基本信息
王贺瑶  女  博导  中国科学院上海药物研究所
电子邮件: hywang@simm.ac.cn
通信地址: 上海浦东新区祖冲之路555号
邮政编码: 201203

招生信息

   
招生专业
100706-药理学
招生方向
代谢内分泌药理学

教育背景

1992-04--1997-03   日本神户大学医学研究科   博士

工作经历

   
工作简历
2005-04~现在, 中国科学院上海药物研究所, 课题组长/研究员
2002-04~2005-03,日本国立国际医疗中心, 研究员
1997-08~2002-03,日本千叶大学, 研究员
1992-04~1997-03,日本神户大学医学研究科, 博士
社会兼职
2010-11-24-今,上海市科技系统少数民族联合会, 副理事长

专利与奖励

   
奖励信息
(1) 桂皮中低聚原花青素类化学成分及其降血糖活性成分研究, 三等奖, 市地级, 2014
专利成果
( 1 ) 一类溴代不饱和脂肪酸酯的合成新方法, 2018, 第 2 作者, 专利号: ZL 2014 1 0235574.7

( 2 ) 磺酰胺类化合物及其在制备治疗糖尿病的药物中的用途, 2016, 第 2 作者, 专利号: 201610989682.2

( 3 ) 一种噻吩丙酸类化合物、其药物组合物、制备方法和用途, 2016, 第 3 作者, 专利号: 201610140007.2

( 4 ) 溴化烯炔类化合物及其制备方法和用途, 2016, 第 1 作者, 专利号: ZL 2014 1 0268413.8

( 5 ) 溴化烯炔类化合物及其制备方法和用途, 2016, 第 1 作者, 专利号: ZL 2014 1 0268413.8

( 6 ) 一类4,5-二取代咪唑衍生物及其制备方法和用途, 2015, 第 3 作者, 专利号: 201510960383.1

( 7 ) 溴化烯炔化合物E-18-溴-5,7,15-三炔-17-烯十八酸酯的制备方法, 2015, 第 2 作者, 专利号: ZL 2012 1 0347339.X

( 8 ) 溴化烯炔化合物E,E-22-溴-9,11,19-三炔-17,21-二烯二十二酸酯合成方法, 2015, 第 2 作者, 专利号: ZL 2012 1 0345768.3

