单分子生物物理
膜蛋白和细胞膜生物物理

   

德国魏尔茨堡大学 19950801--19981001 博士

德国魏尔茨堡大学 19950801--19981001  博士研究生
美国伊利诺伊大学 19981101--20010501  博士后

   

1967年出生，1989年华中理工大学（现华中科技大学）理学学士，1992年吉林大学理学硕士，1998年德国魏尔茨堡大学自然科学博士。1998年-2001年伊利诺伊大学芝加哥分校博士后。2000年获中科院“****”资助，2003年获国家“杰出青年”科学基金。2009年入选“新世纪百千万人才工程”国家级人选。现任中科院物理所研究员、所学术委员会委员、软物质物理重点实验室主任、SM4课题组组长。

新颖单分子研究技术的发展和应用；生物分子马达(解旋酶、核糖体等)的工作机理；膜蛋白的转运、插膜和跨膜机理。
每年招收研究生（硕博连读生或博士生）3名。欢迎各学科（物理、化学或生物）背景的青年学子报考。
http://sm4.iphy.ac.cn/

   

2003 国家杰出青年科学基金

[1] 黄星榞, 徐春华, 李明. 在小力下测算磁镊高度转换系数的方法及应用. CN: CN111721504B, 2022-02-18.

[2] 侯文清, 陆颖, 马东飞, 贺小龙, 李明. 观察活细胞细胞膜表面及附近生物大分子的荧光成像方法. CN: CN113008842A, 2021-06-22.

[3] 滕翠娟, 徐春华, 李明. 基于解旋酶检测DNA与蛋白质相互作用的方法. CN: CN110470844A, 2019-11-19.

[4] 翟永亮, 李明, 吴兰生. 横向磁镊装置. CN: CN104931419A, 2015-09-23.

[5] 李颖, 胡书新, 马丽, 刘仁威, 范苏娜, 李明. 荧光检测样品池及其制备方法. CN: CN105572046A, 2016-05-11.

[6] 翟永亮, 吴兰生, 李明, 胡书新, 李小龙. 一种多工位传动装置. CN: CN102874558A, 2013-01-16.

[7] 胡书新, 翟永亮, 吴兰生, 李明. 一种胶体晶体测试装置. CN: CN102914621A, 2013-02-06.

[8] 翟永亮, 吴兰生, 李明, 胡书新. 一种胶体晶体测试装置. CN: CN102914622A, 2013-02-06.

[9] 王爽, 翟永亮, 吴兰生, 李明. 成像磁镊装置及其与单分子荧光技术集成的系统和方法. CN: CN102749441A, 2012-10-24.

[10] 骆意勇, 吴兰生, 翟永亮, 李明. 实时观察胶体晶体内部缺陷的装置及方法. CN: CN101308101B, 2010-07-14.

[11] 李明, 孙博, 吴兰生, 翟永亮. 单分子操纵横向磁镊装置. CN: CN1869650A, 2006-11-29.

[12] 李明, 孙博, 吴兰生, 翟永亮. 单分子操纵横向磁镊装置. CN: CN1869650A, 2006-11-29.

   

