主要从事昆虫真菌分子遗传及真菌—昆虫互作机理研究。以金龟子绿僵菌、蝗绿僵菌、蛹虫草及冬虫夏草等为对象，通过表观遗传、反向遗传及化学生物学等手段，研究真菌效应蛋白基因、毒力基因相关基因的作用与功能，以及虫生真菌次级代谢产物多样性、合成机理与生物学功能; 同时研究丝状真菌退化机理研究：细胞自噬、线粒体功能、氧化胁迫与真菌退化的关联性及机理研究。

   

071010-生物化学与分子生物学
071002-动物学
071005-微生物学

真菌分子生物学;昆虫病理学

1998-09--2001-07   中国农业大学   博士
1993-09--1996-07   安徽农业大学   硕士
1989-09--1993-07   安徽农业大学   学士

   

2020-05~现在, 中国科学院分子植物科学卓越创新中心/植物生理生态研究所, 研究员
2007-01~2020-04,中国科学院上海生命科学研究院植物生理生态研究所, 研究员
2004-01~2006-12,University of Maryland, 博士后
2001-08~2003-12,University of Swansea, 博士后
1996-08~1998-06,安徽农业大学, 讲师

2017-08-12-今,中国昆虫学会, 副理事长
2017-03-11-2019-12-31,上海昆虫学会, 理事长
2014-07-15-2017-08-12,中国菌物学会, 理事长
2014-07-01-今,上海科技大学, 兼职教授

现代昆虫学

   

（1） 上海市优秀学术带头人, , 省级, 2018
（2） 亚洲杰出真菌学家奖, 其他, 2017
（3） 中国菌物学会“戴芳澜杰出成就奖”, 其他, 2017
（4） 中国科学院“朱李月华”优秀教师奖, 部委级, 2015
（5） 明治生命科学奖优秀奖, 其他, 2013
（6） 国家科技进步奖, 二等奖, 国家级, 2009

（ 1 ） 卵孢霉素的生物合成基因簇及其应用, 发明, 2015, 第 1 作者, 专利号: 2015100703622
（ 2 ） 蛹虫草代谢产物—虫草素的合成基因簇的鉴定和应用, 发明, 2014, 第 1 作者, 专利号: 201410425608.9
（ 3 ） 蝎毒素基因转化杀虫真菌工程菌株及应用, 发明, 2008, 第 1 作者, 专利号: ZL200880016082.1
（ 4 ） 绿僵菌破坏素合成相关基因及应用, 发明, 2012, 第 1 作者, 专利号: 2012004127.1

   

