基本信息
柳红  女  博导  中国科学院上海药物研究所
电子邮件: hliu@simm.ac.cn
通信地址: 上海浦东祖冲之路555号
邮政编码: 201203

招生信息

   
招生专业
100701-药物化学
招生方向
药物化学
药物设计学

教育背景

2005-01--2005-10   美国 University of Texas Medical Branch 大学   访问科学家
2002-02--2002-10   美国 University of Texas Medical Branch 大学   访问科学家
1999-09--2001-07   中国科学院上海药物研究所   博士后
1996-09--1999-07   中国药科大学   理学博士学位
1993-09--1996-07   中国药科大学   理学硕士学位
1987-09--1991-07   中国药科大学   理学学士学位

工作经历

   
工作简历
2006-07~现在, 中国科学院上海药物研究所, 研究员,博士生导师
2005-01~2005-10,美国 University of Texas Medical Branch 大学, 访问科学家
2002-02~2002-10,美国 University of Texas Medical Branch 大学, 访问科学家
2001-09~2006-06,中国科学院上海药物研究所, 副研究员,硕士生导师
1999-09~2001-07,中国科学院上海药物研究所, 博士后
1996-09~1999-07,中国药科大学, 理学博士学位
1993-09~1996-07,中国药科大学, 理学硕士学位
1991-09~1993-08,山东新华制药厂, 助理工程师
1987-09~1991-07,中国药科大学, 理学学士学位

教授课程

药物化学

专利与奖励

   
奖励信息
(1) 中国科学院“朱李月华优秀教师”奖, 院级, 2022
(2) 上海市巾帼创新领军人才, 省级, 2022
(3) 第三十三届上海市优秀发明选拔赛优秀发明银奖, 省级, 2021
(4) 上海市最美科技工作者, 省级, 2021
(5) 第十六届中国药学会科学技术奖, 一等奖, 省级, 2021
(6) “中国民主同盟抗击新冠肺炎疫情先进个人”称号, 其他, 2020
(7) 2019年度上海药学科技奖, 一等奖, 省级, 2020
(8) 第二十一届中国专利优秀奖, 部委级, 2020
(9) 第二十一届吴阶平-保罗·杨森医学药学奖, 省级, 2020
(10) 上海市科学技术奖科技进步一等奖, 一等奖, 省级, 2020
(11) 第十四届中国青年科技奖, 一等奖, 部委级, 2015
(12) 上海市药学科技奖一等奖, 一等奖, 市地级, 2015
(13) 朱李月华优秀教师奖, 一等奖, 部委级, 2014
(14) 第六届全国优秀科技工作者, 一等奖, 国家级, 2014
(15) 上海市优秀学术带头人, 一等奖, 省级, 2012
(16) 第八届中国青年女科学家奖, , 国家级, 2011
(17) 中国科学院上海分院第二届“杰出, , 院级, 2010
(18) 国家基金委“杰出青年”称号, , 国家级, 2010
(19) 中国科学院“****”称号, , 院级, 2010
(20) 赛诺菲安万特-中国科学院上海, , 院级, 2009
(21) 全国三八红旗手, , 国家级, 2009
(22) 国家自然科学奖, 二等奖, 国家级, 2007
(23) 药明康德生命化学奖, 三等奖, 其他, 2007
(24) 上海市青年科技启明星跟踪, , 市地级, 2006
(25) 上海市三八红旗手, , 市地级, 2004
(26) 中国药学会施维雅青年药物化学奖, , 其他, 2004
(27) 中国化学会青年化学奖, , 其他, 2004
(28) 第九届科技优秀论文, 一等奖, 其他, 2003
(29) 上海市青年科技启明星, , 市地级, 2003
(30) 上海市科技进步奖, 一等奖, 市地级, 2003
专利成果
( 1 ) 基于苯乙烯噁唑酮类化合物的荧光探针及其生物应用, 2022, 第 1 作者, 专利号: CN114058369A

