基本信息
郑永唐  男  博导  中国科学院昆明动物研究所
电子邮件: zhengyt@mail.kiz.ac.cn
通信地址: 云南省昆明市教场东路32号
邮政编码: 650223

招生信息

   
招生专业
071009-细胞生物学
071010-生物化学与分子生物学
招生方向
病毒免疫学与艾滋病动物模型
病毒免疫学

教育背景

1993-08--1997-08 中国科学院昆明动物研究所 理学博士
1986-08--1989-02 中国科学院昆明动物研究所 理学硕士
1978-10--1983-12 江西医学院 医学学士
学历
中国科学院 -- 研究生
学位
中国科学院 -- 博士

工作经历

   
工作简历
1989-02--今 中国科学院昆明动物研究所 助理研究员、副研究员、研究员
1983-12--1986-07 赣南医学院 助教
社会兼职
2008-04--今 省(自治区、直辖市)科协委员

专利与奖励

   
奖励信息
(1) 云南省HIV毒种库建设及分子流,三等奖,省级,2009
(2) 两栖动物活性多肽的结构与功能研,一等奖,省级,2008
(3) 抗HIV药物研发关键技术建立及,一等奖,省级,2008
(4) 云南省艾滋病综合防治研究,三等奖,部委级,2007
(5) 核糖体失活蛋白抗艾滋病病毒活性,二等奖,省级,2004
(6) 猴艾滋病的诊断和国产猴群感染状,三等奖,省级,1995
专利成果
[1] 刘阳, 郑盼, 苏立山, 郑永唐, 张立国. 使用可溶性CD24用于治疗获得性免疫缺陷综合征(HIV/AIDS)的方法. US: CN112543643A, 2021-03-23.

[2] 乔凯旋, 郑永唐, 刘鑫, 刘丰亮, 范雪刚. 一种基于CRISPR-Cas9系统构建EPB41基因敲除THP-1细胞系的方法. CN: CN112481305A, 2021-03-12.

[3] 刘海洋, 郑永唐, 刘晖, 姚债文, 秦徐杰, 罗荣华, 倪伟, 杨柳萌. 一种具有抗病毒活性的大叶桉酮及其制备方法和用途. CN: CN112159318A, 2021-01-01.

[4] 况轶群, 郑永唐, 汤贝贝, 洪琛, 庞伟, 田仁荣. 一种北平顶猴T细胞的体外扩增方法. CN: CN111607565A, 2020-09-01.

[5] 代绍兴, 黄京飞, 陈欢, 郑永唐, 李功华, 李文兴. 西曲瑞克在制备治疗艾滋病的药物中的应用. CN: CN107007814B, 2020-03-17.

[6] 李明华, 韩建保, 都洪弟, 瞿望, 冯小丽, 邓忠华, 郑永唐. 一种可移动式室内风口密闭封堵检测装置. CN: CN210004019U, 2020-01-31.

[7] 李明华, 韩建保, 瞿望, 都洪弟, 冯小丽, 邓忠华, 郑永唐. 一种活毒废水处理间被动送风压力控制装置. CN: CN209960701U, 2020-01-17.

[8] 何严萍, 张洪彬, 郑永唐, 武玉萌, 唐成润, 芮若梅, 王江远, 杨柳萌. 一种2-硫甲基吡唑嘧啶酮类化合物、其制备方法、药物组合物及应用. CN: CN110483487A, 2019-11-22.

[9] 何严萍, 张洪彬, 郑永唐, 张玉芳, 唐成润, 丁伟, 杨柳萌, 李一明. 一种DACOs类NNRTIs氨基酸酯衍生物、其制备方法、药物组合物及应用. CN: CN110483417A, 2019-11-22.

[10] 何严萍, 郑永唐, 张玉芳, 向思颖, 张洪彬, 赵智东, 杨柳萌. 6-环已甲基嘧啶酮类HIV逆转录酶抑制剂、其制备方法和用途. CN: CN106866548B, 2019-08-27.

[11] 代绍兴, 黄京飞, 陈欢, 郑永唐, 李功华, 李文兴. 达巴万星在制备治疗艾滋病的药物中的应用. CN: CN106668833B, 2019-05-14.

