100706-药理学
100800-中药学

分子药理学
中药药理学

1994-09--2000-06   中国科学院上海药物研究所   研究生/博士
1988-09--1992-06   浙江医科大学   大学本科

   

2019-02~现在, 中国科学院上海药物研究所, 所长
2013-12~2019-02,中国科学院上海药物研究所, 副所长
2010-09~2013-12,中国科学院上海药物研究所, 所长助理
2006-07~现在, 中国科学院上海药物研究所, 博士生导师
1994-09~2000-06,中国科学院上海药物研究所, 研究生/博士
1988-09~1992-06,浙江医科大学, 大学本科

2024-01-01-今,中国医药创新促进会, 副会长
2023-09-01-今,中国药学会, 第二十五届理事会副理事长
2022-08-31-2023-12-30,中国医药创新促进会, 会长

   

（1） 2023年浦东新区明珠领军人才, 市地级, 2023
（2） 第三批国家“万人计划”科技创新领军人才, 国家级, 2017
（3） 2016年上海领军人才, 省级, 2016
（4） 中青年科技创新领军人才, 国家级, 2016
（5） 国家百千万人才工程, 国家级, 2014
（6） 第十一届中国科学院杰出青年, 一等奖, 省级, 2012
（7） 上海药学科技奖, 一等奖, 省级, 2011
（8） 第十二届中国青年科技奖, , 国家级, 2011
（9） 赛诺菲-安万特—中科院上海生命科学研究院优秀青年人才奖励基金, , 省级, 2011
（10） 国家科学技术进步二等奖, 二等奖, 国家级, 2003
（11） 上海市科技进步一等奖, 一等奖, 省级, 2002

