基本信息
柳红  女  博导  中国科学院上海药物研究所
电子邮件: hliu@simm.ac.cn
通信地址: 上海浦东祖冲之路555号
邮政编码: 201203

招生信息

   
招生专业
100701-药物化学
招生方向
药物化学
药物设计学

教育背景

2005-01--2005-10   美国 University of Texas Medical Branch 大学   访问科学家
2002-02--2002-10   美国 University of Texas Medical Branch 大学   访问科学家
1999-09--2001-07   中国科学院上海药物研究所   博士后
1996-09--1999-07   中国药科大学   理学博士学位
1993-09--1996-07   中国药科大学   理学硕士学位
1987-09--1991-07   中国药科大学   理学学士学位

工作经历

   
工作简历
2006-07~2011-07,中国科学院上海药物研究所, 研究员,博士生导师
2005-01~2005-10,美国 University of Texas Medical Branch 大学, 访问科学家
2002-02~2002-10,美国 University of Texas Medical Branch 大学, 访问科学家
2001-09~2006-06,中国科学院上海药物研究所, 副研究员,硕士生导师
1999-09~2001-07,中国科学院上海药物研究所, 博士后
1996-09~1999-07,中国药科大学, 理学博士学位
1993-09~1996-07,中国药科大学, 理学硕士学位
1991-09~1993-08,山东新华制药厂, 助理工程师
1987-09~1991-07,中国药科大学, 理学学士学位

教授课程

药物化学

专利与奖励

   
奖励信息
(1) 第十四届中国青年科技奖, 一等奖, 部委级, 2015
(2) 上海市药学科技奖一等奖, 一等奖, 市地级, 2015
(3) 朱李月华优秀教师奖, 一等奖, 部委级, 2014
(4) 第六届全国优秀科技工作者, 一等奖, 国家级, 2014
(5) 上海市优秀学术带头人, 一等奖, 省级, 2012
(6) 第八届中国青年女科学家奖, , 国家级, 2011
(7) 中国科学院上海分院第二届“杰出, , 院级, 2010
(8) 国家基金委“杰出青年”称号, , 国家级, 2010
(9) 中国科学院“****”称号, , 院级, 2010
(10) 全国三八红旗手, , 国家级, 2009
(11) 赛诺菲安万特-中国科学院上海, , 院级, 2009
(12) 国家自然科学奖, 二等奖, 国家级, 2007
(13) 药明康德生命化学奖, 三等奖, 其他, 2007
(14) 上海市青年科技启明星跟踪, , 市地级, 2006
(15) 上海市三八红旗手, , 市地级, 2004
(16) 中国药学会施维雅青年药物化学奖, , 其他, 2004
(17) 中国化学会青年化学奖, , 其他, 2004
(18) 上海市科技进步奖, 一等奖, 市地级, 2003
(19) 上海市青年科技启明星, , 市地级, 2003
(20) 第九届科技优秀论文, 一等奖, 其他, 2003
专利成果
( 1 ) 新型咪唑并[1,2-a]吡啶类化合物、其制备方法、包含此类化合物的药物组合物及其用途, 2012, 第 1 作者, 专利号: 201210020009.X

( 2 ) :噻吩[3,2-d]并嘧啶-4-酮类化合物、其制备方法、药物组合物及用途, 2011, 第 1 作者, 专利号: 201110393905.6

( 3 ) 取代-1H-吲哚类化合物、其制备方法、其应用及其药物组合物, 2011, 第 1 作者, 专利号: ZL200610030357.X

( 4 ) 4-取代苯氨基3-硝基喹啉类化合物及其制备方法和用途, 2011, 第 2 作者, 专利号: ZL200510024351.7

( 5 ) 2, 4-二取代氨基-6-取代-[1,3,5]三嗪类化合物、其制备方法、组合物及用途, 2011, 第 5 作者, 专利号: ZL200610170024.7

