基本信息
赖仞  男  博导  中国科学院昆明动物研究所
电子邮件: rlai@mail.kiz.ac.cn
通信地址: 云南省昆明市教场东路32号
邮政编码: 650223

招生信息

   
招生专业
071010-生物化学与分子生物学
100703-生药学
100706-药理学
招生方向
天然药物功能蛋白质组学
动物毒素
心血管药理学

教育背景

1995-09--2001-07   中国科学院昆明动物研究所   博士
1991-09--1995-07   西南师范大学   学士

工作经历

   
工作简历
2004-07~现在, 中国科学院昆明动物研究所, 研究员
2002-05~2004-06,英国利物浦大学, 博士后
2001-08~2002-04,中国科学院昆明动物研究所, 助理研究员
社会兼职
2016-12-31-今,云南省多肽研究与利用重点实验室主任, 主任
2014-08-01-今,云南省天然活性多肽工程实验室, 实验室主任
2013-10-01-今,Toxin, 编委
2013-06-01-今,云南省生物化学与分子生物学学会, 副理事长
2010-01-01-今,Journal of Venom Research, 副主编
2008-01-01-今,中国天然药物, 编委

专利与奖励

   
奖励信息
(1) 中医药创新突出贡献奖, 部委级, 2016
(2) 全国创新争先奖状, 国家级, 2016
(3) 基于生物生存策略的有毒动 物中药功能成分定向挖掘技术体系, 二等奖, 国家级, 2013
(4) 中国青年科技奖, , 部委级, 2011
(5) 中国科学院科学院十大杰出青年, , 部委级, 2010
(6) 谈家桢生命科学奖, , 部委级, 2010
(7) 中国科学院王宽诚西部突出贡献奖, , 部委级, 2010
(8) 吸血蜱与宿主相互作用的分子机制, 二等奖, 省级, 2009
(9) 两栖动物功能活性多肽的结构与功能, 一等奖, 省级, 2008
专利成果
[1] 魏辅文, 赖仞, 周文良, 杨仕隆, 李博文, 聂永刚. 一种影响人和动物对冷感知的化合物及其应用. CN: CN112107563B, 2021-07-23.

[2] 赖仞, 龙承波, 周梦, 许宽宏, 吴飞龙. 一种活性蛋白HMEI-A、活性蛋白HMEI-A的编码基因及应用. CN: CN111454352B, 2021-07-23.

[3] 赖仞, 唐小芃, 常佳佳. SPINK6在作为检测艾滋病的标志物中的应用. CN: CN111693716B, 2021-07-13.

[4] 季旻珺, 赖仞, 倪杨玥, 徐志鹏, 栾宁. 一种多肽、制备方法及应用. CN: CN112707959A, 2021-04-27.

[5] 赖仞, 彭小忠, 唐小芃, 廖祉亦, 鲁帅尧, 刘红旗. 转铁蛋白、转铁蛋白受体及其抗体在制备抗SARS-CoV-2病毒的药物中的应用. CN: CN111714621B, 2021-04-27.

[6] 赖仞, 彭小忠, 王淦, 龙承波, 刘红旗, 杨梦莉. 达巴万星在制备抑制SARS-CoV-2与ACE2结合的药物中的应用. CN: CN111686240B, 2021-04-09.

[7] 赖仞, 唐小芃, 廖祉亦. 干扰多肽在制备抗SARS-CoV-2药物中的应用. CN: CN111647048B, 2021-04-02.

[8] 赖仞, 孟平. 一种抗菌肽和线粒体DNA复合物及其多克隆抗体和应用. CN: CN110812480B, 2021-04-02.

[9] 赖仞, 罗雷, 韩亚蓝, 罗安纳. citrusinine-II在制备影响人和动物对痒和痛感知的试剂中的应用. CN: CN112426425A, 2021-03-02.

[10] 赖仞, 申传斌, 吕秋敏, 刘明, 李东升. 十八烷基化修饰的R18-7AA多肽及其衍生多肽的应用. CN: CN111870700A, 2020-11-03.