（ 1 ） 一类丙烯酸类化合物及其制备方法、药物组合物和用途, 2023, 第 3 作者, 专利号: CN112204018B

（ 2 ） 一种5-苄基-2-氨基-1,3-噻唑类衍生物及其合成方法与应用, 2023, 第 3 作者, 专利号: CN116621794A

（ 3 ） 4,5-二氢吡唑并[1,5-a]喹喔啉-4-酮类化合物及制备和应用, 2023, 第 4 作者, 专利号: CN116621841A

（ 4 ） 一类含氧五元杂环化合物、合成方法、药物组合物及用途, 2023, 第 3 作者, 专利号: CN114605401B

（ 5 ） 长效Exendin-9-39及其在低血糖治疗中的应用和作为治疗低血糖的药物, 2023, 第 3 作者, 专利号: CN116606367A

（ 6 ） 一种葡萄糖激酶激动剂及其制备方法和应用, 2023, 第 3 作者, 专利号: CN115368352B

（ 7 ） 一种糖基没食子酸类衍生物及其制备方法与在制备乳腺癌靶向诊疗材料中的应用, 2023, 第 2 作者, 专利号: CN116535449A

（ 8 ） 一类含氧五元杂环化合物、合成方法、药物组合物及用途, 2023, 第 3 作者, 专利号: CN114573575B

（ 9 ） 一种糖基没食子酸类衍生物及制备方法与在制备肝脏疾病靶向诊疗材料中的应用, 2023, 第 2 作者, 专利号: CN116514883A

（ 10 ） 糖靶向的GSH响应紫杉醇衍生物及其制备方法和应用, 2023, 第 2 作者, 专利号: CN116514744A

（ 11 ） FXR小分子激动剂及其制备方法和用途, 2023, 第 2 作者, 专利号: CN111825667B

（ 12 ） 异吲哚啉类化合物、其制备方法、药物组合物及用途, 2023, 第 2 作者, 专利号: CN114085212B

（ 13 ） 苯并噻二唑类化合物在制备抗SARS-COV-2新型冠状病毒药物中的应用, 2023, 第 2 作者, 专利号: CN114159433B

（ 14 ） 冠状病毒包膜蛋白E诱导的胞外囊泡及其制法与应用, 2023, 第 4 作者, 专利号: CN115960835A

（ 15 ） 2-吡啶取代脲结构小分子化合物及其合成和应用, 2023, 第 2 作者, 专利号: CN110818683B

（ 16 ） 一类含氟异噁唑类化合物及其制备方法、药物组合物和用途, 2023, 第 2 作者, 专利号: CN110452235B

（ 17 ） 一种具有2-氨基嘧啶结构的化合物，其制备方法和用途, 2023, 第 4 作者, 专利号: CN109810110B

（ 18 ） 木姜叶柯提取物、制备方法和在降血糖方面的应用, 2022, 第 5 作者, 专利号: 202211708644.7

（ 19 ） 一类喹啉类化合物及其制备方法、药物组合物和用途, 2022, 第 3 作者, 专利号: PCT/CN2022/142988

（ 20 ） 一种β-半乳糖苷酶活化的ABT-263前药及其制备方法与应用, 2022, 第 2 作者, 专利号: CN115505016A

（ 21 ） 一种葡萄糖激酶激动剂及其制备方法和应用, 2022, 第 3 作者, 专利号: CN115368352A

（ 22 ） 抑制SHP2活性的杂环化合物、其制备方法及用途(PCT), 2022, 第 2 作者, 专利号: WO2022237367A1

（ 23 ） 一种喹啉类化合物、合成方法、药物组合物及用途, 2022, 第 3 作者, 专利号: CN115197240A

（ 24 ） 杂环-三氮唑并噻二唑杂环串联化合物、合成方法、药物组合物及用途, 2022, 第 2 作者, 专利号: CN114920759A

（ 25 ） 天然美登素类化合物及其在制药中的用途, 2022, 第 2 作者, 专利号: CN114805391A

（ 26 ） 抑制SHP2活性的杂环化合物、其制备方法及用途, 2022, 第 2 作者, 专利号: CN114716448A

（ 27 ） 噻唑类化合物在制备抗SARS-COV-2新型冠状病毒药物中的应用, 2022, 第 3 作者, 专利号: CN114681454A

（ 28 ） 一类含氧五元杂环化合物、合成方法、药物组合物及用途, 2022, 第 3 作者, 专利号: CN114605401A

（ 29 ） 一类含氧五元杂环化合物、合成方法、药物组合物及用途, 2022, 第 3 作者, 专利号: CN114573575A

（ 30 ） 一类含氧五元杂环化合物、合成方法、药物组合物及用途, 2022, 第 2 作者, 专利号: CN114516867A

（ 31 ） 异喹啉类化合物及其制备方法和应用, 2022, 第 4 作者, 专利号: CN114375293A

（ 32 ） FXR小分子激动剂及其制备方法和用途, 2022, 第 2 作者, 专利号: CN114315830A

（ 33 ） 苯并噻二唑类化合物在制备抗SARS-COV-2新型冠状病毒药物中的应用, 2022, 第 2 作者, 专利号: CN114159433A

（ 34 ） 异吲哚啉类化合物、其制备方法、药物组合物及用途, 2022, 第 2 作者, 专利号: CN114085212A

（ 35 ） 异吲哚啉类化合物、其制备方法、药物组合物及用途, 2022, 第 2 作者, 专利号: CN110963994B

（ 36 ） 247种化合物及其组合物在抗新型冠状病毒感染中的应用, 2022, 第 1 作者, 专利号: CN113893345A

（ 37 ） 1869种化合物及其组合物在抗新型冠状病毒感染中的应用, 2022, 第 1 作者, 专利号: CN113893347A

（ 38 ） N 2 -取代烷氧芳环-2-氨基嘧啶类衍生物及应用, 2021, 第 2 作者, 专利号: CN111646978B

（ 39 ） 一种momordin Ib的制备方法, 2021, 第 2 作者, 专利号: CN111848716B

（ 40 ） 奈非那韦在制备防治非酒精性脂肪性肝炎和/或抗肝纤维化药物中的应用, 2021, 第 2 作者, 专利号: CN113521072A

（ 41 ） 霉酚酸或含霉酚酸的组合制剂在抗冠状病毒中的应用, 2021, 第 7 作者, 专利号: CN113491699A

（ 42 ） 布鲁顿酪氨酸激酶抑制剂, 2021, 第 2 作者, 专利号: CN108349940B

（ 43 ） N-多取代吡啶-2-氨基嘧啶类衍生物及用途, 2021, 第 2 作者, 专利号: CN111253370B

（ 44 ） 含巯基荧光化合物或其硫酯衍生物及制备和应用, 2021, 第 2 作者, 专利号: CN111269160B

（ 45 ） N-取代芳环-2-氨基嘧啶类化合物及用途, 2021, 第 2 作者, 专利号: CN110872277B

（ 46 ） 一种基因工程菌及其构建方法和用途, 2021, 第 2 作者, 专利号: CN112795494A

（ 47 ） 多取代异吲哚啉类化合物、其制备方法、药物组合物及用途, 2021, 第 2 作者, 专利号: CN112745298A

（ 48 ） 一种双芳基马来酰亚胺类化合物及其药学上可接受的盐及其制备方法和应用, 2021, 第 2 作者, 专利号: CN109535158B

（ 49 ） 一种大环结构的IDH2突变体抑制剂及其医药用途, 2021, 第 3 作者, 专利号: CN111087408B

（ 50 ） 一类含氮杂环化合物、其制备方法和用途, 2021, 第 2 作者, 专利号: CN112300154A

（ 51 ） 稠环嘧啶氨基化合物、其制备方法、药物组合物及应用, 2021, 第 2 作者, 专利号: CN112239459A

（ 52 ） 一类丙烯酸类化合物及其制备方法、药物组合物和用途, 2021, 第 3 作者, 专利号: CN112204018A

（ 53 ） 一类含氧五元杂环化合物、合成方法、药物组合物及用途, 2020, 第 2 作者, 专利号: CN111848599A

（ 54 ） FXR小分子激动剂及其制备方法和用途, 2020, 第 2 作者, 专利号: CN111825667A

（ 55 ） 一类来那度胺/泊马度胺类似物及其应用, 2020, 第 5 作者, 专利号: CN111747924A

（ 56 ） N 2 -氨甲酰芳环-2-氨基嘧啶类衍生物及其医药用途, 2020, 第 2 作者, 专利号: CN111732548A

（ 57 ） 一类异吲哚啉类化合物、其制备方法、药物组合物及其应用, 2020, 第 2 作者, 专利号: CN111285850A

（ 58 ） 一类细胞周期依赖性激酶的降解剂、其制备方法、药物组合物及其用途, 2020, 第 2 作者, 专利号: CN111065639A

（ 59 ） 一种二氢异吲哚-1H-吡唑并3,4-d嘧啶酮化合物、其制备方法和应用, 2020, 第 2 作者, 专利号: CN110872296A

（ 60 ） 一类细胞周期依赖性激酶的降解剂、其制备方法、药物组合物及其用途, 2020, 第 2 作者, 专利号: CN110835345A

（ 61 ） 2-吡啶取代脲结构小分子化合物及其合成和应用, 2020, 第 2 作者, 专利号: CN110818683A

（ 62 ） 3-烯基吲哚酮类化合物的盐、其晶型、其药物组合物及其用途, 2020, 第 4 作者, 专利号: CN110655484A

（ 63 ） 一类SIRT2抑制剂、其制备方法及用途, 2019, 第 2 作者, 专利号: CN110551048A

（ 64 ） 一类含氟异噁唑类化合物及其制备方法、药物组合物和用途, 2019, 第 2 作者, 专利号: CN110452235A

（ 65 ） 含有根皮苷和1-脱氧野尻霉素的组合物及其应用, 2019, 第 6 作者, 专利号: CN110384709A

（ 66 ） 胆酸衍生物及其制备方法和用途, 2019, 第 2 作者, 专利号: CN110343140A

（ 67 ） 一种噻吩3,2-d并嘧啶-4-酮类化合物的药物新用途, 2019, 第 2 作者, 专利号: CN110240603A

（ 68 ） 一类噻吩并3,2-d嘧啶衍生物、其制备方法、药物组合物与用途, 2019, 第 2 作者, 专利号: CN110204552A

（ 69 ） 一类含环丙胺结构的噻吩并3,2-d嘧啶衍生物、其制备方法与用途, 2019, 第 2 作者, 专利号: CN110204551A

（ 70 ） 一类IDH1突变小分子抑制剂及其制备方法和用途, 2019, 第 2 作者, 专利号: CN109956930A

（ 71 ） 一种具有2-氨基嘧啶结构的化合物，其制备方法和用途, 2019, 第 4 作者, 专利号: CN109810110A

（ 72 ） 2’-C-甲基取代核苷类化合物及其制备与用途, 2019, 第 2 作者, 专利号: CN109748943A

（ 73 ） 一类芳基2,2’-串联双噻唑类化合物及其制备方法和用途, 2019, 第 2 作者, 专利号: CN109641888A

（ 74 ） 1,1a,6,6a-四氢环丙并a茚-1-胺衍生物及其制备方法与应用, 2019, 第 9 作者, 专利号: CN109535019A

（ 75 ） 一种双芳基马来酰亚胺类化合物及其药学上可接受的盐及其制备方法和应用, 2019, 第 2 作者, 专利号: CN109535158A

（ 76 ） 氨基喹唑啉酮和氨基异喹啉酮衍生物及其应用, 2019, 第 2 作者, 专利号: CN109516961A

（ 77 ） 布鲁顿酪氨酸激酶抑制剂, 2019, 第 2 作者, 专利号: CN109310671A

（ 78 ） 达玛烷型三萜衍生物的用途, 2019, 第 2 作者, 专利号: CN109223806A

（ 79 ） 一种二萜类化合物在制备治疗糖尿病或肥胖症的药物中的用途, 2019, 第 2 作者, 专利号: CN109125301A

（ 80 ） 一类氟取代的环丙胺类化合物及其制备方法、药物组合物和用途, 2018, 第 2 作者, 专利号: CN108779096A

（ 81 ） 苯并噻二唑类化合物、其制备方法及用途, 2018, 第 1 作者, 专利号: CN108341791A

（ 82 ） N-苄基-5/6-甲酰氨基吲哚-2-羧酸衍生物及其用途, 2018, 第 3 作者, 专利号: CN108349887A

（ 83 ） 布鲁顿酪氨酸激酶抑制剂, 2018, 第 2 作者, 专利号: CN108349940A

（ 84 ） 布鲁顿酪氨酸激酶抑制剂, 2018, 第 2 作者, 专利号: CN108349940A

（ 85 ） 三肽大环衍生物及其制备方法和应用, 2018, 第 2 作者, 专利号: CN108191957A

（ 86 ） 大环环氧酮肽类化合物及其制备方法和医药用途, 2018, 第 2 作者, 专利号: CN108117582A

（ 87 ） 组蛋白去乙酰化酶抑制剂及其应用, 2018, 第 4 作者, 专利号: CN107879975A

（ 88 ） 一类芳基2,2’‑串联双噻唑类化合物及其制备方法和用途, 2018, 第 2 作者, 专利号: CN107793375A

（ 89 ） 一种C,O‑螺环芳基糖苷类化合物及其制备和应用, 2018, 第 2 作者, 专利号: CN107709332A

（ 90 ） 反吲哚啉环丙胺类化合物及其制备方法、药物组合物和用途, 2017, 第 2 作者, 专利号: CN107459476A

（ 91 ） 一种苯g杂芳基并a,g喹嗪类化合物的药物用途及其制备方法, 2017, 第 2 作者, 专利号: CN107303298A

（ 92 ） 一种DPPIV抑制剂的盐型及其制备方法, 2017, 第 4 作者, 专利号: CN107216340A

（ 93 ） 一种DPPIV抑制剂马来酸盐的多晶型及其制备方法, 2017, 第 4 作者, 专利号: CN107216339A

（ 94 ） 一类氟取代的环丙胺类化合物及其制备方法、药物组合物和用途, 2017, 第 2 作者, 专利号: CN107200706A

（ 95 ） 含小檗碱和知母皂苷的组合物及其应用, 2017, 第 2 作者, 专利号: CN107184590A

（ 96 ） 海藻倍半萜类化合物、其制备方法及用途, 2017, 第 2 作者, 专利号: CN107176936A

（ 97 ） 一类脂肪酸类化合物、其制备方法及其用途, 2017, 第 2 作者, 专利号: CN107118098A

（ 98 ） 3-烯基吲哚酮类衍生物在制备治疗MIRI药物中的用途及其药物组合物, 2017, 第 3 作者, 专利号: CN106619616A

（ 99 ） 一类组蛋白去甲基化酶JMJD3抑制剂及其制备方法和用途, 2017, 第 5 作者, 专利号: CN106608869A

（ 100 ） 2‑多取代芳环‑嘧啶类衍生物及制备和医药用途, 2017, 第 2 作者, 专利号: CN106588884A

（ 101 ） 2‑取代芳环‑嘧啶类衍生物及制备和应用, 2017, 第 2 作者, 专利号: CN106588885A

（ 102 ） 含有螺甾烷化合物的组合物及其用途, 2017, 第 2 作者, 专利号: CN106551943A

（ 103 ） 一种C,O-螺环芳基糖苷类化合物及其制备和应用, 2017, 第 2 作者, 专利号: CN106317068A

（ 104 ） 香兰胺/香兰醇衍生物及其制备方法和应用, 2016, 第 2 作者, 专利号: CN106032367A

（ 105 ） 一种化合物的A晶型及其制备方法, 2016, 第 4 作者, 专利号: CN105985353A

（ 106 ） 一类吡唑酮化合物及其用途, 2016, 第 2 作者, 专利号: CN105315275A

（ 107 ） N-苄基-5/6-甲酰氨基吲哚-2-羧酸衍生物及其用途, 2015, 第 3 作者, 专利号: CN105175309A

（ 108 ） 一类2,2’-串联双噻唑类化合物及其制备方法和用途, 2015, 第 2 作者, 专利号: CN104974108A

（ 109 ） 杂环构建的三肽环氧酮类化合物及制备和应用, 2015, 第 2 作者, 专利号: CN104945470A

（ 110 ） 一类螺异噁唑啉衍生物、其制备方法及医药用途, 2015, 第 1 作者, 专利号: CN104945416A

（ 111 ） 取代哌啶类衍生物、含其的药物组合物及其在抗肿瘤中的应用, 2015, 第 3 作者, 专利号: CN104926788A

（ 112 ） 取代氮杂环类衍生物、含其的药物组合物及其在抗肿瘤中的应用, 2015, 第 4 作者, 专利号: CN104926801A

（ 113 ） 4,4-二甲基石胆酸-2,3-骈N-芳基吡唑衍生物及其制备方法和应用, 2015, 第 3 作者, 专利号: CN104892720A

（ 114 ） 苯并杂环取代1,3,4-噁二唑类化合物及其制备方法和应用, 2015, 第 3 作者, 专利号: CN104892590A

（ 115 ） 一类苯环-芳香环串联化合物、其制备方法和医药用途, 2015, 第 1 作者, 专利号: CN104788410A

（ 116 ） 一类2,3-二氢萘嵌间二氮杂苯类似物、其合成方法、药物组合物及用途, 2015, 第 2 作者, 专利号: CN104418811A

（ 117 ） β-芳香基硫醚取代的α,β-环烯酮衍生物及其制备方法和应用, 2015, 第 2 作者, 专利号: CN104356079A

（ 118 ） 9-取代氨基-13-烃基双取代小檗碱衍生物及其制备方法和应用, 2015, 第 3 作者, 专利号: CN104327069A

（ 119 ） N-(1,3-二氧代异吲哚啉)芳酰胺类化合物及其制备方法和应用, 2014, 第 2 作者, 专利号: CN104230787A

（ 120 ） 茜草科类型环肽制备方法及其用作为Hippo-YAP信号通路抑制剂, 2014, 第 6 作者, 专利号: CN104193808A

（ 121 ） 一种含硫脲基噻吩类化合物及其应用, 2014, 第 1 作者, 专利号: CN104130240A

（ 122 ） 酰胺苯基-1,3,4-噁二唑类化合物及其制备方法和应用, 2014, 第 3 作者, 专利号: CN104098526A

（ 123 ） 一类二氢嘧啶酮类化合物及其用途, 2014, 第 2 作者, 专利号: CN104017002A

（ 124 ） 木果楝碱甲素、其制备方法和其用途, 2014, 第 1 作者, 专利号: CN103880854A

（ 125 ） 羟乙基吡唑类化合物或氨乙基吡唑类化合物及其制备方法和用途, 2014, 第 2 作者, 专利号: CN103508957A

（ 126 ） 丁-2-烯-1,4-二酮类化合物及其制备方法和用途, 2013, 第 3 作者, 专利号: CN103420894A

（ 127 ） 一种脲类化合物、制备方法及其用途, 2013, 第 3 作者, 专利号: CN103172543A

（ 128 ） 一种3-苯并异噁唑-4-吲哚马来酰亚胺衍生物及其用途, 2013, 第 2 作者, 专利号: CN103130790A

（ 129 ） 噻吩3,2-d并嘧啶-4-酮类化合物、其制备方法、药物组合物及用途, 2013, 第 2 作者, 专利号: CN103130819A

（ 130 ） 2,5-二芳基-1,3,4-噁二唑类化合物及其制备和应用, 2013, 第 1 作者, 专利号: CN102924399A

（ 131 ） 拟海桑内酯甲素、其制备方法和用途以及含有该拟海桑内酯甲素的药物组合物, 2013, 第 2 作者, 专利号: CN102887906A

（ 132 ） 四氢吡啶并噻唑类化合物、其制备方法、包含该化合物的药物组合物及其用途, 2012, 第 2 作者, 专利号: CN102838625A

（ 133 ） 茜草科类型环肽及其药物组合物和应用, 2012, 第 5 作者, 专利号: CN102816212A

（ 134 ） 一类噻唑类化合物及其制备方法和用途, 2012, 第 4 作者, 专利号: CN102775368A

（ 135 ） 二萜化合物豆荚丙素或丁素及其在制备药物中的用途, 2012, 第 1 作者, 专利号: CN102731242A

（ 136 ） 二萜类化合物豆荚甲素—己素、其制备方法及其在制备药物中的用途, 2012, 第 2 作者, 专利号: CN102731277A

（ 137 ） 2-((2-(3-氨基哌啶-1)-4-氧噻吩3,2-d嘧啶-3(4H)-甲基)苯甲腈多晶型体、其制备方法及其药理用途, 2012, 第 2 作者, 专利号: CN102659813A

（ 138 ） 一类二硫醚类化合物及其制备方法和用途, 2012, 第 2 作者, 专利号: CN102643247A

（ 139 ） 含有异羟肟酸结构的表鬼臼毒化合物及制备方法和用途, 2012, 第 5 作者, 专利号: CN102603761A

（ 140 ） 联苯亚甲基-2-硫代-4-噻唑酮类化合物及其制备方法和用途, 2012, 第 2 作者, 专利号: CN102558088A

（ 141 ） 羟乙基三唑类化合物或氨乙基三唑类化合物及其制备方法和用途, 2012, 第 2 作者, 专利号: CN102558157A

（ 142 ） 一种抗糖尿病化合物及其制备方法和用途, 2012, 第 2 作者, 专利号: CN101775008B

（ 143 ） 毛红椿醛及其制备方法和用途, 2012, 第 2 作者, 专利号: CN102311473A

（ 144 ） 一类新型嘧啶类小分子化合物、其制备方法及其用途, 2011, 第 7 作者, 专利号: CN101033224B

（ 145 ） 一类喹喔啉类衍生物、制法及用途, 2011, 第 2 作者, 专利号: CN1966500B

（ 146 ） 一种苯乙烯苯酚类化合物作为制备胰岛素增敏剂的用途, 2011, 第 2 作者, 专利号: CN101953820A

（ 147 ） 茜草科类型环肽,以其为活性成分的药物组合物,其制备方法和应用, 2010, 第 5 作者, 专利号: CN101921319A

（ 148 ） 一种芳香类化合物作为制备Caspase 3抑制剂的用途, 2010, 第 3 作者, 专利号: CN101919833A

（ 149 ） 2-乙酰氨基龙胆酸作为制备胰岛素增敏剂的用途, 2010, 第 2 作者, 专利号: CN101919835A

（ 150 ） 8,8-二取代-13,13a-二氢小檗碱衍生物及其药物组合物和用途, 2010, 第 2 作者, 专利号: CN101870694A

（ 151 ） 二氢吡咯酮衍生物作为Caspase-3抑制剂, 2010, 第 3 作者, 专利号: CN101838260A

（ 152 ） 一类新的DPP-Ⅳ抑制剂及其制备方法和用途, 2010, 第 2 作者, 专利号: CN101823987A

（ 153 ） 一种可用作人源腺苷单核苷酸激活蛋白激酶激活剂的化合物及其制备方法和应用, 2010, 第 2 作者, 专利号: CN1978445B

（ 154 ） 一类苯并噻吩类化合物、及制备和它的医药用途, 2010, 第 2 作者, 专利号: CN1548434B

（ 155 ） 联苯化合物及其制备方法和用途, 2010, 第 2 作者, 专利号: CN101768132A

（ 156 ） 山楂酸衍生物及其制备和应用, 2010, 第 2 作者, 专利号: CN101619088A

（ 157 ） 蛋白酪氨酸磷酸酯酶1B抑制剂1，3－二羟基－5－烷基苯类化合物的用途, 2009, 第 3 作者, 专利号: CN100506769C

（ 158 ） α－氨基－N－取代酰胺化合物、包含该化合物的药物组合物及其用途, 2009, 第 2 作者, 专利号: CN101456824A

（ 159 ） 苄基哌啶类化合物及其制备方法和用途, 2009, 第 2 作者, 专利号: CN101348456A

（ 160 ） 一类萘并呋喃邻醌化合物及其制备方法和用途, 2008, 第 1 作者, 专利号: CN101274925A

（ 161 ） 蛋白酪氨酸磷酸酯酶1B抑制剂及其制备方法和用途, 2008, 第 2 作者, 专利号: CN101260086A

（ 162 ） 13,13a－二氢小檗碱衍生物及其药物组合物和用途, 2008, 第 2 作者, 专利号: CN101153039A

（ 163 ） 一类α－氨基－N－取代酰胺化合物、其组合物及用途, 2007, 第 2 作者, 专利号: CN101092384

（ 164 ） 一类新颖的2’－α－羟烷基紫杉烷类化合物及其制备方法, 2007, 第 3 作者, 专利号: CN101081841A

（ 165 ） 一类3,4－二氢－1H－2－苯并吡喃－1－酮类化合物、制备方法和用途, 2007, 第 2 作者, 专利号: CN1911925A

（ 166 ） 一类小分子探针设计的结构模块、制备方法及用途, 2007, 第 2 作者, 专利号: CN1908661A

（ 167 ） 粗枝藻甲素的用途, 2007, 第 2 作者, 专利号: CN1903210A

（ 168 ） 那卡呋喃－8内酯的用途, 2007, 第 2 作者, 专利号: CN1903193A

（ 169 ） 一类光亲和标记双功能探针分子、制备及应用, 2007, 第 2 作者, 专利号: CN1900101A

（ 170 ） 一类二肽酶四抑制剂及其制备方法和用途, 2007, 第 1 作者, 专利号: CN1891704A

（ 171 ） 一类萘并二氢呋喃邻醌化合物、制备方法及用途, 2006, 第 2 作者, 专利号: CN1884273A

（ 172 ） 一类4－羟基戊酰胺类化合物及其制备方法和用途, 2006, 第 2 作者, 专利号: CN1757635A

（ 173 ） 蛋白酪氨酸磷酸酯酶1B抑制剂桐花醇类化合物的制备方法及其用途, 2005, 第 3 作者, 专利号: CN1680235A

（ 174 ） 蛋白酪氨酸磷酸酯酶1B抑制剂1，3－二羟基－5－烷基苯类化合物的制备方法及其用途, 2005, 第 3 作者, 专利号: CN1680238A

（ 175 ） 蛋白酪氨酸磷酸酯酶1B抑制剂γ－丁内酯类化合物、制备方法和用途, 2005, 第 4 作者, 专利号: CN1666986A

（ 176 ） 一种枇杷叶总三萜酸及其制备方法和用途, 2005, 第 2 作者, 专利号: CN1640885A

（ 177 ） 人源甲硫氨酰氨肽酶1的表达方法及它在寻找抗肿瘤药物中应用, 2005, 第 1 作者, 专利号: CN1609221A

（ 178 ） 一类芳香酰胺化合物、制备方法及用途, 2005, 第 3 作者, 专利号: CN1597662A

（ 179 ） 一类杂环衍生物、制备方法及其用途, 2005, 第 2 作者, 专利号: CN1580056A

（ 180 ） 茚酮并吲哚类化合物、制备方法及它的医学用途, 2005, 第 3 作者, 专利号: CN1566092A

（ 181 ） 异喹啉－1,3,4－三酮类化合物、制备方法及其用途, 2005, 第 2 作者, 专利号: CN1566099A

（ 182 ） 蛋白酪氨酸磷酸酯酶1B抑制剂对苯醌类化合物及其制备方法, 2004, 第 2 作者, 专利号: CN1521157

（ 183 ） 对－苯醌类化合物、及其制备方法和它的用途, 2004, 第 2 作者, 专利号: CN1513828

（ 184 ） 紫杉烷类化合物、合成方法及其用途, 2004, 第 2 作者, 专利号: CN1513850

（ 185 ） 四氢异喹啉羟肟酸磺酰胺类化合物、合成方法及其用途, 2002, 第 4 作者, 专利号: CN1380288A

（ 186 ） (4－炔基)－芳香酮酸类化合物、合成方法及应用, 2002, 第 4 作者, 专利号: CN1380279A

   