[1] Li, Bing, Song, Shuangxiu, Wei, Xuefei, Tang, Guirong, Wang, Chengshu. Activation of microlipophagy during early infection of insect hosts by Metarhizium robertsii. AUTOPHAGY[J]. 2022, 18(3): 608-623, [2] Song Hong, Yanlei Sun, Dapeng Sun, Chengshu Wang. Microbiome assembly on Drosophila body surfaces benefits the flies to combat fungal infections. iScience[J]. 2022, 25(6): 104408-, [3] Lijuan Mei, Xuewen Wang, Ying Yin, Guirong Tang, Chengshu Wang. Conservative production of galactosaminogalactan in Metarhizium is responsible for appressorium mucilage production and topical infection of insect hosts. PLOS PATHOGENS[J]. 2021, 17(6): e1009656-, http://dx.doi.org/10.1371/journal.ppat.1009656.
[4] Shang, Junmei, Shang, Yanfang, Tang, Guirong, Wang, Chengshu. Identification of a key G-protein coupled receptor in mediating appressorium formation and fungal virulence against insects. SCIENCE CHINA-LIFE SCIENCES[J]. 2021, 64(3): 466-477, http://dx.doi.org/10.1007/s11427-020-1763-1.
[5] Li, Shiqin, Yi, Wenjuan, Chen, Siyi, Wang, Chengshu. Empirical Support for the Pattern of Competitive Exclusion between Insect Parasitic Fungi. JOURNAL OF FUNGI[J]. 2021, 7(5): http://dx.doi.org/10.3390/jof7050385.
[6] Xiao, Guohua, Tang, Guirong, Wang, Chengshu. Congruence Amidst Discordance between Sequence and Protein-Content Based Phylogenies of Fungi. JOURNAL OF FUNGI[J]. 2020, 6(3): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559059/.
[7] Mei, Lijuan, Chen, Mingjun, Shang, Yanfang, Tang, Guirong, Tao, Ye, Zeng, Liang, Huang, Bo, Li, Zengzhi, Zhan, Shuai, Wang, Chengshu. Population genomics and evolution of a fungal pathogen after releasing exotic strains to control insect pests for 20 years. ISME JOURNAL[J]. 2020, 14(6): 1422-1434, https://www.webofscience.com/wos/woscc/full-record/WOS:000517047500001.
[8] Antian Huang, Mengting Lu, Erjun Ling, Ping Li, Chengshu Wang. A M35 family metalloprotease is required for fungal virulence against insects by inactivating host prophenoloxidases and beyond. VIRULENCE[J]. 2020, 11(1): 222-237, https://doaj.org/article/871c927f28fd40fe90d4e688bf80b7d1.
[9] Tang, Guirong, Shang, Yanfang, Li, Shiqing, Wang, Chengshu. MrHex1 is Required for Woronin Body Formation, Fungal Development and Virulence in Metarhizium robertsii. JOURNAL OF FUNGI[J]. 2020, 6(3): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000581365400001.
[10] Ying Yin, Bo Chen, Shuangxiu Song, Bing Li, Xiuqing Yang, Chengshu Wang. Production of Diverse Beauveriolide Analogs in Closely Related Fungi: a Rare Case of Fungal Chemodiversity. MSPHERE[J]. 2020, 5(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000579365500065.
[11] Luo, Feifei, Hong, Song, Chen, Bo, Yin, Ying, Tang, Guirong, Hu, Fenglin, Zhang, Huizhan, Wang, Chengshu. Unveiling of Swainsonine Biosynthesis via a Multibranched Pathway in Fungi. ACS CHEMICAL BIOLOGY[J]. 2020, 15(9): 2476-2484, https://www.webofscience.com/wos/woscc/full-record/WOS:000574920900016.
[12] Guirong Tang, Yanfang Shang, Shiqing Li, Chengshu Wang. MrHex1 is Required for Woronin Body Formation, Fungal Development and Virulence in Metarhizium robertsii. Journal of Fungi[J]. 2020, 6(172): https://doaj.org/article/771ef7455473437d9d48aaa1d078d259.
[13] Wang Chengshu. roduction of diverse beauveriolide analogs in closely related fungi: a rare case of fungal chemodiversity. mSphere. 2020, [14] Chen, Bo, Sun, Yanlei, Luo, Feifei, Wang, Chengshu. Bioactive Metabolites and Potential Mycotoxins Produced by Cordyceps Fungi: A Review of Safety. TOXINSnull. 2020, 12(6): https://www.webofscience.com/wos/woscc/full-record/WOS:000551188000072.
[15] Bo Chen, Yanlei Sun, Feifei Luo, Chengshu Wang. Bioactive Metabolites and Potential Mycotoxins Produced by Cordyceps Fungi: A Review of Safety. Toxins[J]. 2020, 12(410): https://doaj.org/article/c71441903d094047b6dc75557594029a.