( 6 ) 新型胺基吡啶类衍生物、其制备方法、生物活性及药物组合物, 2011, 第 1 作者, 专利号: 201110079133.9

( 7 ) 取代苯并氮杂环类化合物及其制备方法和用途, 2010, 第 2 作者, 专利号: 201010244757.7

( 8 ) 8-苯基黄嘌呤类化合物、其制备方法、包含该化合物的药物组合物及其用途, 2010, 第 1 作者, 专利号: 201010183800.3

( 9 ) 环庚烷并吡啶类化合物、其制备方法及药物组合物, 2007, 第 3 作者, 专利号: ZL 200710039447.X

( 10 ) 阻止阿尔茨海默氏症AB多肽纤维化的小分子抑制剂及其制备方法、药物组合物和应用, 2006, 第 3 作者, 专利号: ZL 200610028555.2

( 11 ) N,N-二取代哌嗪类衍生物及其制备方法、药物组合物和用途, 2006, 第 2 作者, 专利号: ZL 200610023677.2

( 12 ) 组合化学集中库设计与优化方法, 2004, 第 5 作者, 专利号: ZL 200410053102.6

( 13 ) SARS冠状病毒3CL蛋白酶三维结构模型与抗SARS药物, 2003, 第 5 作者, 专利号: ZL03129071.X

( 14 ) 抗SARS-coV药物作用靶标、药物筛选方法及抗SARS药物, 2003, 第 5 作者, 专利号: ZL03129067.1

( 15 ) 一类磺酰胺苯烷胺类化合物及其制备方法和用途, 2002, 第 1 作者, 专利号: ZL 02116901.2

( 16 ) 烷磺酰胺苯烷胺类化合物及其制备方法和药物用途, 2001, 第 2 作者, 专利号: ZL01132148.2

出版信息

   
发表论文
(1) Asymmetric Synthesis of Aromatic and Hetero-Aromatic α-Amino Acids Using Recyclable Axially Chiral Ligand., European Journal of Organic Chemistry., 2016, 通讯作者
(2) Recent progress in the small-molecule therapeutics for Ebola virus (EBOV) disease treatment. Synthetic profiles of three unique drugs: favipiravir, BCX-4430, and brincidofovir., European Journal of Organic Chemistry., 2016, 通讯作者
(3) Next Generation of Fluorine-containing Pharmaceuticals Compounds Currently in Phase II-III Clinical Trials of Major Pharmaceutical Companies; New Structural Trends and Therapeutic Aeas., Chemical Reviews., 2016, 通讯作者
(4) Direct access to pyrido/pyrrolo[2,1-b]quinazolin-9(1H)-ones through silver-mediated intramolecular alkyne hydroamination reactions., Beilstein Journal of Organic Chemistry., 2015, 通讯作者
(5) Asymmetric synthesis of α-(1-oxoisoindolin-3-yl)glycine: synthetic and mechanistic challenges., ChemComm., 2015, 通讯作者
(6) Design, Synthesis and Biological Evaluation of Novel Imidazo[1,2-a]pyridine Derivatives as Potent c-Met Inhibitors., ACS Medicinal Chemistry Letters., 2015, 通讯作者
(7) Recyclable Ligands for the Non-Enzymatic Dynamic Kinetic Resolution of Challenging a-Amino Acids., Angewandte Chemie International Edition., 2015, 通讯作者
(8) The facile construction of phthalazin-1(2H)-one scaffold via copper-mediated C-H(sp2)/C-H(sp) coupling under mild conditions., Beilstein Journal of Organic Chemistry., 2015, 通讯作者
(9) Palladium-Catalyzed Picolinamide-Directed Coupling of C(sp2)-H and C(sp2)-H: a Straightforward Approach to Quinolinone and Pyridone Scaffolds., ChemComm., 2015, 通讯作者
(10) Palladium-Catalyzed C2-Acylation of Indoles with α-Diketones Assisted by the Removable N-(2-Pyrimidyl) Group., European Journal of Organic Chemistry., 2015, 通讯作者
(11) Discovery and optimization of novel, selective histone methyltransferase SET7 inhibitors by pharmacophore- and docking-based virtual screening., J Med Chem., 2015, 通讯作者
(12) γ-Carbon Activation Through N-Heterocyclic Carbene/Brønsted Acids Cooperative Catalysis: A Highly Enantioselective Route to δ-Lactams., Organic Letters., 2015, 通讯作者
