朱宝利-中国科学院大学-UCAS

基本信息

朱宝利男博导中国科学院微生物研究所
电子邮件： zhubaoli@im.ac.cn
通信地址：北京市朝阳区北辰西路一号院3号
邮政编码： 100101

专利与奖励

专利成果

[1] 朱宝利, 毛梦雨, 律娜, 张瑞芬. 用于检测临床样本中GI.7型诺如病毒的试剂盒及专用引物. CN: CN114317814A, 2022-04-12.

[2] 朱宝利, 毛梦雨, 律娜, 张瑞芬. 用于检测临床样本中GI.5型诺如病毒的试剂盒及专用引物. CN: CN113481328A, 2021-10-08.

[3] 朱宝利, 毛梦雨, 律娜, 张瑞芬. 用于检测临床样本中GI.1型诺如病毒的试剂盒及专用引物. CN: CN113186354A, 2021-07-30.

[4] 朱宝利, 毛梦雨, 律娜, 张瑞芬. 用于检测临床样本中GI.1型诺如病毒的试剂盒及专用引物. CN: CN113186354B, 2023-01-24.

[5] 朱宝利, 律娜, 张瑞芬. 在种水平上鉴定样本中双歧杆菌的方法及其专用引物. CN: CN111363835A, 2020-07-03.

[6] 朱宝利, 律娜, 黄静, 马越, 李晶, 张瑞芬. 在种水平上鉴定环境样本中乳酸菌的引物及方法. CN: CN110804665A, 2020-02-18.

[7] 朱宝利, 封雨晴, 张瑞芬, 律娜, 李晶. 基于惰性真杆菌预测艾滋病人HAART治疗效果的引物. CN: CN108796100A, 2018-11-13.

[8] 朱宝利, 封雨晴, 张瑞芬, 律娜, 李晶. 基于颤杆菌预测艾滋病人HAART治疗效果的引物. CN: CN108754003A, 2018-11-06.

[9] 朱宝利, 律娜, 秦宇轩, 胡永飞, 王黎明, 李晶, 张瑞芬. 用于鉴定哺乳动物肉类的引物及方法. CN: CN105803100A, 2016-07-27.

[10] 朱宝利, 张瑞芬, 律娜, 胡永飞, 王黎明, 李晶. 一株弯曲乳酸杆菌及其微生态制剂. CN: CN105400724A, 2016-03-16.

[11] 朱宝利, 张瑞芬, 律娜, 王黎明, 李晶. 用于防治妇女泌尿生殖道感染的弯曲乳酸杆菌. CN: CN105349474A, 2016-02-24.

[12] 孙照刚, 黄海荣, 苗慧芳, 朱宝利, 陈素婷, 刘飞, 徐玉辉. 一种鉴别结核分枝杆菌复合群菌种的引物及应用. CN: CN104651520A, 2015-05-27.

[13] 朱宝利, 栾春光, 苗慧芳, 杨犀, 张瑞芬. 一种鉴定或辅助鉴定细菌菌门的引物及其应用. CN: CN104372091A, 2015-02-25.

[14] 朱宝利, 张瑞芬, 李晶, 王江. 一株詹氏乳杆菌及其应用. CN: CN104293718A, 2015-01-21.

[15] 朱宝利, 张瑞芬, 李晶, 王江. 一株弯曲乳杆菌及其应用. CN: CN104232537A, 2014-12-24.

[16] 朱宝利, 张卫红, 孙照刚, 苗慧芳, 刘飞, 张瑞芬. 一种检测结核分枝杆菌复合群的引物对及其应用. CN: CN103882130A, 2014-06-25.

[17] 张恒辉, 刘翟, 陈红松, 高福, 陈衍辉, 朱宝利. 用于检测慢性乙型肝炎及肝癌T细胞受体库的引物及试剂盒. CN: CN104212911A, 2014-12-17.