[1] ADVANCED SCIENCE. 2024, 第 13 作者
[2] Nature Communications. 2024, 第 9 作者
[3] PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2024, 第 10 作者
[4] ADVANCED SCIENCE. 2024, 第 18 作者  通讯作者  
[5] SCIENCE ADVANCES. 2024, 第 11 作者  通讯作者  
[6] Yang, Chenguang, He, Xiaolong, Wang, Hao, Lin, Zhao, Hou, Wenqing, Lu, Ying, Hu, Shuxin, Li, Ming. Single-Molecule Monitoring of Membrane Association of the Necroptosis Executioner MLKL with Discernible Anchoring and Insertion Dynamics. NANO LETTERS[J]. 2023, 第 8 作者23(11): 4770-4777, http://dx.doi.org/10.1021/acs.nanolett.2c05062.
[7] Wang, YiZhou, Liu, Cuifang, Zhao, Jicheng, Yu, Juan, Luo, Anfeng, Xiao, Xue, Dou, ShuoXing, Ma, Lu, Wang, PengYe, Li, Ming, Li, Guohong, Yan, Jianbin, Chen, Ping, Li, Wei. H2A mono-ubiquitination differentiates FACT's functions in nucleosome assembly and disassembly. NUCLEIC ACIDS RESEARCH[J]. 2022, 第 10 作者50(2): 833-846, http://dx.doi.org/10.1093/nar/gkab1271.
[8] Fan, Qihui, Zheng, Yu, Wang, Xiaochen, Xie, Ruipei, Ding, Yu, Wang, Boyi, Yu, Xiaoyu, Lu, Ying, Liu, Liyu, Li, Yunliang, Li, Ming, Zhao, Yuanjin, Jiao, Yang, Ye, Fangfu. Dynamically Re-Organized Collagen Fiber Bundles Transmit Mechanical Signals and Induce Strongly Correlated Cell Migration and Self-Organization. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 第 11 作者60(21): 11858-11867, http://dx.doi.org/10.1002/anie.202016084.
[9] Hou, Wenqing, Ma, Dongfei, He, Xiaolong, Han, Weijing, Ma, Jianbing, Wang, Hao, Xu, Chunhua, Xie, Ruipei, Fan, Qihui, Ye, Fangfu, Hu, Shuxin, Li, Ming, Lu, Ying. Subnanometer-Precision Measurements of Transmembrane Motions of Biomolecules in Plasma Membranes Using Quenchers in Extracellular Environment. NANO LETTERS[J]. 2021, 第 12 作者  通讯作者  21(1): 485-491, http://dx.doi.org/10.1021/acs.nanolett.0c03941.
[10] 贾棋, 樊秦凯, 侯文清, 杨晨光, 王利邦, 王浩, 徐春华, 李明, 陆颖. DNA双链退火压力对DNA聚合酶gp5链置换的调控. 物理学报[J]. 2021, 第 8 作者70(15): 326-333, https://wulixb.iphy.ac.cn/cn/article/doi/10.7498/aps.70.20210707.
[11] Lu, Ke, Liu, Cuifang, Liu, Yinuo, Luo, Anfeng, Chen, Jun, Lei, Zhichao, Kong, Jingwei, Xiao, Xue, Zhang, Shuming, Wang, YiZhou, Ma, Lu, Dou, ShuoXing, Wang, PengYe, Li, Ming, Li, Guohong, Li, Wei, Chen, Ping. Curaxin-Induced DNA Topology Alterations Trigger the Distinct Binding Response of CTCF and FACT at the Single-Molecule Level. BIOCHEMISTRY[J]. 2021, 第 14 作者60(7): 494-499, http://dx.doi.org/10.1021/acs.biochem.1c00014.
[12] Huang, Xingyuan, Lu, Ying, Wang, Shuang, Sui, Mingyu, Li, Jinghua, Ma, Jianbing, Ma, Dongfei, Jia, Qi, Hu, Shuxin, Xu, Chunhua, Li, Ming. Mismatch sensing by nucleofilament deciphers mechanism of RecA-mediated homologous recombination. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 第 11 作者  通讯作者  117(34): 20549-20554, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456136/.
[13] 黄星榞, 隋明宇, 侯文清, 李明, 陆颖, 徐春华. RecA蛋白介导同源重组的步进式链交换. 物理学报[J]. 2020, 第 4 作者69(20): 344-351, https://wulixb.iphy.ac.cn/cn/article/doi/10.7498/aps.69.20200959.
