071009-细胞生物学
100104-病理学与病理生理学

细胞生物学-疾病易感基因识别和功能研究
病理学与病理生理学-疾病易感基因识别和功能研究

1983-09--1988-07   山东医科大学医学系   医学学士

   

2014-06~2016-10,中国科学院上海生命科学研究院上海交通大学医学院健康科学研究所, 副所长
2007-01~2007-07,Wellcome Trust/Cancer Research UK Gurdon Institute, Cambridge, UK, 访问学者
2004-01~2004-04,University of Bath, Bath, United Kingdom, 访问学者
2002-04~现在, 中国科学院上海营养与健康研究所, 研究员
2001-01~2001-04,The Forsyth Institute and Harvard School of Dental Medicine, 访问学者
1997-09~2002-06,中科院上海生物工程研究中心, 副研究员、研究员
1995-07~1997-09,Max-Planck Institute for Molecular Genetics, Germany, 访问学者
1988-09~1995-06,中国医学科学院血液学研究所, 研究实习员、助理研究员
1983-09~1988-07,山东医科大学医学系, 医学学士

2018-12-27-今,安达生物药物开发（深圳）有限公司, 首席科学家

   

（1） 药明康德生命化学研究奖, 二等奖, 其他, 2010
（2） 谈家桢生命科学奖创新奖, 三等奖, 其他, 2009
（3） 中国青年科技奖, 国家级, 2004
（4） 上海市自然科学牡丹奖, 市地级, 2004
（5） 热休克蛋白转录因子HSF4突变导致白内障, 一等奖, 市地级, 2003
（6） DSPP突变引起遗传性乳光牙本质Ⅰ型伴有或不伴有进行性高频耳聋, 二等奖, 市地级, 2002
（7） 遗传性乳光牙本质致病基因的研究, 二等奖, 国家级, 2002

（ 1 ） Baldness related gene and the polypeptide encoded thereby, and uses, 2009, 第 1 作者, 专利号: US7,554,485 B2

（ 2 ）  Method of Diagnosing and Treating Baldness Using Human and Mouse Rhor Gene and Coded Product Thereof, 2009, 第 1 作者, 专利号: 1566386

（ 3 ） Method of diagnosing and treating dentinogenesis imperfecta type II by using dentin sialophosphoprotein gene and coded product thereof, 2008, 第 1 作者, 专利号: US7,396,644 B2

（ 4 ） Method for diagnosing and treating dentinogenesis imperfecta type II by using dentin sialophosphoprotein (DSPP) gene and its encoding product, 2008, 第 1 作者, 专利号: EP1323427

（ 5 ） 人CYLD基因及其编码产物在制备诊断试剂中的用途, 2008, 第 1 作者, 专利号: ZL02110857.9

（ 6 ） 利用人和鼠Rhor基因及其编码产物诊断和治疗秃发的方法, 2007, 第 1 作者, 专利号: ZL02145253.9

（ 7 ） 牙本质唾磷蛋白基因及其编码产物在制备治疗牙本质生成不全II型的药物中的用途及检测牙本质生成不全II型的试剂盒, 2007, 第 1 作者, 专利号: ZL00125042.6

（ 8 ） 体外检测CRYGS基因及其编码产物是否存在突变的方法, 2006, 第 1 作者, 专利号: ZL00119756.8

   

