基本信息
齐建勋  男  博导  中国科学院微生物研究所
电子邮件: jxqi@im.ac.cn
通信地址: 北京市朝阳区北辰西路1号院3号
邮政编码:

研究领域

采用结构生物学方法解析病原微生物侵入宿主的分子机制。基于病原与宿主的互作机制,进一步开展病原微生物防控研究,具体包括如下三个个方面:

1.基于病原优势表位设计纳米颗粒亚单位疫苗(nano-paiticle vaccine),来预防病原微生物的侵入;

2.基于已有抗原优势表位信息设计特异性抗体,来阻断病原微生物的侵入;

3.基于病原生命周期中关键酶设计小分子抑制剂,来阻断病原的生命周期,进而开发成高效阻断病原的抑制剂。

招生信息

每年招收一名硕士研究生和一名博士研究生。

招生专业
100103-病原生物学
071011-生物物理学
招生方向
病原微生物侵入宿主细胞的分子机制研究
基于优势表位的疫苗设计
抑制剂设计

教育背景

2004-09--2008-07   中国科学院物理研究所   研究生学历博士学位

工作经历

   
工作简历
2016-08~现在, 中国科学院微生物研究所, 研究员
2011-08~2016-06,中国科学院微生物研究所, 副研究员
2008-07~2011-08,中国科学院微生物研究所, 助理研究员
社会兼职
2022-07-01-今,中国生物化学与分子生物学学会蛋白质分会, 委员
2020-10-24-今,中国性病艾滋病防治协会, 委员

教授课程

结构生物学与医学研究
结构生物学在医学中的应用

专利与奖励

   
奖励信息
(1) Clarivate Highly Cited Researcher 2023, , 其他, 2023
(2) 全球前2%顶尖科学家榜单(World's Top 2% Scientists), , 其他, 2023
(3) Clarivate Highly Cited Researcher 2022, 其他, 2022
(4) Clarivate Highly Cited Researcher 2021, 其他, 2021
(5) 中华预防医学会科学技术奖, 一等奖, 部委级, 2017
(6) 北京市科学技术奖, 一等奖, 省级, 2011
专利成果
[1] 一种呼吸道合胞病毒抗原制备方法和应用. 2023-05-12.

[2] 一种呼吸道合胞病毒二价抗原制备方法和应用. 2023-10-12.

[3] 苏宝玲, 施一, 高福, 齐建勋, 赵学金, 王寒. 3-AP在制备抑制应病毒的药物中的应用. 202211439204.6, 2023-11-17.

[4] 高福, 王奇慧, 戴连攀, 杜沛, 齐建勋, 徐坤, 马雪慧. 新冠病毒三聚体嵌合疫苗及其用途. CN: CN115947872A, 2023-04-11.

[5] 高福, 王奇慧, 戴连攀, 杜沛, 齐建勋, 徐坤, 马雪慧. 新冠病毒三聚体嵌合疫苗及其用途. CN: CN115197331A, 2022-10-18.

[6] 高福, 仝舟, 赵欣, 仝剑宇, 齐建勋, 刘科芳, 马素芳, 谢谊. 一种高效中和新型冠状病毒的人源抗体及其应用. CN: CN114395034A, 2022-04-26.

[7] 高福, 仝舟, 赵欣, 仝剑宇, 齐建勋, 刘科芳, 马素芳, 谢谊. 一种新型冠状病毒稀有广谱表位的人源抗体及其应用. CN: CN114456264A, 2022-05-10.

[8] 高福, 仝舟, 赵欣, 仝剑宇, 齐建勋, 刘科芳, 马素芳, 谢谊. 一种新型冠状病毒稀有广谱表位的人源抗体及其应用. CN: CN114456264A, 2022-05-10.

[9] 高福, 齐建勋, 傅立峰. 一种氮杂双环[3.1.0]己烷衍生物及其制备方法和用途. CN: CN115433256A, 2022-12-06.

[10] 高福, 齐建勋, 谭文杰, 傅立峰, 叶飞, 李学兵, 冯永. 博赛泼维在治疗或改善新型冠状病毒肺炎中的应用. CN: CN113143918A, 2021-07-23.

[11] 高福, 谭文杰, 齐建勋, 傅立峰, 叶飞, 李学兵, 冯永. GC376化合物的新用途. CN: CN113143917A, 2021-07-23.

[12] 严景华, 史瑞, 王奇慧, 齐建勋, 高福. 与新型冠状病毒的抗体有效结合的表位. CN: CN113527444A, 2021-10-22.

[13] 高福, 严景华, 李燕, 逯光文, 齐建勋. 一种中东呼吸综合征冠状病毒抗体及其制备方法. CN: CN103864924A, 2014-06-18.

