基本信息
刘永宏  男  博导  中国科学院南海海洋研究所
电子邮件: yonghongliu@scsio.ac.cn
通信地址: 广州市新港西路164号
邮政编码: 510301

研究领域

主要研究领域为海洋生物活性物质的研究,以海洋天然产物化学研究为基础,以海洋生物中防治重要疾病创新药物先导结构的发现与优化为主要研究方向。主要研究内容包括:综合运用现代分离、分析技术与活性追踪相结合的方法,研究发现海洋生物中用于防治严重危害人类健康的重要疾病创新药物先导结构或目标分子;对发现的重要活性先导化合物进行系统的结构修饰或合成研究,探讨相关衍生物的结构与活性的关系,发现结构简单、活性强、毒性小的新药研究目标分子。

近年来,开展了一些海洋化学生态学研究,旨在通过海洋生物学,生态学和海洋天然产物化学等多学科的配合,从仿生学的观点,以抗污损生物附着活性筛选为导向,结合现代色谱学,现代波谱学,现代色谱-波谱联机技术,快速分离并结构确定海洋生物中的抗藤壶幼虫附着靶向化学防御物质,改构活性成分,发现生产新的抗附着先导结构,研究抗附着活性与结构关系,总结出显效基团,在此基础上进行抗其它污损生物附着活性的研究,探讨海洋生物抗附着化合物与环境竞争适应机制,揭示海洋生物的抗附着活性化合物的化学生态学作用,为研制海洋生物来源的新型无毒绿色防污剂奠定基础。

招生信息

招收推免生硕士生,联合培养相关专业博士生,硕士生若干名 。
招生博士毕业工作人员及博士后人员
招生专业
070703-海洋生物学
100701-药物化学
070321-化学生物学
招生方向
海洋天然产物化学
海洋化学生态学
海洋药物学

教育背景

1999-09--2002-08   韩国釜山大学   海洋天然药物化学专业博士
1996-09--1999-08   长春中医药大学   天然药物化学专业硕士
1992-09--1996-08   长春中医药大学   中药学学士
学历
博士研究生
学位
博士
出国学习工作
2002年9月-2003年3月 韩国釜山大学 药学大学 博士后
2003年4月-2004年3月 日本大阪大学 药学大学 博士后
2004年4月-2005年12月 葡萄牙里斯本新大学 科技学院 化学系 博士后

工作经历

2002年9月-2003年3月 韩国釜山大学 药学大学 博士后
2003年4月-2004年3月 日本大阪大学 药学大学 博士后
2004年4月-2005年12月 葡萄牙里斯本新大学 科技学院 化学系 博士后
2006年1月至今 中国科学院南海海洋研究所 研究员 博士生导师
工作简历
2014-10~现在, 中国科学院南海海洋研究所, 海洋化学学科主任
2010-10~现在, 中国科学院南海海洋研究所, 广东省海洋药物重点实验室副主任
2006-01~2011-07,中国科学院南海海洋研究所, 研究员
2004-04~2006-01,葡萄牙里斯本新大学, 博士后
2003-04~2004-03,日本大阪大学, 博士后
2002-09~2003-03,韩国釜山大学, 博士后
社会兼职
2018-11-01-2023-10-31,中国药理学会海洋药物药理专业委员会, 常务委员
2018-01-01-今,药学学报, 编委
2017-01-01-今,Chem Biodivers, 编委
2016-01-01-今,Medicinal Chemistry (SCI 收录), 编委
2016-01-01-今,《天然产物研究与开发》, 编委
2013-01-01-今,中国药学会海洋药物专业委员会, 委员
2012-10-01-2014-12-31,natural product research, 编委
2012-01-01-今,中国生物化学与分子生物学学会 海洋生物化学与分子生物学分会, 理事
2011-01-01-2014-12-31,Journal of Arthritis编委, 编委
2011-01-01-2014-12-31,Journal of Medicinal Chemistry 编委,

教授课程

生物有机化学
海洋天然药物化学

科研活动

   
科研项目
( 1 ) 海洋微生物次生代谢的生理与生态效应及其生物合成机制, 参与, 国家级, 2010-01--2014-12
( 2 ) 重要生理功能和重大疾病相关蛋白质研究公共资源库建设, 参与, 国家级, 2011-01--2015-12
( 3 ) 红树植物海芒果果实及其3株内生真菌抗海洋生物附着活性物质的发现, 主持, 国家级, 2013-01--2016-12
( 4 ) 三种南海柳珊瑚中抗MRSA新八放烷二萜的发现,构效关系及作用机制研究, 主持, 国家级, 2012-01--2015-12
( 5 ) 五株印度洋深海来源真菌中抗生物附着活性代谢产物的发现, 主持, 国家级, 2015-01--2018-12
( 6 ) 三株南海深海真菌抗结核活性代谢产物的研究, 主持, 国家级, 2018-01--2021-12
( 7 ) 广东省"特支计划"百千万工程领军人才项目, 主持, 省级, 2017-01--2019-12
( 8 ) 海洋微生物中抗肾癌靶向药物先导化合物的 筛选和挖掘, 主持, 省级, 2018-01--2020-01
( 9 ) 海洋来源船舶防污涂料关键技术研究及产业化, 参与, 省级, 2015-01--2017-01
( 10 ) 深海微生物活性物质的化学生态效应与生物合成机制, 参与, 部委级, 2013-01--2017-12
( 11 ) 海洋微生物中抗肾癌靶向药物先导化合物的筛选和挖掘, 主持, 省级, 2018-07--2022-06
参与会议
(1)Marine Sponge-associated Microorganisms Metabolites and Their Bioactivities   2018-09-25
(2)海洋微生物活性物质研究   第十届上海中医药与天然药物国际大会   2017-10-29
(3)海洋真菌毒素的研究   第19届世界毒素大会   2017-10-24
(4)海洋微生物活性物质   2015杨凌国际农业科技论坛   2016-11-05
(5)南海软珊瑚及其共生真菌活性物质的研究   第十届海峡两岸细胞生物学术研讨会   刘永宏   2014-04-18
(6)Bioactive Metabolites from the South China Sea Invertebrates   第六届韩国海洋生物技术国际研讨会    yonghong liu   2010-11-18

合作情况

出站博士后:李云秋博士,柴兴云博士,林秀萍博士, 彭燕博士, M. Fredimoses博士(印度),Kuma博士(印度)
在站博士后:徐亮博士

项目协作单位
   

指导学生

已指导学生

董光  硕士研究生  070703-海洋生物学  

黄日明  博士研究生  070702-海洋化学  

杨斌  博士研究生  070702-海洋化学  

孙见凡  博士研究生  070702-海洋化学  

胡静  硕士研究生  070702-海洋化学  

连喜平  博士研究生  070703-海洋生物学  

白志强  硕士研究生  070702-海洋化学  

钟志龙  硕士研究生  070702-海洋化学  

冼嘉韵  硕士研究生  070702-海洋化学  

艾文  博士研究生  070702-海洋化学  

李晋昇  硕士研究生  070702-海洋化学  

汤勇  硕士研究生  070702-海洋化学  

田永奇  博士研究生  070702-海洋化学  

戴昱  硕士研究生  070702-海洋化学  

庞小艳  博士研究生  070702-海洋化学  

现指导学生

郭翠  硕士研究生  070703-海洋生物学  

罗小卫  博士研究生  070703-海洋生物学  

龙洁怡  硕士研究生  070703-海洋生物学  

陈伟豪  博士研究生  070703-海洋生物学  

陈春梅  硕士研究生  070703-海洋生物学  

李坤龙  博士研究生  070703-海洋生物学  

招聘

中国科学院南海海洋研究所刘永宏研究员课题组2018年诚聘,微生物药物化学,药物化学,有机合成相关专业固定研究人员2名,药物化学/微生物学专业博士后2名,以及联合培养相关专业博士生,硕士生若干名。

本课题组隶属中国科学院南海海洋研究所,依托广东省海洋药物重点实验室和中国科学院热带海洋生物资源可持续利用重点实验室作为研究平台。主要开展海洋生物及其共附生微生物活性成分的天然产物化学和化学生态学研究。

固定人员及博士后应聘条件:

1. 拥有有机合成,天然产物化学或微生物学及其相关专业的博士学位;在所属学科领域发表过有影响的SCI论文。

2. 能够较独立地开展科研工作,中英文基础良好,能够撰写流畅的科研论文。

3. 工作勤奋,认真负责,有较强的团队协作精神。

应聘者请准备个人简历,直接与刘永宏研究员联系。

电话:(020) 89023244

地址:广州市新港西路164号

欢迎通过E-mail:yonghongliu@scsio.ac.cn 咨询。

http://lmb.scsio.ac.cn/teamshow.asp?action=74

http://sourcedb.scsio.cas.cn/cn/rck/brjh/200907/t20090716_2086066.html

发表论文

  1. Pang X, Lin X, Tian Y, Liang R, Wang J, Yang B, Zhou X, Kaliyaperumal K, Luo X, Tu Z, Liu Y*. Three new polyketides from the marine sponge-derived fungus Trichoderma sp. SCSIO41004. Natural Product Research, 2018, 32(1), 105-111.

  2. Pang X, Lin X, Wang J, Liang R, Tian Y, Salendra L, Luo X, Zhou X, Yang B, Tu Z, Liu Y*. Three new highly oxygenated sterols and one new dihydroisocoumarin from the marine sponge-derived fungus Cladosporium sp . SCSIO41007. Steroids, 2017, doi.org/10.1016/j.steroids.2017.12.001.

  3. Lei H, Lin X, Han L, Ma J, Dong K, Wang X, Zhong J, Mu Y, Liu Y, Huang X*. Polyketide derivatives from a marine-sponge-associated fungus Pestalotiopsis heterocornis. Phytochemistry, 2017, 142, 51-59.

  4. Lin X, Li K, Yang L, Peng X, Fang W, Tian X, Liu Y, Zhou X. Dereplication and targeted isolation of bioactive sulphur compound from bacteria isolated from a hydrothermal field. Natural Product Research, 2017, DOI:10.1080/14786419.2017.1399382

  5. Ju Z, Lin X, Li M, Wang y, Tian Y, Wang J, Liu J, Tu Z, Xu S*, Liu Y*. Chaetochromones A-C, Three New Polyketides from Mangrove Plant Derived Endophytic Fungus Phomopsis sp. SCSIO 41006. Chemistry & Biodiversity, 2017, 14(11), doi: 10.1002/cbdv.201700266.

  6. Li P, Liu X, Zhu H, Tang X, Shi X, Liu Y*, Li G*. Unusual Inner-Salt Guaiazulene Alkaloids and bis-Sesquiterpene from the South China Sea Gorgonian Muriceides collaris. Scientific Reports, 2017, 7, 7697. DOI:10.1038/s41598-017-08100-z

  7. Lin X, Wu Q, Yu Y, Liang Z, Liu Y, Zhou L*, Tang L*, Zhou X*. Penicilliumin B, a novel sesquiterpene methylcyclopentenedione from a deep sea-derived Penicillium strain with renoprotective activities. Scientific Reports, 2017, accept.

  8. Li Y, Wang J, He W, Lin X, Zhou X, Liu Y*. One Strain-Many Compounds Method for Production of Polyketide Metabolites Using the Sponge-Derived Fungus Arthrinium arundinis ZSDS1-F3, Chemistry of Natural Compounds, 2017, 53(2), 373-374.

  9. Lei H, Lin X, Han L, Ma J, Ma Q, Zhong J, Liu Y, Sun T, Wang J, Huang X. New Metabolites and Bioactive Chlorinated Benzophenone Derivatives Produced by a Marine-Derived Fungus Pestalotiopsis heterocornis. Marine Drugs, 2017, 15(3), DOI: 10.3390/md15030069

  10. Luo X, Lin X, Salendra L, Pang X, Dai Yu,Yang Bin, Liu Juan, Wang J, Zhou X*, Liu Y*. Isobenzofuranones and Isochromenones from the Deep-Sea Derived Fungus Leptosphaeria sp. SCSIO 41005. Marine Drugs, 2017, 15(7), DOI:10.3390/md15070204

  11. Wang J, Liang R, Liao S, Yang B, Tu Z, Lin X, Wang B, Liu Y*. Vaccinols J-S, ten new salicyloid derivatives from the marine mangrove-derived endophytic fungus Pestalotiopsis vaccinii. Fitoterapia, 2017, 120,164-170

  12. Wang J, He W, Kong F, Tian XP, Wang P, Zhou X, Liu Y*. Ochracenes A-I, Humulane-Derived Sesquiterpenoids from the Antarctic Fungus Aspergillus ochraceopetaliformis. Journal of Natural Products, 2017, 6, 1725-1733.