[11] 赖仞, 唐小芃, 程若梅, 吕秋敏. 检测或调控乳铁蛋白表达量的物质在制备预防和/或治疗心脑血管疾病药物或试剂盒的应用. CN: CN111879949A, 2020-11-03.

[12] 赖仞, 申传斌, 吕秋敏, 刘明, 李东升. 十八烷基化修饰的多肽在制备抑制血小板聚集的药物中的应用. CN: CN111773376A, 2020-10-16.

[13] 赖仞, 方鸣谦, 唐小芃, 张治业. 布氏鼠耳蝠白三烯A4水解酶抑制剂Motistin的成熟肽及其应用. CN: CN111620942A, 2020-09-04.

[14] 赖仞, 申传斌, 吕秋敏, 刘明. 3,4,7-三羟基异黄酮或3-甲氧基大豆素在制备抑制血小板聚集和血栓药物中的应用. CN: CN106822090B, 2020-08-28.

[15] 赖仞, 唐小芃, 方鸣谦. 转铁蛋白在制备免疫抑制剂类药物中的应用. CN: CN111166872A, 2020-05-19.

[16] 赖仞, 杨仕隆, 罗雷. 一种蜈蚣多肽SLP_SsTx及其编码基因和应用. CN: CN107987144B, 2020-05-15.

[17] 赖仞, 方鸣谦, 韩亚君. 一种森林山蛭抗血栓多肽Sylvestin及其体外表达制备方法和应用. CN: CN108101975B, 2020-05-15.

[18] 赖仞, 唐小芃, 许宽宏, 方鸣谦. 转铁蛋白或过表达转铁蛋白在制备治疗和/或预防溃疡性结肠炎的药物中的应用. CN: CN111110834A, 2020-05-08.

[19] 赖仞, 张治业, 唐小芃, 方鸣谦. 一种抗凝多肽TH16及其应用. CN: CN108640979B, 2020-02-21.

[20] 赖仞, 张治业, 唐小芃. 转铁蛋白标志物及其应用. CN: CN107831315B, 2019-11-05.

[21] 赖仞, 龙承波, 龙爱琳, 吕秋敏. 一种干预AD用的美洲大蠊提取物及其提取方法和应用. CN: CN108403723B, 2019-09-13.

[22] 赖仞, 何小芹. Prokineticin 2试剂在银屑病检测与治疗方面的新用途. CN: CN106324259B, 2019-06-04.

[23] 罗晓东, 刘亚平, 王蓓, 赖仞, 罗雷, 赵云丽, 尚建华. 紫金龙素类衍生物及其药物组合物、制备方法和用途. CN: CN109810058A, 2019-05-28.

[24] 赖仞, 龙承波, 赖艳梅, 李博文. 菲牛蛭Kazal型胰蛋白酶抑制剂Bdellin-HM及其编码基因和应用. CN: CN105646702B, 2019-03-01.

[25] 赖仞, 龙承波, 唐小芃. 抗转铁蛋白抗体及其用途. CN: CN109336973A, 2019-02-15.

[26] 赖仞, 唐小芃, 张治业, 方鸣谦. 一种抗凝多肽FX18及其应用. 中国: CN108586582A, 2018.09.28.

[27] 赖仞, 吕秋敏, 李东升. 一种抗凝肽SYAP-1及其突变体和包括抗凝肽和/或突变体的抑制剂. 中国: CN108017693A, 2018.05.11.

[28] 赖仞, 刘伟慧, 龙承波, 吕秋敏. 森林山蛭抗血栓肽Sylvestin及其基因和应用. 中国: CN108059672A, 2018-05-22.

[29] 赖仞, 容明强, 杜彦军. 一种小分子多肽ZY4及其应用. 中国: CN104974228B, 2017-10-17.

[30] 赖仞, 申传斌, 吕秋敏, 刘明. 3,4,7‑三羟基异黄酮或3‑甲氧基大豆素在制备抑制炎症和脑缺血药物的应用. 中国: CN106860444A, 2017-06-20.

