基本信息
李川  男  博导  中国科学院上海药物研究所
电子邮件: chli@simm.ac.cn
通信地址: 上海市张江高科技园区海科路501号1号楼502室
邮政编码: 201203

招生信息

   
招生专业
100706-药理学
100800-中药学
招生方向
药代动力学
临床中药学

教育背景

1995-05--1998-04   日本 - 东京药科大学药学部   博士
1982-09--1986-07   成都中医学院(现:成都中医药大学)   医学学士

工作经历

   
工作简历
2000-12~现在, 中国科学院上海药物研究所, 研究员、课题组长
1998-05~2000-11,美国 - 新泽西州立大学药学院, 博士后
1995-05~1998-04,日本 - 东京药科大学药学部, 博士
1986-08~1995-03,中国中医研究院中药研究所(现:中国中医科学院中药研究所), 助理研究员
1982-09~1986-07,成都中医学院(现:成都中医药大学), 医学学士
社会兼职
2016-12-01-今,中国药理学会专业委员会, 副主任委员
2009-03-01-今,天津中医药大学兼职博士生导师,

教授课程

药代动力学概论及 新药研发中的药代研究
中药药代动力学研究

专利与奖励

   
奖励信息
(1) “银杏酮酯原料及制剂、人工麝香原料还可苏I、II”的产学研二次开发, 一等奖, 省级, 2015
(2) 中国中医科学院唐氏中医药发展奖(中药研究青年奖), 院级, 2014
(3) 治疗代谢性疾病的中药新药发现与评价关键技术研究及应用, 一等奖, 省级, 2010
(4) 药明康德生命化学研究奖, 一等奖, 其他, 2008
(5) 液相色谱电解质效应的发现及液-质联用技术分析中药多成分复杂样品方法学研究, 三等奖, 省级, 2007
专利成果
( 1 ) 一种银杏叶原料及制剂中烷基酚类化合物的检测方法, 2016, 第 1 作者, 专利号: ZL201410705090.4