[12] 代绍兴, 黄京飞, 陈欢, 郑永唐, 李功华, 李文兴. 蒽环类化合物在制备治疗艾滋病的药物中的应用. 中国: CN107041891A, 2017-08-15.

[13] 何严萍, 郑永唐, 赵智东, 向思颖, 张洪彬, 张玉芳, 杨柳萌. 一种S‑DACOs类NNRTIs及其制备方法和用途. 中国: CN106866549A, 2017-06-20.

[14] 杨小生, 郑永唐, 郝小江, 汪冶. 4,5-二取代-2-吡咯烷酮化合物的新用途. 中国: CN103877080A, 2014-06-25.

[15] 胡英杰, 邱声祥, 符林春, 郑永唐. 一种治疗艾滋病的药物组合物及其制备方法、质量控制方法和用途. 中国: CN102727850A, 2012-10-17.

[16] 刘吉开, 郑永唐, 赵金华, 吴明一, 黄宁, 李姿, 高娜, 文丹丹, 连武, 何江波. 低分子量岩藻糖化糖胺聚糖的羧基还原衍生物及其制备方法与用途. 中国: CN102558389A, 2012-07-11.

[17] 周俊, 郑永唐, 黄圣卓, 赵友兴, 张兴杰, 胡江苗, 王睿睿, 刘玉清, 张旋. 瑞香烷型二萜原酸酯类化合物,其药物组合物及其制备方法和应用. 中国: CN102344455A, 2012-02-08.

[18] 黄成钢, 李志雄, 范明松, 郑永唐, 唐意红, 吴斌, 孙兆林, 陈明苍, 陈璐莹, 罗荣华, 王睿睿. 异黄酮类化合物的用途. 中国: CN102302484A, 2012-01-04.

[19] 邵鹏柱, 郑永唐, 黄锦波, 罗嘉懿, 王睿睿, 麦雅丝. 修饰的玉米核糖体失活蛋白前体及其应用和蛋白纯化方法. 中国: CN102234638A, 2011.11.09.

[20] 陈芬儿, 马晓东, 古双喜, 何秋琴, 郑永唐, 张旋, 杨柳萌. N-苯基芳基甲酰胺衍生物及其制备方法和用途. 中国: CN102219717A, 2011.10.19.

[21] 陈芬儿, 马晓东, 古双喜, 何秋琴, 郑永唐, 张旋, 杨柳萌. 1-萘基苯甲酮衍生物及其制备方法和用途. 中国: CN102206177A, 2011.10.05.

[22] 赵金华, 刘吉开, 郑永唐, 吴明一, 黄宁, 李姿, 何江波. 低分子量糖基化硫酸软骨素及其在抗HIV-1药物制备中的用途. 中国: CN102247401A, 2011-11-23.

[23] 陈芬儿, 古双喜, 马晓东, 何秋琴, 郑永唐, 张旋, 杨柳萌. 一种萘苯醚类苯磺酰胺衍生物及其制备方法和用途. 中国: CN102229547A, 2011-11-02.

[24] 陈芬儿, 马晓东, 古双喜, 何秋琴, 郑永唐, 张旋, 杨柳萌. 二苯甲醇衍生物及其制备方法和用途. 中国: CN102212022A, 2011-10-12.

[25] 陈芬儿, 何秋琴, 吴海秋, 古双喜, 马晓东, 郑永唐, 张旋, 杨柳萌. 一种5-羟基喹诺酮类衍生物及其制备方法和用途. 中国: CN102212032A, 2011-10-12.

[26] 郝小江, 郑永唐, 何红平, 黄宁, 谭承建, 李春燕, 邸迎彤, 王睿睿. 三宝木内酯A-D,其药物组合物,制备方法和应用. 中国: CN102101864A, 2011-06-22.

[27] 刘靖平, 孙汉董, 张洪彬, 郑永唐, 肖伟烈, 普建新, 王睿睿, 杨柳萌. 含氮类联苯化合物,含其的药物组合物,其制备方法及其在抗HIV-1中的应用. 中国: CN102010398A, 2011-04-13.

[28] 何严萍, 郑永唐, 李聪, 张虽栓, 龙晶, 欧灵澄. 6-环己甲基取代S-DABO类化合物、其合成方法和用途. 中国: CN101177413B, 2010-11-17.

