基本信息
高莹  女  博导  中国科学院上海营养与健康研究院
电子邮件: yinggao@sibs.ac.cn
通信地址: 岳阳路320 号
邮政编码: 200031
部门/实验室:营养科学研究所

研究领域

以人群研究(流行病学)为基础,结合代谢组学、表观遗传学组学和基因组学等研究方法,系统地探索营养与表观遗传和遗传因素共同作用,对健康结局的影响, 并探讨这些因素对疾病的预测作用。通过临床试验和人群营养干预研究,探讨膳食营养因素对生长发育促进、慢性病预防和癌症病人生活质量的影响及其潜在机理,为个体化营养​提供依据。

招生信息

拟招收对分子流行病、分子生物学、营养和生物信息等领域感兴趣的学生和研究人员。

招生专业
071003-生理学
100104-病理学与病理生理学
招生方向
分子流行病学
营养分子流行病学

教育背景

2001-08--2006-12   Cornell University   PhD
1998-09--2001-06   北京大学   医学硕士
1993-09--1998-06   北京医科大学   医学学士
学历
   
学位
   

工作经历

   
工作简历
2012-08~现在, 中国科学院上海生命科学研究院, 研究员
2007-01~2012-07,美国NCI, 博士后
社会兼职
2019-04-01-今,中国营养学会营养流行病学分会委员会委员,
2019-02-19-今,Journal of Nutritional Biochemistry,
2013-10-10-今,中国抗癌协会肿瘤病因学分委会委员,

教授课程

营养学
表观遗传和癌症流行病学

专利与奖励

   
奖励信息
   
专利成果
( 1 ) 超长链饱和脂肪酸或其检测试剂在代谢综合征患病风险预测中的应用, 发明, 2017, 第 1 作者, 专利号: 201710322708.2
( 2 ) 血脂紊乱相关的代谢性疾病易感性的相关位点及检测方法和试剂盒, 发明, 2017, 第 1 作者, 专利号: 201710433873.5

出版信息

 

1.      Shuchun Lin, Yun Liu, Lynn R Goldin, Chen Lyu,  Xiangyin Kong, Yan Zhang,  Neil E Caporaso  Song Xiang , Ying Gao*. Sex related DNA methylation differences in B cell chronic lymphocytic leukemia. Biology of Sex Differences, 2019, 10:2

 

2.      Kangning Chen, Qianyu Zhao, Xiaofan Li, Jing Zhao, Peiqin Li, Shuchun Lin, Hongwei Wang, Jiajie Zang, Ying Xiao, Wanghong Xu, Fuxue Chen, Ying Gao*. Dietary fiber intake and endometrial cancer risk: A systematic review and meta-analysis. Nutrients, 2018, 10(7). pii: E945. doi: 10.3390/nu10070945

 

3.      Jing Zhao, Xiaofan Li, Xiang Li, Qianqian Chu, Yunhua Zhou, Zi Li, Hong Zhang, Thomas J Brenna, Yiqing Song, Ying Gao*. Associations of plasma very long chain saturated fatty acids and metabolic syndrome in Chinese adults. British Journal of Nutrition, 2018 ; 120(8):855-862

 

4.      Jie Liu, ShengQuan Mi, Li Du, Xiang Li , Jing Zhao, Hong Zhang, WenHua Zhao* and Ying Gao* The associations between plasma phytoestrogens concentration and metabolic syndrome risks in Chinese population, Plos One 2018  doi: 10.1371/journal.pone.0194639.

 

5.      Peiqin Li, Jing Zhao, Kumar Kothapalli,  Xiang Li, Hui Li, Yuxuan Han, Shengquan Mi,  Wenhua Zhao,  Qizhai Li, Hong Zhang,  Yiqing Song, J. Thomas Brenna, Ying Gao*.  A regulatory insertion-deletion polymorphism in the FADS gene cluster influences PUFA and lipid profiles among Chinese adults: a population-based study. American Journal of Clinical Nutrition 2018 ; 107(6):867-875

 

6.      Xiang Li, Hui Li, Jing Zhao, Qi Dai, Chaoran Huang, Langping Jin, Fan Yang, Fuxue Chen, Ouchen Wang and Ying Gao*. Plasma ω3 and ω6 fatty acids in thyroid diseases. Oncology Letters. 2018; 16(4):5433-5440

 

7.      Xiao-fan Li, Jing Zhao, Peiqin Li, Ying Gao* Dairy products intake and endometrial cancer risk: a meta-analysis of observational studies. Nutrients 201710(1). pii: E25. doi: 10.3390/nu10010025.