（1） Global analysis of T-cell groups reveals immunological features and common antigen targets of digestive tract tumors, Global analysis of T-cell groups reveals immunological features and common antigen targets of digestive tract tumors, J Cancer Res Clin Oncol ., 2024, 
（2） Targeting Tumor Heterogeneity by Breaking a Stem Cell and Epithelial Niche Interaction Loop., Targeting Tumor Heterogeneity by Breaking a Stem Cell and Epithelial Niche Interaction Loop., Adv Sci (Weinh), 2024, 第 6 作者
（3） Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation., Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation., Nat Immunol., 2024, 第 12 作者
（4） Protocol for PPP1R15A-inhibited mouse model establishment with subcutaneous B16F1 tumor and single-cell analysis., Protocol for PPP1R15A-inhibited mouse model establishment with subcutaneous B16F1 tumor and single-cell analysis., STAR Protoc., 2023, 
（5） A novel long noncoding RNA SP100-AS1 induces radioresistance of colorectal cancer via sponging miR-622 and stabilizing ATG3., A novel long noncoding RNA SP100-AS1 induces radioresistance of colorectal cancer via sponging miR-622 and stabilizing ATG3., Cell Death Differ, 2023, 第 6 作者
（6） Single-cell RNA sequencing reveals the suppressive effect of PPP1R15A inhibitor Sephin1 in antitumor immunity., Single-cell RNA sequencing reveals the suppressive effect of PPP1R15A inhibitor Sephin1 in antitumor immunity., iScience, 2023, 
（7） Escaping but not the inactive X-linked protein complex coding genes may achieve X-chromosome dosage compensation and underlie X chromosome inactivation-related diseases., Escaping but not the inactive X-linked protein complex coding genes may achieve X-chromosome dosage compensation and underlie X chromosome inactivation-related diseases., Heliyon., 2023, 
（8） Remodeling of H3K9me3 during the pluripotent to totipotent-like state transition., Remodeling of H3K9me3 during the pluripotent to totipotent-like state transition., Stem Cell Reports., 2023, 第 12 作者
（9） Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral T reg cell differentiation, NATURE IMMUNOLOGY, 2023, 第 20 作者
（10） Targeting KRAS-mutant stomach/colorectal tumors by disrupting the ERK2-p53 complex., Targeting KRAS-mutant stomach/colorectal tumors by disrupting the ERK2-p53 complex., Cell Rep., 2023, 第 12 作者
（11） Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kα inhibitors., Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3K�� inhibitors., Signal Transduct Target Ther., 2023, 第 12 作者
（12） Longitudinal immune profiling reveals dominant epitopes mediating long-term humoral immunity in COVID-19-convalescent individuals., Longitudinal immune profiling reveals dominant epitopes mediating long-term humoral immunity in COVID-19-convalescent individuals., J Allergy Clin Immunol., 2022, 第 12 作者
（13） Genome-wide gain-of-function screening identifies EZH2 mediating resistance to PI3Kα inhibitors in oesophageal squamous cell carcinoma., Genome-wide gain-of-function screening identifies EZH2 mediating resistance to PI3K�� inhibitors in oesophageal squamous cell carcinoma., Clin Transl Med., 2022, 第 12 作者
（14） SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes., SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes., Adv Sci (Weinh), 2022, 第 12 作者
（15） Occludin is a target of Src kinase and promotes lipid secretion by binding to BTN1a1 and XOR., Occludin is a target of Src kinase and promotes lipid secretion by binding to BTN1a1 and XOR., PLoS Biol., 2022, 第 12 作者
（16） Characterization of the Blood and Cerebrospinal Fluid Microbiome in Children with Bacterial Meningitis and Its Potential Correlation with Inflammation., Characterization of the Blood and Cerebrospinal Fluid Microbiome in Children with Bacterial Meningitis and Its Potential Correlation with Inflammation., mSystems., 2021, 
（17） PI3Kα inhibitor CYH33 triggers antitumor immunity in murine breast cancer by activating CD8+T cells and promoting fatty acid metabolism., PI3K�� inhibitor CYH33 triggers antitumor immunity in murine breast cancer by activating CD8+T cells and promoting fatty acid metabolism., J Immunother Cancer, 2021, 
（18） Adaptive resistance to PI3Kα-selective inhibitor CYH33 is mediated by genomic and transcriptomic alterations in ESCC cells., Adaptive resistance to PI3K��-selective inhibitor CYH33 is mediated by genomic and transcriptomic alterations in ESCC cells., Cell Death Dis., 2021, 第 12 作者
