071009-细胞生物学
071010-生物化学与分子生物学

纳米酶的开发应用及机制研究
靶向肿瘤药物载体及机制研究
肿瘤靶分子微环境调控网络及治疗研究

   

（1） 何梁何利生命科学进步奖, 一等奖, 其他, 2021
（2） 全国三八红旗手标兵, , 国家级, 2019
（3） 谈家桢生命科学成就奖, 国家级, 2018
（4） 全国创新争先奖, , 国家级, 2017
（5） 巾帼文明岗, , 国家级, 2017
（6） 全国三八红旗手, , 国家级, 2015
（7） Atlas国际奖, 特等奖, 其他, 2015
（8） 北京市科学技术奖, 一等奖, 省级, 2014
（9） 国家自然科学奖, 二等奖, 国家级, 2012
（10） 中国科学院第四届十大杰出妇女, , 院级, 2012
（11） 中国科学院优秀研究生指导教师奖, , 院级, 2011
（12） 北京市科学技术奖, 一等奖, 省级, 2011
（13） 中国科学院先进工作者, , 院级, 2010
（14） 全国优秀科技工作者, , 国家级, 2010
（15） 北京市科学技术奖, 一等奖, 市地级, 2009
（16） 国家政府特殊津贴, , 国家级, 2007

   

[1] Jiang, Bing, Chen, Xuehui, Wang, Shenghui, Wang, Shuyu, Ma, Saiyu, Lu, Yu, Ma, Long, Liang, Qian, Xiao, Haihua, Zhang, Lirong, Yan, Xiyun, Fan, Kelong. Structure-Guided Design of Ferritin-Platinum Prodrugs for Targeted Therapy of Esophageal Squamous Cell Carcinoma. ACS NANO[J]. 2024, 第 11 作者  通讯作者  18(17): 11217-11233, http://dx.doi.org/10.1021/acsnano.4c00212.
[2] Fan, Huizhen, Zheng, Jiajia, Xie, Jiaying, Liu, Juewen, Gao, Xingfa, Yan, Xiyun, Fan, Kelong, Gao, Lizeng. Surface Ligand Engineering Ruthenium Nanozyme Superior to Horseradish Peroxidase for Enhanced Immunoassay. ADVANCED MATERIALS[J]. 2024, 第 6 作者36(null): 2300387, 
[3] Yuan, Ye, Chen, Lei, Song, Kexu, Cheng, Miaomiao, Fang, Ling, Kong, Lingfei, Yu, Lanlan, Wang, Ruonan, Fu, Zhendong, Sun, Minmin, Wang, Qian, Cui, Chengjun, Wang, Haojue, He, Jiuyang, Wang, Xiaonan, Liu, Yuan, Jiang, Bing, Jiang, Jing, Wang, Chenxuan, Yan, Xiyun, Zhang, Xinzheng, Gao, Lizeng. Stable peptide-assembled nanozyme mimicking dual antifungal actions. NATURE COMMUNICATIONS[J]. 2024, 第 20 作者15(1): http://dx.doi.org/10.1038/s41467-024-50094-6.
[4] Fan, Huizhen, Zhang, Ruofei, Fan, Kelong, Gao, Lizeng, Yan, Xiyun. Exploring the Specificity of Nanozymes. ACS NANO. 2024, 第 5 作者  通讯作者  18(4): 2533-2540, http://dx.doi.org/10.1021/acsnano.3c07680.
[5] Liao, Xingrui, Wang, Jiamin, Guo, Bing, Bai, Mengfan, Zhang, Yao, Yu, Gege, Wang, Peng, Wei, Juan, Wang, Jianlong, Yan, Xiyun, Fan, Kelong, Wang, Yanru. Enhancing Nanobody Immunoassays through Ferritin Fusion: Construction of a Salmonella -Specific Fenobody for Improved Avidity and Sensitivity. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2024, 第 10 作者72(26): 14967-14974, http://dx.doi.org/10.1021/acs.jafc.4c03606.
[6] Gao, Lizeng, Wei, Hui, Dong, Shaojun, Yan, Xiyun. The Nanozymes. ADVANCED MATERIALS. 2024, 第 4 作者  通讯作者  36(10): http://dx.doi.org/10.1002/adma.202305249.