  13. Wang L, Wang J, Liu J, Liu Y*. Antitubercular Marine Natural Products. Current Medicinal Chemistry, 2017, 24, DOI: 10.2174/0929867324666170113120221. 

  14. Luo X, Zhou X, Lin X, Qin X, Zhang T, Wang J, Tu Z, Yang B, Liao S, Tian Y, Pang X, Kaliyaperumal K, Li JL, Tao H, Liu Y*. Antituberculosis compounds from a deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01. Natural Product Research, 2017, 31(16), 1958-1962.

  15. Liao SR, Tang Y, Xu L, Zhou XF, Wang JF, Yang B, Liu Y*. Ring-contraction from benzo[b][1,4]thiazines to benzo[d]thiazolines induced by oxygen. Tetrahedron 2017, 73(1), 98-107.

  16. Xian J, Lin X, Lu X, Wan J, Wang J, Zhou X, Ai W, Tu Z, Liu Y*. Pestalachloride E, a new chlorinated benzophenone derivative from mangrove endophytic fungus Pestalotiopsis versicolor. Chinese Journal of Antibiotics 2017, 42, 8-13.

  17. Yang B, Tao H, Qin X, Wang Z, Dong J, Lin X, Zhou X, Li J, Tu Z, Liu Y*. Aspergone, a new chromanone derivative from fungus Aspergillus sp. SCSIO41002 derived of mangrove soil sample. The Journal of Antibiotics 2017, 6, 788-790.

  18. Chen S, Wang J, Wang Z, Lin X, Zhao B, Kaliaperumal K, Liao X, Tu Z, Li J, Xu S, Liu Y*. Structurally diverse secondary metabolites from a deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001 and their biological evaluation.  Fitoterapia, 2017, 17, 71–78.

  19. He WJ, Zhou XJ, Qin XC, Mai YX, Lin X, Liao S, Yang B, Zhang T, Tu Z, Liu Y.* Quinone/hydroquinone meroterpenoids with antitubercular and cytotoxic activities produced by the sponge-derived fungus Gliomastix sp. ZSDS1-F7. Natural Product Research 2017 , 31(5), 604-609.

  20. Wang JF, Qin XC, Chen Z, Ju Z, He W, Tan Y, Zhou XJ, Tu ZC, Lu F*, Liu Y*. Two new anthraquinones with antiviral activities from the barks of Morinda citrifolia (Noni). Phytochemistry Letters, 2016, 15, 13-15.

  21. Zhao BQ, Peng S, He WJ, Liu YH, Wang JF, Zhou XJ. Antitubercular and cytotoxic tigliane-type diterpenoids from Croton tiglium. Bioorganic & Medicinal Chemistry Letters, 2016, 26(20), 49964999.

  22. Kim A, Kim MJ, Noh TH, Hong J, Liu Y, Wei XY, Jung JH*. Synthesis and antibacterial evaluation of hamacanthin B analogues. Bioorganic & Medicinal Chemistry Letters, 2016, 26(20), 5013–5017.

  23. Kim EL, Li J, Hong, J, Yoon WD, Kim HS, Liu Y, Wei X, Jung JH*. An unusual 1(10-19)abeo steroid from a jellyfish-derived fungus. Tetrahedron Letters, 2016, 57(25), 2803-2806.

  24. Wang H, Hong J, Yin J, Liu J, Liu Y, Choi JS, Jung, JH*. Paecilonic Acids A and B, Bicyclic Fatty Acids from the Jellyfish-Derived Fungus Paecilomyces variotii J08NF-1. Bioorganic & Medicinal Chemistry Letters, 2016, 26(9), 2220-2223.

  25. Xu G, Wang Z, Zhao B, Liu N, Yang S, Liu Y, Wang J*, Zhou X.* Saniculamins A and B, two new flavonoids from Sanicula lamelligera Hance inhibiting LPS-induced nitric oxide release. Phytochemistry Letters 2016, 18, 35-38.

  26. Liu J, Jung JH, Liu Y.*Antimicrobial compounds from marine invertebrates-derived microorganisms. Current Medicinal Chemistry, 2016, 23(25): 2892-2905.

  27. Chen S , Wang J , Lin X , Zhao B , Wei X , Li G , Kaliaperumal K , Liao S , Yang B , Zhou X , Liu J , Xu S , Liu Y*. Chrysamides A-C, three dimeric nitrophenyl trans-epoxyamides produced by the deep-sea-derived fungus Penicillium chrysogenum SCSIO41001. Organic Letters, 2016, 18, 3650-3653.

  28. Liao S, Qin X, Wang Z, Li D, Xu L, Li J, Tu Z, Liu Y* Design, synthesis and cytotoxic activities of novel 2,5-diketopiperazine derivatives. European Journal of Medicinal Chemistry, 2016, 121, 500-509.

  29. Wang J, Wei X, Qin X, Tian X, Liao L, Zhou X, Yang X, Wang F, Tu Z, Chen B, Liu Y.* Antiviral merosesquiterpenoids produced by an antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702. Journal of Natural Products, 2016, 79(1), 59-65.

  30. Wang J, He W, Huang X, Tian X, Liao S, Yang B, Wang F, Zhou X, Liu Y* Antifungal new oxepine-containing alkaloids and xanthones from the deep-sea-derived fungus Aspergillus versicolor SCSIO 05879. Journal of Agriculture and Food Chemistry 2016, 64, 2910-2916.

  31. Zhou X, Fang W, Tan S, Lin X, Xun T, Yang B, Liu S, Liu Y.* Aspernigrins with anti-HIV-1 activities from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30. Bioorganic & Medicinal Chemistry Letters, 2016, 26, 361-365.

  32. Tian Y, Lin X, Wang Z, Zhou X, Qin X, Kaliyaperumal K, Zhang T, Tu Z, Liu Y.* Asteltoxins with antiviral activities from the marine sponge-derived fungus Aspergillus sp. SCSIO XWS02F40. Molecules, 2016, 21(1), 34, doi:10.3390/molecules21010034

  33. Liao S , Du L, Qin X, Xu L, Wang J, Zhou X, Tu Z, Li J*, Liu Y*. Site selective synthesis of cytotoxic 1,3,6-trisubstituted 3,6-diunsaturated (3Z,6Z)-2,5-diketopiperazines via a one-pot multicomponent method. Tetrahedron, 2016, 72(8), 1051-1057.

  34. Asperpyrone-Type Bis-Naphtho--Pyrones with COX-2-Inhibitory Activities from Marine-Derived Fungus Aspergillus niger. Fang W, Lin X, Wang J, Liu Y, Tao H, Zhou X.MOLECULES, 2016, 21( 7), DOI: 10.3390/molecules21070941.

  35. Ju ZR, Qin XC, Lin XP, Wang JF, Kaliyaperumal K, Tian YQ, Liu J, Liu F, Tu ZC, Xu SH, Liu Y*. New phenyl derivatives from endophytic fungus Botryosphaeria sp SCSIO KcF6 derived of mangrove plant Kandelia candel. Natural Product Research, 2016, 30(2), 192-198.

  36. Yang B, Huang J, Lin X, Zhang Y, Tao H, Liu Y*. A new diketopiperazine from the marine sponge Callyspongia species. Records of Natural Products, 2016, 10 (1), 117-121.

  37. Yang B, Huang J, Li X, Lin X, Zhou X, Tao H, Liu Y*. Isolation, Characterization, and Bioactivity Evaluation of Alkaloids from Soft Coral Sinularia kotanianensis. Chemistry of Natural Compounds, 2016, 52(3),564-566.

  38. Tao G, Liu J, Jung JH, Guo W, Wen XQ, LiuY*. Compounds from a jellyfish-derived fungus Aspergillus fumigates. Natural Product Sciences, 2016, 22(2):82-86.

  39. Wang H, Hong J, Yin JMoon HRLiu YWei XOh DCJung JH*. Dimeric Octaketide Spiroketals from the Jellyfish-Derived Fungus Paecilomyces variotii J08NF-1. J Nat Prod. 2015,78(11):2832-2836.

  40. Wang J, Wei X, Qin X, Lin X, Zhou X, Liao S, Yang B, Liu J, Tu Z, Liu Y*. Arthpyrones A–C, Pyridone alkaloids from a sponge-derived fungus Arthrinium arundinis ZSDS1-F3. Organic Letters, 2015, 17, 656−659.

  41. Liao S, Xu Y, Tang Y, Wang J, Zhou X, Xu L, Liu Y*. Design, synthesis and biological evaluation of soluble 2,5-diketopiperazines derivatives as potential antifouling agents. RSC Advances 2015, 5, 5, 51020–51026

  42. Wang JF, He WJ, Qin XC, Wei XY, Tian XP, Liao L, Liao SR, Yang B, Tu ZC, Chen B, Wang FZ, Zhou XJ, Liu Y*. Three new indolyl diketopiperazine metabolites from the antarctic soil-derived fungus Penicillium sp SCSIO 05705. RSC Advances, 2015, 5(84), 68736-68742.

  43. Zhang J, Lin X, Li L, Zhong B, Liao X, Liu Y*, Xu S* Gliomasolides A–E, unusual macrolides from a sponge-derived fungus Gliomastix sp. ZSDS1-F7-2† RSC Advances 2015, 5, 54645–54648

  44. Bai Z, Lin X, Wang J, Zhou X, Liu J, Yang Y, Yang X, Liao S, Wang L, Liu Y.* New meroterpenoids from the endophytic fungus Aspergillus flavipes AIL8 derived from the mangrove plant Acanthus ilicifolius. Marine Drugs, 2015, 13, 237-248.

  45. Liu J, Wei X, Kim E, Lin X, Yang X, Zhou X, Yang B, Jung J, Liu Y.* New glucosidated pyrazinoquinazoline indole alkaloids from fungus Aspergillus fumigatus derived of a jellyfish. Tetrahedron, 2015, 71, 271-275. 

  46. Wang J, Wang Z, Ju Z, Wan J, Liao S,  Lin X, Zhang T, Zhou X, Chen H, Yang B, Tu Z, Liu Y.* Cytotoxic cytochalasins from marine-derived fungus Arthrinium arundinis ZSDS1-F3. Planta Medica, 2015, 81, 160-166.

  47. Li J, Huang L, Liu J, Song Y, Gao J, Jung J, Liu Y*, Chen G*. Acetylcholinesterase inhibitory dimeric indole derivatives from the marine actinomycetes Rubrobacter radiotolerans, Fitoterapia 2015, 102, 203-207.

  48. Wang JF, Yang SH, Liu YQ, Li DX, He WJ, Zhang XX, Liu Y*, Zhou XJ*. Five new phorbol esters with cytotoxic and selective anti-inflammatory activites from Croton tiglium. Bioorganic & Medicinal Chemistry Letters, 2015, 25(9), 1986-1989.

  49. Wang L, Wang J, Wang L, Ma S, Liu Y.* Anti-enterovirus 71 agents of natural products. Molecules 2015, 20(9), 16320-16333.

  50. Qin C, Lin X, Lu X, Wan J, Zhou X, Liao S, Tu Z, Xu S, Liu Y.* Sesquiterpenoids and xanthones derivatives produced by sponge-derived fungus Stachybotry sp. HH1 ZSDS1F1-2. The Journal of Antibiotics 2015, 68121-125

  51. Ai W, Lin L, Wang Z, Lu X, Mangaladoss F, Yang X, Zhou X, Tu Z, Liu Y.* Cladosporone A, a new dimeric tetralone from fungus Cladosporium sp. KcFL6’ derived of mangrove plant Kandelia candel. The Journal of Antibiotics 2015, 68, 213-215.