[31] 赖仞, 龙承波, 吕秋敏, 容明强. 森林山蛭镇痛肽mh2620及其基因和应用. 中国: CN105732789A, 2016-07-06.

[32] 赖仞, 王淦, 容明强. 香豆素β抑制癌细胞生长的应用. 中国: CN105287510A, 2016-02-03.

[33] 赖仞, 杨仕隆. 蜈蚣镇痛多肽SLP_RhTx及其基因和应用. 中国: CN105085646A, 2015-11-25.

[34] 赖仞, 容明强, 白雪维. 姜黄素在制备治疗自身免疫疾病药物中的应用. 中国: CN104814946A, 2015-08-05.

[35] 赖仞, 张治业, 韩亚君. 一种小分子多肽LZ1的应用. 中国: CN104623628A, 2015-05-20.

[36] 赖仞, 张治业. LL-37-mtDNA复合物标志物及其应用. 中国: CN104480199A, 2015-04-01.

[37] 赖仞, 容明强, 木丽仙. 红瘰疣螈皮肤修复肽cathelicidin-TV2的应用. 中国: CN104288750A, 2015-01-21.

[38] 杜彦军, 刘音, 赖仞, 容明强. 一种小分子多肽ZY13及其应用. 中国: CN103275190A, 2013.09.04.

[39] 赖仞, 马东莹. 姚虻纤维蛋白原水解酶tabfiblysin及其基因和应用. 中国: CN103282091A, 2013.09.04.

[40] 赖仞, 安输, 容明强, 李东升. 尘螨过敏原Derf29和Derf30及其基因和应用. 中国: CN103073636A, 2013.05.01.

[41] 赖仞, 张治业, 高蓝. 姚虻抗血栓多肽vasotab TY的应用. 中国: CN103463622A, 2013-12-25.

[42] 杜彦军, 刘音, 赖仞, 容明强, 朱玉琴. 一种镇痛肽FI及其基因和应用. 中国: CN103275187A, 2013-09-04.

[43] 赖仞, 郝雪, 刘欢. 人干细胞自我更新支持因子在肝癌靶向治疗中的应用. 中国: CN103223166A, 2013-07-31.

[44] 赖仞, 郝雪, 刘欢. 人干细胞自我更新支持因子(hSDNSF)的体外重组表达技术. 中国: CN103224948A, 2013-07-31.

[45] 赖仞, 安输, 容明强, 李东升. 尘螨过敏原Derf8和Derf20及其基因和应用. 中国: CN103215236A, 2013-07-24.

[46] 赖仞, 安输, 容明强, 李东升. 尘螨过敏原Derf24和Derf25及其基因和应用. 中国: CN103214565A, 2013-07-24.

[47] 赖仞, 安输, 容明强, 李东升. 尘螨过敏原Derf26和Derf27及其基因和应用. 中国: CN103059120A, 2013-04-24.

[48] 赖仞, 安输, 容明强, 李东升. 尘螨过敏原Der f 28及其基因和应用. 中国: CN103059119A, 2013-04-24.

[49] 赖仞, 容明强, 杨仕隆, 肖瑶, 康迪. 少棘蜈蚣多肽毒素mu-SLPTX-Ssm6a及其基因和应用. 中国: CN102977201A, 2013-03-20.

[50] 赖仞, 容明强, 李建云. 山羊抗菌肽GC41的应用. 中国: CN102961736A, 2013-03-13.

[51] 赖仞, 容明强. 调节肽GM21在制备调节山羊免疫功能药物中的应用. 中国: CN102961735A, 2013-03-13.

[52] 赖仞, 容明强. 多肽DZ24在制备治疗山羊细菌或真菌性炎症药物中的应用. 中国: CN102961737A, 2013-03-13.

[53] 赖仞, 容明强. 多肽CA19在制备山羊饲料添加剂中的应用. 中国: CN102940133A, 2013-02-27.

[54] 赖仞, 容明强. 多肽DM29在制备增加山羊天然免疫功能药物中的应用. 中国: CN102940877A, 2013-02-27.

