(30): 4333-4344, http://dx.doi.org/10.1002/ejoc.202100677.
[9] Zhao, Yachen, Wang, Shengyang, Yu, Biao. Dimerization of aldosuloses and aldonolactones into branched higher carbon sugars. CHEMICAL COMMUNICATIONS[J]. 2020, 56(13): 2020-2022, https://www.webofscience.com/wos/woscc/full-record/WOS:000514651200020.
[10] Zhang, Liangzhong, Xu, Peng, Liu, Benzhang, Yu, Biao. Chemical Synthesis of Fucosylated Chondroitin Sulfate Oligosaccharides. JOURNAL OF ORGANIC CHEMISTRY[J]. 2020, 85(24): 15908-15919, https://www.webofscience.com/wos/woscc/full-record/WOS:000609003400014.
[11] Wang, Fei, Zhang, WenHe, Zhao, Juan, Kang, WenJia, Wang, Shengyang, Yu, Biao, Pan, HaiXue, Tang, GongLi. Characterization of Miharamycin Biosynthesis Reveals a Hybrid NRPS-PKS to Synthesize High-Carbon Sugar from a Complex Nucleoside. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2020, 142(13): 5996-6000, https://www.webofscience.com/wos/woscc/full-record/WOS:000526393700017.
[12] Shao, Xiaofei, Wang, Xiaobo, Zhu, Kaidi, Dang, Yongjun, Yu, Biao. Synthesis of Sea Cucumber Saponins with Antitumor Activities. JOURNAL OF ORGANIC CHEMISTRY[J]. 2020, 85(19): 12080-12096, https://www.webofscience.com/wos/woscc/full-record/WOS:000577156600008.
[13] Qian Zhu, Zhengnan Shen, Fabrizio Chiodo, Simone Nicolardi, Antonio Molinaro, Alba Silipo, Biao Yu. Chemical synthesis of glycans up to a 128-mer relevant to the O-antigen of Bacteroides vulgatus. NATURE COMMUNICATIONS[J]. 2020, 11(1): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000607072900008.
[14] Li, Wei, Yu, Biao, Baker, DC. Temporary ether protecting groups at the anomeric center in complex carbohydrate synthesis. ADVANCES IN CARBOHYDRATE CHEMISTRY AND BIOCHEMISTRY, VOL 77null. 2020, 77: 1-69, https://www.webofscience.com/wos/woscc/full-record/WOS:000610756800002.
[15] Yin, Xuejian, Li, Wei, Yu, Biao. Synthesis of Pashinintide A, a Natural Cyclic Hexapeptide Supposedly Capable of Forming a Complex with Sucrose. ASIAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2020, 9(1): 53-56, https://www.webofscience.com/wos/woscc/full-record/WOS:000507988300006.
[16] Biao Yu. Coinage Metal (Bisfluorosulfonyl)imide Complexes: Preparation, Characterization, and Catalytic Applications Yu Tang. Asian Journal of Inorganic Chemistry. 2020, [17] Mu, Tong, Wei, Bingcheng, Zhu, Dapeng, Yu, Biao. Site-selective C-H hydroxylation of pentacyclic triterpenoids directed by transient chiral pyridine-imino groups. NATURE COMMUNICATIONS[J]. 2020, 11(1): http://dx.doi.org/10.1038/s41467-020-18138-9.
[18] Wang, Shengyang, Zhang, Qingju, Zhao, Yachen, Sun, Jiansong, Kang, Wenjia, Wang, Fei, Pan, Haixue, Tang, Gongli, Yu, Biao. The Miharamycins and Amipurimycin: their Structural Revision and the Total Synthesis of the Latter. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(31): 10558-10562, http://dx.doi.org/10.1002/anie.201905723.
[19] Hu, Zhifei, Tang, Yu, Yu, Biao. Glycosylation with 3,5-Dimethyl-4-(2 '-phenylethynylphenyl)phenyl (EPP) Glycosides via a Dearomative Activation Mechanism. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2019, 141(12): 4806-4810, https://www.webofscience.com/wos/woscc/full-record/WOS:000462950800005.