（1） 转录因子的入核转运调控机制, Nuclear Translocation Mechanism of Transcription Factors, 中国生物化学与分子生物学报, 2023, 第 2 作者
（2） Discovery of novel non-peptidic and non-covalent small-molecule 3CLpro inhibitors as potential candidate for COVID-19 treatment, Signal Transduction and Targeted Therapy, 2023, 第 6 作者
（3） Gut Microbiota Metabolite 3-Indolepropionic Acid Directly Activates Hepatic Stellate Cells by ROS/JNK/p38 Signaling Pathways, BIOMOLECULES, 2023, 第 4 作者  通讯作者
（4） APEX/APEX2邻近标记方法在膜蛋白研究中的应用, The Application of APEX/APEX2-Based Proximity Labeling in MP Research, 中国细胞生物学学报, 2023, 第 3 作者
（5） Phosphorylation of PHF2 by AMPK releases the repressive H3K9me2 and inhibits cancer metastasis., Signal Transduction and Targeted Therapy., 2023, 
（6） Anxiolytic effect of antidiabetic metformin is mediated by AMPK activation in mPFC inhibitory neurons., Molecular Psychiatry., 2023, 
（7） Targeting C/EBP�� overcomes primary resistance and improves the efficacy of FLT3 inhibitors in acute myeloid leukaemia., Nature Communications., 2023, 
（8） Hepatic glucuronyl C5-epimerase combats obesity by stabilising GDF15., Journal of Hepatology., 2023, 
（9） Orthogonally Engineered Albumin with Attenuated Macrophage Phagocytosis for the Targeted Visualization and Phototherapy of Liver Cancer., Journal of the American Chemical Society, 2023, 
（10） 生物医药那片海, 家庭用药, 2022, 第 1 作者
（11） Dual inhibition of CHK1/FLT3 enhances cytotoxicity and overcomes adaptive and acquired resistance in FLT3-ITD acute myeloid leukemia., Leukemia., 2022, 第 10 作者
（12） Discovery of a Potent and Selective Degrader for USP7., Angew Chem Int Ed Engl., 2022, 第 9 作者
（13） Inner nuclear membrane protein TMEM201 promotes breast cancer metastasis by positive regulating TGF�� signaling., Oncogene., 2022, 
（14） Inner nuclear membrane protein TMEM201 maintains endothelial cell migration and angiogenesis by interacting with the LINC complex., J Mol Cell Biol., 2022, 第 6 作者  通讯作者
（15） Discovery of 4-cyclopropyl-3-(2-((1-cyclopropyl-1H-pyrazol-4-yl) amino) quinazolin-6-yl)-N-(3-(trifluoromethyl) phenyl) benzamides as potent discoidin domain receptor inhibitors for the treatment of idiopathic pulmonary fibrosis., Acta Pharm Sin B., 2022, 第 10 作者
（16） Molecularly engineered AIEgens with enhanced quantum and singlet-oxygen yield for mitochondria-targeted imaging and photodynamic therapy., Chem. Sci., 2022, 第 6 作者  通讯作者
（17） 5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 第 18 作者  通讯作者
（18） Synthesis of 2-ethoxycarbonylthieno2,3-bquinolines in biomass-derived solvent gamma-valerolactone and their biological evaluation against protein tyrosine phosphatase 1B, RSC ADVANCES, 2021, 第 7 作者
（19） Bioinspired Design of Reversible Fluorescent Probes for Tracking Nitric Oxide Dynamics in Live Cells, CCS CHEMISTRY, 2021, 第 6 作者
（20） SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target, Cell Research, 2021, 第 33 作者  通讯作者
（21） Fluorescent probes for the imaging of lipid droplets in live cells, COORDINATION CHEMISTRY REVIEWS, 2021, 第 9 作者  通讯作者
（22） Guaianolide sesquiterpene lactones from Achillea millefolium L, PHYTOCHEMISTRY, 2021, 第 6 作者  通讯作者
（23） Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies, ACTA PHARMACOLOGICA SINICA, 2021, 第 22 作者  通讯作者
（24） 新型含咔唑环和芳环/芳稠杂环的N-酰腙衍生物的合成及蛋白酪氨酸磷酸酶1B （PTP1B）抑制活性评价, Synthesis and Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Activity Evaluation of Novel N-Acylhydrazone Derivatives Containing Carbazole and Aromatic Ring/Aromatic Fused Heterocycle, 有机化学, 2021, 第 9 作者
（25） Highly Oxygenated Triterpenoids and Diterpenoids from Fructus Rubi (Rubus chingii Hu) and Their NF-kappa B Inhibitory Effects, MOLECULES, 2021, 第 9 作者  通讯作者
（26） 新型含咔唑环芳氨基乙酰腙衍生物的合成及其蛋白酪氨酸磷酸酶1B （PTP1B）抑制活性评价, Synthesis and Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Activity Evaluation of Novel Arylaminoacetylhydrazone Derivatives Containing Carbazole Moiety, 有机化学, 2021, 第 7 作者
（27） Sesquiterpene coumarins from Ferula samarkandica Korovin and their bioactivity, PHYTOCHEMISTRY, 2021, 第 7 作者  通讯作者
（28） Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice, Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice, ACTA PHARMACOLOGICA SINICA, 2021, 第 10 作者  通讯作者
（29） Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 第 14 作者  通讯作者
（30） Optimization of piperidine constructed peptidyl derivatives as proteasome inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 第 9 作者  通讯作者
（31） Inhibition of B-cell receptor signaling disrupts cell adhesion in mantle cell lymphoma via RAC2, BLOOD ADVANCES, 2021, 第 14 作者
（32） Beneficial effects exerted by hydroxychloroquine in treating COVID-19 patients via protecting multiple organs, Beneficial effects exerted by hydroxychloroquine in treating COVID-19 patients via protecting multiple organs, SCIENCE CHINA-LIFE SCIENCES, 2021, 第 4 作者
（33） Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia, JOURNAL OF MEDICINAL CHEMISTRY, 2021, 第 13 作者
（34） Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia, CHEMMEDCHEM, 2021, 第 9 作者  通讯作者
（35） Discovery of 2-(5-(quinolin-6-yl)-1,3,4-oxadiazol-2-yl)acetamide derivatives as novel PI3K�� inhibitors via docking-based virtual screening, BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 第 5 作者  通讯作者
（36） Phosphoproteomics Reveals AMPK Substrate Network in Response to DNA Damage and Histone Acetylation, GENOMICS, PROTEOMICS & BIOINFORMATICS, 2021, 第 8 作者  通讯作者
（37） Discovery of 2-(5-(quinolin-6-yl)-1,3,4-oxadiazol-2-yl)acetamide derivatives as novel PI3K alpha inhibitors via docking-based virtual screening, BIOORGANICMEDICINALCHEMISTRY, 2021, 第 5 作者  通讯作者
（38） Development of peptide epoxyketones as selective immunoproteasome inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 第 6 作者  通讯作者
（39） AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ, CELL REPORTS, 2021, 第 7 作者  通讯作者
（40） Phosphoproteomics Reveals AMPK Substrate Network in Response to DNA Damage and Histone Acetylation., Genomics Proteomics Bioinformatics., 2021, 
（41） Synthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 第 10 作者
（42） Diffuse large B-cell lymphoma with low F-18-fluorodeoxyglucose avidity features silent B-cell receptor signaling, LEUKEMIALYMPHOMA, 2020, 第 7 作者
（43） Microenvironment-Responsive Small-Molecule Probe for Pulmonary Fibrosis Detection, ANALYTICAL CHEMISTRY, 2020, 第 9 作者
（44） 3，6-二取代三唑并噻二唑衍生物的合成及其对细胞分裂周期25B磷酸酶和蛋白酪氨酸磷酸酶1B抑制活性评价, Synthesis of 3,6-Disubstituted Triazolothiadiazole Derivatives and Their Inhibitory Activities Against Cell Division Cycle 25B Phosphatase and Protein Tyrosine Phosphatase 1B, 应用化学, 2020, 第 9 作者
（45） The triterpenoid sapogenin (2 alpha-OH-Protopanoxadiol) ameliorates metabolic syndrome via the intestinal FXR/GLP-1 axis through gut microbiota remodelling, CELL DEATH & DISEASE, 2020, 第 12 作者
（46） Synthesis and in Vitro and in Vivo Biological Evaluation of Tissue-Specific Bisthiazole Histone Deacetylase (HDAC) Inhibitors, JOURNAL OF MEDICINAL CHEMISTRY, 2020, 第 10 作者  通讯作者
（47） Protein encapsulation: a new approach for improving the capability of small-molecule fluorogenic probes, CHEMICAL SCIENCE, 2020, 第 13 作者  通讯作者
（48） Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19, Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19, SCIENCE CHINA-LIFE SCIENCES, 2020, 第 6 作者
（49） Pinkment: a synthetic platform for the development of fluorescent probes for diagnostic and theranostic applications, CHEMICAL SCIENCE, 2020, 第 10 作者  通讯作者
（50） Discovery of a Potent and Selective NF-kappa B-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo, JOURNAL OF MEDICINAL CHEMISTRY, 2020, 第 13 作者  通讯作者
（51） 基于咔唑的新型碳酰腙衍生物的合成及蛋白酪氨酸磷酸酶1B（PTP1B）抑制活性评价, Synthesis and Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Activity Evaluation of Novel Carbazole-Based Carbohydrazone Derivatives, 有机化学, 2020, 第 9 作者
（52） 基于咔唑的单-/双-硫代碳酰腙衍生物的合成及Cdc25B/PTP1B抑制活性评价, Synthesis and Cdc25B/PTP1B Inhibitory Activity Evaluation of Novel Carbazole-Based Mono-/Bis-thiocarbohydrazone Derivatives, 有机化学, 2020, 第 9 作者
（53） Hyperprins A and B, Two Complex Meroterpenoids from Hypericum przewalskii, ORGANIC LETTERS, 2020, 第 7 作者
（54） Synthesis and Cdc25B/PTP1B Inhibitory Activity Evaluation of Novel Carbazole-Based Mono-/Bis-thiocarbohydrazone Derivatives, CHINESEJOURNALOFORGANICCHEMISTRY, 2020, 第 9 作者  通讯作者
（55） Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19 (vol 84, pg 913, 2020), SCIENCE CHINA-LIFE SCIENCES, 2020, 第 6 作者
（56） Spirobiflavonoid stereoisomers from the endangered conifer Glyptostrobus pensilis and their protein tyrosine phosphatase 1B inhibitory activity, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 第 6 作者  通讯作者
（57） Photochromic Fluorescent Probe Strategy for the Super-resolution Imaging of Biologically Important Biomarkers, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2020, 第 12 作者  通讯作者
（58） Design and synthesis of new lenalidomide analogs via Suzuki cross-coupling reaction, ARCHIV DER PHARMAZIE, 2020, 第 5 作者  通讯作者
（59） Supramolecular Assembly of TPE-Based Glycoclusters with Dicyanomethylene-4H-pyran (DM) Fluorescent Probes Improve Their Properties for Peroxynitrite Sensing and Cell Imaging, CHEMISTRY-A EUROPEAN JOURNAL, 2020, 第 7 作者  通讯作者
（60） The design of a novel near-infrared fluorescent HDAC inhibitor and image of tumor cells, BIOORGANIC & MEDICINAL CHEMISTRY, 2020, 第 5 作者
（61） Discovery of a 2-pyridinyl urea-containing compound YD57 as a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1), EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 第 8 作者  通讯作者
（62） Cyclodextrin-Based Peptide Self-Assemblies (Spds) That Enhance Peptide-Based Fluorescence Imaging and Antimicrobial Efficacy, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2020, 第 9 作者  通讯作者
（63） Stewartiacids A-N, C-23 carboxylated triterpenoids from Chinese Stewartia and their inhibitory effects against ATP-citrate lyase and NF-kappa B, RSC ADVANCES, 2020, 第 9 作者  通讯作者
（64） Identification and structural insight of an effective PPAR gamma modulator with improved therapeutic index for anti-diabetic drug discovery, CHEMICAL SCIENCE, 2020, 第 12 作者  通讯作者
（65） Discovery and Optimization of Non-bile Acid FXR Agonists as Preclinical Candidates for the Treatment of Nonalcoholic Steatohepatitis, JOURNAL OF MEDICINAL CHEMISTRY, 2020, 第 13 作者  通讯作者
（66） Synthesis and Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Activity Evaluation of Novel Carbazole-Based Carbohydrazone Derivatives, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 第 9 作者  通讯作者
（67） A fluorogenic probe for tracking GSH flux in developing neurons, CHEMICAL COMMUNICATIONS, 2020, 第 6 作者
（68） Design, Synthesis, and In Vitro Evaluation of Benzofuro3,2- c Quinoline Derivatives as Potential Antileukemia Agents, MOLECULES, 2020, 第 8 作者  通讯作者
（69） New Steroids from the South China Sea Soft Coral Lobophytum sp., CHEMISTRY & BIODIVERSITY, 2020, 第 3 作者
（70） Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 第 14 作者  通讯作者
（71） Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material (vol 55, pg 13235, 2019), CHEMICAL COMMUNICATIONS, 2020, 第 8 作者  通讯作者
（72） Selective and sensitive fluorescence imaging reveals microenvironment-dependent behavior of NO modulators in the endothelial system, Selective and sensitive fluorescence imaging reveals microenvironment-dependent behavior of NO modulators in the endothelial system, JOURNAL OF PHARMACEUTICAL ANALYSIS, 2020, 第 3 作者
（73） Phytochemical and biological studies on rare and endangered plants endemic to China. Part XV. Structurally diverse diterpenoids and sesquiterpenoids from the vulnerable conifer Pseudotsuga sinensis, PHYTOCHEMISTRY, 2020, 第 7 作者
（74） Design, synthesis, and biological evaluation of novel phenol ether derivatives as non-covalent proteasome inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 第 7 作者
（75） Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases, SMALL METHODS, 2019, 第 6 作者  通讯作者
（76） Design, synthesis and biological evaluation of the thioether-containing lenalidomide analogs with anti-proliferative activities, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 第 8 作者  通讯作者
（77） AMPK Promotes SPOP-Mediated NANOG Degradation to Regulate Prostate Cancer Cell Stemness, DEVELOPMENTAL CELL, 2019, 第 15 作者
（78） 含1H-苯并d咪唑或1H-苯并D1，2，3三唑结构的新型查尔酮衍生物的合成及PTP1B抑制活性研究, Synthesis and PTP1B Inhibitory Activity of Novel Chalcone Derivatives Bearing 1 H-Benzodimidazol or 1H-Benzod1,2,3triazol Moieties, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2019, 第 4 作者  通讯作者
（79） Berberine promotes the recruitment and activation of brown adipose tissue in mice and humans, CELL DEATH & DISEASE, 2019, 第 11 作者  通讯作者
（80） New sesquiterpenoids from the South China Sea soft corals Clavularia viridis and Lemnalia flava, BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2019, 第 5 作者
（81） New triterpenoids and PTP1B inhibitory constituents of Pseudolarix amabilis, FITOTERAPIA, 2019, 第 6 作者
（82） Alogliptin alleviates liver fibrosis via suppression of activated hepatic stellate cell, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 第 6 作者  通讯作者
（83） Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia via Promoting Glucose Oxidation, DIABETES, 2019, 第 17 作者  通讯作者
（84） Self-Assembled 2D Glycoclusters for the Targeted Delivery of Theranostic Agents to Triple-Negative Breast Cancer Cells, ACS APPLIED MATERIALS & INTERFACES, 2019, 第 8 作者  通讯作者
（85） 含1H-苯并d咪唑或1H-苯并d1，2，3三唑结构的新型查尔酮衍生物的合成及PTP1B抑制活性研究, Synthesis and PTP1B Inhibitory Activity of Novel Chalcone Derivatives Bearing 1H-Benzodimidazol or 1H-Benzod1,2,3triazol Moieties, 有机化学, 2019, 第 4 作者
（86） Design, synthesis and biological evaluation of 6-deoxy O-spiroketal C-arylglucosides as novel renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 第 11 作者  通讯作者
（87） Self-Assembled Thin-Layer Glycomaterials With a Proper Shell Thickness for Targeted and Activatable Cell Imaging, FRONTIERS IN CHEMISTRY, 2019, 第 7 作者
（88） Discovery of novel indoleaminopyrimidine NIK inhibitors based on molecular docking-based support vector regression (SVR) model, CHEMICAL PHYSICS LETTERS, 2019, 第 8 作者
（89） Discovery of a Natural-Product-Derived Preclinical Candidate for Once-Weekly Treatment of Type 2 Diabetes, JOURNAL OF MEDICINAL CHEMISTRY, 2019, 第 15 作者
（90） 含咔唑/苯并咪唑环的2，5-二取代-1，3，4-噻二唑酰胺衍生物的合成及对PTP1B/TCPTP抑制活性的评价, Synthesis and PTP1B/TCPTP Inhibitory Activity Evaluation of Novel 2,5-Disubstituted-1,3,4-thiadiazolamide Derivatives Containing Carbazole/Benzimidazole Moity, 有机化学, 2019, 第 9 作者
（91） Enantiomeric pairs of meroterpenoids from Rhododendron fastigiatum, Enantiomeric pairs of meroterpenoids from Rhododendron fastigiatum, CHINESE JOURNAL OF NATURAL MEDICINES, 2019, 第 5 作者
（92） Synthesis and PTP1B/TCPTP Inhibitory Activity Evaluation of Novel 2,5-Disubstituted-1,3,4-thiadiazolamide Derivatives Containing Carbazole/Benzimidazole Moity, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2019, 第 9 作者  通讯作者
（93） Synthesis and Cdc25B/PTP1B Inhibitory Activity Evaluation of Novel Acylhydrazone Derivatives Containing Carbazole Moity, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2019, 第 8 作者  通讯作者
（94） Covalent docking modelling-based discovery of tripeptidyl epoxyketone proteasome inhibitors composed of aliphatic-heterocycles, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 第 9 作者
（95） Identification of new NIK inhibitors by discriminatory analysis-based molecular docking and biological evaluation, ARCHIV DER PHARMAZIE, 2019, 第 6 作者
（96） Targeted photoswitchable imaging of intracellular glutathione by a photochromic glycosheet sensor, BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2019, 第 4 作者