[55] 赖仞, 容明强. 小分子多肽CW14在制备山羊抗菌药物中的应用. 中国: CN102940874A, 2013-02-27.

[56] 赖仞, 容明强. 多肽GH27在制备预防及治疗山羊腹泻药物中的应用. 中国: CN102940876A, 2013-02-27.

[57] 赖仞, 容明强, 李建云. 多肽GC25在制备治疗抗感染药物中的应用. 中国: CN102935223A, 2013-02-20.

[58] 赖仞, 张治业. 抗菌肽LZ1和该抗菌肽在制备抗菌药物中的用途. 中国: CN102924574A, 2013-02-13.

[59] 赖仞, 杨仕隆, 容明强. 少棘蜈蚣多肽毒素omega-SLPTX-Ssm1a的应用. 中国: CN102671185A, 2012.09.19.

[60] 赖仞, 容明强, 刘涵. 无指盘臭蛙促皮肤修复多肽AH90和CW49的应用. 中国: CN102657845A, 2012-09-12.

[61] 赖仞, 杨海龙, 王义鹏, 肖瑶. 地鳖虫抗血栓酶Eupolytin1及其基因和应用. 中国: CN102199584A, 2011.09.28.

[62] 赖仞, 张治业, 李东升, 刘蕊. 金环蛇抗菌肽cathelicidin-BF的应用. 中国: CN102294019A, 2011-12-28.

[63] 赖仞, 武静, 刘涵. 华南雨蛙促皮肤损伤修复多肽及其基因和应用. 中国: CN102250217A, 2011-11-23.

[64] 赖仞, 杨海龙, 刘涵, 肖瑶. D29分枝杆菌噬菌体来源的PK34多肽及其应用. 中国: CN102241748A, 2011-11-16.

[65] 赖仞, 马冬莹. 牛虻抗血栓酶tablysin及其基因和应用. 中国: CN102071184A, 2011-05-25.

[66] 赖仞, 刘存宝, 杨海龙, 李东升. 大绿蛙抗氧化肽antioxidin-RL及其基因和应用. 中国: CN101824077A, 2010.09.08.

[67] 赖仞, 李建许, 徐学清, 李东升. 无指盘臭蛙臭蛙肽及其基因和在制药中的应用. 中国: CN101012274, 2007.08.08.

[68] 赖仞, 李建许, 李东升. 无指盘臭蛙抑生肽、其基因和变异体及其在制药中的应用. 中国: CN101012276, 2007.08.08.

[69] 赖仞, 李建许, 李东升, 宋玉竹. 无指盘臭蛙免疫调节肽、其基因和变异体及其在制药中的应用. 中国: CN101037473, 2007-09-19.

[70] 赖仞, 李建许, 李东升, 杨海龙. 无指盘臭蛙蛙皮肽及其基因和在制药中的应用. 中国: CN101012275, 2007-08-08.

[71] 赖仞, 李建许, 李东升, 徐学清, 韩耀平. 无指盘臭蛙分泌肽及其基因和在制药中的应用. 中国: CN101012273, 2007-08-08.

[72] 赖仞, 李建许, 王义鹏, 李东升. 无指盘臭蛙抗微生物多肽及其基因和在制药上的应用. 中国: CN101012278, 2007-08-08.

[73] 赖仞, 李建许, 李东升, 马冬莹. 无指盘臭蛙皮肤活性肽及其基因和在制药中的应用. 中国: CN101012277, 2007-08-08.

[74] 赖仞, 李建许, 韩耀平, 李东升, 梁建国, 徐学清, 杨海龙. 无指盘臭蛙丝氨酸蛋白酶抑制剂及其基因和应用. 中国: CN1883703, 2006-12-27.

[75] 赖仞, 李健许, 徐学清, 杨海龙. 中华硬蜱神经肽及其制备方法和应用. 中国: CN1285607, 2006-11-22.

[76] 赖仞, 李建许, 梁建国, 徐学清, 李东升, 李宗杰. 无指盘臭蛙胰岛素释放促进因子和在制药中的应用. 中国: CN1847264, 2006-10-18.

