Drug repurposing; Antivirals; Natural Products; Bone disease

2010-2014 PhD Chinese University of Hong Kong

2007-2010 Master China Pharmaceutical University

2003-2007 Bachelor Nanjing University of Chinese Medicine

2018-current Associate Professor Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences

2015-2018 Postdoc Fellow Center for Drug Design, University of Minnesota

2013-2015 Research Assistant Chinese University of Hong Kong 

1. Xie Q, Shen YN, Liang JH, Zhang C, Ling XW, Gu LX, Wang YL, Wang Y, Liu XP and Hu C. Design and synthesis of 1,3-diphenylpyrimidine-2,4(1H,3H)-dione derivatives as antitumor agents via elevating ROS production to induce apoptosis. New J Chem. 2022; 46(25):12278-12289.

2. Xie Q, Shen Y, Meng Y, Liang J, Xu J, Liang S, Liu X, Wang Y and Hu C. Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione derivatives as RAF-MEK-ERK pathway signaling pathway blockers: Synthesis, cytotoxic activity, mechanistic investigation and structure-activity relationships. European journal of medicinal chemistry. 2022; 240:114579.

3. Wan JF, Wang G, Qin FY, Huang DL, Wang Y, Su AL, Zhang HP, Liu Y, Zeng SY, Wei CL, Cheng YX and Liu J. Z16b, a natural compound from Ganoderma cochlear is a novel RyR2 stabilizer preventing catecholaminergic polymorphic ventricular tachycardia. Acta pharmacologica Sinica. 2022.

4. Senaweera S, Edwards TC, Kankanala J, Wang Y, Sahani RL, Xie J, Geraghty RJ and Wang Z. Discovery of N-benzyl hydroxypyridone carboxamides as a novel and potent antiviral chemotype against human cytomegalovirus (HCMV). Acta pharmaceutica Sinica B. 2022; 12(4):1671-1684.

5. Hu Z, Hu H, Hu Z, Zhong X, Guan Y, Zhao Y, Wang L, Ye L, Ming L, Riaz Rajoka MS, He Z, Wang Y and Song X. Sanguinarine, Isolated From Macleaya cordata, Exhibits Potent Antifungal Efficacy Against Candida albicans Through Inhibiting Ergosterol Synthesis. Frontiers in microbiology. 2022; 13:908461.

6. Wang Y, Soto-Acosta R, Ding R, Chen L and Geraghty RJ. Anti-HCMV activity by an irreversible p97 inhibitor LC-1310. Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents. 2021; 30(2):440-448.

7. Chen J, Cheng W, Li J, Wang Y, Chen J, Shen X, Su A, Gan D, Ke L, Liu G, Lin J, Li L, Bai X, et al. Notch-1 and Notch-3 Mediate Hypoxia-Induced Activation of Synovial Fibroblasts in Rheumatoid Arthritis. Arthritis & rheumatology. 2021; 73(10):1810-1819.

8. Wang Y, Xiao CY, Lin HQ, Hu JS, Ip TM and Chi-Cheong Wan D. Development of an enzyme-linked immunosorbent assay for Keap1-Nrf2 interaction inhibitors identification. Redox biology. 2020; 34:101573.

9. Wang Y and Chen L. Tissue distributions of antiviral drugs affect their capabilities of reducing viral loads in COVID-19 treatment. European journal of pharmacology. 2020; 889:173634.

10. Wang Y and Chen L. Lung tissue distribution of drugs as a key factor for COVID-19 treatment. British journal of pharmacology. 2020; 177(21):4995-4996.

11. Qin FY, Zhang HX, Di QQ, Wang Y, Yan YM, Chen WL and Cheng YX. Ganoderma cochlear Metabolites as Probes to Identify a COX-2 Active Site and as in Vitro and in Vivo Anti-Inflammatory Agents. Organic letters. 2020; 22(7):2574-2578.

12. Hu Y, Zhang T, Chen J, Cheng W, Chen J, Zheng Z, Lin J, Zhu G, Zhang Y, Bai X, Wang Y, Song B, Wang Q, et al. Downregulation of Hypoxia-Inducible Factor-1alpha by RNA Interference Alleviates the Development of Collagen-Induced Arthritis in Rats. Molecular therapy Nucleic acids. 2020; 19:1330-1342.

13. Cheng WX, Huang H, Chen JH, Zhang TT, Zhu GY, Zheng ZT, Lin JT, Hu YP, Zhang Y, Bai XL, Wang Y, Xu ZW, Song B, et al. Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway. Journal of orthopaedic translation. 2020; 22:92-100.

14. Yan YM, Zhang HX, Liu H, Wang Y, Wu JB, Li YP and Cheng YX. (+/-)-Lucidumone, a COX-2 Inhibitory Caged Fungal Meroterpenoid from Ganoderma lucidum. Organic letters. 2019; 21(21):8523-8527.

15. Wang Y and Geraghty RJ. FRET-based assay using a three-way junction DNA substrate to identify inhibitors of human cytomegalovirus pUL89 endonuclease activity. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2019; 127:29-37.

16. Wang Y, Tang J, Wang Z and Geraghty RJ. Metal-chelating 3-hydroxypyrimidine-2,4-diones inhibit human cytomegalovirus pUL89 endonuclease activity and virus replication. Antiviral research. 2018; 152:10-17.