[18] 朱宝利, 张瑞芬, 李晶, 王江. 用于防治细菌性阴道病的詹氏乳杆菌. CN: CN102851248A, 2013-01-02.

[19] 朱宝利, 万康林, 武娜, 张媛媛, 王志云. 一种检测结核分枝杆菌方法及其专用引物. CN: CN102787161A, 2012-11-21.

[20] 朱宝利, 张苑怡, 武娜, 王志云. 可以简便检测NDM-1基因的引物组合物及其应用. CN: CN102154507A, 2011-08-17.

[21] 朱宝利, 武娜, 张苑怡, 王志云. 高特异性检测NDM-1基因的引物组合物及其应用. CN: CN102181558A, 2011-09-14.

[22] 朱宝利, 武娜, 张苑怡, 王志云. 辅助检测NDM-1基因的专用引物及其应用. CN: CN102199669A, 2011-09-28.

[23] 朱宝利, 张苑怡, 武娜, 王志云, 李奉京. 快速检测NDM-1基因的专用引物及其应用. CN: CN102154506A, 2011-08-17.

[24] 朱宝利, 向阳, 杨毅, 张瑞芬, 蔡玉品, 王志云. 用于检测人乳头瘤病毒的试剂. CN: CN101956024A, 2011-01-26.

[25] 朱宝利, 胡永飞, 张立新. 一种酯酶及其编码基因与应用. CN: CN101353649A, 2009-01-28.

[26] 朱宝利, 贾书磊, 律娜, 潘元龙, 张瑞芬. 心血管疾病相关代谢基因和物种数据库的构建方法及应用. CN: CN117894379A, 2024-04-16.

[27] 朱宝利, 贾书磊, 律娜, 潘元龙, 张瑞芬. 一种肺心病相关基因和物种数据库的构建方法及其应用. CN: CN117935939A, 2024-04-26.

[28] 朱宝利, 贾书磊, 律娜, 潘元龙, 张瑞芬. 心血管疾病相关代谢基因和物种数据库的构建方法及应用. CN: CN117894380A, 2024-04-16.

[29] 朱宝利, 毛梦雨, 律娜, 张瑞芬. 用于检测临床样本中GI.7型诺如病毒的试剂盒及专用引物. CN: CN114317814B, 2024-06-14.

[30] 朱宝利, 毛梦雨, 律娜, 张瑞芬. 用于检测临床样本中GI.5型诺如病毒的试剂盒及专用引物. CN: CN113481328B, 2023-10-27.

