基本信息
彭景楩  男  博导  中国科学院动物研究所
email: pengjp@ioz.ac.cn
address: 新科祥园9-1708
postalCode: 100010

招生信息

   
招生专业
071008-发育生物学
招生方向
生殖分子免疫学

教育背景

1993-02--1996-01   中国农业大学   理学博士学位
1986-09--1989-08   武汉大学   硕士学位
1978-02--1982-01   湖北大学   学士学位

工作经历

   
工作简历
2001-11~现在, 中科院动物所, 研究员
2000-06~2000-12,Rugters大学, 合作研究
1998-11~2001-11,中国科学院动物研究所, 副研究员
1996-04~1998-10,乔治城大学和Rutgers大学, 博士后
1993-02~1996-01,中国农业大学, 理学博士学位
1989-09~1993-01,湖北大学, 讲师
1986-09~1989-08,武汉大学, 硕士学位
1982-02~1986-07,湖北大学, 助教
1978-02~1982-01,湖北大学, 学士学位

教授课程

生殖生物学
免疫组织化学实验技术
生殖免疫学
医学免疫学
免疫组织化学实验
生殖生理学
组织胚胎学
人体组织胚胎学
免疫组织化学
生殖发育生物学进展

专利与奖励

   
奖励信息
(1) 母胎免疫耐受与排斥(流产)转换的分子机理, 二等奖, 部委级, 2016
(2) 母胎免疫豁免和排斥的分子机理, 一等奖, 部委级, 2011
专利成果
( 1 ) 抗生育重组质粒、基因疫苗及其制备方法和用途, 2010, 第 1 作者, 专利号: 2010101292121