出版信息

   
发表论文
(1) A Wider and Deeper Peptide-Binding Groove for the Class I Molecules from B15 Compared with B19 Chickens Correlates with Relative Resistance to Marek's Disease, JOURNAL OF IMMUNOLOGY, 2023, 第 18 作者
(2) Cryo-EM structure of severe fever with thrombocytopenia syndrome virus, NATURE COMMUNICATIONS, 2023, 通讯作者
(3) Near-atomic architecture of Singapore grouper iridovirus and implications for giant virus assembly, NATURE COMMUNICATIONS, 2023, 通讯作者
(4) In Silico Discovery of Small Molecule Modulators Targeting the Achilles' Heel of SARS-CoV-2 Spike Protein, ACS CENTRAL SCIENCE, 2023, 第 8 作者
(5) Mechanistic insights into DNA binding and cleavage by a compact type I-F CRISPR-Cas system in bacteriophage, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 通讯作者
(6) Structure of monkeypox virus DNA polymerase holoenzyme, SCIENCE, 2023, 第 5 作者
(7) The mechanism of STING autoinhibition and activation, MOLECULAR CELL, 2023, 第 17 作者
(8) Characterization of the high-affinity anti-CTLA-4 monoclonal antibody JS007 for immune checkpoint therapy of cancer, MABS, 2023, 其他(合作组作者)
(9) An updated atlas of antibody evasion by SARS-CoV-2 Omicron sub-variants including BQ.1.1 and XBB, CELL REPORTS MEDICINE, 2023, 通讯作者
(10) Host range and structural analysis of bat-origin RshSTT182/200 coronavirus binding to human ACE2 and its animal orthologs, EMBO JOURNAL, 2023, 通讯作者
(11) Molecular mechanism of de novo replication by the Ebola virus polymerase, Nature, 2023, 通讯作者
(12) Protective prototype-Beta and Delta-Omicron chimeric RBD-dimer vaccines against SARS-CoV-2, CELL, 2022, 第 30 作者
(13) VarEPS: an evaluation and prewarning system of known and virtual variations of SARS-CoV-2 genomes, NUCLEIC ACIDS RESEARCH, 2022, 第 9 作者
(14) Structural and inhibitor sensitivity analysis of influenza B-like viral neuraminidases derived from Asiatic toad and spiny eel, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 第 7 作者
(15) Molecular basis of differential receptor usage for naturally occurring CD55-binding and -nonbinding coxsackievirus B3 strains, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 第 14 作者
(16) Structural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS-CoV-2 sub-variants BA.2 and BA.1.1, CELL, 2022, 第 17 作者
(17) Molecular Basis of Mink ACE2 Binding to SARS-CoV-2 and Its Mink-Derived Variants, JOURNAL OF VIROLOGY, 2022, 第 15 作者
(18) Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2, CELL, 2022, 通讯作者
(19) Atlas of currently available human neutralizing antibodies against SARS-CoV-2 and escape by Omicron sub-variants BA.1/BA.1.1/BA.2/BA.3, IMMUNITY, 2022, 通讯作者
(20) Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals, Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals, NATIONAL SCIENCE REVIEW, 2022, 第 18 作者
(21) Binding and structural basis of equine ACE2 to RBDs from SARS-CoV, SARS-CoV-2 and related coronaviruses, NATURE COMMUNICATIONS, 2022, 第 8 作者
(22) Structure of the Ebola virus polymerase complex, NATURE, 2022, 第 6 作者
(23) Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape, NATURE COMMUNICATIONS, 2022, 通讯作者
(24) Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes, Nature Communications, 2022, 通讯作者
(25) 平急一体化传染病防控平台在新冠肺炎疫情中的应用, Application of an Integrated Platform for Basic and Applied Research in the Prevention and Control of the COVID-19 Pandemic, 中国科学基金, 2022, 第 2 作者
(26) Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous beta 2-Microglobulin, JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2021, 通讯作者
(27) Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir, Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir, 创新(英文), 2021, 第 7 作者
(28) Molecular basis of cross-species ACE2 interactions with SARS-CoV-2-like viruses of pangolin origin, EMBO JOURNAL, 2021, 其他(合作组作者)
(29) The molecular basis for SARS-CoV-2 binding to dog ACE2, NATURE COMMUNICATIONS, 2021, 通讯作者
(30) Structural basis of malarial parasite RIFIN-mediated immune escape against LAIR1, CELL REPORTS, 2021, 通讯作者
(31) Structure-based design of 5 '-substituted 1,2,3-triazolylated oseltamivir derivatives as potent influenza neuraminidase inhibitors, RSC ADVANCES, 2021, 第 6 作者
(32) Atypical TNF-TNFR superfamily binding interface in the GITR-GITRL complex for T cell activation, CELL REPORTS, 2021, 第 7 作者
(33) 新型冠状病毒结合穿山甲ACE2受体的分子机制, 科学通报, 2021, 第 8 作者
(34) Cross-species recognition of SARS-CoV-2 to bat ACE2, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 通讯作者
(35) Human group A rotavirus P25 VP8* specifically binds to A-type histo-blood group antigen, VIROLOGY, 2021, 第 3 作者
(36) Cell entry by SARS-CoV-2, TRENDS IN BIOCHEMICAL SCIENCES, 2021, 通讯作者
(37) Protective Zika vaccines engineered to eliminate enhancement of dengue infection via immunodominance switch, NATURE IMMUNOLOGY, 2021, 第 15 作者
(38) Molecular insights into receptor binding of recent emerging SARS-CoV-2 variants, NATURE COMMUNICATIONS, 2021, 通讯作者
(39) Structural insights into the cis and trans assembly of human trophoblast cell surface antigen 2, ISCIENCE, 2021, 第 5 作者
(40) Crystal structure of the African swine fever virus core shell protein p15, Crystal structure of the African swine fever virus core shell protein p15, 生物安全与健康(英文), 2021, 第 8 作者
(41) Binding and molecular basis of the bat coronavirus RaTG13 virus to ACE2 in humans and other species, CELL, 2021, 通讯作者
(42) A broadly protective antibody that targets the flavivirus NS1 protein, SCIENCE, 2021, 第 8 作者
(43) Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals, NATURE MICROBIOLOGY, 2021, 第 13 作者
(44) Crystal structure of the African swine fever virus core shell protein p15, BIOSAFETY AND HEALTH, 2021, 第 8 作者
