基本信息
高云华 女 博导 中国科学院理化技术研究所
电子邮件: yhgao@mail.ipc.ac.cn
通信地址: 北京市海淀区中关村东路29号
邮政编码:
电子邮件: yhgao@mail.ipc.ac.cn
通信地址: 北京市海淀区中关村东路29号
邮政编码:
招生信息
招生专业
070303-有机化学070303-有机化学
招生方向
生物传感器和微针药物释放系统研究生物传感器和微针药物释放系统研究
教育背景
1991-04--1996-03 OKAYAMA 大学(日本) 博士1990-05--1991-03 OKAYAMA 大学(日本) 研究生预科1983-09--1987-06 北京师范大学 学士
工作经历
工作简历
2000-12~2016-08,中国科学院理化技术研究所, 研究员1998-08~2000-12,OKAYAMA 大学(日本), 讲师1991-04~1996-03,OKAYAMA 大学(日本), 博士1990-05~1991-03,OKAYAMA 大学(日本), 研究生预科1989-08~1990-04,ASAHI 大学(日本), 客座研究员1987-07~1989-07,大连大学, 助教1983-09~1987-06,北京师范大学, 学士
社会兼职
2019-08-18-2024-08-18,世界中医药学会联合会, 副会长
2010-11-01-2016-08-24,化学物质环境管理专家评审委员会, 委员
2010-10-01-2016-08-24,全国微机电技术标准化技术委员会, 委员
-今,
2010-11-01-2016-08-24,化学物质环境管理专家评审委员会, 委员
2010-10-01-2016-08-24,全国微机电技术标准化技术委员会, 委员
-今,
教授课程
光生物学
专利与奖励
专利成果
( 1 ) 具有多层结构的涂层微针、其制备方法及包含该涂层微针的微针贴片, 2022, 第 1 作者, 专利号: CN114146046A( 2 ) 一种耐热型可植入式聚合物微针及其制备方法和应用, 2021, 第 1 作者, 专利号: CN113827544A( 3 ) 一种不可溶的透皮微针贴片及其制备方法和应用, 2021, 第 1 作者, 专利号: CN113797155A( 4 ) 一种GMR芯片及包括其的磁敏免疫检测卡, 2019, 第 1 作者, 专利号: CN109917139A( 5 ) 一种具有精准放血功能的梅花针拔罐器, 2019, 第 3 作者, 专利号: CN106377421B( 6 ) 一种丙烯酰氨基苯硼酸聚合物及其制备与应用, 2017, 第 1 作者, 专利号: CN107082840A( 7 ) 一种用于液体注模成型加工过程中除气固定的真空抽板, 2017, 第 1 作者, 专利号: CN106915023A( 8 ) 一种聚丙烯酸酯柔曲性溶胀微针, 2017, 第 1 作者, 专利号: CN106806354A( 9 ) 一种用于制作聚合物微针的设备, 2017, 第 1 作者, 专利号: CN106426687A( 10 ) 一种柔曲性缓释微针贴片及其制备方法, 2017, 第 1 作者, 专利号: CN106422045A( 11 ) 一种具有精准放血功能的梅花针拔罐器, 2017, 第 3 作者, 专利号: CN106377421A( 12 ) 一种可扩宽免疫检测范围的生物芯片, 2016, 第 1 作者, 专利号: CN106198955A( 13 ) 一种基于纳米材料的生物检材中海洛因的检验方法, 2016, 第 2 作者, 专利号: CN105929181A( 14 ) 一种利用钩状效应拓展检测范围的生物芯片及其检测方法, 2016, 第 1 作者, 专利号: CN105823880A( 15 ) 一种检测多靶标的自驱动微流体检测卡, 2016, 第 1 作者, 专利号: CN105572337A( 16 ) 一种含有格拉司琼的长效透皮贴剂, 2016, 第 1 作者, 专利号: CN105520921A( 17 ) 自溶性微针透皮贴片及其制备方法, 2016, 第 1 作者, 专利号: CN105311000A( 18 ) 一种微针贴片及包装盒, 2016, 第 1 作者, 专利号: CN205007427U( 19 ) 一种可扩展检测范围的捕获抗体竞争夹心免疫检测方法及生物传感器, 2015, 第 1 作者, 专利号: CN104597232A( 20 ) 一种青蒿素衍生物的皮内给药微针制剂的制备方法, 2015, 第 1 作者, 专利号: CN104382884A( 21 ) 一种可溶性微针疫苗贴片及其制备方法, 2014, 第 1 作者, 专利号: CN104027324A( 22 ) 一种聚合物材料微针阵列贴片的制作方法, 2014, 第 1 作者, 专利号: CN103568160A( 23 ) 一种血液纯化的方法, 2013, 第 1 作者, 专利号: CN103389241A( 24 ) 实心微针阵列器件载药的方法及装置, 2013, 第 1 作者, 专利号: CN103386164A( 25 ) 脂质体和包含脂质体的个人护理组合物, 2013, 第 5 作者, 专利号: CN103327965A( 26 ) 甘草次酸水凝胶制剂及其制备方法和应用, 2012, 第 1 作者, 专利号: CN102784095A( 27 ) 多样品磁敏传感器阵列生物芯片测试仪, 2011, 第 1 作者, 专利号: CN101206217B( 28 ) 一种透皮给药试剂盒, 2011, 第 1 作者, 专利号: CN102039000A( 29 ) 一种透皮给药组合制剂, 2011, 第 1 作者, 专利号: CN102018655A( 30 ) 透皮药物组合制剂和透皮药物试剂盒, 2011, 第 1 作者, 专利号: CN102008730A( 31 ) 一种数字化控制光反应系统, 2011, 第 1 作者, 专利号: CN101226279B( 32 ) 抑制固体材料表面非特异性吸附的方法, 2010, 第 1 作者, 专利号: CN101745495A( 33 ) 一种具有溶液储室兼泵体结构的微流体样品舟, 2009, 第 1 作者, 专利号: CN101458249A( 34 ) 用于生物芯片修饰蛋白的修饰剂与其组合物、及其修饰蛋白的方法, 2009, 第 1 作者, 专利号: CN101441214A( 35 ) 一种对磁敏传感生物芯片进行自动测量的仪器, 2008, 第 1 作者, 专利号: CN101281191A( 36 ) 识别稀土金属离子镝或铒的化合物及其合成方法和用途, 