（19） CST6 protein and peptides inhibit breast cancer bone metastasis by suppressing CTSB activity and osteoclastogenesis., CST6 protein and peptides inhibit breast cancer bone metastasis by suppressing CTSB activity and osteoclastogenesis., Theranostics., 2021, 第 12 作者
（20） Tumor microbiome contributes to an aggressive phenotype in the basal-like subtype of pancreatic cancer., Tumor microbiome contributes to an aggressive phenotype in the basal-like subtype of pancreatic cancer., Commun Biol., 2021, 
（21） Identification of Key Genes With Differential Correlations in Lung Adenocarcinoma., Identification of Key Genes With Differential Correlations in Lung Adenocarcinoma., Front Cell Dev Biol, 2021, 第 12 作者
（22） Brca2 deficiency drives gastrointestinal tumor formation and is selectively inhibited by mitomycin C., Brca2 deficiency drives gastrointestinal tumor formation and is selectively inhibited by mitomycin C., Cell Death Dis., 2020, 第 12 作者
（23） Natural Selection on Exonic SNPs Shapes Allelic Expression Imbalance (AEI) Adaptability in Lung Cancer Progression., Natural Selection on Exonic SNPs Shapes Allelic Expression Imbalance (AEI) Adaptability in Lung Cancer Progression., Front Genet., 2020, 
（24） Brca2 deficiency drives gastrointestinal tumor formation and is selectively inhibited by mitomycin C, CELL DEATH & DISEASE, 2020, 第 11 作者
（25） Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 第 12 作者
（26） Natural Selection on Exonic SNPs Shapes Allelic Expression Imbalance (AEI) Adaptability in Lung Cancer Progression, FRONTIERS IN GENETICS, 2020, 第 10 作者  通讯作者
（27） Identifying circulating miRNA biomarkers for early diagnosis and monitoring of lung cancer., Identifying circulating miRNA biomarkers for early diagnosis and monitoring of lung cancer., Biochim Biophys Acta Mol Basis Dis., 2020, 
（28） Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II., Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II., Proc Natl Acad Sci U S A., 2020, 第 12 作者
（29） ONECUT2 overexpression promotes RAS-driven lung adenocarcinoma progression, SCIENTIFIC REPORTS, 2019, 第 8 作者  通讯作者
（30） Sex-related DNA methylation differences in B cell chronic lymphocytic leukemia, BIOLOGY OF SEX DIFFERENCES, 2019, 第 5 作者
（31） A computational method using the random walk with restart algorithm for identifying novel epigenetic factors, MOLECULAR GENETICS AND GENOMICS, 2018, 第 5 作者  通讯作者
（32） Distinguishing three subtypes of hematopoietic cells based on gene expression profiles using a support vector machine, BBA - MOLECULAR BASIS OF DISEASE, 2018, 第 5 作者
（33） Distinguishing three subtypes of hematopoietic cells based on gene expression profiles using a support vector machine, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2018, 第 5 作者  通讯作者
（34） Identification of the core regulators of the HLA I-peptide binding process, SCIENTIFIC REPORTS, 2017, 第 7 作者  通讯作者
（35） Identifying and analyzing different cancer subtypes using rna-seq data of blood platelets, ONCOTARGET, 2017, 第 8 作者  通讯作者
（36） Identifying New Candidate Genes and Chemicals Related to Prostate Cancer Using a Hybrid Network and Shortest Path Approach, COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE, 2015, 第 7 作者  通讯作者
（37） Genome-Wide Association Studies of HIV-1 Host Control in Ethnically Diverse Chinese Populations, SCIENTIFIC REPORTS, 2015, 第 14 作者
（38） Integrative Analysis Reveals Enhanced Regulatory Effects of Human Long Intergenic Non-Coding RNAs in Lung Adenocarcinoma, JOURNAL OF GENETICS AND GENOMICS, 2015, 第 12 作者
（39） Identifying Novel Candidate Genes Related to Apoptosis from a Protein-Protein Interaction Network, HINDAWI PUBLISHING CORPORATION, 2015, 第 1 作者
（40） Alternative splicing at GYNNGY 5��� splice sites: more noise, less regulation, NUCLEIC ACIDS RESEARCH, 2014, 第 10 作者  通讯作者
（41） COL4A3 mutations cause focal segmental glomerulosclerosis, JOURNAL OF MOLECULAR CELL BIOLOGY, 2014, 第 14 作者
（42） Exome sequencing identifies frequent mutation of MLL2 in non���small cell lung carcinoma from Chinese patients, SCIENTIFIC REPORTS, 2014, 第 15 作者
（43） Genes That Escape X-Inactivation in Humans Have High Intraspecific Variability in Expression, Are Associated with Mental Impairment but Are Not Slow Evolving, MOLECULAR BIOLOGY AND EVOLUTION, 2013, 第 11 作者
（44） Identification of Two Maternal Transmission Ratio Distortion Loci in Pedigrees of the Framingham Heart Study, SCIENTIFIC REPORTS, 2013, 第 6 作者  通讯作者
（45） Genome-Wide Interaction-Based Association Analysis Identified Multiple New Susceptibility Loci for Common Diseases, PLOS GENETICS, 2011, 第 11 作者