  52. Tian Y, Qin X, Lin X, Kumaravel K, Zhou X, Liu J, Ju Z, Tu Z, Liu Y.* Sydoxanthone C and acremolin B produced by deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01. The Journal of Antibiotics 2015, 68, 703-706.

  53. Ju ZR, Lin XP, Lu X, Tu ZC, Wang JF, Kaliyaperumal K, Liu J, Tian YQ, Xu SH  Liu Y.* Botryoisocoumarin A, a new COX-2 inhibitor from the mangrove Kandelia candel endophytic fungus Botryosphaeria sp KcF6. The Journal of Antibiotics 2015, 68, 653-656.

  54. Ai W, Lin X, Tu Z, Tian X, Lu X, Mangaladoss M, Zhong J, Liu Y.* Axinelline A, a new COX-2 inhibitor from Streptomyces axinellae SCSIO02208. Natural Product Research 2015, 68, 213-215.

  55. Tian Y, Lin X, Liu J, Kaliyaperumal K, Ai W, Ju J, Yang Y, Wang J, Yang X, Liu Y.* Ascomycotin A, a new citromycetin analogue produced by Ascomycota sp. Ind19F07 isolated from deep sea sediment. Natural Product Research 2015, 29(9), 820-826.

  56. Sun J, Yang B, Zhou X, Yang X, Wang L, Liu Y.* A new briarane-type diterpenoid from the South China Sea Gorgonian Dichotella gemmacea. Natural Product Research 2015, 29(9), 807-812.

  57. Fredimoses M, Zhou X, Ai W, Tian X, Yang B, Lin X, Xian J, Liu Y.* Westerdijkin A, a new hydroxyphenylacetic acid derivative from deep sea fungus Aspergillus westerdijkiae SCSIO 05233. Natural Product Research 2015, 29(2), 158-162.

  58. Wang J, Qin X, Xu F, Zhang T, Liao S, Lin X, Yang B, Liu J, Wang L, Tu Z, Liu Y*. Tetramic acid derivatives and polyphenols from sponge-derived fungus and their biological evaluation. Natural Product Research 2015, 29(18), 1761-1765.

  59. Yang B, Huang JX, Lin XP, Liao SR, Zhou XF, Liu J, Wang JF, Wang LS, Liu Y*. New casbane diterpenoids from the Hainan soft coral Sinularia species. Helvetica Chimica Acta, 2015, 98(6), 834-841.

  60. Wang, JF, Wei XY, Qin XC, Chen H, Lin XP, Zhang TY, Yang XW, Liao SR, Yang B, Liu J, Zhou XF, Tu ZC, Liu Y*. Two new prenylated phenols from endogenous fungus Pestalotiopsis vaccinii of mangrove plant Kandelia candel (L.) Druce. Phytochemistry Letters, 2015, 12, 59-62.

  61. Huang, RM, Chen, YN, Zhou, XF, Yang, XW, Liu, Y*. A new N-Acyl taurine from the South China Sea marine sponge Callyspongia sp. Chemistry of Natural Compounds, 2015, 51(3), 540-541.

  62. Sun J, Wu Y, Yang B, Liu Y.* Chemical constituents of marine sponge Halichondria sp. from South China Sea. Chemistry of Natural Compounds 2015, 51(5), 975-977.

  63. Wang H, Hong J, Yin J, Moon H, Liu Y, Wei X, Oh D, Jung JH. Dimeric Octaketide spiroketals from the jellyfish-derived fungus Paecilomyces variotii J08NF-1, Journal of Natural Products, 2015, 78(11), 2832-2836.

  64. Yang X, Miao Z, Ma X, Zhang G, Steinmetz A, Yang B, Wang J, Liu J, Liu Y, Wang N. Asterolloside, a novel enolic saccharide from the sea star Asterias rollestoni Bell. Tetrahedron Letters, 2015, 56, 6174-6176.

  65. Wang J, He W, Zhang X, Zhao B, Liu Y, Zhou X*. Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L. Bioorganic & Medicinal Chemistry Letters, 2015, 25, 4082-4084.

  66. Wang B, Wang L, Li Y, Liu Y*. Heterocyclic terpenes: linear furano-and pyrroloterpenoids. RSC Advances 2014, 4, 12216-12234.

  67. Lei H, Sun S, Han Z, Zhou X, Yang B, Liu Y*. Fragilisinins A-L, new briarane-type diterpenoids from gorgonian Junceella fragilis. RSC Advances 2014, 4(10), 5261-5271.

  68. Wang L, Zhou X, Fredimoses M, Liao S, Liu Y*. Naturally occurring organoiodines, RSC Advances 2014, 4 (101), 57350- 57376.

  69. Fredimoses M, Zhou X, Lin X, Tian X, Ai W, Wang W, Liao S, Liu J, Yang B, Yang X, Liu Y.* New prenylxanthones from the deep-sea derived fungus Emericella sp. SCSIO 05240. Marine Drugs 2014, 12(6), 3190-3202.

  70. Yang B, Wei X, Huang J, Lin X, Liu J, Liao S, Wang J, Zhou X, Wang L, Liu Y*. Sinulolides A-H, New Cyclopentenone and Butenolide Derivatives from Soft Coral Sinularia sp. Marine Drugs, 2014, 12(10), 5316-5327.

  71. Liao S, Qin X, Li D, Tu Z, Li J, Zhou X, Wang J, Yang B, Lin X, Liu J, Yang X, Liu Y*. Design and synthesis of novel soluble 2,5-diketopiperazine derivatives as potential anticancer agents. European Journal of Medicinal Chemistry, 2014, 83, 236-244.

72. Yang B, Dong J, Lin X, Zhou X, Zhang Y, Liu Y*. New prenylated indole alkaloids from fungus Penicillium sp. derived of mangrove soil sample. Tetrahedron, 2014, 70(25), 3859–3863.
  1. Ai W, Wei X, Lin X, Sheng L, Wang Z, Tu Z, Yang X, Zhou X, Li J, Liu Y.* Guignardins A-F, spirodioxynaphthalenes from the endophytic fungus Guignardia sp KcF8 as a new class of PTP1B and SIRT1 inhibitors. Tetrahedron, 2014, 70(35), 5806-5814.

  2. Wang J, Wei X, Lu X, Xu F, Wan J, Lin X, Zhou X, Liao S, Yang B, Tu Z, Liu Y.* Eight new polyketide metabolites from the fungus Pestalotiopsis vaccinii endogenous with the mangrove plant Kandelia candel (L.) Druce. Tetrahedron, 2014, 70, 9695-9701.

  3. Fang W, Lin X, Zhou X, Ai W, Lin J. Yang B, Tu C, Liu Y.* Cytotoxic and antiviral sesquiterpenoid nitrobenzoyl esters from the marine-derived fungus Aspergillus sp. Jcma1F17. MedChemComm 2014, 5, 701-705.

  4. Bai Z, Lin X, Wang Y, Wang J, Zhou X, Yang B, Liu J, Yang X, Wang Y, Liu Y* New phenyl derivatives from endophytic fungus Aspergillus flavipes AIL8 derived of mangrove plant Acanthus ilicifolius. Fitoterapia, 2014, 95, 194-202.

  5. Sun J, Lin X, Zhou X, Wan J, Zhang T, Yang B, Yang X, Tu Z, Liu Y*. Pestalols A-E, New Alkenyl Phenol and Benzaldehyde Derivatives from Endophytic Fungus Pestalotiopsis sp. Acbc2 Isolated from the Chinese Mangrove Plant Aegiceras corniculatum. The Journal of Antibiotics 2014, 67(6), 451-457.

  6. Wang J, Lin X, Qin Z, Liao S, Wan J, Zhang T, Liu J, Fredimoses M, Chen H, Yang Y, Zhou X, Yang X, Tu Z, Liu Y*. Antimicrobial and Antiviral Sesquiterpenoids from Sponge-Associated Fungus, Aspergillus sydowii ZSDS1-F6. The Journal of Antibiotics 2014, 67(8), 581-583. 

  7. Liao S, Qin C, Yao P, Li J, Zhou X, Wang J, Huang Z, Liu Y.* A One-Pot Synthesis of Unsaturated, Polysubstituted 3-Aminoazepan-2-ones. Synthesis 2014, 46(5), 621-628. 

  8. Yang X, Li S, Li Y, Feng L, Shen Y, Lin S, Tian J, Zeng H, Wang N, Steinmetz A, Liu Y, Zhang W. Chemical constituents of Abies delavayi. Phytochemistry, 2014, 105, 164-170.  

  9. Peng Y, Huang R, Hu J, Zhou X, Yang B, Liu L, Yang X, Liu Y*. Bioactive chemical constituents of the South China Sea starfish Stellaster equestris. Chemistry of Natural Compounds, 2014, 50(1), 184-185.

  10. Huang R, Yan T, Peng Y, Zhou X, Yang X, Liu Y. Diketopiperazines from the marine sponge Axinella sp. Chemistry of Natural Compounds, 2014, 50(1), 191-193.

  11. Wang J, Xu F, Wang Z, Lu X, Wan J, Yang B, Zhou X, Zhang T, Tu Z, Liu Y* A new naphthalene glycoside from the sponge-derived fungus Arthrinium arundinis ZSDS1-F3. Natural Product Research 2014, 28(14), 1070-1074.

  12. Yang B, Dong J, Lin X, Tao H, Zhou Z Liu Y. Xylaolide A, a new lactone from the fungus Xylariaceae sp. DPZ-SY43. Natural Product Research 201428(13), 967-970.

  13. Zhou X, Sun J, Ma W, Fang W, Chen Z, Yang B, Liu Y*. A new aromatic amine from fungus Pestalotiopsis vaccinii. Phytochemistry Letters 2014, 7, 35-37.

  14. Zhou X, Sun J, Ma W, Fang W, Chen Z, Yang B, Liu Y*. Bioactivities of six sterols isolated from marine invertebrates. Pharmaceutical Biology 2014, 52(2), 187-190.

  15. Yang B, Tao H, Zhou X, Lin X, Liu Y*. Two new alkaloids from marine sponge Callyspongia sp. Natural Product Research 2013, 27(4-5), 433-437.

  16. Wang L, Yang B, Lin X, Zhou X, Liu Y*. Sesterterpenoids, Natural Product Report 2013, 30, 455-473.

  17. Yang B, Liao S, Lin X, Wang J, Liu J, Zhou X, Yang X, Liu Y*. New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp. Marine Drugs, 2013, 11, 4747-4750.

  18. Yang X, Peng K, Liu Z, Zhang G, Li J, Wang N, Steinmetz A, Liu Y. Strepsesquitriol, a Rearranged Zizaane-Type Sesquiterpenoid from the Deep-Sea-Derived Actinomycete Streptomyces sp. SCSIO 10355.Journal of Natural Product 2013, 76, 2360-2363.

  19. Sun J, Han Z, Zhou X, Yang Y, Lin X, Liu J, Peng Y, Yang X, Liu Y*. Antifouling briarane type diterpenoids from South China Sea gorgonians Dichotella gemmacea, Tetrahedron 2013, 69, 971-880. 

  20. Zhou X, Liu J, Yang B, Lin X, Yang X, Liu Y*. Marine Natural Products with Anti-HIV Activities in the Last Decade, Current Medicinal Chemistry 2013, 20(7), 953-973. 

  21. Yang X, Zhang G, Ying J, Yang B, Zhou X, Steinmetz A, Liu Y*. Wang N. Isolation, characterization, and bioactivity evaluation of 3-((6-methylpyrazin-2-yl) methyl)-1H-indole, a new alkaloid from a deep-sea-derivated actinomycete Serinicoccus profundi sp. nov. Marine Drugs 2013, 11, 33-39.

  22. Huang RM, Peng Y, Zhou XF, Yang X, Liu Y*. A new taurine derivative from South China Sea marine sponge Axinella sp. Natural Product Research 2013, 27(17), 1537-1541. 