出版信息

发表论文

[1] Dong, Wanting, Wang, Siyi, Wang, Xi, Xu, Guojin, Liu, Qiuying, Li, Zheng, Lv, Na, Pan, Yuanlong, Xiong, Qian, Liu, Donglai, Zhu, Baoli. Characteristics of Vaginal Microbiota of Women of Reproductive Age with Infections. MICROORGANISMS[J]. 2024, 第 11 作者  通讯作者  12(5): http://dx.doi.org/10.3390/microorganisms12051030.
[2] Guo, Yaqiong, Yuan, Wenjie, Lyu, Na, Pan, Yuanlong, Cao, Xiaoqing, Wang, Yuxuan, Han, Yi, Zhu, Baoli. Association Studies on Gut and Lung Microbiomes in Patients with Lung Adenocarcinoma. MICROORGANISMS[J]. 2023, 第 8 作者  通讯作者  11(3): http://dx.doi.org/10.3390/microorganisms11030546.
[3] Zhang, Weishan, Chen, Keyu, Zhang, Lin, Zhang, Ximeng, Zhu, Baoli, Lv, Na, Mi, Kaixia. The impact of global warming on the signature virulence gene, thermolabile hemolysin, of Vibrio parahaemolyticus. MICROBIOLOGY SPECTRUM[J]. 2023, 第 5 作者http://dx.doi.org/10.1128/spectrum.01502-23.
[4] 任文博, 陈楠, 律娜, 谢建将, 朱宝利, 曾斌. 郫县豆瓣细菌多样性及群落结构动态变化. 微生物学报[J]. 2023, 第 5 作者63(7): 2809-2821, https://actamicro.ijournals.cn/actamicrocn/article/abstract/20230721?st=article_issue.
[5] Wang, Yanan, Xu, Xuebin, Zhu, Baoli, Lyu, Na, Liu, Yue, Ma, Sufang, Jia, Shulei, Wan, Bo, Du, Yongkun, Zhang, Gaiping, Gao, George F. Genomic analysis of almost 8,000 Salmonella genomes reveals drivers and landscape of antimicrobial resistance in China. MICROBIOLOGY SPECTRUM[J]. 2023, 第 3 作者http://dx.doi.org/10.1128/spectrum.02080-23.
[6] 陈楠, 郭亚琼, 律娜, 李凤琴, 陈历俊, 向雪松, 王欣, 刘烈刚, 王红伟, 智发朝, 何方, 陈卫, 杨瑞馥, 朱宝利. 食品用乳酸杆菌和双歧杆菌泛基因组多态性及菌株间功能基因差异分析. 中国科学:生命科学[J]. 2023, 第 14 作者53(5): 711-724, http://lib.cqvip.com/Qikan/Article/Detail?id=7109849995.
[7] 陈楠, 律娜, 朱宝利. 常见益生菌与鉴定方法. 营养学报[J]. 2023, 第 3 作者45(2): 107-111, http://lib.cqvip.com/Qikan/Article/Detail?id=7109935265.
[8] Li Zheng, Wang Qing, Lv Na, Xu Guojin, Yang Xuemei, Zhu Baoli. Genome-wide identification of endogenous retrovirus elements and their active transcription in mink genome. mLife[J]. 2023, 第 6 作者2(2): 201-208, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7524694&detailType=1.
[9] 朱宝利, 杨瑞馥. 益生菌与健康专题序言. 微生物学报[J]. 2022, 第 1 作者62(3): 771-773, https://actamicro.ijournals.cn/actamicrocn/article/abstract/20220301?st=article_issue.
[10] Liu, Dongxin, Huang, Fei, Zhang, Guoliang, He, Wencong, Ou, Xichao, He, Ping, Zhao, Bing, Zhu, Baoli, Liu, Fei, Li, Zhiyuan, Liu, Chunfa, Xia, Hui, Wang, Shengfen, Zhou, Yang, Walker, Timothy M, Liu, Lei, Crook, Derrick W, Zhao, Yanlin. Whole-genome sequencing for surveillance of tuberculosis drug resistance and determination of resistance level in China. CLINICAL MICROBIOLOGY AND INFECTION[J]. 2022, 第 8 作者28(5): 731.e9-731.e15, http://dx.doi.org/10.1016/j.cmi.2021.09.014.
[11] 方圆, 潘元龙, 朱宝利. 人体肠道微生物组与疾病研究：现状、机遇与挑战. 协和医学杂志[J]. 2022, 第 3 作者13(5): 713-718, https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2022-0288.
