1986-09--1992-07   美国弗吉尼亚大学   博士
1981-09--1986-07   中国科技大学   学士

   

2004-06~现在, 国家纳米科学中心, 副主任、主任
1995-07~2004-05,中国科学院化学研究所, 研究员
1994-02~1995-05,华中师范大学, 教授
1992-07~1993-12,美国亚利桑那大学, 博士后
1986-09~1992-07,美国弗吉尼亚大学, 博士
1981-09~1986-07,中国科技大学, 学士

纳米科学导论
生物纳米材料
入学教育与交流
纳米生物材料与技术
纳米科学概论
纳米与生物技术前沿讲座
纳米科技前沿讲座
纳米生物医学系列讲座

   

（1） 教育部科技一等奖, 一等奖, 部委级, 2003
（2） 中国化学会青年化学奖, , 部委级, 1988

   

（1） Stable Peptide Binding Achieved through an Intrinsically Ordered Spiral Conformation with Ten-Glycine Spacing: Insights from MD Simulation, J. Phys. Chem. B, 2025, 第 6 作者  通讯作者
（2） SpatiallyCoordinatedDelivery of siRNA and Peptide AntagonistbyUsingQuantumDots for SynergeticCancer Therapy, ChemEurJ, 2025, 第 6 作者  通讯作者
（3） Nanoparticles for the treatment of spinal cord injury, Nanoparticles for the treatment of spinal cord injury, NEURAL REGENERATION RESEARCH, 2025, 第 8 作者
（4） Development of a CXCR4 antagonistic peptide, P12, to suppress pancreatic cancer progress via enhancing T cell responses and sensitizing cells to gemcitabine, RSC Medicinal Chemistry, 2025, 第 1 作者
（5） Submolecular Resolution Imaging of Amyloid Aggregation: An STM Approach to Decipher Missense Mutation Effects in ��-Synuclein, NANO LETTERS, 2025, 第 8 作者
（6） Submolecular Resolution of ��-Sheet Plasticity: Decoding Mutations and PTMs in Protein Aggregation Disorders, ACS CENTRAL SCIENCE, 2025, 第 4 作者
（7） Targeted degradation of Pin1 by an antagonistic peptide enhances gemcitabine therapy in pancreatic cancer, RSC Medicinal Chemistry, 2025, 第 1 作者  通讯作者
（8） Comprehensive and Facile Strategy for Enhanced Visualization of Sialylated RNA via Dual Bioorthogonal Labeling, ACS Chem. Biol., 2025, 第 4 作者  通讯作者
（9） T lymphocyte-derived immunogenic hybrid nanovesicles for immunosuppression reversion and boosted photothermal immunotherapy, NANO TODAY, 2024, 第 8 作者  通讯作者
（10） Structural evolution of the conformational ensembles in peptide fibrillar aggregates, MATERIALS TODAY PHYSICS, 2024, 第 9 作者
（11） Principles of glycan-nucleotide interactions revealed by binding affinities between glycans and single-stranded DNA molecules, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2024, 第 7 作者  通讯作者
（12） Principles of glycan-nucleotide interactions revealed by binding affinities between glycans and single-stranded DNA molecules, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2024, 第 7 作者  通讯作者
（13） Principles of glycan-nucleotide interactions revealed by binding affinities between glycans and single-stranded DNA molecules, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2024, 第 7 作者  通讯作者
（14） Dual-functional extracellular vesicles enable synergistic treatment via m 6 A reader YTHDF1-targeting epigenetic regulation and chemotherapy, NANO RESEARCH, 2023, 第 4 作者  通讯作者
（15） Dual-functional extracellular vesicles enable synergistic treatment via m6A reader YTHDF1-targeting epigenetic regulation and chemotherapy, Nano Resaerch, 2023, 第 4 作者  通讯作者
（16） A Nucleus-Targeting WT1 Antagonistic Peptide Encapsulated in Polymeric Nanomicelles Combats Refractory Chronic Myeloid Leukemia, PHARMACEUTICS, 2023, 第 8 作者  通讯作者
（17） Peptide-based coacervates in therapeutic applications, FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2023, 第 3 作者  通讯作者
（18） Prominent enhancement of peptide-mediated targeting efficiency for human hepatocellular carcinomas with composition-engineered protein corona on gold nanoparticles, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2023, 第 8 作者  通讯作者
（19） Formulated nano-liposomes for reversal of cisplatin resistance in NSCLC with nucleus-targeting peptide, Nano Research, 2023, 第 7 作者  通讯作者
（20） Principles of Amino-Acid-Ribonucleotide Interaction Revealed by Binding Affinities between Homogeneous Oligopeptides and Single-stranded RNA Molecules, Nano Research, 2023, 第 6 作者  通讯作者