  23. Huang RM, Peng Y, Zhou XF, Fu MQ, Tian S, Liu Y*. A new pyrimidinedione derivative from the gorgonian coral Verrucella umbraculum. Natural Product Research 2013, 27(4-5), 319-322.

  24. Zhou X, Lin X, Guo X, Yang Y, Yang X, Liu Y*. Chemical Constituents of the Sponge Mycale Species from South China Sea, Records of Natural Products 2013, 7, 119-123.

  25. Yang B, Zhou X, Huang H, Yang X, Liu J, Lin X, Li X, Peng Y, Liu Y*. New cembrane diterpenoids from a Hainan soft coral Sinularia sp. Marine Drugs 2012, 10, 2023-2032.

  26. Yang B, Zhou X, Lin X, Liu J, Peng Y, Yang X, Liu Y*. Cembrane diterpenes chemistry and biological properties. Current Organic Chemistry 2012, 16(12), 1512-1539.

  27. Chen J, Lan X, Liu Y*, Jia A. In vitro effects of natural diketopiperazines on release of cytokines and chemokines in J774A.1 macrophages. Bioorganic Medicinal Chemistry Letter 2012, 16, 3177-3180.

  28. Lin X, Zhou X, Wang F, Liu K, Yang B, Yang X, Peng P, Liu L, Ren Z, Liu Y*. A new cytotoxic sesquiterpene quinone produced by Penicillium sp. F00120 isolated from a deep sea sediment sample. Marine Drugs 2012, 10, 106-115.

  29. Kim E, Li J, Dang H, Hong J, Lee C, Kim D, Yoon W, Kim E, Liu Y, Jung J. Cytotoxic cytochalasins from the endozoic fungus Phoma sp. of the giant jellyfish Nemopilema nomurai. Bioorganic & Medicinal Chemistry Letters 2012, 22, 3126–3129.

  30. Li W, Wang L, Zhao D, Liu Y*. Steroidal alkaloids from Veratrum nigrum L. Chemistry of Natural Compounds 2012, 48(5), 919-920.

  31. He WH, Lin L, Xu T, Jung JH, Yin H, Yang B, Liu Y*. A new norsesterterpenoid from the sponge species Sarcotragus. Chemistry of Natural Compounds 2012, 48(2), 208-210.

  32. Peng Y, Xie E, Zheng K, Fredimoses M, Yang Y, Zhou X, Wang Y, Yang B, Lin X, Liu J, Liu Y*. Nutritional and Chemical Composition and Antiviral Activity of Cultivated Seaweed Sargassum naozhouense Tseng et Lu. Marine Drugs 2013, 11, 20-32.

  33. Huang R, Wang B, Liu Y*. Briarane-type diterpenoids from the gorgonian coral Verrucella umbraculum. Chemistry of Natural Compounds 2012, 48(3), 516-517.

  34. Yang B, Hu J, Lei H, Chen XC, Zhou XF, Liu Y*. Chemical constituents of marine sponge Callyspongia sp. from the South China Sea. Chemistry of Natural Compounds 2012, 48(2), 350-351.

  35. Liao X, Tang L, Liang Y, Jian S, Xu S, Liu Y*. New pentahydroxylated steroids from the South China Sea gorgonian Subergorgia suberosa Chemistry & Biodiversity 2012, 9, 370-375.

  36. Liu Y*. Renaissance of marine natural product drug discovery and development.  Journal of Marine Science Research & Development 2012, 2, 1000e106.

  37. Sun J, Huang H, Chai X, Yang X, Meng L, Huang C, Zhou X, Yang B, Hu J, Chen X, Lei H, Wang L, Liu Y*. Dichotellides A-E, five new iodine-containing briarane type diterpenoids from Dichotella gemmacea. Tetrahedron 2011, 67, 1245-1250.

  38. Wang L, Zhao D, Di L, Xu T, Lin X, Yang B, Zhou X, Yang X, Liu Y*. The analgesic and anti-rheumatic effects of Thladiantha dubia fruit crude polysaccharide fraction in mice and rats. Journal of Ethnopharmacology 2011, 137, 1381-1387.

  39. Zhou X, Lu Y, Lin X, Yang Y, Yang X, Liu Y. Brominated aliphatic hydrocarbons and sterols from the sponge Xestospongia testudinaria with their bioactivities Chemistry and Physics of lipids 2011, 164, 703-706.

  40. Yang X, Li Y, Li S, Shen Y, Tian J, Zhu Z, Feng L, Wu, L, Lin, S, Wang, N, Liu Y, Zhang W. Mono- and sesquiterpenoids, flavonoids, lignans, and other miscellaneous compounds of Abies georgei. Planta Medica 2011, 77(7), 742-748.

  41. Wang L, Zhao D, Di L, Cheng D, Zhou X, Yang X, Liu Y*. The anti-hyperplasia of mammary gland effect of Thladiantha dubia root ethanol extract in rats reduced by estrogen and progestogen. Journal of Ethnopharmacology 2011, 134, 136-140.

  42. Yang X, Dong G, Zhou X, Chai X, Li Y, Yang B, Zhang W, Liu Y*. Isolation and structural characterisation of five new and 14 known metabolites from the commercial starfish Archaster typicus Food Chemistry 2011, 124, 1634-1638.

  43. Liu Y*, Yan H, Wen K, Zhang J, Xu T, Wang L, Zhou X, Yang X. Identification of epidioxysterol from South China Sea urchin Tripneustes gratilla Linnaeus and its cytotoxic activity. Journal of Food Biochemistry 2011, 35, 932-938.

  44. Hu J, Yang B, Lin X, Zhou X, Yang X, Long L, Liu Y*. Chemical and Biological Studies of Soft Corals Nephtheidae Family. Chemistry & Biodiversity 2011, 8, 1011-1032.

  45. Dong G, Yang X, Zhou X. Liu Y*. Chemical constituents and bioactivities of starfish. Chemistry & Biodiversity 2011, 8(5), 740-791.

  46. Huang R, Zhou X, Peng Y, Yang X, Xu T, Liu Y*. Nucleosides from the marine sponge Callyspongia sp. Chemistry of Natural Compounds 2011, 46, 1010-1011.

  47. Liu Y*, Jung J, Xu T, Long LJ, Lin XP, Yin H., Yang B, Zhou XF, Yang XW. New cyclitol derivative from a sponge Sarcotragus species. Natural Products Research 2011, 25(6), 648-652.

  48. Chai X, Sun J, Tang L, Yang X, Li Y, Huang H, Zhou X, Yang B, Liu Y*. A novel cyclopentene derivative and a polyhydroxylated steroid from a South China Sea gorgonian Menella sp. Cheimcal & Pharmaceutical Bulletin 2010, 58(10), 1391-1394.

  49. Liu J, Wang L, Zhao D, Cheng D, Xu T, Zhou X, Yang X, Liu Y*. A new lignan from Saururus chinensis. Chemistry of Natural Compounds 2010, 46(4), 631-632.

  50. Zhou X, Xu T, Yang X, Xu S, Liu Y*. Chemical and biological aspects of marine sponge of the genus Xestospongia. Chemistry & Biodiversity 2010, 7, 2201-2227.

  51. Wang L, Zhou X, Xu T, Yang X, Liu Y*. Lignans from Saururus chinensis. Chemistry of Natural Compounds 2010, 46(3), 451-452.

  52. Peng Y, Zheng J, Huang R, Wang Y, Xu T, Zhou X, Liu Q, Zeng F, Ju H, Yang X, Liu Y*. Polyhydroxysteroids and saponins from the China Sea starfish Asterina sp. and their biological activities. Chemical & Pharmaceutical Bulletin 2010, 58(6), 856-858.

  53. Zhou X, Liu Y, Tang L, Zhang P, Wu J. Chemical constituents from the roots of Actinidia chinensis. Chemistry of Natural Compounds 2010, 46(2), 308-309.

  54. Huang L, Wen K, Gao X, Liu Y*. Hypolipidemic effect of fucoidan from Laminaria japonica in hyperlipidemic rats. Pharmaceutical Biology 2010, 48(4), 422-426.

  55. Huang R, Ma W, Dong J, Zhou X, Xu T, Lee K, Yang X, Xu S, Liu Y*. A new 1,4-diazepine from South China Sea marine sponge Callyspongia species. Molecules 2010, 15, 871-877.

  56. Yang X, Li S, Wu L, Li Y, Feng L, Shen Y, Tian J, Tang J, Wang N, Liu Y, Zhang W. Abiesatrines A-J: anti-inflammatory and anti-tumor triterpenoids from Abies georgei Orr. Organic & Biomolecular Chemistry 2010, 8, 2609-2616.

  57. Ren S, Ma W, Xu T, Lin X, Yin H, Yang B, Zhou X, Yang X, Long L, Lee K, Gao Q, Liu Y*. Two novel alkaloids from the South China Sea marine sponge Dysidea sp. Journal of Antibiotics 2010, 63, 699-701.

  58. Huang R, Zhou X, Xu T, Yang X, Liu Y*. Diketopiperazines from marine organisms. Chemistry & Biodiversity 2010, 7, 2809-2829.

  59. Yang X, Li S, Li Y, Xia J, Wu L, Shen Y, Tian J, Wang N, Liu Y, Zhang W. Abiespiroside A, an Unprecedented Sesquiterpenoid Spirolactone with a 6/6/5 Ring System from Abies delavayi. European Journal of Organic Chemistry 2010, 34, 6531-6534.  

  60. Xu Y, Liu Y, Xu T, Xie S, Si Y, Liu Y, Zhou H, Liu T, Xu D. A new furostanol glycoside from Tribulus terrestris. Molecules 2010, 15, 613-618.

  61. Xu Y, Bai L, Liu Y, Xu T, Liu Y, Xie S, Si Y, Zhou H, Liu T, Xu D. A new triterpenoid saponin from Pulsatilla cernua. Molecules 2010, 15, 1891-1897.

  62. Lei H, Zhou X, Yang Y, Xu T, Yang X, Sun J, Yang Y, Hu J, Lin X, Long L, Liu Y*. Bryostatins from South China Sea bryozoan Bugula neritina L. Biochemical Systematics and Ecology 2010, 38, 1231-1233.

  63. Zhou X, Wen K, Yang X, Huang R, Dong G, Yang B, Sun J, Liu Y*. Chemical constituents from the sea urchin Glyptocidaris crenularis. Biochemical Systematics and Ecology 2010, 38, 103-105.

  64. Yang X, Feng L, Li S, Liu X, Li Y, Wu L, Shen Y, Tian J, Zhang X, Liu X, Wang N, Liu Y, Zhang, W. Isolation, structure, and bioactivities of abiesadines A–Y, twenty-five new diterpenes from Abies georgei Orr. Bioorganic Medicinal Chemistry 2010, 18, 744-754.

