基本信息

朱顺义 男 博导 中国科学院动物研究所
电子邮件: zhusy@ioz.ac.cn
通信地址: 北京市朝阳区北辰西路1号院5号
邮政编码: 100101
电子邮件: zhusy@ioz.ac.cn
通信地址: 北京市朝阳区北辰西路1号院5号
邮政编码: 100101
招生信息
招生专业
071010-生物化学与分子生物学
招生方向
多肽生物学及进化多肽新分子设计
教育背景
1997-09--2001-04 武汉大学 博士
工作经历
工作简历
2001-10~2004-04,Leuven University, 博士后1997-09~2001-04,武汉大学, 博士
社会兼职
2017-01-01-今,Scientific reports, 编委
2015-10-01-今,昆虫学报, 编委
2015-10-01-今,昆虫学报, 编委
教授课程
进化生态学:分子、化学和行为适应机制
专利与奖励
奖励信息
(1) 东亚钳蝎的毒素组学研究, 一等奖, 省级, 2005
专利成果
( 1 ) 一种抗真菌肽突变体及其制备方法和应用, 2021, 第 1 作者, 专利号: CN112794892A( 2 ) 蝎α‑型神经毒素的突变体及其用途, 2017, 第 1 作者, 专利号: CN107304226A( 3 ) 一种抗菌肽及其制备方法和应用, 2013, 第 1 作者, 专利号: CN103421100A
出版信息
发表论文
(1) Molecular Diversity and Evolution of Antimicrobial Peptides in Musca domestica, DIVERSITY-BASEL, 2021, 第 11 作者(2) How a Scorpion Toxin Selectively Captures a Prey Sodium Channel: The Molecular and Evolutionary Basis Uncovered, MOLECULAR BIOLOGY AND EVOLUTION, 2020, 第 11 作者(3) Scorpion Toxins: Positive Selection at a Distal Site Modulates Functional Evolution at a Bioactive Site, MOLECULAR BIOLOGY AND EVOLUTION, 2019, 第 11 作者(4) 蛇三指环毒素家族的研究进展, The research progress of three finger toxin family in snakes, 云南大学学报. 自然科学版, 2019, 第 3 作者(5) Did cis- and trans-defensins derive from a common ancestor?, IMMUNOGENETICS, 2019, 第 11 作者(6) Characterization of bi-domain drosomycin-type antifungal peptides in nematodes: An example of convergent evolution, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2018, 第 11 作者(7) Receptor variability-driven evolution of snake toxins, Receptor variability-driven evolution of snake toxins, 动物学研究, 2018, 第 4 作者(8) Loop Replacement Enhances the Ancestral Antibacterial Function of a Bifunctional Scorpion Toxin, TOXINS, 2018, 第 11 作者(9) Meucin-49, a multifunctional scorpion venom peptide with bactericidal synergy with neurotoxins, AMINO ACIDS, 2018, 第 11 作者(10) Mesobuthus Venom-Derived Antimicrobial Peptides Possess Intrinsic Multifunctionality and Differential Potential as Drugs, FRONTIERS IN MICROBIOLOGY, 2018, 第 11 作者(11) Characterization of bi-domain drosomycin-type antifungal peptides in nematodes: An example of convergent evolution, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2018, 第 11 作者(12) 抑制剂胱氨酸结多肽的抗菌和杀虫活性及进化, Antimicrobial and insecticidal activities and evolution of inhibitor cystine knot peptides, 昆虫学报, 2018, 第 4 作者(13) Molecular diversity of fungal inhibitor cystine knot peptides evolved by domain repeat and fusion, FEMS MICROBIOLOGY LETTERS, 2018, 第 11 作者(14) Molecular Dynamics Simulation Reveals Specific Interaction Sites between Scorpion Toxins and Kv1.2 Channel: Implications for Design of Highly Selective Drugs, TOXINS, 2017, 第 11 作者(15) New Fungal Defensin-Like Peptides Provide Evidence for Fold Change of Proteins in Evolution, BIOSCIENCE REPORTS, 2017, 第 11 作者(16) Expanding the Pharmacological Profile of ��-Hefutoxin 1 and Analogues: A Focus on the Inhibitory Effect on the Oncogenic Channel Kv10.1, PEPTIDES, 2017, 第 6 作者(17) Expanding the pharmacological profile of kappa-hefutoxin 1 and analogues: A focus on the inhibitory effect on the oncogenic channel K(v)10.1, PEPTIDES, 2017, 第 6 作者(18) Evaluating the Potential of a Loop-Extended Scorpion Toxin-Like Peptide as a Protein Scaffold, PROTEIN ENGINEERING DESIGN & SELECTION, 2016, 第 11 作者(19) Target-Driven Positive Selection at Hot Spots of Scorpion Toxins Uncovers Their Potential in Design of Insecticides, MOLECULAR BIOLOGY AND EVOLUTION, 2016, 第 11 作者(20) A Single-Point Mutation Enhances Dual Functionality of a Scorpion Toxin, COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 2016, 第 11 作者(21) Single-Point Mutation-Mediated Local Amphipathic Adjustment Dramatically Enhances Antibacterial Activity of a Fungal Defensin, FASEB JOURNAL, 2016, 第 11 作者(22) The Drosomycin Multigene Family: Three-Disulfide Variants from Drosophila takahashii Possess Antibacterial Activity, SCIENTIFIC REPORTS, 2016, 第 11 作者(23) 靶向离子通道的神经毒素起源于抗微生物防御肽(英文), 生理学报, 2015, 第 2 作者(24) Mesomartoxin, a New Kv1.2-Selective Scorpion Toxin Interacting with the