General
Guizhong Zhang, Graduate advisor, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences
E-mail: gz.zhang@siat.ac.cn
Address: No. 1068, Xueyuan Avenue, Nanshan District, Guangdong Province
Postal Code: 518055
E-mail: gz.zhang@siat.ac.cn
Address: No. 1068, Xueyuan Avenue, Nanshan District, Guangdong Province
Postal Code: 518055
Research Areas
Cancer biology/Tumor immunology
Education
Experience
Work Experience
2020-01~ present, Associate Professor, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences
2015-07-2020-01, Assistant Professor, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences
2015-07-2020-01, Assistant Professor, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences
Publications
Papers
[1] Cheng, Jian, Zhang, Guizhong, Deng, Tian, Liu, Zhao, Zhang, Mengqi, Zhang, Pengchao, Adeshakin, Funmilayo O, Niu, Xiangyun, Yan, Dehong, Wan, Xiaochun, Yu, Guang. CD317 maintains proteostasis and cell survival in response to proteasome inhibitors by targeting calnexin for RACK1-mediated autophagic degradation. CELL DEATH & DISEASE[J]. 2023, 14(5): http://dx.doi.org/10.1038/s41419-023-05858-1.
[2] Dai, Liujiang, Zhang, Guizhong, Wan, Xiaochun. Network Pharmacology and Molecular Docking Analysis Reveal Insights into the Molecular Mechanism of Shengma-Gegen Decoction on Monkeypox. PATHOGENS[J]. 2022, 11(11): http://dx.doi.org/10.3390/pathogens11111342.
[3] Cheng, Jian, Liu, Zhao, Deng, Tian, Lu, Zhen, Liu, Maoxuan, Lu, Xiaoxu, Adeshakin, Funmilayo Oladunni, Yan, Dehong, Zhang, Guizhong, Wan, Xiaochun. CD317 mediates immunocytolysis resistance by RICH2/cytoskeleton-dependent membrane protection. MOLECULAR IMMUNOLOGY[J]. 2021, 129: 94-102, http://dx.doi.org/10.1016/j.molimm.2020.11.002.
[4] Adeshakin, Funmilayo O, Adeshakin, Adeleye O, Afolabi, Lukman O, Yan, Dehong, Zhang, Guizhong, Wan, Xiaochun. Mechanisms for Modulating Anoikis Resistance in Cancer and the Relevance of Metabolic Reprogramming. FRONTIERS IN ONCOLOGY[J]. 2021, 11: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039382/.
[5] Deng, Tian, Tang, Chao, Zhang, Guizhong, Wan, Xiaochun. DAMPs released by pyroptotic cells as major contributors and therapeutic targets for CAR-T-related toxicities. CELL DEATH & DISEASE[J]. 2021, 12(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838657/.
[6] 万晓春, 章桂忠, 邓湉, 陈倩. CD317在肿瘤发生发展及治疗方面的研究进展. 集成技术[J]. 2020, 9(6): 1-12, http://lib.cqvip.com/Qikan/Article/Detail?id=7103996791.
[7] Liu, Zhao, Zhang, Guizhong, Huang, Shiran, Cheng, Jian, Deng, Tian, Lu, Xiaoxu, Adeshakin, Funmilayo Oladunni, Chen, Qian, Wan, Xiaochun. Induction of apoptosis in hematological cancer cells by dorsomorphin correlates with BAD upregulation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2020, 522(3): 704-708, http://dx.doi.org/10.1016/j.bbrc.2019.11.157.
[8] Zhang, Guizhong, Cheng, Jian, Liu, Zhao, Deng, Tian, Adeshakin, Funmilayo Oladunni, Wan, Xiaochun. CD317-mediated cell cytoskeleton regulation as a novel means of tumor immune evasion. JOURNAL OF IMMUNOLOGYnull. 2020, 204(1): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000589972403143.
[9] Chen, Qian, Yan, Dehong, Zhang, Qingmei, Zhang, Guizhong, Xia, Meng, Li, Junxin, Zhan, Wugen, Shen, Enyun, Li, Zhihuan, Lin, Lilong, Chen, Youhai H, Wan, Xiaochun. Treatment of acetaminophen-induced liver failure by blocking the death checkpoint protein TRAIL. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE[J]. 2020, 1866(1): http://dx.doi.org/10.1016/j.bbadis.2019.165583.
[10] Wan, Xiaochun, Zhang, Guizhong, Huang, Shiran, Liu, Zhao, Liu, Lvyan, Lu, Zhen, Tang, Chao. Antitumor effect of metformin: what about Burkett's lymphoma?. JOURNAL OF IMMUNOLOGYnull. 2019, 202(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000524982502066.
