100706-药理学

糖尿病及代谢性疾病药理学

1996-09--1999-07   中国科学院上海药物研究所   博士

   

2005-07~现在, 中国科学院上海药物研究所, 研究组长，研究员
2002-10~2004-01,瑞典Karolinska 研究所, 博士后
2002-03~2005-06,中国科学院上海药物研究所, 研究组长，副研究员
1999-07~2002-03,中国科学院上海药物研究所, 助理研究员
1996-09~1999-07,中国科学院上海药物研究所, 博士

高等药理学糖尿病药理

   

（ 1 ） 甲状腺素受体β 选择性激动剂化合物、其药物组合物和用途(PCT), 2022, 第 2 作者, 专利号: WO2022127699A1

（ 2 ） 甲状腺素受体β 选择性激动剂化合物、其药物组合物和用途, 2022, 第 2 作者, 专利号: CN114634486A

（ 3 ） 醚类化合物及其在防治糖尿病及代谢综合征中的药学用途, 2021, 第 2 作者, 专利号: CN113149941A

（ 4 ） 酯类化合物及其制备方法和应用、酯类软药, 2021, 第 2 作者, 专利号: CN112794844A

（ 5 ） 一种七元环化合物及在防治糖尿病及代谢综合征中的应用, 2020, 第 2 作者, 专利号: CN111196816A

（ 6 ） 一类酰胺结构的GPR40激动剂化合物及其用途, 2019, 第 2 作者, 专利号: CN109666027A

（ 7 ） 一种含吡嗪环链接的苯丙酸类化合物、其药物组合物、制备方法和用途, 2018, 第 2 作者, 专利号: CN107556252A

（ 8 ） 呋喃卡山烷二萜衍生物及其药物组合物和其在制药中的应用, 2017, 第 2 作者, 专利号: CN106810563A

（ 9 ） 酰胺类化合物及其制备方法、药物组合物和用途, 2015, 第 2 作者, 专利号: CN105164112A

（ 10 ） 一类山酮串色酮类化合物及其制备方法和用途, 2015, 第 2 作者, 专利号: CN104945389A

（ 11 ） 一种含氮杂环链接的苯丙酸类化合物、其药物组合物、制备方法和用途, 2014, 第 2 作者, 专利号: CN104109115A

（ 12 ） 五元唑类杂环化合物及其制备方法、药物组合物和用途, 2014, 第 2 作者, 专利号: CN103864754A

（ 13 ） 氮(氧)杂环戊烷-2-酮(硫酮)类化合物、其药物组合物、制备方法和用途, 2014, 第 2 作者, 专利号: CN103626713A

（ 14 ） 芳香氧基嘧啶甲酰胺或芳香氧基吡啶甲酰胺类化合物及其制备方法、药物组合物和用途, 2013, 第 1 作者, 专利号: CN102850321A

（ 15 ） 酰胺类化合物及其制备方法、组合物和用途, 2012, 第 2 作者, 专利号: CN102584741A

（ 16 ） 二氢呋喃-2-酮类化合物在制备抗糖尿病及糖脂代谢药物中的用途, 2012, 第 1 作者, 专利号: CN102451178A

（ 17 ） 芳基甲酰胺类化合物及其制备方法、药物组合物和用途, 2011, 第 2 作者, 专利号: CN102219759A

（ 18 ） 一类取代的丙酰胺类化合物、其制备方法及用途, 2011, 第 2 作者, 专利号: CN102146078A

（ 19 ） 七元环化合物及其在防治糖尿病及代谢综合征中的药学用途, 2010, 第 2 作者, 专利号: CN101687886A

（ 20 ） 2－芳基－3－(四氢－2H－吡喃－4－基)－N－芳杂环基－丙酰胺类化合物、其药物组合物及用途, 2010, 第 2 作者, 专利号: CN101659661A

（ 21 ） 葫芦烷型三萜皂苷化合物、其药物组合物及其制备方法和用途, 2009, 第 3 作者, 专利号: CN101450963A

（ 22 ） 一类嘧啶取代苯丙酸化合物在制备预防和/或治疗糖尿病药物中的用途, 2009, 第 2 作者, 专利号: CN101411704A

（ 23 ） 新型大环多聚二硫醚化合物木榄环六硫醇的合成方法, 2008, 第 6 作者, 专利号: CN101210010A

（ 24 ） 木榄环六硫醇类化合物及其制备方法和用途, 2006, 第 4 作者, 专利号: CN1861595A

（ 25 ） 从凤尾草中分离洋芹子素衍生物及它们的用途, 2006, 第 5 作者, 专利号: CN1837226A

   