  65. Wang L, Cheng D, Wang H, Di L, Zhou X, Xu T, Yang X, Liu Y*. The hepatoprotective and antifibrotic effects of Saururus chinensis against carbon tetrachloride induced hepatic fibrosis in rats. Journal of Ethnopharmacology 2009, 126, 487-491. 9

  66. Wang L, Zhao D, Xu T, Zhou X, Yang X, Liu Y*. A new triterpene hexaglycoside from the bark of Kalopanax septemlobus (Thunb.) Koidz. Molecules 2009, 14, 4497-4504. 1

  67. Zhou X, Tang L, Liu Y. An isomeric mixture of novel cerebrosides isolated from Impatiens pritzellii reduces lipopolysaccharide-induced release of IL-18 from human peripheral blood mononuclear cells. Lipids 2009, 44(8), 759-763. 2

  68. Zhou X, Tang L, Zhang P, Zhao X, Pi H, Zhang Y, Ruan H, Liu Y, Wu J. The interleukin-18 inhibitory activities of echinocystic acid and its saponins from Impatiens pritzellii var. hupehensis. Zeitschrift Fur Naturforschung 2009, 64c, 369-372. 3

  69. Wang L, Zhao D, Liu Y*. GC-MS analysis of the supercritical CO2 fluid extraction of Ephedra sinica roots and its antisudorific activity. Chemistry of Natural Compounds 2009, 45(3), 434-436. 2

  70. Wang B, Dong J, Zhou X, Lee KJ, Huang R, Zhang S, Liu Y*. Nucleosides from marine sponges including known ones from Haliclona sp. Zeitschrift Fur Naturforschung 2009, 64c, 143-148. 0

  71. Wang B, Lee K, Zhang S, Jung J, Liu Y*. 2-Palmitamidoethanesulfonic acid, new aminoethylsulfonic acid derivative from marine sponge Haliclona sp. Chemistry of Natural Compounds 2009, 45(1), 137-138. 2

  72. Yang B, Dong J, Zhou X, Yang X, Lee K, Wang L, Zhang S, Liu Y*. Proline-containing dipeptides from the marine sponge a Callyspongia species. Helvetica Chimica Acta 2009, 92, 1112-1117. 8

  73. Zhou X, Xu T, Wen K, Yang X, Xu S, Liu Y*. A new N-acyl taurine from the sea urchin Glyptocidaris crenularis. Bioscience, Biotechnology and Biochemistry 2009, 74(5), 1089-1091. 7

  74. Liu Y*, Wang L, Jung J, Zhang S. Sesterterpenoids. Natural Product Reports 2007, 24(6), 1401-1429. 26

  75. Liu Y*, Zhang S, Abreu P. Heterocyclic terpenes: linear furano-and pyrroloterpenoids. Natural Product Reports 2006, 23(4), 630-651. 17

  76. Liu Y, Abreu P. Tirucallane triterpenes from the roots of Ozoroa insignis. Phytochemistry 2006, 67, 1309-1315. 6

  77. Liu Y, Mansoor T, Hong J, Lee C, Sim C, Im K, Jung J. New cytotoxic sesterterpenoids and norsesterterpenoids from two sponges of the genus Sarcotragus. Journal of Natural Products 2003, 66(11), 1451-1456. 6

  78. Liu Y, Hong J, Lee C, Im KS, Kim N, Choi J, Jung J. New cytotoxic furano- and pyrroloterpenoids from the sponge Sarcotragus species. Journal of Natural Products 2002, 65(9), 1307-1314. 4

  79. Liu Y, Bae B, Alam N, Hong J, Sim C, Lee C, Im K, Jung J. New cytotoxic sesterterpenes from the sponge Sarcotragus species. Journal of Natural Products 2001, 64(10), 1301-1304. 5

  80. Tao H, Wang L, Cui Z, Zhao D, Liu Y*. Dimeric proanthocyanidins from roots of Ephedra sinica Stapf. Planta Medica 2008, 74, 1823-1825. 4

  81. Liu Y, Lee C, Hong, J, Jung J. Cyclitol derivatives from the sponge Sarcotragus species. Bulletin of the Korean Chemical Society 2002, 23(10), 1467-1469 (ChemInform Abstract). 1

  82. Liu Y*, Jung J, Zhang S. Linear pyrrolosesterterpenes from a sponge Sarcotragus species. Biochemical Systematics and Ecology 2006, 34, 774-776.1

  83. Park Y, Liu Y, Hong J, Lee C, Cho H, Kim D, Im K, Jung J. New bromotyrosine derivatives from an association of two sponges, Jaspis wondoensis and Poecillastra wondoensis. Journal of Natural Products 2003, 66(11), 1495-1498.14

  84. Wang L, Zhao D, Cheng D, Liu Y*. ent-Sauchinone from Saururus chinensis. Heterocycles 2008, 75(5), 1241-1246. 4

  85. Wang W, Li F, Alam N, Liu Y, Hong J, Lee C, Jung J. New saponins from the starfish Certonardoa semiregularis. Journal of Natural Products 2002, 65(11), 1649-1656. 3

  86. Liu Y*, Jung J, Ji H, Zhang S. Glycerolipids from a Sarcotragus species sponge. Molecules 2006, 11, 714-719.4

  87. Liu Y*, Ji H, Zhang S, Jung J, Xu T. Trisoxazole macrolides from the sponge Sarcotragus species. Chemistry of Natural Compounds 2008, 44(1), 140-141. 1

  88. Abreu P. Liu Y, Ozoroalide, a new macrolide from Ozoroa insignis. Fitoterapia 2007, 78, 388-389. 0

  89. Yin H, Zhang S, Luo X, Liu Y. Preparative isolation and purification of two benzoxazinoid glucosides from Acanthus ilicifolius L. by high-speed counter-current chromatography. Journal of Chromatography A 2008, 1205, 177-181. 11

  90. Wang L, Zhao D, Liu Y*. Quality assessment of Veratrum nigrum L. by LC-ELSD fingerprints and LC quantitative analysis. Chromatographia 2008, 68, 961-967. 1

  91. Liu Y*, Murakami N, Wang L, Zhang S. Preparative high-performance liquid chromatography for the purification of natural acylated anthocyanins from red radish (Raphanus sativus L). Journal of Chromatographic Science 2008, 46(8), 743-746. 4

  92. Liu Y*, Ji H, Dong J, Zhang S. Lee K, Matthew S. Antioxidant alkaloid from South China Sea marine sponge Iotrochota sp. Zeitschrift Fur Naturforschung 2008, 63c, 636-638. 6

  93. Wang L, Li W, Liu Y*. Hypotensive effect and toxicology of total alkaloids and veratramine from roots and rhizomes of Veratrum nigrum L. in spontaneously hypertensive rats. Pharmazie 2008, 63(8), 606-610. 3

  94. Jiang S, Li X, Zhang L, Sun W, Dai S, Xie L, Liu Y, Lee K. Culturable actinobacteria isolated from marine sponge Iotrochota sp. Marine Biology 2008, 153(5), 945-952. 15

  95. Jiang S, Sun W, Chen M, Dai S, Zhang L, Liu Y, Lee K, Li X. Diversity of culturable actinobacteria isolated from marine sponge Haliclona sp. Antonie Van Leeuwenhoek International Journal of General and Molecular Microbiology 2007, 92(4), 405-416. 41

  96. Liu Y*, Ji H, Zhang S, Murakami N, Xu T. Structure-activity relationships of 1'- acetoxychavicol acetate homologues as new nuclear export signal inhibitors. Pharmazie 2007, 62(9), 659-662. Die Pharmazie-An International Journal of Pharmaceutical Sciences.1

  97. Liu Y*, Zhang S, Jung J, Xu T. Variabilin, a chemotaxonomic marker for the familly Irciniidae. Zeitschrift Fur Naturforschung 2007, 62c, 473-476. 1

  98. Jung J, Shinde P, Hong J, Liu Y, Sim C. Secondary metabolites from a marine sponge Discodermia calys. Biochemical Systematics and Ecology 2007, 35, 48-51. 4

  99. Liu Y*, Murakami N, Abreu P, Ji H, Zhang S. Antimalarial flavonol glycosides from Euphorbia hirta. Pharmaceutical Biology 2007, 45(4), 278-281.12

  100. Liu Y*, Jung J, Zhang S. An unsaturated ω-hydroxy methyl ester from a sponge Sarcotragus species. Chemistry of Natural Compounds 2006, 42(4), 487-488. 0

  101. Liu Y, Abreu P. Long chain alkyl and alkenyl phenols from Ozoroa insignis. Journal of the Brazilian Chemical Society 2006, 17(3), 527-536. 5

  102. Liu Y*, Jung J, Zhang S. Indole alkaloids from a sponge Sarcotragus species. Biochemical Systematics and Ecology 2006, 34(5), 453-456. 2

  103.  Liu Y, Shinde PB, Hong J, Lee C-O, Im KS, Jung JH. Trisoxazole macrolide from a marine sponge Sarctragus species. Natural Product Sciences 2005, 11(1), 50-53.

  104.  Zhao Q, Liu Y, Hong J, Lee C-O, Park JH, Lee DS, Jung JH. A new cyclitol derivatives from a sponge Stelletta species. Natural Product Sciences 2003, 9(1), 18-21.


奖励

(1) 海南省科技进步奖,一等奖,省级,2010,第15名
(2) 热带海洋生物活性物质的利用技术,二等奖,国家级,2007 第11名

(3) 吉林省科技进步奖,二等奖,省级,2011,第3名

课题组成员

杨献文副研究员
周雪峰副研究员
林秀萍助理研究员
杨斌助理研究员
刘娟助理研究员
廖升荣助理研究员
王俊峰助理研究员

专利与奖励

   
奖励信息
(1) 麻黄根等三种药材药效物质基础及制剂-麻黄根总黄酮胶囊的研究, 二等奖, 省级, 2016
(2) 小飞蓬等10种药材药效活性物质基础及制剂“小飞蓬胶囊”的研究, 二等奖, 省级, 2015
(3) 海洋极端微生物抗附着活性物质及其在涂料中的应用, 一等奖, 其他, 2014
(4) 赤苞等4种药材药效活性物质基础及制剂赤苞乳疾康胶囊的研究, 二等奖, 省级, 2014
(5) 第三届广州科技创新联盟南山奖, , 市地级, 2014
(6) 第六届“全国优秀科技工作者”, , 国家级, 2014
(7) 三白草等5种药材药效活性物质基础及制剂"消肝纤胶囊"的研究, 二等奖, 省级, 2011
(8) 海南省科技进步奖, 一等奖, 省级, 2010
(9) 热带海洋生物活性物质的利用技术, 二等奖, 国家级, 2007
专利成果
( 1 ) 一种二聚黄酮化合物及其制备方法和抗癌应用, 发明, 2010, 第 1 作者, 专利号: ZL200710032476.3
( 2 ) 一种治疗高血压的海洋药物及其制备方法和分散片 , 发明, 2009, 第 1 作者, 专利号: ZL200610124326.0
( 3 ) 一种海胆提取物及其制备方法和抗癌应用, 发明, 2010, 第 1 作者, 专利号: ZL200710032474.4
( 4 ) 1. 西松烷型二萜flexibilide或其可药用盐在制备PGC-1α抑制剂中的应用, 发明, 2012, 第 5 作者, 专利号: 2012
( 5 ) 一种来源于海绵的甾醇及其制备方法和应用, 发明, 2013, 第 2 作者, 专利号: ZL200910193049.2
( 6 ) 一种罗氏海盘车提取物在制备抗肿瘤药物中的应用, 发明, 2014, 第 1 作者, 专利号: ZL201310025115.1
( 7 ) 一种来源于海绵的甾醇及其制备方法和应用, 发明, 2014, 第 2 作者, 专利号: ZL200910193049.2
( 8 ) 一种新的链霉倍半萜三醇A及其制备方法和应用, 发明, 2014, 第 5 作者, 专利号: CN201310545938.7
( 9 ) Strepsequitriol, preparation method thereof, and application thereof, 发明, 2017, 第 5 作者, 专利号: US 9701603B2

出版信息

  1. Pang X, Lin X, Tian Y, Liang R, Wang J, Yang B, Zhou X, Kaliyaperumal K, Luo X, Tu Z, Liu Y*. Three new polyketides from the marine sponge-derived fungus Trichoderma sp. SCSIO41004. Natural Product Research, 2018, 32(1), 105-111.

  2. Pang X, Lin X, Wang J, Liang R, Tian Y, Salendra L, Luo X, Zhou X, Yang B, Tu Z, Liu Y*. Three new highly oxygenated sterols and one new dihydroisocoumarin from the marine sponge-derived fungus Cladosporium sp . SCSIO41007. Steroids, 2017, doi.org/10.1016/j.steroids.2017.12.001.

  3. Lei H, Lin X, Han L, Ma J, Dong K, Wang X, Zhong J, Mu Y, Liu Y, Huang X*. Polyketide derivatives from a marine-sponge-associated fungus Pestalotiopsis heterocornis. Phytochemistry, 2017, 142, 51-59.