[77] 张云, 赖仞, 刘衡, 李文辉. 酸性抗菌肽及其基因和在制药中的应用. 中国: CN1238377, 2006-01-25.

[78] 张云, 赖仞. 血管收缩因子及其制备方法和在制药中的应用. 中国: CN1209371, 2005.07.06.

[79] 张云, 赖仞, 刘衡, 李文辉. 饱食因子及其制备方法. 中国: CN1189480, 2005-02-16.

[80] 张云, 赖仞, 刘衡, 李文辉. 大蹼铃蟾缓激肽及其制备方法和其基因. 中国: CN1390848, 2003-01-15.

[81] 张云, 赖仞, 李文辉, 刘衡. 大蹼铃蟾神经营养肽及其制备方法和其基因. 中国: CN1390849, 2003-01-15.

[82] 张云, 赖仞, 刘衡, 李文辉. 大蹼铃蟾铃蟾肽及其制备方法和其基因. 中国: CN1390851, 2003-01-15.

[83] 张云, 赖仞, 刘衡, 李文辉. 大蹼铃蟾神经营养因子及其制备方法和其基因. 中国: CN1390850, 2003-01-15.

[84] 张云, 赖仞, 刘衡, 李文辉. 大蹼铃蟾血管扩张因子及其制备方法和其基因. 中国: CN1374324, 2002-10-16.

[85] 张云, 赖仞, 郑永唐, 李文辉, 刘衡, 刘广杰. 大蹼铃蟾抗肿瘤蛋白及其制备方法和其基因. 中国: CN1374323, 2002-10-16.

[86] 张云, 赖仞, 刘衡, 李文辉. 大蹼铃蟾抗微生物肽及其制备方法和其基因. 中国: CN1374325, 2002-10-16.

[87] 张云, 赖仞, 郑永唐, 李文辉. 大蹼铃蟾抗精子多肽及其制备方法和在制药中的应用. 中国: CN1345883, 2002-04-24.

[88] 张云, 赖仞, 郑永唐, 刘广杰, 李文辉, 唐绍宗. 大蹼铃蟾多肽及其制备方法和在制药中的应用. 中国: CN1336386, 2002-02-20.

[89] 张云, 赖仞, 郑永唐, 唐绍宗, 李文辉. 大蹼铃蟾皮肤肽及其制备方法和在制药中的应用. 中国: CN1336384, 2002-02-20.

[90] 张云, 赖仞. 大蹼铃蟾抗菌肽及其制备方法和在制药中的应用. 中国: CN1336383, 2002-02-20.

[91] 张云, 赖仞, 郑永唐, 唐绍宗, 李文辉. 大蹼铃蟾蛋白酶抑制剂及其制备方法和在制药中的应用. 中国: CN1336385, 2002-02-20.