( 2 ) 抗肿瘤重组质粒、基因疫苗及其制备方法和用途, 2010, 第 1 作者, 专利号: 2010101292070

出版信息

   
发表论文
(1) Cytochrome P450 26A1 regulates the clusters and killing activity of NK cells during the peri-implantation period, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2022, 通讯作者
(2) A novel Cytochrome P450 26A1 expressing NK cell subset at the mouse maternal-foetal interface, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2021, 通讯作者
(3) Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period, FRONTIERS IN IMMUNOLOGY, 2021, 通讯作者
(4) Cytochrome P450 26A1 modulates uterine dendritic cells in mice early pregnancy, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2019, 通讯作者
(5) Cytochrome P450 26A1 Modulates Natural Killer Cells in Mouse Early Pregnancy, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2017, 通讯作者
(6) The Balance Between Conventional DCs and Plasmacytoid DCs Is Pivotal for Immunological Tolerance During Pregnancy in the Mouse, SCIENTIFIC REPORTS, 2016, 通讯作者
(7) Seminal Plasma Induces Inflammation in the Uterus Through the γδ T/IL-17 Pathway, Scientific Reports, 2016, 第 9 作者
(8) Seminal plasma induces inflammation in the uterus through the gamma delta T/IL-17 pathway, SCIENTIFIC REPORTS, 2016, 通讯作者
(9) IFN-gamma modulates Ly-49 receptors on NK cells in IFN-gamma-induced pregnancy failure, SCIENTIFIC REPORTS, 2015, 通讯作者
(10) IFN-γ Modulates Ly-49 Receptors on NK Cells in IFN-γ-Induced Pregnancy Failure, Scientific Reports, 2015, 第 6 作者
(11) Regulation of Cyp26A1 on Th17 Cells in Mouse Peri-Implantation, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2014, 通讯作者
(12) High-Dose Interferon-g Promotes Abortion in Mice by Suppressing Treg and Th17 Polarization., J Interf Cytok Res., 2014, 通讯作者
(13) IFN- γ induces aberrant CD49b + NK cell recruitment through regulating CX3CL1: a novel mechanism by which IFN- γ provokes pregnancy failure, Cell Death & Disease, 2014, 
(14) High-Dose Interferon-gamma Promotes Abortion in Mice by Suppressing Treg and Th17 Polarization, JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2014, 通讯作者
(15) Insulin-Like Growth Factor Binding Protein 7 Modulates Estrogen-Induced Trophoblast Proliferation and Invasion in HTR-8 and JEG-3 Cells, CELL BIOCHEMISTRY AND BIOPHYSICS, 2012, 通讯作者
(16) A Novel Role of IGFBP7 in Mouse Uterus: Regulating Uterine Receptivity through Th1/Th2 Lymphocyte Balance and Decidualization, PLOS ONE, 2012, 通讯作者
(17) Retinoic acid synthesis and metabolism are concurrent in the mouse uterus during peri-implantation, CELL AND TISSUE RESEARCH, 2012, 通讯作者
(18) TGF-β1对人蜕膜基质细胞中趋化因子及其受体表达的影响, The Effect of TGF-β1 on Expression of Chemokine and Its Receptor in Human Decidual Stromal Cells, 动物学杂志, 2012, 第 2 作者
(19) The antitumor immunopreventive effects of a DNA vaccine against CYP26a1 on mouse breast carcinoma, VACCINE, 2011, 通讯作者
(20) Estradiol-regulated proline-rich acid protein 1 is repressed by class I histone deacetylase and functions in peri-implantation mouse uterus, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2011, 通讯作者
(21) Estradiol-regulated gene praline-rich acid protein 1 repressed by class I histone deacetylase and its action in peri-implantation mouse uterus, Mol Cell Endocrinol, 2011, 通讯作者
(22) Evidence for the inhibition of fertilization in vitro by anti-ZP3 antisera derived from DNA vaccine, VACCINE, 2011, 通讯作者
(23) Role of secretory protease inhibitor spink3 in mouse uterus during early pregnancy, CELL AND TISSUE RESEARCH, 2010, 通讯作者
(24) Retinoic Acid-Metabolizing Enzyme Cytochrome P450 26a1 (Cyp26a1) Is Essential for Implantation: Functional Study of Its Role in Early Pregnancy, JOURNAL OF CELLULAR PHYSIOLOGY, 2010, 通讯作者