( 2 ) 一类五环三萜类碳苷化合物及其制备方法和用途, 2022, 第 1 作者, 专利号: CN113896757A

( 3 ) 一类噁二唑类化合物及其制备方法、药物组合物和用途, 2021, 第 1 作者, 专利号: CN113861178A

( 4 ) 醛基类化合物及其制备方法、药物组合物和用途, 2021, 第 1 作者, 专利号: CN113620929A

( 5 ) 黄芩主要成分黄芩素、黄芩苷及其组合物在抗冠状病毒中的应用, 2021, 第 5 作者, 专利号: CN113244211A

( 6 ) 黄芩、连翘、金银花主要成分及其组合物在抗冠状病毒中的应用, 2021, 第 9 作者, 专利号: CN113209164A

( 7 ) 一种酮酰胺类化合物的药物用途, 2021, 第 1 作者, 专利号: CN113197895A

( 8 ) 一种醛基类化合物的药物用途, 2021, 第 1 作者, 专利号: CN113181339A

( 9 ) 酮酰胺类化合物及其制备方法、药物组合物和用途, 2021, 第 1 作者, 专利号: CN113015726A

( 10 ) 一种乙酰胆碱酯酶抑制剂的晶型及其制备方法和应用, 2021, 第 1 作者, 专利号: CN112939846A

( 11 ) 苯甲酰胺类化合物及其制备方法、药物组合物和用途, 2021, 第 2 作者, 专利号: CN112812077A

( 12 ) 一类并环吡唑啉酮甲酰胺类化合物及其制备方法、药物组合物和用途, 2021, 第 1 作者, 专利号: CN112236430A

( 13 ) 一类丙烯酸类化合物及其制备方法、药物组合物和用途, 2021, 第 1 作者, 专利号: CN112204018A

( 14 ) 联芳基类化合物、其制备方法、药物组合物及其应用, 2020, 第 1 作者, 专利号: CN110950807A

( 15 ) 芬戈莫德或其盐在治疗囊肿性疾病中的用途, 2020, 第 3 作者, 专利号: CN105560219B

( 16 ) 一种苯基吡唑类化合物、药物组合物、其制备方法及应用, 2020, 第 2 作者, 专利号: CN110746355A

( 17 ) 一类并环吡唑啉酮甲酰胺类化合物及其制备方法、药物组合物和用途, 2019, 第 1 作者, 专利号: CN110511218A

( 18 ) 一类丙烯酸类化合物及其制备方法、药物组合物和用途, 2019, 第 1 作者, 专利号: CN110483432A

( 19 ) 一类含氟异噁唑类化合物及其制备方法、药物组合物和用途, 2019, 第 1 作者, 专利号: CN110452235A

( 20 ) 一种噻吩3,2-d并嘧啶-4-酮类化合物的药物新用途, 2019, 第 1 作者, 专利号: CN110240603A

( 21 ) 四氢异喹啉类化合物、其制备方法、包含此类化合物的药物组合物及其用途, 2019, 第 2 作者, 专利号: CN110117271A

( 22 ) 四氢异喹啉类化合物、其制备方法、包含此类化合物的药物组合物及其用途, 2019, 第 2 作者, 专利号: CN110117271A

( 23 ) 新型手性配体、金属螯合物、多种非天然氨基酸、马拉维诺及其关键中间体的合成方法, 2019, 第 1 作者, 专利号: CN109790114A

( 24 ) 五元杂环并3,4-d哒嗪酮类化合物、其制备方法、药物组合物及其应用, 2019, 第 2 作者, 专利号: CN109641908A

( 25 ) 一类氟取代的环丙胺类化合物及其制备方法、药物组合物和用途, 2018, 第 1 作者, 专利号: CN108779096A

( 26 ) 1,3-二氧六环-4,6-二酮类化合物、其制备方法、药物组合物及其应用, 2018, 第 2 作者, 专利号: CN108640898A

( 27 ) 1,3-二氧六环-4,6-二酮类化合物、其制备方法、药物组合物及其应用, 2018, 第 2 作者, 专利号: CN108640898A

( 28 ) 新型手性配体、金属螯合物、多种非天然氨基酸、马拉维诺及其关键中间体的合成方法, 2018, 第 1 作者, 专利号: CN107879963A

( 29 ) 一种C,O‑螺环芳基糖苷类化合物及其制备和应用, 2018, 第 1 作者, 专利号: CN107709332A

( 30 ) 5‑芳香炔基取代的苯甲酰胺类化合物及其制备方法、药物组合物和用途, 2018, 第 1 作者, 专利号: CN107531633A

( 31 ) 反吲哚啉环丙胺类化合物及其制备方法、药物组合物和用途, 2017, 第 1 作者, 专利号: CN107459476A

( 32 ) 五元杂环并3,4‑d哒嗪酮类化合物、其制备方法、药物组合物及其应用, 2017, 第 2 作者, 专利号: CN107417687A

( 33 ) 一类含氟三氮唑并吡啶类化合物及其制备方法、药物组合物和用途, 2017, 第 1 作者, 专利号: CN107383002A

( 34 ) 一种苯g杂芳基并a,g喹嗪类化合物的药物用途及其制备方法, 2017, 第 1 作者, 专利号: CN107303298A

( 35 ) 苯基a吲哚2,3-g并喹嗪类化合物、其制备方法、药物组合物及其应用, 2017, 第 1 作者, 专利号: CN107286158A

( 36 ) 一种DPPIV抑制剂的盐型及其制备方法, 2017, 第 1 作者, 专利号: CN107216340A

( 37 ) 一种DPPIV抑制剂马来酸盐的多晶型及其制备方法, 2017, 第 1 作者, 专利号: CN107216339A

( 38 ) 一类氟取代的环丙胺类化合物及其制备方法、药物组合物和用途, 2017, 第 1 作者, 专利号: CN107200706A

( 39 ) 醛基类化合物及其制法和用途, 2017, 第 1 作者, 专利号: CN106928206A

( 40 ) 一种C,O-螺环芳基糖苷类化合物及其制备和应用, 2017, 第 1 作者, 专利号: CN106317068A

( 41 ) 苯并吡唑联吡啶类化合物、包含此类化合物的药物组合物及其用途, 2017, 第 1 作者, 专利号: CN106279101A

( 42 ) 3,4,5-三取代吡唑类化合物、制备方法、药物组合物及用途, 2017, 第 1 作者, 专利号: CN106279023A

( 43 ) 5-芳香炔基取代的苯甲酰胺类化合物及其制备方法、药物组合物和用途, 2016, 第 1 作者, 专利号: CN106146391A

( 44 ) 一种化合物的A晶型及其制备方法, 2016, 第 1 作者, 专利号: CN105985353A

( 45 ) 一种1-(3-氨基丙基)取代环状胺类化合物、其制备方法、药物组合物及用途, 2016, 第 1 作者, 专利号: CN105873924A

( 46 ) 用于抑制人铜转运蛋白ATOX1和CCS的方法和组合物, 2015, 第 5 作者, 专利号: CN105189474A

( 47 ) 氨基醇类化合物、其制备方法、包含此类化合物的药物组合物及其用途, 2015, 第 3 作者, 专利号: CN105017034A

( 48 ) 一种1-(3-氨基丙基)取代环状胺类化合物、其制备方法、药物组合物及用途, 2015, 第 1 作者, 专利号: CN104744451A

( 49 ) 一类二氢吲哚类化合物、其制备方法、药物组合物及应用, 2015, 第 1 作者, 专利号: CN104326963A

( 50 ) 一类吲哚类化合物、其制备方法、药物组合物及应用, 2014, 第 1 作者, 专利号: CN104211631A

( 51 ) 一种六氢二苯并a,g喹嗪类化合物的药物用途, 2014, 第 1 作者, 专利号: CN104127414A

( 52 ) 一类氟取代的环状胺类化合物及其制备方法、药物组合物和用途, 2014, 第 1 作者, 专利号: CN103787954A

( 53 ) 1,3-取代脲或硫脲化合物、其制备方法、药物组合物和应用, 2014, 第 5 作者, 专利号: CN103709097A

( 54 ) 芳基a吲哚2,3-g并喹嗪类化合物、其制备方法、药物组合物及其应用, 2014, 第 1 作者, 专利号: CN103664974A

( 55 ) 新型青蒿素衍生物及其制法和应用, 2014, 第 2 作者, 专利号: CN103570738A

( 56 ) 2-取代-5-苯基呋喃类化合物、其制备方法、药物组合物及其用途, 2014, 第 2 作者, 专利号: CN103509009A

( 57 ) 二芳基并a,g喹嗪类化合物、其制备方法、药物组合物及其应用, 2013, 第 1 作者, 专利号: CN103387583A

( 58 ) 新型咪唑并1,2-a吡啶类化合物、其制备方法、包含此类化合物的药物组合物及其用途, 2013, 第 1 作者, 专利号: CN103214481A

( 59 ) 噻吩3,2-d并嘧啶-4-酮类化合物、其制备方法、药物组合物及用途, 2013, 第 1 作者, 专利号: CN103130819A

( 60 ) 六氢二苯并a,g喹嗪类化合物、其制备方法、药物组合物及其应用, 2012, 第 1 作者, 专利号: CN102796096A

( 61 ) 新型胺基吡啶类化合物、其制备方法、包含此类化合物的药物组合物及其用途, 2012, 第 1 作者, 专利号: CN102718745A

( 62 ) 2-((2-(3-氨基哌啶-1)-4-氧噻吩3,2-d嘧啶-3(4H)-甲基)苯甲腈多晶型体、其制备方法及其药理用途, 2012, 第 1 作者, 专利号: CN102659813A

( 63 ) 新型唾液酸衍生物及其制备方法,包含该衍生物的药物组合物,以及其用途, 2012, 第 1 作者, 专利号: CN102532080A

( 64 ) 8-苯基黄嘌呤类化合物、其制备方法、包含该化合物的药物组合物及其用途, 2011, 第 1 作者, 专利号: CN102260260A

( 65 ) 喹唑啉-2(1H)吡啶硫酮类衍生物、其药物组合物、制备方法及应用, 2011, 第 2 作者, 专利号: CN102190668A

( 66 ) 环庚烷并吡啶类化合物、其制备方法、用途及包含此类化合物的药物组合物, 2011, 第 3 作者, 专利号: CN101284828B

( 67 ) 取代苯并氮杂环类衍生物的制备及其药理用途, 2010, 第 2 作者, 专利号: CN101921238A

( 68 ) 取代磺酰胺类化合物及其制备方法、药物组合物和应用, 2010, 第 3 作者, 专利号: CN101817767A

( 69 ) 一类5-脂氧酶抑制剂及其制备方法、药物组合物和应用, 2010, 第 1 作者, 专利号: CN101684098A

( 70 ) 新颖的吡唑类5-脂氧酶小分子抑制剂及其制备方法、药物组合物和应用, 2009, 第 1 作者, 专利号: CN101544631A

( 71 ) 取代黄酮类化合物、其制备方法、其应用及其药物组合物, 2008, 第 1 作者, 专利号: CN101265250A

( 72 ) 四氢喹啉类化合物、其制备方法及药物组合物, 2008, 第 3 作者, 专利号: CN101245062A

( 73 ) 2,4-二取代氨基-6-取代-1,3,5三嗪或1,3-嘧啶类化合物、其制备方法、药物组合物及用途, 2008, 第 5 作者, 专利号: CN101245051A

( 74 ) 1-取代-4,4-二取代氨基硫脲类化合物、其制备方法以及其用途, 2008, 第 1 作者, 专利号: CN101195597A

( 75 ) 取代-1H-吲哚类化合物、其制备方法、其应用及其药物组合物, 2008, 第 1 作者, 专利号: CN101130515A

( 76 ) 一种选择性催化两步合成手性2-氨基-3,3-二芳基丙酸类化合物的新方法, 2008, 第 1 作者, 专利号: CN101108810A

( 77 ) 阻止阿尔茨海默氏症Aβ多肽纤维化的小分子抑制剂及其制备方法、药物组合物和应用, 2008, 第 3 作者, 专利号: CN101100416A

( 78 ) N,N'-二取代哌嗪类衍生物及其制备方法、药物组合物和用途, 2007, 第 2 作者, 专利号: CN101007794A

( 79 ) 3-烷氧取代-2,5,7-三取代苯并吡喃-4-酮类化合物及其制备方法和包含该类化合物的药物组合物, 2007, 第 8 作者, 专利号: CN1990479A

