基本信息
范青华  男  博导  中国科学院化学研究所
电子邮件: fanqh@iccas.ac.cn
通信地址: 北京海淀中关村北一街2号
邮政编码: 100190

研究领域

       不对称催化合成
       环境友好的有机反应
       功能树状大分子的合成、组装及应用

教育背景

1989年:湘潭大学化学系 理学学士
1992年:中国科学院化学研究所 理学硕士
1998年:香港理工大学应用生物及化学系 理学博士

工作经历

1992-1998年:中国科学院化学研究所 研究实习员、助理研究员
1998-2003年:中国科学院化学研究所 副研究员
2003年-现在:中国科学院化学研究所 研究员、博士生导师。现任中国科学院 
                          分子识别与功能重点实验室常务副主任

个人获奖

(1)  2003年获得国家杰出青年基金
(2)  2005年国家自然科学二等奖(排名第二) 
(3)  2008年中国科学院“****”
(3)  2008年获国务院政府特殊津贴 
(4) 《不对称催化新概念与新方法》获中国石油和化学工业优秀出版物奖
       (图书奖)一等奖

出版信息

   
代表性论文:
[1] 范青华. Asymmetric synthesis of C1-symmetric chiral nhc ligands and their applications in asymmetric catalysis. 化学学报[J]. 2023, [2] 范青华. Asymmetric Synthesis of Chiral Seven-Membered NHCs, Their Transition-Metal Complexes and Application in Asymmetric Catalysis. SYNTHESIS-STUTTGART[J]. 2023, 55(14): 2206-2218, http://dx.doi.org/10.1055/s-0042-1751439.
[3] 范青华. Asymmetric transfer hydrogenation of naphthol and phenol derivatives with cooperative heterogeneous and homogeneous catalysis. CCS Chem[J]. 2023, [4] ZiQi Yi, Fei Chen, YanMei He, QingHua Fan. Asymmetric hydrogenation of isoquinolines with chiral cationic ruthenium diamine catalysts. TETRAHEDRON[J]. 2023, 149: http://dx.doi.org/10.1016/j.tet.2023.133736.
[5] 范青华. Tunable unsymmetrical chiral N-heterocyclic carbene ligands for highly diastereo- and enantioselective copper-catalyzed tandem borylative cyclization: ligand controlled diastereoselectivity reversal. CCS Chem[J]. 2023, [6] Yi, ZiQi, Deng, BoWen, Chen, Fei, He, YanMei, Fan, QingHua. Asymmetric hydrogenation of dibenzo-fused azepines with chiral cationic ruthenium diamine catalysts. NEW JOURNAL OF CHEMISTRY[J]. 2023, 47(24): 11492-11497, http://dx.doi.org/10.1039/d3nj01652h.
[7] 范青华. Asymmetric hydrogenation of tetrapyridine-type N-heteroarenes using phosphine-free ruthenium diamine catalysts. Chinese Journal of Chemistry[J]. 2023, [8] 范青华. Rhodium-catalyzed ON-OFF switchable hydrogenation using a molecular shuttle based on a [2]rotaxane with a phosphine ligand. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2022, 61(15): [9] Li, Faju, Long, Linhong, He, YanMei, Li, Zeyu, Chen, Hui, Fan, QingHua. Manganese-Catalyzed Asymmetric Formal Hydroamination of Allylic Alcohols: A Remarkable Macrocyclic Ligand Effect. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2022, 61(26): http://dx.doi.org/10.1002/anie.202202972.
[10] Zhang, ShuXin, Xu, Cong, Yi, Niannian, Li, Shan, He, YanMei, Feng, Yu, Fan, QingHua. Ruthenium-Catalyzed Enantioselective Hydrogenation of 9-Phenanthrols. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2022, 61(34): http://dx.doi.org/10.1002/anie.202205739.
[11] Li, Chenghao, Fan, QingHua. Ruthenium-catalyzed enantioselective hydrogenation of quinoxalinones and quinazolinones. ORGANIC CHEMISTRY FRONTIERS[J]. 2022, 9(2): 400-406, http://dx.doi.org/10.1039/d1qo01598b.
[12] Luo, Zhenli, Pan, Yixiao, Yao, Zhen, Yang, Ji, Zhang, Xin, Liu, Xintong, Xu, Lijin, Fan, QingHua. BF3 center dot Et2O as a metal-free catalyst for direct reductive amination of aldehydes with amines using formic acid as a reductant. GREEN CHEMISTRY[J]. 2021, 23(14): 5205-5211, http://dx.doi.org/10.1039/d1gc01468d.
[13] Xu, Cong, Feng, Yu, Wang, LiRen, Ma, WenPeng, He, YanMei, Fan, QingHua. Development of Quinoline-Derived Chiral Diaminocarbene Ligands and Their Transition Metal Complexes: Synthesis, Structural Characterization, and Catalytic Properties. ORGANOMETALLICS[J]. 2020, 39(10): 1945-1960, https://www.webofscience.com/wos/woscc/full-record/WOS:000537685700030.
[14] 张树辛, 冯宇, 范青华. 过渡金属催化的不对称氢化反应的国内研究进展. 高等学校化学学报[J]. 2020, 41(10): 2107-2136, http://lib.cqvip.com/Qikan/Article/Detail?id=7102912790.