 

8.      Hui Li, Xiang Li, Jie Liu, Langping Jin, Fang Yang, Junbo Wang, Ouchen Wang, Ying Gao*. Correlation between serum lead and thyroid diseases: papillary thyroid carcinoma, nodular goiter, and thyroid adenoma.  International Journal of Environmental Health Research, 2017, 11:1-10  doi: 10.1080/09603123.2017.1373273

 

9.      李慧,郭倩颖,柳鹏,张岩春,戴智勇,高莹,王军波。不同时期母乳中脂肪酸水平的变化。中国食物与营养 2017, 23 (5) :54-58

 

10.  Yanhui Hao; Jing Zhao; Kan Wang; Nannan Feng; Pin Sun; Renjie Chen; Bin Han;  Zhipeng Bai;  Yiliang Zhu; Ying Gao*; Zhao-lin Xia*. The Association between Particulate Matter Air Pollution and Respiratory Health in Elderly with Type 2 Diabetes Mellitus. Journal of Occupational and Environmental Medicine. 2017 ; 59(9):830-834

 

11.  Li Du, Yulong Wang, Hang Zhang, Hong Zhang, Ying Gao *. Folate intake and the risk of endometrial cancer: A meta-analysis. Oncotarget 2016, 7(51):85176-85184

 

12.  Jing Zhao, Lvy Chen, Jian Gao, Li Du, Boer Shan, Hong Zhang, Huaying Wang, and Ying Gao*. Dietary fat intake and endometrial cancer risk: a dose-response meta-analysis. Medicine, 2016, 95(27):e4121 DOI: 10.1097/MD.0000000000004121

 

13.  Jie Liu, Feixiang Yuan, Jian Gao, Boer Shan, Yulan Ren, Huaying Wang, Ying Gao*. Oral isoflavone supplementation on endometrial thickness: a meta-analysis of randomized placebo-controlled trials. Oncotarget 2016, 7(14):17369-79

 

14.  Jun Han,  Yi Jiang, Xiao Liu,  Qingyang Meng,  Qiulei Xi,  Qiulin Zhuang,  Yusong Han, Ying Gao,  Qiurong Ding,  and Guohao Wu. . Dietary Fat Intake and Risk of Gastric Cancer: A Meta-Analysis of Observational Studies. Plos One, 2015: 10(9):e0138580

 

15.  Sigurdur Y. Kristinsson#, Ying Gao#, Magnus Björkholm, Sigrun Helga Lund, Jan Sjöberg, Neil Caporaso, Lynn R. Goldin, Ola Landgren Hodgkin lymphoma risk following infectious and chronic inflammatory diseases: a large population-based case-control study from Sweden. International Journal of  Hematology 2015;101(6):563-8  (# equal contribution)

 

16.  Jing Zhao, Jing Wang, Jinfeng Du, Hongli Xu, Wei Zhang, Quan-Xing Ni, Herbert Yu, Harvey A. Risch, Yu-Tang Gao, Ying Gao*. Urinary prostaglandin E2 metabolite and pancreatic cancer risk: case-control study in urban Shanghai. Plos One, 2015:10(2):e0118004

                                                                                                                                                                                                                                                                             

17.  Wen-Qing Li, Nan Hu, Paula L. Hyland, Ying Gao, Zhao-Ming Wang, Kai Yu, Hua Su, Chao-Yu Wang, Le-Min Wang, Stephen J. Chanock, Laurie Burdett, Ti Ding, You-Lin Qiao, Jin-Hu Fan, Yuan Wang, Yi Xu, Jian-Xin Shi, Fangyi Gu, William Wheeler, Xiao-Qin Xiong, Carol Giffen, Margaret A. Tucker, Sanford M. Dawsey, Neal D. Freedman, Christian C. Abnet, Alisa M. Goldstein, Philip R. Taylor. Genetic variants in DNA repair pathway genes and risk of esophageal squamous cell carcinoma and gastric adenocarcinoma in a Chinese population. Carcinogenesis, 2013; 34:1536-1542