(45) Structural basis for the inhibition of the SARS-CoV-2 main protease by the anti-HCV drug narlaprevir, Structural basis for the inhibition of the SARS-CoV-2 main protease by the anti-HCV drug narlaprevir, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 第 6 作者
(46) Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease, NATURE COMMUNICATIONS, 2020, 通讯作者
(47) Structural insight into arenavirus replication machinery, NATURE, 2020, 第 10 作者
(48) Analysis of ACE2 Gene-Encoded Proteins Across Mammalian Species, FRONTIERS IN VETERINARY SCIENCE, 2020, 第 6 作者
(49) Structures of the four Ig-like domain LILRB2 and the four-domain LILRB1 and HLA-G1 complex, CELLULAR & MOLECULAR IMMUNOLOGY, 2020, 第 4 作者
(50) Structural basis of HCoV-19 fusion core and an effective inhibiton peptide against virus entry, Emerging Microbes & infections, 2020, 通讯作者
(51) The structural basis of African swine fever virus pA104R binding to DNA and its inhibition by stilbene derivatives, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 通讯作者
(52) Identification of a hotspot on PD-L1 for pH-dependent binding by monoclonal antibodies for tumor therapy, Identification of a hotspot on PD-L1 for pH-dependent binding by monoclonal antibodies for tumor therapy, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2020, 第 6 作者
(53) A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS, CELL, 2020, 第 18 作者
(54) Cryo-EM structure of the varicella-zoster virus A-capsid, NATURE COMMUNICATIONS, 2020, 通讯作者
(55) Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2, CELL REPORTS, 2020, 第 10 作者
(56) The crystal structure of the emerging human-infecting hepatitis E virus E2s protein, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 第 4 作者
(57) Structures of the SARS-CoV-2 nucleocapsid and their perspectives for drug design, EMBO JOURNAL, 2020, 第 5 作者
(58) Structural Basis of Glycan Recognition in Globally Predominant Human P8Rotavirus, Structural Basis of Glycan Recognition in Globally Predominant Human P8 Rotavirus, VIROLOGICA SINICA, 2020, 第 4 作者
(59) N-glycosylation of PD-1 promotes binding of camrelizumab, EMBO REPORTS, 2020, 第 7 作者
(60) Molecular basis of Coxsackievirus A10 entry using the two-in-one attachment and uncoating receptor KRM1, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 通讯作者
(61) Targeting multiple epitopes on the spike protein:a new hope for COVID-19 antibody therapy, Targeting multiple epitopes on the spike protein: a new hope for COVID-19 antibody therapy, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2020, 通讯作者
(62) Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus, MBIO, 2020, 第 3 作者
(63) Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2, CELL DISCOVERY, 2020, 第 15 作者
(64) Structural basis of HCoV-19 fusion core and an effective inhibition peptide against virus entry, EMERGING MICROBES & INFECTIONS, 2020, 通讯作者
(65) Molecular Basis of Binding between Middle East Respiratory Syndrome Coronavirus and CD26 from Seven Bat Species, JOURNAL OF VIROLOGY, 2020, 第 2 作者
(66) Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2, CELL, 2020, 通讯作者
(67) A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2, NATURE, 2020, 第 20 作者
(68) Molecular basis of EphA2 recognition by gHgL from gammaherpesviruses, NATURE COMMUNICATIONS, 2020, 第 4 作者
(69) A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2, SCIENCE, 2020, 第 22 作者
(70) Structural Analysis of Rabies Virus Glycoprotein Reveals pH-Dependent Conformational Changes and Interactions with a Neutralizing Antibody, CELL HOST & MICROBE, 2020, 第 5 作者
(71) Molecular basis for feedback inhibition of tyrosine-regulated 3-deoxy- d - arabino- heptulosonate-7-phosphate synthase from Escherichia coli, JOURNAL OF STRUCTURAL BIOLOGY, 2019, 通讯作者
(72) Structural and functional insights of the capsid protein from Zika virus, JOURNAL OF IMMUNOLOGY, 2019, 第 3 作者
(73) Crystal Structure of African Swine Fever Virus dUTPase Reveals a Potential Drug Target, MBIO, 2019, 第 5 作者
(74) Structural insight into RNA synthesis by influenza D polymerase, NATURE MICROBIOLOGY, 2019, 第 14 作者
(75) Cryo-EM Structure of the African Swine Fever Virus, CELL HOST & MICROBE, 2019, 第 16 作者
(76) Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein, CELL, 2019, 第 17 作者
(77) Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats, PLOS BIOLOGY, 2019, 第 9 作者
(78) Neutralization mechanism of human monoclonal antibodies against rift valley fever virus, NATURE MICROBIOLOGY, 2019, 第 8 作者
(79) Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 第 2 作者
(80) Crystal structure and function of Rbj: A constitutively GTP-bound small G protein with an extra DnaJ domain, Crystal structure and function of Rbj: A constitutively GTP-bound small G protein with an extra DnaJ domain, PROTEIN & CELL, 2019, 第 4 作者
(81) Molecular Basis of a Protective/Neutralizing Monoclonal Antibody Targeting Envelope Proteins of both Tick-Borne Encephalitis Virus and Louping Ill Virus, JOURNAL OF VIROLOGY, 2019, 第 2 作者
(82) Light chain modulates heavy chain conformation to change protection profile of monoclonal antibodies against influenza A viruses, CELL DISCOVERY, 2019, 第 4 作者
(83) Glycosylation-independent binding of monoclonal antibody toripalimab to FG loop of PD-1 for tumor immune checkpoint therapy, MABS, 2019, 第11作者
(84) Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin, CELL REPORTS, 2019, 第 4 作者
(85) Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B, CELL, 2019, 第 17 作者
(86) Postfusion structure of human-infecting Bourbon virus envelope glycoprotein, JOURNAL OF STRUCTURAL BIOLOGY, 2019, 第 2 作者
(87) Structure-function analysis of neutralizing antibodies to H7N9 influenza from naturally infected humans, NATURE MICROBIOLOGY, 2019, 第 15 作者
(88) The FG Loop of PD-1 Serves as a "Hotspot" for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy, ISCIENCE, 2019, 其他(合作组作者)
