In order to get the novel detection technologies with excellent performances to meet the need of clinical investigation, disease control, food safety control, drug-abuse screening, antibioterrorims and so on, Zhou's team introduced many new materials and devices into the traditional biological technologies. 

Firstly,  the bio-application of many new materials and devices were explored, including up-converting phosphor nano-pariticle, carbon nanodot, aggregation-induced emission (AIE) material, interdigital electrode, optical fiber and so on. 

And then, a need-oriented technological system was built inculding on-site rapid detection technologies, on-site bacteria live-or-death discrimination technology, on-site automatic detection technology, real-time on-line total bacteria monitoring technology and real-time on-line total bacteria monitoring and identification technology. 

2004-06--2007-06  State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology Ph.D.
2001-08--2004-06  State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology M.S.

   

2017-10~, Institute of Process Engineering, Chinese Academy of Sciences, Professor
2015-06~2017-10, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Professor
2009-06~2015-06, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Associate Professor
2007-06~2009-06, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Assistant Professor

   

1. Aggregation-induced-emission materials with different electric charges as an artificial tongue: design, construction, and assembly with various pathogenic bacteria for effective bacterial imaging and discrimination, Guangjian, Liu, Shengnan Tian, Cuiyun Li, Guo-wen Xing and Lei Zhou, ACS Applied Materials & Interfaces, 2017, 9, 28331-28338.

2. Upconversion nanocrystals mediated lateral-flow nanoplatform for In Vitro detection, Zhiqin Liang, Xiaochen Wang, Wei Zhu, Pingping Zhang, Yongxin Yang, Chongyun Sun, Junjie Zhang, Xinrui Wang, Zheng Xu, Yong Zhao, Ruifu Yang, Suling Zhao and Lei Zhou, ACS Applied Materials & Interfaces, 2017, 2017 , 9 (4) :3497-3504.
3. A self-quenching-resistant carbon nanodot power with multicolor solid-state fluorescence for ultra-fast staining of various representative bacteria species within one minute, Yongqiang Zhang, Chunfeng Li, Yi Fan, Chengbin Wang, Ruifu Yang, Xingyuan Liu and Lei Zhou, Nanoscale, 2016, 2016 , 8 (47) :19744.
4. One-Step microwave synthesis of N-doped hydroxyl-functionalized carbon dots with ultra-High fluorescence quantum yields, Yongqiang Zhang, Xingyuan Liu, Yi Fan, Xiaoyang Guo, and Lei Zhou (co-corresponding author), Ying Lv, and Jie Lin，Nanoscale, 2016, 8, 15281-15287. 
5. Development and evaluation of an up-converting phosphor technology-based lateral flow assay for rapid and quantitative detection of aflatoxin B1 in crops，Yong Zhao, Xiao Liu, Xiaochen Wang, Chongyun Sun, Xinrui Wang, Pingping Zhang, Jingfu Qiug, Ruifu Yang and Lei Zhou, Talanta, 2016, 161, 297-303.
6. A fiber optic biosensor for specific identification of dead Escherichia coli O157:H7, Ting Liu, Yong Zhao, Zhonghuan Zhang, Pingping Zhang, Jun Li, Ruifu Yang, Changxi Yang and Lei Zhou, Sensors and Actuators B: Chemical, 2014(196), 161-167.
7. Rapid detection of abrin in foods with an up-converting phosphor technology-based lateral flow assay, Xiao Liu, Yong Zhao, Chongyun Sun, Xiaochen Wang, Xinrui Wang, Pingping Zhang, Jingfu Qiu, Ruifu Yang and Lei Zhou, Scientific Reports, 2016, 6:34926.
8. Rapid and multiplexed detection of ten foodborne pathogens by up-converting phosphor technology-based 10-channel lateral flow assay, Yong Zhao, Haoran Wang, Pingping Zhang, Chongyun Sun, Xiaochen Wang, Xinrui Wang, Ruifu Yang, Chengbin Wang and Lei Zhou，Scientific Reports, 2016, 6: 21342.
9. Development and evaluation of an up-converting phosphor technology based lateral flow assay for rapid detection of Francisella tularensis, Fei Hua, Pingping Zhang, Yong Zhao, Chunfeng Li, Chongyun Sun, Xiaochen Wang, Ruifu Yang, Chengbin Wang, Ailian Yu and Lei Zhou,Scientific Reports, 2015, 5:17178.
10. Development and evaluation of an up- converting phosphor technology-based lateral flow assay for the rapid, simultaneous detection of Vibrio cholerae serogroups O1 and O139, Min Hao, Pingping Zhang, Baisheng Li, Xiao Liu, Yong Zhao, Hailing Tan, Chongyun Sun, Xiaochen Wang, Xinrui Wang, Haiyan Qiu, Duochun Wang, Baowei Diao, Huaiqi Jing, Ruifu Yang, Biao Kan and Lei Zhou, PLoS ONE, 2017, 0179937.
11. Development and Evaluation of Up-Converting Phosphor Technology-Based Lateral Flow Assay for Quantitative Detection of NT-proBNP in Blood, Xiaoli Yang, Liping Liu, Qingfang Hao, Deyong Zou, Xiaoli Zhang, Liping Zhang, Hongmei Li, Yong Qiao, Huansheng Zhao and Lei Zhou, PLoS ONE, 2017, 0171376 .
12. Locked nucleic acid probe-based real-time PCR assay for the rapid detection of rifampin-resistant Mycobacterium tuberculosis, Yong Zhao, Guilian Li, Chongyun Sun, Chao Li, Xiaochen Wang, Haican Liu, Pingping Zhang, Xiuqin Zhao, Xinrui Wang, Yi Jiang, Ruifu Yang, Kanglin Wan, Lei Zhou, PLoS ONE, 2015, 0143444.
13. Evaluation of up-converting phosphor technology-based lateral flow strips for rapid detection of Bacillus anthracis spore, Brucella spp., and Yersinia pestis, Pingping Zhang, Xiao Liu, Chengbin Wang, Yong Zhao, Fei Hua, Chunfeng Li, Ruifu Yang and Lei Zhou, PLoS ONE 9(8): e105305.
14. A double-taper optical fiber-based radiation wave other than evanescent wave in all-fiber immunofluorescence biosensor for quantitative detection of Escherichia coli O157:H7, Zhonghuan Zhang, Fei Hua, Ting Liu, Yong Zhao, Jun Li, Ruifu Yang, Changxi Yang and Lei Zhou, PLoS ONE 9(5): e95429.