2008, 第 1 作者, 专利号: CN101209982A( 37 ) 含有紫杉醇或多烯紫杉醇的弹性纳米囊泡制剂及其制备方法, 2008, 第 1 作者, 专利号: CN101209251A( 38 ) 弹性纳米囊泡载体及其制备方法和用途, 2008, 第 1 作者, 专利号: CN101209348A( 39 ) 可同时测试多种样品的磁传感器生物芯片样品舟, 2008, 第 1 作者, 专利号: CN101158697A( 40 ) 微流体样品舟, 2008, 第 1 作者, 专利号: CN101126765A( 41 ) 酯水解催化剂及其合成方法, 2007, 第 1 作者, 专利号: CN101032696A( 42 ) 一种磁控芯片微混合器, 2007, 第 2 作者, 专利号: CN2874467Y( 43 ) 微型实心硅针阵列芯片及其制备方法和用途, 2005, 第 2 作者, 专利号: CN1569271A( 44 ) 金属微针阵列芯片及其制备方法和用途, 2005, 第 2 作者, 专利号: CN1562402A( 45 ) 高聚物微流控芯片的制备方法, 2003, 第 1 作者, 专利号: CN1464303A( 46 ) 利用黑曲霉纤维素酶制备低分子量壳聚糖的方法, 2003, 第 1 作者, 专利号: CN1463989A
出版信息
发表论文
(1) Aspirin microcrystals deposited on high-density microneedle tips for the preparation of soluble polymer microneedles, DRUG DELIVERY AND TRANSLATIONAL RESEARCH, 2023, 第 11 作者(2) Dissolvable polymeric microneedles loaded with aspirin for antiplatelet aggregation, ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023, 第 11 作者(3) Soluble Polymer Microneedles Loaded with Interferon Alpha 1b for Treatment of Hyperplastic Scar, POLYMERS, 2023, 第 11 作者(4) Design and Evaluation of Complex Polypeptide-Loaded Dissolving Microneedles for Improving Facial Wrinkles in Different Areas, Polymers, 2022, 第 11 作者(5) One-Shot Full-Range Quantification of Multi-Biomarkers With Different Abundance by a Tandem Giant Magnetoresistance Assay, FRONTIERS IN CHEMISTRY, 2022, 第 11 作者(6) Two-Layer Sustained-Release Microneedles Encapsulating Exenatide for Type 2 Diabetes Treatment, PHARMACEUTICS, 2022, 第 11 作者(7) The hygroscopicity of polymer microneedles on the performance of dissolving behavior for transdermal delivery, INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, 2022, 第 5 作者(8) 基于UPLC-MS/MS技术测定大鼠血浆中的氨甲环酸, Determination of tranexamic acid in rat plasma by UPLC-MS/MS, 化学研究, 2022, 第 7 作者(9) 增强经皮通透性的Ca2+交联海藻酸盐基可溶胀微针的工艺优化: 更适用于酸性药物, International Journal of Pharmaceutics, 2022, 第 11 作者(10) Transcutaneous immunization via dissolving microneedles protects mice from lethal influenza H7N9 virus challenge, Vaccine, 2022, 第 11 作者(11) Preparation and evaluation of dissolving microneedle loaded with azelaic acid for acne vulgaris therapy, JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2022, 第 11 作者(12) 以干扰素为模型的基于络合包衣微针的增强药物释放与缓释研究, Asian Journal of Pharmaceutical Sciences, 2021, 第 11 作者(13) A tandem giant magnetoresistance assay for one-shot quantification of clinically relevant concentrations of N-terminal pro-B-type natriuretic peptide in human blood, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2021, 第 11 作者(14) 新型溶解性微针制剂协同治疗黄褐斑:氨甲环酸和甘草提取物的联合作用, International Journal of Pharmaceutics, 2021, 第 11 作者(15) 基于酸碱组合原理制作含有壬二酸和苦参碱的可溶性微针, European Journal of Pharmaceutical Sciences, 2021, 第 11 作者(16) Dynamic Range Expansion of the C-Reactive Protein Quantification with a Tandem Giant Magnetoresistance