( 9 ) 苯丙酸类衍生物的合成和用途, 2015, 第 2 作者, 专利号: 201510500222.4

( 10 ) 蜂斗菜酚化合物在制备酪氨酸酶抑制剂中的应用, 2015, 第 5 作者, 专利号: ZL201210193531.8

( 11 ) 取代的酰肼类化合物及其制备方法、药物组合和用途, 2015, 第 3 作者, 专利号: ZL201110124762.9

( 12 ) 联杂芳基羧酸类化合物、其制备方法,包含该化合物的药物组合物、及用途, 2015, 第 2 作者, 专利号: ZL201110108003.3

( 13 ) 溴化烯炔类化合物及其制备方法和用途, 2014, 第 1 作者, 专利号: ZL201110180360.0

( 14 ) 一类2,4,6-三异丙基苯类化合物在制备治疗糖尿病的药物中的用途, 2014, 第 1 作者, 专利号: ZL201110310346.8

( 15 ) 4-羟基水杨酰苯胺化合物在制备酪氨酸酶抑制剂中的应用, 2014, 第 1 作者, 专利号: 201410707460.8

( 16 ) 异戊烯基黄酮化合物及其在制备胰脂肪酶抑制剂中的用途, 2014, 第 2 作者, 专利号: ZL201110137006.X

( 17 ) 连钱草提取物、制备方法及其用于降糖减肥降脂的用途, 2014, 第 2 作者, 专利号: 201410104913.9

( 18 ) 连钱草提取物、制备方法及其用于降糖减肥降脂的用途, 2014, 第 2 作者, 专利号: 201410104913.9

( 19 ) β-氨基羟基类化合物、其制备方法、药物组合物及其用途, 2013, 第 3 作者, 专利号: 201310090905.X

( 20 ) 黄酮类化合物在制备抗代谢性疾病药物中的用途, 2013, 第 2 作者, 专利号: ZL201110001869.4

( 21 ) 一种具有胰脂肪酶抑制活性的苯并大环内酯类化合物及其合成方法和用途, 2013, 第 2 作者, 专利号: ZL200910201463.3

( 22 ) 月桂烷型倍半萜类化合物或其衍生物、及其制备方法和用途, 2013, 第 2 作者, 专利号: ZL200810040588.8

( 23 ) 苯并大环内酯类化合物(3R)-去-O-甲基毛狄泼老素、其衍生物及其制备方法和用途, 2012, 第 1 作者, 专利号: ZL200810200074.4

( 24 ) 化合物(E)–5–[6–羟基–5–(3–甲基–1–丁烯基)–2–苯并呋喃基] 苯–1,3–二醇在制备胰脂肪酶抑制剂中的用途, 2012, 第 2 作者, 专利号: ZL200910047608.9