（97） Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 第 12 作者  通讯作者
（98） Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design, JOURNAL OF MEDICINAL CHEMISTRY, 2019, 第 13 作者
（99） Alstonlarsines A-D, Four Rearranged Indole Alkaloids from Alstonia scholaris., ORGANIC LETTERS, 2019, 第 7 作者  通讯作者
（100） Synthesis and biological evaluation of 3-aryl-4-indolyl-maleimides as potent mutant isocitrate dehydrogenase-1 inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 第 10 作者  通讯作者
（101） Sulfuretin protects hepatic cells through regulation of ROS levels and autophagic flux, sulfuretinprotectshepaticcellsthroughregulationofroslevelsandautophagicflux, ACTA PHARMACOLOGICA SINICA, 2019, 第 4 作者  通讯作者
（102） Discovery of 1,3-diphenyl-1H-pyrazole derivatives containing rhodanine-3-alkanoic acid groups as potential PTP1B inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 第 5 作者  通讯作者
（103） Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material, CHEMICAL COMMUNICATIONS, 2019, 第 8 作者  通讯作者
（104） Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 第 7 作者  通讯作者
（105） Selective Late-Stage Oxygenation of Sulfides with Ground-State Oxygen by Uranyl Photocatalysis, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 第 7 作者
（106） Exploration of novel macrocyclic dipeptide N-benzyl amides as proteasome inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 第 8 作者
（107） SIRT5 Regulates Brown Adipocyte Differentiation and Browning of Subcutaneous White Adipose Tissue, DIABETES, 2019, 第 6 作者  通讯作者
（108） fDiscovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 第 10 作者  通讯作者
（109） Six new diterpenoids from Croton laevigatus, JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2018, 第 4 作者
（110） Novel substituted pyrazolone derivatives as AMP-activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice, ACTA PHARMACOLOGICA SINICA, 2018, 第 10 作者
（111） PTP1B inhibitory and cytotoxic C-24 epimers of Delta(28)-24-hydroxy stigmastane-type steroids from the brown alga Dictyopteris undulata Holmes, PHYTOCHEMISTRY, 2018, 第 4 作者
（112） 3-(7-Azaindolyl)-4-indolylmaleimides as a novel class of mutant isocitrate dehydrogenase-1 inhibitors: Design, synthesis, and biological evaluation, ARCHIV DER PHARMAZIE, 2018, 第 11 作者  通讯作者
（113） Structural, stereochemical, and bioactive studies of cembranoids from Chinese soft coral &ITSarcophyton trocheliophorum&IT, TETRAHEDRON, 2018, 第 5 作者
（114） Pyrazolo4,3-bpyrimido4,5-e1,4diazepine derivatives as new multi-targeted inhibitors of Aurora A/B and KDR, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 第 5 作者
（115） Flavans and diphenylpropanes with PTP1B inhibition from Broussonetia kazinoki, FITOTERAPIA, 2018, 第 6 作者
（116） AMP-Activated Protein Kinase (AMPK) Regulates Energy Metabolism through Modulating Thermogenesis in Adipose Tissue, FRONTIERS IN PHYSIOLOGY, 2018, 第 8 作者
（117） A novel series of 4-methyl substituted pyrazole derivatives as potent glucagon receptor antagonists: Design, synthesis and evaluation of biological activities, BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 第 6 作者
（118） Enantiomeric Pairs of Meroterpenoids with Diverse Heterocyclic Systems from Rhododendron nyingchiense, JOURNAL OF NATURAL PRODUCTS, 2018, 第 7 作者
（119） The PGC-1 alpha Activator ZLN005 Ameliorates Ischemia-Induced Neuronal Injury In Vitro and In Vivo, CELLULAR AND MOLECULAR NEUROBIOLOGY, 2018, 第 8 作者
（120） Function-Oriented Synthesis of Marine Phidianidine Derivatives as Potential PTP1B Inhibitors with Specific Selectivity, MARINE DRUGS, 2018, 第 5 作者
（121） AMPK regulates anaphase central spindle Length by phosphorylation of KIF4A, AMPK regulates anaphase central spindle Length by phosphorylation of KIF4A, 分子细胞生物学报：英文版, 2018, 第 4 作者
（122） Dysohonin A, a meroditerpenoid incorporating a 6,15,6-fused heterotricyclic ring system from Dysoxylum hongkongense, ORGANIC CHEMISTRY FRONTIERS, 2018, 第 4 作者
（123） AMPK regulates anaphase central spindle length by phosphorylation of KIF4A., J MOL CELL BIOL, 2018, 第 4 作者  通讯作者
（124） Development of Macrocyclic Peptides Containing Epoxyketone with Oral Availability as Proteasome Inhibitors, JOURNAL OF MEDICINAL CHEMISTRY, 2018, 第 10 作者
（125） A series of camptothecin prodrugs exhibit HDAC inhibition activity, BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 第 7 作者
（126） Supramolecular glyco-poly-cyclodextrin functionalized thin-layer manganese dioxide for targeted stimulus-responsive bioimaging, CHEMICAL COMMUNICATIONS, 2018, 第 8 作者  通讯作者
（127） 肝脏巨噬细胞在组织稳态和肝脏疾病中的功能探讨, The Roles of Hepatic Macrophages in-Tissue Homeostasis and Liver Diseases, 药学进展, 2018, 第 3 作者
（128） Acylated iridoid diglycosides from the cultivated endangered ornamental tree Gmelina hainanensis, PHYTOCHEMISTRY LETTERS, 2018, 第 8 作者
（129） Marine bis-gamma-pyrone polypropionates of onchidione family and their effects on the XBP1 gene expression, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 第 4 作者
（130） Structural Elucidation and Bioinspired Total Syntheses of Ascorbylated Diterpenoid Hongkonoids A-D, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 第 10 作者
（131） Cyclopeptide RA-V Inhibits Organ Enlargement and Tumorigenesis Induced by YAP Activation, CANCERS, 2018, 第 13 作者  通讯作者
（132） Novel Nitric Oxide Donors of Phenylsulfonylfuroxan and 3-Benzyl Coumarin Derivatives as Potent Antitumor Agents, ACS MEDICINAL CHEMISTRY LETTERS, 2018, 第 6 作者
（133） Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno3���,2���:3,4pyrido1,2-bisoquinoline and 5,8,12,12a-tetrahydro-6H-thieno2���,3���:4,5pyrido2,1-aisoquinoline derivatives as cellular activators of adenosine 5���-monophosphate-activated protein kinase (AMPK), BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 第 8 作者  通讯作者
（134） Dictyoptesterols A���C, ���22-24-oxo cholestane-type sterols with potent PTP1B inhibitory activity from the brown alga Dictyopteris undulata Holmes, FITOTERAPIA, 2018, 第 5 作者
（135） AMPK regulates anaphase central spindle Length by phosphorylation of KIF4A, AMPK regulates anaphase central spindle Length by phosphorylation of KIF4A, JOURNAL OF MOLECULAR CELL BIOLOGY, 2018, 第 4 作者  通讯作者
（136） Further New Diterpenoids as PTP1B Inhibitors from the Xisha Soft Coral Sinularia polydactyla, MARINE DRUGS, 2018, 第 4 作者
（137） Novel substituted pyrazolone derivatives as AMP- activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice, Novel substituted pyrazolone derivatives as AMP- activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice, 中国药理学报：英文版, 2018, 第 10 作者
（138） Structurally Diverse Sesquiterpenoids from the Endangered Ornamental Plant Michelia shiluensis, JOURNAL OF NATURAL PRODUCTS, 2018, 第 8 作者
（139） Design and optimization of 2,3-dihydrobenzob1,4dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles, BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 第 5 作者
（140） Discovery of thiophene-containing biaryl amide derivatives as novel glucagon receptor antagonists, CHEMICAL BIOLOGY & DRUG DESIGN, 2018, 第 1 作者
（141） Dictyoptesterols A-C, Delta(22)-24-oxo cholestane-type sterols with potent PTP1B inhibitory activity from the brown alga Dictyopteris undulata Holmes, FITOTERAPIA, 2018, 第 5 作者
（142） Novel spirocyclic tranylcypromine derivatives as lysine-specific demethylase 1 (LSD1) inhibitors, RSCADVANCES, 2018, 第 7 作者
（143） Design, synthesis and biological evaluation of thienopyrimidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 第 8 作者  通讯作者
（144） Supramolecular Polymer Dot Ensemble for Ratiometric Detection of Lectins and Targeted Delivery of Imaging Agents, ACS APPLIED MATERIALS & INTERFACES, 2017, 第 7 作者  通讯作者
（145） D-A-D fluorogenic probe for the rapid imaging of amyloid �� plaques invivo, DYES AND PIGMENTS, 2017, 第 5 作者
（146） Structural and Stereochemical Studies of Laurokamurols A-C, Uncommon Bis-sesquiterpenoids from the Chinese Red Alga Laurencia okamurai Yamada, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2017, 第 5 作者
（147） Isoprenylated phenolic compounds with PTP1B inhibition from Morus alba, FITOTERAPIA, 2017, 第 5 作者
（148） Camellianols A-G, Barrigenol-like Triterpenoids with PTP1B Inhibitory Effects from the Endangered Ornamental Plant Camellia crapnelliana, JOURNAL OF NATURAL PRODUCTS, 2017, 第 6 作者
（149） synthesisandcelldivisioncycle25bphosphataseandproteintyrosinephosphatase1binhibitoryactivityevaluationofnovel36disubstitutedtriazolothiadiazolederivatives, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2017, 第 9 作者  通讯作者
（150） Benzoc1,2,5thiadiazole derivatives: A new class of potent Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 第 11 作者
（151） Asymmetric Synthesis of Chiral ��-Substituted Mercaptoglycine Derivatives via ��-Sulfenylation of Ni(ll) Complex of Glycine and S-Substituted 4-Methylbenzenesulfonothioate, CHINESE JOURNAL OF CHEMISTRY, 2017, 第 1 作者
（152） Asymmetric Synthesis of Chiral a-Substituted Mercaptoglycine Derivatives via α-Sulfenylation of Ni(ll) Complex of Glycine and S-Substituted 4-Methylbenzenesulfonothioate, Asymmetric Synthesis of Chiral a-Substituted Mercaptoglycine Derivatives via ��-Sulfenylation of Ni(ll) Complex of Glycine and S-Substituted 4-Methylbenzenesulfonothioate, 中国化学：英文版, 2017, 第 1 作者
（153） An ultrasensitive fluorogenic probe for revealing the role of glutathione in chemotherapy resistance, CHEMICAL SCIENCE, 2017, 第 5 作者
（154） GPCR Activation and Endocytosis Induced by a 2D Material Agonist, ACS APPLIED MATERIALS & INTERFACES, 2017, 第 6 作者  通讯作者
（155） The metabolic ER stress sensor IRE1 alpha suppresses alternative activation of macrophages and impairs energy expenditure in obesity, NATURE IMMUNOLOGY, 2017, 第 13 作者
（156） Photoswitchable arene ruthenium and pentamethylcyclopentadienyl rhodium complexes containing o-sulfonamide azobenzene ligands: synthesis, characterization and cytotoxicity., J Organomet Chem, 2017, 第 1 作者  通讯作者
（157） Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno3���,2���:3,4pyrido1,2-bisoquinolines as novel adenosine 5���-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 第 10 作者  通讯作者
（158） Supramolecular assembly of fluorogenic glyco-dots from perylenediimide-based glycoclusters for targeted imaging of cancer cells, CHEMICAL COMMUNICATIONS, 2017, 第 6 作者  通讯作者
（159） 5-Alkylpyrrole-2-carboxaldehyde derivatives from the Chinese sponge Mycale lissochela and their PTP1B inhibitory activities, CHINESE CHEMICAL LETTERS, 2017, 第 6 作者
（160） Diterpenoids from the needles and twigs of the cultivated endangered pine Pinus kwangtungensis and their PTP1B inhibitory effects, PHYTOCHEMISTRY LETTERS, 2017, 第 7 作者
（161） Metabolic Regulation of Gene Expression by Histone Lysine beta-hydroxybutyrylation, FASEB JOURNAL, 2017, 第 22 作者
（162） Fluorescent glycoprobes: a sweet addition for improved sensing, CHEMICAL COMMUNICATIONS, 2017, 第 4 作者  通讯作者
（163） A Novel Sarsolenane Diterpene as a PTP1B Inhibitor from Hainan Soft Coral Sarcophyton trocheliophorum Marenzeller, CHINESE JOURNAL OF CHEMISTRY, 2017, 第 5 作者
（164） Asymmetric Synthesis of Chiral alpha-Substituted Mercaptoglycine Derivatives via alpha-Sulfenylation of Ni(II) Complex of Glycine and S-Substituted 4-Methylbenzenesulfonothioate, CHINESE JOURNAL OF CHEMISTRY, 2017, 第 1 作者
（165） Discovery of core-structurally novel PTP1B inhibitors with specific selectivity containing oxindole-fused spirotetrahydrofurochroman by one-pot reaction, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 第 5 作者
（166） The Landscape of Histone Modifications in a High-Fat Diet-Induced Obese (DIO) Mouse Model *, MOLECULAR & CELLULAR PROTEOMICS, 2017, 第 8 作者
（167） 新型3，6-二取代三唑并噻二唑衍生物的合成及细胞分裂周期25B磷酸酶和蛋白酪氨酸磷酸酶1B抑制活性研究, Synthesis and Cell Division Cycle 25B Phosphatase and Protein Tyrosine Phosphatase 1B Inhibitory Activity Evaluation of Novel 3,6-Disubstituted Triazolothiadiazole Derivatives, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2017, 第 9 作者  通讯作者
（168） Aglaiabbrevins A-D, New Prenylated Bibenzyls from the Leaves of Aglaia abbreviata with Potent PTP1B Inhibitory Activity, CHEMICAL & PHARMACEUTICAL BULLETIN, 2017, 第 6 作者
（169） Tying up tranylcypromine: Novel selective histone lysine specific demethylase 1 (LSD1) inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 第 8 作者
（170） Cucurbitane Glucosides from the Crude Extract of Siraitia grosvenorii with Moderate Effects on PGC-1 alpha Promoter Activity, JOURNAL OF NATURAL PRODUCTS, 2017, 第 10 作者
（171） Remote light-controlled intracellular target recognition by photochromic fluorescent glycoprobes, NATURE COMMUNICATIONS, 2017, 第 5 作者  通讯作者
（172） Graphene oxide-enhanced cytoskeleton imaging and mitosis tracking, CHEMICAL COMMUNICATIONS, 2017, 第 9 作者  通讯作者
（173） Concise synthesis and PTP1B inhibitory activity of (R)- and (S)-dihydroresorcylide, JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2017, 第 6 作者
（174） Aglaiabbrevins A-D, New Prenylated Bibenzyls from the Leaves of Aglaia abbreviata with Potent PTP1B Inhibitory Activity, CHEMICAL & PHARMACEUTICAL BULLETIN, 2017, 第 6 作者
（175） D-A-D fluorogenic probe for the rapid imaging of amyloid beta plaques in vivo, DYES AND PIGMENTS, 2017, 第 5 作者  通讯作者
（176） 5-Alkylpyrrole-2-carboxaldehyde derivatives from the Chinese sponge Mycale lissochela and their PTP1B inhibitory activities, CHINESE CHEMICAL LETTERS, 2017, 第 6 作者
（177） Exploration of novel piperazine or piperidine constructed non-covalent peptidyl derivatives as proteasome inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 第 14 作者  通讯作者
（178） Supramolecular core-glycoshell polythiophene nanodots for targeted imaging and photodynamic therapy, CHEMICAL COMMUNICATIONS, 2017, 第 4 作者  通讯作者
（179） Cephalotanins A-D, Four Norditerpenoids Represent Three Highly Rigid Carbon Skeletons from Cephalotaxus sinensis, CHEMISTRY-A EUROPEAN JOURNAL, 2016, 
（180） 石胆酸类似物的设计、合成及其蛋白酪氨酸磷酸酯酶1B抑制活性, Design, Synthesis of Lithocholic Acid Mimics and Their Inhibitory Activities against Protein Tyrosine Phosphatase 1B, 有机化学, 2016, 第 7 作者
（181） Rare Sesquiterpenoids from the Shed Trunk Barks of the Critically Endangered Plant Abies beshanzuensis and Their Bioactivities, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2016, 第 8 作者
（182） DESIGN, SYNTHESIS, IN VITRO ANTIPROLIFERATIVE ACTIVITY EVALUATION OF 2-ALICANOYLAMIDOTHIOPHENE-3-CARBOXAMIDE DERIVATIVES, HETEROCYCLES, 2016, 第 9 作者
（183） Diterpenoids from the shed trunk barks of the endangered plant Pinus dabeshanensis and their PTP1B inhibitory effects, RSC ADVANCES, 2016, 第 4 作者
（184） 吲哚丙基-1，3，4-噁二唑衍生物的合成及蛋白酪氨酸磷酸酯酶1B抑制活性研究, Synthesis and Protein-Tyrosine Phosphatase 1B Inhibitory Activity Evaluation of Indolepropyl Based 1,3,4-Oxadiazole Derivatives, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2016, 第 3 作者
（185） N-Oxyamide-linked glycoglycerolipid coated AuNP for receptor-targeting imaging and drug delivery, Chem Commun (Camb), 2016, 第 1 作者  通讯作者
（186） A supramolecular pyrenyl glycoside-coated 2D MoS2 composite electrode for selective cell capture, CHEMICAL COMMUNICATIONS, 2016, 第 5 作者  通讯作者
（187） Asymmetric Synthesis of Aromatic and Heteroaromatic alpha-Amino Acids Using a Recyclable Axially Chiral Ligand (vol 2016, pg 999, 2016), EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2016, 第 1 作者
（188） Staurosporine as an agonist for induction of GLUT4 translocation, identified by a pH-sensitive fluorescent IRAP-mOrange2 probe, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 第 5 作者
（189） Regulation of Ubiquitin-like with Plant Homeodomain and RING Finger Domain 1 (UHRF1) Protein Stability by Heat Shock Protein 90 Chaperone Machinery, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 第 7 作者  通讯作者