[14] Huang XingYuan, Sui MingYu, Hou WenQing, Li Ming, Lu Ying, Xu ChunHua. Stepwise strand exchange during RecA-induced homologous recombination. ACTAPHYSICASINICA[J]. 2020, 第 4 作者69(20): https://www.webofscience.com/wos/woscc/full-record/WOS:000592460800036.
[15] Ma DongFei, Hou WenQing, Xu ChunHua, Zhao ChunYu, Ma JianBing, Huang XingYuan, Jia Qi, Ma Lu, Liu Cong, Li Ming, Lu Ying. Investigation of structure and dynamics of alpha-synuclein on membrane by quenchers-in-a-liposome fluorescence resonance energy transfer method. ACTA PHYSICA SINICA[J]. 2020, 第 10 作者69(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000527799000034.
[16] Qin, Zhenheng, Bin, Lulu, Hou, XiMiao, Zhang, Siqi, Zhang, Xia, Lu, Ying, Li, Ming, Modesti, Mauro, Xi, XuGuang, Sun, Bo. Human RPA activates BLM's bidirectional DNA unwinding from a nick. ELIFE[J]. 2020, 第 7 作者9: https://doaj.org/article/9ddd44bbe61043f6800b40aa02f180a5.
[17] 马东飞, 侯文清, 徐春华, 赵春雨, 马建兵, 黄星榞, 贾棋, 马璐, 刘聪, 李明, 陆颖. 脂质体包裹荧光受体方法研究α-突触核蛋白在磷脂膜上的结构和动态特征. 物理学报[J]. 2020, 第 10 作者69(3): 290-298, https://wulixb.iphy.ac.cn/cn/article/doi/10.7498/aps.69.20191607.
[18] Ma, JianBing, Chen, Ze, Xu, ChunHua, Huang, XingYuan, Jia, Qi, Zou, ZhenYu, Mi, ChenYang, Ma, DongFei, Lu, Ying, Zhang, HuiDong, Li, Ming. Dynamic structural insights into the molecular mechanism of DNA unwinding by the bacteriophage T7 helicase. NUCLEIC ACIDS RESEARCH[J]. 2020, 第 11 作者  通讯作者  48(6): 3156-3164, http://dx.doi.org/10.1093/nar/gkaa057.
[19] Diao, Wenwen, Tong, Xuezhi, Yang, Cheng, Zhang, Fengrong, Bao, Chun, Chen, Hao, Liu, Liyu, Li, Ming, Ye, Fangfu, Fan, Qihui, Wang, Jiangfei, OuYang, ZhongCan. Behaviors of Glioblastoma Cells in in Vitro Microenvironments. SCIENTIFIC REPORTS[J]. 2019, 第 8 作者9(1): https://doaj.org/article/cf5dacf241dc4635b020e5bcbd5b928d.
[20] DaguanNong, MingLi. An Improvement on the Combination of Magnetic Trap and Fluorescent Resonant Energy Transfer. Chinese Physics Letters[J]. 2019, 第 2 作者  通讯作者  36(3): 38701, https://cpl.iphy.ac.cn/10.1088/0256-307X/36/3/038701.
[21] Ma, Li, Hu, Shuxin, He, Xiaolong, Yang, Na, Chen, Licui, Yang, Chenguang, Ye, Fangfu, Wei, Taotao, Li, Ming. Detection of tBid Oligomerization and Membrane Permeabilization by Graphene-Based Single-Molecule Surface-Induced Fluorescence Attenuation. NANO LETTERS[J]. 2019, 第 9 作者  通讯作者  19(10): 6937-6944, 
[22] Ma, DongFei, Xu, ChunHua, Hou, WenQing, Zhao, ChunYu, Ma, JianBing, Huang, XingYuan, Jia, Qi, Ma, Lu, Diao, Jiajie, Liu, Cong, Li, Ming, Lu, Ying. Detecting Single-Molecule Dynamics on Lipid Membranes with Quenchers-in-a-Liposome FRET. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 第 11 作者  通讯作者  58(17): 5577-5581, http://dx.doi.org/10.1002/anie.201813888.
[23] Li, Meijing, Xia, Xian, Tian, Yuanyuan, Jia, Qi, Liu, Xiaoyu, Lu, Ying, Li, Ming, Li, Xueming, Chen, Zhucheng. Mechanism of DNA translocation underlying chromatin remodelling by Snf2. NATURE[J]. 2019, 第 7 作者  通讯作者  567(7748): 409-+, http://dx.doi.org/10.1038/s41586-019-1029-2.