[7] 蒋青, 徐标, 龚旺, 王鹏, 刘吉梓, 周游, 孙璇, 鲍雪, 徐运, 张冰, 吕晗, 段红霞, 王振常, 阎锡蕴, 顾宁. 血管-神经-淋巴网络稳态与失衡对健康评估的价值. 中华医学杂志[J]. 2024, 第 14 作者104(15): 1323-1330, http://lib.cqvip.com/Qikan/Article/Detail?id=00523JLXM7CO1J1V9Y.
[8] Ma, Long, Zheng, JiaJia, Zhou, Ning, Zhang, Ruofei, Fang, Long, Yang, Yili, Gao, Xingfa, Chen, Chunying, Yan, Xiyun, Fan, Kelong. A natural biogenic nanozyme for scavenging superoxide radicals. NATURE COMMUNICATIONS[J]. 2024, 第 9 作者  通讯作者  15(1): http://dx.doi.org/10.1038/s41467-023-44463-w.
[9] Jianwei Ding, Wendi Luo, Ting Wu, Shuangfei Cai, ZiAn Pan, Haolin Li, Bin Tu, Qiaojun Fang, Xiyun Yan, Rong Yang. Atomic-thick porous Pd nanosheets with antioxidant enzyme-like activities and photothermal properties for potential Alzheimer’s disease treatment. NANO TODAY[J]. 2024, 第 9 作者  通讯作者  54(null): http://dx.doi.org/10.1016/j.nantod.2023.102121.
[10] Jiang, Wei, Li, Qing, Zhang, Ruofei, Li, Jianru, Lin, Qianyu, Li, Jingyun, Zhou, Xinyao, Yan, Xiyun, Fan, Kelong. Chiral metal-organic frameworks incorporating nanozymes as neuroinflammation inhibitors for managing Parkinson's disease. NATURE COMMUNICATIONS[J]. 2023, 第 8 作者  通讯作者  14(1): http://dx.doi.org/10.1038/s41467-023-43870-3.
[11] Wang, Daji, Wang, Jie, Liu, Dan, He, Jiuyang, Wang, Meiying, Huang, Haibing, Nie, Guohui, Ding, Hui, Yan, Xiyun. Rapid and sensitive detection of Epstein-Barr virus antibodies in nasopharyngeal carcinoma by chemiluminescence strips based on iron-porphyrin single atom nanozyme. NANO RESEARCH. 2023, 第 9 作者  通讯作者  http://dx.doi.org/10.1007/s12274-023-5915-4.
[12] Fang, Long, Zhang, Ruofei, Shi, Lin, Xie, Jiaying, Ma, Long, Yang, Yili, Yan, Xiyun, Fan, Kelong. Protein-Nanocaged Selenium Induces t(8;21) Leukemia Cell Differentiation via Epigenetic Regulation. ADVANCED SCIENCE[J]. 2023, 第 7 作者  通讯作者  10(35): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10724402/.
[13] Li, Yucong, Zhang, Ruofei, Yan, Xiyun, Fan, Kelong. Machine learning facilitating the rational design of nanozymes. JOURNAL OF MATERIALS CHEMISTRY B. 2023, 第 3 作者  通讯作者  11(28): 6466-6477, http://dx.doi.org/10.1039/d3tb00842h.
[14] 范克龙, 高利增, 魏辉, 江冰, 王大吉, 张若飞, 贺久洋, 孟祥芹, 王卓然, 樊慧真, 温涛, 段德民, 陈雷, 姜伟, 芦宇, 蒋冰, 魏咏华, 李唯, 袁野, 董海姣, 张鹭, 洪超仪, 张紫霞, 程苗苗, 耿欣, 侯桐阳, 侯亚欣, 李建茹, 汤国恒, 赵越, 赵菡卿, 张帅, 谢佳颖, 周子君, 任劲松, 黄兴禄, 高兴发, 梁敏敏, 张宇, 许海燕, 曲晓刚, 阎锡蕴. 纳米酶. 化学进展[J]. 2023, 第 42 作者35(1): 1-87, http://lib.cqvip.com/Qikan/Article/Detail?id=7109514304.
