基本信息
李宾  女  博导  中国科学院上海应用物理研究所
email: libin@sari.ac.cn
address: 上海嘉定嘉罗公路201800
postalCode: 201800

招生信息

   
招生专业
070301-无机化学
071011-生物物理学
0710J1-纳米科学与技术
招生方向
单分子反应
DNA纳米技术

专利与奖励

   
专利成果
( 1 ) 一种高通量单分子力谱方法, 2021, 第 1 作者, 专利号: 201811400595.4

( 2 ) 单个生物分子反应实时原位表征方法, 2013, 第 2 作者, 专利号: CN102252954

( 3 ) 一种涉及DNA折纸的方法及其结构和应用, 2013, 第 2 作者, 专利号: 102559891

出版信息

   
发表论文
(1) Nanomechanical Induction of Autophagy-Related Fluorescence in Single Cells with Atomic Force Microscopy, ADVANCED SCIENCE, 2021, 第 1 作者
(2) Response of Escherichia coli to hydrogen nanobubbles: an in vitro evaluation using synchrotron infrared spectroscopy, Journal of Zhejiang University. Science. B, 2021, 通讯作者
(3) Cytoskeleton induced the changes of microvilli and mechanical properties in living cells by atomic force microscopy, JOURNAL OF CELLULAR PHYSIOLOGY, 2021, 通讯作者
(4) Spatial high resolution of actin filament organization by PeakForce atomic force microscopy, CELL PROLIFERATION, 2020, 通讯作者
(5) Label-Free and Three-Dimensional Visualization Reveals the Dynamics of Plasma Membrane-Derived Extracellular Vesicles, NANO LETTERS, 2020, 通讯作者
(6) Capturing transient antibody conformations with DNA origami epitopes, NATURE COMMUNICATIONS, 2020, 通讯作者
(7) Unconventional Atomic Structure of Graphene Sheets on Solid Substrates, SMALL, 2019, 其他(合作组作者)
(8) Mechanical Stress-Dependent Autophagy Component Release via Extracellular Nanovesicles in Tumor Cells, ACS NANO, 2019, 通讯作者
(9) Effect of concentration and adsorption time on the formation of a large-scale origami pattern, Effect of concentration and adsorption time on the formation of a large-scale origami pattern, 核技术:英文版, 2019, 第 8 作者
(10) Starvation effect on the morphology of microvilli in HeLa cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 通讯作者
(11) Quantitative Measurement of Spatial Effects of DNA Origami on Molecular Binding Reactions Detected using Atomic Force Microscopy, ACS APPLIED MATERIALS & INTERFACES, 2019, 通讯作者
(12) Effect of concentration and adsorption time on the formation of a large-scale origami pattern, NUCLEAR SCIENCE AND TECHNIQUES, 2019, 通讯作者
(13) Atomic force microscopy-based single-molecule force spectroscopy detects DNA base mismatches, NANOSCALE, 2019, 通讯作者
(14) Dalian Extreme Ultraviolet Coherent Light Source, CHINESE JOURNAL OF LASERS-ZHONGGUO JIGUANG, 2019, 第 53 作者
(15) Fifteen years of Servitude et Grandeur to the application of a biophysical technique in medicine: The tale of AFMBioMed, JOURNAL OF MOLECULAR RECOGNITION, 2019, 第 8 作者
(16) 基于DNA折纸的单个链霉亲和素分子的原子力显微术高分辨成像, High-resolution imaging of single-molecule streptavidin using atomic force microscopy based on DNA origami, 核技术, 2019, 第 5 作者
(17) 氧化石墨烯纳米片对淀粉样蛋白纤维的影响, The effect of graphene oxide nanosheets on the dissociation of amyloid fibers, 核技术, 2019, 第 5 作者
(18) Characterization of Cell Membrane using Atomic Force Microscopy, BIOPHYSICAL JOURNAL, 2019, 第 6 作者
(19) Measurement of nanomechanical properties of DNA molecules by PeakForce atomic force microscopy based on DNA origami, NANOSCALE, 2019, 通讯作者