1. Hongkong patent: Immune Chromatographic Strip Disc For Multiple Analysis And Detecting Method By Using It, Lei Zhou, Zongmin Du, Ruifu Yang, Huijie Huang, Patent No.: 1138375B, Date of Patent: 2015.07.31;
2. Japanese patent: Multiassay immunochromatographic chip, Lei Zhou, Zhaobiao Guo, Ruifu Yang, Patent No.: 5775565，Date of Patent: 2015.07.10;
3. Australian patent: Multiassay immunochromatographic chip, Lei Zhou, Zhaobiao Guo, Ruifu Yang, Patent No.: AU2011291356, Date of Patent: 2015.05.28;
4. European patent (Covering United Kingdom, France, Germany, Italy and Netherlands): Immune Chromatographic Strip Disc For Multiple Analysis And Detecting Method By Using It, Lei Zhou, Zongmin Du, Ruifu Yang, Huijie Huang, Patent No.: 2120048, Date of Patent: 2015.01.28;
5. American patent: Immune Chromatographic Strip Disc For Multiple Analysis And Detecting Method By Using The Same, Lei Zhou, Zongmin Du, Ruifu Yang, Huijie Huang, Patent No.: US8920719B2, Date of Patent: 2014.10.30;
6. Hongkong patent: Multiassay immunochromatographic chip, Lei Zhou, Zhaobiao Guo, Ruifu Yang, Patent No.: HK1164044, Date of Patent: 2012.09.14;
7. Australian patent: Immune Chromatographic Strip Disc For Multiple Analysis And Detecting Method By Using It, Lei Zhou, Zongmin Du, Ruifu Yang, Huijie Huang, Patent No.: AU2007349145, Date of Patent: 2012.08.23;
8. Japanese patent: Immune Chromatographic Strip Disc For Multiple Analysis And Detecting Method By Using It, Lei Zhou, Zongmin Du, Ruifu Yang, Huijie Huang, Patent No.: JP2009-552043, Date of Patent: 2011.09.30

‍‍

New material and new device bio-application exploration based novel bio-detection and bio-monitoring technology development and industralization