[24] Zhang, Qian, Wen, Fengcai, Zhang, Siqi, Jin, Jiachuan, Bi, Lulu, Lu, Ying, Li, Ming, Xi, XuGuang, Huang, Xingxu, Shen, Bin, Sun, Bo. The post-PAM interaction of RNA-guided spCas9 with DNA dictates its target binding and dissociation. SCIENCE ADVANCES[J]. 2019, 第 7 作者5(11): 
[25] Ma Li, He XiaoLong, Li Ming, Hu ShuXin. Fluorescent investigation on process of tBid inducing membrane permeabilization. ACTA PHYSICA SINICA[J]. 2018, 第 3 作者67(14): https://www.webofscience.com/wos/woscc/full-record/WOS:000443207500029.
[26] Lu, XiMing, Li, Hui, You, Jing, Li, Wei, Wang, PengYe, Li, Ming, Dou, ShuoXing, Xi, XuGuang. Folding Dynamics of Parallel and Antiparallel G-Triplexes under the Influence of Proximal DNA. JOURNAL OF PHYSICAL CHEMISTRY B[J]. 2018, 第 6 作者122(41): 9499-9506, http://dx.doi.org/10.1021/acs.jpcb.8b08110.
[27] Huo, XinMei, Meng, Lifeng, Jiang, Tao, Li, Ming, Sun, FangZhen, Sun, Bo, Li, JianKe. Real-time observation of nucleoplasmin-mediated DNA decondensation and condensation reveals its specific functions as a chaperone. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS[J]. 2018, 第 4 作者1861(8): 743-751, http://dx.doi.org/10.1016/j.bbagrm.2018.07.002.
[28] Ma, JianBing, Jia, Qi, Xu, ChunHua, Li, JingHua, Huang, XingYuan, Ma, DongFei, Li, Ming, Xi, XuGuang, Lu, Ying. Asynchrony of Base-Pair Breaking and Nucleotide Releasing of Helicases in DNA Unwinding. JOURNAL OF PHYSICAL CHEMISTRY B[J]. 2018, 第 7 作者122(22): 5790-5796, 
[29] Xiao Xue, Dong Liping, Wang Yizhou, Wang Pengye, Li Ming, Li Guohong, Chen Ping, Li Wei. Dissection of structural dynamics of chromatin fibers by single-molecule magnetic tweezers. 生物物理学报：英文版[J]. 2018, 第 5 作者4(4): 222-232, http://lib.cqvip.com/Qikan/Article/Detail?id=676327040.
[30] Lu Yue, Ma JianBing, Teng CuiJuan, Lu Ying, Li Ming, Xu ChunHua. Binding process between E. coli SSB and ssDNA by single-molecule dynamics. ACTA PHYSICA SINICA[J]. 2018, 第 5 作者67(8): https://www.webofscience.com/wos/woscc/full-record/WOS:000443194600024.
[31] 马建兵, 翟永亮, 农大官, 李菁华, 付航, 张兴华, 李明, 陆颖, 徐春华. 基于片层光照明的新型单分子横向磁镊. 物理学报[J]. 2018, 第 7 作者67(14): 148702-1, http://lib.cqvip.com/Qikan/Article/Detail?id=675734491.
[32] 马丽, 贺小龙, 李明, 胡书新. tBid蛋白引发磷脂膜透化过程的研究. 物理学报[J]. 2018, 第 3 作者67(14): 148703-1, http://lib.cqvip.com/Qikan/Article/Detail?id=675734492.
[33] Chen, Ping, Dong, Liping, Hu, Mingli, Wang, YiZhou, Xiao, Xue, Zhao, Zhongliang, Yan, Jie, Wang, PengYe, Reinberg, Danny, Li, Ming, Li, Wei, Li, Guohong. Functions of FACT in Breaking the Nucleosome and Maintaining Its Integrity at the Single-Nucleosome Level. MOLECULAR CELL[J]. 2018, 第 10 作者  通讯作者  71(2): 284-+, http://dx.doi.org/10.1016/j.molcel.2018.06.020.