（21） Extracellular Vesicles as Delivery Vehicles for Therapeutic Nucleic Acids in Cancer Gene Therapy: Progress and Challenges, PHARMACEUTICS, 2022, 第 2 作者
（22） Principles of Amino-Acid-Nucleotide Interactions Revealed by Binding Affinities between Homogeneous Oligopeptides and Single-Stranded DNA Molecules, CHEMBIOCHEM, 2022, 第 12 作者  通讯作者
（23） Heterochirality-Mediated Cross-Strand Nested Hydrophobic Interaction Effects Manifested in Surface-Bound Peptide Assembly Structures, JOURNAL OF PHYSICAL CHEMISTRY B, 2022, 第 8 作者
（24） Machine Learning-Assisted Dual-Marker Detection in Serum Small Extracellular Vesicles for the Diagnosis and Prognosis Prediction of Non-Small Cell Lung Cancer, NANOMATERIALS, 2022, 第 8 作者
（25） A nucleus-targeting peptide antagonist towards EZH2 displays therapeutic efficacy for lung cancer, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2022, 第 8 作者  通讯作者
（26） A nucleus-targeting peptide antagonist towards EZH2 displays therapeutic efficacy for lung cancer, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2022, 第 8 作者  通讯作者
（27） Peptide-Enabled Targeted Delivery Systems for Therapeutic Applications, FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2021, 第 4 作者  通讯作者
（28） Enhancement of gold-nanocluster-mediated chemotherapeutic efficiency of cisplatin in lung cancer, JOURNAL OF MATERIALS CHEMISTRY B, 2021, 第 9 作者  通讯作者
（29） Anti-fouling peptide functionalization of ultraflexible neural probes for long-term neural activity recordings in the brain, BIOSENSORS & BIOELECTRONICS, 2021, 第 8 作者  通讯作者
（30） Peptide-directed delivery of drug-loaded nanocarriers targeting CD36 overexpressing cells, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2021, 第 4 作者  通讯作者
（31） Quantitative Nanomechanical Analysis of Small Extracellular Vesicles for Tumor Malignancy Indication, ADVANCED SCIENCE, 2021, 第 5 作者  通讯作者
（32） Peptoid Nanosheet-Based Sensing System for the Diagnosis and Surveillance of Amnestic Mild Cognitive Impairment and Alzheimer's Disease, ACS CHEMICAL NEUROSCIENCE, 2021, 第 7 作者
（33） Enhanced lymphatic delivery of nanomicelles encapsulating CXCR4-recognizing peptide and doxorubicin for the treatment of breast cancer, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021, 第 8 作者  通讯作者
（34） Molecular recognition of human islet amyloid polypeptide assembly by selective oligomerization of thioflavin T, SCIENCE ADVANCES, 2020, 第 12 作者
（35） Position-coded multivalent peptide-peptide interactions revealed by tryptophan-scanning mutagenesis, JOURNAL OF PEPTIDE SCIENCE, 2020, 第 6 作者  通讯作者
（36） Persistent Regulation of Tumor Hypoxia Microenvironment via a Bioinspired Pt���Based Oxygen Nanogenerator for Multimodal Imaging���Guided Synergistic Phototherapy, ADVANCED SCIENCE, 2020, 第 10 作者
（37） Peptide-enabled receptor-binding-quantum dots for enhanced detection and migration inhibition of cancer cells, JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2020, 第 8 作者  通讯作者
（38） Synthetic CXCR4 Antagonistic Peptide Assembling with Nanoscaled Micelles Combat Acute Myeloid Leukemia, SMALL, 2020, 第 13 作者  通讯作者
（39） Peptide conformation and oligomerization characteristics of surface-mediated assemblies revealed by molecular dynamics simulations and scanning tunneling microscopy, RSC ADVANCES, 2019, 第 9 作者  通讯作者
（40） Improved tumor targeting and penetration by a dual-functional poly(amidoamine) dendrimer for the therapy of triple-negative breast cancer, JOURNAL OF MATERIALS CHEMISTRY B, 2019, 第 5 作者  通讯作者
（41） Identifying Terminal Assembly Propensity of Amyloidal Peptides by Scanning Tunneling Microscopy, CHEMPHYSCHEM, 2019, 第 9 作者  通讯作者
