基本信息
陈东英  女  博导  中国科学院上海药物研究所
电子邮件: dychen00@hotmail.com
通信地址: 上海浦东张江祖冲之路555号
邮政编码: 201203

招生信息

   
招生专业
100704-药物分析学
招生方向
色谱分析,杂质分析,新药质量标准

工作经历

   
工作简历
1999-09~现在, 上海药物研究所, 研究员,课题组长
1997-01~1999-04,厦门大学生物学系, 博士后

出版信息

   
发表论文
(1) Bioluminescence imaging of carbon monoxide in living cells based on a selective deiodination reaction, Analyst, 2020, 通讯作者
(2) A comprehensive Multilocus Sequence Typing Scheme for Identification and Genotyping of Staphylococcus Strains, Foodborne Pathogens and Disease, 2019, 通讯作者
(3) Characterization of drug–drug salt forms of metformin and aspirin with improved physicochemical properties, CrystEngComm, 2019, 通讯作者
(4) Trace determination of mutagenic alkyl toluenesulfonate impurities via derivatization headspace–GC/MS in an active pharmaceutical ingredient of a candidate drug, J. Pharm. Biomed. Anal., 2018, 通讯作者
(5) 药物中磺酸酯类基因毒性杂质研究进展, 色谱, 2018, 通讯作者
(6) Pharmacokinetics and disposition of anlotinib, an oral tyrosine kinase inhibitor, in experimental animal species, Acta Pharmacol Sin, 2018, 其他(合作组作者)
(7) Phosphoglycerate Mutase 1 Promotes Cancer Cell Migration Independent of its Metabolic Activity, Oncogene, 2017, 其他(合作组作者)
(8) Crystal structures and physicochemical properties of amisulpride polymorphs, J. Pharm. Biomed. Anal., 2017, 通讯作者
(9) Application of capillary electrophoresis-frontal analysis for comparative evaluation of the binding interaction of captopril with human serum albumin in the absence and presence of hydrochlorothiazide, J. Pharm. Biomed. Anal., 2015, 通讯作者
(10) Characterization of interactions between methoxatin disodium salt and HSA by pressure-assisted capillary electrophoresis (PACE)/frontal analysis (FA) and circular dichroism (CD) spectroscopy, Biomedical Chromatography, 2015, 通讯作者
(11) Determination of pKa Values of A Triptolide Derivative and Its Impurities By Pressure-Assisted Capillary Electrophoresis, J. Pharm. Biomed. Anal., 2014, 通讯作者
(12) RP - HPLC Determination of Irinotecan Hydrochloride( CPT - 11) and Its Related Substances, Chin. J. Pharm. Anal., 2013, 通讯作者
(13) Polymorphism of the 5R-5-Hydroxytriptolide, Acta Pharm. Sin., 2011, 通讯作者
(14) Application of Phase Optimized Liquid Chromatography for Related Substances Detection in New Drug Candidate of Tripterygiumforrestii Derivative, Chin J. Anal. Chem., 2011, 通讯作者
(15) Application of Phase Optimized Liquid Chromatography to Oligopeptide Separations, J. Pharm. Biomed. Anal., 2009, 通讯作者
(16) Study on The Hydrolysis Reaction of a Novel Camptothecin Derivative (L-P) Using Capillary Zone Electrophoresis, Chin. J. Anal. Chem., 2009, 通讯作者
(17) Study on The Hydrolysis Reaction of a Novel Camptothecin Derivative (L-P) Using Capillary Zone Electrophoresis, Chin. J. Anal. Chem., 2009, 通讯作者
(18) Application of Headspace Solid Phase Microextraction for Noncovalent Interaction of Borneol Binding to Human Serum Albumin, Acta Pharmacol. Sin., 2009, 通讯作者
(19) Investigating Noncovalent Interactions of Rutin - Serum Albumin by Capillary Electrophoresis - Frontal Analysis, J. Pharm. Biom. Anal., 2008, 通讯作者
(20) Development and Validation of A Sensitive Liquid Chromatography–Tandem Mass Spectrometry Method for The Determination of Paeoniflorin in Rat Brain and Its Application to Pharmacokinetic Study, J. Chromatogr. B, 2007, 通讯作者
发表著作
( 1 ) 10000个科学难题 (医学卷), 科学出版社, 2011-08, 第 5 作者

科研活动

   
科研项目
( 1 ) 科技部十二五新药重大专项, 参与, 国家任务, 2014-08--2017-08
( 2 ) 中科院重点部署项目, 参与, 中国科学院计划, 2014-09--2017-09
( 3 ) GV185, 负责人, 企业委托, 2015-09--2018-09
( 4 ) SM934, 负责人, 企业委托, 2016-01--2026-01
( 5 ) PQQ, 负责人, 企业委托, 2014-05--2017-05