[15] Cheng, Miaomiao, Xin, Qi, Ma, Saiyu, Ge, Mengyue, Wang, Feng, Yan, Xiyun, Jiang, Bing. Advances in the Theranostics of Oesophageal Squamous Carcinoma. ADVANCED THERAPEUTICS. 2023, 第 6 作者6(7): http://dx.doi.org/10.1002/adtp.202200251.
[16] Wang, Zhuoran, Zhao, Yue, Hou, Yaxin, Tang, Guoheng, Zhang, Ruofei, Yang, Yili, Yan, Xiyun, Fan, Kelong. A Thrombin-Activated Peptide-Templated Nanozyme for Remedying Ischemic Stroke via Thrombolytic and Neuroprotective Actions. ADVANCED MATERIALS. 2023, 第 7 作者  通讯作者  http://dx.doi.org/10.1002/adma.202210144.
[17] Li, Jianru, Zhang, Zixia, Zhang, Baoli, Yan, Xiyun, Fan, Kelong. Transferrin receptor 1 targeted nanomedicine for brain tumor therapy. BIOMATERIALS SCIENCE. 2023, 第 4 作者  通讯作者  11(10): http://dx.doi.org/10.1039/d2bm02152h.
[18] Zhu, Mingsheng, Zhuang, Jie, Li, Zhe, Liu, Qiqi, Zhao, Rongping, Gao, Zhanxia, Midgley, Adam C, Qi, Tianyi, Tian, Jingwei, Zhang, Zhixuan, Kong, Deling, Tian, Jie, Yan, Xiyun, Huang, Xinglu. Machine-learning-assisted single-vessel analysis of nanoparticle permeability in tumour vasculatures. NATURE NANOTECHNOLOGY[J]. 2023, 第 13 作者  通讯作者  18(6): 657-+, http://dx.doi.org/10.1038/s41565-023-01323-4.
[19] Li, QiaoZhi, Fan, Huizhen, Wang, Zhenzhen, Zheng, JiaJia, Fan, Kelong, Yan, Xiyun, Gao, Xingfa. Mechanism and Kinetics-Guided Discovery of Nanometal Scissors to Cut Phosphoester Bonds. ACS CATALYSIS[J]. 2023, 第 6 作者13(1): 504-514, http://dx.doi.org/10.1021/acscatal.2c05094.
[20] 吴雪彤, 张若飞, 阎锡蕴, 范克龙. 纳米酶： 一种抗微生物感染新方法. 无机材料学报[J]. 2023, 第 3 作者38(1): 43-54, https://www.jim.org.cn/CN/10.15541/jim20220578.
[21] Jiewen Chen, Qingji Xu, Dan Liu, Xun Li, Mingyan Guo, Xuehui Chen, Jianyou Liao, Rong Lei, Wende Li, Hongyan Huang, Phei Er Saw, Erwei Song, Xiyun Yan, Yan Nie. CD146 promotes malignant progression of breast phyllodes tumor through suppressing DCBLD2 degradation and activating the AKT pathway. CANCER COMMUNICATIONS[J]. 2023, 第 13 作者  通讯作者  43(11): 1244-1266, http://lib.cqvip.com/Qikan/Article/Detail?id=7111820276.
[22] 张先恩, 汪卫华, 阎锡蕴, 潘教峰. 加强基础研究夯实科技自立自强根基. 中国科学院院刊[J]. 2023, 第 3 作者38(5): 755-758, http://lib.cqvip.com/Qikan/Article/Detail?id=7109755481.
[23] Jiang, Wei, Li, Qing, Zhang, Ruofei, Li, Jianru, Lin, Qianyu, Li, Jingyun, Zhou, Xinyao, Yan, Xiyun, Fan, Kelong. Chiral metal-organic frameworks incorporating nanozymes as neuroinflammation inhibitors for managing Parkinson's disease. NATURE COMMUNICATIONS[J]. 2023, 第 8 作者  通讯作者  14(1): http://dx.doi.org/10.1038/s41467-023-43870-3.