（42） Evaluation of serum extracellular vesicles as noninvasive diagnostic markers of glioma, THERANOSTICS, 2019, 第 7 作者
（43） Principles of Inter-Amino-Acid Recognition Revealedby Binding Energies between Homogeneous Oligopeptides, ACS CENTRAL SCIENCE, 2019, 第 21 作者  通讯作者
（44） Peptide-Polyphenol (KLVFF/EGCG) Binary Modulators for Inhibiting Aggregation and Neurotoxicity of Amyloid-beta Peptide, ACS OMEGA, 2019, 第 9 作者  通讯作者
（45） On-Surface Crystallization Behaviors of H-Bond Donor-Acceptor Complexes at Liquid/Solid Interfaces, LANGMUIR, 2019, 第 11 作者  通讯作者
（46） Steric Dependence of Chirality Effect in Surface-Mediated Peptide Assemblies Identified with Scanning Tunneling Microscopy, NANO LETTERS, 2019, 第 5 作者  通讯作者
（47） Modulation of beta-amyloid aggregation by graphene quantum dots, ROYAL SOCIETY OPEN SCIENCE, 2019, 第 5 作者  通讯作者
（48） Diagnosis of Invasive Nonfunctional Pituitary Adenomas by Serum Extracellular Vesicles, ANALYTICAL CHEMISTRY, 2019, 第 5 作者
（49） Nrp-1 receptor targeting peptide-functionalized TPGS micellar nanosystems to deliver 10-hydroxycampothecin for enhanced cancer chemotherapy, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2018, 第 6 作者
（50） 二维过渡金属硫化物纳米复合材料的模拟酶特性及应用, Two-dimentional Transition-metal Dichalcogenide Nanocomposites as Novel Enzyme Mimics: An Overview, 生物化学与生物物理进展, 2018, 第 3 作者
（51） Unraveling the roles of cd44/cd24 and aldh1 as cancer stem cell markers in tumorigenesis and metastasis (vol 7, 2017), SCIENTIFIC REPORTS, 2018, 第 5 作者  通讯作者
（52） GO-AgCl/Ag nanocomposites with enhanced visible light-driven catalytic properties for antibacterial and biofilm-disrupting applications, COLLOIDS AND SURFACES B-BIOINTERFACES, 2018, 第 5 作者  通讯作者
（53） Site-specific determination of TTR-related functional peptides by using scanning tunneling microscopy, NANO RESEARCH, 2018, 第 9 作者  通讯作者
（54） Probing Molecular Basis for Constructing Interface Bionanostructures, TOPICS IN CATALYSIS, 2018, 第 5 作者  通讯作者
（55） Peptide-functionalized carbon dots for sensitive and selective Ca2+ detection, SENSORSANDACTUATORSBCHEMICAL, 2018, 第 7 作者  通讯作者
（56） Peptide-Functionalized Nanomaterials for the Efficient Isolation of HER2-Positive Circulating Tumor Cells, ACS APPLIED MATERIALS & INTERFACES, 2017, 第 10 作者  通讯作者
（57） Unraveling the roles of cd44/cd24 and aldh1 as cancer stem cell markers in tumorigenesis and metastasis, SCIENTIFIC REPORTS, 2017, 第 5 作者  通讯作者
（58） Molybdenum Disulfide Nanoparticles as Multifunctional Inhibitors against Alzheimer's Disease, ACS APPLIED MATERIALS & INTERFACES, 2017, 第 7 作者  通讯作者
（59） Antibody-Mimetic Peptoid Nanosheet for Label-Free Serum-Based Diagnosis of Alzheimer's Disease, ADVANCED MATERIALS, 2017, 第 8 作者  通讯作者
（60） MoS2-Pt3Au1 Nanocomposites with Enhanced Peroxidase-Like Activities for Selective Colorimetric Detection of Phenol, MoS2-Pt3Au1 Nanocomposites with Enhanced Peroxidase-Like Activities for Selective Colorimetric Detection of Phenol, 中国化学：英文版, 2017, 第 8 作者
（61） Targeting the CXCR4/CXCL12 axis with the peptide antagonist E5 to inhibit breast tumor progression, Targeting the CXCR4/CXCL12 axis with the peptide antagonist E5 to inhibit breast tumor progression, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2017, 第 7 作者  通讯作者
（62） Fluorine Functionalized Graphene Quantum Dots as Inhibitor against hIAPP Amyloid Aggregation, ACS CHEMICAL NEUROSCIENCE, 2017, 第 4 作者
（63） Versatile graphene-based photothermal nanocomposites for effectively capturing and killing bacteria, and for destroying bacterial biofilms, JOURNAL OF MATERIALS CHEMISTRY B, 2017, 第 4 作者  通讯作者
（64） Studies on Composition and Sequence Effects in Surface-Mediated Octapeptide Assemblies by Using Scanning Tunneling Microscopy, JOURNAL OF PHYSICAL CHEMISTRY C, 2017, 第 8 作者  通讯作者