  4. Lin X, Li K, Yang L, Peng X, Fang W, Tian X, Liu Y, Zhou X. Dereplication and targeted isolation of bioactive sulphur compound from bacteria isolated from a hydrothermal field. Natural Product Research, 2017, DOI:10.1080/14786419.2017.1399382

  5. Ju Z, Lin X, Li M, Wang y, Tian Y, Wang J, Liu J, Tu Z, Xu S*, Liu Y*. Chaetochromones A-C, Three New Polyketides from Mangrove Plant Derived Endophytic Fungus Phomopsis sp. SCSIO 41006. Chemistry & Biodiversity, 2017, 14(11), doi: 10.1002/cbdv.201700266.

  6. Li P, Liu X, Zhu H, Tang X, Shi X, Liu Y*, Li G*. Unusual Inner-Salt Guaiazulene Alkaloids and bis-Sesquiterpene from the South China Sea Gorgonian Muriceides collaris. Scientific Reports, 2017, 7, 7697. DOI:10.1038/s41598-017-08100-z

  7. Lin X, Wu Q, Yu Y, Liang Z, Liu Y, Zhou L*, Tang L*, Zhou X*. Penicilliumin B, a novel sesquiterpene methylcyclopentenedione from a deep sea-derived Penicillium strain with renoprotective activities. Scientific Reports, 2017, accept.

  8. Li Y, Wang J, He W, Lin X, Zhou X, Liu Y*. One Strain-Many Compounds Method for Production of Polyketide Metabolites Using the Sponge-Derived Fungus Arthrinium arundinis ZSDS1-F3, Chemistry of Natural Compounds, 2017, 53(2), 373-374.

  9. Lei H, Lin X, Han L, Ma J, Ma Q, Zhong J, Liu Y, Sun T, Wang J, Huang X. New Metabolites and Bioactive Chlorinated Benzophenone Derivatives Produced by a Marine-Derived Fungus Pestalotiopsis heterocornis. Marine Drugs, 2017, 15(3), DOI: 10.3390/md15030069

  10. Luo X, Lin X, Salendra L, Pang X, Dai Yu,Yang Bin, Liu Juan, Wang J, Zhou X*, Liu Y*. Isobenzofuranones and Isochromenones from the Deep-Sea Derived Fungus Leptosphaeria sp. SCSIO 41005. Marine Drugs, 2017, 15(7), DOI:10.3390/md15070204

  11. Wang J, Liang R, Liao S, Yang B, Tu Z, Lin X, Wang B, Liu Y*. Vaccinols J-S, ten new salicyloid derivatives from the marine mangrove-derived endophytic fungus Pestalotiopsis vaccinii. Fitoterapia, 2017, 120,164-170

  12. Wang J, He W, Kong F, Tian XP, Wang P, Zhou X, Liu Y*. Ochracenes A-I, Humulane-Derived Sesquiterpenoids from the Antarctic Fungus Aspergillus ochraceopetaliformis. Journal of Natural Products, 2017, 6, 1725-1733.

  13. Wang L, Wang J, Liu J, Liu Y*. Antitubercular Marine Natural Products. Current Medicinal Chemistry, 2017, 24, DOI: 10.2174/0929867324666170113120221. 

  14. Luo X, Zhou X, Lin X, Qin X, Zhang T, Wang J, Tu Z, Yang B, Liao S, Tian Y, Pang X, Kaliyaperumal K, Li JL, Tao H, Liu Y*. Antituberculosis compounds from a deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01. Natural Product Research, 2017, 31(16), 1958-1962.

  15. Liao SR, Tang Y, Xu L, Zhou XF, Wang JF, Yang B, Liu Y*. Ring-contraction from benzo[b][1,4]thiazines to benzo[d]thiazolines induced by oxygen. Tetrahedron 2017, 73(1), 98-107.

  16. Xian J, Lin X, Lu X, Wan J, Wang J, Zhou X, Ai W, Tu Z, Liu Y*. Pestalachloride E, a new chlorinated benzophenone derivative from mangrove endophytic fungus Pestalotiopsis versicolor. Chinese Journal of Antibiotics 2017, 42, 8-13.

  17. Yang B, Tao H, Qin X, Wang Z, Dong J, Lin X, Zhou X, Li J, Tu Z, Liu Y*. Aspergone, a new chromanone derivative from fungus Aspergillus sp. SCSIO41002 derived of mangrove soil sample. The Journal of Antibiotics 2017, 6, 788-790.

  18. Chen S, Wang J, Wang Z, Lin X, Zhao B, Kaliaperumal K, Liao X, Tu Z, Li J, Xu S, Liu Y*. Structurally diverse secondary metabolites from a deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001 and their biological evaluation.  Fitoterapia, 2017, 17, 71–78.

  19. He WJ, Zhou XJ, Qin XC, Mai YX, Lin X, Liao S, Yang B, Zhang T, Tu Z, Liu Y.* Quinone/hydroquinone meroterpenoids with antitubercular and cytotoxic activities produced by the sponge-derived fungus Gliomastix sp. ZSDS1-F7. Natural Product Research 2017 , 31(5), 604-609.

  20. Wang JF, Qin XC, Chen Z, Ju Z, He W, Tan Y, Zhou XJ, Tu ZC, Lu F*, Liu Y*. Two new anthraquinones with antiviral activities from the barks of Morinda citrifolia (Noni). Phytochemistry Letters, 2016, 15, 13-15.

  21. Zhao BQ, Peng S, He WJ, Liu YH, Wang JF, Zhou XJ. Antitubercular and cytotoxic tigliane-type diterpenoids from Croton tiglium. Bioorganic & Medicinal Chemistry Letters, 2016, 26(20), 49964999.

  22. Kim A, Kim MJ, Noh TH, Hong J, Liu Y, Wei XY, Jung JH*. Synthesis and antibacterial evaluation of hamacanthin B analogues. Bioorganic & Medicinal Chemistry Letters, 2016, 26(20), 5013–5017.

  23. Kim EL, Li J, Hong, J, Yoon WD, Kim HS, Liu Y, Wei X, Jung JH*. An unusual 1(10-19)abeo steroid from a jellyfish-derived fungus. Tetrahedron Letters, 2016, 57(25), 2803-2806.

  24. Wang H, Hong J, Yin J, Liu J, Liu Y, Choi JS, Jung, JH*. Paecilonic Acids A and B, Bicyclic Fatty Acids from the Jellyfish-Derived Fungus Paecilomyces variotii J08NF-1. Bioorganic & Medicinal Chemistry Letters, 2016, 26(9), 2220-2223.

  25. Xu G, Wang Z, Zhao B, Liu N, Yang S, Liu Y, Wang J*, Zhou X.* Saniculamins A and B, two new flavonoids from Sanicula lamelligera Hance inhibiting LPS-induced nitric oxide release. Phytochemistry Letters 2016, 18, 35-38.

  26. Liu J, Jung JH, Liu Y.*Antimicrobial compounds from marine invertebrates-derived microorganisms. Current Medicinal Chemistry, 2016, 23(25): 2892-2905.

  27. Chen S , Wang J , Lin X , Zhao B , Wei X , Li G , Kaliaperumal K , Liao S , Yang B , Zhou X , Liu J , Xu S , Liu Y*. Chrysamides A-C, three dimeric nitrophenyl trans-epoxyamides produced by the deep-sea-derived fungus Penicillium chrysogenum SCSIO41001. Organic Letters, 2016, 18, 3650-3653.

  28. Liao S, Qin X, Wang Z, Li D, Xu L, Li J, Tu Z, Liu Y* Design, synthesis and cytotoxic activities of novel 2,5-diketopiperazine derivatives. European Journal of Medicinal Chemistry, 2016, 121, 500-509.

  29. Wang J, Wei X, Qin X, Tian X, Liao L, Zhou X, Yang X, Wang F, Tu Z, Chen B, Liu Y.* Antiviral merosesquiterpenoids produced by an antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702. Journal of Natural Products, 2016, 79(1), 59-65.

  30. Wang J, He W, Huang X, Tian X, Liao S, Yang B, Wang F, Zhou X, Liu Y* Antifungal new oxepine-containing alkaloids and xanthones from the deep-sea-derived fungus Aspergillus versicolor SCSIO 05879. Journal of Agriculture and Food Chemistry 2016, 64, 2910-2916.

  31. Zhou X, Fang W, Tan S, Lin X, Xun T, Yang B, Liu S, Liu Y.* Aspernigrins with anti-HIV-1 activities from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30. Bioorganic & Medicinal Chemistry Letters, 2016, 26, 361-365.

  32. Tian Y, Lin X, Wang Z, Zhou X, Qin X, Kaliyaperumal K, Zhang T, Tu Z, Liu Y.* Asteltoxins with antiviral activities from the marine sponge-derived fungus Aspergillus sp. SCSIO XWS02F40. Molecules, 2016, 21(1), 34, doi:10.3390/molecules21010034

  33. Liao S , Du L, Qin X, Xu L, Wang J, Zhou X, Tu Z, Li J*, Liu Y*. Site selective synthesis of cytotoxic 1,3,6-trisubstituted 3,6-diunsaturated (3Z,6Z)-2,5-diketopiperazines via a one-pot multicomponent method. Tetrahedron, 2016, 72(8), 1051-1057.

  34. Asperpyrone-Type Bis-Naphtho--Pyrones with COX-2-Inhibitory Activities from Marine-Derived Fungus Aspergillus niger. Fang W, Lin X, Wang J, Liu Y, Tao H, Zhou X.MOLECULES, 2016, 21( 7), DOI: 10.3390/molecules21070941.

  35. Ju ZR, Qin XC, Lin XP, Wang JF, Kaliyaperumal K, Tian YQ, Liu J, Liu F, Tu ZC, Xu SH, Liu Y*. New phenyl derivatives from endophytic fungus Botryosphaeria sp SCSIO KcF6 derived of mangrove plant Kandelia candel. Natural Product Research, 2016, 30(2), 192-198.

  36. Yang B, Huang J, Lin X, Zhang Y, Tao H, Liu Y*. A new diketopiperazine from the marine sponge Callyspongia species. Records of Natural Products, 2016, 10 (1), 117-121.

  37. Yang B, Huang J, Li X, Lin X, Zhou X, Tao H, Liu Y*. Isolation, Characterization, and Bioactivity Evaluation of Alkaloids from Soft Coral Sinularia kotanianensis. Chemistry of Natural Compounds, 2016, 52(3),564-566.

  38. Tao G, Liu J, Jung JH, Guo W, Wen XQ, LiuY*. Compounds from a jellyfish-derived fungus Aspergillus fumigates. Natural Product Sciences, 2016, 22(2):82-86.

  39. Wang H, Hong J, Yin JMoon HRLiu YWei XOh DCJung JH*. Dimeric Octaketide Spiroketals from the Jellyfish-Derived Fungus Paecilomyces variotii J08NF-1. J Nat Prod. 2015,78(11):2832-2836.

  40. Wang J, Wei X, Qin X, Lin X, Zhou X, Liao S, Yang B, Liu J, Tu Z, Liu Y*. Arthpyrones A–C, Pyridone alkaloids from a sponge-derived fungus Arthrinium arundinis ZSDS1-F3. Organic Letters, 2015, 17, 656−659.

  41. Liao S, Xu Y, Tang Y, Wang J, Zhou X, Xu L, Liu Y*. Design, synthesis and biological evaluation of soluble 2,5-diketopiperazines derivatives as potential antifouling agents. RSC Advances 2015, 5, 5, 51020–51026

  42. Wang JF, He WJ, Qin XC, Wei XY, Tian XP, Liao L, Liao SR, Yang B, Tu ZC, Chen B, Wang FZ, Zhou XJ, Liu Y*. Three new indolyl diketopiperazine metabolites from the antarctic soil-derived fungus Penicillium sp SCSIO 05705. RSC Advances, 2015, 5(84), 68736-68742.

  43. Zhang J, Lin X, Li L, Zhong B, Liao X, Liu Y*, Xu S* Gliomasolides A–E, unusual macrolides from a sponge-derived fungus Gliomastix sp. ZSDS1-F7-2† RSC Advances 2015, 5, 54645–54648

  44. Bai Z, Lin X, Wang J, Zhou X, Liu J, Yang Y, Yang X, Liao S, Wang L, Liu Y.* New meroterpenoids from the endophytic fungus Aspergillus flavipes AIL8 derived from the mangrove plant Acanthus ilicifolius. Marine Drugs, 2015, 13, 237-248.