[34] Xue Xiao, Liping Dong, Yi-Zhou Wang, Peng-Ye Wang, Ming Li, Guohong Li, Ping Chen, Wei Li. Dissection of structural dynamics of chromatin fibers by single-molecule magnetic tweezers. 生物物理学报：英文版[J]. 2018, 第 5 作者4(4): 222-232, http://lib.cqvip.com/Qikan/Article/Detail?id=676327040.
[35] Teng CuiJuan, Lu Yue, Ma JianBing, Li Ming, Lu Ying, Xu ChunHua. Interaction between Sso7d and DNA studied by single-molecule technique. ACTA PHYSICA SINICA[J]. 2018, 第 4 作者67(14): https://www.webofscience.com/wos/woscc/full-record/WOS:000443207500026.
[36] 陆越, 马建兵, 黄星榞, 肖雪, 李明, 陆颖, 徐春华. 单分子磁镊测量高亲和反应系数. 高等学校化学学报[J]. 2018, 第 5 作者39(6): 1228-1234, http://lib.cqvip.com/Qikan/Article/Detail?id=675402643.
[37] Lu Yue, Ma Jianbing, Huang Xingyuan, Xiao Xue, Li Ming, Lu Ying, Xu Chunhua. Measuring the Reaction Rates of High Affinity Reactions by Single-molecule Magnetic Tweezers. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE[J]. 2018, 第 5 作者39(6): 1228-1234, https://www.webofscience.com/wos/woscc/full-record/WOS:000439940300018.
[38] Lu Yue, Ma JianBing, Teng CuiJuan, Lu Ying, Li Ming, Xu ChunHua. Binding process between E. coli SSB and ssDNA by single-molecule dynamics. ACTA PHYSICA SINICA[J]. 2018, 第 5 作者67(8): 
[39] Ma, Li, Li, Ying, Ma, Jianbing, Hu, Shuxin, Li, Ming. Watching Three-Dimensional Movements of Single Membrane Proteins in Lipid Bilayers. BIOCHEMISTRY[J]. 2018, 第 5 作者  通讯作者  57(31): 4735-4740, 
[40] Ma JianBing, Zhai YongLiang, Nong DaGuan, Li JingHua, Fu Hang, Zhang XingHua, Li Ming, Lu Ying, Xu ChunHua. Single molecule transverse magnetic tweezers based on light sheet illumination. ACTA PHYSICA SINICA[J]. 2018, 第 7 作者67(14): https://www.webofscience.com/wos/woscc/full-record/WOS:000443207500028.
[41] Liu, Renwei, Fan, Suna, Xiao, Dongdong, Zhang, Jin, Liao, Mengzhou, Yu, Shansheng, Meng, Fanling, Liu, Baoli, Gu, Lin, Meng, Sheng, Zhang, Guangyu, Zheng, Weitao, Hu, Shuxin, Li, Ming. Free-Standing Single-Molecule Thick Crystals Consisting of Linear Long-Chain Polymers. NANO LETTERS[J]. 2017, 第 14 作者  通讯作者  17(3): 1655-1659, 
[42] ZhenYeZhao, ChunHuaXu, JingShi, JingHuaLi, JianBingMa, QiJia, DongFeiMa, MingLi, YingLu. Bloom's syndrome protein unfolding G-quadruplexes in two pathways. Chinese Physics B[J]. 2017, 第 8 作者26(8): 88701-088701, https://cpb.iphy.ac.cn/EN/10.1088/1674-1056/26/8/088701.
[43] LiMa, YingLi, MingLi, ShuxinHu. Protein-membrane interactions investigated with surface-induced fluorescence attenuation. Chinese Physics B[J]. 2017, 第 3 作者26(12): 128708-128708, https://cpb.iphy.ac.cn/EN/10.1088/1674-1056/26/12/128708.
[44] Fan, Qihui, Liu, Ruchuan, Jiao, Yang, Tian, Chunxiu, Farrell, James D, Diao, Wenwen, Wang, Xiaochen, Zhang, Fengrong, Yuan, Wei, Han, Haibo, Chen, Jinfeng, Yang, Yue, Zhang, Xixiang, Ye, Fangfu, Li, Ming, Ouyang, Zhongcan, Liu, Liyu. A novel 3-D bio-microfluidic system mimicking in vivo heterogeneous tumour microstructures reveals complex tumour-stroma interactions. LAB ON A CHIP[J]. 2017, 第 15 作者17(16): 2852-2860, http://dx.doi.org/10.1039/c7lc00191f.