[29] 黄成钢, 郑永唐, 李志雄, 王睿睿, 马春辉, 田仁荣, 唐意红, 范明松, 孙兆林, 叶 冠, 吴 斌. 毛蕊异黄酮-7-氧-β-D-吡喃葡萄糖苷或其盐在抗艾滋病中的应用. 中国: CN101590072, 2009-12-02.

[30] 何严萍, 郑永唐, 李 聪, 龙 晶, 饶之坤, 张虽栓, 欧灵澄. S-DABO类化合物、其合成方法和用途. 中国: CN100519540, 2009-07-29.

[31] 陈纪军, 顾 琼, 郑永唐, 王睿睿, 张雪梅, 周 俊. 盐肤木内酯A,其制备方法和其在制药中的应用. 中国: CN100434426, 2008-11-19.

[32] 李蓉涛, 孙汉董, 郑永唐, 杨柳萌, 王睿睿, 林中文, 赵勤实. 治疗艾滋病的药物及其应用. 中国: CN100430053, 2008-11-05.

[33] 蒋华良, 沈 旭, 郑永唐, 李 剑, 柳 红, 杜 丽, 杨柳萌, 王睿睿, 王乙平, 陈凯先. 2,4-二取代氨基-6-取代-1,3,5三嗪或1,3-嘧啶类化合物、其制备方法、药物组合物及用途. 中国: CN101245051, 2008-08-20.

[34] 戴好富, 郑永唐, 梅文莉, 白 雪, 曾艳波, 张 兴. 长春花及其提取物在制备抗艾滋病药物中的用途. 中国: CN101167771, 2008-04-30.

[35] 靳 艳, 郑永唐, 王建华, 张 卫. 一种多皱软磺酸在抗HIV-1病毒的药物中的应用. 中国: CN100358516, 2008-01-02.

[36] 陈世武, 田瑄, 郑永唐, 王云华, 涂永强. 鬼臼类化合物及其用途. 中国: CN1911953, 2007.02.14.

[37] 李蓉涛, 孙汉董, 郑永唐, 王睿睿, 杨柳萌, 林中文, 赵勤实. 抗艾滋病化合物,其制备方法和以该类化合物为活性成分的药物组合物及其应用. 中国: CN100338067, 2007-09-19.

[38] 肖伟烈, 郑永唐, 孙汉董, 杨柳萌, 田仁荣, 普建新, 李蓉涛. 治疗艾滋病的药物组合物,其制备方法及其用途. 中国: CN1931151, 2007-03-21.

[39] 刘吉开, 郑永唐, 秦向东, 杨柳萌, 董泽军, 王睿睿, 谭建文. 炭球菌素及其制备方法和应用. 中国: CN1238357, 2006-01-25.

[40] 刘吉开, 郑永唐, 丁智慧, 王茜, 瞿燕, 董泽军. 一种预防或治疗艾滋病的药物及其制备方法和应用. 中国: CN1197560, 2005.04.20.

[41] 陈纪军, 郑永唐, 王茜, 张雪梅, 顾琼, 江志勇. 5,6-二羟基-2-(4-羟苯基)-4-酮-4H-1-苯并吡喃基-7-羟基-β-D-葡萄糖醛酸在制药中的应用. 中国: CN1193765, 2005.03.23.

[42] 郑永唐, 刘广杰, 杨柳萌. 一种抗人免疫缺陷病毒Ⅰ型p24蛋白的单克隆抗体及其应用. 中国: CN1687133, 2005-10-26.

[43] 普绍平, 郑永唐, 王玉天, 王茜, 刘伟平, 刘祝东, 高文桂, 余尧. 黄岑甙锌配合物药物用途. 中国: CN1189178, 2005-02-16.

[44] 张云, 郑永唐, 张玉洁, 王建华, 李文辉, 王茜. 蛇毒L-氨基酸氧化酶在制备艾滋病治疗药物中的应用. 中国: CN1526445, 2004-09-08.

[45] 陈纪军, 王易芬, 郑永唐, 罗士德, 曹建新, 唐绍宗, 王惠英, 刘广杰, 来国防. β-硝基苯乙烯在制备抗艾滋病药物中的应用. 中国: CN1136844, 2004-02-04.