Biosensor, ACS OMEGA, 2021, 第 11 作者(17) Novel dissolving microneedles preparation for synergistic melasma therapy: Combined effects of tranexamic acid and licorice extract, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021, 第 11 作者(18) Acid-base combination principles for preparation of anti-acne dissolving microneedles loaded with azelaic acid and matrine, EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021, 第 11 作者(19) 海藻糖对植入式PLGA微针中左炔诺孕酮释放的影响, Polymers, 2020, 第 11 作者(20) 改性壳聚糖滴眼液对兔白念珠菌性角膜炎的治疗作用及安全性评价, Efficacy and safety of modified chitosan eye drops in the treatment of Candida albicanskeratitis in rabbits, 中华实验眼科杂志, 2020, 第 8 作者(21) Intradermal Implantable PLGA Microneedles for Etonogestrel Sustained Release, JOURNAL OF PHARMACEUTICAL SCIENCES, 2020, 第 11 作者(22) Enhanced transdermal delivery of polydatin via a combination of inclusion complexes and dissolving microneedles for treatment of acute gout arthritis, JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2020, 第 6 作者(23) 聚合物微针的吸湿性对透皮给药微针溶解性能的影响, INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, 2020, 第 11 作者(24) Exploring Trehalose on the Release of Levonorgestrel from Implantable PLGA Microneedles, POLYMERS, 2020, 第 11 作者(25) HPLC-DAD法同时测定凝胶膜剂中氨甲环酸和维生素C乙基醚的含量, Simultaneous determination of tranexamic acid and 3-O-ethyl ascorbyl ether in compound gel by HPLC-DAD, 药物分析杂志, 2020, 第 5 作者(26) 氨甲环酸在治疗黄褐斑领域中的应用进展, Research progress of tranexamic acid in treatment of melasma, 药学研究, 2020, 第 5 作者(27) 基于微机电系统技术的新型微针耳穴贴压治疗失眠疗效观察, Comparative Study on Therapeutic Effect of New Microneedle Auricular Acupuncture on Insomnia Based on MEMS Technology, 辽宁中医杂志, 2020, 第 9 作者(28) Multiplex measurement of twelve tumor markers using a GMR multi-biomarker immunoassay biosensor, BIOSENSORS & BIOELECTRONICS, 2019, 第 9 作者(29) 使用GMR多靶标免疫生物传感器对12项肿瘤标志物的同时检测, Biosensors and Bioelectronics, 2019, 第 11 作者(30) Multiplex measurement of twelve tumor markers using a GMR multi-biomarker immunoassay biosensor, BIOSENSORS AND BIOELECTRONICS, 2019, 第 11 作者(31) Fabrication of bi-layer photocrosslinked GelMA/PEGDA fibrous membrane for guided bone regeneration materials, MATERIALS LETTERS, 2019, 第 4 作者(32) Development of a Photo-Crosslinking, Biodegradable GelMA/PEGDA Hydrogel for Guided Bone Regeneration Materials, MATERIALS, 2018, 第 6 作者(33) Swept Source Optical Coherence Tomography System for Transdermal Drug Delivery Imaging by Microneedles, CHINESE JOURNAL OF LASERS-ZHONGGUO JIGUANG, 2018, 第 3 作者(34) An acryl resin-based swellable microneedles for controlled release intradermal delivery of granisetron, DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2018, 第 11 作者(35) 用于微针经皮给药成像的扫频OCT系统, Swept Source Optical Coherence Tomography System for Transdermal Drug Delivery Imaging by Microneedles, 中国激光, 2018, 第 3 作者(36) 