(20) 大连极紫外相干光源, Dalian Extreme Ultraviolet Coherent Light Source, 中国激光, 2019, 第 53 作者
(21) 一种新型keV波段超高分辨光栅光谱仪设计, Design of Novel KeV-Range Grating Spectrometer with Ultra-High Resolving Power, 光学学报, 2019, 通讯作者
(22) One-step ion beam irradiation manufacture of 3D micro/nanopatterned structures in SiC with tunable work functions, CARBON, 2019, 第 10 作者
(23) Nanoscale mapping of dielectric properties based on surface adhesion force measurements, BEILSTEIN JOURNAL OF NANOTECHNOLOGY, 2018, 第 5 作者
(24) 单分子荧光共振能量转移用于生物大分子构象动态变化过程研究进展, Progresses of Single Molecular Fluorescence Resonance Energy Transfer in Studying Biomacromolecule Dynamic Process, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2018, 第 6 作者
(25) 基于超快动力学模型的阿秒脉冲复原方法, Reconstruction Method of Attosecond Pulses Based on Ultrafast Dynamic Model, 光学学报, 2018, 通讯作者
(26) Nanomanipulation of Individual DNA Molecules Covered by Single-Layered Reduced Graphene Oxide Sheets on a Solid Substrate, JOURNAL OF PHYSICAL CHEMISTRY B, 2018, 第 3 作者
(27) A sagittally confined high-resolution spectrometer in the 'water window', JOURNAL OF SYNCHROTRON RADIATION, 2018, 通讯作者
(28) 水窗段弧矢增强型高分辨谱仪, Journal of Synchrotron Radiation, 2018, 通讯作者
(29) 单分子荧光共振能量转移用于生物大分子构象动态变化过程研究进展, Progresses of Single Molecular Fluorescence Resonance Energy Transfer in Studying Biomacromolecule Dynamic Process, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2018, 第 6 作者
(30) 个性化角膜屈光手术建模及对于散光修正能力的分析, Laser & Optoelectronics Progress, 2017, 通讯作者
(31) 一种新型太赫兹光源及色散原理, New Journal of Physics, 2017, 通讯作者
(32) Chromatic effect in a novel THz generation scheme, NEW JOURNAL OF PHYSICS, 2017, 通讯作者
(33) The mechanism of the interaction between curcumin and bovine serum albumin using fluorescence spectrum, RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY B, 2017, 第 6 作者
(34) The effect of aluminum of human islet amyioid ion on the aggregation polypeptide (11-28), The effect of aluminum of human islet amyioid ion on the aggregation polypeptide (11-28), 生物化学与生物物理学报:英文版, 2017, 第 8 作者
(35) The effect of aluminum ion on the aggregation of human islet amyloid polypeptide (11-28), ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2017, 通讯作者
(36) 个性化人眼模型及屈光手术视觉质量评估, 核技术, 2017, 通讯作者
(37) Interfacial nanobubbles produced by long-time preserved cold water, CHINESE PHYSICS B, 2017, 第 6 作者
(38) Size-Dependent Stiffness of Nanodroplets: A Quantitative Analysis of the Interaction between an AFM Probe and Nanodroplets, LANGMUIR, 2016, 第 8 作者
(39) Adsorption behavior of magnetite nanoparticles into the DPPC model membranes, APPLIED SURFACE SCIENCE, 2016, 第 7 作者
(40) Acupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain, SCIENTIFIC REPORTS, 2016, 第 8 作者
(41) High Resolution Imaging of Single-Molecule Immunoglobulin G Antibodies with Atomic Force Microscopy in Liquid, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2016, 通讯作者
(42) Palladium nanoparticles supported by amyloid fibrils: From size controllable synthesis to extremely high catalytic performance, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2015, 第 6 作者