（65） Photo-regulation of 2D supramolecular self-assembly: On-surface photochemistry studied by STM, CHINESE CHEMICAL LETTERS, 2017, 第 4 作者  通讯作者
（66） Stabilization effect of amino acid side chains in peptide assemblies on graphite studied by scanning tunneling microscopy, CHEMPHYSCHEM, 2017, 第 5 作者  通讯作者
（67） Peptide-binding induced inhibition of chemokine cxcl12, RSC ADVANCES, 2017, 第 13 作者  通讯作者
（68） Allosteric Modulation of Human Serum Albumin Induced by Peptide Ligand, CHINESE JOURNAL OF CHEMISTRY, 2017, 第 8 作者  通讯作者
（69） Allosteric Modulation of Human Serum Albumin Induced by Peptide Ligand, Allosteric Modulation of Human Serum Albumin Induced by Peptide Ligand, 中国化学：英文版, 2017, 第 8 作者
（70） Enhanced oxidase/peroxidase-like activities of aptamer conjugated MoS 2 /PtCu nanocomposites and their biosensing application, RSC ADVANCES, 2016, 第 8 作者
（71） Nano-cage-mediated refolding of insulin by PEG-PE micelle, BIOMATERIALS, 2016, 第 7 作者  通讯作者
（72） Host-guest supramolecular chemistry at solid-liquid interface: An important strategy for preparing two-dimensional functional nanostructures, SCIENCE CHINA Chemistry, 2014, 第 3 作者
（73） Bridging mesoscopic blend structure and property to macroscopic device performance via in situ optoelectronic characterization, JOURNAL OF MATERIALS CHEMISTRY, 2012, 第 8 作者
（74） Sequential assembly of metal-free phthalocyanine on few-layer epitaxial graphene mediated by thickness-dependent surface potential, NANO RESEARCH, 2012, 第 9 作者
（75） Carbon Nanotubes Enhance Cytotoxicity Mediated by Human Lymphocytes In Vitro, PLOS ONE, 2011, 第 9 作者
（76） Construction of tunable supramolecular networks studied by scanning tunneling microscopy, SCIENCE CHINA Chemistry, 2010, 第 2 作者  通讯作者
（77） NiO Thin Film Fabricated by Electrophoretic Deposition and Formaldehyde Gas Sensing Property Thereof, JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2009, 第 4 作者
（78） Oxygen Desorption from Single-Walled Carbon Nanotubes by Camera Flash, JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2009, 第 7 作者
（79） On the topography multiplicity of non-planar titanyl (IV) phthalocyanine molecules and the STM imaging mechanism, SURFACE SCIENCE, 2008, 第 4 作者  通讯作者
（80） Individual water-filled single-walled carbon nanotubes as hydroelectric power converters, ADVANCED MATERIALS, 2008, 第 7 作者
（81） Carbon nanotubes conjugated to tumor lysate protein enhance the efficacy of an antitumor immunotherapy, SMALL, 2008, 第 5 作者
（82） Highly dense and perfectly aligned single-walled carbon nanotubes fabricated by diamond wire drawing dies, NANO LETTERS, 2008, 第 15 作者
（83） Interactions between blood proteins and multiwalled carbon nanotubes in aqueous solution, NEW CARBON MATERIALS, 2007, 第 7 作者
（84） 铁氧化物中电子隧道现象的扫描隧道显微术研究, EECTRON TUNNELING PHENOMENA IN IRON OXIDES STUDIED WITH SCANNING TUNNELING MICROSCOPY AT 4. 2K, 物理学报, 1996, 第 1 作者
（85） STM/STS实验中单电子隧道现象的观测, EFFECTS OF SINGLE ELECTRON TUNNELING IN STM/STS STUDIES USING Fe TIPS, 物理学报, 1996, 第 1 作者
（86） Development of a CXCR4 antagonistic peptide, P12, to suppress pancreatic cancer progress via enhancing T cell responses and sensitizing cells to gemcitabine, RSC MEDICINAL CHEMISTRY, 第 13 作者

（ 1 ） 扫描探针显微术应用进展, 无, 化学工业出版社, 2007-07, 第 2 作者
（ 2 ） 施普林格纳米技术手册, Springer handbook of nano-technology, 科学出版社, 2009-01, 第 2 作者

   

（ 1 ） 功能纳米系统的精准构筑原理与测量, 负责人, 中国科学院计划, 2020-01--2024-12
（ 2 ） 多肽组装趋势的分子水平研究, 负责人, 国家任务, 2017-01--2020-12
（ 3 ） 变革性纳米产业制造技术聚焦, 负责人, 中国科学院计划, 2013-07--2017-12
（ 4 ） 纳米测量技术标准的基础研究, 负责人, 国家任务, 2011-01--2015-01
（ 5 ） 与重大慢性疾病诊治相关的纳米技术基础研究, 负责人, 中国科学院计划, 2009-07--2013-12
（ 6 ） 强电场条件下表面纳米尺度的电润湿性质研究, 负责人, 国家任务, 2009-07--2011-12
（ 7 ） 自组装功能分子纳米结构研究, 负责人, 国家任务, 2009-02--2012-12