( 25 ) 一种从黑桑中提取的化合物作为酪氨酸酶抑制剂的用途, 2012, 第 1 作者, 专利号: ZL200710171483.1

( 26 ) 光叶桂木提取物及其用途, 2012, 第 2 作者, 专利号: 200910047607.4

( 27 ) 一种白桂木提取物及其制备方法和用途, 2011, 第 1 作者, 专利号: ZL201010022635.3

( 28 ) 一种从黑桑中提取的化合物在制备酪氨酸酶抑制剂中的应用, 2011, 第 1 作者, 专利号: ZL200710171484.6

( 29 ) 异戊烯基黄酮化合物作为胰脂肪酶抑制剂的用途, 2011, 第 1 作者, 专利号: ZL200910047752.2

( 30 ) 一种呋喃香豆素类衍生物及其制备方法和用途, 2011, 第 2 作者, 专利号: 201110028966.2

( 31 ) 取代磺酰胺类化合物及其制备方法、药物组合物和应用, 2009, 第 1 作者, 专利号: 200910046727.2

出版信息

   
发表论文
(1) Optimization of potent, selective and orally bioavailable biphenyl scaffold as FABP4 inhibitors for anti-inflammation, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 第 7 作者
(2) Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L., CHEMISTRY & BIODIVERSITY, 2021, 通讯作者
(3) DGAT1 inhibitors protect pancreatic β-cells from palmitic acid-induced apoptosis, DGAT1 inhibitors protect pancreatic β-cells from palmitic acid-induced apoptosis, 中国药理学报:英文版, 2021, 第 7 作者
(4) A novel low systemic diacylglycerol acyltransferase 1 inhibitor, Yhhu2407, improves lipid metabolism, EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021, 通讯作者
(5) A novel GPR120-selective agonist promotes insulin secretion and improves chronic inflammation, LIFE SCIENCES, 2021, 通讯作者
(6) A novel GPR120-selective agonist promotes insulin secretion and improves chronic inflammation, LIFE SCIENCES, 2021, 通讯作者
(7) Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 通讯作者
(8) Combined treatment with FABP4 inhibitor ameliorates rosiglitazone-induced liver steatosis in obese diabetic db/db mice, BASICCLINICALPHARMACOLOGYTOXICOLOGY, 2021, 通讯作者
(9) DGAT1 inhibitors protect pancreatic β-cells from palmitic acid-induced apoptosis, ACTA PHARMACOLOGICA SINICA, 2020, 第 7 作者
(10) DGAT1 inhibitors protect pancreatic beta-cells from palmitic acid-induced apoptosis, ACTA PHARMACOLOGICA SINICA, 2020, 通讯作者
(11) Cinnamtannin D1 Protects Pancreatic beta-Cells from Glucolipotoxicity-Induced Apoptosis by Enhancement of Autophagy In Vitro and In Vivo, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2020, 通讯作者
(12) Exogenous FABP4 interferes with differentiation, promotes lipolysis and inflammation in adipocytes, ENDOCRINE, 2020, 通讯作者
(13) Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice, JOURNAL OF ENDOCRINOLOGY, 2019, 第 10 作者
(14) Procyanidin C1, a Component of Cinnamon Extracts, Is a Potential Insulin Sensitizer That Targets Adipocytes, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 通讯作者
(15) Corrigendum to "From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4" Ejmech 154 (2018) 44–59, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 其他(合作组作者)
(16) From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4 (vol 154, pg 44, 2018), EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 通讯作者
(17) Identification of new dual FABP4/5 inhibitors based on a naphthalene-1-sulfonamide FABP4 inhibitor, BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 通讯作者
(18) Discovery of novel selective GPR120 agonists with potent anti-diabetic activity by hybrid design, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 通讯作者
(19) Isoprenylated phenolic compounds with tyrosinase inhibition from Morus nigra, JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2018, 第 4 作者
(20) Benzbromarone aggravates hepatic steatosis in obese individuals, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2018, 通讯作者
(21) 交泰丸中小檗碱联合cinnamtannin D1的降血糖作用, Synergistic anti-hyperglycemia effects of berberine and cinnamtannin D1 in Jiao-tai Pills, 中成药, 2018, 第 6 作者
(22) From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 通讯作者
(23) Benzbromarone aggravates hepatic steatosis in obese individuals, BBA - MOLECULAR BASIS OF DISEASE, 2018, 第 8 作者
(24) Isolation, identification and bioactivities of abietane diterpenoids from Premna szemaoensis, RSC ADVANCES, 2018, 通讯作者
(25) Enhancement of Berberine Hypoglycemic Activity by Oligomeric Proanthocyanidins, MOLECULES, 2018, 通讯作者
(26) 5,4 '-Dihydroxy-7,8-dimethoxyflavanone and Aliarin from Dodonaea viscosa Are Activators of PPAR gamma, PLANTA MEDICA, 2018, 通讯作者
(27) Sanggenol F exerts anti-diabetic effects via promoting adipocyte differentiation and modifying adipokines expression, ENDOCRINE, 2017, 通讯作者