（190） Photoswitchable arene ruthenium and pentamethylcyclopentadienyl rhodium complexes containing o-sulfonamide azobenzene ligands: Synthesis, characterization and cytotoxicity, JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2016, 第 7 作者
（191） Design, Synthesis of Lithocholic Acid Mimics and Their Inhibitory Activities against Protein Tyrosine Phosphatase 1B, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2016, 第 7 作者
（192） Foldable glycoprobes capable of fluorogenic crosslinking of biomacromolecules, CHEMICAL SCIENCE, 2016, 第 5 作者  通讯作者
（193） Structure and Configuration of Phosphoeleganin, a Protein Tyrosine Phosphatase 1B Inhibitor from the Mediterranean Ascidian Sidnyum elegans, JOURNAL OF NATURAL PRODUCTS, 2016, 第 7 作者
（194） Identification of Bisindolylmaleimide IX as a potential agent to treat drug-resistant BCR-ABL positive leukemia, ONCOTARGET, 2016, 第 8 作者
（195） Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 第 7 作者
（196） Design and synthesis of new potent PTP1B inhibitors with the skeleton of 2-substituted imino-3-substituted-5-heteroarylidene-1,3-thiazolidine-4-one: Part I, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 第 10 作者  通讯作者
（197） Bioactive isoquinolinequinone alkaloids from the South China Sea nudibranch Jorunna funebris and its sponge-prey Xestospongia sp., FUTURE MEDICINAL CHEMISTRY, 2016, 第 6 作者
（198） Cipacinoids A-D, Four Limonoids with Spirocyclic Skeletons from Cipadessa cinerascens, ORGANIC LETTERS, 2016, 第 5 作者
（199） 芳酰胺类衍生物的合成及蛋白酪氨酸磷酸酶1B和含SH2结构域蛋白酪氨酸磷酸酶2抑制活性研究, Synthesis of Aromatic Amide Derivatives and Their Biological Evaluation against Protein Tyrosine Phosphatase 1B and Scr Homology-2 Domain Containing Protein Tyrosine Phosphatase-2, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2016, 第 7 作者
（200） Novel CHOP activator LGHO0168 induces necroptosis in A549 human lung cancer cells via ROS-mediated ER stress and NF-κB inhibition, Novel CHOP activator LGHO0168 induces necroptosis in A549 human lung cancer cells via ROS-mediated ER stress and NF-��B inhibition, 中国药理学报：英文版, 2016, 第 7 作者
（201） N-Oxyamide-linked glycoglycerolipid coated AuNPs for receptor-targeting imaging and drug delivery, CHEMICAL COMMUNICATIONS, 2016, 第 7 作者  通讯作者
（202） 芳酰胺类衍生物的合成及蛋白酪氨酸磷酸酶1B和含SH2结构域蛋白酪氨酸磷酸酶2抑制活性研究, Synthesis of Aromatic Amide Derivatives and Their Biological Evaluation against Protein Tyrosine Phosphatase 1B and Scr Homology-2 Domain Containing Protein Tyrosine Phosphatase-2, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2016, 第 7 作者
（203） Metabolic Regulation of Gene Expression by Histone Lysine beta-Hydroxybutyrylation, MOLECULAR CELL, 2016, 第 24 作者
（204） Design, synthesis and biological evaluation of novel non-covalent piperidine-containing peptidyl proteasome inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 第 11 作者  通讯作者
（205） Dysiherbols A-C and Dysideanone E, Cytotoxic and NF-kappa B Inhibitory Tetracyclic Meroterpenes from a Dysidea sp Marine Sponge, JOURNAL OF NATURAL PRODUCTS, 2016, 第 9 作者
（206） Design, synthesis, structure���activity relationships, and docking studies of pyrazole-containing derivatives as a novel series of potent glucagon receptor antagonists, BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 第 3 作者
（207） A novel GSK-3β inhibitor YQ138 prevents neuronal injury induced by glutamate and brain ischemia through activation of the Nrf2 signaling pathway, anovelgsk3inhibitoryq138preventsneuronalinjuryinducedbyglutamateandbrainischemiathroughactivationofthenrf2signalingpathway, ACTAPHARMACOLOGICASINICA, 2016, 第 13 作者
（208） 青钱柳叶化学成分及其PTP1B 抑制活性的研究, 中南药学, 2016, 第 5 作者
（209） Targeted fluorescence imaging enhanced by 2D materials: a comparison between 2D MoS2 and graphene oxide, CHEMICAL COMMUNICATIONS, 2016, 第 8 作者  通讯作者
（210） A novel GSK-3β inhibitor YQ138 prevents neuronal injury induced by glutamate and brain ischemia through activation of the Nrf2 signaling pathway, A novel GSK-3�� inhibitor YQ138 prevents neuronal injury induced by glutamate and brain ischemia through activation of the Nrf2 signaling pathway, 中国药理学报：英文版, 2016, 第 13 作者
（211） Targeted Intracellular Production of Reactive Oxygen Species by a 2D Molybdenum Disulfide Glycosheet, ADVANCED MATERIALS, 2016, 第 4 作者  通讯作者
（212） New alkaloids from Daphniphyllum himalense, RSC ADVANCES, 2016, 第 5 作者
（213） Plasma levels of growth differentiation factor-15 are associated with myocardial injury in patients undergoing off-pump coronary artery bypass grafting, SCIENTIFIC REPORTS, 2016, 第 8 作者
（214） Carbohydrate CuAAC click chemistry for therapy and diagnosis, CARBOHYDRATE RESEARCH, 2016, 第 4 作者  通讯作者
（215） Eucarobustols A-I, Conjugates of Sesquiterpenoids and Acylphloroglucinols from Eucalyptus robusta, JOURNAL OF NATURAL PRODUCTS, 2016, 第 7 作者  通讯作者
（216） Novel CHOP activator LGH00168 induces necroptosis in A549 human lung cancer cells via ROS-mediated ER stress and NF-kappa B inhibition, ACTA PHARMACOLOGICA SINICA, 2016, 第 7 作者
（217） Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 第 9 作者  通讯作者
（218） Targeted multimodal theranostics via biorecognition controlled aggregation of metallic nanoparticle composites, CHEMICAL SCIENCE, 2016, 第 3 作者  通讯作者
（219） Asymmetric Synthesis of Aromatic and Heteroaromatic -Amino Acids Using a Recyclable Axially Chiral Ligand, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2016, 第 1 作者
（220） Design, synthesis and biological evaluation of pyrazol-furan carboxamide analogues as novel Akt kinase inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 第 8 作者
（221） A novel GSK-3 beta inhibitor YQ138 prevents neuronal injury induced by glutamate and brain ischemia through activation of the Nrf2 signaling pathway, ACTA PHARMACOLOGICA SINICA, 2016, 第 13 作者  通讯作者
（222） Discovery and Rational Design of Natural-Product-Derived 2-Phenyl-3,4-dihydro-2H-benzofchromen-3-amine Analogs as Novel and Potent Dipeptidyl Peptidase 4 (DPP-4) Inhibitors for the Treatment of Type 2 Diabetes, JOURNAL OF MEDICINAL CHEMISTRY, 2016, 第 19 作者
（223） Development of a novel H2S and GSH detection cocktail for fluorescence imaging, RSC ADVANCES, 2016, 第 5 作者
（224） Macdentichalcone, a unique polycyclic dimeric chalcone from Macaranga denticulata, TETRAHEDRON LETTERS, 2016, 第 6 作者
（225） Novel CHOP activator LGH00168 induces necroptosis in A549 human lung cancer cells via ROS-mediated ER stress and NF-kB inhibition, ACTA PHARMACOLOGICA SINICA, 2016, 第 7 作者
（226） Himalensines A and B, Alkaloids from Daphniphyllum himalense, ORGANIC LETTERS, 2016, 第 4 作者
（227） A new bioactive steroidal ketone from the South China Sea sponge Xestospongia testudinaria, JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2016, 第 4 作者
（228） miR-182 Regulates Metabolic Homeostasis by Modulating Glucose Utilization in Muscle, CELL REPORTS, 2016, 第 22 作者
（229） Interlocked supramolecular glycoconjugated polymers for receptor-targeting theranostics, CHEMICAL COMMUNICATIONS, 2016, 第 7 作者  通讯作者
（230） A near-infrared fluorescent probe for rapid detection of hydrogen peroxide in living cells, TETRAHEDRON, 2015, 第 6 作者  通讯作者
（231） Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe (vol 51, pg 11852, 2015), CHEMICAL COMMUNICATIONS, 2015, 第 7 作者
（232） Synthesis of Novel 3-aryl-1-oxa-2,8-diazaspiro4.5dec-2-ene Derivatives and Their Biological Evaluation Against Protein Tyrosine Phosphatase 1B, CHEMICAL BIOLOGY & DRUG DESIGN, 2015, 第 6 作者
（233） Quick Serological Detection of a Cancer Biomarker with an Agglutinated Supramolecular Glycoprobe, ANALYTICAL CHEMISTRY, 2015, 第 6 作者
（234） Chlorabietols A-C, Phloroglucinol-Diterpene Adducts from the Chloranthaceae Plant Chloranthus oldhamii, JOURNAL OF ORGANIC CHEMISTRY, 2015, 第 7 作者  通讯作者
（235） New Isoprenylated Phenolic Compounds from Morus laevigata, CHEMISTRY & BIODIVERSITY, 2015, 第 7 作者
（236） Divergent Synthesis of Multisubstituted Tetrahydrofurans and Pyrrolidines via Intramolecular Aldol-type Trapping of Onium Ylide Intermediates, CHEMISTRYAEUROPEANJOURNAL, 2015, 第 4 作者
（237） Two Enantiomeric Pairs of Meroterpenoids from Rhododendron capitatum, ORGANIC LETTERS, 2015, 第 5 作者
（238） Physalin B not only inhibits the ubiquitin-proteasome pathway but also induces incomplete autophagic response in human colon cancer cells in vitro, ACTA PHARMACOLOGICA SINICA, 2015, 第 3 作者
（239） Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 第 7 作者
（240） Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKK beta-dependent AMPK activation, BRAIN BEHAVIOR AND IMMUNITY, 2015, 第 9 作者
（241） 2-(3-Be nzoylth iou reido)-4,5,6,7-tet ra hydro be n zo b thiophene-3-carboxylic acid ameliorates metabolic disorders in high-fat diet-fed mice, 2-(3-Be nzoylth iou reido)-4,5,6,7-tet ra hydro be n zo b thiophene-3-carboxylic acid ameliorates metabolic disorders in high-fat diet-fed mice, 中国药理学报：英文版, 2015, 第 12 作者
（242） Diels���Alder adducts with PTP1B inhibition from Morus notabilis, PHYTOCHEMISTRY, 2015, 第 6 作者
（243） Synthesis and biological evaluation of 3-(1,2,4triazolo 4,3-apyridin-3-yl)-4-(indol-3-yl)-maleimides as potent, selective GSK-3 beta inhibitors and neuroprotective agents, BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 第 14 作者
（244） 以中链脂肪酸受体GPR84为靶点的药物高通量筛选模型的建立和应用, Establishment and Application of a High-throughput-screening Model for Medium-chain Fatty Acid-sensing Receptor GPR84, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2015, 第 3 作者
（245） Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKK��-dependent AMPK activation, BRAIN BEHAVIOR AND IMMUNITY, 2015, 第 9 作者
（246） Bioactive sesquiterpene quinols and quinones from the marine sponge Dysidea avara, RSC ADVANCES, 2015, 第 11 作者
（247） Terpenoids and Steroids from Euphorbia hypericifolia, NATURAL PRODUCT COMMUNICATIONS, 2015, 第 4 作者
（248） Selective fluorogenic imaging of hepatocellular H2S by a galactosyl azidonaphthalimide probe, CHEMICAL COMMUNICATIONS, 2015, 第 4 作者  通讯作者
（249） Protein Kinase A Rescues Microtubule Affinity-regulating Kinase 2-induced Microtubule Instability and Neurite Disruption by Phosphorylating Serine 409, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 第 16 作者  通讯作者
（250） PTP1B inhibitors from stems of Angelica keiskei (Ashitaba), BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 第 8 作者
（251） Disruption of the unfolded protein response (UPR) by lead compound selectively suppresses cancer cell growth, CANCER LETTERS, 2015, 第 14 作者
（252） 以中链脂肪酸受体GPR84为靶点的药物高通量筛选模型的建立和应用, Establishment and Application of a High-throughput-screening Model for Medium-chain Fatty Acid-sensing Receptor GPR84, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2015, 第 3 作者
（253） Synthesis of novel 3-aryl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene derivatives and their biological evaluation against PTP1B, Chem Biol Drug Des, 2015, 第 1 作者  通讯作者
（254） Receptor-targeting fluorescence imaging and theranostics using a graphene oxide based supramolecular glycocomposite, JOURNALOFMATERIALSCHEMISTRYB, 2015, 第 6 作者
（255） Probing disease-related proteins with fluorogenic composite materials, CHEMICAL SOCIETY REVIEWS, 2015, 第 4 作者  通讯作者
（256） Synthesis and Evaluation of 3-(furo2,3-bpyridin-3-yl)-4-(1H-indol-3-yl)-maleimides as Novel GSK-3 Inhibitors and Anti-Ischemic Agents, CHEMICAL BIOLOGY & DRUG DESIGN, 2015, 第 13 作者
（257） Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 第 11 作者
（258） Bioactive constituents from the green alga Caulerpa racemosa, BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 第 4 作者
（259） Development of a Novel Phosphorylated AMPK Protection Assay for High-Throughput Screening Using TR-FRET Assay, JOURNAL OF BIOMOLECULAR SCREENING, 2015, 第 4 作者
（260） Mixed galactolipid anomers accentuate apoptosis of multiple myeloma cells by inducing DNA damage, CARBOHYDRATE RESEARCH, 2015, 第 5 作者
（261） Synthesis and biological evaluation of 3-(1,2,4triazolo4,3-apyridin-3-yl)-4-(indol-3-yl)-maleimides as potent, selective GSK-3�� inhibitors and neuroprotective agents, BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 第 14 作者
（262） Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe, CHEMICAL COMMUNICATIONS, 2015, 第 7 作者
（263） 3，5，6-三取代-1，2，4-三嗪衍生物合成、表征及生物活性, Synthesis, Characterization and Biological Activities of 3,5,6-Trisubstituted-1,2,4-triazine Derivatives, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2015, 第 8 作者
（264） 3，5，6-三取代-1，2，4-三嗪衍生物合成、表征及生物活性, Synthesis, Characterization and Biological Activities of 3,5,6-Trisubstituted-1,2,4-triazine Derivatives, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2015, 第 8 作者
（265） 新型2，5-二取代-1，3，4-噻二唑衍生物的合成与生物活性, Synthesis and Biological Activities of Novel 2,5-Disubstituted-1,3,4-thiadiazole Derivatives, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2015, 第 8 作者
（266） Structural diversity of terpenoids in the soft coral Sinularia flexibilis, evidenced by a collection from the South China Sea, RSC ADVANCES, 2015, 第 2 作者
（267） Galiellalactone analogs and their possible precursors from Sarcosomataceae, FITOTERAPIA, 2015, 第 7 作者
（268） Dynamic tracking of pathogenic receptor expression of live cells using pyrenyl glycoanthraquinone-decorated grapheme electrodes., Chem Sci, 2015, 第 1 作者  通讯作者
（269） NIR absorbing DICPO derivatives applied to wide range of pH and detection of glutathione in tumor, TETRAHEDRON, 2015, 第 6 作者  通讯作者
（270） Brominated polyunsaturated lipids with protein tyrosine phosphatase-1B inhibitory activity from Chinese marine sponge Xestospongia testudinaria, JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2015, 第 6 作者
（271） Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction, TOXICOLOGY AND APPLIED PHARMACOLOGY, 2015, 第 9 作者
（272） 重大疾病导向的G蛋白偶联受体研究, Research of G-protein Coupled Receptor Related to Important Human Diseases, 中国基础科学, 2015, 第 3 作者
（273） Isoprenylated Flavonoids with PTP1B Inhibition from Ficus tikoua, NATURAL PRODUCT COMMUNICATIONS, 2015, 第 6 作者
（274） 2-(3-Benzoylthioureido)-4,5,6,7-tetrahydrobenzobthiophene-3-carboxylic acid ameliorates metabolic disorders in high-fat diet-fed mice, ACTA PHARMACOLOGICA SINICA, 2015, 第 12 作者
（275） Functional Role of Histidine in the Conserved His-x-Asp Motif in the Catalytic Core of Protein Kinases, SCIENTIFIC REPORTS, 2015, 第 10 作者
（276） New laurane-type sesquiterpenoids from the Chinese red alga Laurencia okamurai Yamada, JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2015, 第 3 作者
（277） 新型2，5-二取代-1，3，4-噻二唑衍生物的合成与生物活性, Synthesis and Biological Activities of Novel 2,5-Disubstituted-1,3,4-thiadiazole Derivatives, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2015, 第 8 作者
（278） Design and synthesis of novel 1,2-dithiolan-4-yl benzoate derivatives as PTP1B inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 第 7 作者  通讯作者
（279） Hydroxylated Daphniphyllum Alkaloids from Daphniphyllum himalense, JOURNAL OF NATURAL PRODUCTS, 2015, 第 4 作者
（280） BERBERINE ANALOGUES: PROGRESS TOWARDS VERSATILE APPLICATIONS, HETEROCYCLES, 2015, 第 4 作者
（281） Dynamic tracking of pathogenic receptor expression of live cells using pyrenyl glycoanthraquinone-decorated graphene electrodes, CHEMICAL SCIENCE, 2015, 第 4 作者
（282） Synthesis and biological evaluation of novel 2,3-pyrazole ring-substituted-4,4-dimethyl lithocholic acid derivatives as selective protein tyrosine phosphatase 1B (PTP1B) inhibitors with cellular efficacy, RSC ADVANCES, 2015, 第 7 作者
（283） Design, synthesis and biological evaluation of novel tripeptidyl epoxyketone derivatives constructed from beta-amino acid as proteasome inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 第 6 作者  通讯作者
（284） Fluorogenic Resveratrol-Confined Graphene Oxide For Economic and Rapid Detection Of Alzheimer's Disease, ACS APPLIED MATERIALS & INTERFACES, 2014, 