 

18.  Ying Gao*, Keith Killian, Hong Zhang, Kai Yu, Qi-Zhai Li, Stephanie Weinstein, Jarmo Virtamo, Margaret Tucker, Philip Taylor, Demetrius Albanes, Paul Meltzer, Neil Caporas. Leukocyte DNA methylation and colorectal cancer among male smokers.  World Journal of Gastrointestinal Oncology. 2012;4:193-201

 

19.  David E. Capo-Ramos, Ying Gao, Jay H. Lubin, David P. Check, Lynn R. Goldin, Angela C. Pesatori, Dario Consonni, Pier Alberto Bertazzi, Andrew J. Saxon, Andrew W. Bergen, Neil E. Caporaso, Maria Teresa Landi. Mood disorders and risk of lung cancer in the EAGLE Case-control study and in the U.S. Veterans Affairs inpatient cohort. Plos One, 2012; 7:e42945

 

20.  Qizhai Li, Dongdong Pan, Weihua Yue, Ying Gao, Kai Yu. Evaluating rare variants under two- stage design. Journal of Human Genetics, 2012; 57:352-357

 

21.  Yoon Jung Park, Herry Herman, Ying Gao, Anders M. Lindroth, Benjamin Y. Hu, Patrick J. Murphy, James R. Putnam, Paul D. Soloway. Sequences sufficient for programming imprinted germ line DNA methylation defined. Plos One, 2012;7:e33024

 

22.  Ying Gao*, Hormuzd Katki , Barry Graubard, Michael Pollak , Michael Martin , Yuzhen Tao , Robert E. Schoen , Timothy Church , Richard B. Hayes , Mark H. Greene , Sonja I. Berndt. Serum IGF1, IGF2, and IGFBP3 and risk of advanced colorectal adenoma. International Journal of  Cancer, 2012; 131:E105-113

 

23.  Gao Y*, Baccarelli A, Shu XO, Ji BT, Yu K, Tarantini L, Yang G, Li HL, Hou L, Rothman N, Zheng W, Gao YT, Chow WH. Blood leukocyte Alu and LINE-1 methylation and gastric cancer risk in the Shanghai Women’s Health Study. British Journal of  Cancer 2012; 106:585-591

 

24.  Freddy Sitas, Sam Egger, Margaret I. Urban, Philip R. Taylor, Christian C. Abnet, Paolo Boffetta, Dianne L. O’Connell, David C. Whiteman, Paul Brennan, Reza Malekzadeh, Michael Pawlita, Sanford M. Dawsey, and Tim Waterboer, on behalf of the InterSCOPE Collaboration. Penelope M. Webb, Adèle C. Green, Nicholas K. Hayward, David Zaridze, Ivana Holcatova, Dana Mates, Neonila Szeszenia-Dabrowska, Gilles Ferro, Vladimir Janout, Maria Paula Curado, Ana Maria Menezes, Sergio Koifman, Farhad Islami, Dariush Nasrollahzadeh, Nan Hu, Alisa M. Goldstein, Ying Gao, Ti Ding, and Farin Kamangar. InterSCOPE Study:  Associations Between Esophageal Squamous Cell Carcinoma and Human Papillomavirus Serological Markers. Journal of the National Cancer Institute 2012; 104: 147-158

 

25.  Ying Gao*, Nan Hu, Xiao You Han, Ti Ding, Carol Giffen, Alisa M Goldstein, Philip R Taylor. Risk factors for esophageal and gastric cancers in Shanxi Province, China: a case-control study. Cancer Epidemiology 2011; 35: e91-e99

 

26.  Ying Gao*, Richard B. Hayes, Wen-Yi Huang, Neil E. Caporaso, Laurie Burdette, Meredith Yeager, Stephen J. Chanock, Sonja I. Berndt DNA repair gene polymorphisms and tobacco smoking in the risk for colorectal adenomas. Carcinogenesis 2011; 32:882-887