( 80 ) 取代1,3,5三嗪类化合物及其制备方法和应用, 2007, 第 1 作者, 专利号: CN1970552A

( 81 ) 二氢喹啉类化合物、其制备方法及药物组合物, 2007, 第 5 作者, 专利号: CN1958572A

( 82 ) 一类羧酸衍生物,其制备方法及药物组合物, 2006, 第 5 作者, 专利号: CN1861560A

( 83 ) 4-取代苯氨基-3-硝基喹啉类化合物及其制备方法和用途, 2006, 第 2 作者, 专利号: CN1830964A

( 84 ) 五羟黄酮-3-β-半乳糖苷的医药用途及其制剂, 2006, 第 9 作者, 专利号: CN1830449A

( 85 ) 2-取代酰氨基二羧酸类化合物、其制备方法及用途, 2006, 第 6 作者, 专利号: CN1789240A

( 86 ) 取代 1H-吲哚-2-酮类化合物及其制备方法和用途, 2006, 第 7 作者, 专利号: CN1769284A

( 87 ) 组合化学集中库设计与优化方法, 2006, 第 7 作者, 专利号: CN1725222A

( 88 ) SARS冠状病毒3CL蛋白酶三维结构模型与抗SARS药物, 2006, 第 16 作者, 专利号: CN1237185C

( 89 ) 抗SARS-CoV药物作用靶标、药物筛选方法及抗SARS药物, 2006, 第 11 作者, 专利号: CN1237184C

( 90 ) 一类2,3,5-三取代-4-噻唑烷酮化合物及其药理用途, 2005, 第 11 作者, 专利号: CN1699354A

( 91 ) 一类2,3,5-三取代-4-噻唑烷酮化合物及其药理用途, 2005, 第 11 作者, 专利号: CN1699355A

( 92 ) SARS冠状病毒3CL蛋白酶活性测定和抑制剂筛选方法, 2005, 第 7 作者, 专利号: CN1690691A

( 93 ) 1,4-二取代苯类化合物及其制备方法和用途, 2005, 第 4 作者, 专利号: CN1660811A

( 94 ) 2-取代亚胺噻唑烷衍生物,其制备工艺及药物组合物, 2005, 第 5 作者, 专利号: CN1657529A

( 95 ) 哌嗪三嗪类化合物、其制备方法及药物组合物, 2005, 第 2 作者, 专利号: CN1629157A

( 96 ) 紫锥松果菊提取物的抗SARS作用及其药物组合物, 2004, 第 1 作者, 专利号: CN1476836

( 97 ) 烷磺酰胺苯烷胺类化合物及其制备方法与药物用途, 2003, 第 2 作者, 专利号: CN1417206A

( 98 ) 一类磺酰胺苯烷胺类化合物及其制备方法和用途, 2003, 第 1 作者, 专利号: CN1400207A

出版信息

   
发表论文
(1) Synthesis of maleimide-braced peptide macrocycles and their potential anti-SARS-CoV-2 mechanisms, CHEMICAL COMMUNICATIONS, 2023, 通讯作者
(2) Controlled sequential in situ self-assembly and disassembly of a fluorogenic cisplatin prodrug for cancer theranostics, NATURE COMMUNICATIONS, 2023, 通讯作者
(3) Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4), NATURE COMMUNICATIONS, 2023, 通讯作者
(4) Structural Optimization of Fibroblast Growth Factor Receptor Inhibitors for Treating Solid Tumors, JOURNAL OF MEDICINAL CHEMISTRY, 2023, 通讯作者
(5) Discovery, synthesis and mechanism study of 2,3,5-substituted 1,2,4-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 通讯作者
(6) Construction of Vinyl-Substituted N-Heterocycles via Rh(III)- Catalyzed C-H Functionalization/Annulation of Pyrazolidinones, ADVANCED SYNTHESIS & CATALYSIS, 2023, 通讯作者
(7) Smart Nanosensitizers for Activatable Sono-Photodynamic Immunotherapy of Tumors by Redox-Controlled Disassembly, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2023, 通讯作者
(8) Cobalt(II)-Catalyzed C(sp3)-C(sp3) Coupling for the Direct Stereoselective Synthesis of 2-Deoxy-C-glycosides from Glycals., Angewandte Chemie International Edition, 2023, 通讯作者
(9) Engineering of donor-acceptor-donor curcumin analogues as near-infrared fluorescent probes for in vivo imaging of amyloid-β species, THERANOSTICS, 2022, 通讯作者
(10) Controlling Disassembly of Paramagnetic Prodrug and Photosensitizer Nanoassemblies for On-Demand Orthotopic Glioma Theranostics, ACS NANO, 2022, 通讯作者
(11) 盘状结构域受体1(DDR1)激酶抑制剂的研究进展, Research Progress of Discoid Domain Receptor 1(DDR1) Inhibitors, 有机化学, 2022, 通讯作者
(12) Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial, CELL METABOLISM, 2022, 通讯作者
(13) Inhibition of the dopamine transporter promotes lysosome biogenesis and ameliorates Alzheimer's disease-like symptoms in mice, ALZHEIMERS & DEMENTIA, 2022, 通讯作者
(14) A Facile Electrochemical Strategy for the Azidation of Benzylic C(sp(3))-H Bonds, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2022, 通讯作者
(15) Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2, JOURNAL OF MEDICINAL CHEMISTRY, 2022, 通讯作者
(16) Discovery of Novel Imidazo4,5-cquinoline Derivatives to Treat Inflammatory Bowel Disease (IBD) by Inhibiting Multiple Proinflammatory Signaling Pathways and Restoring Intestinal Homeostasis, JOURNAL OF MEDICINAL CHEMISTRY, 2022, 通讯作者
(17) Structure-Based Design of Tropane Derivatives as a Novel Series of CCR5 Antagonists with Broad-Spectrum Anti-HIV-1 Activities and Improved Oral Bioavailability, JOURNAL OF MEDICINAL CHEMISTRY, 2022, 通讯作者
(18) Rh(III)-Catalyzed C-H Activation and 4+1+1 Sequential Cyclization Cascade to Give Highly Fused Indano1,2-bazirines, ORGANIC LETTERS, 2022, 第 7 作者
(19) A Novel SphK1 Inhibitor Suppresses Growth of Solid Tumor and Inhibits the Lung Metastasis of Triple-negative Breast Cancer., JOURNAL OF MEDICINAL CHEMISTRY, 2022, 通讯作者
(20) In vitro and in vivo evaluation of the main protease inhibitor FB2001 against SARS-CoV-2, ANTIVIRAL RESEARCH, 2022, 通讯作者
(21) Discovery of Novel Pyrrolo2,3-dpyrimidine-based Derivatives as Potent JAK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors, JOURNAL OF MEDICINAL CHEMISTRY, 2022, 通讯作者
(22) Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors, JOURNAL OF MEDICINAL CHEMISTRY, 2022, 通讯作者
(23) Bioinspired large Stokes shift small molecular dyes for biomedical fluorescence imaging, SCIENCE ADVANCES, 2022, 通讯作者
(24) Cu(II) Complexes with Proline-Derived Schiff Base Ligand: Chemical Resolution of N,C-Unprotected ?-Amino Acids and Their Antibacterial Activity, JOURNAL OF ORGANIC CHEMISTRY, 2022, 通讯作者
(25) Discovery of Pyrazolo3,4-dpyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation, JOURNAL OF MEDICINAL CHEMISTRY, 2022, 通讯作者
(26) A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB/CRTC2 transcriptional complex, NATURE COMMUNICATIONS, 2022, 通讯作者
(27) 5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 第 17 作者
(28) Identification of Novel Fused Heteroaromatics-Based MALT1 Inhibitors by High-Throughput Screening to Treat B Cell Lymphoma, JOURNAL OF MEDICINAL CHEMISTRY, 2021, 通讯作者
(29) A metal-free method for the facile synthesis of indanones via the intramotecular hydroacylation of 2-vinytbenzaldehyde, GREEN CHEMISTRY, 2021, 通讯作者
(30) Sulfoximines Assisted Rh(III)-Catalyzed C-H Activation/Annulation Cascade to Synthesize Highly Fused Indeno-1,2-benzothiazines, JOURNAL OF ORGANIC CHEMISTRY, 2021, 通讯作者
(31) A Rh(iii)-catalyzed C-H activation/regiospecific annulation cascade of benzoic acids with propargyl acetates to unusual 3-alkylidene-isochromanones, ORGANIC CHEMISTRY FRONTIERS, 2021, 通讯作者
(32) Synthesis of Pyrazolo1,2-acinnolines via Rhodium(III)-Catalyzed 4+2 Annulation Reactions of Pyrazolidinones with Sulfoxonium Ylides, ADVANCED SYNTHESIS & CATALYSIS, 2021, 通讯作者
(33) Structures of human mGlu2 and mGlu7 homo- and heterodimers, NATURE, 2021, 通讯作者
(34) Discovery of novel ceramide analogs with favorable pharmacokinetic properties and combination with AKT inhibitor against colon cancer, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 第 9 作者
(35) Catalytic System-Controlled Divergent Reaction Strategies for the Construction of Diversified Spiropyrazolone Skeletons from Pyrazolidinones and Diazopyrazolones, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 通讯作者
(36) Design, synthesis and biological evaluation of pyrazolo3,4-dpyridazinone derivatives as covalent FGFR inhibitors, Design, synthesis and biological evaluation of pyrazolo3,4-dpyridazinone derivatives as covalent FGFR inhibitors, ACTA PHARMACEUTICA SINICA B, 2021, 通讯作者
(37) Direct C4-Acetoxylation of Tryptophan and Tryptophan-Containing Peptides via Palladium(II)-Catalyzed C-H Activation, ORGANIC LETTERS, 2021, 第 7 作者
(38) Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 通讯作者
(39) I-2-induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines, GREEN CHEMISTRY, 2021, 通讯作者
(40) Ir(I)-Catalyzed C-H Glycosylation for Synthesis of 2-Indolyl-C-Deoxyglycosides, ADVANCED SYNTHESIS & CATALYSIS, 2021, 通讯作者
(41) 抗新冠肺炎药物研究进展, Recent Progress in Drug Development against COVID-19, 中国生物工程杂志, 2021, 第 2 作者
(42) Rhodium-Catalyzed C-H Activation/Annulation Cascade of Aryl Oximes and Propargyl Alcohols to Isoquinoline N-Oxides, ADVANCED SYNTHESIS & CATALYSIS, 2021, 通讯作者