(43) Tunable Binding Reactions on DNA Origami Nanostructures, BIOPHYSICAL JOURNAL, 2014, 第 1 作者
(44) 基于DNA折纸的DNA复制的单分子检测和表征, 南方医科大学学报, 2014, 第 3 作者
(45) Selective synthesis of clinoatacamite Cu-2(OH)(3)Cl and tenorite CuO nanoparticles by pH control, JOURNAL OF NANOPARTICLE RESEARCH, 2014, 第 6 作者
(46) GInR Negatively Regulates the Transcription of the Alanine Dehydrogenase Encoding Gene ald in Amycolatopsis mediterranei U32 under Nitrogen Limited Conditions via Specific Binding to Its Major Transcription Initiation Site, PLOS ONE, 2014, 第 4 作者
(47) Experimental Demonstration of Longitudinal Beam Phase-Space Linearizer in a Free-Electron Laser Facility by Corrugated Structures, PHYSICAL REVIEW LETTERS, 2014, 其他(合作组作者)
(48) Hierarchical ordering of amyloid fibrils on the mica surface, NANOSCALE, 2013, 第 8 作者
(49) Molecular Threading and Tunable Molecular Recognition on DNA Origami Nanostructures, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 第 10 作者
(50) Probing tethered targets of a single biomolecular complex with atomic force microscopy, JOURNAL OF MOLECULAR RECOGNITION, 2013, 通讯作者
(51) 化学因素对基于DNA折纸界面上的核酸适配体与凝血酶相互作用影响的研究, Chemical factors on the binding reaction of thrombin and aptamer based on DNA origami interface, 电子显微学报, 2013, 第 3 作者
(52) HOPG/水界面纳米气泡与纳米气层的原子力显微技术研究, Investigation on nanobubbles and micropancakes at the HOPG/water interface by atomic force microscopy, 电子显微学报, 2013, 第 4 作者
(53) Facilitating the pickup of individual DNA molecules by AFM nanomanipulation with tips mechanically worn on bare mica, MICROSCOPY RESEARCH AND TECHNIQUE, 2012, 第 4 作者
(54) The opposite effects of Cu(II) and Fe(III) on the assembly of glucagon amyloid fibrils, RSC ADVANCES, 2012, 第 5 作者
(55) Ultrasound Effects on Assembly of Glucagon Fibrils, INTEGRATED FERROELECTRICS, 2012, 通讯作者
(56) Biotemplated fabrication of size controlled palladium nanoparticle chains, JOURNAL OF MATERIALS CHEMISTRY, 2012, 第 4 作者
(57) Confined Water Nanofilm Promoting Nonenzymatic Degradation of DNA Molecules, JOURNAL OF PHYSICAL CHEMISTRY B, 2011, 第 2 作者
(58) In situ monitoring of single molecule binding reactions with time-lapse atomic force microscopy on functionalized DNA origami, NANOSCALE, 2011, 通讯作者
(59) 高湿度环境下衬底表面对牛胰岛素聚集的影响, The effects of substrates on the assembly of bovine insulin under high humidity, 科学通报, 2011, 第 6 作者
(60) Fabrication and application of high quality poly(dimethylsiloxane) stamps by gamma ray irradiation, JOURNAL OF MATERIALS CHEMISTRY, 2011, 第 5 作者
(61) Assembly of glucagon (proto)fibrils by longitudinal addition of oligomers, NANOSCALE, 2011, 第 3 作者
(62) 基于纳米操纵和单分子成像及分析技术的DNA与DNase I相互作用的表面机械生化过程和动力学研究, Mechanochemical activation and kinetics in DNase I digestion revealed by nanomanipulation and single-molecule imaging & analysis, 电子显微学报, 2009, 第 6 作者
(63) Electrochemical fabrication of nanoporous polypyrrole film on HOPG using nanobubbles as templates, ELECTROCHEMISTRY COMMUNICATIONS, 2009, 第 2 作者