（1） TGR5 agonist inhibits intestinal epithelial cell apoptosis via cAMP/PKA/c-FLIP/JNK signaling pathway and ameliorates dextran sulfate sodium-induced ulcerative colitis., ACTA PHARMACOLOGICA SINICA, 2023, 
（2） Phenotypic screening-based drug discovery of furan-2-carboxylic acid derivatives for the amelioration of type 2 diabetes mellitus (T2DM), Eur J Med Chem, 2023, 
（3） Coronarin A modulated hepatic glycogen synthesis and gluconeogenesis via inhibiting mTORC1/S6K1 signaling and ameliorated glucose homeostasis of diabetic mice, ACTA PHARMACOLOGICA SINICA, 2023, 第 11 作者
（4） Discovery of Highly Potent and Selective Thyroid Hormone Receptor �� Agonists for the Treatment of Nonalcoholic Steatohepatitis, Journal of Medicinal Chemistry, 2023, 第 11 作者
（5） Alisol B Alleviates Hepatocyte Lipid Accumulation and Lipotoxicity via Regulating RAR��-PPAR��-CD36 Cascade and Attenuates Non-Alcoholic Steatohepatitis in Mice, NUTRIENTS, 2022, 第 11 作者
（6） Development and structure-activity relationships of tanshinones as selective 11��-hydroxysteroid dehydrogenase 1 inhibitors, NATURAL PRODUCTS AND BIOPROSPECTING, 2022, 第 11 作者
（7） Design, synthesis and structural-activity relationship studies of phanginin A derivatives for regulating SIK1-cAMP/CREB signaling to suppress hepatic gluconeogenesis, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 第 11 作者
（8） Design and exploration of gut-restricted bifunctional molecule with TGR5 agonistic and DPP4 inhibitory effects for treating ulcerative colitis, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 第 11 作者
（9） Phytochemicals from the Leaves of Cyclocarya paliurus and their 11 beta-HSD1 Enzyme Inhibitory Effects, CHEMISTRY & BIODIVERSITY, 2021, 第 5 作者
（10） A new mechanism of obeticholic acid on NASH treatment by inhibiting NLRP3 inflammasome activation in macrophage, METABOLISM-CLINICAL AND EXPERIMENTAL, 2021, 第 11 作者
（11） Design of G-protein-coupled bile acid receptor 1 (GPBAR1, TGR5) soft drugs with reduced gallbladder-filling effects, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 第 11 作者
（12） Discovery of Highly Polar beta-Homophenylalanine Derivatives as Nonsystemic Intestine-Targeted Dipeptidyl Peptidase IV Inhibitors, JOURNAL OF MEDICINAL CHEMISTRY, 2019, 第 11 作者
（13） TGR5 agonist ameliorates insulin resistance in skeletal muscles and improves glucose homeostasis in diabetic mice, METABOLISM-CLINICAL AND EXPERIMENTAL, 2019, 第 11 作者
（14） Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3, FRONTIERS IN PHARMACOLOGY, 2018, 第 11 作者
（15） Structural Elucidation and Bioinspired Total Syntheses of Ascorbylated Diterpenoid Hongkonoids A-D, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 第 9 作者
（16） Synthesis of selective 11��-HSD1 inhibitors based on dammarane scaffold, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 第 5 作者
（17） Design and synthesis of Atglistatin derivatives as adipose triglyceride lipase inhibitors, CHEMICAL BIOLOGY & DRUG DESIGN, 2017, 第 11 作者
（18） Deheiculatins A-L, 20-oxygenated cembranoids from Macaranga deheiculata, PHYTOCHEMISTRY, 2017, 第 4 作者
（19） Downregulation of lipin-1 induces insulin resistance by increasing intracellular ceramide accumulation in C2C12 myotubes, INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2017, 第 11 作者
（20） Synthesis of selective 11 beta-HSD1 inhibitors based on dammarane scaffold, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 第 11 作者
（21） 16-nor Limonoids from Harrisonia perforata as promising selective 11 beta-HSD1 inhibitors, SCIENTIFIC REPORTS, 2016, 第 8 作者
（22） Synthesis of hupehenols A, B, and E from protopanaxadiol, RSC ADVANCES, 2016, 第 9 作者
（23） OL3, a novel low-absorbed TGR5 agonist with reduced side effects, lowered blood glucose via dual actions on TGR5 activation and DPP-4 inhibition, OL3, a novel low-absorbed TGR5 agonist with reduced side effects, lowered blood glucose via dual actions on TGR5 activation and DPP-4 inhibition, 中国药理学报：英文版, 2016, 第 7 作者
（24） Analysis of diacylglycerols by ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry: Double bond location and isomers separation, ANALYTICA CHIMICA ACTA, 2016, 第 6 作者