[15] Luo, Yier, Ouyang, Guanghui, Tang, Yuping, He, YanMei, Fan, QingHua. Diaza-Crown Ether-Bridged Chiral Diphosphoramidite Ligands: Synthesis and Applications in Asymmetric Catalysis. JOURNAL OF ORGANIC CHEMISTRY[J]. 2020, 85(12): 8176-8184, https://www.webofscience.com/wos/woscc/full-record/WOS:000543667400050.
[16] Li, Chenghao, Pan, Yixiao, Feng, Yu, He, YanMei, Liu, Youran, Fan, QingHua. Asymmetric Ruthenium-Catalyzed Hydrogenation of Terpyridine-Type N-Heteroarenes: Direct Access to Chiral Tridentate Nitrogen Ligands. ORGANIC LETTERS[J]. 2020, 22(16): 6452-6457, http://dx.doi.org/10.1021/acs.orglett.0c02268.
[17] Chen, Ya, Pan, Yixiao, He, YanMei, Fan, QingHua. Consecutive Intermolecular Reductive Amination/Asymmetric Hydrogenation: Facile Access to Sterically Tunable Chiral Vicinal Diamines and N-Heterocyclic Carbenes. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(47): 16831-16834, https://www.webofscience.com/wos/woscc/full-record/WOS:000495739600018.
[18] Chen, Ya, He, YanMei, Zhang, Shanshan, Miao, Tingting, Fan, QingHua. Rapid Construction of Structurally Diverse Quinolizidines, Indolizidines, and Their Analogues via Ruthenium-Catalyzed Asymmetric Cascade Hydrogenation/Reductive Amination. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(12): 3809-3813, https://www.webofscience.com/wos/woscc/full-record/WOS:000462680700020.
[19] Zhang, Shanshan, Chen, Fei, He, YanMei, Fan, QingHua. Asymmetric Hydrogenation of Dibenzoc,eazepine Derivatives with Chiral Cationic Ruthenium Diamine Catalysts. ORGANIC LETTERS[J]. 2019, 21(14): 5538-5541, https://www.webofscience.com/wos/woscc/full-record/WOS:000476957200035.
[20] Xu, Cong, Feng, Yu, Li, Faju, Han, Jiahong, He, YanMei, Fan, QingHua. A Synthetic Route to Chiral Benzo-Fused N-Heterocycles via Sequential Intramolecular Hydroamination and Asymmetric Hydrogenation of Anilino-Alkynes. ORGANOMETALLICS[J]. 2019, 38(20): 3979-3990, [21] Liu, Youran, Chen, Fei, He, YanMei, Li, Chenghao, Fan, QingHua. Enantioselective synthesis of tunable chiral pyridine-aminophosphine ligands and their applications in asymmetric hydrogenation. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2019, 17(20): 5099-5105, https://www.webofscience.com/wos/woscc/full-record/WOS:000468790100019.
[22] Bin Li, Cong Xu, YanMei He, GuoJun Deng, QingHua Fan. Asymmetric Hydrogenation of Bis(quinolin-2-yl)methanes:A Direct Access to Chiral 1,3-Diamines. 中国化学:英文版[J]. 2018, 36(12): 1169-1173, http://lib.cqvip.com/Qikan/Article/Detail?id=6100154722.
[23] 唐雨平, 何艳梅, 冯宇, 范青华. 基于大环主体化合物的不对称超分子催化. 化学进展[J]. 2018, 30(5): 476-490, http://lib.cqvip.com/Qikan/Article/Detail?id=675387079.
[24] Miao, Tingting, Ma, Baode, Ding, Ziyuan, Liu, Youran, He, YanMei, Fan, QingHua. Chemoselective and Enantioselective Hydrogenation of 2,4-Diaryl-3H-benzobazepines Catalyzed by Dendritic Phosphinooxazoline Iridium Complexes. ASIAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2017, 6(9): 1219-1221, https://www.webofscience.com/wos/woscc/full-record/WOS:000410778400013.
[25] Miao, Tingting, Tian, ZiYou, He, YanMei, Chen, Fei, Chen, Ya, Yu, ZhiXiang, Fan, QingHua. Asymmetric Hydrogenation of In Situ Generated Isochromenylium Intermediates by Copper/Ruthenium Tandem Catalysis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2017, 56(15): 4135-4139, [26] Yang, Zhusheng, Chen, Fei, Zhang, Shuxin, He, Yanmei, Yang, Nianfa, Fan, QingHua. Ruthenium-Catalyzed Enantioselective Hydrogenation of Phenanthridine Derivatives. ORGANIC LETTERS[J]. 2017, 19(6): 1458-1461, https://www.webofscience.com/wos/woscc/full-record/WOS:000397077400049.
[27] Yang, Zhusheng, Ding, Ziyuan, Chen, Fei, He, YanMei, Yang, Nianfa, Fan, QingHua. Asymmetric Hydrogenation of Cyclic Imines of Benzoazepines and Benzodiazepines with Chiral, Cationic Ruthenium-Diamine Catalysts. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2017, 2017(14): 1973-1977, https://www.webofscience.com/wos/woscc/full-record/WOS:000399700300024.