(64) Electrochemically Controlled Formation and Growth of Oxygen Nanobubbles and Their Effect on Morphology of Polypyrrole, ACTA CHIMICA SINICA, 2009, 第 2 作者
(65) 电化学控制产生纳米氧气气泡及其对电化学聚合吡咯形貌的影响, Electrochemically Controlled Formation and Growth of Oxygen Nanobubbles and Their Effect on Morphology of Polypyrrole, 化学学报, 2009, 第 2 作者
(66) Enzymatic Digestion of Single DNA Molecules Anchored on Nanogold-Modified Surfaces, NANOSCALE RESEARCH LETTERS, 2009, 通讯作者
(67) Single DNA Molecule Reaction Based On Dip-pen Nanolithography, BIOPHYSICAL JOURNAL, 2009, 第 1 作者
(68) Modification of AFM tips for facilitating picking-up of nanoparticles, CHINESE PHYSICS LETTERS, 2008, 第 8 作者
(69) 戊二醛交联固定病毒颗粒及其在衬底表面上分散的研究, Glutaraldehyde fixing and facilitating dispersion of virus particles on mica and HOPG, 核技术, 2008, 第 7 作者
(70) Modification of AFM Tips for Facilitating Picking-up of Nanoparticles, Modification of AFM Tips for Facilitating Picking-up of Nanoparticles, 中国物理快报:英文版, 2008, 第 8 作者
(71) ORGANIC SOLVENT-ASSISTED TRANSFER PRINTING ON HYDROPHOBIC POLYMER SUBSTRATE WITH HIGH EFFICIENCY, SURFACE REVIEW AND LETTERS, 2008, 第 6 作者
(72) EDTA应用于微接触印刷法制备高密度蛋白微阵列的研究, Fabrication of high-density protein microarray on an EDTA-PDMS substrate by microcontact printing, 核技术, 2008, 第 4 作者
(73) 一种实现可控纳米定位沉积的探针修饰新方法, A new method of coating AFM tip for positioning ink deposition, 核技术, 2008, 第 2 作者
(74) 基于“纳米蘸笔技术”的单个纳米颗粒在不同基底表面的转移, Transfer of single nanoparticle between different surfaces based on single-particle dip-pen nanolithography, 电子显微学报, 2007, 第 3 作者
(75) Single crystal β-Ga2O3: Cr grown by floating zone technique and its optical properties, Science in China. Series E: Technological Sciences, 2007, 第 2 作者
(76) Positioning scission of single DNA molecules with nonspecific endonuclease based on nanomanipulation, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 第 1 作者
(77) 纳米粒子PCR产物的纯化及AFM观察, Purification of nanoparticle PCR products and their topography observed with AFM, 核技术, 2007, 第 2 作者
(78) 硅烷化和多聚赖氨酸化衬底结合容量的比较, Comparison of Binding Capability between Substrates Modified by Silanized Reagent and Polylysine, 分析测试学报, 2006, 第 4 作者
(79) Nano-manipulation of single DNA molecules based on atomic force microscopy, 2005 27TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-7, 2005, 第 8 作者
(80) 单分子研究和定位单分子反应, 2005, 第 1 作者
(81) 免疫微阵列同步多元分析系统的建立及其初步应用, 核技术, 2004, 第 2 作者
(82) 动态组合模式“蘸笔”纳米刻蚀与单个DNA分子上的物理纳米图形制造, 科学通报, 2004, 第 1 作者
(83) 单个DNA分子的拉直操纵和成像, 科学通报, 2000, 第 8 作者
(84) Modified DMC technique for stretching DNA molecules, Modified "DMC" technique for stretching DNA molecules, 核技术:英文版, 1999, 第 4 作者

科研活动

   
科研项目
( 1 ) 纳米生物机器的可控组装与多功能集成, 参与, 国家任务, 2013-05--2018-05
( 2 ) 基于DNA折纸的生物分子相互作用研究, 负责人, 国家任务, 2014-01--2017-12
( 3 ) 基于原子力显微术的生物分子结构和功能研究, 负责人, 国家任务, 2017-01--2020-12
( 4 ) “纳米气泡”微观物化性质研究和应用探索, 参与, 中国科学院计划, 2016-08--2021-12
( 5 ) 功能性纳米材料在代谢性疾病相关解剖结构成像研究的应用, 负责人, 其他任务, 2021-06--2023-06
( 6 ) 纳米材料跨越生物屏障机制与效应调控方法, 负责人, 国家任务, 2021-12--2026-11
( 7 ) IgG-C1q单分子反应的原子力显微术的实时原位成像研究, 负责人, 国家任务, 2022-01--2026-12