基本信息
王雪松  男  博导  中国科学院理化技术研究所
电子邮件: xswang@mail.ipc.ac.cn
通信地址: 中科院理化技术研究所
邮政编码: 100190

招生信息

   
招生专业
070303-有机化学
招生方向
有机光化学

教育背景

1991-09--1996-07   中科院感光化学研究所   理学博士学位
1986-09--1991-07   中国科技大学   理学学士学位

工作经历

   
工作简历
2000-07~现在, 中科院理化技术研究所, 研究员
1998-07~2000-07,美国夏威夷大学化学系, 博士后
1996-07~1998-06,中科院感光化学研究所, 副研
1991-09~1996-07,中科院感光化学研究所, 理学博士学位
1986-09~1991-07,中国科技大学, 理学学士学位

教授课程

光谱及显微成像基础与前沿

专利与奖励

   
奖励信息
(1) 亚洲和泛太平洋光化学学会年轻科学家奖(APA-Prize for young scientist), 其他, 2008
(2) 维生素D3生产新工艺, 二等奖, 国家级, 2007
专利成果
( 1 ) 光化学合成一氯代碳酸乙烯酯的方法及光化学反应器, 2015, 第 2 作者, 专利号: ZL201210397734.9

( 2 ) 利用双波长微流技术制备9β,10-α-去氢黄体酮缩酮的方法及双波长微流光化学反应器, 2015, 第 2 作者, 专利号: ZL201410085871.8