( 2 ) 一种测定人或动物全血中喜明替康和吉咪替康含量的方法, 2010, 第 3 作者, 专利号: 201010260758.0

出版信息

   
发表论文
(1) Pharmacokinetics-Based Identification of Potential Therapeutic Phthalides from XueBiJing, a Chinese Herbal Injection Used in Sepsis Management, Drug Metabolism and Disposition, 2018, 通讯作者
(2) Glycyrrhizin has a high likelihood to be a victim of drug interactions mediated by hepatic OATP1B1/1B3, British Journal of Pharmacology, 2018, 通讯作者
(3) 中药多成分药代动力学研究:思路与方法, Multi-compound pharmacokinetic research on Chinese herbal medicines: approach and methodology, 中国中药杂志, 2017, 通讯作者
(4) Pharmacokinetics of catechols in human subjects intravenously receiving XueBiJing injection, an emerging antiseptic herbal medicine., Drug Metab. Pharmacokinet., 2016, 通讯作者
(5) Pharmacokinetics and disposition of monoterpene glycosides derived from Paeonia lactiflora roots (Chishao) after intravenous dosing of antiseptic XueBiJing injection in human subjects and rats., Acta Pharmacol. Sin., 2016, 通讯作者
(6) Mass spectrometry imaging: applications in drug distribution studies., Curr. Drug Metab., 2015, 第 2 作者
(7) Methylation and its role in disposition of tanshinol, a cardiovascular carboxylic catechol from salvia miltiorrhiza roots (Danshen)., Acta Pharmacol. Sin., 2015, 通讯作者
(8) Systemic exposure to and disposition of catechols, derived from Salvia miltiorrhiza roots (Danshen), after intravenous dosing DanHong injection in human subjects, rats, and dogs., Drug Metab. Dispos., 2015, 通讯作者
(9) Renal tubular secretion of tanshinol: molecular mechanisms, impact on its systemic exposure, and propensity for dose-related nephrotoxicity and for renal herb-drug interactions., Drug Metab. Dispos., 2015, 通讯作者
(10) Molecular mechanisms governing different pharmacokinetics of ginsenosides and potential for ginsenoside-perpetrated herb-drug interactions on OATP1B3., Br. J. Pharmacol., 2015, 通讯作者
(11) Combinatorial metabolism notably affects human systemic exposure to ginsenosides from orally administered extract of Panax notoginseng roots (Sanqi)., Drug Metab. Dispos., 2013, 通讯作者
(12) Sensitive assay for measurement of volatile borneol, isoborneol, and the metabolite camphor in rat pharmacokinetic study of Borneolum (Bingpian) and Borneolum syntheticum (synthetic Bingpian)., Acta Pharmacol. Sin., 2013, 通讯作者
(13) Systemic and cerebral exposure to and pharmacokinetics of flavonols and terpene lactones after dosing standardized Ginkgo biloba leaf extracts to rats via different administration routes., Br. J. Pharmacol., 2013, 通讯作者
(14) Absorption and disposition of saponins: what do we know and what do we need to know?, Curr. Drug Metab., 2012, 通讯作者
(15) Intestinal absorption and presystemic elimination of various chemical constituents present in GBE50 extract, a standardized extract of Ginkgo biloba leaves., Curr. Drug Metab., 2012, 通讯作者
(16) Editorial: absorption, disposition, and pharmacokinetics of herbal medicines: what and how?, Curr. Drug Metab., 2012, 通讯作者
(17) Nebulizing conditions of pneumatic electrospray ionization significantly influence electrolyte effects on compound measurement., J. Mass Spectrom., 2012, 通讯作者
(18) Metabolic capabilities of cytochrome P450s in Chinese liver microsomes compared with those in Caucasian liver microsomes., Br. J. Clin. Pharmacol., 2012, 通讯作者
(19) Accurate determination of the anticancer prodrug simmitecan and its active metabolite chimmitecan in various plasma samples based on immediate deactivation of blood carboxylesterases., J. Chromatogr. A, 2011, 通讯作者
(20) Oral bioavailability and brain penetration of (?)-stepholidine, a tetrahydroprotoberberine agonist at dopamine D1 and antagonist at D2 receptors, in rats., Br. J. Pharmacol., 2009, 通讯作者
(21) 1,4-Diamino-2,3-dicyano-1,4- bis(methylthio)butadiene (U0126) enhances the cytotoxicity of combretastatin A4 independently of mitogen-activated protein kinase., J. Pharmacol. Exp. Ther., 2009, 第 3 作者
(22) Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats., Drug Metab. Dispos., 2009, 通讯作者
(23) Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu-tang across human intestinal Caco-2 cell monolayers., Acta Pharmacol. Sin., 2008, 通讯作者
(24) Plasma and urinary tanshinol from Salvia Miltiorrhiza (Danshen), can be used as pharmacokinetic markers for Cardiotonic pills, a cardiovascular herbal medicine., Drug Metab. Dispos., 2008, 通讯作者
(25) Pulse gradient, large-volume injection, high-throughput ultra-performance liquid chromatographic/tandem mass spectrometry bioanalysis for measurement of plasma amrubicin and its metabolite amrubicinol. , J. Chromatogr. A, 2008, 通讯作者
(26) Simultaneous determination of ginkgo flavonoids and terpenoids in plasma: ammonium formate in LC mobile phase enhancing electrospray ionization efficiency and capacity. , J. Am. Soc. Mass Spectrom. , 2008, 通讯作者
(27)  ‘LC-electrolyte effects’ improve the bioanalytical performance of liquid chromatography/tandem mass spectrometric assays in supporting drug discovery pharmacokinetic study. , Rapid Commun. Mass Spectrom. , 2007, 通讯作者
(28) Comparative metabolic capabilities and inhibitor profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17. , Drug Metab. Dispos., 2007, 通讯作者
(29) A sensitive method for the detection and quantification of ginkgo flavonols from plasma. , Rapid Commun. Mass Spectrom. , 2007, 通讯作者
(30) Simultaneous quantification of multiple licorice flavonoids in rat plasma. , J. Am. Soc. Mass Spectrom. , 2007, 通讯作者
(31) Design and synthesis of novel bis(l-amino acid) ester prodrugs of 9-[2- (phosphonomethoxy)ethyl]adenine (PMEA) with improved anti-HBV activity., Bioorg. Med. Chem. Lett., 2007, 第 3 作者
(32) Characterization and quantification of eight water-soluble constituents in tubers of Pinellia ternata and in tea granules from the Chinese multiherb remedy Xiaochaihu-tang. , J. Chromatogr. B, 2006, 通讯作者
(33) Rapid and direct measurement of free concentrations of highly protein-bound fluoxetine and its metabolite norfluoxetine in plasma. , Rapid Commun. Mass Spectrom., 2006, 通讯作者
(34) Study of inhibition of six new drugs on five human cytochrome P450 isozymes in vitro system., Asian J. Pharmacodynam. Pharmacokinet., 2006, 第 3 作者
(35) A new method for measurement of (–)-sophocarpine, a candidate therapeutic for viral myocarditis, in plasma: application to a toxicokinetic study in beagle dogs. , Rapid Commun. Mass Spectrom. , 2005, 通讯作者
(36) Determination of saikosaponin derivatives in Radix bupleuri and in pharmaceuticals of the Chinese multiherb remedy Xiaochaihu-tang using liquid chromatographic tandem mass spectrometry. , Anal. Chem. , 2004, 通讯作者
(37) Liquid chromatography-nuclear magnetic resonance spectroscopy and its applications in drug metabolism studies. , Asian J. Drug Metab. Pharmacokinet., 2004, 通讯作者
(38) A sensitive method for the determination of the novel cholinesterase inhibitor ZT-1 and its active metabolite huperzine A in rat blood using liquid chromatography/tandem mass spectrometry., Rapid Commun. Mass Spectrom., 2004, 通讯作者
(39) Glucuronides of tea catechines: enzymology of biosynthesis and biological activities., Drug Metab. Dispos., 2003, 第 3 作者
(40) Liquid chromatography/tandem mass spectrometry for the determination of fluoxetine and its main active metabolite norfluoxetine in human plasma with deuterated fluoxetine as internal standard., Rapid Commun. Mass Spectrom., 2002, 通讯作者
发表著作
( 1 ) 《药物化学进展》第三章 新药发现阶段的药代研究, 化学工业出版社, 2005-01, 第 1 作者
( 2 ) 中药现代化二十年, 上海科学技术出版社, 2016-10, 第 3 作者