[28] Luo, YiEr, He, YanMei, Fan, QingHua. Asymmetric Hydrogenation of Quinoline Derivatives Catalyzed by Cationic Transition Metal Complexes of Chiral Diamine Ligands: Scope, Mechanism and Catalyst Recycling. CHEMICAL RECORD[J]. 2016, 16(6): 2697-2711, http://ir.iccas.ac.cn/handle/121111/36522.
[29] Ma, Wenpeng, Zhang, Jianwei, Xu, Cong, Chen, Fei, He, YanMei, Fan, QingHua. Highly Enantioselective Direct Synthesis of Endocyclic Vicinal Diamines through Chiral Ru(diamine)-Catalyzed Hydrogenation of 2,2-Bisquinoline Derivatives. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2016, 55(41): 12891-12894, https://www.webofscience.com/wos/woscc/full-record/WOS:000385713200059.
[30] Wang, Tianli, Chen, Ya, Ouyang, Guanghui, He, YanMei, Li, Zhiyan, Fan, QingHua. Solvent-Regulated Asymmetric Hydrogenation of Quinoline Derivatives in Oligo(Ethylene Glycol)s through Host-Guest Interactions. CHEMISTRY-AN ASIAN JOURNAL[J]. 2016, 11(19): 2773-2777, http://ir.iccas.ac.cn/handle/121111/35126.
[31] Qing-Hua Fan. Highly enantioselective synthesis of indolines via asymmetric hydrogenation at ambient temperature and pressure with cationic ruthenium diamine catalysts. Angew. Chem. Int. Ed.. 2016, [32] Ouyang, GuangHui, He, YanMei, Li, Yong, Xiang, JunFeng, Fan, QingHua. Cation-Triggered Switchable Asymmetric Catalysis with Chiral Aza-CrownPhos. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2015, 54(14): 4334-4337, http://ir.iccas.ac.cn/handle/121111/28482.
[33] Chen Fei. Asymmetric Ruthenium-Catalyzed Hydrogenation of 2,6-disubstituted 1,5-Naphthyridines: Easy Access to Chiral 1,5-Diaza-cis-Decalins. Angew. Chem. Int. Ed.. 2015, [34] Zhang, Jianwei, Chen, Fei, He, YanMei, Fan, QingHua. Asymmetric Ruthenium-Catalyzed Hydrogenation of 2,6-Disubstituted 1,5-Naphthyridines: Access to Chiral 1,5-Diaza-cis-Decalins. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2015, 54(15): 4622-4625, http://dx.doi.org/10.1002/anie.201411105.
[35] He, YanMei, Feng, Yu, Fan, QingHua. Asymmetric Hydrogenation in the Core of Dendrimers. ACCOUNTS OF CHEMICAL RESEARCH[J]. 2014, 47(10): 2894-2906, https://www.webofscience.com/wos/woscc/full-record/WOS:000343640600004.
[36] Wang, Tianli, Chen, Fei, Qin, Jie, He, YanMei, Fan, QingHua. Asymmetric Ruthenium-Catalyzed Hydrogenation of 2-and 2,9-Substituted 1,10-Phenanthrolines. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2013, 52(28): 7172-7176, http://dx.doi.org/10.1002/anie.201301830.
[37] Ding, ZiYuan, Chen, Fei, Qin, Jie, He, YanMei, Fan, QingHua. Asymmetric Hydrogenation of 2,4-Disubstituted 1,5-Benzodiazepines Using Cationic Ruthenium Diamine Catalysts: An Unusual Achiral Counteranion Induced Reversal of Enantioselectivity. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2012, 51(23): 5706-5710, https://www.webofscience.com/wos/woscc/full-record/WOS:000304814000035.
[38] Wang, Tianli, Zhuo, LianGang, Li, Zhiwei, Chen, Fei, Ding, Ziyuan, He, Yanmei, Fan, QingHua, Xiang, Junfeng, Yu, ZhiXiang, Chan, Albert S C. Highly Enantioselective Hydrogenation of Quinolines Using Phosphine-Free Chiral Cationic Ruthenium Catalysts: Scope, Mechanism, and Origin of Enantioselectivity. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2011, 133(25): 9878-9891, http://dx.doi.org/10.1021/ja2023042.
代表性专著(章节):
(1) 丁奎岭,范青华 主编,《不对称催化新概念与新方法》,化学工业出版社,2008年。
(2) 李月明,范青华,陈新滋 主编,《不对称有机反应》,化学工业出版社,2004年。
(3) 李月明,范青华,陈新滋 著,《不对称有机反应 —— 催化剂的回收与再利用》,化学工业出版社,2003年。
(4) Qing-Hua Fan, Guo-Jun Deng, Yu Feng, Yan-Mei He, “Enantioselective Catalysis Using Dendrimer Supports” In Handbook of 
     Asymmetric Heterogeneous Catalysis, Eds, Kuiling Ding and Yasuhiro Uozumi, Wiley-VCH: Weinheim, 2008, p131-180.