(89) Structural insight into multistage inhibition of CRISPR-Cas12a by AcrVA4, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 第 8 作者
(90) Double Lock of a Human Neutralizing and Protective Monoclonal Antibody Targeting the Yellow Fever Virus Envelope, CELL REPORTS, 2019, 第 18 作者
(91) GII.13/21 Noroviruses Recognize Glycans with a Terminal beta-Galactose via an Unconventional Glycan Binding Site, JOURNAL OF VIROLOGY, 2019, 第 3 作者
(92) Distinct PD-L1 binding characteristics of therapeutic monoclonal antibody durvalumab, Distinct PD-L1 binding characteristics of therapeutic monoclonal antibody durvalumab, PROTEIN & CELL, 2018, 通讯作者
(93) Structural features and kinetic characterization of alanine racemase from Bacillus pseudofirmus OF4, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 第 5 作者
(94) An Invariant Arginine in Common with MHC Class II Allows Extension at the C-Terminal End of Peptides Bound to Chicken MHC Class I, JOURNAL OF IMMUNOLOGY, 2018, 第 8 作者
(95) Crystal Structure of the Capsid Protein from Zika Virus, JOURNAL OF MOLECULAR BIOLOGY, 2018, 通讯作者
(96) Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab, CELL REPORTS, 2018, 第 16 作者
(97) Structural and functional insights into MCR-2 mediated colistin resistance, SCIENCE CHINA-LIFE SCIENCES, 2018, 第 3 作者
(98) Discovery and Analysis of Invertebrate IgV(J)-C2 Structure from Amphioxus Provides Insight into the Evolution of the Ig Superfamily, JOURNAL OF IMMUNOLOGY, 2018, 第 3 作者
(99) Genetic Analysis of Reemerging GII.P16-GII.2 Noroviruses in 2016-2017 in China, JOURNAL OF INFECTIOUS DISEASES, 2018, 第11作者
(100) Molecular basis of binding between the global post-transcriptional regulator CsrA and the T3SS chaperone CesT, NATURE COMMUNICATIONS, 2018, 第 5 作者
(101) Glycan Binding Specificity and Mechanism of Human and Porcine P6/P19 Rotavirus VP8*s, JOURNAL OF VIROLOGY, 2018, 第 3 作者
(102) Human Group C Rotavirus VP8*s Recognize Type A Histo-Blood Group Antigens as Ligands, JOURNAL OF VIROLOGY, 2018, 第 3 作者
(103) The Postfusion Structure of the Heartland Virus Gc Glycoprotein Supports Taxonomic Separation of the Bunyaviral Families Phenuiviridae and Hantaviridae, JOURNAL OF VIROLOGY, 2018, 第 4 作者
(104) Heterosubtypic Protections against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses, MBIO, 2018, 第 8 作者
(105) The Structure of the MHC Class I Molecule of Bony Fishes Provides Insights into the Conserved Nature of the Antigen-Presenting System, JOURNAL OF IMMUNOLOGY, 2017, 第 3 作者
(106) Alternate binding modes of anti-CRISPR viral suppressors AcrF1/2 to Csy surveillance complex revealed by cryo-EM structures, CELL RESEARCH, 2017, 第 5 作者
(107) Structure of the S1 subunit C-terminal domain from bat-derived coronavirus HKU5 spike protein, VIROLOGY, 2017, 第 2 作者
(108) Two classes of protective antibodies against Pseudorabies virus variant glycoprotein B: Implications for vaccine design, PLOS PATHOGENS, 2017, 第 5 作者
(109) Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains, NATURE COMMUNICATIONS, 2017, 第 5 作者
(110) Structural basis of nectin-1 recognition by pseudorabies virus glycoprotein D, PLOS PATHOGENS, 2017, 第 3 作者
(111) Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy., CELL RESEARCH, 2017, 通讯作者
(112) Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy, EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2017, 
(113) Structures of human-infecting Thogotovirus fusogens support a common ancestor with insect baculovirus, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 通讯作者
(114) Conserved V delta 1 Binding Geometry in a Setting of Locus-Disparate pHLA Recognition by delta/alpha beta T Cell Receptors (TCRs): Insight into Recognition of HIV Peptides by TCRs, JOURNAL OF VIROLOGY, 2017, 第 4 作者
(115) Remarkably similar CTLA-4 binding properties of therapeutic ipilimumab and tremelimumab antibodies, ONCOTARGET, 2017, 第 3 作者
(116) Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 第 20 作者
(117) Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus-Derived CD8(+) T Cell Epitopes and Host MHC, JOURNAL OF IMMUNOLOGY, 2017, 第 14 作者
(118) An unexpected N-terminal loop in PD-1 dominates binding by nivolumab, NATURE COMMUNICATIONS, 2017, 第 7 作者
(119) The crystal structure of Zika virus NS5 reveals conserved drug targets, EMBO JOURNAL, 2017, 第 6 作者
(120) Crystal Structure of the Marburg Virus Nucleoprotein Core Domain Chaperoned by a VP35 Peptide Reveals a Conserved Drug Target for Filovirus, JOURNAL OF VIROLOGY, 2017, 通讯作者
(121) Distinct PD-L1 binding characteristics of therapeutic monoclonal antibody durvalumab, PROTEIN & CELL, 2017, 第 7 作者
(122) Avian-to-Human Receptor-Binding Adaptation by Influenza A Virus Hemagglutinin H4, CELL REPORTS, 2017, 第 2 作者
(123) Crystal structure of the C-terminal fragment of NS1 protein from yellow fever virus, SCIENCE CHINA-LIFE SCIENCES, 2017, 第 3 作者
(124) Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles, JOURNAL OF IMMUNOLOGY, 2016, 第 3 作者
(125) Putative Receptor Binding Domain of Bat-Derived CoronavirusHKU9 Spike Protein: Evolution of Betacoronavirus Receptor BindingMotifs, BIOCHEMISTRY, 2016, 第 2 作者
(126) Structural basis of collagen recognition by human osteoclast-associated receptor and design of osteoclastogenesis inhibitors, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 第 2 作者
(127) Molecular Basis of Antibody-Mediated Neutralization and Protection Against Flavivirus, IUBMB LIFE, 2016, 第 3 作者
(128) Contribution of intertwined loop to membrane association revealed by zika virus full-length ns1 structure, EMBO JOURNAL, 2016, 第 3 作者
(129) Cross-immunity Against Avian Influenza A(H7N9) Virus in the Healthy Population Is Affected by Antigenicity-Dependent Substitutions, JOURNAL OF INFECTIOUS DISEASES, 2016, 第 10 作者
