生物医用纳米材料，硒肽的自组装与生物效应，超分子化学

0805J1-纳米科学与技术
070305-高分子化学与物理
083100-生物医学工程

超分子自组装
生物医用纳米材料
单原子催化材料

2013-10--2016-09   东京大学   博士
2010-09--2013-07   清华大学   硕士
2006-08--2010-07   清华大学   学士

   

2018-01~现在, 国家纳米科学中心, 副研究员
2016-11~2017-12,东京大学, 博士后

   

[1] 戎宏盼, 刘山歌, 张加涛, 易宇. 空心氮掺杂碳球负载单原子钆造影剂的制备方法及应用. CN: CN113694219A, 2021-11-26.
[2] 王浩, 易宇, 魏子钰. 一种硒肽及其制备方法和应用. CN: CN112472815A, 2021-03-12.
[3] 许华平, 曾令武, 曹玮, 易宇. 含硒化合物及其制备方法、药物组合物. CN: CN103113277A, 2013-05-22.

[1] Liu, Shange, Jiang, Yuxing, Liu, Pengcheng, Yi, Yu, Hou, Dayong, Li, You, Liang, Xiao, Wang, Yifan, Li, Zhi, He, Jia, Rong, Hongpan, Wang, Dingsheng, Zhang, Jiatao. Single-Atom Gadolinium Nano-Contrast Agents with High Stability for Tumor T1 Magnetic Resonance Imaging. ACS NANO[J]. 2023, 17(9): 8053-8063, http://dx.doi.org/10.1021/acsnano.2c09664.
[2] Yang, PeiPei, Ye, XinWei, Liu, MeiQin, Yang, JinXuan, Feng, XiaoLi, Li, YiJing, Zhang, Kuo, Liang, HongWen, Yi, Yu, Wang, Lei, Liu, YiXuan, Yang, XingLou, Shi, ZhengLi, Feng, LiQiang, Chen, Ling, Xue, Yintong, PanHammarstrom, Qiang, Wang, Hao, Zhao, Yuliang. Entangling of Peptide Nanofibers Reduces the Invasiveness of SARS-CoV-2. ADVANCED HEALTHCARE MATERIALS. 2023, http://dx.doi.org/10.1002/adhm.202300673.
[3] Jiang, Yuxing, Rong, Hongtao, Wang, Yifan, Liu, Shange, Xu, Peng, Luo, Zhen, Guo, Lamei, Zhu, Tao, Rong, Hongpan, Wang, Dingsheng, Zhang, Jiatao, Yi, Yu, Wang, Hao. Single-atom cobalt nanozymes promote spinal cord injury recovery by anti-oxidation and neuroprotection. NANO RESEARCH. 2023, http://dx.doi.org/10.1007/s12274-023-5588-z.
[4] Wei, Ziyu, Yi, Yu, Luo, Zhen, Gong, Xiaoyun, Jiang, Yuxing, Hou, Dayong, Zhang, Li, Liu, Zimo, Wang, Mandi, Wang, Jie, Guo, Ruochen, Yang, Jinjun, Wang, Lei, Wang, Hao, Zhao, Yuliang. Selenopeptide Nanomedicine Activates Natural Killer Cells for Enhanced Tumor Chemoimmunotherapy. ADVANCED MATERIALS[J]. 2022, 34(17): 2108167-, [5] Liang, HongWen, Jia, Tian, Yong, Xue, Yu, JingKun, Yi, Yu, Lu, Siyu, Wang, Lei, Wang, Hao. Photoinduced Single-Crystal to Single-Crystal Transformation via Conformational Change with Turn-On Fluorescence. CRYSTAL GROWTH & DESIGN[J]. 2022, 22(4): 2082-2086, http://dx.doi.org/10.1021/acs.cgd.2c00179.
[6] Fan, Yu, Liu, Shange, Yi, Yu, Rong, Hongpan, Zhang, Jiatao. Catalytic Nanomaterials toward Atomic Levels for Biomedical Applications: From Metal Clusters to Single-Atom Catalysts. ACS NANO[J]. 2021, 15(2): 2005-2037, https://www.webofscience.com/wos/woscc/full-record/WOS:000623061800007.