(25) Retinoic acid metabolizing enzyme CYP26A1 is implicated in rat embryo implantation, HUMAN REPRODUCTION, 2010, 通讯作者
(26) Implantation-associated gene-1 (Iag-1): a novel gene involved in the early process of embryonic implantation in rat, HUMAN REPRODUCTION, 2008, 通讯作者
(27) The antifertility effects of DNA vaccine-induced immune responses against uroguanylin, VACCINE, 2008, 通讯作者
(28) 肿瘤细胞侵袭研究进展, Progress in Tumor Cell Invasion, 生理科学进展, 2008, 第 2 作者
(29) Immunogenicity of four complementary deoxyribonucleic acid fragments from rabbit zona pellucida 3 and their effects on fertility, FERTILITY AND STERILITY, 2007, 通讯作者
(30) IFN-gamma promotes apoptosis of the uterus and placenta in pregnant rat and human cytotrophoblast cells, JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2007, 通讯作者
(31) Effect of interferon-gamma treatment on the expression of interleukin-1 beta at the maternal-fetal interface of pregnant rats, REPRODUCTION FERTILITY AND DEVELOPMENT, 2007, 通讯作者
(32) IL-1β对不同妊娠时期大鼠子宫与胎盘 TGF-β1表达的影响, The Effect of IL-1β on TGF-β1 Expression in the Uterus and Placenta at Different Phases of Rat Pregnancy, 动物学杂志, 2006, 第 6 作者
(33) Apoptosis and tumor inhibition induced by human chorionic gonadotropin beta in mouse breast carcinoma, JOURNAL OF MOLECULAR MEDICINE-JMM, 2006, 通讯作者
(34) 干扰素-γ对母胎界面免疫调控的影响, 自然科学进展, 2006, 第 2 作者
(35) Effects of IL-1 beta on RT1-A/RT1-DM at the maternal-fetal interface during pregnancy in rats, FRONTIERS IN BIOSCIENCE-LANDMARK, 2006, 通讯作者
(36) SARS-CoV对幼年和成年布氏田鼠的感染研究, Infection of SARS CoV on juvenile and adult Brandt s Vole Microtus brandtii, 中国实验动物学报, 2005, 第 2 作者
(37) 一种新城疫DNA疫苗及其构建和应用, 科技开发动态, 2005, 第 1 作者
(38) 白细胞介素1β对胚泡植入前后子宫基质金属蛋白酶2(MMP2)表达的影响, Effect of IL-1β on the Expression of MMP2 in Uterus before and after 60Blastocyst Implantation, 动物学杂志, 2005, 第 2 作者
(39) 妊娠大鼠子宫和胎盘中TGF-β1的表达及IFNγ对其表达的影响, The Expression of TGF-β1 in Uterus and Placenta of Pregnant Rat and Its Regulation by IFNγ, 生物化学与生物物理进展, 2005, 第 2 作者
(40) 抗SARS病毒的基因疫苗及其构建和应用, 科技开发动态, 2005, 第 1 作者
(41) 抗SARS病毒的基因疫苗及其制备方法和用途, 科技开发动态, 2005, 第 1 作者
(42) SARS-CoV对幼年和成年布氏田鼠的感染研究, 科学通报, 2005, 第 2 作者
(43) MHCⅡ类分子表达调控的研究进展, 生理科学进展, 2004, 第 2 作者
(44) MHC II类分子表达调控的研究进展, 生理科学进展, 2004, 第 2 作者
(45) 滋养层细胞凋亡调控的研究, Research on the regulation of the apoptosis in trophoblast, 生理科学进展, 2004, 第 2 作者
(46) 卵透明带ZP3的研究及其应用, Studies and Applications of Zona Pellucida 3, 动物学杂志, 2004, 第 2 作者
(47) 白细胞介素-1与生殖活动的神经内分泌免疫调节, 生殖医学杂志, 2003, 第 3 作者
(48) 重组质粒pCR3.1-brZPC’的构建及其体内外表达, 生殖医学杂志, 2003, 第 2 作者
(49) 人绒毛膜促性腺激素β亚基DNA疫苗的构建及其抗肿瘤作用的初步研究, The Construction of Human Chorionic Gonadotropinβ-Subunit Glycoprotein(hCGβ)DNA Vaccine and Its Preliminary Antitumor Study, 生物化学与生物物理进展, 2003, 第 4 作者
(50) pCR3.1—bvLDH-C4′的构建及在体内外的表达, Construction of pCR3.1-bvLDH-C_4~' and Its Expression in Vivo and in Vitro, 动物学杂志, 2003, 第 2 作者
(51) 生物实验数据的两因素方差分析, Two-factor Analysis of Variance on Biological Experimental Data, 动物学杂志, 2003, 第 2 作者
(52) 肿瘤基因疫苗的研究进展, Progress in Genetic Vaccine Against Tumor, 生物化学与生物物理进展, 2003, 第 2 作者
(53) 精子特异性乳酸脱氢酶的免疫学特性及其应用, Immunological Property and Application of Sperm-specific Lactate Dehydrogenase, 动物学杂志, 2002, 第 2 作者
(54) 人重组γ—干扰素对兔妊娠的影响, Influence of hrIFN_γ on rabbit pregnancy, 动物学报, 2002, 第 4 作者

科研活动

   
科研项目
( 1 ) 妊娠建立和维持的免疫调节的分子机理, 参与, 国家任务, 2010-01--2015-12
( 2 ) 子痫前期等重要妊娠相关疾病的分子标志物和诊治策略研究, 参与, 国家任务, 2011-01--2013-12
( 3 ) Cyp26a1调节胚胎植入的信号通路研究, 负责人, 国家任务, 2012-01--2015-12
( 4 ) CYP26A1对妊娠子宫免疫细胞调节作用机制的研究, 负责人, 国家任务, 2016-01--2019-12
( 5 ) 避孕节育及兼有治疗作用的新药具研发, 参与, 国家任务, 2016-01--2019-12