Channel Selectivity Filter, BIOCHEMICAL PHARMACOLOGY, 2015, 第 11 作者(25) 靶向离子通道的神经毒素起源于抗微生物防御肽, Origin of neurotoxins from defensins, ACTA PHYSIOLOGICA SINICA, 2015, 第 3 作者(26) Target-Driven Evolution of Scorpion Toxins, SCIENTIFIC REPORTS, 2015, 第 11 作者(27) An Insect Defensin-Derived beta-Hairpin Peptide with Enhanced Antibacterial Activity, ACS CHEMICAL BIOLOGY, 2014, 第 11 作者(28) Nrf2/Maf-Binding-Site-Containing Functional Cyp6a2 Allele Is Associated with DDT Resistance in Drosophila melanogaster, PEST MANAGEMENT SCIENCE, 2014, 第 4 作者(29) Characterization of NADPH-Cytochrome P450 Reductase Gene from the Cotton Bollworm, Helicoverpa armigera, GENE, 2014, 第 4 作者(30) Experimental Conversion of a Defensin into a Neurotoxin: Implications for Origin of Toxic Function, MOLECULAR BIOLOGY AND EVOLUTION, 2014, 第 11 作者(31) Fungal Defensins, an Emerging Source of Anti-Infective Drugs, CHINESE SCIENCE BULLETIN, 2014, 第 11 作者(32) Nematode-Derived Drosomycin-Type Antifungal Peptides Provide Evidence for Plant-to-Ecdysozoan Horizontal Transfer of a Disease Resistance Gene, NATURECOMMUNICATIONS, 2014, 第 11 作者(33) Evolutionary origin of beta-defensins, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2013, 第 11 作者(34) Two recombinant alpha-like scorpion toxins from Mesobuthus eupeus with differential affinity toward insect and mammalian Na+ channels, BIOCHIMIE, 2013, 第 11 作者(35) Functional Evolution of Scorpion Venom Peptides with an Inhibitor Cystine Knot Fold, BIOSCIENCE REPORTS, 2013, 第 11 作者(36) Characterization of a chimeric antimicrobial peptide uncovers evolutionary significance of exon-shuffling, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 第 11 作者(37) Dermatophytic defensin with antiinfective potential, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 第 11 作者(38) Comparative genomics analysis of five families of antimicrobial peptide-like genes in seven ant species, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2012, 第 11 作者(39) Alteration of the mode of antibacterial action of a defensin by the amino-terminal loop substitution, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 第 11 作者(40) Evolutionary Diversification of Mesobuthus alpha-Scorpion Toxins Affecting Sodium Channels, MOLECULAR & CELLULAR PROTEOMICS, 2012, 第 11 作者(41) Accelerated evolution and functional divergence of scorpion short-chain K+ channel toxins after speciation, COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 2012, 第 11 作者(42) Evolution of a Neurotoxin from a Defensin, TOXICON, 2012, 第 1 作者(43) Two dyad-free Shaker-type K+ channel blockers from scorpion venom, TOXICON, 2012, 第 11 作者(44) Mutational Analysis of the Analgesic Peptide DrTx(1-42) Revealing a Functional Role of the Amino-Terminal Turn, PLOS ONE, 2012, 第 2 作者(45) Positive selection-guided mutational analysis revealing two key functional sites of scorpion ERG K+ channel toxins, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 第 5 作者(46) Convergent Evolution-Guided Design of Antimicrobial Peptides Derived from Influenza A Virus Hemagglutinin, JOURNAL OF MEDICINAL CHEMISTRY, 2011, 第 11 作者(47) A naturally-occurring carboxyl-terminally truncated alpha-scorpion toxin is a blocker of sodium channels, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 第 11 作者(48) Molecular divergence of two orthologous scorpion toxins affecting potassium channels, COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 2011, 第 11 作者(49) The defensin gene family expansion in the tick Ixodes scapularis, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2011, 第 11 作者(50) Molecular Diversity and Functional Evolution of Scorpion Potassium Channel Toxins, MOLECULAR & CELLULAR PROTEOMICS, 2011, 第 11 作者(51) DrTx(1���42), a C-terminally truncated analogue of drosotoxin, is a candidate of analgesic drugs, BIOCHEMICAL PHARMACOLOGY, 2011, 第 11 作者(52) Convergent Evolution-Guided Design of Antimicrobial Peptides Derived from Influenza A Virus Hemagglutinin, JOURNAL OF MEDICINAL CHEMISTRY, 2011, 第 11 作者(53) Molecular