 

27.  Ying Gao*,Nan Hu, XiaoYou Han, Carol Giffen,Ti Ding, Alisa Goldstein, and Philip Taylor. Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China. BMC Cancer 2009; 9:269

 

28.  Ying Gao*, Nan Hu , Xiaoyou Han, Carol Giffen, Ti Ding, Alisa M. Goldstein, Philip R.Taylor PR. Jasmine tea consumption and upper gastrointestinal cancer in China. Cancer Causes Control 2009; 20:1997-2007

 

29.  Xueying Liang, Ying Gao, Tram K Lam, Qizhai Li, Cathy Falk, Xiaohong R Yang, Alisa M Goldstein, and Lynn R Goldin. Identifying rheumatoid arthritis susceptibility genes using high-dimensional methods. BMC Proceedings, 2009; 3: S79

 

30.  Ying Gao, Alisa M. Goldstein, Dario Consonni, Angela C. Pesatori, Sholom Wacholder, Margaret A. Tucker, Neil E. Caporaso, Lynn Goldin, Maria Teresa Landi. Family history of cancer and nonmalignant lung diseases as risk factors for lung cancer. International Journal of  Cancer 2009; 125:146-152

 

31.  Ying Gao*, Sigurdur Y Kristinsson, Lynn R Goldin, Magnus  Björkholm, Neil E Caporaso, and Ola Landgren . Increased risk for non-Hodgkin lymphoma in individuals with celiac disease and a potential familial   association. Gastroenterology 2009; 136: 91-98

 

32.  Ying Gao*, Martha S. Linet, Gloria Gridley, Lene Mellemkjaer, Kari Hemminki, Lynn R. Goldin, Ola Landgren. Shared susceptibility for celiac disease and inflammatory bowel disease? Scandinavian journal of Gastroenterology 2008; 43:1279-1280

 

33.  高莹,肖颖. 山楂及山楂黄酮提取物调节大鼠血脂的效果研究 中国食品卫生杂志2002;14(3): 14-16

 

34.  Ying Gao, Keji Li, Shiying Tang, Ying Xiao. Study on animal models for hyperlipidemia. Wei Sheng  Yan Jiu 2002; 31: 97-99

 

35.  李可基,肖颖,周兰兰,陈志民,刘晓鹏,唐世英,高莹,钮文异。 卫生系统女性骨质疏松病和钙营养知识的调查 . 中国健康教育 2000; 16: 333-337