[45] Wu, WenQiang, Hou, XiMiao, Zhang, Bo, Fosse, Philippe, Rene, Brigitte, Mauffret, Olivier, Li, Ming, Dou, ShuoXing, Xi, XuGuang. Single-molecule studies reveal reciprocating of WRN helicase core along ssDNA during DNA unwinding. SCIENTIFIC REPORTS[J]. 2017, 第 7 作者7: http://dx.doi.org/10.1038/srep43954.
[46] Lin, Wenxia, Ma, Jianbing, Nong, Daguan, Xu, Chunhua, Zhang, Bo, Li, Jinghua, Jia, Qi, Dou, Shuoxing, Ye, Fangfu, Xi, Xuguang, Lu, Ying, Li, Ming. Helicase Stepping Investigated with One-Nucleotide Resolution Fluorescence Resonance Energy Transfer. PHYSICAL REVIEW LETTERS[J]. 2017, 第 12 作者119(13): https://www.webofscience.com/wos/woscc/full-record/WOS:000411769700013.
[47] Lu XiMing, Li Hui, You Jing, Li Wei, Wang PengYe, Li Ming, Xi XuGuang, Dou ShuoXing. An optimization algorithm for single-molecule fluorescence resonance (smFRET) data processing. ACTA PHYSICA SINICA[J]. 2017, 第 6 作者66(11): https://www.webofscience.com/wos/woscc/full-record/WOS:000403091100038.
[48] 马丽, 李颖, 李明, 胡书新. Protein-membrane interactions investigated with surface-induced fluorescence attenuation. 中国物理B：英文版[J]. 2017, 第 3 作者26(12): 62-67, http://lib.cqvip.com/Qikan/Article/Detail?id=673835545.
[49] Zhang YuWei, Yan Yan, Nong DaGuan, Xu ChunHua, Li Ming. Combination of magnetic tweezers with DNA hairpin as a potential approach to the study of RecA-mediated homologous recombination. ACTA PHYSICA SINICA[J]. 2016, 第 5 作者  通讯作者  65(21): https://www.webofscience.com/wos/woscc/full-record/WOS:000389597200035.
[50] Ying Li, Zhenyu Qian, Li Ma, Shuxin Hu, Daguan Nong, Chunhua Xu, Fangfu Ye, Ying Lu, Guanghong Wei, Ming Li. Single-molecule visualization of dynamic transitions of pore-forming peptides among multiple transmembrane positions. NATURE COMMUNICATIONS[J]. 2016, 第 10 作者  通讯作者  7(1): https://doaj.org/article/a28f4e82436648fabfc779dd0029fad1.
[51] Zhang, Bo, Wu, WenQiang, Liu, NaNv, Duan, XiaoLei, Li, Ming, Dou, ShuoXing, Hou, XiMiao, Xi, XuGuang. G-quadruplex and G-rich sequence stimulate Pif1p-catalyzed downstream duplex DNA unwinding through reducing waiting time at ss/dsDNA junction. NUCLEIC ACIDS RESEARCH[J]. 2016, 第 5 作者44(17): 8385-8394, https://www.webofscience.com/wos/woscc/full-record/WOS:000386158800035.
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[53] Zhang YuWei, Yan Yan, Nong DaGuan, Xu ChunHua, Li Ming. Combination of magnetic tweezers with DNA hairpin as a potential approach to the study of RecA-mediated homologous recombination. ACTA PHYSICA SINICA[J]. 2016, 第 5 作者  通讯作者  65(21): https://www.webofscience.com/wos/woscc/full-record/WOS:000389597200035.
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2000  中科院****
2003  国家杰出青年基金
2006  基金委面上项目
2006  中科院知识创新重要方向性项目
2006  蛋白质研究重大计划子课题之蛋白质折叠
2008  基金委面上项目 

用单分子操纵技术研究并阐述生物分子马达UvrD解旋酶的工作机理；用电化学协同自组装方法制备一系列有机-无机复合多层膜。
研究工作的主要特点是物理学与生命科学和材料化学的交叉。用物理学思维方式思考生命科学和材料化学的基础问题，用先进的物理技术检验并实现新奇的想法。