(130) Diversified Anchoring Features the Peptide Presentation of DLA-88*50801: First Structural Insight into Domestic Dog MHC Class I, JOURNAL OF IMMUNOLOGY, 2016, 第 5 作者
(131) Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1, CELL, 2016, 第 4 作者
(132) Structural and functional analysis of an anchorless fibronectin-binding protein FBPS from Gram-positive bacterium Streptococcus suis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 第 5 作者
(133) Resistance to Mutant Group 2 Influenza Virus Neuraminidases of an Oseltamivir-Zanamivir Hybrid Inhibitor, JOURNAL OF VIROLOGY, 2016, 第 3 作者
(134) The structural basis of chicken, swine and bovine CD8 alpha alpha dimers provides insight into the co-evolution with MHC I in endotherm species, SCIENTIFIC REPORTS, 2016, 第 3 作者
(135) Structure-based tetravalent zanamivir with potent inhibitory activity against drug-resistant influenza viruses, JOURNAL OF MEDICINAL CHEMISTRY, 2016, 第 5 作者
(136) Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies, PROTEIN & CELL, 2016, 第 9 作者
(137) Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody, CELL HOST & MICROBE, 2016, 通讯作者
(138) Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus, SCIENCE TRANSLATIONAL MEDICINE, 2016, 第 6 作者
(139) Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies, Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies, 蛋白质与细胞:英文版, 2016, 第 9 作者
(140) Functional and Structural Characterization of P19 Rotavirus VP8(star) Interaction with Histo-blood Group Antigens, JOURNAL OF VIROLOGY, 2016, 第 10 作者
(141) The NS1 gene from bat-derived influenza-like virus H17N10 can be rescued in influenza A PR8 backbone, JOURNAL OF GENERAL VIROLOGY, 2016, 第 4 作者
(142) Zika virus NS1 structure reveals diversity of electrostatic surfaces among flaviviruses, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2016, 第 2 作者
(143) An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism, PLOS PATHOGENS, 2016, 第 2 作者
(144) A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein, CELL RESEARCH, 2015, 第 6 作者
(145) A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein, CELL RESEARCH, 2015, 第 6 作者
(146) Adaptation of avian influenza A (H6N1) virus from avian to human receptor-binding preference, EMBO JOURNAL, 2015, 第 2 作者
(147) Structural basis for preferential avian receptor binding by the human-infecting H10N8 avian influenza virus, NATURECOMMUNICATIONS, 2015, 第 3 作者
(148) Crystal structures for short-chain pentraxin from zebrafish demonstrate a cyclic trimer with new recognition and effector faces, JOURNAL OF STRUCTURAL BIOLOGY, 2015, 第 2 作者
(149) 埃博拉病毒入侵:人TIM分子的结构与结合PS的分子基础, Crystal structures of human TIM members: Ebolavirus entry-enhancing receptors, 科学通报, 2015, 第 2 作者
(150) Atypical group 1 neuraminidase pH1N1-N1 bound to a group 1 inhibitor, PROTEINCELL, 2015, 通讯作者
(151) Atypical group 1 neuraminidase pH1N1-N1 bound to a group 1 inhibitor, Atypical group 1 neuraminidase pH1N1-N1 bound to a group 1 inhibitor, 蛋白质与细胞:英文版, 2015, 第 9 作者
(152) PILR alpha and PILR beta have a siglec fold and provide the basis of binding to sialic acid, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 第 3 作者
(153) Enabling the 'host jump': structural determinants of receptor-binding specificity in influenza A viruses, NATURE REVIEWS MICROBIOLOGY, 2014, 第 4 作者
(154) Crystal Structure of the Interferon Gamma Receptor Alpha Chain from Chicken Reveals an Undetected Extra Helix Compared with the Human Counterparts, JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2014, 第 2 作者
(155) Structure of Influenza Virus N7: the Last Piece of the Neuraminidase "Jigsaw" Puzzle, JOURNAL OF VIROLOGY, 2014, 通讯作者
(156) The N-Terminal Domain of PA from Bat-Derived Influenza-Like Virus H17N10 Has Endonuclease Activity, JOURNAL OF VIROLOGY, 2014, 第 7 作者
(157) Peptide-dependent Conformational Fluctuation Determines the Stability of the Human Leukocyte Antigen Class I Complex, JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 第 4 作者
(158) Bat Origins of MERS-CoV Supported by Bat Coronavirus HKU4Usage of Human Receptor CD26, CELL HOST & MICROBE, 2014, 第 2 作者
(159) N-alpha-Terminal Acetylation for T Cell Recognition: Molecular Basis of MHC Class I-Restricted N-alpha-Acetylpeptide Presentation, JOURNAL OF IMMUNOLOGY, 2014, 第 3 作者
(160) Crystal Structure of Herpes Simplex Virus 2 gD Bound to Nectin-1 Reveals a Conserved Mode of Receptor Recognition, JOURNAL OF VIROLOGY, 2014, 第 3 作者
(161) Bat-Derived Influenza Hemagglutinin H17 Does Not Bind Canonical Avian or Human Receptors and Most Likely Uses a Unique Entry Mechanism, CELL REPORTS, 2013, 第 7 作者
(162) Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors, NATURE COMMUNICATIONS, 2013, 
(163) Molecular Basis of the Receptor Binding Specificity Switch of the Hemagglutinins from both the 1918 and 2009 Pandemic Influenza A Viruses by a D225G Substitution, JOURNAL OF VIROLOGY, 2013, 第 3 作者
(164) Crystal structures of the two membrane-proximal Ig-like domains(D3D4)of LILRB1/B2:alternative models for their involvement in peptide-HLA binding, Crystal structures of the two membrane-proximal Ig-like domains (D3D4) of LILRB1/B2: alternative models for their involvement in peptide-HLA binding, PROTEIN & CELL, 2013, 第 8 作者
(165) Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26, NATURE, 2013, 
(166) Structure of measles virus hemagglutinin bound to its epithelial receptor nectin-4, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2013, 
(167) Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses, CELL RESEARCH, 2013, 第 13 作者
(168) Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding, SCIENTIFIC REPORTS, 2013, 第 6 作者
(169) Structure and Receptor Binding Specificity of Hemagglutinin H13 from Avian Influenza A Virus H13N6, JOURNAL OF VIROLOGY, 2013, 第 2 作者