孕二烯酮缓释避孕微针含量及其有关物质的测定方法研究, Determination of related substances and the content of gestodene sustained release contraception microneedles, 中国计划生育学杂志, 2018, 第 4 作者(37) 重组金黄色葡萄球菌肠毒素B蛋白可溶性微针制备及免疫效果研究, Fabrication and efficacy of dissolving microneedles for recombinant Staphylococcus aureus enterotoxin B protein, 免疫学杂志, 2018, 第 8 作者(38) Dissolving Microneedles Loaded With Etonogestrel Microcrystal Particles for Intradermal Sustained Delivery, JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 第 11 作者(39) Influences of several factors on the photolysis of glabridin under UV irradiation, JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 2017, 第 5 作者(40) 流感病毒灭活疫苗可溶性微针制备及评价, 免疫学杂志, 2017, 第 11 作者(41) On-Chip determination of glycated hemoglobin with a novel boronic acid copolymer, SENSORS AND ACTUATORS B-CHEMICAL, 2017, 第 11 作者(42) Influences of several factors on the photolysis of glabridin under UV irradiation, JOURNAL OF PHOTOCHEMISTRY & PHOTOBIOLOGY, A: CHEMISTRY, 2017, 第 5 作者(43) On-Chip determination of glycated hemoglobin with a novel boronic acid copolymer, SENSORS & ACTUATORS: B. CHEMICAL, 2017, 第 6 作者(44) Strategies for meloxicam delivery to and across the skin: a review, DRUG DELIVERY, 2016, 第 11 作者(45) DNA-based vaccination against hepatitis B virus using dissolving microneedle arrays adjuvanted by cationic liposomes and CpG ODN, DRUG DELIVERY, 2016, 第 11 作者(46) 快速检测心型脂肪酸结合蛋白的荧光免疫微流体测试卡, A Microfluidic Fluorescence Immunoassay Test Card for Rapid Detection of Heart-type Fatty Acid Binding Protein, 分析化学, 2016, 第 7 作者(47) 中国微针技术相关专利综述与分析, Review and analysis of patents on microneedle technology in China, 今日药学, 2016, 第 3 作者(48) Dissolving microneedle-based intradermal delivery of interferon-alpha-2b, DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2016, 第 11 作者(49) Controlled synthesis of porous Co3O4 nanofibers by spiral electrospinning and their application for formaldehyde oxidation, RSC ADVANCES, 2016, 第 4 作者(50) Systemic delivery of artemether by dissolving microneedles. International Journal of Pharmaceutics, International Journal of Pharmaceutics, 2016, 第 11 作者(51) 蒿甲醚可溶解微针透皮贴片的制备和评价, Preparation and Evaluation of Artemether-Loaded Dissolving Microneedles, 今日药学, 2016, 第 6 作者(52) A Microfluidic Fluorescence Immunoassay Test Card for Rapid Detection of Heart-type Fatty Acid Binding Protein, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2016, 第 11 作者(53) Systemic delivery of artemether by dissolving microneedles, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2016, 第 11 作者(54) Synthesis and magnetic properties of BaFe11.92La(0.08���x)NdxO19 (x=0, 0.02, 0.04, 0.06, 0.08) via gel-precursor self-propagating combustion process, JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2015, 第 6 作者(55) An Integrated Giant Magnetoresistance Microfluidic Immuno-sensor for Rapid