(13) Design, synthesis and biological evaluation of isoquinoline-based derivates as novel histone deacetylase inhibitors., Bioorganic & Medicinal Chemistry., 2015, 通讯作者
(14) Diversity-oriented synthesis and its application in drug discovery., Acta Pharmaceutica Sinica., 2015, 通讯作者
(15) Asymmetric Synthesis of (2S,3S)‑α-(1-Oxoisoindolin-3-yl)glycines under Low-Basicity “Kinetic” Control., Journal of Organic Chemistry., 2015, 通讯作者
(16) Palladium-Catalyzed Intramolecular Addition of C-N Bond to Alkynes: A Novel Approach to 3-Diketoindoles., RSC Advances., 2015, 通讯作者
(17) Chemical Dynamic Thermodynamic Resolution and S/R Interconversion of Unprotected Unnatural Tailor-made α‑Amino Acids., Journal of Organic Chemistry., 2015, 通讯作者
(18) Site-specific Indolation of Proline-based Peptides via Copper(II)-Catalyzed oxidative coupling of tertiary amine N-oxides., ChemComm., 2015, 通讯作者
(19) Fluorescent Coumarin-Artemisinin Conjugates as Mitochondria-Targeting Theranostic Probes for Enhanced Anticancer Activities., Chemistry-A European Journal., 2015, 通讯作者
(20) 通过串联反应不对称合成氧化吲哚螺环化合物的研究进展., 有机化学., 2015, 通讯作者
(21) Diastereoselective Michael Reaction of Chiral Nickel(II) Glycinate with Nitroalkenes for Asymmetric Synthesis of β-Substituted α,γ-Diaminobutyric Acid Derivatives in Water, Amino Acids, 2012, 通讯作者
(22) Discovering potent inhibitors against c-Met kinase: molecular design, organic synthesis and bioassay, Org. Biomol. Chem., 2012, 通讯作者
(23) Cell-permeable Iminocoumarine-based Fluorescent Dyes for Mitochondria, Organic Letters, 2011, 通讯作者
(24) Identification and Synthesis of N-(2-oxoindolin-3-ylidene) hydrazide derivatives against c-Met Kinase, Bioorganic and Medicinal Chemistry Letters, 2011, 通讯作者
(25) Synthesis of 2-Phenylnaphthalenes through Gold-Catalyzed Dimerization via a Highly Selective Carbon Nucleophile Pathway, Journal of Organic Chemistry, 2011, 通讯作者
(26) Synthesis of Pyrrolo[1,2-a]quinoxalines via Gold (I)-Mediated Cascade Reactions, ACS Combinatorial Science, 2011, 通讯作者
(27) Asymmetric Synthesis of Sterically and Electronically Demanding Linear ω-Trifluoromethyl Containing Amino Acids via Alkylation of Chiral Equivalents of Nucleophilic Glycine and Alanine, Journal of Organic Chemistry , 2011, 通讯作者
(28) Silver and Gold-Mediated Domino Transformation: A Strategy for Synthesizing Benzo[e]indolo[1,2-a]pyrrolo/pyrido[2,1-c] [1,4]diazepine -3,9-diones, Journal of Organic Chemistry, 2011, 通讯作者
(29) PH006, a novel and selective Src kinase inhibitor, suppresses human breast cancer growth and metastasis in vitro and in vivo, Breast Cancer Research and Treatment, 2011, 通讯作者
(30) 银催化有机合成反应的研究进展, 化学进展, 2011, 通讯作者
(31) An Effective Synthetic Entry to Fused Benzimidazoles via Iodocyclization, Advanced Synthesis Catalysis, 2011, 通讯作者
(32) Synthesis of 4-Aryl-2(5H)-furanones by Au (Ι)-Catalyzed Intramolecular Annulation, Advanced Synthesis Catalysis, 2011, 通讯作者
(33) 氟原子在药物分子设计中的应用, 有机化学, 2011, 通讯作者