(43) Discovery of 5-Benzylidene-2-phenyl-1,3-dioxane-4,6-diones as Highly Potent and Selective SIRT1 Inhibitors, ACS MEDICINAL CHEMISTRY LETTERS, 2021, 通讯作者
(44) MALT1 as a promising target to treat lymphoma and other diseases related to MALT1 anomalies, MEDICINAL RESEARCH REVIEWS, 2021, 通讯作者
(45) Structural optimization and biological evaluation for novel artemisinin derivatives against liver and ovarian cancers, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 通讯作者
(46) Rh(III)-Catalyzed 5+1 Annulation of Indole-enaminones with Diazo Compounds To Form Highly Functionalized Carbazoles, ORGANIC LETTERS, 2021, 通讯作者
(47) Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate, JOURNAL OF MEDICINAL CHEMISTRY, 2021, 通讯作者
(48) Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia, JOURNAL OF MEDICINAL CHEMISTRY, 2021, 通讯作者
(49) Deep Learning Enhancing Kinome-Wide Polypharmacology Profiling: Model Construction and Experiment Validation, JOURNAL OF MEDICINAL CHEMISTRY, 2020, 第 16 作者
(50) Palladium-catalyzed 4+3 dearomatizing cycloaddition reaction of N-iminoquinolinium ylides, ORGANIC CHEMISTRY FRONTIERS, 2020, 通讯作者
(51) Sulfoximines-Assisted Rh(III)-Catalyzed C–H Activation and Intramolecular Annulation for the Synthesis of Fused Isochromeno-1,2-Benzothiazines Scaffolds under Room Temperature, MOLECULES, 2020, 通讯作者
(52) Design, Synthesis, and Biological Evaluation of 8-Mercapto-3,7-Dihydro-1 H -Purine-2,6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5, MOLECULES, 2020, 通讯作者
(53) Ruthenium-Catalyzed C-H Activations for the Synthesis of Indole Derivatives, CATALYSTS, 2020, 通讯作者
(54) Rhodium(III)-Catalyzed Redox-Neutral 3+3 Annulation of N -nitrosoanilines with Cyclopropenones: A Traceless Approach to Quinolin-4(1 H )-One Scaffolds, MOLECULES, 2020, 通讯作者
(55) Pd(II)-Catalyzed Direct gamma-C(sp(3))-H Arylation between Free beta(2)-Amino Esters and beta(3)-Amino Esters and Aryl Iodides Using a Catalytic Transient Directing Group, JOURNAL OF ORGANIC CHEMISTRY, 2020, 通讯作者
(56) DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PKA-CREB signaling, BIOCHEMICAL PHARMACOLOGY, 2020, 第11作者
(57) A removable directing group-assisted Rh(iii)-catalyzed direct C-H bond activation/annulation cascade to synthesize highly fused isoquinolines, ORGANIC CHEMISTRY FRONTIERS, 2020, 通讯作者
(58) Palladium-Catalysed C(sp(3))-H Glycosylation for the Synthesis of C-Alkyl Glycoamino Acids, ANGEWANDTECHEMIEINTERNATIONALEDITION, 2020, 通讯作者
(59) Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients, Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients, ACTA PHARMACOLOGICA SINICA, 2020, 其他(合作组作者)
(60) Ru(ii)-catalyzed C6-selective C-H acylmethylation of pyridones using sulfoxonium ylides as carbene precursors, RSC ADVANCES, 2020, 第 5 作者
(61) 先导化合物结构优化策略(八)——药物转运体及其相关药物设计策略, Lead compound optimization strategy(8)-drug transporters and related drug design strategies, 药学学报, 2020, 通讯作者
(62) 先导化合物结构优化策略七肽类分子结构修饰与改造, 药学学报, 2020, 通讯作者
(63) Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4, NATURE, 2020, 第 15 作者
(64) Discovery and Optimization of Non-bile Acid FXR Agonists as Preclinical Candidates for the Treatment of Nonalcoholic Steatohepatitis, JOURNAL OF MEDICINAL CHEMISTRY, 2020, 其他(合作组作者)
(65) Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease, SCIENCE, 2020, 通讯作者
(66) Synthesis of Highly Fused Pyrano2,3-bpyridines via Rh(III)- Catalyzed C-H Activation and Intramolecular Cascade Annulation under Room Temperature, JOURNAL OF ORGANIC CHEMISTRY, 2020, 通讯作者
(67) Structure of M-pro from SARS-CoV-2 and discovery of its inhibitors, NATURE, 2020, 第 22 作者
(68) Rhodium(III)-Catalyzed C-H Alkenylation: Access to Maleimide-Decorated Tryptophan and Tryptophan-Containing Peptides, ORGANIC LETTERS, 2020, 通讯作者
(69) Design, synthesis, and biological evaluation of 1,2,5-oxadiazole-3-carboximidamide derivatives as novel indoleamine-2,3-dioxygenase 1 inhibitors., EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 通讯作者
(70) alpha-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment, JOURNAL OF MEDICINAL CHEMISTRY, 2020, 通讯作者
(71) Ir(iii)-Catalyzed direct C-H functionalization of N-phenylacetamide with alpha-diazo quinones: a novel strategy for producing 2-hydroxy-2 '-amino-1,2 '-biaryl scaffolds, CHEMICAL COMMUNICATIONS, 2020, 通讯作者
(72) 铑催化碳氢二氟烯丙基化/N-碘代丁二酰亚胺介导的环化反应构建含氟3,4-二氢嘧啶并1,6-a吲哚-1(2H)-酮衍生物, Cp*Rh(Ⅲ)-Catalyzed C—H 3,3-Difluoroallylation of Indoles and N-Iodosuccinimide-Mediated Cyclization for the Synthesis of Fluorinated 3,4-Dihydropyrimido-1,6-a-indol-1(2H)-one Derivatives, 有机化学, 2020, 通讯作者
(73) Optimizing chemical reaction conditions using deep learning: a case study for the Suzuki-Miyaura cross-coupling reaction, ORGANIC CHEMISTRY FRONTIERS, 2020, 第 14 作者
(74) Rh(III)-Catalyzed Dual C-H Functionalization/Cyclization Cascade by a Removable Directing Group: A Method for Synthesis of Polycyclic Fused PyranodeIsochromenes, JOURNAL OF ORGANIC CHEMISTRY, 2020, 第 5 作者
(75) Supramolecular Drug-Drug Complex Vesicles Enable Sequential Drug Release for Enhanced Combination Therapy, ACS APPLIED MATERIALS & INTERFACES, 2020, 通讯作者
(76) Ruthenium(ii)-catalyzed selective C-H bond activation of imidamides and coupling with sulfoxonium ylides: an efficient approach for the synthesis of highly functional 3-ketoindoles, ORGANIC CHEMISTRY FRONTIERS, 2019, 通讯作者
(77) Design, synthesis and biological evaluation of 6-deoxy O-spiroketal C-arylglucosides as novel renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 通讯作者
(78) Discovery and Development of a Series of Pyrazolo3,4-dpyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design, JOURNAL OF MEDICINAL CHEMISTRY, 2019, 通讯作者
(79) Rh(III)-Catalyzed C-H Bond Activation for the Construction of Heterocycles with sp(3)-Carbon Centers, CATALYSTS, 2019, 第 3 作者
(80) Rh(III)-Catalyzed Annulation of Boc-Protected Benzamides with Diazo Compounds: Approach to Isocoumarins, MOLECULES, 2019, 通讯作者
(81) One-Pot NBS-Promoted Synthesis of Imidazoles and Thiazoles from Ethylarenes in Water, MOLECULES, 2019, 通讯作者
(82) Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent, JOURNAL OF MEDICINAL CHEMISTRY, 2019, 通讯作者
(83) Ni(ii)-catalyzed mono-selective ortho-arylation of unactivated aryl C-H bonds utilizing amino acids as a directing group, RSC ADVANCES, 2019, 通讯作者
(84) A11, a novel diaryl acylhydrazone derivative, exerts neuroprotection against ischemic injury in vitro and in vivo, a11anoveldiarylacylhydrazonederivativeexertsneuroprotectionagainstischemicinjuryinvitroandinvivo, ACTA PHARMACOLOGICA SINICA, 2019, 通讯作者
(85) Green and Facile Assembly of Diverse Fused N -Heterocycles Using Gold-Catalyzed Cascade Reactions in Water, MOLECULES, 2019, 通讯作者
(86) Recent Advances in the Addition of Amide/Sulfonamide Bonds to Alkynes, MOLECULES, 2019, 通讯作者
(87) Molecular binding mode of PF-232798, a clinical anti-HIV candidate, at chemokine receptor CCR5, molecularbindingmodeofpf232798aclinicalantihivcandidateatchemokinereceptorccr5, ACTA PHARMACOLOGICA SINICA, 2019, 第 4 作者
(88) Gold-catalyzed Rapid Construction of Nitrogen-containing Heterocyclic Compound Library with Scaffold Diversity and Molecular Complexity, ADVANCED SYNTHESIS & CATALYSIS, 2019, 通讯作者
(89) Rhodium(III)-Catalyzed 4+2 Annulation via C-H Activation: Synthesis of Multi-Substituted Naphthalenone Sulfoxonium Ylides, MOLECULES, 2019, 通讯作者
(90) Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia, ACTA PHARMACEUTICA SINICA B, 2019, 通讯作者
(91) Design,synthesis,and biological evaluation of novel tetrahydroprotoberberine derivatives(THPBs) as proprotein convertase subtilisin/kexin type 9(PCSK9)modulators for the treatment of hyperlipidemia, ACTA PHARMACEUTICA SINICA B, 2019, 通讯作者