(170) Functional and Structural Analysis of Influenza Virus Neuraminidase N3 Offers Further Insight into the Mechanisms of Oseltamivir Resistance, JOURNAL OF VIROLOGY, 2013, 第 2 作者
(171) Structure of the Fusion Core and Inhibition of Fusion by a Heptad Repeat Peptide Derived from the S Protein of Middle East Respiratory Syndrome Coronavirus, JOURNAL OF VIROLOGY, 2013, 第 3 作者
(172) Structural basis for the differential classification of HLA-A*6802 and HLA-A*6801 into the A2 and A3 supertypes, MOLECULAR IMMUNOLOGY, 2013, 第 6 作者
(173) Competition of Cell Adhesion and Immune Recognition: Insights into the Interaction between CRTAM and Nectin-like 2, STRUCTURE, 2013, 第 3 作者
(174) An airborne transmissible avian influenza H5 hemagglutinin seen at the atomic level, SCIENCE, 2013, 
(175) Structures and Receptor Binding of Hemagglutinins from Human-Infecting H7N9 Influenza Viruses, SCIENCE, 2013, 
(176) Structure and receptor-binding properties of an airborne transmissible avian influenza A virus hemagglutinin H5 (VN1203mut), PROTEIN & CELL, 2013, 第 5 作者
(177) T细胞功能学与结构免疫学结合方法鉴定HLA—A2限制性的细胞毒性T淋巴细胞表位富集区, 生理通讯, 2012, 第 2 作者
(178) Structural vaccinology: structure-based design of influenza A virus hemagglutinin subtype-specific subunit vaccines (vol 2, pg 997, 2011), PROTEIN & CELL, 2012, 第 3 作者
(179) Expression, refolding and preliminary X-ray crystallographic analysis of equine MHC class I molecule complexed with an EIAV-Env CTL epitope, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2012, 第 2 作者
(180) Cross-Allele Cytotoxic T Lymphocyte Responses against 2009 Pandemic H1N1 Influenza A Virus among HLA-A24 and HLA-A3 Supertype-Positive Individuals, JOURNAL OF VIROLOGY, 2012, 第 10 作者
(181) Structural and functional characterization of neuraminidase-like molecule N10 derived from bat influenza A virus, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 
(182) Crystal Structure of Cell Adhesion Molecule Nectin-2/CD112 and Its Binding to Immune Receptor DNAM-1/CD226, JOURNALOFIMMUNOLOGY, 2012, 第 8 作者
(183) Insights into Avian Influenza Virus Pathogenicity: the Hemagglutinin Precursor HA0 of Subtype H16 Has an Alpha-Helix Structure in Its Cleavage Site with Inefficient HA1/HA2 Cleavage, JOURNAL OF VIROLOGY, 2012, 第 6 作者
(184) An octamer of enolase from Streptococcus suis, PROTEIN & CELL, 2012, 第 3 作者
(185) Narrow Groove and Restricted Anchors of MHC Class I Molecule BF2*0401 Plus Peptide Transporter Restriction Can Explain Disease Susceptibility of B4 Chickens, JOURNAL OF IMMUNOLOGY, 2012, 第 3 作者
(186) A novel 'open-form' structure of sortaseC from Streptococcus suis, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2011, 第 2 作者
(187) Ⅱ型单纯疱疹病毒糖蛋白D的晶体结构解析, X-ray diffraction analysis of glycoprotein D from Herpes simplex virus type 2, 生物工程学报, 2011, 第 3 作者
(188) Plasticity of human CD8 alpha alpha binding to peptide-HLA-A*2402, MOLECULARIMMUNOLOGY, 2011, 第 2 作者
(189) Expression, crystallization and preliminary crystallographic analysis of C-reactive protein from zebrafish, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2011, 第 2 作者
(190) II型单纯疱疹病毒糖蛋白D的晶体结构解析, X-ray diffraction analysis of glycoprotein D from Herpes simplex virus type 2, CHINESE JOURNAL OF BIOTECHNOLOGY, 2011, 第 3 作者
(191) Structural Analysis of Alkaline beta-Mannanase from Alkaliphilic Bacillus sp N16-5: Implications for Adaptation to Alkaline Conditions, PLOS ONE, 2011, 第 4 作者
(192) Influenza A Virus N5 Neuraminidase Has an Extended 150-Cavity ▿, JOURNAL OF VIROLOGY, 2011, 第 2 作者
(193) Special features of the 2009 pandemic swine-origin influenza A H1N1 hemagglutinin and neuraminidase, Special features of the 2009 pandemic swine-origin influenza A H1N1 hemagglutinin and neuraminidase, 中国科学通报:英文版, 2011, 第 7 作者
(194) The balance of flexibility and rigidity in the active site residues of hen egg white lysozyme, CHINESE PHYSICS B, 2011, 第 1 作者
(195) Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design, JOURNAL OF VIROLOGY, 2011, 第 2 作者
(196) Crystal Structure of Swine Major Histocompatibility Complex Class I SLA-1*0401 and Identification of 2009 Pandemic Swine-Origin Influenza A H1N1 Virus Cytotoxic T Lymphocyte Epitope Peptides, JOURNAL OF VIROLOGY, 2011, 第 2 作者
(197) LILRA3 Binds Both Classical and Non-Classical HLA Class I Molecules but with Reduced Affinities Compared to LILRB1/LILRB2: Structural Evidence, PLOS ONE, 2011, 第 3 作者
(198) Crystallization and preliminary X-ray diffraction analysis of cyclic imide hydrolase (CIH) from Pseudomonas putida YZ-26, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2011, 第 2 作者
(199) T细胞功能学与结构免疫学结合方法鉴定HLA-A2限制性的细胞毒性T淋巴细胞表位富集区, Combined Functional and Structural Methods Verification of an Epitope Clustering Region of HLA-A2-restricted Cytotoxic T Lymphocyte, 科技导报, 2011, 第 2 作者
(200) Two Distinct Conformations of a Rinderpest Virus Epitope Presented by Bovine Major Histocompatibility Complex Class I N*01801: a Host Strategy To Present Featured Peptides, JOURNAL OF VIROLOGY, 2011, 第 3 作者
(201) Special features of the 2009 pandemic swine-origin influenza A H1N1 hemagglutinin and neuraminidase, CHINESE SCIENCE BULLETIN, 2011, 第 7 作者
(202) Insight into the Interaction of Metal Ions with TroA from Streptococcus suis, PLOS ONE, 2011, 第 7 作者
(203) Structural basis of cross-allele presentation by HLA-A*0301 and HLA-A*1101 revealed by two HIV-derived peptide complexes, MOLECULAR IMMUNOLOGY, 2011, 第 5 作者
(204) Complex assembly, crystallization and preliminary X-ray crystallographic studies of the swine major histocompatibility complex molecule SLA-1*1502, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2011, 第 2 作者
(205) Binding of herpes simplex virus glycoprotein d to nectin-1 exploits host cell adhesion, NATURE COMMUNICATIONS, 2011, 