(34) Identification?and?Synthesis?of?N-(2-oxoindolin-3-ylidene)?hydrazide?derivatives?against?c-Met?Kinase, Bioorganic and Medicinal Chemistry Letters, 2011, 通讯作者
(35) Design and Synthesis of First-in-Class Small Molecule RhoA Inhibitors: A New Promising Therapy for Cardiovascular Diseases, Journal of Medicinal Chemistry, 2011, 通讯作者
(36) Recent advances in the gold-catalyzed additions to C–C multiple bonds, Beilstein Journalof Organic Chemistry, 2011, 通讯作者
(37) Highly Diastereo- and Enantioselective Synthesis of syn-β-Substituted Tryptophans via the Reaction of a Chiral Equivalent of Nucleophilic Glycine and Sulfonylindoles, Chem.Comm, 2011, 通讯作者
(38) The Preparation of α-Alkyl-β-Amino Acids via β-Alanine Ni(II) Complex, Journal of Organic Chemistry, 2011, 通讯作者
(39) Enterovirus 71 and Coxsackievirus A16 3C proteases: binding to Rupintrivir and their substrate, and anti-hand, foot, and mouth disease virus drug design., Journal of Virology, 2011, 通讯作者
(40) Molecular Basis of NDM-1, a New Antibiotic Resistance Determinant, PLoS ONE, 2011, 通讯作者
(41) Apply Nickel(II) Complexes to Efficient Synthesis of α-, or β-Amino Acids, Chimia, 2011, 通讯作者
(42) Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific, PLoS Pathogens, 2011, 通讯作者
(43) Iron Deprivation Caused by a Novel Iron Chelator, Thiosemicarbazone-24, Suppresses Hepatocellular Carcinoma in vitro and in Mouse Models, Clinical Cancer Research, 2011, 通讯作者
(44) Computational Screening for Active Compounds Targeting Protein, J. Chem. Inf. Model., 2011, 通讯作者
(45)  Silver-catalyzed intramolecular hydroamination of alkynes in aqueous media: ef?cient and regioselective synthesis for fused benzimidazoles,  Green Chemistry, 2011, 通讯作者
(46) Highly α-selective synthesis of sialyl hydantoins by regiospecific domino condensationO--N acyl migration N-sialylation of carbodiimides with peracetylated sialic acid, Journal of Organic Chemistry , 2010, 通讯作者
(47) The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site, Nature Structure Molecular Biology, 2010, 通讯作者
(48) Silver and Gold-mediated Intramolecular Cyclization to Substituted Tetracyclic Isoquinolizinium Hexafluorostilbates, Journal of Organic Chemistry, 2010, 通讯作者
(49) Regioselective Synthesis of 3-Benzazepinones and Unexpected 5-Bromo-3-benzazepinones, Journal of Organic Chemistry, 2010, 通讯作者
(50) Structural Optimization and Biological Evaluation of Substituted Bisphenol A Derivatives as β-Amyloid Peptide Aggregation Inhibitors, Journal of Medicinal Chemistry, 2010, 通讯作者
(51) Gold(I)-Catalyzed Tandem Transformation: A Simple Approach for the Synthesis of Pyrrolo/Pyrido[2,1-a][1,3]benzoxazinones and Pyrrolo/Pyrido[2,1-a]quinazolinones, Journal of Organic Chemistry, 2010, 通讯作者
(52) Metal-free Synthesis of 2-Substituted (N, O, C) Benzothiazoles via an Intramolecular C–S Bond Formation,  Journal of Combinatorial Chemistry, 2010, 通讯作者