（285） 4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B (vol 22, pg 3670, 2014), BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 第 6 作者  通讯作者
（286） Chaetoglobosin Y, a new cytochalasan from Chaetomium globosum, FITOTERAPIA, 2014, 第 8 作者
（287） Discovery, synthesis, and structure���activity relationships of 20(S)-protopanaxadiol (PPD) derivatives as a novel class of AMPK��2��1��1 activators, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 第 5 作者
（288） One-Step Click Engineering Considerably Ameliorates the Practicality of an Unqualified Rhodamine Probe, ACS APPLIED MATERIALS & INTERFACES, 2014, 
（289） A ���Clicked' Tetrameric Hydroxamic Acid Glycopeptidomimetic Antagonizes Sugar-Lectin Interactions On The Cellular Level, SCIENTIFIC REPORTS, 2014, 
（290） 新型咪唑2，1-b1，3，4噻二唑衍生物的合成及Cdc25B 抑制活性, Synthesis and Cdc25B Inhibition Activity of Novel Imidazo2,1-b1,3,4thiadiazole Derivatives, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2014, 第 8 作者
（291） Curcusone D, a novel ubiquitin-proteasome pathway inhibitor via ROS-induced DUB inhibition, is synergistic with bortezomib against multiple myeloma cell growth, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2014, 第 12 作者
（292） Involvement of transcription factor XBP1s in the resistance of HDAC6 inhibitor Tubastatin A to superoxidation via acetylation-mediated proteasomal degradation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 第 6 作者
（293） Discovery of a novel inhibitor of NAD(P) + -dependent malic enzyme (ME2) by high-throughput screening, ACTA PHARMACOLOGICA SINICA, 2014, 第 7 作者
（294） Dysidaminones A-M, cytotoxic and NF-kappa B inhibitory sesquiterpene aminoquinones from the South China Sea sponge Dysidea fragilis, RSC ADVANCES, 2014, 第 5 作者
（295） Design, synthesis and biological evaluation of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopentabpyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 第 10 作者  通讯作者
（296） Guignardins A-F, spirodioxynaphthalenes from the endophytic fungus Guignardia sp KcF8 as a new class of PTP1B and SIRT1 inhibitors, TETRAHEDRON, 2014, 第 9 作者  通讯作者
（297） Streptospirodienoic acids A and B, 6,6-spiroketal polyketides from Streptomyces sp., RSC ADVANCES, 2014, 第 7 作者
（298） New triterpenoids with protein tyrosine phosphatase 1B inhibition from Cedrela odorata, JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2014, 第 6 作者
（299） Discovery, synthesis, and structure activity relationships of 20(S)-protopanaxadiol (PPD) derivatives as a novel class of AMPK alpha 2 beta 1 gamma 1 activators, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 第 5 作者
（300） Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors, ORGANIC & BIOMOLECULAR CHEMISTRY, 2014, 第 7 作者
（301） Three pairs of variecolortide enantiomers from Eurotium sp with caspase-3 inhibitory activity, FITOTERAPIA, 2014, 第 7 作者
（302） Synthesis and biological evaluation of novel thiadiazole amides as potent Cdc25B and PTP1B inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 第 8 作者
（303） Design, synthesis, and biological evaluation of ring-opened bengamide analogs as anticancer agents, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 第 4 作者
（304） Hepatoma-selective imaging of heavy metal ions using a 'clicked' galactosylrhodamine probe, CHEMICAL COMMUNICATIONS, 2014, 
（305） Hainanerectamines A���C, Alkaloids from the Hainan Sponge Hyrtios erecta, MARINE DRUGS, 2014, 第 5 作者
（306） Identification of a new bis-amino acid glycoside selectively toxic to multiple myeloma cells, CARBOHYDRATE RESEARCH, 2014, 第 4 作者
（307） 4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B, BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 第 6 作者  通讯作者
（308） Design, synthesis and biological evaluation of 4-anilinothieno2,3-dpyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 第 8 作者  通讯作者
（309） Regio- and Diastereoselective Construction of alpha-Hydroxy-delta-amino Ester Derivatives via 1,4-Conjugate Addition of beta,gamma-Unsaturated N-Sulfonylimines, JOURNAL OF ORGANIC CHEMISTRY, 2014, 第 8 作者
（310） Substitution Pattern Reverses the Fluorescence Response of Coumarin Glycoligands upon Coordination with Silver (I), SCIENTIFIC REPORTS, 2014, 第 9 作者
（311） Four Phragmalin Orthoesters from the Chinese Mangrove Xylocarpus granatum, PLANTA MEDICA, 2014, 第 6 作者
（312） Synthesis and structure���activity relationship of non-phosphorus-based fructose-1,6-bisphosphatase inhibitors: 2,5-Diphenyl-1,3,4-oxadiazoles, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 第 8 作者
（313） Target-Specific Imaging of Transmembrane Receptors Using Quinonyl Glycosides Functionalized Quantum Dots, ANALYTICAL CHEMISTRY, 2014, 
（314） Design, Synthesis and Biological Evaluation of Peptidyl Epoxyketone Proteasome Inhibitors Composed of beta-amino Acids, CHEMICAL BIOLOGY & DRUG DESIGN, 2014, 第 7 作者
（315） Azoxystrobin, a mitochondrial complex III Q(o) site inhibitor, exerts beneficial metabolic effects in vivo and in vitro, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2014, 第 9 作者
（316） Potent and Orally Efficacious Bisthiazole-Based HistoneDeacetylase Inhibitors, ACS MEDICINAL CHEMISTRY LETTERS, 2014, 第 5 作者  通讯作者
（317） 新型咪唑2，1-b1，3，4噻二唑衍生物的合成及Cdc25B 抑制活性, Synthesis and Cdc25B Inhibition Activity of Novel Imidazo2,1-b1,3,4thiadiazole Derivatives, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2014, 第 8 作者
（318） Design, synthesis and biological evaluation of hetero-aromatic moieties substituted pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 第 9 作者
（319） Sarsolenane and Capnosane Diterpenes from the Hainan Soft Coral Sarcophyton trocheliophorum Marenzeller as PTP1B Inhibitors, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2014, 第 5 作者
（320） (R)-3-Amino-1-((3aS,7aS)-octahydro-1H-indol-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one derivatives as potent inhibitors of dipeptidyl peptidase-4: Design, synthesis, biological evaluation, and molecular modeling, BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 第 8 作者  通讯作者
（321） Synthesis and biological evaluation of novel bis-aromatic amides as novel PTP1B inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 第 11 作者
（322） 死亡相关凋亡诱导蛋白激酶2（DRAK2）研究进展, 生命科学, 2014, 第 5 作者
（323） Racemosin C, a novel minor bisindole alkaloid with protein tyrosine phosphatase-1B inhibitory activity from the green alga Caulerpa racemosa, JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2014, 第 4 作者
（324） Design, synthesis and biological evaluation of 4 '-demethyl-4-deoxypodophyllotoxin derivatives as novel tubulin and histone deacetylase dual inhibitors, RSC ADVANCES, 2014, 第 6 作者
（325） Hepatic IRE1 alpha regulates fasting-induced metabolic adaptive programs through the XBP1s-PPAR alpha axis signalling, NATURE COMMUNICATIONS, 2014, 第 13 作者
（326） Cembrane diterpenoids from the soft coral Sarcophyton trocheliophorum Marenzeller as a new class of PTP1B inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 第 3 作者
（327） 3，6-二取代-1，2，4-三嗪衍生物的微波辅助合成及生物活性, Microwave-Assisted Synthesis and Biological Activities of 3,6-disubstituted-1,2,4-Triazine Derivatives, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2013, 第 8 作者
（328） Revisit of a dipropargyl rhodamine probe reveals its alternative ion sensitivity in both a solution and live cells, ANALYST, 2013, 第 6 作者
（329） Design, Synthesis, Structure-Activity Relationships, and Docking Studies of 1-(gamma-1,2,3-Triazol Substituted Prolyl)-(S)-3,3-Difluoropyrrolidines as a Novel Series of Potent and Selective Dipeptidyl Peptidase-4 Inhibitors, CHEMICAL BIOLOGY & DRUG DESIGN, 2013, 第 7 作者  通讯作者
（330） Berberine combined with 2-deoxy-D-glucose synergistically enhances cancer cell proliferation inhibition via energy depletion and unfolded protein response disruption, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2013, 第 5 作者
（331） Design and Synthesis of 4-(2,4,5-Trifluorophenyl)butane-1,3-diamines as Dipeptidyl PeptidaseIV Inhibitors, CHEMMEDCHEM, 2013, 第 9 作者  通讯作者
（332） Astragaloside II triggers T cell activation through regulation of CD45 protein tyrosine phosphatase activity, ACTA PHARMACOLOGICA SINICA, 2013, 第 9 作者
（333） The Design and Synthesis of a New Class of RTK/HDAC Dual-Targeted Inhibitors, MOLECULES, 2013, 第 4 作者
（334） Microwave-Assisted Synthesis and Biological Activities of 3,6-Disubstituted-1,2,4-triazine Derivatives, CHINESEJOURNALOFORGANICCHEMISTRY, 2013, 第 8 作者
（335） Unprecedented Diterpenoids as a PTP1B Inhibitor from the Hainan Soft Coral Sarcophyton trocheliophorum Marenzeller, ORGANIC LETTERS, 2013, 第 5 作者
（336） Novel Small-Molecule AMP-Activated Protein Kinase Allosteric Activator with Beneficial Effects in db/db Mice, PLOS ONE, 2013, 第 13 作者
（337） Novel Small-Molecule PGC-1 alpha Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice, DIABETES, 2013, 第 12 作者  通讯作者
（338） Synthesis and biological evaluation of novel benzyl-substituted (S)-phenylalanine derivatives as potent dipeptidyl peptidase 4 inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 第 6 作者
（339） Fluevirosines A-C: a biogenesis inspired example in the discovery of new bioactive scaffolds from Flueggea virosa., ORGANIC LETTERS, 2013, 第 6 作者
（340） 从小檗碱到新型线粒体功能调节剂改善代谢综合症（英文）, 2013, 第 1 作者
（341） Synthesis and Biological Evaluation of Furan-chalcone Derivatives as Protein Tyrosine Phosphatase Inhibitors, BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2013, 第 6 作者  通讯作者
（342） Astragaloside ��� triggers T cell activation through regulation of CD45 protein tyrosine phosphatase activity, ACTA PHARMACOLOGICA SINICA, 2013, 第 9 作者
（343） Development of Novel Alkene Oxindole Derivatives AsOrally Efficacious AMP-Activated Protein Kinase Activators, ACS MEDICINAL CHEMISTRY LETTERS, 2013, 第 11 作者
（344） A specific cholesterol metabolic pathway is established in a subset of HCCs for tumor growth, JOURNAL OF MOLECULAR CELL BIOLOGY, 2013, 第 12 作者
（345） Synthesis and PTP1B Inhibitory Activity of (E)-1-Substitutedphenyl-3-(4-((E)-(2-(4-phenylthiazol-2-yl)hydrazono)methyl)pheny1)-prop-2-en-1-ones, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2013, 第 7 作者
（346） Characterization of a novel curcumin analog P1 as potent inhibitor of the NF-kB signaling pathway with distinct mechanisms, ACTA PHARMACOLOGICA SINICA, 2013, 第 4 作者
（347） Capturing intercellular sugar-mediated ligand-receptor recognitions via a simple yet highly biospecific interfacial system, SCIENTIFIC REPORTS, 2013, 第 9 作者
（348） Bioactive polyhydroxylated steroids from the Hainan soft coral Sinularia depressa Tixier-Durivault, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 第 5 作者
（349） 中国南海总状蕨藻的脂肪酸类化学成分和生物活性研究, 中国海洋药物, 2013, 第 2 作者
（350） The discovery and optimization of novel dual inhibitors of topoisomerase ii and histone deacetylase, BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 第 9 作者
（351） Click Synthesis of Triazolyl Phenylalaninyl and Tyrosinyl Derivatives as New Protein Tyrosine Phosphatase Inhibitors, JOURNAL OF HETEROCYCLIC CHEMISTRY, 2013, 第 4 作者  通讯作者
（352） Characterization of a novel curcumin analog P1 as potent inhibitor of the NF-kappa B signaling pathway with distinct mechanisms, ACTA PHARMACOLOGICA SINICA, 2013, 第 4 作者
（353） Design, synthesis, and biological evaluation of novel 2-ethyl-5-phenylthiazole-4-carboxamide derivatives as protein tyrosine phosphatase 1B inhibitors with improved cellular efficacy, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 第 8 作者
（354） New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells, MARINE DRUGS, 2013, 第 5 作者
（355） The first synthesis of natural disulfide bruguiesulfurol and biological evaluation of its derivatives as a novel scaffold for PTP1B inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 第 7 作者
（356） Synthesis and in vitro cytotoxic evaluation of novel -(3,4,5-trimethoxyphenyl)pyridin-2()-one derivatives, MOLECULAR DIVERSITY, 2013, 第 4 作者
（357） The discovery of colchicine-SAHA hybrids as a new class of antitumor agents., BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 第 7 作者
（358） Synthesis and characterization of 5,7-dihydroxyflavanone derivatives as novel protein tyrosine phosphatase 1B inhibitors, JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2013, 第 6 作者
（359） Fluorogenic Probing of Specific Recognitions between Sugar Ligands and Glycoprotein Receptors on Cancer Cells by an Economic Graphene Nanocomposite, ADVANCED MATERIALS, 2013, 第 9 作者
（360） Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice, TOXICOLOGY AND APPLIED PHARMACOLOGY, 2013, 第 15 作者
（361） Dysidavarones A-D, new sesquiterpene quinones from the marine sponge Dysidea avara., ORGANIC LETTERS, 2012, 第 7 作者
（362） Synthesis and Anti-tumor Activity Evaluation of Alkyl Heterocyclyl Disulfides, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2012, 第 4 作者
（363） New Azaphilones and Chlorinated Phenolic Glycosides from Chaetomium elatum with Caspase-3 Inhibitory Activity, PLANTA MEDICA, 2012, 第 6 作者
（364） 含3，4-二氢-2（1H）-喹啉酮结构查尔酮衍生物的合成及蛋白酪氨酸磷酸酯酶1B抑制活性研究, Synthesis and Protein Tyrosine Phosphatase 1B Inhibitory Activity of Novel Chalcone Derivatives Containing 3,4-Dihydroquinolin-2(1H)-one Moiety, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2012, 第 6 作者
（365） A novel class of small-molecule caspase-3 inhibitors prepared by multicomponent reactions, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 第 6 作者
（366） Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 第 6 作者
（367） Discovery and optimization of 2,4-diaminoquinazoline derivatives as a new class of potent dengue virus inhibitors., JOURNAL OF MEDICINAL CHEMISTRY, 2012, 第 10 作者
（368） The anomeric mixture of some O-galactolipid derivatives is more toxic against cancer cells than either anomer alone, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 第 6 作者
（369） Novel microtubule-targeted agent 6-chloro-4- (methoxyphenyl) coumarin induces G2-M arrest and apoptosis in HeLa cells, Novel microtubule-targeted agent 6-chloro-4- (methoxyphenyl) coumarin induces G2-M arrest and apoptosis in HeLa cells, 中国药理学报：英文版, 2012, 
（370） Discovering Novel alpha-aminoacyl-Containing Proline Derivatives with Potent and Selective Inhibitory Activity Against Dipeptidyl Peptidase IV: Design, Synthesis, Biological Evaluation, and Molecular Modeling, CHEMICAL BIOLOGY & DRUG DESIGN, 2012, 第 6 作者
（371） Synthesis and Biological Evaluation of 2,4,6-Trihydroxychalcone Derivatives as Novel Protein Tyrosine Phosphatase 1B Inhibitors, CHEMICAL BIOLOGY & DRUG DESIGN, 2012, 第 5 作者  通讯作者
（372） Discovery and StructuralModification of 1-Phenyl-3-(1-phenylethyl)urea Derivatives as Inhibitorsof Complement, ACS MEDICINAL CHEMISTRY LETTERS, 2012, 第 7 作者
（373） Novel microtubule-targeted agent 6-chloro-4-(methoxyphenyl) coumarin induces G 2 -M arrest and apoptosis in HeLa cells, ACTA PHARMACOLOGICA SINICA, 2012, 第 5 作者
（374） SYNTHESIS AND BIOLOGICAL EVALUATION OF OLEANOLIC ACID DERIVATIVES AS NOVEL INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B, HETEROCYCLES, 2012, 第 7 作者
（375） Quantitative Proteomic Analysis of Membrane Proteins Involved in Astroglial Differentiation of Neural Stem Cells by SILAC Labeling Coupled with LC-MS/MS, JOURNAL OF PROTEOME RESEARCH, 2012, 第 5 作者
（376） Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 第 9 作者
（377） 烷基杂环芳基二硫醚类化合物的合成及抗癌活性研究, Synthesis and Anti-tumor Activity Evaluation of Alkyl Heterocyclyl Disulfides, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2012, 第 4 作者
（378） Synthesis and Biological Evaluation of Heterocyclic Ring-substituted Chalcone Derivatives as Novel Inhibitors of Protein Tyrosine Phosphatase 1B, BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2012, 第 6 作者  通讯作者