（25） OL3, a novel low-absorbed TGR5 agonist with reduced side effects, lowered blood glucose via dual actions on TGR5 activation and DPP-4 inhibition, OL3, a novel low-absorbed TGR5 agonist with reduced side effects, lowered blood glucose via dual actions on TGR5 activation and DPP-4 inhibition, ACTA PHARMACOLOGICA SINICA, 2016, 第 11 作者
（26） Intestinally-targeted TGR5 agonists equipped with quaternary ammonium have an improved hypoglycemic effect and reduced gallbladder filling effect, SCIENTIFIC REPORTS, 2016, 第 11 作者
（27） Discovery and Structure-Activity Relationship Study of 4-Phenoxythiazol-5-carboxamides as Highly Potent TGR5 Agonists, CHEMICAL & PHARMACEUTICAL BULLETIN, 2016, 第 11 作者
（28） Limonoids and Triterpenoids as 11 beta-HSD1 Inhibitors from Walsura robusta, JOURNAL OF NATURAL PRODUCTS, 2016, 第 4 作者
（29） Design and Synthesis of Novel Arctigenin Analoguesfor the Amelioration of Metabolic Disorders, ACS MEDICINAL CHEMISTRY LETTERS, 2015, 第 8 作者
（30） Yhhu4488, a novel GPR40 agonist, promotes GLP-1 secretion and exerts anti-diabetic effect in rodent models, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 第 11 作者
（31） HC toxin (a HDAC inhibitor) enhances IRS1-Akt signalling and metabolism in mouse myotubes, JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2015, 第 4 作者
（32） Hupehenols A-E, Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD1) Inhibitors from Viburnum hupehense, JOURNAL OF NATURAL PRODUCTS, 2015, 第 0 作者
（33） AICAR and Metformin Exert AMPK-dependent Effects on INS-1E Pancreatic ��-cell Apoptosis via Differential Downstream Mechanisms, INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2015, 第 3 作者
（34） Ricinodols A-G: new tetracyclic triterpenoids as 11 beta-HSD1 inhibitors from Ricinodendron heudelotii, RSC ADVANCES, 2015, 第 4 作者
（35） 8. Zhou B, Shen Y, Wu Y, Leng Y*, Yue JM*.Limonoids with 11��-Hydroxysteroid Dehydrogenase Type 1 Inhibitory Activities from Dysoxylum mollissimum., J Nat Prod., 2015, 第 11 作者
（36） Limonoids with 11 beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitory Activities from Dysoxylum mollissimum, JOURNAL OF NATURAL PRODUCTS, 2015, 第 4 作者
（37） AICAR and Metformin Exert AMPK-dependent Effects on INS-1E Pancreatic beta-cell Apoptosis via Differential Downstream Mechanisms, INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2015, 第 11 作者
（38） Yhhu981, a novel compound, stimulates fatty acid oxidation via the activation of AMPK and ameliorates lipid metabolism disorder in ob/ob mice, Yhhu981, a novel compound, stimulates fatty acid oxidation via the activation of AMPK and ameliorates lipid metabolism disorder in ob/ob mice, 中国药理学报：英文版, 2015, 
（39） Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes, JOURNAL OF MEDICINAL CHEMISTRY, 2015, 第 11 作者
（40） Yhhu981,a novel compound,stimulates fatty acid oxidation via the activation of AMPK and ameliorates lipid metabolism disorder in ob/ob mice, ACTAPHARMACOLOGICASINICA, 2015, 第 6 作者
（41） Dammarane-type triterpenoids as 11 beta-HSD1 inhibitors from Homonoia riparia, ORGANIC & BIOMOLECULAR CHEMISTRY, 2014, 第 4 作者
（42） New rearranged limonoids from Walsura cochinchinensis, RSC ADVANCES, 2014, 第 3 作者
（43） Lithocarpic acids O���S, five homo-cycloartane derivatives from the cupules of Lithocarpus polystachyus, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 第 11 作者
（44） Ingol-Type Diterpenes from Euphorbia antiquorum with Mouse 11 beta-Hydroxysteroid Dehydrogenase Type 1 Inhibition Activity, JOURNAL OF NATURAL PRODUCTS, 2014, 第 4 作者
（45） Lithocarpic Acids A-N, 3,4-seco-Cycloartane Derivatives from the Cupules of Lithocarpus polystachyus, JOURNAL OF NATURAL PRODUCTS, 2014, 第 11 作者
（46） SHR3824, a novel selective inhibitor of renal sodium glucose cotransporter 2, exhibits antidiabetic efficacy in rodent models, ACTA PHARMACOLOGICA SINICA, 2014, 第 11 作者
（47） 4-Benzofuranyloxynicotinamide derivatives are novel potent and orally available TGR5 agonists, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 第 11 作者
（48） Further cycloartane and friedelane triterpenoids from the leaves of Caloncoba glauca, PHYTOCHEMISTRY LETTERS, 2014, 第 4 作者
（49） Synthesis and biological evaluation of pyrrolidine-2-carbonitrile and 4-fluoropyrrolidine-2-carbonitrile derivatives as dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes, BIOORGANICMEDICINALCHEMISTRY, 2013, 第 11 作者
（50） 11 beta-HSD1 Inhibitors from Walsura cochinchinensis, JOURNAL OF NATURAL PRODUCTS, 2013, 第 4 作者