Detection and Quantification of D-dimer, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2015, 第 11 作者(56) 心衰标志物可视化联合检测方法研究, Rapid Visual Immunoassay of Multi-biomarker for Heart Failure Based on Magnetic Particles Images, 影像科学与光化学, 2015, 第 5 作者(57) Determination of Affinity and Kinetic Constants of the Biotin-Streptavidin Complex Using Microfluidic GMR Biosensors, IEEE TRANSACTIONS ON MAGNETICS, 2015, 第 11 作者(58) An Integrated Giant Magnetoresistance Microfluidic Immuno-sensor for Rapid Detection and Quantification of D-dimer, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2015, 第 11 作者(59) Dissolving Microneedle-based Intradermal Delivery of Interferon-��-2b, Drug Dev Ind Pharm, 2015, 第 11 作者(60) Preparation and properties of La-doped barium ferrite/poly (3-methylthiophene) composites, ADVANCED COMPOSITE MATERIALS, 2015, 第 10 作者(61) A Novel High-sensitivity Cardiac Multi-biomarker Detection System Based on Microfluidic Chip and GMR Sensor, IEEE TRANSACTIONS ON MAGNETICS, 2015, 第 11 作者(62) 壳寡糖的生物活性研究进展, Research Progress on Production of ChitooUgosaccharides, 明胶科学与技术, 2015, 第 3 作者(63) Dissolving Microneedle Arrays for Intradermal Immunization of Hepatitis B Virus DNA Vaccine, PROCEDIA IN VACCINOLOGY, 2015, 第 4 作者(64) A Novel High-Sensitivity Cardiac Multibiomarker Detection System Based on Microfluidic Chip and GMR Sensors, IEEE TRANSACTIONS ON MAGNETICS, 2015, 第 11 作者(65) Controllable coating of microneedles for transdermal drug delivery, DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2015, 第 11 作者(66) 降解制备壳寡糖研究进展, Research Progresson in Production of Chitooligosaccharides, 明胶科学与技术, 2014, 第 4 作者(67) 明胶作为左旋肉碱贴膏剂载体的体外经皮渗透性评价, Hydrogel Patch Prepared from Gelatin Combined with Functional Microneedle Arrays for L-carnitine Transdermai Delivery, 明胶科学与技术, 2014, 第 4 作者(68) A GMR Biosensing System with Sub-50ppm Sensitivity, 2014 IEEE INTERNATIONAL CONFERENCE ON ELECTRON DEVICES AND SOLID-STATE CIRCUITS (EDSSC), 2014, 第 4 作者(69) Enhanced transcutaneous immunization via dissolving microneedle array loaded with liposome encapsulated antigen and adjuvant, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2013, 第 11 作者(70) Immunological effects of microneedle-mediated insulin delivery: Preliminary rat studies, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2013, 第 11 作者(71) 多靶标生物标志物检测的微流体磁敏生物传感器研制, Development of Integrated Microfluidic Magnetic Biosensor for Multi-biomarker Detection, 分析化学, 2013, 第 4 作者(72) 可生物降解高分子微针的制作及透皮应用, Fabrication of Biodegradable Polymer Microneedles for Transdermal Drug Delivery Applications, NANOTECHNOLOGY AND PRECISION ENGINEERING, 2013, 第 5 作者(73) 微针辅助左旋肉碱水凝胶制剂体内外经皮渗透性评价, In vitro and in vivo transdermal evaluation of L-carnitine gel assisted by functional microneedle arrays, 中国新药杂志, 2013, 第 3 作者(74) Effective transcutaneous immunization