[24] Xiyun Yan, zixia zhang, Joao Conniot, Joana Amorim, Yiliang Jin, Rajendra Prasad. Nucleic acid-based therapy for brain cancer: Challenges and strategies. J Control Release[J]. 2022, 第 1 作者  通讯作者  
[25] Muhammad, Pir, Hanif, Sumaira, Li, Jingyun, Guller, Anna, Rehman, Fawad Ur, Ismail, Muhammad, Zhang, Dongya, Yan, Xiyun, Fan, Kelong, Shi, Bingyang. Carbon dots supported single Fe atom nanozyme for drug-resistant glioblastoma therapy by activating autophagy-lysosome pathway (vol 45, 101530, 2022). NANO TODAY. 2022, 第 8 作者  通讯作者  47: http://dx.doi.org/10.1016/j.nantod.2022.101629.
[26] Duan, Hongxia, Jing, Lin, Xiang, Jianquan, Ju, Chenhui, Wu, Zhenzhen, Liu, Jingyu, Ma, Xinran, Chen, Xuehui, Liu, Zheng, Feng, Jing, Yan, Xiyun. CD146 Associates with Gp130 to Control a Macrophage Pro-inflammatory Program That Regulates the Metabolic Response to Obesity. ADVANCED SCIENCE[J]. 2022, 第 11 作者  通讯作者  9(13): http://dx.doi.org/10.1002/advs.202103719.
[27] Wang, Zhuoran, Zhao, Yue, Zhang, Shuai, Chen, Xuehui, Sun, Guoming, Zhang, Baoli, Jiang, Bing, Yang, Yili, Yan, Xiyun, Fan, Kelong. Re-engineering the inner surface of ferritin nanocage enables dual drug payloads for synergistic tumor therapy. THERANOSTICS[J]. 2022, 第 9 作者  通讯作者  12(4): 1800-1815, http://dx.doi.org/10.7150/thno.68459.
[28] Li, QiaoZhi, Fan, Huizhen, Wang, Zhenzhen, Zheng, JiaJia, Fan, Kelong, Yan, Xiyun, Gao, Xingfa. Mechanism and Kinetics-Guided Discovery of Nanometal Scissors to Cut Phosphoester Bonds. ACS CATALYSIS. 2022, 第 6 作者
[29] Zhang, Baoli, Chen, Xuehui, Tang, Guoheng, Zhang, Ruofei, Li, Jingyun, Sun, Guoming, Yan, Xiyun, Fan, Kelong. Constructing a nanocage-based universal carrier for delivering TLR- activating nucleic acids to enhance antitumor immunotherapy. NANO TODAY[J]. 2022, 第 7 作者  通讯作者  46: http://dx.doi.org/10.1016/j.nantod.2022.101564.
[30] Xiyun Yan. Edge-Site Engineering of Defective Fe-N4 Nanozymes with Boosted Catalase-Like Performance for Retinal Vasculopathies. Adv Mater[J]. 2022, 第 1 作者  通讯作者  
[31] Xue, Bai, Wang, Ping, Yu, Wenzhen, Feng, Jing, Li, Jie, Zhao, Rulian, Yang, Zhenglin, Yan, Xiyun, Duan, Hongxia. CD146 as a promising therapeutic target for retinal and choroidal neovascularization diseases. SCIENCE CHINA-LIFE SCIENCES[J]. 2022, 第 8 作者  通讯作者  65(6): 1157-1170, http://dx.doi.org/10.1007/s11427-021-2020-0.
[32] Meng, Xiangqin, Zou, Sijia, Li, Dandan, He, Jiuyang, Fang, Ling, Wang, Haojue, Yan, Xiyun, Duan, Demin, Gao, Lizeng. Nanozyme-strip for rapid and ultrasensitive nucleic acid detection of SARS-CoV-2. BIOSENSORS & BIOELECTRONICS[J]. 2022, 第 7 作者  通讯作者  217: http://dx.doi.org/10.1016/j.bios.2022.114739.
[33] Zhang, Ronghan, Chen, Xiaogang, Chen, Shengwen, Tang, Jiajia, Chen, Feng, Lin, Yong, Reinach, Peter Sol, Yan, Xiyun, Tu, LiLi, Duan, Hongxia, Qu, Jia, Hou, Qiang. Inhibition of CD146 lessens uveal melanoma progression through reducing angiogenesis and vasculogenic mimicry. CELLULAR ONCOLOGY[J]. 2022, 第 8 作者45(4): 557-572, http://dx.doi.org/10.1007/s13402-022-00682-9.