（51） Discovery and structure���activity relationships of ent-Kaurene diterpenoids as potent and selective 11��-HSD1 inhibitors: Potential impact in diabetes, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 第 7 作者
（52） Design, Synthesis, and Structure-Activity Relationships of 3,4,5-Trisubstituted 4,5-Dihydro-1,2,4-oxadiazoles as TGR5 Agonists, CHEMMEDCHEM, 2013, 第 11 作者
（53） Design, synthesis and biological evaluation of a novel class of potent TGR5 agonists based on a 4-phenyl pyridine scaffold, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 第 11 作者
（54） Guanidine Alkaloids from Plumbago zeylanica, JOURNAL OF NATURAL PRODUCTS, 2013, 第 7 作者
（55） Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11 beta-HSD1 inhibitors: Potential impact in diabetes, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 第 7 作者
（56） Pseudoferic acids A���C, three novel triterpenoids from the root bark of Pseudolarix kaempferi, TETRAHEDRON LETTERS, 2012, 第 9 作者
（57） Acute and chronic administration of SHR117887, a novel and specific dipeptidyl peptidase-4 inhibitor, improves metabolic control in diabetic rodent models, ACTA PHARMACOLOGICA SINICA, 2012, 第 11 作者
（58） Acute and chronic administration of SHRl17887, a novel and specific dipeptidyl peptidase-4 inhibitor, improves metabolic control in diabetic rodent models, Acute and chronic administration of SHRl17887, a novel and specific dipeptidyl peptidase-4 inhibitor, improves metabolic control in diabetic rodent models, 中国药理学报：英文版, 2012, 第 7 作者
（59） Cycloartane and Friedelane Triterpenoids from the Leaves of Caloncoba glauca and Their Evaluation for Inhibition of 11��-Hydroxysteroid Dehydrogenases., J Nat Prod., 2012, 第 11 作者
（60） Conosilane A, an Unprecedented Sesquiterpene from the Cultures of Basidiomycete Conocybe siliginea, ORGANIC LETTERS, 2012, 第 6 作者
（61） Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice, DIABETOLOGIA, 2012, 
（62） Emodin, an 11 beta-hydroxysteroid dehydrogenase type 1 inhibitor, regulates adipocyte function in vitro and exerts anti-diabetic effect in ob/ob mice, ACTA PHARMACOLOGICA SINICA, 2012, 第 11 作者
（63） Emodin, an 11β-hydroxysteroid dehydrogenase type I inhibitor, regulates adipocyte function in vitro and exerts anti-diabetic effect in ob/ob mice, Emodin, an 11��-hydroxysteroid dehydrogenase type I inhibitor, regulates adipocyte function in vitro and exerts anti-diabetic effect in ob/ob mice, 中国药理学报：英文版, 2012, 
（64） Cycloartane and Friedelane Triterpenoids from the Leaves of Caloncoba glauca and Their Evaluation for Inhibition of 11 beta-Hydroxysteroid Dehydrogenases, JOURNAL OF NATURAL PRODUCTS, 2012, 第 11 作者
（65） Pseudoferic acids A���C, three novel triterpenoids from the root bark of Pseudolarix kaempferi, TETRAHEDRON LETTERS, 2012, 第 9 作者
（66） Design, synthesis, and pharmacological evaluation of benzamide derivatives as glucokinase activators, BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 第 11 作者
（67） Synthesis and evaluation of piperidine urea derivatives as efficacious 11 beta-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 第 11 作者
（68） Emodin, an 11��-hydroxysteroid dehydrogenase type 1 inhibitor, regulates adipocyte function in vitro and exerts anti-diabetic effect in ob/ob mice, ACTA PHARMACOLOGICA SINICA, 2012, 第 5 作者
（69） Synthesis and evaluation of piperidine urea derivatives as efficacious 11��-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 第 5 作者
（70） Discovery of novel dual-action antidiabetic agents that inhibit glycogen phosphorylase and activate glucokinase, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 第 11 作者
（71） Cyclopeptide Alkaloids from Ziziphus apetala, JOURNAL OF NATURAL PRODUCTS, 2011, 第 5 作者
（72） Chemical Constituents and Their Bioactivities of "Tongling White Ginger" (Zingiber officinale), JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2011, 第 6 作者
（73） N-(5-substituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl) propanamides as glucokinase activators, MEDCHEMCOMM, 2011, 第 11 作者
（74） Synthesis and biological evaluation of azobicyclo3.3.0 octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 第 17 作者
（75） Rare merosesquiterpenoids from basidiomycete Craterellus odoratus and their inhibition of 11 beta-hydroxysteroid dehydrogenases, PHYTOCHEMISTRY, 2010, 第 11 作者