[7] Hua Wang, Han Wu, Yu Yi, Ke-Fei Xue, Hao Wang, Yuliang Zhao, Xi Zhang. Self-Motivated Supramolecular Combination Chemotherapy for Overcoming Drug Resistance Based on Acid-Activated Competition of Host-Guest Interactions. CCSCHEMISTRY[J]. 2021, 3: 1413-1425, [8] Zhen Luo, Yujuan Gao, Zhongyu Duan, Yu Yi, Hao Wang. Mitochondria-Targeted Self-Assembly of Peptide-Based Nanomaterials. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY[J]. 2021, 9: 782234-, [9] Kim, Beob Soo, Naito, Mitsuru, Chaya, Hiroyuki, Hori, Mao, Hayashi, Kotaro, Min, Hyun Su, Yi, Yu, Kim, Hyun Jin, Nagata, Tetsuya, Anraku, Yasutaka, Kishimura, Akihiro, Kataoka, Kazunori, Miyata, Kanjiro. Noncovalent Stabilization of Vesicular Polyion Complexes with Chemically Modified/Single-Stranded Oligonucleotides and PEG-b-guanidinylated Polypeptides for Intracavity Encapsulation of Effector Enzymes Aimed at Cooperative Gene Knockdown. BIOMACROMOLECULES[J]. 2020, 21(10): 4365-4376, https://www.webofscience.com/wos/woscc/full-record/WOS:000580890000039.
[10] Hua Wang, Ya-Qiong Yan, Yu Yi, Zi-Yu Wei, Hao Chen, Jiang-Fei Xu, Hao Wang, Yuliang Zhao, Xi Zhang. Supramolecular Peptide Therapeutics: Host–Guest Interaction-Assisted Systemic Delivery of Anticancer Peptides. CCS Chemistry[J]. 2020, 2: 739-748, [11] Yang, PeiPei, Zhang, Kuo, He, PingPing, Fan, Yu, Gao, Xuejiao J, Gao, Xingfa, Chen, ZiMing, Hou, DaYong, Li, Yuan, Yi, Yu, Cheng, DongBing, Zhang, JingPing, Shi, Linqi, Zhang, XianZheng, Wang, Lei, Wang, Hao. A biomimetic platelet based on assembling peptides initiates artificial coagulation. SCIENCE ADVANCES[J]. 2020, 6(22): https://www.webofscience.com/wos/woscc/full-record/WOS:000537238200014.
[12] Yi, Yu, Kim, Hyun Jin, Zheng, Meng, Mi, Peng, Naito, Mitsuru, Kim, Beob Soo, Min, Hyun Su, Hayashi, Kotaro, Perche, Federico, Toh, Kazuko, Liu, Xueying, Mochida, Yuki, Kinoh, Hiroaki, Cabral, Horacio, Miyata, Kanjiro, Kataoka, Kazunori. Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells. JOURNAL OF CONTROLLED RELEASE[J]. 2019, 295: 268-277, http://dx.doi.org/10.1016/j.jconrel.2019.01.006.
[13] Kim, Beob Soo, Kim, Hyun Jin, Osawa, Shigehito, Hayashi, Kotaro, Toh, Kazuko, Naito, Mitsuru, Min, Hyun Su, Yi, Yu, Kwon, Ick Chan, Kataoka, Kazunori, Miyata, Kanjiro. Dually Stabilized Triblock Copolymer Micelles with Hydrophilic Shell and Hydrophobic Interlayer for Systemic Antisense Oligonucleotide Delivery to Solid Tumor. ACS BIOMATERIALS SCIENCE & ENGINEERING[J]. 2019, 5(11): 5770-5780, [14] Kim, Hyun Jin, Yi, Yu, Kim, Ahram, Miyata, Kanjiro. Small Delivery Vehicles of siRNA for Enhanced Cancer Targeting. BIOMACROMOLECULESnull. 2018, 19(7): 2377-2390, https://www.webofscience.com/wos/woscc/full-record/WOS:000438470800003.
[15] Yi, Yu, Lin, Gan, Chen, Shaoyi, Liu, Jing, Zhang, Huaping, Mi, Peng. Polyester micelles for drug delivery and cancer theranostics: Current achievements, progresses and future perspectives. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONSnull. 2018, 83: 218-232, http://dx.doi.org/10.1016/j.msec.2017.10.004.
[16] Zheng, Meng, Kim, Hyun Jin, Oosawa, Shigehito, Yi, Yu, Miyata, Kanjiro, Kataoka, Kazunori. Unimer polyion complex self-assembled nanomicelle for systemic delivery of siRNA into solid tumor. JOURNAL OF CONTROLLED RELEASEnull. 2017, 259: E91-E92, http://dx.doi.org/10.1016/j.jconrel.2017.03.197.
