基本信息
陈东英  女  博导  中国科学院上海药物研究所
电子邮件: dychen@simm.ac.cn
通信地址: 上海浦东张江祖冲之路555号
邮政编码: 201203

招生信息

   
招生专业
100704-药物分析学
招生方向
药物质量控制,色谱方法学,晶型表征,药-药共晶筛选,药物降解动力学与热力学机制,成药性理化参数

工作经历

   
工作简历
1999-09~现在, 上海药物研究所, 研究员,课题组长
1997-01~1999-04,厦门大学生物学系, 博士后

专利与奖励

   
专利成果
( 1 ) 一种L-α-甘油磷酰胆碱中微量位置异构体杂质的检测方法, 2022, 第 1 作者, 专利号: CN114414610A

( 2 ) 一种L-α-甘油磷酰胆碱有关物质的检测方法, 2019, 第 1 作者, 专利号: CN110133119A

( 3 ) 一种测定药物中对甲苯磺酸甲酯的方法, 2018, 第 1 作者, 专利号: CN107632078A

( 4 ) 测定氯仿、二氯甲烷、三氯乙烯和1,4-二氧六环残留量的气相色谱双检测器方法以及系统, 2008, 第 1 作者, 专利号: CN101162217A

( 5 ) 逆流聚焦电泳装置, 2001, 第 2 作者, 专利号: CN1068944C

出版信息

   
发表论文
(1) Effects of aqueous extracts and volatile oils prepared from Huaxiang Anshen decoction on p-chlorophenylalanine-induced insomnia mice, JOURNAL OF ETHNOPHARMACOLOGY, 2024, 第 6 作者
(2) Separation and structural characterization of unknown impurity in vancomycin by two-dimensional preparative liquid chromatography, LC-MS and NMR, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023, 第 5 作者  通讯作者
(3) Investigation of atropisomeric transformation of a novel PDE4 inhibitor with tetrahydroisoquinoline-based amide group and its primary study of binding to HSA, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2022, 第 7 作者  通讯作者
(4) "Two-birds-one-stone" colon-targeted nanomedicine treats ulcerative colitis via remodeling immune microenvironment and anti-fibrosis, JOURNAL OF NANOBIOTECHNOLOGY, 2022, 第 9 作者
(5) Discovery of CECR2 Bromodomain Inhibitors with High Selectivities over BPTF Bromodomain, CHINESE JOURNAL OF CHEMISTRY, 2022, 第 8 作者
(6) 基因毒性杂质甲磺酸酯稳定性及水解反应动力学研究, Study on the stability and hydrolysis kinetics of genotoxic impurities methanesulfonates, 药物分析杂志, 2021, 第 6 作者
(7) Intrinsic stability study of L-alpha-glycerylphosphorylcholine with HPLC method development and validation, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2020, 第 5 作者  通讯作者
(8) Lactoferrin-mediated macrophage targeting delivery and patchouli alcohol-based therapeutic strategy for inflammatory bowel diseases, Lactoferrin-mediated macrophage targeting delivery and patchouli alcohol-based therapeutic strategy for inflammatory bowel diseases, ACTA PHARMACEUTICA SINICA B, 2020, 第 9 作者  通讯作者
(9) Bioluminescence imaging of carbon monoxide in living cells based on a selective deiodination reaction, ANALYST, 2020, 第 4 作者
(10) 微量电位滴定法测定普瑞巴林的解离常数和油水分配系数, Determination of dissociation constant and oil-water partition coefficient of pregabalin by micro-potentiometric titration, 药物分析杂志, 2020, 第 5 作者
(11) A Comprehensive Multilocus Sequence Typing Scheme for Identification and Genotyping of Staphylococcus Strains, FOODBORNE PATHOGENS AND DISEASE, 2019, 第 9 作者  通讯作者
(12) Characterization of drug-drug salt forms of metformin and aspirin with improved physicochemical properties, CRYSTENGCOMM, 2019, 第 5 作者  通讯作者
(13) Trace determination of mutagenic alkyl toluenesulfonate impurities via derivatization headspace���GC/MS in an active pharmaceutical ingredient of a candidate drug, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2018, 第 5 作者  通讯作者
(14) 药物中磺酸酯类基因毒性杂质研究进展, Advances on genotoxic impurities of sulfonate esters in pharmaceuticals, 色谱, 2018, 第 5 作者
(15) Pharmacokinetics and disposition of anlotinib, an oral tyrosine kinase inhibitor, in experimental animal species, Pharmacokinetics and disposition of anlotinib, an oral tyrosine kinase inhibitor, in experimental animal species, ACTA PHARMACOLOGICA SINICA, 2018, 第 15 作者
(16) Crystal structures and physicochemical properties of amisulpride polymorphs, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2017, 第 2 作者  通讯作者
(17) Phosphoglycerate mutase 1 promotes cancer cell migration independent of its metabolic activity, ONCOGENE, 2017, 
(18) Application of capillary electrophoresis-frontal analysis for comparative evaluation of the binding interaction of captopril with human serum albumin in the absence and presence of hydrochlorothiazide, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2015, 第 4 作者  通讯作者