[16] Huang, Wei, Hong, Song, Tang, Guirong, Lu, Yuzhen, Wang, Chengshu. Unveiling the function and regulation control of the DUF3129 family proteins in fungal infection of hosts. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES[J]. 2019, 374(1767): https://www.webofscience.com/wos/woscc/full-record/WOS:000460484100016.
[17] Xiuqing Yang, Peng Feng, Ying Yin, Kathryn Bushley, Joseph W Spatafora, Chengshu Wang. Cyclosporine Biosynthesis in Tolypocladium inflatum Benefits Fungal Adaptation to the Environment. mBio[J]. 2018, 9(5): https://doaj.org/article/635a850c3cdc48b19bd154b69f486bf0.
[18] Xiuqing Yang, Peng Feng, Ying Yin, Kathryn Bushley, Joseph W Spatafora, Chengshu Wang. Cyclosporine Biosynthesis in Tolypocladium inflatum Benefits Fungal Adaptation to the Environment. mBio[J]. 2018, 9(5): [19] Chen, Yixiong, Li, Bing, Cen, Kai, Lu, Yuzhen, Zhang, Siwei, Wang, Chengshu. Diverse effect of phosphatidylcholine biosynthetic genes on phospholipid homeostasis, cell autophagy and fungal developments in Metarhizium robertsii. ENVIRONMENTAL MICROBIOLOGY[J]. 2018, 20(1): 293-304, https://www.webofscience.com/wos/woscc/full-record/WOS:000419784100023.
[20] Cen, Kai, Li, Bing, Lu, Yuzhen, Zhang, Siwei, Wang, Chengshu. Divergent LysM effectors contribute to the virulence of Beauveria bassiana by evasion of insect immune defenses. PLOS PATHOGENS[J]. 2017, 13(9): https://doaj.org/article/c1cb69c8800c4d7996a9347ca1876a76.
[21] Zhang, Jie, Huang, Wuren, Yuan, Chuanfei, Lu, Yuzhen, Yang, Bing, Wang, ChengYuan, Zhang, Peng, Dobens, Leonard, Zou, Zhen, Wang, Chengshu, Ling, Erjun. Prophenoloxidase-Mediated Ex Vivo immunity to Delay Fungal infection after insect ecdysis. FRONTIERS IN IMMUNOLOGY[J]. 2017, 8: https://doaj.org/article/da701a1c5a884851835f9335bea9a1fa.
[22] Xia, Yongliang, Luo, Feifei, Shang, Yanfang, Chen, Peilin, Lu, Yuzhen, Wang, Chengshu. Fungal Cordycepin Biosynthesis Is Coupled with the Production of the Safeguard Molecule Pentostatin. CELL CHEMICAL BIOLOGY[J]. 2017, 24(12): 1479-+, http://dx.doi.org/10.1016/j.chembiol.2017.09.001.
[23] Wang Chengshu, Wang Sibao, Berenbaum MR. Insect Pathogenic Fungi: Genomics, Molecular Interactions, and Genetic Improvements. ANNUAL REVIEW OF ENTOMOLOGY, VOL 62null. 2017, 62: 73-90, https://www.webofscience.com/wos/woscc/full-record/WOS:000393550200006.
[24] Lu, Yuzhen, Xia, Yongliang, Luo, Feifei, Dong, Caihong, Wang, Chengshu. Functional convergence and divergence of mating-type genes fulfilling in Cordyceps militaris. FUNGAL GENETICS AND BIOLOGY[J]. 2016, 88: 35-43, http://dx.doi.org/10.1016/j.fgb.2016.01.013.
[25] Xu, YongJiang, Luo, Feifei, Li, Bing, Shang, Yanfang, Wang, Chengshu. Metabolic Conservation and Diversification of Metarhizium Species Correlate with Fungal Host-Specificity. FRONTIERS IN MICROBIOLOGY[J]. 2016, 7: https://doaj.org/article/9fc238610019470a90d189c3bba1f731.
[26] Shang, Yanfang, Xiao, Guohua, Zheng, Peng, Cen, Kai, Zhan, Shuai, Wang, Chengshu. Divergent and Convergent Evolution of Fungal Pathogenicity. GENOME BIOLOGY AND EVOLUTION[J]. 2016, 8(5): 1374-1387, https://www.webofscience.com/wos/woscc/full-record/WOS:000378633000008.
[27] Gao, Qiang, Lu, Yuzhen, Yao, Hongyan, Xu, YongJiang, Huang, Wei, Wang, Chengshu. Phospholipid homeostasis maintains cell polarity, development and virulence in metarhizium robertsii. ENVIRONMENTAL MICROBIOLOGY[J]. 2016, 18(11): 3976-3990, https://www.webofscience.com/wos/woscc/full-record/WOS:000388614800028.
[28] Wang, J B, St Leger, R J, Wang, C, Lovett, B, StLeger, RJ. Advances in Genomics of Entomopathogenic Fungi. GENETICS AND MOLECULAR BIOLOGY OF ENTOMOPATHOGENIC FUNGInull. 2016, 94: 67-105, https://www.webofscience.com/wos/woscc/full-record/WOS:000381942200004.
