基本信息

杜宇  研究员

硕导  

中国科学院力学研究所

电子邮件： duyu@imech.ac.cn
通信地址： 北京市海淀区北四环西路15号中科院力学所1号楼401
邮政编码： 100190

研究领域

长期致力于力学、工程科学、生物医学等多学科交叉领域的研究。利用器官芯片、微流控、类器官等前沿技术，构建三维、动态、可控的高度生理、病理相关的微生理、病理系统，研究力学/物理微环境对组织、器官功能的影响以及调控机制，解析复杂生理、病理过程及组织器官间的相互作用，为组织器官发育、疾病发病机理和药物研发评价等提供新的思路、策略和方法。


招生信息

招生专业
080101-一般力学与力学基础
招生方向

肝脏生物力学

 器官芯片

 微流控 

类器官

教育背景

2010-09--2016-07   中国科学院大学   博士
2006-09--2010-07   中国科学技术大学   学士

工作经历

2022/09~至今           中国科学院力学研究所, 项目研究员
2017/09~2022/08    宾夕法尼亚大学, 博士后
2016/07~2017/08    中国科学院力学研究所, 科研助理


发表论文及著作

  1. Du, Y., de Jong, I.E.M., Gupta, K., Waisbourd-Zinman, O., Har-Zahav, A., Soroka, C.J., Boyer, J.L., Llewellyn, J., liu, C.Y.,Naji, A., Polacheck, W.J., and Wells, R.G. (2023). Human vascularized bile duct-on-a chip: a multi-cellular micro-physiological system for studying cholestatic liver disease. Biofabrication, 16, 015004, 10.1088/1758-5090/ad0261.
  2. Li, W., Wu, Y., Hu, W., Zhou, J., Shu, X., Zhang, X., Zhang, Z., Wu, H., Du, Y., Lü, D., et al. (2023). Direct mechanical exposure initiates hepatocyte proliferation. JHEP Reports, 100905. https://doi.org/10.1016/j.jhepr.2023.100905.
  3. de Jong, I.E.M., Hunt, M.L., Chen, D., Du, Y., Llewellyn, J., Gupta, K., Li, D., Erxleben, D., Rivas, F., Hall, A.R., et al. (2023). A fetal wound healing program after intrauterine bile duct injury may contribute to biliary atresia. Journal of hepatology. 10.1016/j.jhep.2023.08.010.
  4. Du, Y., Polacheck, W.J., and Wells, R.G. (2022). Bile Duct-on-a-Chip. Methods in molecular biology (Clifton, N.J.) 2373, 57-68. 10.1007/978-1-0716-1693-2_4.
  5.  Hsu, J.C., Du, Y., Sengupta, A., Dong, Y.C., Mossburg, K.J., Bouché, M., Maidment, A.D.A., Weljie, A.M., and Cormode, D.P. (2021). Effect of Nanoparticle Synthetic Conditions on Ligand Coating Integrity and Subsequent Nano-Biointeractions. ACS Appl Mater Interfaces 13, 58401-58410. 10.1021/acsami.1c18941.
  6. Khandekar, G., Llewellyn, J., Kriegermeier, A., Waisbourd-Zinman, O., Johnson, N., Du, Y., Giwa, R., Liu, X., Kisseleva, T., Russo, P.A., et al. (2020). Coordinated development of the mouse extrahepatic bile duct: Implications for neonatal susceptibility to biliary injury. Journal of hepatology 72, 135-145. 10.1016/j.jhep.2019.08.036.
  7. Fried, S., Gilboa, D., Har-Zahav, A., Lavrut, P.M., Du, Y., Karjoo, S., Russo, P., Shamir, R., Wells, R.G., and Waisbourd-Zinman, O. (2020). Extrahepatic cholangiocyte obstruction is mediated by decreased glutathione, Wnt and Notch signaling pathways in a toxic model of biliary atresia. Scientific reports 10, 7599. 10.1038/s41598-020-64503-5.
  8. Du, Y., Khandekar, G., Llewellyn, J., Polacheck, W., Chen, C.S., and Wells, R.G. (2020). A Bile Duct-on-a-Chip With Organ-Level Functions. Hepatology (Baltimore, Md.) 71, 1350-1363. 10.1002/hep.30918.
  9. Li, W., Li, P.W., Li, N., Du, Y., Lü, S.Q., Elad, D., Long, M.A. (2020). Matrix stiffness and shear stresses modulate hepatocyte functions in a fibrotic liver sinusoidal model. American journal of physiology. Gastrointestinal and Liver Phsiology 320(3), G272-G282. 10.1152/ajpgi.00379.2019
  10. Davidson, M.D., Song, K.H., Lee, M.H., Llewellyn, J., Du, Y., Baker, B.M., Wells, R.G., and Burdick, J.A. (2019). Engineered Fibrous Networks To Investigate the Influence of Fiber Mechanics on Myofibroblast Differentiation. ACS Biomater Sci Eng 5, 3899-3908. 10.1021/acsbiomaterials.8b01276.
  11. Tong, C.F., Zhang, Y., Lü, S.Q., Li, N., Gong, Y.X., Yang, H., Feng, S.L., Du, Y., Huang, D.D., and Long, M. (2018). Binding of intercellular adhesion molecule 1 to β(2)-integrin regulates distinct cell adhesion processes on hepatic and cerebral endothelium. American journal of physiology. Cell physiology 315, C409-c421. 10.1152/ajpcell.00083.2017.
  12. Du, Y., Li, N., and Long, M. (2018). Liver sinusoid on a chip. Methods Cell Biol 146, 105-134. 10.1016/bs.mcb.2018.06.002.
  13. Yang, H., Li, N., Du, Y., Tong, C., Lü, S., Hu, J., Zhang, Y., and Long, M. (2017). Neutrophil adhesion and crawling dynamics on liver sinusoidal endothelial cells under shear flow. Experimental cell research 351, 91-99. 10.1016/j.yexcr.2017.01.002.
  14. Du, Y., Li, N., Yang, H., Luo, C., Gong, Y., Tong, C., Gao, Y., Lü, S., and Long, M. (2017). Mimicking liver sinusoidal structures and functions using a 3D-configured microfluidic chip. Lab on a chip 17, 782-794. 10.1039/c6lc01374k.
  15. Du, Y., Peng, S., Cui, Y., Lü, S., Zhang, Y., and Long, M. (2015). Combined modeling of cell aggregation and adhesion mediated by receptor–ligand interactions under shear flow. Theoretical and Applied Mechanics Letters 5, 216-221. https://doi.org/10.1016/j.taml.2015.09.004.
  16. Li, Z., Gong, Y., Sun, S., Du, Y., Lü, D., Liu, X., and Long, M. (2013). Differential regulation of stiffness, topography, and dimension of substrates in rat mesenchymal stem cells. Biomaterials 34, 7616-7625. 10.1016/j.biomaterials.2013.06.059.


科研项目

  1. AASLD Foundation/PSC Partners Seeking a Cure Pilot Research Award, “Studying Primary Sclerosing Cholangitis by Bioengineered in vitro Vascular Biliary Model”, 2020-2021
  2. 中国科学院BR计划青年项目
  3. 国家自然科学基金面上项目，“基于肝脏器官芯片研究拉伸与剪切协同调控肝脏再生的机制”2024-2027
  4. 国家级海外青年人才项目，2024-2026