(92) Identification of novel inhibitors of histone acetyltransferase hMOF through high throughput screening, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 通讯作者
(93) N-Heterocyclic Carbene Catalyzed Enantioselective 3+2 Dearomatizing Annulation of Saturated Carboxylic Esters with N-Iminoisoquinolinium Ylides, JOURNAL OF ORGANIC CHEMISTRY, 2018, 通讯作者
(94) Regio-selective and stereo-selective hydrosilylation of internal alkynes catalyzed by ruthenium complexes, RSC ADVANCES, 2018, 通讯作者
(95) Cobalt(iii)-catalyzed site-selective C-H amidation of pyridones and isoquinolones, RSC ADVANCES, 2018, 通讯作者
(96) A novel series of 4-methyl substituted pyrazole derivatives as potent glucagon receptor antagonists: Design, synthesis and evaluation of biological activities, BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 通讯作者
(97) Rh(III)-Catalyzed C-H Activation of Benzoylacetonitriles and Tandem Cyclization with Diazo Compounds to Substituted Benzodechromenes, ORGANIC LETTERS, 2018, 通讯作者
(98) Configurationally Stable (S)- and (R)--Methylproline-Derived Ligands for the Direct Chemical Resolution of Free Unprotected (3)-Amino Acids, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2018, 通讯作者
(99) Design, synthesis, and biological evaluation of 2-(phenoxyaryl)-3-urea derivatives as novel P2Y(1) receptor antagonists, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 通讯作者
(100) 先导化合物结构优化策略(六)——改善化合物血浆稳定性, Lead compound optimization strategy (6)-improving the plasma stability, 药学学报, 2018, 第 3 作者
(101) Structure-Based Design of 1-Heteroary1-1,3-propanediamine Derivatives as a Novel Series of CC-Chemokine Receptor 5 Antagonists, JOURNAL OF MEDICINAL CHEMISTRY, 2018, 通讯作者
(102) Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist, CELL DISCOVERY, 2018, 第 15 作者
(103) Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno3′,2′:3,4pyrido1,2-bisoquinoline and 5,8,12,12a-tetrahydro-6H-thieno2′,3′:4,5pyrido2,1-aisoquinoline derivatives as cellular activators of adenosine 5′-monophosphate-activated protein kinase (AMPK), BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 通讯作者
(104) Construction of highly enantiopure beta,beta-diaryl substituted glycine containing two contiguous stereocenters via asymmetric 1,6-conjugate addition, TETRAHEDRON, 2018, 通讯作者
(105) 不对称合成手性3,5-二取代脯氨酸及其衍生物, Asymmetric Synthesis of 3,5-Disubstituted Prolines, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2018, 通讯作者
(106) 不对称合成手性3,5-二取代脯氨酸及其衍生物, Asymmetric Synthesis of 3,5-Disubstituted Prolines, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2018, 通讯作者
(107) Discovery of thiophene-containing biaryl amide derivatives as novel glucagon receptor antagonists, CHEMICAL BIOLOGY & DRUG DESIGN, 2018, 通讯作者
(108) Chemical Resolution of C,N-Unprotected alpha-Substituted beta-Amino Acids Using Stable and Recyclable Proline-Derived Chiral Ligands, JOURNAL OF ORGANIC CHEMISTRY, 2018, 通讯作者
(109) Catalytic and catalyst-free diboration of alkynes, ORGANIC CHEMISTRY FRONTIERS, 2017, 通讯作者
(110) Recent approaches for asymmetric synthesis of alpha-amino acids via homologation of Ni(II) complexes, AMINOACIDS, 2017, 通讯作者
(111) Propargyl Alcohols as One-Carbon Synthons: Redox-Neutral Rhodium(III)-Catalyzed C-H Bond Activation for the Synthesis of Isoindolinones Bearing a Quaternary Carbon, ORGANIC LETTERS, 2017, 通讯作者
(112) Analysis of crystallographic structures of Ni(II) complexes of a-amino acid Schiff bases: elucidation of the substituent effect on stereochemical preferences, DALTON TRANSACTIONS, 2017, 通讯作者
(113) Asymmetric Synthesis of Chiral a-Substituted Mercaptoglycine Derivatives via α-Sulfenylation of Ni(ll) Complex of Glycine and S-Substituted 4-Methylbenzenesulfonothioate, Asymmetric Synthesis of Chiral a-Substituted Mercaptoglycine Derivatives via α-Sulfenylation of Ni(ll) Complex of Glycine and S-Substituted 4-Methylbenzenesulfonothioate, 中国化学:英文版, 2017, 第 5 作者
(114) Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer, JOURNAL OF MEDICINAL CHEMISTRY, 2017, 通讯作者
(115) Ruthenium-Catalyzed Redox-Neutral 4+1 Annulation of Benzamides and Propargyl Alcohols via C-H Bond Activation, ACS CATALYSIS, 2017, 通讯作者
(116) Construction of highly enantioenriched spirocyclopentaneoxindoles containing four consecutive stereocenters via thiourea-catalyzed asymmetric Michael–Henry cascade reactions, BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2017, 通讯作者
(117) Aspirin Inhibits Cancer Metastasis and Angiogenesis via Targeting Heparanase, CLINICAL CANCER RESEARCH, 2017, 第 14 作者
(118) Asymmetric Synthesis of Chiral alpha-Substituted Mercaptoglycine Derivatives via alpha-Sulfenylation of Ni(II) Complex of Glycine and S-Substituted 4-Methylbenzenesulfonothioate, CHINESE JOURNAL OF CHEMISTRY, 2017, 通讯作者
(119) The Second-generation of Highly Potent Hepatitis C Virus (HCV) NS3/4A Protease Inhibitors: Evolutionary Design Based on Tailor-made Amino Acids, Synthesis and Major Features of Bio-activity, CURRENT PHARMACEUTICAL DESIGN, 2017, 通讯作者
(120) 金属催化的碳-杂键对炔键的加成反应研究进展, Research Progress in Metal-Catalyzed Addition of Carbon-Hetero Bonds to Alkynes, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2017, 通讯作者
(121) Recent Advances in the Synthesis of Heterocycles via Gold-catalyzed Cascade Reactions: A Review, CURRENT ORGANIC CHEMISTRY, 2017, 通讯作者
(122) Rh(iii)-catalyzed c-h cyclization of arylnitrones with diazo compounds: access to 3-carboxylate substituted n-hydroxyindoles, JOURNAL OF ORGANIC CHEMISTRY, 2017, 通讯作者
(123) Ruthenium(II)-Catalyzed Redox-Neutral 3+2 Annulation of Indoles with Internal Alkynes via C-H Bond Activation: Accessing a Pyrroloindolone Scaffold, JOURNAL OF ORGANIC CHEMISTRY, 2017, 通讯作者
(124) Asymmetric Synthesis of Aromatic and Hetero-Aromatic α-Amino Acids Using Recyclable Axially Chiral Ligand., European Journal of Organic Chemistry., 2016, 通讯作者
(125) Next Generation of Fluorine-containing Pharmaceuticals Compounds Currently in Phase II-III Clinical Trials of Major Pharmaceutical Companies; New Structural Trends and Therapeutic Aeas., Chemical Reviews., 2016, 通讯作者
(126) Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening, EUROPEANJOURNALOFMEDICINALCHEMISTRY, 2016, 第 14 作者
(127) Design, synthesis, structure–activity relationships, and docking studies of pyrazole-containing derivatives as a novel series of potent glucagon receptor antagonists, BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 通讯作者
(128) Recent progress in the small-molecule therapeutics for Ebola virus (EBOV) disease treatment. Synthetic profiles of three unique drugs: favipiravir, BCX-4430, and brincidofovir., European Journal of Organic Chemistry., 2016, 通讯作者
(129) Highly selective intramolecular addition of c-n and s-n bonds to alkynes catalyzed by palladium: a practical access to two distinct functional indoles, RSC ADVANCES, 2016, 通讯作者
(130) Asymmetric Synthesis of Aromatic and Heteroaromatic -Amino Acids Using a Recyclable Axially Chiral Ligand, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2016, 通讯作者
(131) Synthesis and Anti-HIV-1 Activity Evaluation for Novel 3a,6a-Dihydro-1 H -pyrrolo3,4- c pyrazole-4,6-dione Derivatives, MOLECULES, 2016, 通讯作者
(132) 先导化合物结构优化策略(五) ——降低药物hERG心脏毒性, 药学学报, 2016, 第 3 作者
(133) One-pot N-glycosylation remodeling of IgG with non-natural sialylglycopeptides enables glycosite-specific and dual-payload antibody-drug conjugates., ORGANIC & BIOMOLECULAR CHEMISTRY, 2016, 第 9 作者
(134) Asymmetric Synthesis of Aromatic and Heteroaromatic alpha-Amino Acids Using a Recyclable Axially Chiral Ligand (vol 2016, pg 999, 2016), EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2016, 通讯作者