( 3 ) 利用微流光反应技术合成树脂状维生素D3的方法及微流光化学反应器, 2015, 第 2 作者, 专利号: ZL201310560401.8

( 4 ) 光化学异构化反应合成9-β,10-α-去氢黄体酮缩酮的方法, 2014, 第 5 作者, 专利号: ZL 2010 1 0621400.6

( 5 ) 光化学异构化反应从全反式番茄红素合成顺式番茄红素异构体的方法, 2011, 第 1 作者, 专利号: ZL 2007 1 0099721.2

( 6 ) 红光发射荧光染料及其合成方法与用途, 2010, 第 1 作者, 专利号: ZL 2005 1 0011716.2

( 7 ) 合成16-脱氢孕甾双烯醇酮醋酸酯及其同类物的新方法, 2009, 第 4 作者, 专利号: Z L2005 1 0011966.6

( 8 ) 红色荧光染料及其合成方法与用途, 2008, 第 4 作者, 专利号: ZL 01145135.1

( 9 ) 光化学合成维生素D2的方法, 2007, 第 4 作者, 专利号: ZL 2004 1 0058042.7

出版信息

   
发表论文
(1) Photo-induced mitochondrial DNA damage and NADH depletion by -NO2 modified Ru(II) complexes, Chem. Commun., 2021, 通讯作者
(2) Selective and efficient photoinactivation of intracellular Staphylococcus aureus and MRSA with little accumulation of drug resistance: application of a Ru(II) complex with photolabile ligands, J. Med. Chem., 2021, 通讯作者
(3) Pyrene modification enables enhanced two-photon excited ligand dissociation of a Ru(II) complex containing monodentate ligands, Inorg. Chim. Acta, 2021, 通讯作者
(4) UCNP@BSA@Ru nanoparticles with tumor-specific and NIR-triggered efficient PACT activity in vivo, Dalton Trans., 2021, 通讯作者
(5) Electronic effects on polypyridyl Co complexbased water reduction catalysts, RSC Adv., 2021, 通讯作者
(6) A Ru-anthraquinone dyad with triple functions of PACT, photoredox catalysis and PDT upon red light irradiation, Dalton Trans., 2021, 通讯作者
(7) Polypyridyl Co complex-based water reduction catalysts: why replace a pyridine group with isoquinoline rather than quinoline?, Dalton Trans., 2021, 通讯作者
(8) The modification of a pyrene group makes a Ru(II) complex versatile, Chem. Commun., 2021, 通讯作者
(9) Smart use of “ping-pong” energy transfer to improve the two-photon photodynamic activity of an Ir(III) complex, Chem. Commun., 2020, 通讯作者
(10) A Ru(II)-based nanoassembly exhibiting theranostic PACT activity in NIR region, Part. Part. Syst. Charact., 2020, 通讯作者
(11) Incorporation of 7-dehydrocholesterol into liposomes as a simple, universal and efficient way to enhance anticancer activity by combining PDT and photoactivated chemotherapy, Chem. Commun., 2019, 通讯作者
(12) Chloromethyl-modified Ru(II) complexes enabling large pH jumps at low concentrations through photoinduced hydrolysis, Chem. Sci., 2019, 通讯作者
(13) Selective photoinactivation of methicillin-resistant staphylococcus aureus by highly positively charged Ru(II) complexes, Chem. Eur. J., 2019, 通讯作者
(14) Fluorination on non-photolabile dppz ligands for improving Ru(II) complex-based photoactivated chemotherapy, Dalton Trans., 2019, 通讯作者
(15) A nuclear permeable Ru(II)-based photoactivated chemotherapeutic agent towards a series of cancer cells: in vitro and in vivo studies, Dalton Trans., 2019, 通讯作者
(16) Mitochondria targeted and NADH triggered photodynamic activity of chloromethyl modified Ru(II) complexes under hypoxic conditions, Chem. Commun., 2019, 通讯作者
(17) Photoactivatable Ru complexes containing a RuO bond:Photoinduced ligand dissociation and DNA damage, Journal of Photochemistry and Photobiology A: Chemistry, 2018, 通讯作者
(18) Photocleavable antimicrobial peptide mimics for precluding antibiotic resistance, New J. Chem, 2018, 通讯作者
(19) A Ru(II) complex-based DNA photocleaver having intense absorption in the phototherapeutic window, Inorg. Chem., 2017, 通讯作者
(20) Photoactivatable Ru complexes containing a Ru-O bond: Photoinduced ligand dissociation and DNA damage, J. Photochem. Photobiol. A: Chem., 2017, 通讯作者
(21) Syntheses of 7-dehydrocholesterol peroxides and their improved anticancer activity and selectivity over ergosterol peroxide, New J. Chem, 2017, 通讯作者
(22) An upconversion nanoparticle/Ru(II) polypyridyl complex assembly for NIR-activated release of a DNA covalent-binding agent, RSC Adv., 2016, 通讯作者
(23) A ferrocenyl pyridine-based Ru(II) arene complex capable of generating ·OH and 1O2 along with photoinduced ligand dissociation, RSC Adv., 2016, 通讯作者
(24) A ferrocenyl pyridine-based Ru(II) arene complex capable of generating ·OH and 1O2 along with photoinduced ligand dissociation, RSC Adv., 2016, 通讯作者
(25) DNA photocleavage by non-innocent ligand-based Ru(II) complexes, Inorg. Chem, 2016, 通讯作者
(26) Photocatalytic hydrogen evolution by Cu(II) complexes, Dalton Trans., 2016, 通讯作者
(27) Substituent effect and wavelength dependence of the photoinduced Ru-O homolysis in the [Ru(bpy)2(py-SO3)]+-type complexes, Dalton Trans, 2016, 通讯作者
(28) DNA photocleavage in anaerobic conditions by a Ru(II) complex: a new mechanism, Chem. Commun., 2015, 通讯作者
(29) A bivalent cationic dye enabling selective photoinactivation against Gram-negative bacteria, Chem. Commun, 2015, 通讯作者
(30) A novel azopyridine-based Ru(II) complex with GSH-responsive DNA photobinding ability, Chem. Commun, 2015, 通讯作者
(31) Fine control on the photochemical and photobiological properties of Ru(II) arene complexes, Dalton Trans, 2015, 通讯作者
(32) Two novel BODIPY-Ru(II) arene dyads enabling effective photo-inactivation against cancer cells, Dalton Trans., 2015, 通讯作者
(33) Enhanced photocatalytic hydrogen production by introducing the carboxylic acid group into cobaloxime catalysts, Dalton Trans., 2015, 通讯作者
(34) An unexpected role of the monodentate ligand in photocatalytic hydrogen production of the pentadentate ligand-based cobalt complexes, Chem. Commun., 2014, 通讯作者
(35) Fusion of photodynamic therapy and photoactivated chemotherapy: a novel Ru(II) arene complex with dual activities of photobinding and photocleavage toward DNA, Dalton Trans., 2014, 通讯作者
(36) Selective photodynamic inactivation of bacterial cells over mammalian cells by new triarylmethanes, Langmuir, 2014, 通讯作者
(37) BODIPY-Modified Ru(II) arene Complex----a New Ligand Dissociation Mechanism and a Novel Strategy to Red Shift the Photoactivation Wavelength of Anticancer Metallodrugs, Dalton Trans., 2013, 通讯作者
(38) Self-Assembly of Anionic Porphyrins and Alkaline or Alkaline Earth Metal Ions Mediated by Cucurbit[7,8]uril, ChemPhysChem, 2013, 通讯作者
(39) A Ruthenium(II) arene complex showing emission enhancement and photocleavage activity towards DNA from singlet and triplet excited states respectively, Dalton Trans., 2013, 通讯作者
(40) Ruthenium(II)-Arene Complexes with Strong Fluorescence: Insight into the Underlying Mechanism, Chem. Eur. J., 2012, 通讯作者
(41) Large Improvement in the Catalytic Activity Due to Small Changes in the Diimine Ligands: New Mechanistic Insight into the Dirhodium(II,II) Complex-Based Photocatalytic H2 Production, Inorg. Chem., 2012, 通讯作者
(42) Oxovanadium(IV) based Hypocrellin B Complexes with Enhanced Photodynamic Activity, Dalton Trans., 2012, 通讯作者
(43) DNA photocleavage by a cationic BODIPY dye via both singlet oxygen and hydroxyl radical: New insight into the photodynamic mechanism of BODIPYs, ChemPhysChem, 2012, 通讯作者
(44) Small change in structure leads to large difference in protein photocleavage: Two porphyrins bearing rhodanine-based pendants, Photochem. Photobiol. Sci., 2012, 通讯作者
(45) Ratiometric fluorescent sensing of bacterial lipopolysaccharide by a simple combination of a cationic dye and an anionic dye, Sensors & Actuators: B. Chem., 2012, 通讯作者
(46) Photodynamic inactivation of Escherichia coli by porphyrin cytochrome c, New J. Chem., 2012, 通讯作者
(47) A new Co(III)–hypocrellin B complex with enhanced photonuclease activity, J. Inorg. Biochem., 2011, 通讯作者
(48) A new squaraine and Hg2+-based chemosensor with tunable measuring range for thiol-containing amino acids, New J. Chem., 2011, 通讯作者
(49) The effects of micellar media on the photocatalytic H2 production from water, International Journal of Hydrogen Energy, 2011, 通讯作者
(50) Selectivity Tune of Fluoride Ion Sensing for Phenolic OH-Containing BODIPY Dyes, Sensors & Actuators: B. Chem., 2011, 通讯作者
(51) pH-responsive silica nanoparticles for controllable 1O2 generation, Nanotech, 2010, 通讯作者
(52) Greatly enhanced binding of a cationic porphyrin towards bovine serum albumin by cucurbit[8]uril, Phys. Chem. Chem. Phys., 2010, 通讯作者
(53) A new phenol red-modified porphyrin as efficient protein photocleaving agent, Phys. Chem. Chem. Phys., 2010, 通讯作者
(54) A new heteroleptic Ru(II) polypyridyl complex with long wavelength absorption and high singlet oxygen quantum yield, Chem. Eur. J., 2010, 通讯作者
(55) “[Ru(bpy)3-n(dpb)n]2+: Unusual photophysical property and efficient DNA photocleavage activity”, Inorg. Chem., 2010, 通讯作者