against hepatitis B virus by a combined approach of hydrogel patch formulation and microneedle arrays, BIOMEDICAL MICRODEVICES, 2013, 第 6 作者(75) Development of Integrated Microfluidic Magnetic Bioprocessor for Multi-biomarker Detection, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2013, 第 11 作者(76) A fully automated IVD system based on MTJ arrays and superparamagnetic particles, Journal of Applied Physics, 2012, 第 11 作者(77) A Novel Transdermal Fomulation of 18 beta-Glycyrrhetic Acid with Lysine for Improving Bioavailability and Efficacy, SKIN PHARMACOLOGY AND PHYSIOLOGY, 2012, (78) 磁敏传感器竞争免疫法检测牛奶中的氯霉素残留量, Magnetoresistive Biosensor for Detection of Chloramphenicol Residue in Milk, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2012, 第 11 作者(79) A fully automated in vitro diagnostic system based on magnetic tunnel junction arrays and superparamagnetic particles, JOURNAL OF APPLIED PHYSICS, 2012, 第 11 作者(80) Enhanced transdermal delivery of 18 beta-glycyrrhetic acid via elastic vesicles: in vitro and in vivo evaluation, DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2012, 第 11 作者(81) Novel lyophilized hydrogel patches for convenient and effective administration of microneedle-mediated insulin delivery, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2012, 第 11 作者(82) Simultaneous basal-bolus delivery of fast-acting insulin and its significance in diabetes management, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2012, 第 2 作者(83) 赖氨酸在甘草次酸弹性囊泡形成过程中的作用机制, Mechanism of Lysine on the Formation of Glycyrrhetic Acid Elastic Vesicles, 物理化学学报, 2011, 第 4 作者(84) 应用FRAP技术评价蛋白在聚丙烯酰胺-丙烯酸凝胶中的扩散行为, Study on the Protein Diffusion Behavior in the Poly (Acrylamide-co-Acrylic Acid) Copolymer by FRAP Technique, 影像科学与光化学, 2011, 第 4 作者(85) 表面活性剂-醇质体增强多烯紫杉醇经皮给药的渗透性研究, Enhancement of transdermal delivery of docetaxel by surfactant-ethanolic liposomes, 中国药学:英文版, 2011, 第 5 作者(86) 柠檬酸盐络合-共沸蒸馏-低温燃烧法制备纳米铁酸镍粉及其表征, Preparation of Nanosize Nickel Ferrite Powders by Citrin Coordination-Azeotropic Distillation Process-Low Temperature Combustion Method and Its Charaterization, 机械工程材料, 2011, 第 7 作者(87) Enhanced Bioavailability of L-Carnitine After Painless Intradermal Delivery vs. Oral Administration in Rats, PHARMACEUTICAL RESEARCH, 2011, 第 11 作者(88) Mechanism of Lysine on the Formation of Glycyrrhetic Acid Elastic Vesicles, ACTA PHYSICO-CHIMICA SINICA, 2011, 第 11 作者(89) Effect of Surface Chemical Properties of a Silicon Chip on Antibody Immobilization, ACTA PHYSICO-CHIMICA SINICA, 2010, 第 11 作者(90) Surface Functionalization of Zinc Oxide by Carboxyalkylphosphonic Acid Self-Assembled Monolayers, LANGMUIR, 2010, 第 11 作者(91) Construction and evaluation of a novel end-column amperometric detection system for electrophoresis microchips, SCIENCE CHINA-CHEMISTRY, 2010, 第 2 作者(92) Sustained release