基本信息
刘小龙  男  博导  中国科学院分子细胞科学卓越创新中心
电子邮件: liux@sibcb.ac.cn
通信地址: 上海岳阳路320号
邮政编码: 200031

招生信息

   
招生专业
071009-细胞生物学
100102-免疫学
招生方向
免疫细胞分化与功能

教育背景

1994-09--1999-07   中科院上海生物化学研究所   团委书记/博士
1990-09--1994-07   南昌大学   团总支副书记/学士

工作经历

   
工作简历
2004-10~现在, 中科院上海生科院生化与细胞所, 研究组长
1999-10~2004-09,NCI/NIH, 博士后
1994-09~1999-07,中科院上海生物化学研究所, 团委书记/博士
1990-09~1994-07,南昌大学, 团总支副书记/学士
社会兼职
2015-01-01-今,The Journal of Biological Chemistry, 编辑
2014-08-23-今,中国生物化学与分子生物学会, 副理事长,秘书长
2014-01-01-今,Cellular immunology, 编辑
2010-10-01-今,Cell Research, 编委
2010-01-01-今,Cellular & Molecular Immunology, 编委
2010-01-01-今,Frontiers in Systems Biology, 编辑
2009-01-01-今,Journal of Molecular Cell Biology, 编委
2006-08-01-今,Acta Biochimica et Biophysica Sinica,

教授课程

实验生物学
免疫生物学
肿瘤免疫学
流式细胞分析术的原理与应用

专利与奖励

   
奖励信息
(1) 国家万人计划领军人才, 国家级, 2016
(2) A-IMBN Research Young Investigators Award, , 其他, 2012
(3) 全国优秀博士学位论文指导教师, , 国家级, 2011
(4) 第十一届中国青年科技奖, 一等奖, 国家级, 2010
(5) 国科学院优秀研究生指导教师, 一等奖, 院级, 2010
(6) 中科院****终期考核优秀, 一等奖, 院级, 2008
专利成果
( 1 ) 一种广谱抑制癌细胞生长的蚯蚓蛋白及其编码序列, 2009, 第 1 作者, 专利号: ZL 2005 1 0112490.5

出版信息

   
发表论文
(1) Chromatin assembly factor 1B critically controls the early development but not function acquisition of invariant natural killer T cells in mice., Eur J Immunol., 2021, 通讯作者
(2) Unveiling the heterogeneity of NKT cells in the liver through single cell RNA sequencing., Sci Rep., 2020, 通讯作者
(3) The evolution of zebrafish RAG2 protein is required for adapting to the elevated body temperature of the higher endothermic vertebrates., Sci Rep., 2020, 通讯作者
(4) Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction., Nature, 2019, 其他(合作组作者)
(5) TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity., J Exp Med., 2019, 通讯作者
(6) Th-POK regulates mammary gland lactation through mTOR-SREBP pathway, PLoS Genet., 2018, 第 10 作者
(7) PD-1 Controls Follicular T Helper Cell Positioning and Function, Immunity, 2018, 第 5 作者
(8) Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells, Nat Commun., 2018, 通讯作者
(9) Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23., Nat Commun., 2018, 通讯作者
(10) FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells, Nature, 2018, 其他(合作组作者)
(11) Lis1 Regulates Germinal Center B Cell Antigen Acquisition and Affinity Maturation., J Immunol., 2017, 第 8 作者
(12) Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR+ endosome trafficking, Sci Rep, 2017, 通讯作者
(13) Uhrf1 controls the self-renewal versus differentiation of hematopoietic stem cells by epigenetically regulating the cell-division modes, Proc Natl Acad Sci U S A, 2017, 通讯作者
(14) Dynamic regulation of CD28 conformation and signaling by charged lipids and ions, Nat Struct Mol Biol., 2017, 第 10 作者
(15) Disruption of the RAG2 zinc finger motif impairs protein stability and causes immunodeficiency, Eur J Immunol, 2016, 通讯作者
(16) Uhrf1 controls iNKT cell survival and differentiation through the Akt-mTOR axis, Cell Reports, 2016, 通讯作者
(17) Reconstituted Thymus Organ Culture., Methods Mol Biol., 2016, 通讯作者
(18) RAG1-mediated ubiquitylation of histone H3 is required for chromosomal V(D)J recombination, Cell Res, 2015, 通讯作者
(19) Disruption of the RAG2 zinc finger motif impairs protein stability and causes immunodeficiency, Eur J Immunol, 2015, 通讯作者
(20)  An amphioxus RAG1-like DNA fragment encodes a functional central domain of vertebrate core RAG1., Proc Natl Acad Sci U S A. , 2014, 通讯作者
(21) The mediator subunit Med23 contributes to controlling T-cell activation and prevents autoimmunity., Nat Commun, 2014, 通讯作者
(22) Activator protein 1 suppresses antitumor T-cell function via the induction of programmed death 1.,  Proc Natl Acad Sci U S A., 2012, 通讯作者
(23) LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection, EMBO J, 2011, 通讯作者
(24) p300-Mediated Acetylation Stabilizes the Th-Inducing POK Factor, J Immunol, 2010, 通讯作者
(25) Regulation of Tcrb recombination ordering by c-Fos-dependent RAG deposition, Nat Immunol, 2008, 通讯作者