（379） DESIGN, SYNTHESIS AND BIOLOGICAL ACTIVITY EVALUATION OF 2-MERCAPTO-4(3H)-QUINAZOLINONE DERIVATIVES AS NOVEL INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B, HETEROCYCLES, 2012, 第 7 作者
（380） Absolute configurations of integracins A, B, and 15 '-dehydroxy-integracin B, CHIRALITY, 2012, 第 3 作者
（381） A Role for Protein Inhibitor of Activated STAT1 (PIAS1) in Lipogenic Regulation through SUMOylation-independent Suppression of Liver X Receptors, JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 第 12 作者
（382） BMS309403 Stimulates Glucose Uptake in Myotubes through Activation of AMP-Activated Protein Kinase, PLOS ONE, 2012, 第 13 作者
（383） DESIGN, SYNTHESIS AND BIOLOGICAL ACTIVITY EVALUATION OF 2,5-DIPHENYL-1,3,4-OXADIAZOLE DERIVATIVES AS NOVEL INHIBITORS OF FRUCTOSE-1,6-BISPHOSPHATASE, HETEROCYCLES, 2012, 第 9 作者
（384） Structural and stereochemical studies of five new pregnane steroids from the stem bark of Toona ciliata var. pubescens, STEROIDS, 2011, 第 6 作者  通讯作者
（385） Discovering the distinct inhibitory effects between C4-epimeric glycosyl amino acids: new insight into the development of protein tyrosine phosphatase inhibitors, GLYCOCONJUGATE JOURNAL, 2011, 第 8 作者
（386） 海洋放线菌Micromonospora sp.（M2DG17）细胞毒活性成分研究, Studies on the cytotoxic constituents from marine actinomycete Micromonospora sp.(M2DG17), 中国海洋药物, 2011, 第 6 作者
（387） Protolimonoids and norlimonoids from the stem bark of Toona ciliata var. pubescens, ORGANIC & BIOMOLECULAR CHEMISTRY, 2011, 第 6 作者
（388） ���Click��� to bidentate bis-triazolyl sugar derivatives with promising biological and optical features, TETRAHEDRON LETTERS, 2011, 第 7 作者  通讯作者
（389） Design, Synthesis, and Biological Evaluation of Ring-Opened Bengamide Analogues, CHEMMEDCHEM, 2011, 第 6 作者
（390） Structural insights into the homology and differences between mouse protein tyrosine phosphatase-sigma and human protein tyrosine phosphatase-sigma, Structural insights into the homology and differences between mouse protein tyrosine phosphatase-sigma and human protein tyrosine phosphatase-sigma, 生物化学与生物物理学报：英文版, 2011, 第 6 作者
（391） A unique and rapid approach toward the efficient development of novel protein tyrosine phosphatase (PTP) inhibitors based on ���clicked��� pseudo-glycopeptides, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 第 9 作者
（392） 基于四氢喹啉酸骈环戊烯骨架的蛋白酪氨酸磷酸酶1b抑制剂的设计合成及构效关系, Discovery and Structure-activity Relationships of Tetrahydro-3H-cyclopentacquinolines Scaffold-based Potential PTP1B Inhibitors, 高等学校化学学报, 2011, 第 7 作者
（393） 5 '-AMP-activated protein kinase (AMPK) regulates progesterone receptor transcriptional activity in breast cancer cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 第 7 作者
（394） Preparation of triazole-linked glycosylated alpha-ketocarboxylic acid derivatives as new PTP1B inhibitors, CARBOHYDRATE RESEARCH, 2011, 第 8 作者
（395） Synthesis of (Glycopyranosyl-triazolyl)-purines and Their Inhibitory Activities against Protein Tyrosine Phosphatase 1B (PTP1B), CHEMISTRY & BIODIVERSITY, 2011, 第 7 作者
（396） Synthesis and biological evaluation of piperamide analogues as HDAC inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 第 6 作者  通讯作者
（397） Synthesis and biological evaluation of (��)-3-(2-(2-fluorobenzyloxy) naphthalen-6-yl)-2-aminopropanoic acid derivatives as novel PTP1B inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 第 8 作者
（398） Paracaseolide A, First alpha-Alkylbutenolide Dimer with an Unusual Tetraquinane Oxa-Cage Bislactone Skeleton from Chinese Mangrove Sonneratia paracaseolaris, ORGANIC LETTERS, 2011, 第 3 作者
（399） Click to a focused library of benzyl 6-triazolo(hydroxy)benzoic glucosides: Novel construction of PTP1B inhibitors on a sugar scaffold, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 第 8 作者
（400） H-1 and C-13 assignments of two new macrocyclic lactones isolated from Streptomyces sp 211726 and revised assignments of Azalomycins F-3a, F-4a and F-5a, MAGNETICRESONANCEINCHEMISTRY, 2011, 第 6 作者
（401） Extraction and PTP1B inhibitory activity of bromophenols from the marine red alga Symphyocladia latiuscula, CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2011, 第 6 作者
（402） Extraction and PTP1B inhibitory activity of bromophenols from the marine red alga Symphyocladia latiuscula, Extraction and PTP1B inhibitory activity of bromophenols from the marine red alga Symphyocladia latiuscula, 中国海洋湖沼学报：英文版, 2011, 第 6 作者
（403） Benzamides and Quinazolines from a Mangrove Actinomycetes Streptomyces sp (No. 061316) and Their Inhibiting Caspase-3 Catalytic Activity in Vitro, CHEMICAL & PHARMACEUTICAL BULLETIN, 2011, 第 11 作者
（404） Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways, DIABETES, 2011, 第 10 作者
（405） Discovery and structural modification of novel inhibitors of PTP1B inspired by the ACT fragment of scleritodermin A, MEDCHEMCOMM, 2011, 第 9 作者  通讯作者
（406） Microwave-assisted construction of triazole-linked amino acid-glucoside conjugates as novel PTP1B inhibitors, NEW JOURNAL OF CHEMISTRY, 2011, 第 12 作者  通讯作者
（407） Discovery and Structure-activity Relationships of Tetrahydro-3H-cyclopentacquinolines Scaffold-based Potential PTP1B Inhibitors, CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2011, 第 7 作者
（408） Facile fabrication of promising protein tyrosine phosphatase (PTP) inhibitor entities based on ���clicked��� serine/threonine���monosaccharide hybrids, BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 第 10 作者
（409） Cytotoxic Amide Alkaloids from Piper boehmeriaefolium, JOURNAL OF NATURAL PRODUCTS, 2011, 第 13 作者
（410） Monosaccharide as a Central Scaffold Toward the Construction of Salicylate-Based Bidentate PTP1B Inhibitors via Click Chemistry, BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2011, 第 9 作者
（411） Diterpenes from the Hainan Soft Coral Lobophytum cristatum Tixier-Durivault, JOURNAL OF NATURAL PRODUCTS, 2011, 第 7 作者
（412） Synthesis of novel 6-triazologlycolipids via click chemistry and their preliminary cytotoxicity assessments, MOLECULAR DIVERSITY, 2011, 第 7 作者
（413） Synthesis of Triazole-Linked Amino Acid-Aryl C-Glycoside Hybrids via Click Chemistry as Novel PTP1B Inhibitors, CHINESE JOURNAL OF CHEMISTRY, 2011, 第 6 作者  通讯作者
（414） PKA phosphorylation couples hepatic inositol-requiring enzyme 1 alpha to glucagon signaling in glucose metabolism, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 第 12 作者
（415） A new staurosporine analog from Actinomycetes Streptomyces sp (172614), JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2011, 第 5 作者
（416） Synthesis and Biological Evaluation of Novel Indolin-2-One Derivatives as Protein Tyrosine Phosphatase 1B Inhibitors, LETTERS IN ORGANIC CHEMISTRY, 2011, 第 6 作者
（417） Structural insights into the homology and differences between mouse protein tyrosine phosphatase-sigma and human protein tyrosine phosphatase-sigma, Acta Biochimica et Biophysica Sinica, 2011, 第 6 作者
（418） Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 第 5 作者  通讯作者
（419） Microwave-Accelerated Click Chemistry: Expeditious Synthesis of Novel Triazole-linked Salicylic beta-D-O-Glycosides with PTP1B Inhibitory Activity, BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2010, 第 9 作者  通讯作者
（420） 8,8-Dimethyldihydroberberine with improved bioavailability and oral efficacy on obese and diabetic mouse models, BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 第 11 作者
（421） Azalomycin F 4a 2-ethylpentyl ester, a new macrocyclic lactone, from mangrove actinomycete Streptomyces sp. 211726, CHINESE CHEMICAL LETTERS, 2010, 第 4 作者
（422） Expeditious preparation of triazole-linked glycolipids via microwave accelerated click chemistry and their electrochemical and biological assessments, TETRAHEDRON, 2010, 第 7 作者
（423） Synthesis and antitumor evaluation of methyl spongoate analogs, STEROIDS, 2010, 第 4 作者
（424） Discovery of novel PTP1B inhibitors with antihyperglycemic activity, ACTA PHARMACOLOGICA SINICA, 2010, 第 10 作者
（425） AMPK Activators as Novel Therapeutics for Type 2 Diabetes, CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2010, 第 4 作者
（426） Discovery of novel PTP1B inhibitors with antihyperglycemic activity, Discovery of novel PTP1B inhibitors with antihyperglycemic activity, 中国药理学报：英文版, 2010, 第 10 作者
（427） Dammaranes from Gynostemma pentaphyllum and synthesis of their derivatives as inhibitors of protein tyrosine phosphatase 1B, BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 第 3 作者  通讯作者
（428） 海洋放线菌Streptomyces sp.（No.30701）次生代谢产物研究, Secondary metabolites from marine actinomycete Streptomyces sp.(No.30701), 中国药物化学杂志, 2010, 第 6 作者
（429） Phenolic compounds from the leaves of Cyclocarya paliurus (Batal.) Ijinskaja and their inhibitory activity against PTP1B, FOOD CHEMISTRY, 2010, 第 7 作者  通讯作者
（430） Characterization and Online Detection of Surfactin Isomers Based on HPLC-MSn Analyses and Their Inhibitory Effects on the Overproduction of Nitric Oxide and the Release of TNF-alpha and IL-6 in LPS-Induced Macrophages, MARINE DRUGS, 2010, 第 7 作者
（431） Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kappa B activation, BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 第 5 作者
（432） Design and synthesis of a highly selective fluorescent turn-on probe for thiol bioimaging in living cells, ORGANIC & BIOMOLECULAR CHEMISTRY, 2010, 第 5 作者
（433） High-Throughput Assay for Modulators of Mitochondrial Membrane Potential Identifies a Novel Compound With Beneficial Effects on db/db Mice, DIABETES, 2010, 第 11 作者  通讯作者
（434） LGH00031, a novel ortho-quinonoid inhibitor of cell division cycle 25B, inhibits human cancer cells via ROS generation, ACTA PHARMACOLOGICA SINICA, 2009, 第 9 作者  通讯作者
（435） LGH00031, a novel ortho-quinonoid inhibitor of cell division cycle 25B, inhibits human cancer cells via ROS generation, LGH00031, a novel ortho-quinonoid inhibitor of cell division cycle 25B, inhibits human cancer cells via ROS generation, 中国药理学报：英文版, 2009, 
（436） Synthesis of tanshinone IIA analogues and their inhibitory activities against Cdc25 phosphatases, CHINESE CHEMICAL LETTERS, 2009, 第 4 作者
（437） AMP-activated Protein Kinase Is Involved in Neural Stem Cell Growth Suppression and Cell Cycle Arrest by 5-Aminoimidazole-4-carboxamide-1-��-d-ribofuranoside and Glucose Deprivation by Down-regulating Phospho-retinoblastoma Protein and Cyclin D, JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 第 5 作者
（438） Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 第 7 作者  通讯作者
（439） High-throughput screening using pseudotyped lentiviral particles: A strategy for the identification of HIV-1 inhibitors in a cell-based assay, ANTIVIRAL RESEARCH, 2009, 第 10 作者
（440） Actinomycetes for Marine Drug Discovery Isolated from Mangrove Soils and Plants in China, MARINE DRUGS, 2009, 第 8 作者
（441） Synthesis and Biological Evaluation of C7-Demethyl Largazole Analogues, CHEMMEDCHEM, 2009, 第 3 作者
（442） Design and Synthesis of Matrix Metalloprotease Photoaffinity Trimodular Probes, CHINESE JOURNAL OF CHEMISTRY, 2009, 第 6 作者  通讯作者
（443） Actinomycetes for Marine Drug Discovery Isolated from Mangrove Soils and Plants in China. (vol 7, pg 24, 2009), MARINE DRUGS, 2009, 第 8 作者
（444） Diterpenoids from the Hainan Soft Coral Sinularia parva, HELVETICA CHIMICA ACTA, 2009, 第 4 作者
（445） Two New Unprecedented Acetonyl-Bearing Sesquiterpenes from the Hainan Sponge Dysidea fragilis, CHEMISTRY & BIODIVERSITY, 2009, 第 2 作者
（446） Discovery and characterization of a novel inhibitor of CDC25B, LGH00045, Discovery and characterization of a novel inhibitor of CDC25B, LGH00045, 中国药理学报：英文版, 2008, 第 10 作者
（447） Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species, JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 第 11 作者
（448） AICAR Induces Astroglial Differentiation of Neural Stem Cells via Activating the JAK/STAT3 Pathway Independently of AMP-activated Protein Kinase, JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 第 9 作者  通讯作者
（449） Discovery and characterization of a novel inhibitor of CDC25B, LGH00045, ACTA PHARMACOLOGICA SINICA, 2008, 第 10 作者  通讯作者
（450） Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: A mechanism for the action of berberine to activate AMP-Activated protein kinase and improve insulin action, DIABETES, 2008, 第 12 作者
（451） Sesquiterpenes from the Hainan sponge Dysidea septosa, JOURNAL OF NATURAL PRODUCTS, 2008, 第 2 作者
（452） Discovery of a novel competitive inhibitor of PTP1B by high-throughput screening, ACTA PHARMACOLOGICA SINICA, 2008, 第 7 作者  通讯作者
（453） Bispuupehenone from the South Chinese Sea sponge Dysidea sp., ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 第 3 作者
（454） Oleanolic acid and its derivatives: New inhibitor of protein tyrosine phosphatase 1B with cellular activities, BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 第 7 作者  通讯作者
（455） Small Molecule Antagonizes Autoinhibition and Activates AMP-activated Protein Kinase in Cells, JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 第 11 作者
（456） Synthesis of (S)-, (R)-, and (rac)-2-amino-3,3-bis(4-fluorophenyl)propanoic acids and an evaluation of the DPP IV inhibitory activity of Denagliptin diastereomers, TETRAHEDRON, 2008, 第 7 作者
（457） Discovery of a novel competitive inhibitor of PTP1B by high-throughput screening, Discovery of a novel competitive inhibitor of PTP1B by high-throughput screening, 中国药理学报：英文版, 2008, 
（458） Conserved ��-Helix Acts as Autoinhibitory Sequence in AMP-activated Protein Kinase �� Subunits, JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 第 7 作者
（459） Conserved alpha-helix acts as autoinhibitory sequence in AMP-activated protein kinase alpha subunits, JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 第 7 作者  通讯作者
（460） Total synthesis of illudalic acid and its analogs as LAR inhibitors, DRUGS OF THE FUTURE, 2007, 第 2 作者
（461） Two New Coumarins from Fraxinus chinensis Rexb., Two New Coumarins from Fraxinus chinensis Rexb., 植物学报：英文版, 2007, 第 3 作者
（462） Activity-based protein profiling for type I methionine aminopeptidase by using photo-affinity trimodular probes, CHEMBIOCHEM, 2007, 第 4 作者  通讯作者
（463） Growth inhibition and induction of early apoptosis by arenicolsterol A, a novel cytotoxic enolic sulphated sterol from the marine annelid, Arenicola cristata, JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2007, 第 6 作者
（464） 糖尿病和肥胖症治疗新靶点ptp1b抑制剂的研究进展, 生命科学, 2006, 第 3 作者
（465） 炎症caspase与相关疾病, 生命科学, 2006, 第 4 作者
（466） Ursolic acid and its derivative inhibit protein tyrosine phosphatase 1B, enhancing insulin receptor phosphorylation and stimulating glucose uptake, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2006, 第 8 作者
（467） 高通量筛选JAK-STAT6信号传导通路抑制剂方法的初步建立, Identification of inhibitors that target JAK-STAT6 signal pathway via high-throughput screening, 中国药理学通报, 2006, 第 4 作者
（468） “Click”化学在药物发现中的应用, Click chemistry in drug discovery, 生命科学, 2006, 第 3 作者
（469） Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2006, 第 8 作者  通讯作者
（470） Construction of a small peptide library related to inhibitor OM99-2 and its structure-activity relationship to beta-secretase, ACTA PHARMACOLOGICA SINICA, 2006, 第 8 作者
（471） Design and synthesis of a biotin-tagged photoaffinity probe of paeoniflorin, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 第 7 作者  通讯作者
（472） Construction of a small peptide library related to inhibitor OM99-2 and its structure-activity relationship to b-secretase, ACTA PHARMACOLOGICA SINICA, 2006, 第 8 作者
（473） 光亲和标记技术在药物发现中的应用, Photoaffinity labeling in drug discovery, 生命科学, 2005, 第 3 作者
（474） 多功能的蛋白：糖原合成酶激酶-3, Multi-function kinase: glycogen synthase kinase-3, 生命科学, 2005, 第 2 作者