[29] Wang Chengshu. Fungal biosynthesis of the bibenzoquinoe oosporein to evade insect immunity. Proceedings of the National Academy of Sciences USA, 112(36): 11365-11370.. 2015, [30] Chen, Yixiong, Feng, Peng, Shang, Yanfang, Xu, YongJiang, Wang, Chengshu. Biosynthesis of non-melanin pigment by a divergent polyketide synthase in Metarhizium robertsii. FUNGAL GENETICS AND BIOLOGY[J]. 2015, 81: 142-149, http://dx.doi.org/10.1016/j.fgb.2014.10.018.
[31] Huang, Wei, Shang, Yanfang, Chen, Peilin, Cen, Kai, Wang, Chengshu. Basic Leucine Zipper (bZIP) Domain Transcription Factor MBZ1 Regulates Cell Wall Integrity, Spore Adherence, and Virulence in Metarhizium robertsii. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2015, 290(13): 8218-8231, http://dx.doi.org/10.1074/jbc.M114.630939.
[32] Peng Feng, Chengshu Wang, Yanfang Shang. Fungi That Infect Insects: Altering Host Behavior and Beyond. Public Library of Science. 2015, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201912010178019ZK.
[33] Huang, Wei, Shang, Yanfang, Chen, Peilin, Gao, Qiang, Wang, Chengshu. MrpacC regulates sporulation, insect cuticle penetration and immune evasion in Metarhizium robertsii. ENVIRONMENTAL MICROBIOLOGY[J]. 2015, 17(4): 994-1008, http://dx.doi.org/10.1111/1462-2920.12451.
[34] Hu, Xiao, Xiao, Guohua, Zheng, Peng, Shang, Yanfang, Su, Yao, Zhang, Xinyu, Liu, Xingzhong, Zhan, Shuai, St Leger, Raymond J, Wang, Chengshu. Trajectory and genomic determinants of fungal-pathogen speciation and host adaptation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2014, 111(47): 16796-16801, https://www.webofscience.com/wos/woscc/full-record/WOS:000345662700043.
[35] Li, Lin, Hu, Xiao, Xia, Yongliang, Xiao, Guohua, Zheng, Peng, Wang, Chengshu. Linkage of Oxidative Stress and Mitochondrial Dysfunctions to Spontaneous Culture Degeneration in Aspergillus nidulans. MOLECULAR & CELLULAR PROTEOMICS[J]. 2014, 13(2): 449-461, http://dx.doi.org/10.1074/mcp.M113.028480.
[36] Duan, Zhibing, Chen, Yixiong, Huang, Wei, Shang, Yanfang, Chen, Peilin, Wang, Chengshu. Linkage of autophagy to fungal development, lipid storage and virulence in Metarhizium robertsii. AUTOPHAGY[J]. 2013, 9(4): 538-549, http://dx.doi.org/10.4161/auto.23575.
[37] Gao, Qiang, Shang, Yanfang, Huang, Wei, Wang, Chengshu. Glycerol-3-Phosphate Acyltransferase Contributes to Triacylglycerol Biosynthesis, Lipid Droplet Formation, and Host Invasion in Metarhizium robertsii. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2013, 79(24): 7646-7653, http://dx.doi.org/10.1128/AEM.02905-13.
[38] Wang, Bing, Kang, Qianjin, Lu, Yuzhen, Bai, Linquan, Wang, Chengshu. Unveiling the biosynthetic puzzle of destruxins in Metarhizium species. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2012, 109(4): 1287-1292, http://dx.doi.org/10.1073/pnas.1115983109.
[39] Zheng, Peng, Xia, Yongliang, Xiao, Guohua, Xiong, Chenghui, Hu, Xiao, Zhang, Siwei, Zheng, Huajun, Huang, Yin, Zhou, Yan, Wang, Shengyue, Zhao, GuoPing, Liu, Xingzhong, St Leger, Raymond J, Wang, Chengshu. Genome sequence of the insect pathogenic fungus Cordyceps militaris, a valued traditional chinese medicine. GENOME BIOLOGY[J]. 2011, 12(11): R116-R116, http://dx.doi.org/10.1186/gb-2011-12-11-r116.

   

（ 1 ） 害虫生防真菌致病机理与遗传改造, 主持, 国家级, 2013-01--2016-12
（ 2 ） 基因组学水平的虫生真菌次级代谢演化与功能研究, 主持, 国家级, 2016-01--2020-12
（ 3 ） 昆虫病原真菌宿主识别与免疫应答的调控机制, 主持, 部委级, 2014-07--2019-07
（ 4 ） 生防微生物的寄主识别与互作机制, 主持, 国家级, 2017-01--2020-12
（ 5 ） 真菌—昆虫互作效应机理研究, 主持, 部委级, 2017-05--2019-04
（ 6 ） 真菌-昆虫互作的化学生物学研究, 主持, 省级, 2018-05--2021-04

（1）Genetic potentials of bioactive molecule productions in Cordyceps fungi   2016-10-16
（2）Co-evolution and interactions between the insects and fungi   2016-09-24
（3）Biosynthesis of bioactive molecules in the medicinal insect pathogenic fungi   2016-07-24

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