  45. Liu J, Wei X, Kim E, Lin X, Yang X, Zhou X, Yang B, Jung J, Liu Y.* New glucosidated pyrazinoquinazoline indole alkaloids from fungus Aspergillus fumigatus derived of a jellyfish. Tetrahedron, 2015, 71, 271-275. 

  46. Wang J, Wang Z, Ju Z, Wan J, Liao S,  Lin X, Zhang T, Zhou X, Chen H, Yang B, Tu Z, Liu Y.* Cytotoxic cytochalasins from marine-derived fungus Arthrinium arundinis ZSDS1-F3. Planta Medica, 2015, 81, 160-166.

  47. Li J, Huang L, Liu J, Song Y, Gao J, Jung J, Liu Y*, Chen G*. Acetylcholinesterase inhibitory dimeric indole derivatives from the marine actinomycetes Rubrobacter radiotolerans, Fitoterapia 2015, 102, 203-207.

  48. Wang JF, Yang SH, Liu YQ, Li DX, He WJ, Zhang XX, Liu Y*, Zhou XJ*. Five new phorbol esters with cytotoxic and selective anti-inflammatory activites from Croton tiglium. Bioorganic & Medicinal Chemistry Letters, 2015, 25(9), 1986-1989.

  49. Wang L, Wang J, Wang L, Ma S, Liu Y.* Anti-enterovirus 71 agents of natural products. Molecules 2015, 20(9), 16320-16333.

  50. Qin C, Lin X, Lu X, Wan J, Zhou X, Liao S, Tu Z, Xu S, Liu Y.* Sesquiterpenoids and xanthones derivatives produced by sponge-derived fungus Stachybotry sp. HH1 ZSDS1F1-2. The Journal of Antibiotics 2015, 68121-125

  51. Ai W, Lin L, Wang Z, Lu X, Mangaladoss F, Yang X, Zhou X, Tu Z, Liu Y.* Cladosporone A, a new dimeric tetralone from fungus Cladosporium sp. KcFL6’ derived of mangrove plant Kandelia candel. The Journal of Antibiotics 2015, 68, 213-215.

  52. Tian Y, Qin X, Lin X, Kumaravel K, Zhou X, Liu J, Ju Z, Tu Z, Liu Y.* Sydoxanthone C and acremolin B produced by deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01. The Journal of Antibiotics 2015, 68, 703-706.

  53. Ju ZR, Lin XP, Lu X, Tu ZC, Wang JF, Kaliyaperumal K, Liu J, Tian YQ, Xu SH  Liu Y.* Botryoisocoumarin A, a new COX-2 inhibitor from the mangrove Kandelia candel endophytic fungus Botryosphaeria sp KcF6. The Journal of Antibiotics 2015, 68, 653-656.

  54. Ai W, Lin X, Tu Z, Tian X, Lu X, Mangaladoss M, Zhong J, Liu Y.* Axinelline A, a new COX-2 inhibitor from Streptomyces axinellae SCSIO02208. Natural Product Research 2015, 68, 213-215.

  55. Tian Y, Lin X, Liu J, Kaliyaperumal K, Ai W, Ju J, Yang Y, Wang J, Yang X, Liu Y.* Ascomycotin A, a new citromycetin analogue produced by Ascomycota sp. Ind19F07 isolated from deep sea sediment. Natural Product Research 2015, 29(9), 820-826.

  56. Sun J, Yang B, Zhou X, Yang X, Wang L, Liu Y.* A new briarane-type diterpenoid from the South China Sea Gorgonian Dichotella gemmacea. Natural Product Research 2015, 29(9), 807-812.

  57. Fredimoses M, Zhou X, Ai W, Tian X, Yang B, Lin X, Xian J, Liu Y.* Westerdijkin A, a new hydroxyphenylacetic acid derivative from deep sea fungus Aspergillus westerdijkiae SCSIO 05233. Natural Product Research 2015, 29(2), 158-162.

  58. Wang J, Qin X, Xu F, Zhang T, Liao S, Lin X, Yang B, Liu J, Wang L, Tu Z, Liu Y*. Tetramic acid derivatives and polyphenols from sponge-derived fungus and their biological evaluation. Natural Product Research 2015, 29(18), 1761-1765.

  59. Yang B, Huang JX, Lin XP, Liao SR, Zhou XF, Liu J, Wang JF, Wang LS, Liu Y*. New casbane diterpenoids from the Hainan soft coral Sinularia species. Helvetica Chimica Acta, 2015, 98(6), 834-841.

  60. Wang, JF, Wei XY, Qin XC, Chen H, Lin XP, Zhang TY, Yang XW, Liao SR, Yang B, Liu J, Zhou XF, Tu ZC, Liu Y*. Two new prenylated phenols from endogenous fungus Pestalotiopsis vaccinii of mangrove plant Kandelia candel (L.) Druce. Phytochemistry Letters, 2015, 12, 59-62.

  61. Huang, RM, Chen, YN, Zhou, XF, Yang, XW, Liu, Y*. A new N-Acyl taurine from the South China Sea marine sponge Callyspongia sp. Chemistry of Natural Compounds, 2015, 51(3), 540-541.

  62. Sun J, Wu Y, Yang B, Liu Y.* Chemical constituents of marine sponge Halichondria sp. from South China Sea. Chemistry of Natural Compounds 2015, 51(5), 975-977.

  63. Wang H, Hong J, Yin J, Moon H, Liu Y, Wei X, Oh D, Jung JH. Dimeric Octaketide spiroketals from the jellyfish-derived fungus Paecilomyces variotii J08NF-1, Journal of Natural Products, 2015, 78(11), 2832-2836.

  64. Yang X, Miao Z, Ma X, Zhang G, Steinmetz A, Yang B, Wang J, Liu J, Liu Y, Wang N. Asterolloside, a novel enolic saccharide from the sea star Asterias rollestoni Bell. Tetrahedron Letters, 2015, 56, 6174-6176.

  65. Wang J, He W, Zhang X, Zhao B, Liu Y, Zhou X*. Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L. Bioorganic & Medicinal Chemistry Letters, 2015, 25, 4082-4084.

  66. Wang B, Wang L, Li Y, Liu Y*. Heterocyclic terpenes: linear furano-and pyrroloterpenoids. RSC Advances 2014, 4, 12216-12234.

  67. Lei H, Sun S, Han Z, Zhou X, Yang B, Liu Y*. Fragilisinins A-L, new briarane-type diterpenoids from gorgonian Junceella fragilis. RSC Advances 2014, 4(10), 5261-5271.

  68. Wang L, Zhou X, Fredimoses M, Liao S, Liu Y*. Naturally occurring organoiodines, RSC Advances 2014, 4 (101), 57350- 57376.

  69. Fredimoses M, Zhou X, Lin X, Tian X, Ai W, Wang W, Liao S, Liu J, Yang B, Yang X, Liu Y.* New prenylxanthones from the deep-sea derived fungus Emericella sp. SCSIO 05240. Marine Drugs 2014, 12(6), 3190-3202.

  70. Yang B, Wei X, Huang J, Lin X, Liu J, Liao S, Wang J, Zhou X, Wang L, Liu Y*. Sinulolides A-H, New Cyclopentenone and Butenolide Derivatives from Soft Coral Sinularia sp. Marine Drugs, 2014, 12(10), 5316-5327.

  71. Liao S, Qin X, Li D, Tu Z, Li J, Zhou X, Wang J, Yang B, Lin X, Liu J, Yang X, Liu Y*. Design and synthesis of novel soluble 2,5-diketopiperazine derivatives as potential anticancer agents. European Journal of Medicinal Chemistry, 2014, 83, 236-244.

72. Yang B, Dong J, Lin X, Zhou X, Zhang Y, Liu Y*. New prenylated indole alkaloids from fungus Penicillium sp. derived of mangrove soil sample. Tetrahedron, 2014, 70(25), 3859–3863.
  1. Ai W, Wei X, Lin X, Sheng L, Wang Z, Tu Z, Yang X, Zhou X, Li J, Liu Y.* Guignardins A-F, spirodioxynaphthalenes from the endophytic fungus Guignardia sp KcF8 as a new class of PTP1B and SIRT1 inhibitors. Tetrahedron, 2014, 70(35), 5806-5814.

  2. Wang J, Wei X, Lu X, Xu F, Wan J, Lin X, Zhou X, Liao S, Yang B, Tu Z, Liu Y.* Eight new polyketide metabolites from the fungus Pestalotiopsis vaccinii endogenous with the mangrove plant Kandelia candel (L.) Druce. Tetrahedron, 2014, 70, 9695-9701.

  3. Fang W, Lin X, Zhou X, Ai W, Lin J. Yang B, Tu C, Liu Y.* Cytotoxic and antiviral sesquiterpenoid nitrobenzoyl esters from the marine-derived fungus Aspergillus sp. Jcma1F17. MedChemComm 2014, 5, 701-705.

  4. Bai Z, Lin X, Wang Y, Wang J, Zhou X, Yang B, Liu J, Yang X, Wang Y, Liu Y* New phenyl derivatives from endophytic fungus Aspergillus flavipes AIL8 derived of mangrove plant Acanthus ilicifolius. Fitoterapia, 2014, 95, 194-202.

  5. Sun J, Lin X, Zhou X, Wan J, Zhang T, Yang B, Yang X, Tu Z, Liu Y*. Pestalols A-E, New Alkenyl Phenol and Benzaldehyde Derivatives from Endophytic Fungus Pestalotiopsis sp. Acbc2 Isolated from the Chinese Mangrove Plant Aegiceras corniculatum. The Journal of Antibiotics 2014, 67(6), 451-457.

  6. Wang J, Lin X, Qin Z, Liao S, Wan J, Zhang T, Liu J, Fredimoses M, Chen H, Yang Y, Zhou X, Yang X, Tu Z, Liu Y*. Antimicrobial and Antiviral Sesquiterpenoids from Sponge-Associated Fungus, Aspergillus sydowii ZSDS1-F6. The Journal of Antibiotics 2014, 67(8), 581-583. 

  7. Liao S, Qin C, Yao P, Li J, Zhou X, Wang J, Huang Z, Liu Y.* A One-Pot Synthesis of Unsaturated, Polysubstituted 3-Aminoazepan-2-ones. Synthesis 2014, 46(5), 621-628. 

  8. Yang X, Li S, Li Y, Feng L, Shen Y, Lin S, Tian J, Zeng H, Wang N, Steinmetz A, Liu Y, Zhang W. Chemical constituents of Abies delavayi. Phytochemistry, 2014, 105, 164-170.  

  9. Peng Y, Huang R, Hu J, Zhou X, Yang B, Liu L, Yang X, Liu Y*. Bioactive chemical constituents of the South China Sea starfish Stellaster equestris. Chemistry of Natural Compounds, 2014, 50(1), 184-185.

  10. Huang R, Yan T, Peng Y, Zhou X, Yang X, Liu Y. Diketopiperazines from the marine sponge Axinella sp. Chemistry of Natural Compounds, 2014, 50(1), 191-193.

  11. Wang J, Xu F, Wang Z, Lu X, Wan J, Yang B, Zhou X, Zhang T, Tu Z, Liu Y* A new naphthalene glycoside from the sponge-derived fungus Arthrinium arundinis ZSDS1-F3. Natural Product Research 2014, 28(14), 1070-1074.

  12. Yang B, Dong J, Lin X, Tao H, Zhou Z Liu Y. Xylaolide A, a new lactone from the fungus Xylariaceae sp. DPZ-SY43. Natural Product Research 201428(13), 967-970.

  13. Zhou X, Sun J, Ma W, Fang W, Chen Z, Yang B, Liu Y*. A new aromatic amine from fungus Pestalotiopsis vaccinii. Phytochemistry Letters 2014, 7, 35-37.

  14. Zhou X, Sun J, Ma W, Fang W, Chen Z, Yang B, Liu Y*. Bioactivities of six sterols isolated from marine invertebrates. Pharmaceutical Biology 2014, 52(2), 187-190.