[12] 史志远, 陈璐萍, 李博星, 朱宝利, 律娜, , , , , . 不同粪便DNA提取方法比较分析. 生物工程学报[J]. 2022, 第 4 作者38(9): 3542-3550, https://cjb.ijournals.cn/cjbcn/article/abstract/gc22093542?st=article_issue.
[13] 段云峰, 蔡峰, 律娜, 朱宝利. 益生菌促进胃肠道健康的机制及应用. 微生物学报[J]. 2022, 第 4 作者62(3): 836-847, https://actamicro.ijournals.cn/actamicrocn/article/abstract/20220307?st=article_issue.
[14] 范馨月, 陈璐萍, 朱金滔, 律娜, 朱宝利. 粪便样本不同保存方式对肠道菌群测序结果的影响. 微生物学报[J]. 2022, 第 5 作者62(2): 520-532, https://actamicro.ijournals.cn/actamicrocn/article/abstract/20220211?st=article_issue.
[15] Liu, Hongtao, Gao, Ping, Jia, Baoqian, Lu, Na, Zhu, Baoli, Zhang, Fuping. IBD-Associated Atg16L1T300A Polymorphism Regulates Commensal Microbiota of the Intestine. FRONTIERS IN IMMUNOLOGY[J]. 2022, 第 5 作者12: http://dx.doi.org/10.3389/fimmu.2021.772189.
[16] Zhang, Huanchang, Duan, Yunfeng, Cai, Feng, Cao, Demin, Wang, Lei, Qiao, Zhenyi, Hong, Qing, Li, Nan, Zheng, Yuanrong, Su, Miya, Liu, Zhenmin, Zhu, Baoli. Next-Generation Probiotics: Microflora Intervention to Human Diseases. BIOMED RESEARCH INTERNATIONAL. 2022, 第 12 作者  通讯作者  2022: http://dx.doi.org/10.1155/2022/5633403.
[17] 方圆, 李玭, 武微, 熊倩, 律娜, 朱宝利, 张玉梅. 分娩方式对北京地区持续母乳喂养的34周龄婴儿肠道菌群影响. 微生物学报[J]. 2021, 第 6 作者61(11): 3642-3652, https://actamicro.ijournals.cn/actamicrocn/article/abstract/20211123?st=article_issue.
[18] 李志远, 刘飞, 曹德民, 潘元龙, 律娜, 刘东鑫, 贺文从, 程城, 王亚楠, 赵雁林, 朱宝利. 结核分枝杆菌耐药相关单碱基突变的计算方法比较. 微生物学报[J]. 2021, 第 11 作者61(11): 3653-3666, https://actamicro.ijournals.cn/actamicrocn/article/abstract/20211124?st=article_issue.
[19] 李博星, 陈楠, 陶许诺, 陈璐萍, 朱宝利, 律娜. 痕量样本高通量测序文库构建. 食品安全质量检测学报[J]. 2021, 第 5 作者12(17): 6835-6842, http://lib.cqvip.com/Qikan/Article/Detail?id=7105802535.
[20] Zhang, Jindong, Liu, Jiao, Zhu, Shiwei, Fang, Yuan, Wang, Ben, Jia, Qiong, Hao, Huifeng, Kao, John Y, He, Qihua, Song, Lijin, Liu, Fei, Zhu, Baoli, Owyang, Chung, Duan, Liping. Berberine alleviates visceral hypersensitivity in rats by altering gut microbiome and suppressing spinal microglial activation. ACTA PHARMACOLOGICA SINICA[J]. 2021, 第 12 作者42(11): 1821-1833, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000616050000001.
[21] 史志远, 陈楠, 律娜, 朱宝利. 不同来源植物乳杆菌基因组的比较分析. 食品安全质量检测学报[J]. 2021, 第 4 作者12(17): 6826-6834, http://lib.cqvip.com/Qikan/Article/Detail?id=7105802534.
[22] Lyu, Na, Feng, Yuqing, Pan, Yuanlong, Huang, Hua, Liu, Yan, Xue, Chenyu, Zhu, Baoli, Hu, Yongfei. Genomic Characterization of Salmonella enterica Isolates From Retail Meat in Beijing, China. FRONTIERS IN MICROBIOLOGY[J]. 2021, 第 7 作者12: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058101/.
[23] Zhao, Ye, Li, Xuewei, Zhou, Yujing, Gao, Jin, Jiao, Yang, Zhu, Baoli, Wu, Depei, Qi, Xiaofei. Safety and Efficacy of Fecal Microbiota Transplantation for Grade IV Steroid Refractory GI-GvHD Patients: Interim Results From FMT2017002 Trial. FRONTIERS IN IMMUNOLOGY[J]. 2021, 第 6 作者12: http://dx.doi.org/10.3389/fimmu.2021.678476.