出版信息

   
发表论文
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[2] Shen, Chuanbin, Liu, Ming, Mackeigan, Daniel Thomas, Chen, Zi Yan, Chen, Pingguo, Karakas, Danielle, Li, June, Norris, Peter A A, Li, Jiayao, Deng, Yanling, Long, Chengbo, Lai, Ren, Ni, Heyu. Viper venoms drive the macrophages and hepatocytes to sequester and clear platelets: novel mechanism and therapeutic strategy for venom-induced thrombocytopenia. ARCHIVES OF TOXICOLOGY[J]. 2021, 95(11): 3589-3599, http://dx.doi.org/10.1007/s00204-021-03154-5.
[3] Tengyu Zhu, Xue Chen, Huan Qiu, Yang Liu, James Mwangi, Ling Zhao, Wenjun Ding, Ren Lai, Lin Jin. Aspirin Alleviates Particulate Matter Induced Asymptomatic Orchitis of Mice via Suppression of cGAS-STING Signaling. Frontiers in Immunology[J]. 2021, 12: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673441/.
[4] Chengbo Long, Feilong Wu, Qiumin Lu, Bing Xie, Chuanbin Shen, Jiayao Li, Yanling Deng, Ping Liang, Yongzhi Yu, Ren Lai. A Strategy for Efficient Preparation of Genus-Specific Diagnostic Antibodies for Snakebites. Frontiers in Immunology[J]. 2021, 12: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660121/.
[5] Pitchayakarn Takomthong, Pornthip Waiwut, Chavi Yenjai, Aonnicha Sombatsri, Prasert Reubroycharoen, Luo Lei, Ren Lai, Suchada Chaiwiwatrakul, Chantana Boonyarat. Multi-Target Actions of Acridones from Atalantia monophylla towards Alzheimer’s Pathogenesis and Their Pharmacokinetic Properties. Pharmaceuticals[J]. 2021, 14(888): [6] Jingjing Wang, Mengyao Ji, Bingqian Yuan, Anna Luo, Zhenyuan Jiang, Tengyu Zhu, Yang Liu, Peter Muiruri Kamau, Lin Jin, Ren Lai. Peptide OPTX-1 From Ornithodoros papillipes Tick Inhibits the pS273R Protease of African Swine Fever Virus. Frontiers in Microbiology[J]. 2021, 12: [7] Zhu, TengYu, Qiu, Huan, Cao, QiQi, Duan, ZiLei, Liu, FengLiang, Song, TianZhang, Liu, Yang, Fang, YaQun, Wu, GuangMing, Zheng, YongTang, Ding, WenJun, Lai, Ren, Jin, Lin. Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice. ZOOLOGICAL RESEARCH[J]. 2021, 42(3): 335-+, http://dx.doi.org/10.24272/j.issn.2095-8137.2021.088.
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[9] Min Zhang, Zhi Dai, Xudong Zhao, Gan Wang, Ren Lai. Anticarin β Inhibits Human Glioma Progression by Suppressing Cancer Stemness via STAT3. Frontiers in Oncology[J]. 2021, 11: https://doaj.org/article/1e1e93ad2bc143f8aae133bc3f8db8c0.
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[17] Chang, Jiajia, He, Xiaoqin, Hu, Jingmei, Kamau, Peter Muiruri, Lai, Ren, Rao, Dingqi, Luo, Lei. Bv8-Like Toxin from the Frog Venom of Amolops jingdongensis Promotes Wound Healing via the Interleukin-1 Signaling Pathway. TOXINS[J]. 2020, 12(1): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000514630000006.
[18] Sun, Ruipu, Ying, Ying, Tang, Zhimin, Liu, Ting, Shi, Fuli, Li, Huixia, Guo, Taichen, Huang, Shibo, Lai, Ren. The Emerging Role of the SLCO1B3 Protein in Cancer Resistance. PROTEIN AND PEPTIDE LETTERSnull. 2020, 27(1): 17-29, https://www.webofscience.com/wos/woscc/full-record/WOS:000505771900003.
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[20] Li, Pengpeng, Zhang, Zhongzhe, Liao, Qiong, Meng, Er, Mwangi, James, Lai, Ren, Rong, Mingqiang. LCTX-F2, a Novel Potentiator of Coagulation Factors From the Spider Venom ofLycosa singoriensis. FRONTIERS IN PHARMACOLOGY[J]. 2020, 11: https://doaj.org/article/bf0fe1309869494cb0259dfb0d77b448.
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[22] Ren Lai. Conformation-Specific Blockade of αIIbβ3 by a Non-RGD Peptide to Inhibit Platelet Activation without Causing Significant Bleeding and Thrombocytopenia.. Thromb Haemost.. 2020, [23] Tian, Huiwen, Liu, Ming, Li, Jiameng, Xu, Runjia, Long, Chengbo, Li, Hao, Mwangi, James, Lu, Qiumin, Lai, Ren, Shen, Chuanbin. Snake C-Type Lectins Potentially Contribute to the Prey Immobilization in Protobothrops mucrosquamatus and Trimeresurus stejnegeri Venoms. TOXINS[J]. 2020, 12(2): https://www.webofscience.com/wos/woscc/full-record/WOS:000519117300005.
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[34] Ren Lai. Bv8-Like Toxin from the Frog Venom of Amolops jingdongensis Promotes Wound Healing via the Interleukin-1 Signaling Pathway.. Toxins (Basel).. 2019, [35] Xu Runjia, Fei Shuohan, Chen Linyan, Wang Gan, Liu Ming, Zhang Wensheng, Yan Xiuwen, Lai Ren, Shen Chuanbin. 3′-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels. Chinese Journal of Natural Medicines[J]. 2019, 17(6): 413-423, http://dx.doi.org/10.1016/S1875-5364(19)30049-4.