[11] Zhang, Guizhong, Li, Xin, Chen, Qian, Li, Junxin, Ruan, Qingguo, Chen, Youhai H, Yang, Xiaolu, Wan, Xiaochun. CD317 Activates EGFR by Regulating Its Association with Lipid Rafts. CANCER RESEARCH[J]. 2019, 79(9): 2220-2231, https://www.webofscience.com/wos/woscc/full-record/WOS:000466765900015.
[12] Li, Junxin, Yang, Yang, Wang, Min, Ren, Xiaohu, Yang, Zheng, Liu, Lvyan, Zhang, Guizhong, Chen, Qian, Yang, Wei, Chen, Youhai H, Wan, Xiaochun. Rapid isolation of a potent human antibody against H7N9 influenza virus from an infected patient. ANTIVIRAL RESEARCH[J]. 2019, 170: 104564-, http://dx.doi.org/10.1016/j.antiviral.2019.104564.
[13] Chen, Qian, Wang, Pu, Zhang, Qingmei, Xia, Meng, Zhang, Guizhong, Li, Junxin, Shen, Enyun, Chen, Youhai H, Wan, Xiaochun. Preclinical studies of a death receptor 5 fusion protein that ameliorates acute liver failure. JOURNAL OF MOLECULAR MEDICINE-JMM[J]. 2019, 97(9): 1247-1261, https://www.webofscience.com/wos/woscc/full-record/WOS:000483704600004.
[14] Zhang, Guizhong, Li, Xin, Liu, Lvyan, Li, Junxin, Chen, Qian, Huang, Shiran, Li, Yutao, Wan, Xiaochun. Vaccination with a DNA vaccine encoding CD317-targeting HBs antigen elicits enhanced immunity in mice. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2018, 504(4): 865-870, http://dx.doi.org/10.1016/j.bbrc.2018.09.024.
[15] Li, Junxin, Xie, Ni, Yuan, Jianhui, Liu, Lvyan, Zhou, Qiming, Ren, Xiaohu, Chen, Qian, Zhang, Guizhong, Ruan, Qingguo, Chen, Youhai H, Wan, Xiaochun. DcR3 combined with hematological traits serves as a valuable biomarker for the diagnosis of cancer metastasis. ONCOTARGET[J]. 2017, 8(64): 107612-107620, https://www.webofscience.com/wos/woscc/full-record/WOS:000419564600024.
[16] Li, Xin, Zhang, Guizhong, Chen, Qian, Lin, Yingxue, Li, Junxin, Ruan, Qingguo, Chen, Youhai, Yu, Guang, Wan, Xiaochun. CD317 Promotes the survival of cancer cells through apoptosis-inducing factor. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH[J]. 2016, 35(1): http://dx.doi.org/10.1186/s13046-016-0391-2.
[2] Dai, Liujiang, Zhang, Guizhong, Wan, Xiaochun. Network Pharmacology and Molecular Docking Analysis Reveal Insights into the Molecular Mechanism of Shengma-Gegen Decoction on Monkeypox. PATHOGENS[J]. 2022, 11(11): http://dx.doi.org/10.3390/pathogens11111342.
[3] Cheng, Jian, Liu, Zhao, Deng, Tian, Lu, Zhen, Liu, Maoxuan, Lu, Xiaoxu, Adeshakin, Funmilayo Oladunni, Yan, Dehong, Zhang, Guizhong, Wan, Xiaochun. CD317 mediates immunocytolysis resistance by RICH2/cytoskeleton-dependent membrane protection. MOLECULAR IMMUNOLOGY[J]. 2021, 129: 94-102, http://dx.doi.org/10.1016/j.molimm.2020.11.002.
[4] Adeshakin, Funmilayo O, Adeshakin, Adeleye O, Afolabi, Lukman O, Yan, Dehong, Zhang, Guizhong, Wan, Xiaochun. Mechanisms for Modulating Anoikis Resistance in Cancer and the Relevance of Metabolic Reprogramming. FRONTIERS IN ONCOLOGY[J]. 2021, 11: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039382/.
[5] Deng, Tian, Tang, Chao, Zhang, Guizhong, Wan, Xiaochun. DAMPs released by pyroptotic cells as major contributors and therapeutic targets for CAR-T-related toxicities. CELL DEATH & DISEASE[J]. 2021, 12(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838657/.