[24] Pan, Yuanlong, Fang, Yuan, Song, Xiaofeng, Lyu, Na, Chen, Luping, Feng, Yuqing, Xu, Xuebin, Zhu, Baoli, Hu, Yongfei. Co-occurrence of mcr-9, extended spectrum beta-lactamase (ESBL) and AmpC genes in a conjugative IncHI2A plasmid from a multidrug-resistant clinical isolate of Salmonella diarizonae. JOURNAL OF INFECTION. 2021, 第 8 作者82(4): 99-102, http://dx.doi.org/10.1016/j.jinf.2020.11.008.
[25] 曹德民, 宋晓峰, 朱宝利. 病毒感染性疾病与肠道微生物关系研究进展. 微生物学报[J]. 2021, 第 3 作者61(1): 13-24, https://actamicro.ijournals.cn/actamicrocn/article/abstract/20210102?st=article_issue.
[26] Wang, Yanan, Lyu, Na, Liu, Fei, Liu, William J, Bi, Yuhai, Zhang, Zewu, Ma, Sufang, Cao, Jian, Song, Xiaofeng, Wang, Aiping, Zhang, Gaiping, Hu, Yongfei, Zhu, Baoli, Gao, George Fu. More diversified antibiotic resistance genes in chickens and workers of the live poultry markets. ENVIRONMENT INTERNATIONAL[J]. 2021, 第 13 作者  通讯作者  153: https://doaj.org/article/c64e73b3f5ab46dfb8a45842383552b0.
[27] Cao, Jian, Liu, Fei, Liu, Shuli, Wang, Jun, Zhu, Baoli, Shi, Yi, Gao, George Fu. Identification of antibiotic resistance genes and associated mobile genetic elements in permafrost. SCIENCE CHINA-LIFE SCIENCES. 2021, 第 5 作者64(12): 2210-2213, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7136873&detailType=1.
[28] 袁文杰, 郭亚琼, 韩毅, 朱宝利. 非小细胞肺癌患者肠道微生物特征分析. 微生物学报[J]. 2021, 第 4 作者61(9): 2776-2790, https://actamicro.ijournals.cn/actamicrocn/article/abstract/20210913?st=article_issue.
[29] Wang, Yanan, Li, Zhiyuan, Lyu, Na, Ma, Sufang, Liu, Fei, Hu, Yongfei, Gao, George Fu, Zhu, Baoli. Comparative genomic analysis of mobile colistin resistance gene mcr-9 in Salmonella enterica. JOURNAL OF INFECTION. 2021, 第 8 作者  通讯作者  82(4): E15-E17, http://dx.doi.org/10.1016/j.jinf.2020.12.029.
[30] Liu, Qing, Li, Wei, Liu, Di, Li, Lingyan, Li, Jie, Lv, Na, Liu, Fei, Zhu, Baoli, Zhou, Yuguang, Xin, Yuhua, Dong, Xiuzhu. Light stimulates anoxic and oligotrophic growth of glacial Flavobacterium strains that produce zeaxanthin. ISME JOURNAL[J]. 2021, 第 8 作者15(6): 1844-1857, http://dx.doi.org/10.1038/s41396-020-00891-w.
[31] Cao, Demin, Liu, Weihua, Lyu, Na, Li, Boxing, Song, Weibo, Yang, Yanxiao, Zhu, Jianliang, Zhang, Zhiguo, Zhu, Baoli. Gut Mycobiota Dysbiosis in Pulmonary Tuberculosis Patients Undergoing Anti-Tuberculosis Treatment. MICROBIOLOGY SPECTRUM[J]. 2021, 第 9 作者  通讯作者  9(3): http://dx.doi.org/10.1128/Spectrum.00615-21.
[32] Chu, Hongqian, Hu, Yongfei, Zhang, Bing, Sun, Zhaogang, Zhu, Baoli. DNA Methyltransferase HsdM Induce Drug Resistance on Mycobacterium tuberculosis via Multiple Effects. ANTIBIOTICS-BASEL[J]. 2021, 第 5 作者  通讯作者  10(12):