（46） SKAP2, a novel target of HSF4b, associates with NCK2/F-actin at membrane ruffles and regulates actin reorganization in lens cell, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2011, 第 8 作者
（47） Evidence for OTUD-6B Participation in B Lymphocytes Cell Cycle after Cytokine Stimulation, PLOS ONE, 2011, 第 4 作者
（48） Nonsense-mediated decay targets have multiple sequence-related features that can inhibit translation, MOLECULAR SYSTEMS BIOLOGY, 2010, 第 9 作者  通讯作者
（49） Predicting Drug-Target Interaction Networks Based on Functional Groups and Biological Features, PLOS ONE, 2010, 第 5 作者
（50） Length of the ORF, position of the first AUG and the Kozak motif are important factors in potential dual-coding transcripts, Length of the ORF, position of the first AUG and the Kozak motif are important factors in potential dual-coding transcripts, 细胞研究：英文版, 2010, 第 14 作者
（51） Loss-of-Function Mutations in the PRPS1 Gene Cause a Type of Nonsyndromic X-linked Sensorineural Deafness, DFN2, AMERICAN JOURNAL OF HUMAN GENETICS, 2010, 第 11 作者
（52） Identification of vimentin as a novel target of hsf4 in lens development and cataract by proteomic analysis, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2010, 第 7 作者
（53） Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury, LABORATORY INVESTIGATION, 2009, 第 9 作者
（54） Gain-of-Function Mutation of KIT Ligand on Melanin Synthesis Causes Familial Progressive Hyperpigmentation, AMERICANJOURNALOFHUMANGENETICS, 2009, 第 15 作者  通讯作者
（55） Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay, BMC BIOLOGY, 2009, 第 6 作者  通讯作者
（56） Dosage compensation on the active X chromosome minimizes transcriptional noise of X-linked genes in mammals, GENOME BIOLOGY, 2009, 第 7 作者
（57） Divergence of exonic splicing elements after gene duplication and the impact on gene structures, GENOME BIOLOGY, 2009, 第 7 作者  通讯作者
（58） Removal of Hsf4 leads to cataract development in mice through down-regulation of gamma S-crystallin and Bfsp expression, BMC MOLECULAR BIOLOGY, 2009, 第 8 作者  通讯作者
（59） Triphalangeal thumb-polysyndactyly syndrome and syndactyly type IV are caused by genomic duplications involving the long range, limb-specific SHH enhancer, JOURNAL OF MEDICAL GENETICS, 2008, 
（60） Alternative Promoters Influence Alternative Splicing at the Genomic Level, PLOS ONE, 2008, 第 3 作者
（61） Evidence for common short natural trans sense-antisense pairing between transcripts from protein coding genes, GENOME BIOLOGY, 2008, 第 6 作者  通讯作者
（62） Activation of paternally expressed imprinted genes in newly derived germline-competent mouse parthenogenetic embryonic stem cell lines, CELL RESEARCH, 2007, 第 8 作者
（63） Association of IL4R gene polymorphisms with asthma in Chinese populations, Hum Mutat, 2007, 第 1 作者  通讯作者
（64） Temporal and parental-specific expression of imprinted genes in a newly derived Chinese human embryonic stem cell line and embryoid bodies, HUMAN MOLECULAR GENETICS, 2006, 
（65） Simple sequence repeat-based consensus linkage map of Bombyx mori, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 
（66） Epigenetic inactivation of DLC-1 in supratentorial primitive neuroectodermal tumor, HUMAN PATHOLOGY, 2005, 
（67） CYLD Mutation Causes Multiple Familial Trichoepithelioma in Three Chinese Families, HUMAN MUTATION, 2004, 第 10 作者  通讯作者
（68） Molecular evolution of the sars coronavirus during the course of the sars epidemic in china, SCIENCE, 2004, 
（69） Embryonic stem cells generated by nuclear transfer of human somaticnuclei into rabbit oocytes, Embryonic stem cells generated by nuclear transfer of human somatic nuclei into rabbit oocytes, CELL RESEARCH, 2003, 
（70） Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract, NATURE GENETICS, 2002, 
（71） Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP (vol 27, pg 201, 2001), NATURE GENETICS, 2001, 

   

（ 1 ） 肿瘤疫苗介导的肿瘤杀伤调控机制研究, 负责人, 中国科学院计划, 2024-01--2026-12
（ 2 ） 孔祥银组横向项目企业, 负责人, 境内委托项目, 2020-11--2030-12
（ 3 ） 组织干细胞突变的形成和演化规律研究, 负责人, 国家任务, 2017-07--2021-12
（ 4 ） 组织干细胞突变的形成和演化规律研究, 负责人, 国家任务, 2017-07--2023-12
（ 5 ） 人类基因组疾病易感变异的系统性研究, 负责人, 中国科学院计划, 2016-08--2020-12
（ 6 ） 药物分层的系统生物学研究, 参与, 中国科学院计划, 2015-10--2020-09
（ 7 ） 无义介导降解机制的新靶标——非编码转录本, 负责人, 国家任务, 2015-01--2018-12

（1）Systematic analysis of GYNNGY donor splicing sites in humans and mice   2014-10-08
（2）New insights into the functional diversity of mRNA   第三届中英癌症生物学前沿研讨会：暨MRC-中国上海“细胞死亡，干细胞与癌症”国际研讨会   2013-05-08