[20] Ehianeta, Teddy Stephen, Shen, Dacheng, Xu, Peng, Yu, Biao. Synthesis of spirostanol saponins via gold(I)-catalyzed glycosylation in the presence of Ga(OTf)(3), In(OTf)(3), or HOTf. CHINESE JOURNAL OF CHEMISTRY[J]. 2019, 37(8): 827-833, https://www.webofscience.com/wos/woscc/full-record/WOS:000475948400012.
[21] Sun, Lijun, Wang, Ruina, Wang, Xiaobo, Dang, Yongjun, Li, Wei, Yu, Biao. Synthesis and antiproliferative activities of OSW-1 analogues bearing 2-acylamino-xylose residues. ORGANIC CHEMISTRY FRONTIERS[J]. 2019, 6(14): 2385-2391, [22] Hu, Zhifei, Silipo, Alba, Li, Wei, Molinaro, Antonio, Yu, Biao. Synthesis of Forsythenethoside A, a Neuroprotective Macrocyclic Phenylethanoid Glycoside, and NMR Analysis of Conformers. JOURNAL OF ORGANIC CHEMISTRY[J]. 2019, 84(21): 13733-13743, [23] Xiao, Guozhi, Shao, Xiaofei, Zhu, Dapeng, Yu, Biao. Chemical synthesis of marine saponins. NATURAL PRODUCT REPORTSnull. 2019, 36(5): 769-787, [24] Yu, Biao. Gold(I)-Catalyzed Glycosylation with Glycosyl o-Alkynylbenzoates as Donors. ACCOUNTS OF CHEMICAL RESEARCHnull. 2018, 51(2): 507-516, https://www.webofscience.com/wos/woscc/full-record/WOS:000426014500032.
[25] Junwei Chen, Xin Cao, Quanlin An, Yao Zhang, Ke Li, Wenting Yao, Fuchun Shi, Yanfang Pan, Qiong Jia, Wenwen Zhou, Fang Yang, Fuxiang Wei, Ning Wang, Biao Yu. Inhibition of cancer stem cell like cells by a synthetic retinoid. NATURE COMMUNICATIONS[J]. 2018, 9(1): https://doaj.org/article/b6f1e3d96dae479b89a8288224c3c159.
[26] Biao Yu. Total Synthesis of the Proposed Structures and Diastereoisomers.. Angew. Chem. Int. Ed.. 2018, [27] Zhu, Dapeng, Yu, Biao. Synthesis of the Diverse Glycosides in Traditional Chinese Medicine. CHINESE JOURNAL OF CHEMISTRY[J]. 2018, 36(8): 681-691, http://lib.cqvip.com/Qikan/Article/Detail?id=676094103.
[28] Li, Wei, Silipo, Alba, Gersby, Lotte Bettina Andersen, Newman, MariAnne, Molinaro, Antonio, Yu, Biao. Synthesis of Bradyrhizose Oligosaccharides Relevant to the Bradyrhizobium O-Antigen. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2017, 56(8): 2092-2096, https://www.webofscience.com/wos/woscc/full-record/WOS:000397323300021.
[29] Biao Yu. Synthesis of beta-(1-->2)-Linked 6-Deoxy-l-altropyranose Oligosaccharides via Gold(I)-Catalyzed Glycosylation of an ortho-Hexynylbenzoate Donor. J Org Chem. 2017, [30] Shen, Renzeng, Cao, Xin, Laval, Stephane, Sun, Jiansong, Yu, Biao. Synthesis of Ocotillol-Type Ginsenosides. JOURNAL OF ORGANIC CHEMISTRY[J]. 2016, 81(21): 10279-10294, https://www.webofscience.com/wos/woscc/full-record/WOS:000387303300019.
[31] Xu, Peng, Laval, Stephane, Guo, Zheng, Yu, Biao. Microwave-assisted simultaneous O,N-sulfonation in the synthesis of heparin-like oligosaccharides. ORGANIC CHEMISTRY FRONTIERS[J]. 2016, 3(1): 103-109, https://www.webofscience.com/wos/woscc/full-record/WOS:000366864700017.