(135) N-Heterocyclic Carbene Catalytic 4+2 Cyclization of 3-Alkylenyloxindoles with Enals: gamma-Carbon Activation for Enantioselective Assembly of Spirocarbocyclic Oxindoles, JOURNAL OF ORGANIC CHEMISTRY, 2016, 通讯作者
(136) Recyclable Ligands for the Non-Enzymatic Dynamic Kinetic Resolution of Challenging a-Amino Acids., Angewandte Chemie International Edition., 2015, 通讯作者
(137) Diversity-oriented synthesis and its application in drug discovery., Acta Pharmaceutica Sinica., 2015, 通讯作者
(138) Design, synthesis and biological evaluation of isoquinoline-based derivates as novel histone deacetylase inhibitors., Bioorganic & Medicinal Chemistry., 2015, 通讯作者
(139) Site-specific indolation of proline-based peptides via copper(II)-catalyzed oxidative coupling of tertiary amine N-oxides, CHEMICAL COMMUNICATIONS, 2015, 第 5 作者
(140) 多样性合成及其在药物发现中的应用, Diversity-oriented synthesis and its application in drug discovery, 药学学报, 2015, 第 3 作者
(141) Palladium-catalyzed picolinamide-directed coupling of C(sp(2))-H and C(sp(2))-H: a straightforward approach to quinolinone and pyridone scaffolds, CHEMICAL COMMUNICATIONS, 2015, 通讯作者
(142) Fluorescent Coumarin-Artemisinin Conjugates as Mitochondria-Targeting Theranostic Probes for Enhanced Anticancer Activities, CHEMISTRY-A EUROPEAN JOURNAL, 2015, 第 9 作者
(143) The facile construction of phthalazin-1(2H)-one scaffold via copper-mediated C-H(sp2)/C-H(sp) coupling under mild conditions., Beilstein Journal of Organic Chemistry., 2015, 通讯作者
(144) γ-Carbon Activation Through N-Heterocyclic Carbene/Brønsted Acids Cooperative Catalysis: A Highly Enantioselective Route to δ-Lactams., Organic Letters., 2015, 通讯作者
(145) 通过串联反应不对称合成氧化吲哚螺环化合物的研究进展., 有机化学., 2015, 通讯作者
(146) Palladium-Catalyzed C2-Acylation of Indoles with α-Diketones Assisted by the Removable N-(2-Pyrimidyl) Group., European Journal of Organic Chemistry., 2015, 通讯作者
(147) Asymmetric Synthesis of (2S,3S)-alpha-(1-Oxoisoindolin-3-yl)glycines under Low-Basicity "Kinetic" Control, JOURNALOFORGANICCHEMISTRY, 2015, 第 6 作者
(148) Direct access to pyrido/pyrrolo2,1-bquinazolin-9(1H)-ones through silver-mediated intramolecular alkyne hydroamination reactions, BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2015, 第 8 作者
(149) Asymmetric synthesis of α-(1-oxoisoindolin-3-yl)glycine: synthetic and mechanistic challenges., ChemComm., 2015, 通讯作者
(150) Palladium-Catalyzed C2-Acylation of Indoles with alpha-Diketones Assisted by the Removable N-(2-Pyrimidyl) Group, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2015, 第 5 作者
(151) Palladium-catalyzed intramolecular addition of C-N bond to alkynes: a novel approach to 3-diketoindoles, RSC ADVANCES, 2015, 通讯作者
(152) Design, Synthesis, and Biological Evaluation of NovelImidazo1,2- a pyridine Derivatives as Potentc-Met Inhibitors, ACS MEDICINAL CHEMISTRY LETTERS, 2015, 其他(合作组作者)
(153) Chemical Dynamic Thermodynamic Resolution and S/R Interconversion of Unprotected Unnatural Tailor-made α‑Amino Acids., Journal of Organic Chemistry., 2015, 通讯作者
(154) Asymmetric Synthesis of (2S,3S)‑α-(1-Oxoisoindolin-3-yl)glycines under Low-Basicity "Kinetic" Control., Journal of Organic Chemistry., 2015, 通讯作者
(155) JNJ-40411813合成工艺研究, Improved synthetic process of JNJ-40411813, 中国药物化学杂志, 2015, 第 6 作者
(156) Discovery and Optimization of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Pharmacophore- and Docking-Based Virtual Screening., JOURNAL OF MEDICINAL CHEMISTRY, 2015, 第 18 作者
(157) Three-Step One-Pot Synthesis of 1,4-Dihydropyrazolo 4,3-b indoles Using Copper Catalysis, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2014, 通讯作者
(158) 等排置换及其在药物分子设计中的应用, 中国药物化学杂志, 2014, 第 2 作者
(159) 先导化合物结构优化策略三通过化学修饰改善水溶性, 药学学报, 2014, 第 4 作者
(160) 先导化合物结构优化策略四改善化合物的血脑屏障通透性, 药学学报, 2014, 第 4 作者
(161) 先导化合物结构优化策略(二) —— 结构修饰降低潜在毒性, 药学学报, 2014, 第 4 作者
(162) A simple copper-catalyzed two-step one-pot synthesis of indolo1,2- a quinazoline, BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2014, 通讯作者
(163) A Mannich/cyclization cascade process for the asymmetric synthesis of spirocyclic thioimidazolidineoxindoles, CHEMICAL COMMUNICATIONS, 2014, 第 5 作者
(164) 含氟氨基酸和内酰胺的合成研究进展, 有机化学, 2013, 第 3 作者
(165) 磷酸酯前药在药物研究中的应用, 药学学报, 2013, 第 6 作者
(166) De Novo Design, Synthesis and Evaluation of Benzylpiperazine Derivatives as Highly Selective Binders of Mcl-1, CHEMMEDCHEM, 2013, 第 10 作者
(167) 高效合成技术在药物研发中的应用, 药学学报, 2013, 第 4 作者
(168) 先导化合物结构优化策略一改变代谢途径提高代谢稳定性, 药学学报, 2013, 第 2 作者
(169) Gold-catalyzed Michael addition/intramolecular annulation cascade: an effective pathway for the chemoselective- and regioselective synthesis of tetracyclic indole derivatives in water, GREEN CHEMISTRY, 2013, 第 5 作者
(170) Highly diastereoselective synthesis of 3-indolylglycines via an asymmetric oxidative heterocoupling reaction of a chiral nickel(II) complex and indoles, CHEMICALCOMMUNICATIONS, 2013, 通讯作者
(171) 拉尼那米韦辛酯的合成工艺研究, Improved synthesis of laninamivir octanoate, 中国药物化学杂志, 2012, 第 5 作者
(172) 多巴胺各受体亚型的配体研究进展, 中国药物化学杂志, 2012, 第 6 作者
(173) Structural modifications of 5,6-dihydroxypyrimidines with anti-HIV activity, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 第 9 作者
(174) 新化学实体的发现和早期评价, Discovery and early evaluation of new chemical entities, 中国药学:英文版, 2012, 第 4 作者
(175) 拉尼那米韦辛酯的合成工艺研究, Improved synthesis of laninamivir octanoate, 中国药物化学杂志, 2012, 第 5 作者
(176) Diastereoselective Michael reaction of chiral nickel(II) glycinate with nitroalkenes for asymmetric synthesis of beta-substituted alpha,gamma-diaminobutyric acid derivatives in water, AMINO ACIDS, 2012, 通讯作者
(177) Discovering potent inhibitors against c-Met kinase: molecular design, organic synthesis and bioassay, ORGANIC & BIOMOLECULAR CHEMISTRY, 2012, 第 9 作者
(178) Recent advances in the gold-catalyzed additions to C–C multiple bonds, BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2011, 通讯作者
(179) Computational screening for active compounds targeting protein sequences: methodology and experimental validation., JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2011, 第 6 作者
(180) Silver-catalyzed intramolecular hydroamination of alkynes in aqueous media: ef?cient and regioselective synthesis for fused benzimidazoles, 2011, 通讯作者
(181) An Effective Synthetic Entry to Fused Benzimidazoles via Iodocyclization, ADVANCED SYNTHESIS & CATALYSIS, 2011, 通讯作者
(182) 氟原子在药物分子设计中的应用, Application of Fluorine in Drug Design, 有机化学, 2011, 第 2 作者
(183) Synthesis of Pyrrolo1,2-aquinoxalines via Gold(I)-Mediated Cascade Reactions, ACS COMBINATORIAL SCIENCE, 2011, 通讯作者
(184) 四氢原小檗碱类衍生物的设计、合成及抗多巴胺D1受体的活性研究, 2011, 第 7 作者
(185) Asymmetric Synthesis of Sterically and Electronically Demanding Linear omega-Trifluoromethyl Containing Amino Acids via Alkylation of Chiral Equivalents of Nucleophilic Glycine and Alanine, JOURNAL OF ORGANIC CHEMISTRY, 2011, 第 6 作者
(186) The Preparation of α-Alkyl-β-Amino Acids via β-Alanine Ni(II) Complex, Journal of Organic Chemistry, 2011, 通讯作者
(187) Iron Deprivation Caused by a Novel Iron Chelator, Thiosemicarbazone-24, Suppresses Hepatocellular Carcinoma in vitro and in Mouse Models, Clinical Cancer Research, 2011, 
(188) Cell-Permeable Iminocoumarine-Based Fluorescent Dyes for Mitochondria, ORGANIC LETTERS, 2011, 第 8 作者
(189) 银催化有机合成反应的研究进展, Recent Advances in Silver-Mediated Organic Synthesis Reactions, 化学进展, 2011, 第 1 作者
(190) Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design, JOURNAL OF VIROLOGY, 2011, 第 8 作者
(191) Apply Nickel(II) Complexes to Efficient Synthesis of α-, or β-Amino Acids, Chimia, 2011, 通讯作者