(28) New Bicyclic Cembranoids from the South China Sea Soft Coral Sarcophyton trocheliophorum, SCIENTIFIC REPORTS, 2017, 第 4 作者
(29) Docking-based structural splicing and reassembly strategy to develop novel deazapurine derivatives as potent B-Raf V600E inhibitors, ACTA PHARMACOLOGICA SINICA, 2017, 通讯作者
(30) Combined Virtual Screening and Substructure Search for Discovery of Novel FABP4 Inhibitors, JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2017, 通讯作者
(31) Discovery of potent and orally bioavailable gpr40 full agonists bearing thiophen-2-ylpropanoic acid scaffold, JOURNAL OF MEDICINAL CHEMISTRY, 2017, 通讯作者
(32) Further brominated polyacetylenes with pancreatic lipase inhibitory activity from Chinese marine sponge Xestospongia testudinaria, JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2017, 通讯作者
(33) Sarcophytrols G - L, Novel Minor Metabolic Components from South China Sea Soft Coral Sarcophyton trocheliophorum MARENZELLER, CHEMISTRY & BIODIVERSITY, 2017, 第 5 作者
(34) A Novel Sarsolenane Diterpene as a PTP1B Inhibitor from Hainan Soft Coral Sarcophyton trocheliophorum Marenzeller, CHINESE JOURNAL OF CHEMISTRY, 2017, 第 7 作者
(35) Ginsenoside Rb2 Alleviates Hepatic Lipid Accumulation by Restoring Autophagy via Induction of Sirt1 and Activation of AMPK, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 通讯作者
(36) Discovery of a low-systemic-exposure DGAT-1 inhibitor with a picolinoylpyrrolidine-2-carboxylic acid moiety, BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 通讯作者
(37) Ginsenoside Rb2 enhances the anti-inflammatory effect of ω-3 fatty acid in LPS-stimulated RAW264.7 macrophages by upregulating GPR120 expression, ACTA PHARMACOLOGICA SINICA, 2017, 第 3 作者
(38) Ginsenoside Rb2 enhances the anti-inflammatory effect of omega-3 fatty acid in LPS-stimulated RAW264.7 macrophages by upregulating GPR120 expression, ACTA PHARMACOLOGICA SINICA, 2017, 通讯作者
(39) Further brominated polyacetylenes with pancreatic lipase inhibitory activity from Chinese marine sponge Xestospongia testudinaria, JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2017, 通讯作者
(40) Synthesis and Evaluation of Pancreatic Lipase Inhibitory Effects Halogenated Polyunsaturated Lipids from Marine Natural Products: Methyl Xestospongoate and Analogs, HELVETICA CHIMICA ACTA, 2016, 通讯作者
(41) Repositioning organohalogen drugs: a case study for identification of potent B-Raf V600E inhibitors via docking and bioassay, SCIENTIFIC REPORTS, 2016, 通讯作者
(42) First Total Synthesis of the Marine Natural Brominated Polyunsaturated Lipid Xestospongenyne as a Potent Pancreatic Lipase Inhibitory Agent, SYNLETT, 2016, 第 2 作者
(43) New Alkaloids and alpha-Glucosidase Inhibitory Flavonoids from Ficus hispida, CHEMISTRY & BIODIVERSITY, 2016, 第 4 作者
(44) Preparation of Methylated Products of A-type Procyanidin Trimers in Cinnamon Bark and Their Protective Effects on Pancreatic beta-Cell, JOURNAL OF FOOD SCIENCE, 2016, 通讯作者
(45) Trimer procyanidin oligomers contribute to the protective effects of cinnamon extracts on pancreatic β-cells in vitro, ACTA PHARMACOLOGICA SINICA, 2016, 第 9 作者
(46) Trimer procyanidin oligomers contribute to the protective effects of cinnamon extracts on pancreatic beta-cells in vitro, ACTA PHARMACOLOGICA SINICA, 2016, 通讯作者
(47) Synthesis and Evaluation of Pancreatic Lipase Inhibitory Effects Halogenated Polyunsaturated Lipids from Marine Natural Products: Methyl Xestospongoate and Analogs, HELVETICA CHIMICA ACTA, 2016, 通讯作者
(48) Chlorogenic acid analogues from Gynura nepalensis protect H9c2 cardiomyoblasts against H_2O_2-induced apoptosis, ACTA PHARMACOLOGICA SINICA, 2016, 通讯作者
(49) (2S)-7,4 '-dihydroxy-8-prenylflavan stimulates adipogenesis and glucose uptake through p38MAPK pathway in 3T3-L1 cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 通讯作者
(50) Novel fatty acid binding protein 4 (FABP4) inhibitors: virtual screening, synthesis and crystal structure determination., EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 第 9 作者
(51) Inhibition of Calcium Influx Reduces Dysfunction and Apoptosis in Lipotoxic Pancreatic beta-Cells via Regulation of Endoplasmic Reticulum Stress, PLOS ONE, 2015, 通讯作者