[32] Zhu, Yugen, Shen, Zhengnan, Li, Wei, Yu, Biao. Stereoselective synthesis of beta-rhamnopyranosides via gold(I)-catalyzed glycosylation with 2-alkynyl-4-nitro-benzoate donors. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2016, 14(5): 1536-1539, https://www.webofscience.com/wos/woscc/full-record/WOS:000369600000003.
[33] Chen, Xiaoping, Wang, Qiaoling, Yu, Biao. Gold(I)-catalyzed C-glycosylation of glycosyl ortho-alkynylbenzoates: the role of the moisture sequestered by molecular sieves. CHEMICAL COMMUNICATIONS[J]. 2016, 52(82): 12183-12186, https://www.webofscience.com/wos/woscc/full-record/WOS:000385165800012.
[34] Zhu, Dapeng, Yu, Biao. Total Synthesis of Linckosides A and B, the Representative Starfish Polyhydroxysteroid Glycosides with Neuritogenic Activities. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2015, 137(48): 15098-15101, https://www.webofscience.com/wos/woscc/full-record/WOS:000366339900010.
[35] Zhang, Xiaheng, Zhou, Yu, Zuo, Jianping, Yu, Biao. Total synthesis of periploside A, a unique pregnane hexasaccharide with potent immunosuppressive effects. NATURE COMMUNICATIONS[J]. 2015, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000348702400003.
[36] Li, Jiakun, Yu, Biao. A Modular Approach to the Total Synthesis of Tunicamycins. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2015, 54(22): 6618-6621, https://www.webofscience.com/wos/woscc/full-record/WOS:000355229800041.
[37] Nie Shenyou, Li Wei, Yu Biao. Total Synthesis of Nucleoside Antibiotic A201A. J. Am. Chem. Soc.[J]. 2014, 136(11): 4157-4160, http://ir.sioc.ac.cn/handle/331003/38938.
[38] ZHANG SHUYONG, 马玉勇, LI JING, 马君君, 俞飚, 谢欣. Molecular matchmaking between the popular weight-loss herb Hoodia gordonii and GPR119, a potential drug target for metabolic disorder AMERICA. Proc. Natl. Acad. Sci. U. S. A.[J]. 2014, 111(40): 14571-14576, http://ir.sioc.ac.cn/handle/331003/38956.
[39] Yu Jun, Sun Jiansong, Niu Yiming, Li Rongyao, Liao Jinxi, Zhang Fuyi, Yu Biao. Synthetic access toward the diverse ginsenosides. Chem. Sci.[J]. 2013, 4(10): 3899-3905, http://www.irgrid.ac.cn/handle/1471x/868774.
[40] Tang Yu, Li Jiakun, Zhu Yugen, Li Yao, Yu Biao. Mechanistic Insights into the Gold(I)-Catalyzed Activation of Glycosyl ortho-Alkynylbenzoates for Glycosidation. J. Am. Chem. Soc.[J]. 2013, 135(49): 18396-18405, http://www.irgrid.ac.cn/handle/1471x/870615.
[41] Yu, Biao, Sun, Jiansong, Yang, Xiaoyu. Assembly of Naturally Occurring Glycosides, Evolved Tactics, and Glycosylation Methods. ACCOUNTS OF CHEMICAL RESEARCHnull. 2012, 45(8): 1227-1236, http://www.irgrid.ac.cn/handle/1471x/681941.
[42] Qingju Zhang, Jiansong Sun, Yugen Zhu, Fuyi Zhang, Biao Yu. An Efficient Approach to the Synthesis of Nucleosides: Gold(I)-Catalyzed N-Glycosylation of Pyrimidines and Purines with Glycosyl ortho-Alkynyl Benzoates†. Angew. Chem.-Int. Edit.[J]. 2011, 50(21): 4933-4936, http://www.irgrid.ac.cn/handle/1471x/587864.
[43] YANG XIAOYU, Fu Boqiao, Yu Biao. Total Synthesis of Landomycin A, a Potent Antitumor Angucycline Antibiotic. J. Am. Chem. Soc.[J]. 2011, 133(32): 12433-12435, http://www.irgrid.ac.cn/handle/1471x/587865.