(206) Crystallization and preliminary X-ray studies of native and mutant intimin from enterohaemorrhagic Escherichia coli, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2011, 第 6 作者
(207) Crystallization and preliminary X-ray crystallographic studies of swine CD8 alpha, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2011, 第 2 作者
(208) Structural Basis of Diverse Peptide Accommodation by the Rhesus Macaque MHC Class I Molecule Mamu-B*17: Insights into Immune Protection from Simian Immunodeficiency Virus, JOURNAL OF IMMUNOLOGY, 2011, 第 4 作者
(209) Structural and Functional Analysis of Laninamivir and its Octanoate Prodrug Reveals Group Specific Mechanisms for Influenza NA Inhibition, PLOS PATHOGENS, 2011, 
(210) Structural vaccinology: structure-based design of influenza A virus hemagglutinin subtype-specific subunit vaccines, PROTEIN & CELL, 2011, 第 3 作者
(211) Diverse Peptide Presentation of Rhesus Macaque Major Histocompatibility Complex Class I Mamu-A*02 Revealed by Two Peptide Complex Structures and Insights into Immune Escape of Simian Immunodeficiency Virus ▿, JOURNAL OF VIROLOGY, 2011, 第 3 作者
(212) T细胞功能学与结构免疫学结合方法鉴定HLA-A2限制性的细胞毒性T淋巴细胞表位富集区, Combined Functional and Structural Methods Verification of an Epitope Clustering Region of HLA-A2-restricted Cytotoxic T Lymphocyte, 科技导报, 2011, 第 2 作者
(213) Crystal structure of the swine-origin A (H1N1)- 2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus, Crystal structure of the swine-origin A (H1N1)-2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus, PROTEIN & CELL, 2010, 第 2 作者
(214) Complex assembly, crystallization and preliminary X-ray crystallographic studies of duck MHC class I molecule, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2010, 第 5 作者
(215) Crystallization and preliminary X-ray crystallographic studies of human FAIM protein, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2010, 第 3 作者
(216) A dimeric structure of PD-L1: functional units or evolutionary relics?, A dimeric structure of PD-L1: functional units or evolutionary relics?, PROTEIN & CELL, 2010, 第 5 作者
(217) An improved loopless mounting method for cryocrystallography, An improved loopless mounting method for cryocrystallography, 中国物理:英文版, 2010, 第 1 作者
(218) 灵芝免疫调节蛋白LZ-8的制备和晶体分析, Expression and crystallographic studies of a fungal immunomodulatory protein LZ-8 from a medicinal fungus Ganoderma lucidum, 生物工程学报, 2010, 第 3 作者
(219) Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of SAICAR synthase from Streptococcus suis serotype 2, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2010, 第 3 作者
(220) An improved loopless mounting method for cryocrystallography, CHINESE PHYSICS B, 2010, 第 1 作者
(221) The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2010, 
(222) Novel Immunodominant Peptide Presentation Strategy: a Featured HLA-A*2402-Restricted Cytotoxic T-Lymphocyte Epitope Stabilized by Intrachain Hydrogen Bonds from Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein ▿ †, JOURNAL OF VIROLOGY, 2010, 第 4 作者
(223) The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Acts as a Dominant Immunogen Revealed by a Clustering Region of Novel Functionally and Structurally Defined Cytotoxic T-Lymphocyte Epitopes, JOURNAL OF INFECTIOUS DISEASES, 2010, 第 3 作者
(224) Crystallization and preliminary X-ray study of alkaline alanine racemase from Bacillus pseudofirmus OF4, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2009, 第 2 作者
(225) Crystallization and preliminary X-ray study of alkaline alanine racemase from Bacillus pseudofirmus OF4, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 2009, 第 2 作者
(226) Crystallization and preliminary X-ray analysis of the V domain of human nectin-2, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2009, 第 2 作者
(227) Crystallization and preliminary X-ray analysis of the V domain of human nectin-2, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 2009, 第 2 作者
(228) 恒河猴MHC-I类分子Mamu-A^*02与猴免疫缺陷病毒抗原表位复合物的纯化和晶体学分析, Purification, crystallographic analysis of rhesus MHC-I Mamu-A^*02 complexed with simian immunodeficiency virus nonapeptide, 生物工程学报, 2009, 第 3 作者
(229) Expression, purification, crystallization and preliminary X-ray diffraction analysis of grass carp beta(2)-microglobulin, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 2008, 第 5 作者
(230) Crystallization and preliminary X-ray study of native and selenomethionyl beta-1,4-mannanase AaManA from Alicyclobacillus acidocaldarius Tc-12-31, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 2008, 第 6 作者
(231) Crystallization and crystallographic analysis of human NUDT16, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 2008, 第 5 作者
(232) Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase from Streptococcus suis serotype 2, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2008, 第 3 作者
(233) Crystallization and crystallographic analysis of human NUDT16, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2008, 第 5 作者
(234) Expression, purification, crystallization and preliminary X-ray diffraction analysis of grass carp beta(2)-microglobulin, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2008, 第 5 作者
(235) Crystallization and preliminary X-ray study of native and selenomethionyl beta-1,4-mannanase AaManA from Alicyclobacillus acidocaldarius Tc-12-31, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2008, 第 6 作者
(236) Crystallization and preliminary crystallographic analysis of recombinant immunoglobulin G-binding protein from Streptococcus suis, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2008, 第 5 作者
(237) Structural and biochemical characterization of nsp12-nsp7-nsp8 core polymerase complex from SARS-CoV-2, CELL REPORTS, 第 10 作者
(238) Cell entry of SARS-CoV-2, TRENDS IN BIOCHEMICAL SCIENCES, 通讯作者