(52) New Isoprenylated Phenolic Compounds from Morus laevigata, CHEMISTRY & BIODIVERSITY, 2015, 第 6 作者
(53) Inhibitory Effects of (2 ' R)-2 ',3 '-dihydro-2 '-(1-hydroxy-1-methylethyl)-2,6 '-bibenzofuran-6,4 '-diol on Mushroom Tyrosinase and Melanogenesis in B16-F10 Melanoma Cells, PHYTOTHERAPY RESEARCH, 2015, 通讯作者
(54) Design, Synthesis, and Pharmacological Evaluation of Highly Potent and Selective Dipeptidyl Peptidase-4 Inhibitors, ARCHIV DER PHARMAZIE, 2015, 第11作者
(55) Design, Synthesis, and Pharmacological Evaluation of Fused beta-Homophenylalanine Derivatives as Potent DPP-4 Inhibitors, ACS MEDICINAL CHEMISTRY LETTERS, 2015, 第 13 作者
(56) Brominated polyunsaturated lipids from the Chinese sponge Xestospongia testudinaria as a new class of pancreatic lipase inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 第 9 作者
(57) Aphadilactones A-D, Four Diterpenoid Dimers with DGAT Inhibitory and Antimalarial Activities from a Meliaceae Plant, JOURNAL OF ORGANIC CHEMISTRY, 2014, 第 10 作者
(58) Design, Synthesis, and Structure-Activity and Structure-Pharmacokinetic Relationship Studies of Novel 6,6,5 Tricyclic Fused Oxazolidinones Leading to the Discovery of a Potent, Selective, and Orally Bioavailable FXa Inhibitor, JOURNAL OF MEDICINAL CHEMISTRY, 2014, 第 6 作者
(59) Cinnamtannin D-1 Protects Pancreatic beta-Cells from Palmitic Acid-Induced Apoptosis by Attenuating Oxidative Stress, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2014, 第 8 作者
(60) Discovery of N-substituted 3-arylisoquinolone derivatives as antitumor agents originating from O-substituted 3-arylisoquinolines via 2,3 or 3,3 rearrangement, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 第 9 作者
(61) Triterpenoids and alpha-glucosidase inhibitory constituents from Salacia hainanensis, FITOTERAPIA, 2014, 第 5 作者
(62) DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice., PLOS ONE, 2013, 第 7 作者
(63) Overman rearrangement and Pomeranz–Fritsch reaction for the synthesis of benzoazepinoisoquinolones to discover novel antitumor agents, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 第 6 作者
(64) A concise synthesis of xestospongic acid methyl ester with pancreatic lipase inhibitory activity, JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2013, 第 2 作者
(65) Dodoviscin A Inhibits Melanogenesis in Mouse B16-F10 Melanoma Cells, PLANTA MEDICA, 2013, 通讯作者
(66) Benzbromarone, an old uricosuric drug, inhibits human fatty acid binding protein 4 in vitro and lowers the blood glucose level in db/db mice, ACTA PHARMACOLOGICA SINICA, 2013, 通讯作者
(67) DC260126: A Small-Molecule Antagonist of GPR40 that Protects against Pancreatic beta-Cells Dysfunction in db/db Mice, PLOS ONE, 2013, 第 7 作者
(68) PDE5 inhibitor promotes melanin synthesis through the PKG pathway in B16 melanoma cells, JOURNAL OF CELLULAR BIOCHEMISTRY, 2012, 通讯作者
(69) 2-Arylbenzofuran and tyrosinase inhibitory constituents of Morus notabilis, JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2012, 第 5 作者
(70) The essential role for aromatic cluster in the beta 3 adrenergic receptor, ACTA PHARMACOLOGICA SINICA, 2012, 通讯作者
(71) Combining pharmacophore, docking and substructure search approaches to identify and optimize novel B-RafV600E inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 通讯作者
(72) Diverse Mechanisms of Antidialbetic Effects of the Different Procyanidin Oligomer Types of Two Different Cinnamon Species on db/db Mice, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2012, 第 6 作者
(73) New Isoprenylated Flavones and Stilbene Derivative from Artocarpus hypargyreus, CHEMISTRY & BIODIVERSITY, 2012, 第 5 作者
(74) 2-Arylbenzofuran, Flavonoid, and Tyrosinase Inhibitory Constituents of Morus yunnanensis, JOURNAL OF NATURAL PRODUCTS, 2012, 第 6 作者
(75) Isoprenylated Flavonoid and Adipogenesis-Promoting Constituents of Dodonaea viscosa, JOURNAL OF NATURAL PRODUCTS, 2012, 第 4 作者
(76) Inhibition of GPR40 protects MIN6 beta cells from palmitate-induced ER stress and apoptosis, JOURNAL OF CELLULAR BIOCHEMISTRY, 2012, 通讯作者
(77) 5-羟色胺1A受体激动剂高通量筛选模型的建立, Establishment of high throughput screening system of 5-HT_(1A) receptor agonists, 中国药理学通报, 2012, 第 5 作者