[46] 张云, 赖仞, 郑永唐, 李文辉, 刘衡, 刘广杰. 大蹼铃蟾抗肿瘤蛋白及其制备方法和其基因. 中国: CN1374323, 2002-10-16.

[47] 张云, 赖仞, 郑永唐, 李文辉. 大蹼铃蟾抗精子多肽及其制备方法和在制药中的应用. 中国: CN1345883, 2002-04-24.

[48] 张云, 赖仞, 郑永唐, 刘广杰, 李文辉, 唐绍宗. 大蹼铃蟾多肽及其制备方法和在制药中的应用. 中国: CN1336386, 2002-02-20.

[49] 张云, 赖仞, 郑永唐, 唐绍宗, 李文辉. 大蹼铃蟾皮肤肽及其制备方法和在制药中的应用. 中国: CN1336384, 2002-02-20.

[50] 张云, 赖仞, 郑永唐, 唐绍宗, 李文辉. 大蹼铃蟾蛋白酶抑制剂及其制备方法和在制药中的应用. 中国: CN1336385, 2002-02-20.

[51] 陈纪军, 王易芬, 郑永唐, 罗士德, 曹建新, 唐绍宗, 王惠英, 刘广杰, 来国防. 抗艾滋病药物及其应用. 中国: CN1297736, 2001.06.06.

[52] 陈纪军, 王易芬, 郑永唐, 罗士德, 曹建新, 唐绍宗, 王惠英, 刘广杰, 来国防. 一种治疗艾滋病的药物组合物及其用途. 中国: CN1304722, 2001-07-25.

[53] 郑永唐, 贲昆龙, 金善炜, 周俊, 向邦平, 曹伯巽, 汪猷. 栝楼蛋白,其制备方法和在制药中的应用. 中国: CN1209435, 1999.03.03.

出版信息

   
发表论文
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[3] Wang, XueHui, Song, TianZhang, Zheng, HongYi, Li, YiHui, Zheng, YongTang. Jejunal epithelial barrier disruption triggered by reactive oxygen species in early SIV infected rhesus macaques. FREE RADICAL BIOLOGY AND MEDICINE[J]. 2021, 177: 143-155, http://dx.doi.org/10.1016/j.freeradbiomed.2021.10.026.
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[5] Wang, Siyao, Zhou, Qingqing, Chen, Xiaoping, Luo, RongHua, Li, Yunxue, Liu, Xinliang, Yang, LiuMeng, Zheng, YongTang, Wang, Ping. Modification of N-terminal alpha-amine of proteins via biomimetic ortho-quinone-mediated oxidation. NATURE COMMUNICATIONS[J]. 2021, 12(1): http://dx.doi.org/10.1038/s41467-021-22654-7.
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[379] 张高红, 陈亚丽, 唐宏, 郑永唐. SCID-hu小鼠:HIV研究的小型动物模型. 动物学研究. 2004, 25(4): 356-362, http://lib.cqvip.com/Qikan/Article/Detail?id=10218340.
[380] 张高红, 郑永唐. 多糖化合物抗HIV活性及应用. 中国生物工程杂志. 2004, 24(1): 6-10, http://lib.cqvip.com/Qikan/Article/Detail?id=9108482.
[381] 王茜, 杨柳萌, 郑永唐. 天然产物中的HIV—1非核昔类逆转录酶抑制剂. 中草药[J]. 2003, 34(4): 381-382,U001,U002, http://lib.cqvip.com/Qikan/Article/Detail?id=7742548.
[382] 汪剑平, 郑永唐, 贲昆龙, 刘广杰, 陈海宝, 曹者瑜. 抗HIV p24多肽单克隆抗体和抗血清的制备及初步应用. 中国人兽共患病杂志. 2002, 18(3): 13-16, http://lib.cqvip.com/Qikan/Article/Detail?id=6229253.
[383] 王建华, 王媛媛, 欧阳东云, 郑永唐. HIV感染中的细胞凋亡. 动物学研究. 2002, 23(6): 514-520, http://lib.cqvip.com/Qikan/Article/Detail?id=7206067.
[384] 王茜, 郑永唐, 戎隆富, 刘广杰. 半乳糖神经酰胺脂质体对HIV—1感染性的影响. 免疫学杂志. 2002, 18(2): 128-131, http://lib.cqvip.com/Qikan/Article/Detail?id=6063619.
[385] 王茜, 郑永唐. 非核苷类逆转录酶抑制剂在HIV—1中的作用. 中国药学杂志[J]. 2002, 37(12): 881-884, http://lib.cqvip.com/Qikan/Article/Detail?id=7181671.
[386] 郑永唐. 抗HIV药物的体外筛选和研究方法. 中国新药杂志. 2002, 11(8): 596-600, http://lib.cqvip.com/Qikan/Article/Detail?id=7006937.
[387] 段海平, 郑永唐, 达天武, 芮浚, 郭琛琨, 唐兴礼, 贲昆龙. 脱抗原牛角胎骨移植家兔后的特异性免疫反应. 免疫学杂志. 2002, 18(3): 204-206, http://lib.cqvip.com/Qikan/Article/Detail?id=6229465.
[388] 郑永唐, 王茜, 戎隆富. 脂质体携载抗HIV-1药物. 免疫学杂志. 2001, 115-118, http://lib.cqvip.com/Qikan/Article/Detail?id=1000538175.
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科研活动