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[37] Gao, Zhengrong, Xing, Keke, Zhang, Chang, Qi, Jianxun, Wang, Liang, Gao, Shan, Lai, Ren. Crystal structure and function of Rbj: A constitutively GTP-bound small G protein with an extra DnaJ domain. PROTEIN & CELLnull. 2019, 10(10): 760-763, http://lib.cqvip.com/Qikan/Article/Detail?id=7100271927.
[38] Ji, Mengyao, Zhu, Tengyu, Xing, Meichen, Luan, Ning, Mwangi, James, Yan, Xiuwen, Mo, Guoxiang, Rong, Mingqiang, Li, Bowen, Lai, Ren, Jin, Lin. An Antiviral Peptide from Alopecosa nagpag Spider Targets NS2B-NS3 Protease of Flaviviruses. TOXINS[J]. 2019, 11(10): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000493542500044.
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[43] Mwangi, James, Yin, Yizhu, Wang, Gan, Yang, Min, Li, Ya, Zhang, Zhiye, Lai, Ren. The antimicrobial peptide ZY4 combats multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii infection. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2019, 116(52): 26516-26522, https://www.webofscience.com/wos/woscc/full-record/WOS:000504656900056.
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[192] 李建许, 徐学清, 杨海龙, 刘彤光, 赖仞. 两种蚂蚁巢甲醇提取物的自由基清除及抗菌活性研究. 中国天然药物[J]. 2006, 4(4): 295-298, http://159.226.149.42:8080/handle/152453/1091.
[193] 李建许, 刘彤光, 杨海龙, 徐学清, 刘志刚, 赖仞. 从中华硬蜱神经节中分离出两种神经肽. 科学通报[J]. 2006, 51(21): 2501-2504, http://www.irgrid.ac.cn/handle/1471x/1149542.
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[195] 李建许, 徐学清, 杨海龙, 刘彤光, 赖仞. Radical Scavenging and Antimicrobial Activities of Methanol Extracts of Two Kinds of Formicary. 中国天然药物[J]. 2006, 4(4): 295-298, http://159.226.149.42:8080/handle/152453/1091.
[196] Lu, Yi, Li, Jianxu, Yu, Haining, Xu, Xueqing, Liang, Jianguo, Tian, Yongqiang, Ma, Dongying, Lin, Guoqing, Huang, Guoqiang, Lai, Ren. Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis. PEPTIDES[J]. 2006, 27(12): 3085-3091, http://dx.doi.org/10.1016/j.peptides.2006.08.017.
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[198] Zhou, Zuohong, Yang, Hailong, Xu, Xueqing, Wang, Xu, Lai, Ren. The first report of kininogen from invertebrates. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2006, 347(4): 1099-1102, http://159.226.149.42:8080/handle/152453/2487.
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[200] Xu, Xueqing, Yang, Hailong, Yu, Haining, Li, Jianxu, Lai, Ren. The mastoparanogen from wasp. PEPTIDES[J]. 2006, 27(12): 3053-3057, http://dx.doi.org/10.1016/j.peptides.2006.09.003.
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[202] 王利菊, 高国富, 柏士平, 刘至刚, 梁建国, 张克云, 赖仞. 中华硬蜱凝血酶抑制剂的分离纯化与活性. 动物学研究[J]. 2005, 26(3): 328 - 331, http://159.226.149.42:8080/handle/152453/1218.
[203] 安贤惠, 吕毅, 李卫国, 梁建国, 徐春花, 张崇星, 董靖, 赖仞. 中国对虾PC2 Ⅲ系列抗菌肽的分离纯化及活性. 动物学研究[J]. 2005, 26(4): 410 - 415, http://159.226.149.42:8080/handle/152453/1202.
[204] 刘勇厚, 徐春花, 刘至刚, 梁建国, 赖仞. 中华硬蜱血小板集聚抑制剂的分离纯化与活性研究. 中国寄生虫学与寄生虫病杂志[J]. 2005, 23(6): 424-427, http://159.226.149.42:8080/handle/152453/1221.
[205] 安贤惠, 吕毅, 李卫国, 梁建国, 徐春花, 张崇星, 董靖, 赖仞. 中国对虾PC2 Ⅲ系列抗菌肽的分离纯化及活性. 动物学研究[J]. 2005, 26(4): 410 - 415, http://159.226.149.42:8080/handle/152453/1202.
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[207] 刘勇厚, 徐春花, 刘至刚, 梁建国, 赖仞. 中华硬蜱血小板集聚抑制剂的分离纯化与活性研究. 中国寄生虫学与寄生虫病杂志[J]. 2005, 23(6): 424-427, http://159.226.149.42:8080/handle/152453/1221.
[208] 赖仞, 粱建国, 张云. 两栖类皮肤抗菌多肽及其应用. 动物学研究[J]. 2004, 25(5): 465 - 468, http://159.226.149.42:8080/handle/152453/1320.
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[210] 赖仞, 赵宇, 杨东明, 查宏光, 李文辉, 张云. 六种常见两栖类动物皮肤分泌物的生物活性比较. 动物学研究. 2002, 23(2): 113-119, http://lib.cqvip.com/Qikan/Article/Detail?id=6197023.
[211] Ren Lai, Hen Liu, Wen Hui Lee, Yun Zhang. Identification and cloning of a trypsin inhibitor from skin secretions of Chinese red-belly toad Bombina maxima. Comparative Biochemistry and Physiology, Part B[J]. 2002, 131(1): 47-53, http://dx.doi.org/10.1016/S1096-4959(01)00479-1.
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发表著作
(1) Combined peptidomics and genomics approach to the isolation of amphibian antimicrobial peptides. , Combined peptidomics and genomics approach to the isolation of amphibian antimicrobial peptides. , Springer, 2011-07, 第 1 作者