   

（ 1 ） 先天性高胰岛素血症靶标发现和创新药物的研发, 负责人, 研究所自主部署, 2023-10--2026-09
（ 2 ） 多糖-05-S2抗肺纤维化候选药物研究, 负责人, 地方任务, 2023-01--2024-12
（ 3 ） 肝癌演进过程中肿瘤及免疫微环境异常糖基化的动态可视化、新功能靶标发现与特异性化学干预, 负责人, 国家任务, 2023-01--2025-12
（ 4 ） BTK靶向调控创新药物发现与系统临床前研究, 负责人, 研究所自主部署, 2022-06--2025-06
（ 5 ） NLRP3抑制剂治疗非酒精性脂肪性肝炎探索性研究, 负责人, 研究所自主部署, 2022-06--2024-06
（ 6 ） 糖靶向RNAi递药系统的模式动物评价, 负责人, 国家任务, 2022-01--2026-12
（ 7 ） DDR选择性抑制剂治疗肺纤维化探索性研究, 负责人, 研究所自主部署, 2021-05--2023-04
（ 8 ） CHK1抑制剂生物标志物研究, 负责人, 研究所自主部署, 2021-05--2023-04
（ 9 ） 糖苷类抗糖尿病候选新药发现研究, 负责人, 地方任务, 2021-01--2022-12
（ 10 ） 基于肠道内分泌功能调节的糖类药物研发关键技术, 负责人, 地方任务, 2021-01--2022-07
（ 11 ） 羟氯喹临床研究和药物筛选, 负责人, 国家任务, 2020-02--2020-06
（ 12 ） 抗新型冠状病毒筛选体系建立, 负责人, 地方任务, 2020-02--2021-01
（ 13 ） 二甲双胍通过调控前额叶AMPK活性缓解社交压力导致焦虑障碍的作用及机制研究, 负责人, 国家任务, 2020-01--2023-12
（ 14 ） 基于表型筛选、人工智能、特色天然产物及高效合成的一体化抗药物耐药研究, 负责人, 地方任务, 2019-11--2022-10
（ 15 ） 新型选择性BTK抑制剂SS-001抗淋巴瘤的系统临床前研究, 负责人, 地方任务, 2019-04--2022-03
（ 16 ） 非酒精性脂肪性肝炎及器官纤维化疾病创新药物的临床前研究与开发, 负责人, 国家任务, 2019-01--2020-12
（ 17 ） 共价结合药物研发技术体系, 负责人, 国家任务, 2018-01--2020-12
（ 18 ） 蛋白酪氨酸磷酸酶SHP1选择性别构激活剂的发现及抗血液肿瘤活性研究, 负责人, 国家任务, 2018-01--2021-12
（ 19 ） 王宽诚率先人才计划卢嘉锡国际团队细胞代谢紊乱疾病的药物新靶标和新分子实体研究, 负责人, 中国科学院计划, 2018-01--2020-12
（ 20 ） 靶向DRAK2的抗糖尿病候选药物研究, 负责人, 地方任务, 2016-07--2019-06
（ 21 ） BTK抑制剂候选新药抗血液肿瘤的个性化研究, 负责人, 中国科学院计划, 2016-07--2019-06
（ 22 ） 靶向DPP-4的超长效降糖候选药物研究, 负责人, 研究所自主部署, 2015-09--2016-08
（ 23 ） 靶向DPP4的抗糖尿病候选新药DC407的临床前研究, 负责人, 地方任务, 2014-07--2017-09
（ 24 ） 脂肪肝和高脂血症的早期干预及原理验证研究, 负责人, 国家任务, 2012-01--2016-12
（ 25 ） 代谢性疾病药物药理学, 负责人, 国家任务, 2012-01--2015-12
（ 26 ） 诱导干细胞定向分化小分子药物的研究, 负责人, 中国科学院计划, 2011-01--2015-12