   
科研项目
(1) 树鼩基础生物学及重要生物学特性研究,主持,部委级,2011-01--2013-12
(2) 非人灵长类的人类疾病模型建立,主持,部委级,2011-01--2013-12
(3) 抗HIV药物药效评价及新机理研究关键技术平台研究,主持,省级,2010-01--2011-12
(4) 治疗艾滋病化学药I类新药DC032片的临床前研究,主持,省级,2009-07--2011-12
(5) 天然免疫分子TRIM5a在HIV-1感染和复制中的限制作用及机制研究,主持,国家级,2009-01--2012-12
(6) 猕猴MamuI A剪接异构体对T细胞增殖及NK细胞杀伤能力的影响机制研究,主持,国家级,2009-01--2011-12
(7) 抗HIV药物药效评价及新机理研究关键技术平台研究,主持,国家级,2009-01--2011-12

指导学生

已指导学生

王睿睿  博士研究生  071002-动物学  

王媛媛  博士研究生  071002-动物学  

欧阳东云  博士研究生  071002-动物学  

张高红  博士研究生  071002-动物学  

李玉叶  博士研究生  071002-动物学  

王云华  博士研究生  071002-动物学  

刘红亮  博士研究生  071002-动物学  

王建华  博士研究生  071002-动物学  

王路  硕士研究生  071010-生物化学与分子生物学  

李少逰  博士研究生  071002-动物学  

涂源泉  博士研究生  071002-动物学  

龙晶  硕士研究生  071010-生物化学与分子生物学  

况轶群  博士研究生  071002-动物学  

孙鹥  博士研究生  071002-动物学  

刘武青  硕士研究生  071010-生物化学与分子生物学  

白雪  硕士研究生  071010-生物化学与分子生物学  

汤霞  硕士研究生  071010-生物化学与分子生物学  

夏厚军  博士研究生  071002-动物学  

戴正喜  博士研究生  071009-细胞生物学  

曹光  硕士研究生  071010-生物化学与分子生物学  

马建平  硕士研究生  071010-生物化学与分子生物学  

刘丰亮  博士研究生  071009-细胞生物学  

刘亚娟  硕士研究生  071010-生物化学与分子生物学  

黄宁  博士研究生  071009-细胞生物学  

现指导学生

张旋  博士研究生  071009-细胞生物学  

朱林  博士研究生  071009-细胞生物学  

张兴杰  博士研究生  071009-细胞生物学  

雷爱华  硕士研究生  071010-生物化学与分子生物学  

母丹  硕士研究生  071010-生物化学与分子生物学  

陈欢  硕士研究生  430139-生物工程  

姚志红  博士研究生  071009-细胞生物学  

周衍衡  博士研究生  071009-细胞生物学  

陈鑫  硕士研究生  071010-生物化学与分子生物学  

张明旭  硕士研究生  071010-生物化学与分子生物学  

陆翠林  硕士研究生  085238-生物工程  

朱家武  博士研究生  071009-细胞生物学  

张喜鹤  博士研究生  071009-细胞生物学  

罗梦婷  硕士研究生  071010-生物化学与分子生物学