design of new sodium channel blockers, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 第 11 作者(54) DrTx(1���42), a C-terminally truncated analogue of drosotoxin, is a candidate of analgesic drugs, BIOCHEMICAL PHARMACOLOGY, 2011, 第 11 作者(55) Drosotoxin, a selective inhibitor of tetrodotoxin-resistant sodium channels, BIOCHEMICAL PHARMACOLOGY, 2010, 第 11 作者(56) Inhibition of melanization by a Nasonia defensin-like peptide: Implications for host immune suppression, JOURNAL OF INSECT PHYSIOLOGY, 2010, 第 11 作者(57) Functional role of charged residues in drosomycin, a Drosophila antifungal peptide, DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2010, 第 11 作者(58) Inhibition of melanization by a Nasonia defensin-like peptide: Implications for host immune suppression, JOURNAL OF INSECT PHYSIOLOGY, 2010, 第 11 作者(59) Characterization of a hymenoptaecin-like antimicrobial peptide in the parasitic wasp Nasonia vitripennis, PROCESS BIOCHEMISTRY, 2010, 第 11 作者(60) Two recombinant depressant scorpion neurotoxins differentially affecting mammalian sodium channels, TOXICON, 2010, 第 11 作者(61) Antimicrobial peptide-like genes in Nasonia vitripennis: a genomic perspective, BMC GENOMICS, 2010, 第 11 作者(62) Identification and characterization of the parasitic wasp Nasonia defensins: Positive selection targeting the functional region?, DEVELOPMENTALANDCOMPARATIVEIMMUNOLOGY, 2010, 第 11 作者(63) MeuTXK beta 1, a scorpion venom-derived two-domain potassium channel toxin-like peptide with cytolytic activity, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2010, 第 11 作者(64) Characterization of two linear cationic antimalarial peptides in the scorpion Mesobuthus eupeus, BIOCHIMIE, 2010, 第 11 作者(65) A potent potassium channel blocker from Mesobuthus eupeus scorpion venom, BIOCHIMIE, 2010, 第 11 作者(66) A fossil antibacterial peptide gives clues to structural diversity of cathelicidin-derived host defense peptides, FASEB JOURNAL, 2009, 第 11 作者(67) Structural and functional characterization of two genetically related meucin peptides highlights evolutionary divergence and convergence in antimicrobial peptides, FASEB JOURNAL, 2009, 第 11 作者(68) AdDLP, a bacterial defensin-like peptide, exhibits anti-Plasmodium activity, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 第 11 作者(69) Activation of cathepsin L by the cathelin-like domain of protegrin-3, MOLECULAR IMMUNOLOGY, 2008, 第 11 作者(70) Did cathelicidins, a family of multifunctional host-defense peptides, arise from a cysteine protease inhibitor?, TRENDS IN MICROBIOLOGY, 2008, 第 11 作者(71) Discovery of six families of fungal defensin-like peptides provides insights into origin and evolution of the CS alpha beta defensins, MOLECULAR IMMUNOLOGY, 2008, 第 11 作者(72) Gene expression, antiparasitic activity, and functional evolution of the drosomycin family, MOLECULAR IMMUNOLOGY, 2008, 第 11 作者(73) Positively selected sites of scorpion depressant toxins: Possible roles in toxin functional divergence, TOXICON, 2008, 第 11 作者(74) Inducible antibacterial response of scorpion venom gland, PEPTIDES, 2007, 第 11 作者(75) Functional expression of a Drosophila antifungal peptide in Escherichia coli, PROTEIN EXPRESSION AND PURIFICATION, 2007, 第 11 作者(76) 进化基因组学在昆虫天然免疫研究中的应用前景, Evolutionary genomics-based approaches for studies of insect innate immunity, 昆虫知识, 2007, 第 1 作者(77) Evidence for myxobacterial origin of eukaryotic defensins, IMMUNOGENETICS, 2007, 第 11 作者
发表著作
Evolution of Venomous Animals and Their Toxins, Springer Science+Business Media Dordrecht, 2016-06, 第 3 作者
科研活动
科研项目
( 1 ) 孢子霉素的工程化改造, 负责人, 国家任务, 2019-01--2022-12( 2 ) 基于一种新的蝎毒素支架的抗感染分子设计, 负责人, 国家任务, 2016-01--2019-12( 3 ) 应用进化基因组学研究免疫系统发育的关键分子, 负责人, 国家任务, 2010-01--2015-12( 4 ) 动物神经毒素起源的实验室模拟, 负责人, 国家任务, 2008-01--2011-12( 5 ) 寄主-寄生蜂间免疫抑制交互作用的分子机制, 负责人, 国家任务, 2007-07--2009-12
参与会议
(1)Antimicrobial peptides in scorpion venom 国家自然科学基金委国际合作与交流项目会议 2016-01-12(2)A multigene family of Caenorhabditis remanei-specific antifungal peptides with therapeutic potential 中比双边合作项目 高斌 2012-05-25