（76） Desgin, synthesis, and pharmacological evaluation of N-(4-mono and 4,5-disubstituted thiazol-2-yl)- 2-aryl-3-(tetrahydro-2H-pyran-4-yl) propanamides as glucokinase activators., Bioorg Med Chem, 2010, 第 11 作者
（77） Synthesis and biological evaluation of bicyclo3.3.0 octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 第 10 作者
（78） Emodin, a natural product, selectively inhibits 11 beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice, BRITISH JOURNAL OF PHARMACOLOGY, 2010, 第 11 作者
（79） Vibralactones D-F from Cultures of the Basidiomycete Boreostereum vibrans, CHEMICAL & PHARMACEUTICAL BULLETIN, 2010, 第 5 作者
（80） Kansuinone, a novel euphane-type triterpene from Euphorbia kansui, TETRAHEDRON LETTERS, 2010, 第 7 作者
（81） Emodin, a natural product, selectively inhibits 11��-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice, BRITISH JOURNAL OF PHARMACOLOGY, 2010, 第 8 作者
（82） Discovery of novel dual functional agent as PPAR gamma agonist and 11 beta-HSD1 inhibitor for the treatment of diabetes, BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 第 9 作者
（83） Derivatives of (phenylsulfonamido-methyl)nicotine and (phenylsulfonamido-methyl)thiazole as novel 11 beta-hydroxysteroid dehydrogenase type 1 inhibitors: synthesis and biological activities in vitro, ACTA PHARMACOLOGICA SINICA, 2009, 第 11 作者
（84） Pentanol derivatives from basidiomycete Catathelasma imperiale and their 11 beta-hydroxysteroid dehydrogenases inhibitory activity, JOURNAL OF ANTIBIOTICS, 2009, 第 5 作者
（85） 4-(Phenylsulfonamidomethyl) benzamides as potent and selective inhibitors of the 11 beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 第 11 作者
（86） Derivatives of (phenylsulfonamido-methyl)nicotine and (phenylsulfonamido-methyl)thiazole as novel 11β-hydroxysteroid dehydrogenase type 1 inhibitors: synthesis and biological activities in vitro, Derivatives of (phenylsulfonamido-methyl)nicotine and (phenylsulfonamido-methyl)thiazole as novel 11��-hydroxysteroid dehydrogenase type 1 inhibitors: synthesis and biological activities in vitro, 中国药理学报：英文版, 2009, 第 6 作者
（87） Sesquiterpenes from Cultures of the Basidiomycete Clitocybe conglobata and Their 11 beta-Hydroxysteroid Dehydrogenase Inhibitory Activity, CHEMICAL & PHARMACEUTICAL BULLETIN, 2009, 第 11 作者
（88） Structure-based virtual screening for identification of novel 11 beta-HSD1 inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 第 11 作者
（89） Benzamide derivatives as dual-action hypoglycemic agents that inhibit glycogen phosphorylase and activate glucokinase, BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 第 6 作者
（90） Discovery of novel inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 by docking and pharmacophore modeling, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 第 11 作者
（91） Downregulation of Diacylglycerol Kinase Delta Contributes to Hyperglycemia-Induced Insulin Resistance, CELL, 2008, 第 2 作者
（92） Role of AMP kinase and PPAR delta in the regulation of lipid and glucose metabolism in human skeletal muscle, JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 第 4 作者
（93） Effect of a novel non-thiazolidinedione peroxisome proliferator-activated receptor a/g agnonist on glucose uptake., Diabetologia, 2007, 第 11 作者
（94） Antidiabetic effect of a novel non-thiazolidinedione PPAR gamma/alpha agonist on ob/ob mice, ACTA PHARMACOLOGICA SINICA, 2006, 第 11 作者
（95） Antidiabetic effect of a novel non-thiazolidinedione PPAR ��/�� agonist on ob/ob mice, ACTA PHARMACOLOGICA SINICA, 2006, 第 7 作者
（96） Anti-implantation effect of droloxifene in rats and its relationship with anti-estrogenic activity, ACTA PHARMACOLOGICA SINICA, 2005, 
（97） 大鼠妊娠早期血清雌、孕激素水平的变化以及屈洛昔芬对妊娠大鼠的抗着床作用, 发育与生殖生物学报：英文版, 2001, 第 2 作者
（98） 双炔失碳酯、屈洛昔芬、诺美孕酮及米非司酮对离体培养大鼠黄体细胞凋亡的影响（英文）, ACTA PHARMACOLOGICA SINICA, 1999, 第 1 作者
（99） 双炔失碳酯，屈洛昔芬，诺美孕酮及米非司酮对离体培养大鼠黄体细胞 …, 中国药理学报, 1999, 第 1 作者
（100） 双炔失碳酯屈洛昔芬诺美孕酮及米非司酮对离体培养大鼠黄体细胞凋亡的影响, ACTAPHARMACOLOGICASINICA, 1999, 第 4 作者
（101） 屈洛昔芬对妊娠大鼠黄体细胞凋亡的诱导作用及其机理研究, 1999, 第 1 作者
（102） 黄体退化中细胞凋亡的调控研究, 生殖与避孕, 1999, 第 1 作者
（103） Activation of SIK1 by phanginin A inhibits hepatic gluconeogenesis by increasing PDE4 activity and suppressing cAMP signaling pathway, MOLECULAR METABOLISM, 第 7 作者