[6] 万晓春, 章桂忠, 邓湉, 陈倩. CD317在肿瘤发生发展及治疗方面的研究进展. 集成技术[J]. 2020, 9(6): 1-12, http://lib.cqvip.com/Qikan/Article/Detail?id=7103996791.
[7] Liu, Zhao, Zhang, Guizhong, Huang, Shiran, Cheng, Jian, Deng, Tian, Lu, Xiaoxu, Adeshakin, Funmilayo Oladunni, Chen, Qian, Wan, Xiaochun. Induction of apoptosis in hematological cancer cells by dorsomorphin correlates with BAD upregulation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2020, 522(3): 704-708, http://dx.doi.org/10.1016/j.bbrc.2019.11.157.
[8] Zhang, Guizhong, Cheng, Jian, Liu, Zhao, Deng, Tian, Adeshakin, Funmilayo Oladunni, Wan, Xiaochun. CD317-mediated cell cytoskeleton regulation as a novel means of tumor immune evasion. JOURNAL OF IMMUNOLOGYnull. 2020, 204(1): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000589972403143.
[9] Chen, Qian, Yan, Dehong, Zhang, Qingmei, Zhang, Guizhong, Xia, Meng, Li, Junxin, Zhan, Wugen, Shen, Enyun, Li, Zhihuan, Lin, Lilong, Chen, Youhai H, Wan, Xiaochun. Treatment of acetaminophen-induced liver failure by blocking the death checkpoint protein TRAIL. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE[J]. 2020, 1866(1): http://dx.doi.org/10.1016/j.bbadis.2019.165583.
[10] Wan, Xiaochun, Zhang, Guizhong, Huang, Shiran, Liu, Zhao, Liu, Lvyan, Lu, Zhen, Tang, Chao. Antitumor effect of metformin: what about Burkett's lymphoma?. JOURNAL OF IMMUNOLOGYnull. 2019, 202(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000524982502066.
[11] Zhang, Guizhong, Li, Xin, Chen, Qian, Li, Junxin, Ruan, Qingguo, Chen, Youhai H, Yang, Xiaolu, Wan, Xiaochun. CD317 Activates EGFR by Regulating Its Association with Lipid Rafts. CANCER RESEARCH[J]. 2019, 79(9): 2220-2231, https://www.webofscience.com/wos/woscc/full-record/WOS:000466765900015.
[12] Li, Junxin, Yang, Yang, Wang, Min, Ren, Xiaohu, Yang, Zheng, Liu, Lvyan, Zhang, Guizhong, Chen, Qian, Yang, Wei, Chen, Youhai H, Wan, Xiaochun. Rapid isolation of a potent human antibody against H7N9 influenza virus from an infected patient. ANTIVIRAL RESEARCH[J]. 2019, 170: 104564-, http://dx.doi.org/10.1016/j.antiviral.2019.104564.
[13] Chen, Qian, Wang, Pu, Zhang, Qingmei, Xia, Meng, Zhang, Guizhong, Li, Junxin, Shen, Enyun, Chen, Youhai H, Wan, Xiaochun. Preclinical studies of a death receptor 5 fusion protein that ameliorates acute liver failure. JOURNAL OF MOLECULAR MEDICINE-JMM[J]. 2019, 97(9): 1247-1261, https://www.webofscience.com/wos/woscc/full-record/WOS:000483704600004.
[14] Zhang, Guizhong, Li, Xin, Liu, Lvyan, Li, Junxin, Chen, Qian, Huang, Shiran, Li, Yutao, Wan, Xiaochun. Vaccination with a DNA vaccine encoding CD317-targeting HBs antigen elicits enhanced immunity in mice. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2018, 504(4): 865-870, http://dx.doi.org/10.1016/j.bbrc.2018.09.024.
[15] Li, Junxin, Xie, Ni, Yuan, Jianhui, Liu, Lvyan, Zhou, Qiming, Ren, Xiaohu, Chen, Qian, Zhang, Guizhong, Ruan, Qingguo, Chen, Youhai H, Wan, Xiaochun. DcR3 combined with hematological traits serves as a valuable biomarker for the diagnosis of cancer metastasis. ONCOTARGET[J]. 2017, 8(64): 107612-107620, https://www.webofscience.com/wos/woscc/full-record/WOS:000419564600024.
[16] Li, Xin, Zhang, Guizhong, Chen, Qian, Lin, Yingxue, Li, Junxin, Ruan, Qingguo, Chen, Youhai, Yu, Guang, Wan, Xiaochun. CD317 Promotes the survival of cancer cells through apoptosis-inducing factor. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH[J]. 2016, 35(1): http://dx.doi.org/10.1186/s13046-016-0391-2.