of insulin through skin by intradermal microdelivery system, BIOMEDICAL MICRODEVICES, 2010, 第 11 作者(93) 镝(III)离子比色/荧光传感器: 杯芳席夫碱的设计与合成, A Colorimetric/Fluorescent Chemosensor for Dysprosium(III) Ion: Design and Synthesis of a Calix4arene-Schiff Base, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2010, 第 5 作者(94) Microneedle pretreatment improves efficacy of cutaneous topical anesthesia, AMERICAN JOURNAL OF EMERGENCY MEDICINE, 2010, 第 7 作者(95) 硅基芯片表面化学性质对蛋白质固定化的影响, Effect of Surface Chemical Properties of a Silicon Chip on Antibody Immobilization, 物理化学学报, 2010, 第 4 作者(96) 同步荧光法测定大鼠血浆中牛血清白蛋白的研究, Study on the Determination of Bovine Serum Albumin in Rat Plasma by Synchronous Fluorescence Spectrometry, 影像科学与光化学, 2010, 第 2 作者(97) 镝(Ⅲ)离子比色/荧光传感器:杯芳席夫碱的设计与合成, A Colorimetric/Fluorescent Chemosensor for Dysprosium(���) Ion:Design and Synthesis of a Calix4arene-Schiff Base, 有机化学, 2010, 第 5 作者(98) 镝(III)离子比色/荧光传感器: 杯芳席夫碱的设计与合成, A Colorimetric/Fluorescent Chemosensor for Dysprosium(III) Ion: Design and Synthesis of a Calix4arene-Schiff Base, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2010, 第 5 作者(99) 新型芯片电泳柱端安培检测系统的构建与评价, Construction and evaluation of a novel end-column amperometric detection system for electrophoresis microchip, 中国科学:B辑, 2009, 第 2 作者(100) Fluorinated silicon surfaces under mixed surfactants: resistance to nonspecific protein adsorption for biosensing, LANGMUIR, 2009, 第 11 作者(101) Synthesis and Photochromic Property of Three Novel Calix4arene-Schiff Bases, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2009, 第 5 作者(102) 新型杯4席夫碱的合成及光致变色性质研究, Synthesis and Photochromic Property of Three Novel Calix4arene-Schiff Bases, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2009, 第 5 作者(103) 新型芯片电泳柱端安培检测系统的构建与评价, Construction and evaluation of a novel end-column amperometric detection system for electrophoresis microchip, 中国科学:B辑, 2009, 第 2 作者(104) Colorimetric Test Kit for Cu2+ Detection, ORGANIC LETTERS, 2008, 第 3 作者(105) Enhancement of skin permeation of docetaxel: A novel approach combining microneedle and elastic liposomes, JOURNAL OF CONTROLLED RELEASE, 2008, 第 11 作者(106) 无痛微针透皮贴片对局部应用利多卡因的促渗作用, Painless microneedle transdermal patch enhances permeability of topically applied lidocaine, 中国新药杂志, 2008, 第 4 作者(107) Microneedle-based drug delivery: studies on delivery parameters and biocompatibility, BIOMEDICAL MICRODEVICES, 2008, 第 11 作者(108) A selective colorimetric chemosensor based on calixarene framework for lanthanide ions-Dy 3+ and Er 3+, TETRAHEDRON LETTERS, 2007, 第 11 作者(109) Sequential-injection on-line preconcentration using chitosan resin functionalized with 2-amino-5-hydroxy benzoic acid for the determination of trace elements in environmental water samples by inductively coupled plasma-atomic emission spectrometry, TALANTA, 2007, 第 6 