科研活动

   
科研项目
( 1 ) 国家自然科学国家杰出青年科学基金, 负责人, 国家任务, 2010-01--2013-12
( 2 ) 干扰素调节因子对胸腺细胞定向分化与功能成熟的作用机制, 负责人, 国家任务, 2009-01--2011-12
( 3 ) 始免疫重排机理和形成机制及其比较免疫学研究, 负责人, 国家任务, 2007-07--2011-12
( 4 ) 适应性免疫的起源与演化, 负责人, 国家任务, 2013-01--2017-08
( 5 ) Med23调控T淋巴细胞免疫稳态的机制, 负责人, 国家任务, 2013-01--2016-12
( 6 ) NKT细胞分化成熟的调控机制, 负责人, 国家任务, 2016-01--2020-12
( 7 ) 表观遗传调控因子Uhrf1介导NKT细胞调控肝脏免疫耐受的作用与机制, 负责人, 国家任务, 2016-01--2018-12
( 8 ) 肿瘤免疫学, 负责人, 国家任务, 2017-01--2022-12
( 9 ) NKT细胞亚群分析与功能研究2020.01-2023.12, 负责人, 国家任务, 2020-01--2023-12
( 10 ) 肠道免疫细胞迁移定位与激活分化中的新型蛋白质机2, 参与, 国家任务, 2020-11--2025-10
参与会议
(1)The Mediator Subunit Med23 Prevents Autoimmunity via Setting the T cell Activation Threshold   2015-10-30
(2)The Mediator Subunit Med23 Prevents Autoimmunity via Setting the Threshold for T cell Activation   2015-09-22
(3)Repressing antitumor T cell function by tumor growth   2013-11-01
(4) The serine/threonine kinase LKB1 regulates thymocyte survival and differentiation   2012-03-01
(5)The role of LKB1 in T cell development and function   2011-05-16
(6)The kinase LKB1 controls thymocyte survival and differentiation by regulation of AMPK activation and TCR signal transduction.   2010-11-07
(7)Mechanisms and control of Tcrb recombination ordering and allelic exclusion   2009-10-26
(8)Regulation of Tcrb recombination   2008-10-31
(9) Regulation of Tcrb recombination ordering by c-Fos-dependent RAG deposition   2008-06-26
(10)Creatine kinase B differentially regulates T cell receptor signaling during thymocyte development and T cell function   2007-08-31
(11)CD4-CD8 lineage decision of MHC II-signaled thymocytes   2006-07-16
(12)The Mechanism of thymocyte positive selection regulated by TCR signals   2005-06-13