[33] Pan, Yuanlong, Fang, Yuan, Feng, Yuqing, Lyu, Na, Chen, Luping, Li, Jing, Xu, Xuebin, Zhu, Baoli, Hu, Yongfei. Discovery of mcr-3.1 gene carried by a prophage located in a conjugative IncA/C2 plasmid from a Salmonella Choleraesuis clinical isolate. JOURNAL OF INFECTION. 2021, 第 8 作者82(3): 448-451, http://dx.doi.org/10.1016/j.jinf.2020.09.036.
[34] Li, Yong, Qi, Dandan, Zhu, Baoli, Ye, Xin. Analysis of m6A RNA Methylation-Related Genes in Liver Hepatocellular Carcinoma and Their Correlation with Survival. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2021, 第 3 作者22(3): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867233/.
[35] Wang, Qiang, Lin, Xuan, Xiang, Xiaochen, Liu, Wanxin, Fang, Ying, Chen, Haiping, Tang, Fang, Guo, Hongyan, Chen, Di, Hu, Xiafen, Wu, Qingming, Zhu, Baoli, Xia, Junbo. Oropharyngeal Probiotic ENT-K12 Prevents Respiratory Tract Infections Among Frontline Medical Staff Fighting Against COVID-19: A Pilot Study. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY[J]. 2021, 第 12 作者  通讯作者  9: http://dx.doi.org/10.3389/fbioe.2021.646184.
[36] Yuanlong Pan, Yuan Fang, Xiaofeng Song, Na Lyu, Luping Chen, Yuqing Feng, Xuebin Xu, Baoli Zhu, Yongfei Hu. Co-occurrence of mcr-9, extended spectrum β-lactamase (ESBL) and AmpC genes in a conjugative IncHI2A plasmid from a multidrug-resistant clinical isolate of Salmonella diarizonae. JOURNAL OF INFECTION. 2021, 第 8 作者82(4): 84-123, http://dx.doi.org/10.1016/j.jinf.2020.11.008.
[37] Liu, Yu, Qin, Shengtang, Feng, Ye, Song, Yilin, Lv, Na, Liu, Fei, Zhang, Xiaoming, Wang, Shuxian, Wei, Yumei, Li, Shuang, Su, Shiping, Zhang, Wanyi, Xue, Yong, Hao, Yanan, Zhu, Baoli, Ma, Jingmei, Yang, Huixia. Perturbations of gut microbiota in gestational diabetes mellitus patients induce hyperglycemia in germ-free mice. JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE[J]. 2020, 第 15 作者  通讯作者  11(6): 580-588, https://www.webofscience.com/wos/woscc/full-record/WOS:000589038900006.
[38] Xu, Xizhan, Gao, Zezheng, Yang, Fuquan, Yang, Yingying, Chen, Liang, Han, Lin, Zhao, Na, Xu, Jiayue, Wang, Xinmiao, Ma, Yue, Shu, Lian, Hu, Xiaoxi, Lyu, Na, Pan, Yuanlong, Zhu, Baoli, Zhao, Linhua, Tong, Xiaolin, Wang, Jun. Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota are Attributable to Its Key Ingredient Berberine. GENOMICS PROTEOMICS & BIOINFORMATICS[J]. 2020, 第 15 作者18(6): 721-736, http://dx.doi.org/10.1016/j.gpb.2019.09.007.
[39] Wang, Yanan, Liu, Fei, Zhu, Baoli, Gao, George Fu. Metagenomic data screening reveals the distribution of mobilized resistance genes tet(X), mcr and carbapenemase in animals and humans. JOURNAL OF INFECTION. 2020, 第 3 作者80(1): 130-132, http://dx.doi.org/10.1016/j.jinf.2019.09.003.
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