  15. Yang B, Tao H, Zhou X, Lin X, Liu Y*. Two new alkaloids from marine sponge Callyspongia sp. Natural Product Research 2013, 27(4-5), 433-437.

  16. Wang L, Yang B, Lin X, Zhou X, Liu Y*. Sesterterpenoids, Natural Product Report 2013, 30, 455-473.

  17. Yang B, Liao S, Lin X, Wang J, Liu J, Zhou X, Yang X, Liu Y*. New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp. Marine Drugs, 2013, 11, 4747-4750.

  18. Yang X, Peng K, Liu Z, Zhang G, Li J, Wang N, Steinmetz A, Liu Y. Strepsesquitriol, a Rearranged Zizaane-Type Sesquiterpenoid from the Deep-Sea-Derived Actinomycete Streptomyces sp. SCSIO 10355.Journal of Natural Product 2013, 76, 2360-2363.

  19. Sun J, Han Z, Zhou X, Yang Y, Lin X, Liu J, Peng Y, Yang X, Liu Y*. Antifouling briarane type diterpenoids from South China Sea gorgonians Dichotella gemmacea, Tetrahedron 2013, 69, 971-880. 

  20. Zhou X, Liu J, Yang B, Lin X, Yang X, Liu Y*. Marine Natural Products with Anti-HIV Activities in the Last Decade, Current Medicinal Chemistry 2013, 20(7), 953-973. 

  21. Yang X, Zhang G, Ying J, Yang B, Zhou X, Steinmetz A, Liu Y*. Wang N. Isolation, characterization, and bioactivity evaluation of 3-((6-methylpyrazin-2-yl) methyl)-1H-indole, a new alkaloid from a deep-sea-derivated actinomycete Serinicoccus profundi sp. nov. Marine Drugs 2013, 11, 33-39.

  22. Huang RM, Peng Y, Zhou XF, Yang X, Liu Y*. A new taurine derivative from South China Sea marine sponge Axinella sp. Natural Product Research 2013, 27(17), 1537-1541. 

  23. Huang RM, Peng Y, Zhou XF, Fu MQ, Tian S, Liu Y*. A new pyrimidinedione derivative from the gorgonian coral Verrucella umbraculum. Natural Product Research 2013, 27(4-5), 319-322.

  24. Zhou X, Lin X, Guo X, Yang Y, Yang X, Liu Y*. Chemical Constituents of the Sponge Mycale Species from South China Sea, Records of Natural Products 2013, 7, 119-123.

  25. Yang B, Zhou X, Huang H, Yang X, Liu J, Lin X, Li X, Peng Y, Liu Y*. New cembrane diterpenoids from a Hainan soft coral Sinularia sp. Marine Drugs 2012, 10, 2023-2032.

  26. Yang B, Zhou X, Lin X, Liu J, Peng Y, Yang X, Liu Y*. Cembrane diterpenes chemistry and biological properties. Current Organic Chemistry 2012, 16(12), 1512-1539.

  27. Chen J, Lan X, Liu Y*, Jia A. In vitro effects of natural diketopiperazines on release of cytokines and chemokines in J774A.1 macrophages. Bioorganic Medicinal Chemistry Letter 2012, 16, 3177-3180.

  28. Lin X, Zhou X, Wang F, Liu K, Yang B, Yang X, Peng P, Liu L, Ren Z, Liu Y*. A new cytotoxic sesquiterpene quinone produced by Penicillium sp. F00120 isolated from a deep sea sediment sample. Marine Drugs 2012, 10, 106-115.

  29. Kim E, Li J, Dang H, Hong J, Lee C, Kim D, Yoon W, Kim E, Liu Y, Jung J. Cytotoxic cytochalasins from the endozoic fungus Phoma sp. of the giant jellyfish Nemopilema nomurai. Bioorganic & Medicinal Chemistry Letters 2012, 22, 3126–3129.

  30. Li W, Wang L, Zhao D, Liu Y*. Steroidal alkaloids from Veratrum nigrum L. Chemistry of Natural Compounds 2012, 48(5), 919-920.

  31. He WH, Lin L, Xu T, Jung JH, Yin H, Yang B, Liu Y*. A new norsesterterpenoid from the sponge species Sarcotragus. Chemistry of Natural Compounds 2012, 48(2), 208-210.

  32. Peng Y, Xie E, Zheng K, Fredimoses M, Yang Y, Zhou X, Wang Y, Yang B, Lin X, Liu J, Liu Y*. Nutritional and Chemical Composition and Antiviral Activity of Cultivated Seaweed Sargassum naozhouense Tseng et Lu. Marine Drugs 2013, 11, 20-32.

  33. Huang R, Wang B, Liu Y*. Briarane-type diterpenoids from the gorgonian coral Verrucella umbraculum. Chemistry of Natural Compounds 2012, 48(3), 516-517.

  34. Yang B, Hu J, Lei H, Chen XC, Zhou XF, Liu Y*. Chemical constituents of marine sponge Callyspongia sp. from the South China Sea. Chemistry of Natural Compounds 2012, 48(2), 350-351.

  35. Liao X, Tang L, Liang Y, Jian S, Xu S, Liu Y*. New pentahydroxylated steroids from the South China Sea gorgonian Subergorgia suberosa Chemistry & Biodiversity 2012, 9, 370-375.

  36. Liu Y*. Renaissance of marine natural product drug discovery and development.  Journal of Marine Science Research & Development 2012, 2, 1000e106.

  37. Sun J, Huang H, Chai X, Yang X, Meng L, Huang C, Zhou X, Yang B, Hu J, Chen X, Lei H, Wang L, Liu Y*. Dichotellides A-E, five new iodine-containing briarane type diterpenoids from Dichotella gemmacea. Tetrahedron 2011, 67, 1245-1250.

  38. Wang L, Zhao D, Di L, Xu T, Lin X, Yang B, Zhou X, Yang X, Liu Y*. The analgesic and anti-rheumatic effects of Thladiantha dubia fruit crude polysaccharide fraction in mice and rats. Journal of Ethnopharmacology 2011, 137, 1381-1387.

  39. Zhou X, Lu Y, Lin X, Yang Y, Yang X, Liu Y. Brominated aliphatic hydrocarbons and sterols from the sponge Xestospongia testudinaria with their bioactivities Chemistry and Physics of lipids 2011, 164, 703-706.

  40. Yang X, Li Y, Li S, Shen Y, Tian J, Zhu Z, Feng L, Wu, L, Lin, S, Wang, N, Liu Y, Zhang W. Mono- and sesquiterpenoids, flavonoids, lignans, and other miscellaneous compounds of Abies georgei. Planta Medica 2011, 77(7), 742-748.

  41. Wang L, Zhao D, Di L, Cheng D, Zhou X, Yang X, Liu Y*. The anti-hyperplasia of mammary gland effect of Thladiantha dubia root ethanol extract in rats reduced by estrogen and progestogen. Journal of Ethnopharmacology 2011, 134, 136-140.

  42. Yang X, Dong G, Zhou X, Chai X, Li Y, Yang B, Zhang W, Liu Y*. Isolation and structural characterisation of five new and 14 known metabolites from the commercial starfish Archaster typicus Food Chemistry 2011, 124, 1634-1638.

  43. Liu Y*, Yan H, Wen K, Zhang J, Xu T, Wang L, Zhou X, Yang X. Identification of epidioxysterol from South China Sea urchin Tripneustes gratilla Linnaeus and its cytotoxic activity. Journal of Food Biochemistry 2011, 35, 932-938.

  44. Hu J, Yang B, Lin X, Zhou X, Yang X, Long L, Liu Y*. Chemical and Biological Studies of Soft Corals Nephtheidae Family. Chemistry & Biodiversity 2011, 8, 1011-1032.

  45. Dong G, Yang X, Zhou X. Liu Y*. Chemical constituents and bioactivities of starfish. Chemistry & Biodiversity 2011, 8(5), 740-791.

  46. Huang R, Zhou X, Peng Y, Yang X, Xu T, Liu Y*. Nucleosides from the marine sponge Callyspongia sp. Chemistry of Natural Compounds 2011, 46, 1010-1011.

  47. Liu Y*, Jung J, Xu T, Long LJ, Lin XP, Yin H., Yang B, Zhou XF, Yang XW. New cyclitol derivative from a sponge Sarcotragus species. Natural Products Research 2011, 25(6), 648-652.

  48. Chai X, Sun J, Tang L, Yang X, Li Y, Huang H, Zhou X, Yang B, Liu Y*. A novel cyclopentene derivative and a polyhydroxylated steroid from a South China Sea gorgonian Menella sp. Cheimcal & Pharmaceutical Bulletin 2010, 58(10), 1391-1394.

  49. Liu J, Wang L, Zhao D, Cheng D, Xu T, Zhou X, Yang X, Liu Y*. A new lignan from Saururus chinensis. Chemistry of Natural Compounds 2010, 46(4), 631-632.

  50. Zhou X, Xu T, Yang X, Xu S, Liu Y*. Chemical and biological aspects of marine sponge of the genus Xestospongia. Chemistry & Biodiversity 2010, 7, 2201-2227.

  51. Wang L, Zhou X, Xu T, Yang X, Liu Y*. Lignans from Saururus chinensis. Chemistry of Natural Compounds 2010, 46(3), 451-452.

  52. Peng Y, Zheng J, Huang R, Wang Y, Xu T, Zhou X, Liu Q, Zeng F, Ju H, Yang X, Liu Y*. Polyhydroxysteroids and saponins from the China Sea starfish Asterina sp. and their biological activities. Chemical & Pharmaceutical Bulletin 2010, 58(6), 856-858.

  53. Zhou X, Liu Y, Tang L, Zhang P, Wu J. Chemical constituents from the roots of Actinidia chinensis. Chemistry of Natural Compounds 2010, 46(2), 308-309.

  54. Huang L, Wen K, Gao X, Liu Y*. Hypolipidemic effect of fucoidan from Laminaria japonica in hyperlipidemic rats. Pharmaceutical Biology 2010, 48(4), 422-426.

  55. Huang R, Ma W, Dong J, Zhou X, Xu T, Lee K, Yang X, Xu S, Liu Y*. A new 1,4-diazepine from South China Sea marine sponge Callyspongia species. Molecules 2010, 15, 871-877.

  56. Yang X, Li S, Wu L, Li Y, Feng L, Shen Y, Tian J, Tang J, Wang N, Liu Y, Zhang W. Abiesatrines A-J: anti-inflammatory and anti-tumor triterpenoids from Abies georgei Orr. Organic & Biomolecular Chemistry 2010, 8, 2609-2616.

  57. Ren S, Ma W, Xu T, Lin X, Yin H, Yang B, Zhou X, Yang X, Long L, Lee K, Gao Q, Liu Y*. Two novel alkaloids from the South China Sea marine sponge Dysidea sp. Journal of Antibiotics 2010, 63, 699-701.

  58. Huang R, Zhou X, Xu T, Yang X, Liu Y*. Diketopiperazines from marine organisms. Chemistry & Biodiversity 2010, 7, 2809-2829.

  59. Yang X, Li S, Li Y, Xia J, Wu L, Shen Y, Tian J, Wang N, Liu Y, Zhang W. Abiespiroside A, an Unprecedented Sesquiterpenoid Spirolactone with a 6/6/5 Ring System from Abies delavayi. European Journal of Organic Chemistry 2010, 34, 6531-6534.  

  60. Xu Y, Liu Y, Xu T, Xie S, Si Y, Liu Y, Zhou H, Liu T, Xu D. A new furostanol glycoside from Tribulus terrestris. Molecules 2010, 15, 613-618.

  61. Xu Y, Bai L, Liu Y, Xu T, Liu Y, Xie S, Si Y, Zhou H, Liu T, Xu D. A new triterpenoid saponin from Pulsatilla cernua. Molecules 2010, 15, 1891-1897.

  62. Lei H, Zhou X, Yang Y, Xu T, Yang X, Sun J, Yang Y, Hu J, Lin X, Long L, Liu Y*