科研活动

   
科研项目
( 1 ) H7N9等新型流感病毒跨种传播机制研究, 负责人, 国家任务, 2014-01--2016-12
( 2 ) 寨卡病毒致病机制及其防控策略研究, 负责人, 国家任务, 2016-07--2017-06
( 3 ) 病原与宿主互作的重要蛋白结构解析, 负责人, 国家任务, 2016-07--2020-12
( 4 ) 基于配体-受体互作埃博拉病毒抑制剂的研究, 负责人, 国家任务, 2017-01--2020-12
( 5 ) 非洲猪瘟病毒主要蛋白结构与功能研究, 负责人, 国家任务, 2020-01--2022-12
( 6 ) 新型冠状病毒S蛋白识别受体分子机制研究, 负责人, 地方任务, 2020-02--2020-08
( 7 ) 病毒感染相关大分子信号识别的分子机制及阻断研究, 负责人, 中国科学院计划, 2020-01--2024-12
( 8 ) 肠具核梭杆菌和产毒性脆弱拟杆菌与宿主的关键蛋白 质机器结构、组成和功能及作用机制的解析, 参与, 国家任务, 2020-11--2025-10
( 9 ) 针对重要病原的免疫原设计, 负责人, 国家任务, 2021-11--2024-10
( 10 ) 冠状病毒广谱抑制剂的开发及其对长效免疫记忆的影响, 负责人, 国家任务, 2022-01--2025-12
参与会议
(1)Study on the entry mechanism of SARS-CoV-2 VOCs   第二届冠状病毒国际前沿研究与创新论坛   2023-09-12
(2)冠状病毒入侵机制及抑制剂的阻断研究   冠状病毒国际前沿研究与创新论坛   2021-11-01
(3)新冠病毒入侵分子机制及阻断的结构生物学研究   第八届(重庆)生命前言技术与医药高峰论坛   2020-11-06
(4)SARS-CoV-2:structural insights of virus entry and blocking by MABs and inhibitors   2020-07-16
(5)Structural biology of Zika virus   2018-09-02
(6)Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy   2017-07-16

指导学生

已指导学生

张艳芳  博士研究生  100103-病原生物学  

王晓敏  硕士研究生  077803-病原生物学  

张玉琴  硕士研究生  085238-生物工程  

现指导学生

陈雨露  博士研究生  100103-病原生物学  

丛龙飞  博士研究生  100103-病原生物学  

张曼玲  博士研究生  100103-病原生物学  

贾明珠  博士研究生  100103-病原生物学  

庞尔琪  硕士研究生  077803-病原生物学  

马超  博士研究生  100103-病原生物学  

廖焓伊  硕士研究生  077803-病原生物学  

张缯原  硕士研究生  077803-病原生物学  

孟玉敏  博士研究生  071010-生物化学与分子生物学  

李维维  硕士研究生  077803-病原生物学  

郭文静  硕士研究生  086000-生物与医药  

杨金月  硕士研究生  086000-生物与医药  

袁斌  博士研究生  100103-病原生物学  

燕浩飞  硕士研究生  077803-病原生物学  

郑婷婷  硕士研究生  077803-病原生物学  

张玉琴  博士研究生  100103-病原生物学  

杨金蕾  博士研究生  100103-病原生物学