发表论文
(1) Sex related DNA methylation differences in B cell chronic lymphocytic leukemia, Biology of Sex Differences, 2019, 通讯作者
(2) Plasma ω‑3 and ω‑6 fatty acids in thyroid diseases, Oncology Letters, 2018, 通讯作者
(3) A regulatory insertion-deletion polymorphism in the FADS gene cluster influences PUFA and lipid profiles among Chinese adults: a population-based study, American Journal of Clinical Nutrition, 2018, 通讯作者
(4) The associations between plasma phytoestrogens concentration and metabolic syndrome risks in Chinese population, Plos One, 2018, 通讯作者
(5) Associations of plasma very long chain saturated fatty acids and metabolic syndrome in Chinese adults, British Journal of Nutrition, 2018, 通讯作者
(6) Dietary fiber intake and endometrial cancer risk: A systematic review and meta-analysis., Nutrients, 2018, 通讯作者
(7) The Association between Particulate Matter Air Pollution and Respiratory Health in Elderly with Type 2 Diabetes Mellitus, Journal of Occupational and Environmental Medicin, 2017, 通讯作者
(8) 不同时期母乳中脂肪酸水平的变化, 中国食物与营养, 2017, 其他(合作组作者)
(9) Correlation between serum lead and thyroid diseases: papillary thyroid carcinoma, nodular goiter, and thyroid adenoma, International Journal of Environmental Health Research, 2017, 通讯作者
(10) Dairy products intake and endometrial cancer risk: a meta-analysis of observational studies, Nutrients, 2017, 通讯作者
(11) Folate intake and the risk of endometrial cancer: A meta-analysis, oncotarget, 2016, 通讯作者
(12) Oral isoflavone supplementation on endometrial thickness: a meta-analysis of randomized placebo-controlled trials, Oncotarget, 2016, 通讯作者
(13) Dietary fat intake and endometrial cancer risk: a dose-response meta-analysis, Medicine, 2016, 通讯作者
(14) Urinary prostaglandin E2 metabolite and pancreatic cancer risk: case-control study in urban Shanghai, Plos One, 2015, 通讯作者
(15) Hodgkin lymphoma risk following infectious and chronic inflammatory diseases: a large population-based case-control study from Sweden, Int J Hematol, 2015, 第 1 作者
(16) Dietary Fat Intake and Risk of Gastric Cancer: A Meta-Analysis of Observational Studies, Plos One, 2015, 第 4 作者
(17) Genetic variants in DNA repair pathway genes and risk of esophageal squamous cell carcinoma and gastric adenocarcinoma in a Chinese population, Carcinogenesis, 2013, 第 4 作者
(18) InterSCOPE Study: Associations Between Esophageal Squamous Cell Carcinoma and Human Papillomavirus Serological Markers., J Natl Cancer Inst,, 2012, 第 4 作者
(19) Blood leukocyte Alu and LINE-1 methylation and gastric cancer risk in the Shanghai Women’s Health Study, Br J Cancer, 2012, 通讯作者
(20) Serum IGF1, IGF2, and IGFBP3 and risk of advanced colorectal adenoma, Int J Cancer, 2012, 通讯作者
(21) Sequences sufficient for programming imprinted germ line DNA methylation defined, Plos One, 2012, 第 3 作者
(22) Evaluating rare variants under two- stage design, J Hum Genet, 2012, 第 4 作者
(23) Mood disorders and risk of lung cancer in the EAGLE Case-control study and in the U.S. Veterans Affairs inpatient cohort, Plos One,, 2012, 第 2 作者
(24) Leukocyte DNA methylation and colorectal cancer among male smokers, World J Gastrointest Oncol., 2012, 通讯作者
(25) DNA repair gene polymorphisms and tobacco smoking in the risk for colorectal adenomas, Carcinogenesis, 2011, 通讯作者
(26) Risk factors for esophageal and gastric cancers in Shanxi Province, China: a case-control study, Cancer Epidemiol, 2011, 通讯作者
(27) Increased risk for non-Hodgkin lymphoma in individuals with celiac disease and a potential familial association, Gastroenterology, 2009, 通讯作者
(28) Family history of cancer and nonmalignant lung diseases as risk factors for lung cancer, Int J Cancer, 2009, 第 1 作者
(29) Identifying rheumatoid arthritis susceptibility genes using high-dimensional methods, BMC Proc, 2009, 第 2 作者
(30) Jasmine tea consumption and upper gastrointestinal cancer in China, Cancer Causes Control, 2009, 通讯作者
(31) Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China, BMC Cancer, 2009, 通讯作者
(32) Shared susceptibility for celiac disease and inflammatory bowel disease?, Scand J Gastroenterol, 2008, 通讯作者
发表著作
   

科研活动

   
科研项目
( 1 ) 中国科学院百人计划, 主持, 研究所(学校), 2013-08--2016-12
( 2 ) 酶法改性技术对脂质类食品关键结构(域)修饰与功能活性调控机理(新型食品加工技术对特征组分结构修饰与品质功能调控机理), 参与, 国家级, 2016-07--2020-12
参与会议
   

合作情况

   
项目协作单位
   

指导学生

已指导学生

刘洁  硕士研究生  071010-生物化学与分子生物学  

赵晶  博士研究生  071010-生物化学与分子生物学  

林树椿  硕士研究生  071010-生物化学与分子生物学  

李佩芹  硕士研究生  071010-生物化学与分子生物学  

现指导学生

赵倩玉  硕士研究生  100104-病理学与病理生理学  

胡帆  硕士研究生  100104-病理学与病理生理学  

贾克钰  博士研究生  100104-病理学与病理生理学  

张秋怡  博士研究生  100104-病理学与病理生理学  

章露婷  硕士研究生  071009-细胞生物学  

张馨奕  硕士研究生  071010-生物化学与分子生物学