科研活动

   
科研项目
( 1 ) 钌(II)多吡啶配合物—电子受体超分子光敏体系缺氧环境下的光动力活性研究, 负责人, 国家任务, 2008-01--2010-12
( 2 ) pH响应有机/无机纳米复合单重态氧光敏体系的制备及其光动力活性研究, 负责人, 国家任务, 2009-01--2011-12
( 3 ) 16-DPA的光敏氧化合成法, 负责人, 中国科学院计划, 2009-01--2011-12
( 4 ) 化学生物学的几个重要问题研究, 参与, 中国科学院计划, 2006-11--2010-12
( 5 ) C-H键活化和高效转化的基本科学问题----可见光敏化活化C-H键和惰性杂原子键的反应机制, 参与, 国家任务, 2014-01--2018-12
( 6 ) BODIPY敏化Ru(II) arene光活化抗癌药物的研究, 负责人, 国家任务, 2013-01--2016-12
( 7 ) 三芳基甲烷染料-葫芦[n]脲超分子体系光动力灭菌活性研究, 负责人, 国家任务, 2012-01--2015-12
( 8 ) 精细化工氰化物原料替代技术及污染减排技术与示范, 负责人, 国家任务, 2012-01--2014-12
( 9 ) 高效太阳能光化学转化, 参与, 中国科学院计划, 2016-07--2021-07
( 10 ) 重大疾病相关的若干重要难检活性小分子细胞内纳米传感研究, 参与, 国家任务, 2013-01--2018-12