(78) Isoprenylated Flavonoid and Adipogenesis-Promoting Constituents from Dodonaea Viscosa, Journal of Natural Products, 2012, 第 1 作者
(79) The essential role for aromatic cluster in the β3 adrenergic receptor, The essential role for aromatic cluster in the β3 adrenergic receptor, 中国药理学报:英文版, 2012, 第 6 作者
(80) Diverse Mechanisms of Antidiabetic Effects of the Different Procyanidin Oligomer Types of Two Different Cinnamon Species on db/db Mice, Journal of Agricultural and Food Chemistry, 2012, 通讯作者
(81) 基于靶标braf的抗肿瘤研究进展, 药学学报, 2012, 第 3 作者
(82) Classification of 5-HT 1A receptor agonists and antagonists using GA-SVM method, ACTA PHARMACOLOGICA SINICA, 2011, 第 5 作者
(83) New isoprenylated flavonoids and adipogenesis-promoting constituents from Morus notabilis, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 第 6 作者
(84) Computational screening for active compounds targeting protein sequences: methodology and experimental validation., JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2011, 第 3 作者
(85) 1H NMR-Based Metabonomic Analysis of Metabolic Changes of Serum and Liver in Zucker Obese Rats, ANALYTICALLETTERS, 2011, 第 3 作者
(86) Isoprenylated Flavonoids and Adipogenesis-Promoting Constituents from Morus nigra, JOURNAL OF NATURAL PRODUCTS, 2011, 通讯作者
(87) 糖耐康对肥胖Zucker大鼠血糖的影响及其机制, Antidiabetic effects of Tangnaikang on obese Zucker rats and the mechanism, 中西医结合学报, 2010, 第 7 作者
(88) 潜在的防治肥胖及糖尿病靶标——DGAT, DGAT:a new target for prevention and treatment of obesity and diabetes, 生命科学, 2010, 第 4 作者
(89) A Metabonomic Comparison of Urinary Changes in Zucker and GK Rats, JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2010, 第 5 作者
(90) 三白草提取物对肥胖Zucker大鼠胰岛素抵抗的疗效观察, Study on Antidiabetic effects of Saururus Chinensis on obese Zucker rats, 中华中医药杂志, 2010, 第 6 作者
(91) Sildenafil promotes adipogenesis through a PKG pathway, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 通讯作者
(92) Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight gain, hyperlipidemia, and hepatic steatosis in db/db mice, ACTA PHARMACOLOGICA SINICA, 2010, 第 8 作者
(93) DC260126, a small-molecule antagonist of GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats, BIOMEDICINE & PHARMACOTHERAPY, 2010, 通讯作者
(94) Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 通讯作者
(95) A novel class of antagonists for the FFAs receptor GPR40, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 第 10 作者
(96) Berberine induces G1 arrest by regulating nuclear translocation of FoxO1 in hepatic stellate cells and prevents experimental liver fibrosis, Biological Pharmaceutical Bulletin, 2009, 通讯作者
(97) New Isoprenylated 2-Arylbenzofurans and Pancreatic Lipase Inhibitory Constituents from Artocarpus nitidus, CHEMISTRY & BIODIVERSITY, 2009, 通讯作者
(98) Effects of Pro-Arg, a Novel Dipeptide Derived from Protamine Hydrolysate on H2O2-Induced Oxidative Stress in Human Diploid Fibroblasts, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2009, 通讯作者
(99) Inhibition of hepatic stellate cell proliferation by heat shock protein 90 inhibitors in vitro, MOLECULARANDCELLULARBIOCHEMISTRY, 2009, 第 5 作者
(100) 糖尿病和动脉粥样硬化的潜在靶标——FABP4(aP2), A potential target for diabetes and atherosclerosis: FABP4(aP2), 生命科学, 2009, 第 5 作者
(101) Berberine Inhibits Hepatic Stellate Cell Proliferation and Prevents Experimental Liver Fibrosis, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2009, 通讯作者
(102) Inhibitory Effect of 2,4,2 ',4 '-Tetrahydroxy-3-(3-methyl-2-butenyl)-chalcone on Tyrosinase Activity and Melanin Biosynthesis, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2009, 第 4 作者
(103) GPR120的研究进展, Progress in GPR120 research, 生命科学, 2008, 第 4 作者
(104) Identification and functional analysis of CBLB mutations in type 1 diabetes, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 第 3 作者
(105) Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus, NATURE GENETICS, 2008, 第 13 作者
(106) Purification and characterization of antioxidative peptides from Salmon protamine hydrolysate, JOURNAL OF FOOD BIOCHEMISTRY, 2008, 通讯作者
(107) Genetic reconstitution of autoimmune type 1 diabetes with two major susceptibility genes in the rat, DIABETES, 2007, 第 4 作者
(108) Cblb is a major susceptibility gene for rat type 1 diabetes mellitus, NATURE GENETICS, 2002, 