[34] Zhang, Shuai, Zhang, Ruofei, Yan, Xiyun, Fan, Kelong. Nanozyme-Based Artificial Organelles: An Emerging Direction for Artificial Organelles. SMALL. 2022, 第 3 作者  通讯作者  18(33): https://www.doi.org/10.1002/smll.202202294.
[35] Wu, Zhenzhen, Liu, Jingyu, Chen, Gang, Du, Junfeng, Cai, Huiyun, Chen, Xuehui, Ye, Gaoqi, Luo, Yongting, Luo, Yiyi, Zhang, Liwen, Duan, Hongxia, Liu, Zheng, Yang, Sai, Sun, Hongwei, Cui, Yan, Sun, Lei, Zhang, Hongjie, Shi, Guizhi, Wei, Taotao, Liu, Pingsheng, Yan, Xiyun, Feng, Jing, Bu, Pengcheng. CD146 is a Novel ANGPTL2 Receptor that Promotes Obesity by Manipulating Lipid Metabolism and Energy Expenditure. ADVANCED SCIENCE[J]. 2021, 第 21 作者  通讯作者  8(6): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967059/.
[36] Zhang, Ruofei, Chen, Lei, Liang, Qian, Xi, Juqun, Zhao, Hanqing, Jin, Yiliang, Gao, Xingfa, Yan, Xiyun, Gao, Lizeng, Fan, Kelong. Unveiling the active sites on ferrihydrite with apparent catalase-like activity for potentiating radiotherapy. NANO TODAY[J]. 2021, 第 8 作者  通讯作者  41: http://dx.doi.org/10.1016/j.nantod.2021.101317.
[37] Meng, Xiangqin, Li, Dandan, Chen, Lei, He, Helen, Wang, Qian, Hong, Chaoyi, He, Jiuyang, Gao, Xingfa, Yang, Yili, Jiang, Bing, Nie, Guohui, Yan, Xiyun, Gao, Lizeng, Fan, Kelong. High-Performance Self-Cascade Pyrite Nanozymes for Apoptosis-Ferroptosis Synergistic Tumor Therapy. ACS NANO[J]. 2021, 第 12 作者  通讯作者  15(3): 5735-5751, http://dx.doi.org/10.1021/acsnano.1c01248.
[38] Zhao, Hanqing, Zhang, Ruofei, Yan, Xiyun, Fan, Kelong. Superoxide dismutase nanozymes: an emerging star for anti-oxidation. JOURNAL OF MATERIALS CHEMISTRY B. 2021, 第 3 作者  通讯作者  9(35): 6939-6957, http://dx.doi.org/10.1039/d1tb00720c.
[39] Xi, Juqun, Zhang, Ruofei, Wang, Liming, Xu, Wei, Liang, Qian, Li, Jingyun, Jiang, Jian, Yang, Yili, Yan, Xiyun, Fan, Kelong, Gao, Lizeng. A Nanozyme-Based Artificial Peroxisome Ameliorates Hyperuricemia and Ischemic Stroke. ADVANCED FUNCTIONAL MATERIALS[J]. 2021, 第 9 作者  通讯作者  31(9): http://dx.doi.org/10.1002/adfm.202007130.
[40] 阎锡蕴组. Synergistic Chemotherapy: Bioengineered Dual‐Targeting Protein Nanocage for Stereoscopical Loading of Synergistic Hydrophilic/Hydrophobic Drugs to Enhance Anticancer Efficacy. Advanced Functional Materials. 2021, 
[41] Liu, Qiqi, Tian, Jingwei, Liu, Jinjian, Zhu, Mingsheng, Gao, Zhanxia, Hu, Xueyan, Midgley, Adam C, Wu, Jin, Wang, Xinyue, Kong, Deling, Zhuang, Jie, Liu, Jianfeng, Yan, Xiyun, Huang, Xinglu. Modular Assembly of Tumor-Penetrating and Oligomeric Nanozyme Based on Intrinsically Self-Assembling Protein Nanocages. ADVANCED MATERIALS[J]. 2021, 第 13 作者33(39): http://dx.doi.org/10.1002/adma.202103128.