(53) A series of α-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIα catalytic activity, Journal of Medicinal Chemistry, 2010, 通讯作者
(54) Design, Synthesis and Interaction Study of Quinazoline-2(1H)-Thione Derivatives as Novel Bcl-xL Inhibitors, Journal of Medicinal Chemistry , 2010, 通讯作者
(55) Efficient Synthesis of Symmetrical α,α-Disubstituted β-Amino Acids and α,α-Disubstituted Aldehydes via Dialkylation of Nucleophilic β-Alanine Equivalen, Journal of Organic Chemistry, 2010, 通讯作者
(56) Most Efficient Routes for the Synthesis of α,β-Diamino Acid-Derived Compounds, Current Pharmaceutical Design, 2010, 通讯作者
(57) Novel Thiophene Derivatives as PTP1B Inhibitors with Selectivity and Cellular Activity,  Bioorganic Medicinal Chemistry, 2010, 通讯作者
(58) B5, a novel pyrrole-substituted indolinone, exerts potent antitumor efficacy through G2/M cell cycle arrest, Invest New Drugs, 2010, 通讯作者
(59) Ligand-free Iron/Copper Cocatalyzed N-Arylations of Aryl Halides with Amines under Microwave Irradiation, Green Chemistry, 2010, 通讯作者
(60) Gold(I)-Catalyzed One-Pot Tandem Coupling/Cyclization: An Efficient Synthesis of Pyrrolo-/Pyrido[2,1-b]benzo[d][1,3] oxazin-1-ones, Advanced Synthesis Catalysis, 2010, 通讯作者
(61) One-pot Approach for C-C Bond Formation through Ru-amino Complex Catalyzed Tandem Aldol Reaction/Hydrogenation, Synthesis, 2010, 通讯作者
(62) A Nonproton Ligand Sensor in the Acid-Sensing Ion Channel, Neuron, 2010, 通讯作者
(63) Metal-free Tandem Reaction in Water: An Efficient and Regioselective Synthesis of 3-Hydroxyisoindolin-1-ones,  Green Chemistry, 2010, 通讯作者
(64) Discovery of novel Purine derivatives with potent and selective inhibitory activity against c-Src tyrosine kinase, Bioorganic Medicinal Chemistry, 2010, 通讯作者
(65) Gold(I)-Catalyzed Cascade for Synthesis of Pyrrolo[1,2-a:2,1-c] Pyrido[2,1-c]pyrrolo[1,2-a]quinoxalinones, Advanced Synthesis Catalysis, 2010, 通讯作者
发表著作
( 1 ) 药物基因组学-寻求个性化治疗, Pharmacogenomics - The Search for Individualized Therapies, 科学出版社, 2005-07, 第 4 作者
( 2 ) 基于活性化合物和分子靶标的集中组合库设计:药物发现的方法和应用, Focused Library Design Based on Hit and Target Structures:Method and Application in Drug Discovery, John Wiley Sons, 2007-07, 第 4 作者
( 3 ) 新分子实体的发现与优化策略, The discovery and optimization strategies of new molecular entities , 北京化学工业出版社, 2009-07, 第 1 作者
( 4 ) 高等药物化学, Advanced Medicinal Chemistry, 科学出版社, 2011-07, 第 4 作者
( 5 ) 高等药物化学, Advanced Medicinal Chemistry, 科学出版社, 2011-07, 第 1 作者
( 6 ) 微波在有机合成和药物研发中的作用, Microwave Heating in Organic Synthesis and Drug Discovery, InTech, 2011-07, 第 1 作者

科研活动

   
科研项目
( 1 ) 新型钾离子通道阻滞剂的发现及其亚型的选择性和功能研究, 负责人, 国家任务, 2008-01--2011-12
( 2 ) 抗糖尿病类LJN系列新药候选物的临床前研究, 负责人, 国家任务, 2012-01--2015-12
( 3 ) 基于蛋白质调控网络的系统生物学研究, 负责人, 国家任务, 2015-01--2019-12
( 4 ) S1P在肿瘤细胞糖脂代谢异常及非可控性炎症向肿瘤癌转化中的分子调控, 负责人, 国家任务, 2013-01--2016-12
( 5 ) 疾病网络动力学干预与药物设计, 负责人, 国家任务, 2015-01--2019-12
( 6 ) 含氮多环类药性化合物库的构建与创新药物发现及可视化研究, 负责人, 国家任务, 2017-01--2019-12
( 7 ) 金属螯合物不对称合成非天然氨基酸及其在创新药物发现与合成中的研究, 负责人, 国家任务, 2017-01--2019-12