科研活动

   
科研项目
( 1 ) 新型抗糖尿病药物靶标FABP4及其小分子抑制剂药理机制研究, 负责人, 国家任务, 2015-01--2018-12
( 2 ) 抑制钙信号减少脂肪酸引起的胰岛β细胞损伤及机制研究, 负责人, 地方任务, 2014-07--2017-06
( 3 ) 上海市中国西医结合临床重大项目(心力衰竭), 负责人, 地方任务, 2015-09--2017-09
( 4 ) 海洋来源溴化烯炔类胰脂肪酶抑制剂成药性研究, 参与, 地方任务, 2015-07--2018-06
( 5 ) 海洋来源溴化烯炔类胰脂肪酶抑制剂成药性研究, 参与, 研究所自主部署, 2015-09--2016-08
( 6 ) 基于新结构噻吩丙酸类GPR40完全激动剂的成药性优化及抗II型糖尿病研究, 参与, 中国科学院计划, 2016-05--2017-12
( 7 ) TD04系列化合物促小鼠胰岛新生活性评价, 负责人, 境内委托项目, 2015-12--2016-12
( 8 ) 新型DGAT1抑制剂降脂候选药物研究, 负责人, 研究所自主部署, 2016-09--2017-08
( 9 ) 抑制FABP4改善组织慢性低度炎症和糖脂代谢紊乱作用机制研究, 负责人, 研究所自主部署, 2016-09--2018-08
( 10 ) 人参皂苷Rb2调节肝细胞自噬改善非酒精性脂肪肝药理机制研究, 负责人, 研究所自主部署, 2017-05--2018-04
( 11 ) 低聚原花青素CinnamtanninD1通过促进自噬保护胰岛β细胞的药理机制研究, 负责人, 国家任务, 2018-01--2021-12
( 12 ) 基于HETEs生成抑制的胰岛β细胞保护中药活性成分和先导化合物发现研究, 负责人, 研究所自主部署, 2022-07--2024-07
( 13 ) 新型FABP4/ 5抑制剂的结构优化与抗2型糖尿病研究, 负责人, 中国科学院计划, 2019-01--2020-09
( 14 ) 新型DGAT1抑制剂降脂候选药物研究, 负责人, 国家任务, 2018-01--2020-12