[42] Zhang, Yanan, Li, Yingni, Zhang, Jianlin, Chen, Xuehui, Zhang, Ruofei, Sun, Guoming, Jiang, Bing, Fan, Kelong, Li, Zhanguo, Yan, Xiyun. Nanocage-Based Capture-Detection System for the Clinical Diagnosis of Autoimmune Disease. SMALL[J]. 2021, 第 10 作者  通讯作者  17(25): http://dx.doi.org/10.1002/smll.202101655.
[43] Duan, Hongxia, Jing, Lin, Jiang, Xiaoqing, Ma, Yanbin, Wang, Daji, Xiang, Jianquan, Chen, Xuehui, Wu, Zhenzhen, Yan, Huiwen, Jia, Junying, Liu, Zheng, Feng, Jing, Zhu, Mingzhao, Yan, Xiyun. CD146 bound to LCK promotes T cell receptor signaling and antitumor immune responses in mice. JOURNAL OF CLINICAL INVESTIGATION[J]. 2021, 第 14 作者  通讯作者  131(21): 
[44] Zhang, Baoli, Tang, Guoheng, He, Jiuyang, Yan, Xiyun, Fan, Kelong. Ferritin nanocage: A promising and designable multi-module platform for constructing dynamic nanoassembly-based drug nanocarrier. ADVANCED DRUG DELIVERY REVIEWS. 2021, 第 4 作者  通讯作者  176: http://dx.doi.org/10.1016/j.addr.2021.113892.
[45] Duan, Hongxia, Zhao, Shuai, Xiang, Jianquan, Ju, Chenhui, Chen, Xuehui, Gramaglia, Irene, Yan, Xiyun. Targeting the CD146/Galectin-9 axis protects the integrity of the blood-brain barrier in experimental cerebral malaria. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2021, 第 7 作者  通讯作者  18(10): 2443-2454, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000590261200001.
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[47] Chen, Xuehui, Yan, Huiwen, Liu, Dan, Xu, Qingji, Duan, Hongxia, Feng, Jing, Yan, Xiyun, Xie, Can. Structure basis for AA98 inhibition on the activation of endothelial cells mediated by CD146. ISCIENCE[J]. 2021, 第 7 作者  通讯作者  24(5): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093899/.
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[49] Zhang, Ruofei, Fan, Kelong, Yan, Xiyun. Nanozymes: created by learning from nature. SCIENCE CHINA-LIFE SCIENCES[J]. 2020, 第 3 作者  通讯作者  63(8): 1183-1200, http://lib.cqvip.com/Qikan/Article/Detail?id=7102433154.
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[51] Liang, Qian, Xi, Juqun, Gao, Xuejiao J, Zhang, Ruofei, Yang, Yili, Gao, Xingfa, Yan, Xiyun, Gao, Lizeng, Fan, Kelong. A metal-free nanozyme-activated prodrug strategy for targeted tumor catalytic therapy. NANO TODAY[J]. 2020, 第 7 作者  通讯作者  35: http://dx.doi.org/10.1016/j.nantod.2020.100935.
[52] Xiaojing Cheng, Kelong Fan, Lin Wang, Xiangji Ying, Andrew J Sanders, Ting Guo, Xiaofang Xing, Meng Zhou, Hong Du, Ying Hu, Huirong Ding, Ziyu Li, Xianzi Wen, Wenguo Jiang, Xiyun Yan, Jiafu Ji. TfR1 binding with H-ferritin nanocarrier achieves prognostic diagnosis and enhances the therapeutic efficacy in clinical gastric cancer. CELL DEATH AND DISEASE[J]. 2020, 第 15 作者11(2): 1-13, http://dx.doi.org/10.1038/s41419-020-2272-z.
[53] 阎锡蕴组. Nanozyme chemiluminescence paper test for rapid and sensitive diagnosis of SARS-CoV-2 infection. Biosensors and Bioelectronics. 2020, 
[54] Ding, Hui, Hu, Bing, Zhang, Bin, Zhang, Han, Yan, Xiyun, Nie, Guohui, Liang, Minmin. Carbon-based nanozymes for biomedical applications. NANO RESEARCH. 2020, 第 5 作者  通讯作者  https://www.webofscience.com/wos/woscc/full-record/WOS:000573197300002.
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