[17] Perche, F, Yi, Y, Hespel, L, Mi, P, Dirisala, A, Cabral, H, Miyata, K, Kataoka, K. Hydroxychloroquine-conjugated gold nanoparticles for improved siRNA activity. BIOMATERIALS[J]. 2016, 90: 62-71, http://dx.doi.org/10.1016/j.biomaterials.2016.02.027.
[18] Ishii, Takehiko, Miyata, Kanjiro, Anraku, Yasutaka, Naito, Mitsuru, Yi, Yu, Jinbo, Takao, Takae, Seiji, Fukusato, Yu, Hori, Mao, Osada, Kensuke, Kataoka, Kazunori. Enhanced target recognition of nanoparticles by cocktail PEGylation with chains of varying lengths. CHEMICAL COMMUNICATIONS[J]. 2016, 52(7): 1517-1519, https://www.webofscience.com/wos/woscc/full-record/WOS:000368352900049.
[19] Yi, Yu, Kim, Hyun Jin, Mi, Peng, Zheng, Meng, Takemoto, Hiroyasu, Toh, Kazuko, Kim, Beob Soo, Hayashi, Kotaro, Naito, Mitsuru, Matsumoto, Yu, Miyata, Kanjiro, Kataoka, Kazunori. Targeted systemic delivery of siRNA to cervical cancer model using cyclic RGD-installed unimer polyion complex-assembled gold nanoparticles. JOURNAL OF CONTROLLED RELEASE[J]. 2016, 244: 247-256, http://dx.doi.org/10.1016/j.jconrel.2016.08.041.
[20] Nishida, Haruka, Matsumoto, Yoko, Kawana, Kei, Christie, R James, Naito, Mitsuru, Kim, Beob Soo, Toh, Kazuko, Min, Hyun Su, Yi, Yu, Matsumoto, Yu, Kim, Hyun Jin, Miyata, Kanjiro, Taguchi, Ayumi, Tomio, Kensuke, Yamashita, Aki, Inoue, Tomoko, Nakamura, Hiroe, Fujimoto, Asaha, Sato, Masakazu, Yoshida, Mitsuyo, Adachi, Katsuyuki, Arimoto, Takahide, WadaHiraike, Osamu, Oda, Katsutoshi, Nagamatsu, Takeshi, Nishiyama, Nobuhiro, Kataoka, Kazunori, Osuga, Yutaka, Fujii, Tomoyuki. Systemic delivery of siRNA by actively targeted polyion complex micelles for silencing the E6 and E7 human papillomavirus oncogenes. JOURNAL OF CONTROLLED RELEASE[J]. 2016, 231: 29-37, http://dx.doi.org/10.1016/j.jconrel.2016.03.016.
[21] Li, Tianyu, Li, Feng, Xiang, Wentian, Yi, Yu, Chen, Yuyan, Cheng, Liang, Liu, Zhuang, Xu, Huaping. Selenium-Containing Amphiphiles Reduced and Stabilized Gold Nanoparticles: Kill Cancer Cells via Reactive Oxygen Species. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 8(34): 22106-22112, https://www.webofscience.com/wos/woscc/full-record/WOS:000382514100031.
[22] Wang, Lu, Cao, Wei, Yi, Yu, Xu, Huaping. Dual Redox Responsive Coassemblies of Diselenide-Containing Block Copolymers and Polymer Lipids. LANGMUIR[J]. 2014, 30(19): 5628-5636, https://www.webofscience.com/wos/woscc/full-record/WOS:000336414500035.
[23] Kim, Hyun Jin, Takemoto, Hiroyasu, Yi, Yu, Zheng, Meng, Maeda, Yoshinori, Chaya, Hiroyuki, Hayashi, Kotaro, Mi, Peng, Pittella, Frederico, Christie, R James, Toh, Kazuko, Matsumoto, Yu, Nishiyama, Nobuhiro, Miyata, Kanjiro, Kataoka, Kazunori. Precise Engineering of siRNA Delivery Vehicles to Tumors Using Polyion Complexes and Gold Nanoparticles. ACS NANO[J]. 2014, 8(9): 8979-8991, https://www.webofscience.com/wos/woscc/full-record/WOS:000342184400026.