(19) Characterization of interactions between methoxatin disodium salt and human serum albumin by pressure-assisted capillary electrophoresis/frontal analysis and circular dichroism spectroscopy, BIOMEDICAL CHROMATOGRAPHY, 2015, 第 2 作者  通讯作者
(20) Determination of pKavalues of a triptolide derivative and its impurities by pressure-assisted capillary electrophoresis, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 第 3 作者  通讯作者
(21) 反相离子对高效液相色谱法检查盐酸伊立替康(CPT-11)有关物质, 药物分析杂志, 2013, 第 4 作者
(22) Discovery and Mechanism Study of SIRT1 Activators that Promote the Deacetylation of Fluorophore-Labeled Substrate, JOURNAL OF MEDICINAL CHEMISTRY, 2013, 第 9 作者
(23) 固定相优化液相色谱法对候选新药雷公藤衍生物进行有关物质检查, Application of Phase Optimized Liquid Chromatography for Related Substances Detection in New Drug Candidate of Tripterygiumforrestii Derivative, 分析化学, 2011, 第 4 作者
(24) 创新候选药物晶型的质量控制研究策略探讨, 2011, 第 1 作者
(25) 固定相优化液相色谱法对候选新药雷公藤衍生物进行有关物质检查, Application of Phase Optimized Liquid Chromatography for Related Substances Detection in New Drug Candidate of Tripterygiumforrestii Derivative, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2011, 第 4 作者  通讯作者
(26) 5R-5-羟基雷公藤内酯醇的晶型制备与表征, Polymorphism of the 5R-5-hydroxytriptolide, 药学学报, 2011, 第 3 作者
(27) 固定相优化液相色谱法对候选新药雷公藤衍生物进行有关物质检查, Application of Phase Optimized Liquid Chromatography for Related Substances Detection in New Drug Candidate of Tripterygiumforrestii Derivative, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2011, 第 4 作者  通讯作者
(28) Application of phase optimized liquid chromatography to oligopeptide separations, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2010, 第 5 作者  通讯作者
(29) 固定相优化液相色谱技术应用进展, 2010, 第 1 作者
(30) 毛细管区带电泳法研究新型喜树碱衍生物的水解反应, Study on Hydrolysis Reaction of Novel Camptothecin Derivative(L-P) Using Capillary Zone Electrophoresis, 分析化学, 2009, 第 4 作者
(31) Application of headspace solid phase microextraction for study of noncovalent interaction of borneol with human serum albumin, ACTA PHARMACOLOGICA SINICA, 2009, 第 2 作者  通讯作者
(32) 药物中石油醚残留量的气相色谱检测方法学探讨, Investigation of quantitive control of residual petroleum ether in pharmaceuticals by gas capillary chromatography, 药物分析杂志, 2008, 第 3 作者
(33) Investigating noncovalent interactions of rutin ��� serum albumin by capillary electrophoresis ��� frontal analysis, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2008, 第 3 作者  通讯作者
(34) 胶束电动毛细管电泳法测定三七药材中人参皂苷Rgl,Re和Rbl的含量, 中成药, 2007, 第 2 作者
(35) Development and validation of a sensitive liquid chromatography-tandem mass spectrometry method for the determination of paeoniflorin in rat brain and its application to pharmacokinetic study, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2007, 第 8 作者  通讯作者
(36) 高效液相色谱法测定扎那米韦有关物质, 2006, 第 2 作者
(37) 顶空固相微萃取-气相色谱法测定粉尘螨舌下滴剂中丙酮的残留量, 中国生物制品学杂志, 2006, 第 2 作者
(38) 右旋糖酐铁注射液中右旋糖酐铁峰位相对分子质量的测定, Iron dextran peak molecular weight comparison determination in iron dextran injections, 中国新药与临床杂志, 2005, 第 2 作者
(39) 中英两国药典关于右旋糖酐铁注射液铁吸收度的考察方法比较, Iron Absorption Detection Method for Iron Dextran Injection Comparisons Between Chinese Pharmacopoeia and British Pharmocopoeia, 中国药品标准, 2004, 第 1 作者
(40) 粉尘螨滴剂中硫柳汞限度的比色检查, 中国生物制品学杂志, 2004, 第 4 作者
(41) 基于电迁移率差异而分离的新型聚焦电泳技术, 电化学, 1997, 第 4 作者
(42) Investigation of atropisomeric transformation of a novel PDE4 inhibitor with tetrahydroisoquinoline-based amide group and its primary study of binding to HSA, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 第 7 作者  通讯作者
(43) Effects of aqueous extracts and volatile oils prepared from Huaxiang Anshen decoction on p-chlorophenylalanine-induced insomnia mice, JOURNAL OF ETHNOPHARMACOLOGY, 第 6 作者
(44) Separation and structural characterization of unknown impurity in vancomycin by two-dimensional preparative liquid chromatography, LC-MS and NMR, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 第 5 作者  通讯作者
发表著作
( 1 ) 10000个科学难题 (医学卷), 科学出版社, 2011-08, 第 5 作者

科研活动

   
科研项目
( 1 ) SM934, 负责人, 境内委托项目, 2016-01--2026-01
( 2 ) GV185, 负责人, 境内委托项目, 2015-09--2018-09
( 3 ) 中科院重点部署项目, 参与, 中国科学院计划, 2014-09--2017-09
( 4 ) 科技部十二五新药重大专项, 参与, 国家任务, 2014-08--2017-08
( 5 ) PQQ, 负责人, 境内委托项目, 2014-05--2017-05