科研活动

   
科研项目
( 1 ) 组分配伍体内药代动力学研究, 负责人, 国家任务, 2012-01--2016-08
( 2 ) 银杏酮酯及其制剂生产过程的质量变化及临床药代动力学研究, 负责人, 地方任务, 2013-10--2017-09
( 3 ) 血必净注射液药代动力学及药效物质基础研究, 负责人, 企业委托, 2012-01--2017-12
( 4 ) 连花清瘟胶囊药代动力学研究, 负责人, 企业委托, 2016-05--2019-04
( 5 ) 化药I类创新药XY03-EA非临床药代动力学研究, 负责人, 企业委托, 2015-12--2017-06
( 6 ) 复方丹参方在人体内的暴露物质与其抗心绞痛作用关联研究, 负责人, 国家任务, 2017-01--2020-12
参与会议
(1)Roles of the herbal medicines in Drug interactions: the perpetrator or the victim   第6届APISSX   2018-05-12
(2)Pharmacokinetic Herb-Herb and Herb-Drug Interactions: Studies on Fufang-Danshen Formula, A Three-Herb Combination for Management of Angina Pectoris   李川   2016-06-16
(3)Pharmacokinetic research on XueBiJing injection, an antiseptic herbal medicine   李川   2016-02-03
(4)中药药代动力学及其在中药现代化研究中的作用——复方丹参方药代动力学研究   第201场中国工程科技论坛——先进制药技术发展论坛   李川   2015-04-27
(5)丹红注射液药代动力学研究   第五届全国中西医结合脑心同治学术交流会暨第一届国际脑心同治高峰论坛   李川   2015-04-11
(6)ADME/PK of tanshinol and associated herb-drug interaction potential   李川   2014-05-11
(7)Pharmacokinetic Studies of Herbal Injections   2013年第一届岭南国际DMPK论坛   李川   2013-12-06
(8)Multicompound Pharmacokinetic Studies of Pharmaceuticals of Ginkgo biloba Leaf Extract in Rats   2013韩中传统医药研讨会   李川   2013-11-19
(9)ADME/PK Studies of Herbal Medicines and What We Learned From Them   李川   2013-10-01
(10)不同给药途径下银杏黄酮醇类和内酯类成分在大鼠体内的系统暴露和脑暴露特征研究   第四届中医药现代化国际科技大会   李川   2013-09-26
(11)中药药代动力学研究方法和关键技术   香山科学会议(第418次学术讨论会–组分中药研讨会)   李川   2012-03-22