[24] Zeng, Lingwu, Li, Yang, Li, Tianyu, Cao, Wei, Yi, Yu, Geng, Weijia, Sun, Zhiwei, Xu, Huaping. Selenium-Platinum Coordination Compounds as Novel Anticancer Drugs: Selectively Killing Cancer Cells via a Reactive Oxygen Species (ROS)-Mediated Apoptosis Route. CHEMISTRY-AN ASIAN JOURNAL[J]. 2014, 9(8): 2295-2302, https://www.webofscience.com/wos/woscc/full-record/WOS:000342675900043.
[25] Li Tianyu, Yi Yu, Xu Huaping. Selenium-containing Coordinating Assemblies with Selective Anti-cancer Activity: the Control of Reactive Oxygen Species. ACTA CHIMICA SINICA[J]. 2014, 72(10): 1079-1084, https://www.webofscience.com/wos/woscc/full-record/WOS:000345818800004.
[26] Ding, Yan, Yi, Yu, Xu, Huaping, Wang, Zhiqiang, Zhang, Xi. Redox-responsive thermal sensitivity based on a selenium-containing small molecule. CHEMICAL COMMUNICATIONS[J]. 2014, 50(20): 2585-2588, https://www.webofscience.com/wos/woscc/full-record/WOS:000331175100008.
[27] Li Tianyu, Yi Yu, Xu Huaping. Selenium-containing Coordinating Assemblies with Selective Anti-cancer Activity: the Control of Reactive Oxygen Species. ACTA CHIMICA SINICA[J]. 2014, 72(10): 1079-1084, https://www.webofscience.com/wos/woscc/full-record/WOS:000345818800004.
[28] Yi, Yu, Xu, Huaping, Wang, Lu, Cao, Wei, Zhang, Xi. A New Dynamic Covalent Bond of SeN: Towards Controlled Self-Assembly and Disassembly. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2013, 19(29): 9506-9510, https://www.webofscience.com/wos/woscc/full-record/WOS:000321431600020.
[29] Yi, Yu, Fa, Shixin, Cao, Wei, Zeng, Lingwu, Wang, Meixiang, Xu, Huaping, Zhang, Xi. Fabrication of well-defined crystalline azacalixarene nanosheets assisted by Se center dot center dot center dot N non-covalent interactions. CHEMICAL COMMUNICATIONS[J]. 2012, 48(60): 7495-7497, https://www.webofscience.com/wos/woscc/full-record/WOS:000305883400021.
[30] Cao, Wei, Li, Yang, Yi, Yu, Ji, Shaobo, Zeng, Lingwu, Sun, Zhiwei, Xu, Huaping. Coordination-responsive selenium-containing polymer micelles for controlled drug release. CHEMICAL SCIENCE[J]. 2012, 3(12): 3403-3408, https://www.webofscience.com/wos/woscc/full-record/WOS:000311920500009.
[31] Liu, Zhihua, Yi, Yu, Gauczinski, Jan, Xu, Huaping, Schoenhoff, Monika, Zhang, Xi. Surface Molecular Imprinted Layer-by-Layer Film Attached to a Porous Membrane for Selective Filtration. LANGMUIR[J]. 2011, 27(19): 11806-11812, https://www.webofscience.com/wos/woscc/full-record/WOS:000295187300013.
[32] Liu, Zhihua, Yi, Yu, Xu, Huaping, Zhang, Xi, Ngo, Thien Huynh, Smet, Mario. Cation-Selective Microcontact Printing Based on Surface-Molecular-Imprinted Layer-by-Layer Films. ADVANCED MATERIALS[J]. 2010, 22(24): 2689-+, http://www.corc.org.cn/handle/1471x/2414738.

   

（ 1 ） 新型含硒多肽聚合物的精准合成及其抗癌应用研究, 主持, 国家级, 2019-01--2021-12
（ 2 ） 自组装纳米材料安全性评价, 主持, 国家级, 2019-08--2022-07
（ 3 ） 超分子多肽递送体系在肿瘤治疗与新冠疫苗中的研究, 主持, 国家级, 2022-01--2025-12