科研活动

   
科研项目
( 1 ) 复杂核苷类抗生素ampurimycin及miharamycin的全合成研究, 参与, 国家级, 2014-01--2017-12
( 2 ) 糖基转移酶抑制剂衣霉素(Tunicamycin)的全合成和多样性合成研究, 主持, 国家级, 2014-01--2017-12
( 3 ) 复杂糖缀合物的合成及高效糖苷化方法的研究, 主持, 国家级, 2015-01--2019-12
( 4 ) 天然产物的化学生物学, 主持, 国家级, 2017-01--2022-12
( 5 ) 复杂糖缀物[6-deoxy-L-Altp]n和amipurimycin 1的鉴定,合成和动力学研究, 主持, 国家级, 2016-01--2018-12
( 6 ) 蛋白质糖基化的化学标记与功能调控, 参与, 国家级, 2018-05--2023-04
( 7 ) 针对蛋白质糖基化的特异化学探针, 主持, 国家级, 2018-05--2023-04
( 8 ) 聚糖和糖缀合物的程式化合成和多功能解析, 主持, 部委级, 2019-09--2024-09
( 9 ) 新型抗生素Amycolamicin的全合成和构效关系研究, 主持, 国家级, 2019-01--2022-12
( 10 ) 破译磷酸乙醇胺转移酶MCR-1(一种粘菌素抗性蛋白)的作用机制及开发过渡态抑制剂, 主持, 国家级, 2019-01--2022-12
( 11 ) 深海动植物药物先导化合物的规模化全合成与优化, 主持, 国家级, 2018-08--2021-12
( 12 ) 重要复杂天然产物的高效全合成, 主持, 部委级, 2018-06--2020-12
参与会议
(1) 大会主席,第24届国际杂环化学会议,2013-09,俞飚
(2) 大会主席,第三届亚洲糖化学会议,2011-10,俞飚

指导学生

已指导学生

王一兵  博士研究生  070303-有机化学  

陈友喜  博士研究生  070303-有机化学  

李瑶  博士研究生  070303-有机化学  

曹文杰  博士研究生  070303-有机化学  

许伟长  博士研究生  070303-有机化学  

杨飞  博士研究生  070303-有机化学  

杨晓瑜  博士研究生  070303-有机化学  

马玉勇  博士研究生  070303-有机化学  

徐鹏  博士研究生  070303-有机化学  

张夏衡  博士研究生  070303-有机化学  

朱玉根  博士研究生  070303-有机化学  

马君君  硕士研究生  085238-生物工程  

代元伟  博士研究生  070303-有机化学  

现指导学生

唐宇  博士研究生  070303-有机化学  

邵文博  博士研究生  070303-有机化学  

刘超  硕士研究生  070303-有机化学  

沈铮男  硕士研究生  070303-有机化学  

沈大成  硕士研究生  070303-有机化学  

朱大鹏  博士研究生  070303-有机化学  

陈小平  博士研究生  070303-有机化学  

郭政  硕士研究生  070303-有机化学  

尹雪健  硕士研究生  070303-有机化学  

张良忠  硕士研究生  070303-有机化学  

付纪强  硕士研究生  070303-有机化学  

王生阳  博士研究生  070303-有机化学  

张浩亮  博士研究生  070303-有机化学  

沈仁增  博士研究生  070303-有机化学  

曾长根  博士研究生  070303-有机化学