(192) Design and Synthesis of First-in-Class Small Molecule RhoA Inhibitors: A New Promising Therapy for Cardiovascular Diseases, Journal of Medicinal Chemistry, 2011, 通讯作者
(193) Silver-catalyzed intramolecular hydroamination of alkynes in aqueous media: efficient and regioselective synthesis for fused benzimidazoles, GREEN CHEMISTRY, 2011, 第 8 作者
(194) Synthesis of 4-Aryl-2(5H)-furanones by Au (Ι)-Catalyzed Intramolecular Annulation, Advanced Synthesis Catalysis, 2011, 通讯作者
(195) Silver- and Gold-Mediated Domino Transformation: A Strategy for Synthesizing Benzoeindolo1,2-apyrrolo/pyrido2,1-c1,4-diazepine-3,9-diones, JOURNAL OF ORGANIC CHEMISTRY, 2011, 通讯作者
(196) Synthesis of 2-Phenylnaphthalenes through Gold-Catalyzed Dimerization via a Highly Selective Carbon Nucleophile Pathway, JOURNAL OF ORGANIC CHEMISTRY, 2011, 通讯作者
(197) PH006, a novel and selective Src kinase inhibitor, suppresses human breast cancer growth and metastasis in vitro and in vivo, BREAST CANCER RESEARCH AND TREATMENT, 2011, 第 8 作者
(198) Molecular Basis of NDM-1, a New Antibiotic Resistance Determinant, PLOS ONE, 2011, 第 10 作者
(199) Highly Diastereo- and Enantioselective Synthesis of syn-β-Substituted Tryptophans via the Reaction of a Chiral Equivalent of Nucleophilic Glycine and Sulfonylindoles, Chem.Comm, 2011, 通讯作者
(200) Identification and synthesis of N′-(2-oxoindolin-3-ylidene)hydrazide derivatives against c-Met kinase, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 通讯作者
(201) Enterovirus 71 and Coxsackievirus A16 3C proteases: binding to Rupintrivir and their substrate, and anti-hand, foot, and mouth disease virus drug design., Journal of Virology, 2011, 通讯作者
(202) Structural and Functional Analysis of Laninamivir and its Octanoate Prodrug Reveals Group Specific Mechanisms for Influenza NA Inhibition, PLOS PATHOGENS, 2011, 
(203) A Series of alpha-Heterocyclic Carboxaldehyde Thiosemicarbazones Inhibit Topoisomerase II alpha Catalytic Activity, JOURNAL OF MEDICINAL CHEMISTRY, 2010, 第 14 作者
(204) One-pot Approach for C-C Bond Formation through Ru-amino Complex Catalyzed Tandem Aldol Reaction/Hydrogenation, Synthesis, 2010, 15, 2577-2582, 2010, 通讯作者
(205) A Nonproton Ligand Sensor in the Acid-Sensing Ion Channel, NEURON, 2010, 第 7 作者
(206) Gold(I)-Catalyzed One-Pot Tandem Coupling/Cyclization: An Efficient Synthesis of Pyrrolo-/Pyrido2,1-bbenzod1,3oxazin-1-ones, ADVANCED SYNTHESIS & CATALYSIS, 2010, 通讯作者
(207) 基于结构的抗流感病毒神经氨酸酶抑制剂的设计和研发, 生物产业技术, 2010, 第 3 作者
(208) Novel thiophene derivatives as PTP1B inhibitors with selectivity and cellular activity, BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 通讯作者
(209) Most Efficient Routes for the Synthesis of alpha,beta-Diamino Acid-Derived Compounds, CURRENT PHARMACEUTICAL DESIGN, 2010, 通讯作者
(210) Gold(I)-Catalyzed Cascade for Synthesis of Pyrrolo1,2-a:2 ',1 '-c-/Pyrido2,1-cpyrrolo1,2-aquinoxalinones, ADVANCED SYNTHESIS & CATALYSIS, 2010, 通讯作者
(211) Structural Optimization and Biological Evaluation of Substituted Bisphenol A Derivatives as beta-Amyloid Peptide Aggregation Inhibitors, JOURNAL OF MEDICINAL CHEMISTRY, 2010, 第 15 作者
(212) Silver- and Gold-Mediated Intramolecular Cyclization to Substituted Tetracyclic Isoquinolizinium Hexafluorostilbates, JOURNAL OF ORGANIC CHEMISTRY, 2010, 通讯作者
(213) HIV整合酶抑制剂的研究进展, Research Progress in HIV Integrase Inhibitors, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2010, 第 8 作者
(214) Discovery of novel purine derivatives with potent and selective inhibitory activity against c-Src tyrosine kinase, BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 第 7 作者
(215) HIV整合酶抑制剂的研究进展, Research Progress in HIV Integrase Inhibitors, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2010, 第 8 作者
(216) Highly α-selective synthesis of sialyl hydantoins by regiospecific domino condensationO--N acyl migration N-sialylation of carbodiimides with peracetylated sialic acid, Journal of Organic Chemistry, 2010, 通讯作者
(217) Metal-Free Synthesis of 2-Substituted (N, O, C) Benzothiazoles via an Intramolecular C-S Bond Formation, JOURNAL OF COMBINATORIAL CHEMISTRY, 2010, 通讯作者
(218) Efficient Synthesis of Symmetrical α,α-Disubstituted β-Amino Acids and α,α-Disubstituted Aldehydes via Dialkylation of Nucleophilic β-Alanine Equivalen, Journal of Organic Chemistry, 2010, 75, 1717-1722, 2010, 通讯作者
(219) Regioselective Synthesis of 3-Benzazepinones and Unexpected 5-Bromo-3-benzazepinones, JOURNAL OF ORGANIC CHEMISTRY, 2010, 通讯作者
(220) The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2010, 
(221) 唾液酸糖苷化方法学研究, Advances in O-Sialylation, 化学进展, 2010, 第 6 作者
(222) Gold(I)-Catalyzed Tandem Transformation: A Simple Approach for the Synthesis of Pyrrolo/Pyrido2,1-a1,3benzoxazinones and Pyrrolo/Pyrido2,1-aquinazolinones, JOURNAL OF ORGANIC CHEMISTRY, 2010, 通讯作者
(223) Ligand-free iron/copper cocatalyzed N-arylations of aryl halides with amines under microwave irradiation, GREEN CHEMISTRY, 2010, 第 7 作者
(224) Metal-free tandem reaction in water: An efficient and regioselective synthesis of 3-hydroxyisoindolin-1-ones, GREEN CHEMISTRY, 2010, 第 6 作者
(225) B5, a novel pyrrole-substituted indolinone, exerts potent antitumor efficacy through G2/M cell cycle arrest, INVESTIGATIONAL NEW DRUGS, 2010, 第 9 作者
(226) 新型Src激酶抑制剂PH006的抗肿瘤作用研究, 2009, 第 4 作者
(227) Raltegravir的合成工艺研究(英文), Improved synthesis of raltegravir, 中国药科大学学报, 2009, 第 7 作者
(228) raltegravir的合成工艺研究, 中国药科大学学报, 2009, 第 7 作者
(229) β-氨基酸的合成:等当体方法的应用, Synthesis of β-Amino Acid--The Applications of β-Amino Acid Equivalents, 有机化学, 2009, 第 6 作者
(230) J MED CHEM, 2009, 
(231) 缩氨基硫脲类新化合物TSC的抗肿瘤作用及其分子机制研究, 2009, 第 8 作者
(232) 扎那米韦的合成工艺研究, Improved synthesis of zanamivir, 中国药物化学杂志, 2008, 第 6 作者
(233) Ni(Ⅱ)螯合物在氨基酸合成中的应用, Application of Ni(Ⅱ) Chelate to Amino Acid Synthesis, 有机化学, 2008, 第 3 作者
(234) 药物新分子实体的发现与优化策略, 2008, 第 1 作者
(235) 先导化合物的发现——整合计算机虚拟筛选、化学合成和生物测试方法, Discovering Potential Drug Leads v/a Docking, Synthesis and Bioassay, 化学进展, 2007, 第 7 作者
(236) Transformation of aryl acyloin O-alkyl and O-phenyl derivatives to ketones, SYNTHETIC COMMUNICATIONS, 2007, 通讯作者
(237) Microwave-assisted rapid synthesis of 2,6,9-substituted purines, JOURNAL OF COMBINATORIAL CHEMISTRY, 2007, 通讯作者
(238) 亲环素A抑制剂研究进展, Research progress of cyclophilin A inhibitors, 中国药科大学学报, 2006, 第 3 作者
(239) 一个潜在的糖尿病新靶标gpr40, 生命科学, 2006, 第 3 作者
(240) Negative effects of Microcystis blooms on the crustacean plankton in an enclosure experiment in the subtropical China, Negative effects of Microcystis blooms on the crustacean plankton in an enclosure experiment in the subtropical China, 环境科学学报:英文版, 2005, 第 4 作者
(241) 靶标及药物发现中的超级计算, 2002, 第 4 作者
(242) 基质金属蛋白酶抑制剂设计的研究进展, 化学进展, 2001, 第 2 作者
(243) 1,3—偶极环加成反应合成△^2—吡唑啉羧酸类化合物, 中国药科大学学报, 2000, 第 4 作者
(244) 甲烷磺酰胺苯乙胺类化合物的合成及抗心律失常活性的研究(Ⅱ), 中国药科大学学报, 1999, 第 6 作者
(245) 甲磺酰胺苯乙胺类化合物抗心律失常活性的定量构效关系研究(1), 中国药科大学学报, 1998, 第 2 作者
发表著作
( 1 ) 药物基因组学-寻求个性化治疗, Pharmacogenomics - The Search for Individualized Therapies, 科学出版社, 2005-07, 第 4 作者
( 2 ) 基于活性化合物和分子靶标的集中组合库设计:药物发现的方法和应用, Focused Library Design Based on Hit and Target Structures:Method and Application in Drug Discovery, John Wiley Sons, 2007-07, 第 4 作者
( 3 ) 新分子实体的发现与优化策略, The discovery and optimization strategies of new molecular entities , 北京化学工业出版社, 2009-07, 第 1 作者
( 4 ) 高等药物化学, Advanced Medicinal Chemistry, 科学出版社, 2011-07, 第 4 作者
( 5 ) 高等药物化学, Advanced Medicinal Chemistry, 科学出版社, 2011-07, 第 1 作者
( 6 ) 微波在有机合成和药物研发中的作用, Microwave Heating in Organic Synthesis and Drug Discovery, InTech, 2011-07, 第 1 作者
( 7 ) 个性化药物——新药研发的未来, 上海科学技术文献出版社, 2020-06, 第 3 作者
( 8 ) 创新药物研发经纬, 化学工业出版社, 2020-10, 第 3 作者
( 9 ) 高等药物化学-创新药物研究原理与案例, 人民卫生出版社, 2021-01, 第 3 作者
( 10 ) 化学创新药物研发, 上海交通大学出版社, 2021-05, 第 3 作者