科研活动

   
科研项目
( 1 ) 吸血节肢动物成功吸血的分子机制, 主持, 国家级, 2010-01--2013-12
( 2 ) 牛虻作为传统抗血栓中药的物质基础, 主持, 国家级, 2011-07--2017-06
( 3 ) 两栖动物抗菌功能基因发掘及抗菌肽分子资源库的建立, 主持, 国家级, 2011-07--2011-07
( 4 ) 肿瘤氧化还原蛋白质组学, 参与, 国家级, 2013-01--2017-12
( 5 ) 两栖动物皮肤修复的分子机制研究, 主持, 国家级, 2014-01--2017-12
( 6 ) 天然活性多肽分子资源库的建设, 主持, 国家级, 2015-07--2018-06
( 7 ) 国家1类抗感染新药的临床前研究, 主持, 省级, 2016-09--2019-08
( 8 ) 蜈蚣毒素专一性Kv1.3抑制剂的药物化学及其对银屑病治疗的分子机制研究, 主持, 国家级, 2014-01--2017-12
( 9 ) 从非洲常见药用动物或有毒动物中识别具有药物潜力的生物活性分子, 主持, 部委级, 2016-01--2020-12
( 10 ) 动脉粥样硬化发病机理, 主持, 部委级, 2016-08--2020-12
( 11 ) 核仁素靶向的胰腺癌个性化先导化合物发现研究, 主持, 部委级, 2016-01--2017-12

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徐学清  博士研究生  071002-动物学  

李建许  博士研究生  071002-动物学  

宋玉竹  博士研究生  071002-动物学  

游德文  博士研究生  071002-动物学  

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杨海龙  博士研究生  071002-动物学  

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