   

（ 1 ） 应用GalNAc肝靶向技术开发NASH疾病的治疗药物, 参与, 地方任务, 2023-07--2024-12
（ 2 ） 泽泻醇B治疗非酒精性脂肪性肝炎功能发现 和机制研究, 负责人, 研究所自主部署, 2022-05--2024-05
（ 3 ） 治疗非酒精性脂肪性肝炎活性化合物发现和候选新药研究, 负责人, 研究所自主部署, 2021-04--2023-04
（ 4 ） TGR5激动剂对炎症性肠病的治疗作用及其机制研究, 负责人, 国家任务, 2019-01--2022-12
（ 5 ） Fwo-1系列化合物的抗糖尿病候选新药研究, 参与, 国家任务, 2018-01--2020-12
（ 6 ） 抗糖尿病新药临床前药效学研究, 负责人, 境内委托项目, 2016-03--2017-12
（ 7 ） TGR5激动剂类抗糖尿病先导化合物个性化特征研究, 负责人, 中国科学院计划, 2016-01--2017-12
（ 8 ） 抗糖尿病活性先导化合物发现, 负责人, 其他国际合作项目, 2014-11--2017-11
（ 9 ） lipin-1 和DGKδ共调控骨骼肌糖脂代谢和胰岛素敏感性, 负责人, 国家任务, 2013-01--2016-12
（ 10 ） 基于TGR5激动剂的抗糖尿病候选新药研究, 负责人, 国家任务, 2012-01--2015-12
（ 11 ） 抗糖尿病新药研究, 负责人, 其他国际合作项目, 2009-04--2013-09
（ 12 ） 治疗糖尿病及代谢性疾病活性物质的筛选和机制研究, 负责人, 国家任务, 2009-01--2013-12
（ 13 ） 抗糖尿病天然化合物DC250188对胰岛素和AMPK信号转导通路的新型调控作用及构效关系研究, 负责人, 国家任务, 2009-01--2011-12
（ 14 ） 大黄素类化合物作为选择性11beta-羟类固醇脱氢酶抑制剂的发现及其抗糖尿病作用研究, 负责人, 国家任务, 2009-01--2011-12