科研活动

   
科研项目
( 1 ) 新型钾离子通道阻滞剂的发现及其亚型的选择性和功能研究, 负责人, 国家任务, 2008-01--2011-12
( 2 ) 抗糖尿病类LJN系列新药候选物的临床前研究, 负责人, 国家任务, 2012-01--2015-12
( 3 ) 基于蛋白质调控网络的系统生物学研究, 负责人, 国家任务, 2015-01--2019-12
( 4 ) S1P在肿瘤细胞糖脂代谢异常及非可控性炎症向肿瘤癌转化中的分子调控, 负责人, 国家任务, 2013-01--2016-12
( 5 ) 疾病网络动力学干预与药物设计, 负责人, 国家任务, 2015-01--2019-12
( 6 ) 含氮多环类药性化合物库的构建与创新药物发现及可视化研究, 负责人, 国家任务, 2017-01--2021-12
( 7 ) 金属螯合物不对称合成非天然氨基酸及其在创新药物发现与合成中的研究, 负责人, 国家任务, 2017-01--2021-12
( 8 ) 多维度抗冠状病毒先导化合物发现与作用机制研究, 负责人, 国家任务, 2022-01--2026-12
( 9 ) 降血脂活性化合物对PCSK9的表观遗传调控机制研究, 负责人, 国家任务, 2020-01--2022-12
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