作者(110) Synthesis, characterization and photochromic studies of three novel calix4arene���Schiff bases, SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2007, 第 11 作者(111) Functionalization of chitosan with 3,4-dihydroxybenzoic acid for the adsorption/collection of uranium in water samples and its determination by inductively coupled plasma-mass spectrometry, ANALYTICA CHIMICA ACTA, 2007, 第 6 作者(112) Synthesis of a novel host-calix4arene derivative and its application to recognition analysis of lanthanide ions, CHEMICALJOURNALOFCHINESEUNIVERSITIESCHINESE, 2006, 第 11 作者(113) 新型杯4芳烃衍生物的合成及其对镧系金属离子的识别研究, Synthesis of a Novel Host-calix 4 arene Derivative and Its Application to r Recognition Analysis of Lanthanide Ions, 高等学校化学学报, 2006, 第 4 作者(114) 微针透皮给药系统研究进展, 中医外治杂志, 2005, 第 1 作者(115) Controlled transdermal delivery of model drug compounds by MEMS microneedle array, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2005, 第 11 作者(116) 微粒子化学发光免疫测定促甲状腺素敏感性方法的建立与应用, A novel microbeads-based chemiluminescence immunoassay for detecting human thyrotropin, 细胞与分子免疫学杂志, 2004, 第 5 作者(117) 毛细管电泳芯片简化安培检测系统的研制, Development of Simplified Amperometric Detector and Its Application in Integrated ITO Electrode Microfluidic Chip, 高等学校化学学报, 2004, 第 2 作者(118) 微流通道中的磁力搅拌混合及其应用研究, Development of Magnetic Micromixing Method for Microfluidic Chip, 高等学校化学学报, 2004, 第 4 作者(119) 塑料芯片毛细管电泳电化学检测系统及其性能评价, Configuration and Property Evaluation of a Novel Plastic Capillary Electrophoresis Microchip with Electrochemical Detection System, 高等学校化学学报, 2004, 第 2 作者(120) 一种新型电泳芯片柱端安培检测池结构, A Novel End-column Amperometric Detection System for Microchip Capillary Electrophoresis, 高等学校化学学报, 2004, 第 2 作者(121) 一种新型电泳芯片柱端安培检测池结构, 第二届全国微全分析系统学术会议论文摘要集, 2004, 第 1 作者(122) 一种玻璃微流控芯片的制作方法研究, A Novel Microfabrication Technique for Glass Microfluidic Chips, 高等学校化学学报, 2004, 第 3 作者(123) 金属离子Cu^2+,Co^2+,Ni^2+的微芯片电泳分离及化学发光检测, 化学学报, 2003, 第 4 作者
科研活动
科研项目
( 1 ) 聚合物微针给药技术生产工艺研发及应用, 负责人, 中国科学院计划, 2020-01--2021-12( 2 ) 可生物降解长效缓控释新剂型的避孕及兼治疗作用的新药具研发, 参与, 国家任务, 2016-06--2020-12( 3 ) 流感疫苗溶解微针实验室中试工艺研究, 负责人, 研究所自主部署, 2016-05--2018-04( 4 ) 癌症分子早期超敏检测及疗效跟踪系统, 负责人, 地方任务, 2014-06--2017-06( 5 ) 现场快速生化参数检测技术及新产品开发, 负责人, 国家任务, 2013-01--2015-12( 6 ) 微纳技术药物释放系统, 负责人, 国家任务, 2013-01--2013-12( 7 ) 生物医学传感器研制, 负责人, 国家任务, 2013-01--2013-12( 8 ) 胰岛素微针透皮给药免疫原性研究, 负责人, 研究所自主部署, 2010-07--2012-12( 9 ) 基于新型磁性隧道结器件的生物传感芯片基础研究, 负责人, 国家任务, 2010-01--2012-12( 10 ) 新型临床即时检验分析(POCT)仪器试剂一体化检测系统的研制, 负责人, 地方任务, 2010-01--2011-12( 11 ) 基于免疫识别作用的磁敏感生物检测系统, 参与, 国家任务, 2009-07--2012-12( 12 ) 功能性成份透皮输送系统, 负责人, 境内委托项目, 2008-09--2012-12( 13 ) 微针透皮制剂研究, 负责人, 境内委托项目, 2008-01--2009-12( 14 ) 建立功能性成分透皮输送系统, 负责人, 其他国际合作项目, 2007-03--2011-10( 15 ) 生物传感器技术初步之研究与探讨, 负责人, 境内委托项目, 2007-01--2008-12( 16 ) 胰岛素微针体内透皮动力学评价, 负责人, 境内委托项目, 2007-01--2008-12
参与会议
(1)载药微针制剂的设计与研究 世界中医药学会联合会经皮给药专业委员会第四届学术年会 2018-08-13