17. Pan WL, Wang Y, Hao Y, Wong JH, Chan WC, Wan DC and Ng TB. Overexpression of CXCR4 synergizes with LL-37 in the metastasis of breast cancer cells. Biochimica et biophysica acta Molecular basis of disease. 2018; 1864(11):3837-3846.

18. Kankanala J, Wang Y, Geraghty RJ and Wang Z. Hydroxypyridonecarboxylic Acids as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease. ChemMedChem. 2018; 13(16):1658-1663.

19. Hou S, Xu H, Hu J, Hou J, Wang Y, Jin Z, Wan DCC and Hu C. Synthesis, beta -catenin Translocation Capability and ALP Activation Activity of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one Derivatives. Medicinal chemistry. 2018; 14(1):67-73.

20. Zhou W, Wang Y, Xie J and Geraghty RJ. A fluorescence-based high-throughput assay to identify inhibitors of tyrosylprotein sulfotransferase activity. Biochemical and biophysical research communications. 2017; 482(4):1207-1212.

21. Wang Y, Qi W, Zhang L, Ying Z, Sha O, Li C, Lu L, Chen X, Li Z, Niu F, Xue F, Wang D, Ng TB, et al. The novel targets of DL-3-n-butylphthalide predicted by similarity ensemble approach in combination with molecular docking study. Quantitative imaging in medicine and surgery. 2017; 7(5):532-536.

22. Wang Y, Mao L, Kankanala J, Wang Z and Geraghty RJ. Inhibition of Human Cytomegalovirus pUL89 Terminase Subunit Blocks Virus Replication and Genome Cleavage. Journal of virology. 2017; 91(3).

23. Wang Y, Lin HQ, Wang P, Hu JS, Ip TM, Yang LM, Zheng YT and Chi-Cheong Wan D. Discovery of a Novel HIV-1 Integrase/p75 Interacting Inhibitor by Docking Screening, Biochemical Assay, and in Vitro Studies. Journal of chemical information and modeling. 2017; 57(9):2336-2343.

24. Wang Y, Lin HQ, Xiao CY, Law WK, Hu JS, Ip TM and Wan DCC. Using molecular docking screening for identifying hyperoside as an inhibitor of fatty acid binding protein 4 from a natural product database. J Funct Foods. 2016; 20:159-170.

25. Wang Y, Hu JS, Lin HQ, Ip TM and Wan DC. Herbalog: A tool for target-based identification of herbal drug efficacy through molecular docking. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2016; 23(12):1469-1474.

26. Wang WY, Wong JH, Ip DT, Wan DC, Cheung RC and Ng TB. Bovine Lactoferrampin, Human Lactoferricin, and Lactoferrin 1-11 Inhibit Nuclear Translocation of HIV Integrase. Applied biochemistry and biotechnology. 2016; 179(7):1202-1212.

27. Zhou X, Wang Y, Lee WY, Or PM, Wan DC, Kwan YW and Yeung JH. Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells. Journal of natural products. 2015; 78(9):2266-2275.

28. Wang Y, Lin HQ, Law WK, Liang WC, Zhang JF, Hu JS, Ip TM, Waye MM and Wan DC. Pimozide, a novel fatty acid binding protein 4 inhibitor, promotes adipogenesis of 3T3-L1 cells by activating PPARgamma. ACS chemical neuroscience. 2015; 6(2):211-218.

29. Ng TB, Cheung RC, Wong JH, Wang Y, Ip DT, Wan DC and Xia J. Antiviral activities of whey proteins. Applied microbiology and biotechnology. 2015; 99(17):6997-7008.

30. Liang WC, Wang Y, Liang PP, Pan XQ, Fu WM, Yeung VS, Lu YF, Wan DC, Tsui SK, Tsang SY, Ma WB, Zhang JF and Waye MM. MiR-25 suppresses 3T3-L1 adipogenesis by directly targeting KLF4 and C/EBPalpha. Journal of cellular biochemistry. 2015; 116(11):2658-2666.

31. Liang WC, Fu WM, Wong CW, Wang Y, Wang WM, Hu GX, Zhang L, Xiao LJ, Wan DC, Zhang JF and Waye MM. The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer. Oncotarget. 2015; 6(26):22513-22525.

32. Wang Y, Liang WC, Pan WL, Law WK, Hu JS, Ip DT, Waye MM, Ng TB and Wan DC. Silibinin, a novel chemokine receptor type 4 antagonist, inhibits chemokine ligand 12-induced migration in breast cancer cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2014; 21(11):1310-1317.

33. Wang Y, Law WK, Hu JS, Lin HQ, Ip TM and Wan DC. Discovery of FDA-approved drugs as inhibitors of fatty acid binding protein 4 using molecular docking screening. Journal of chemical information and modeling. 2014; 54(11):3046-3050.

34. Lin HQ, Wang Y, Chan KL, Ip TM and Wan CC. Differential regulation of lipid metabolism genes in the brain of acetylcholinesterase knockout mice. Journal of molecular neuroscience : MN. 2014; 53(3):397-408.

35. Liang WC, Wang Y, Xiao LJ, Wang YB, Fu WM, Wang WM, Jiang HQ, Qi W, Wan DC, Zhang JF and Waye MM. Identification of miRNAs that specifically target tumor suppressive KLF6-FL rather than oncogenic KLF6-SV1 isoform. RNA biology. 2014; 11(7):845-854.

36. Gu WG, Ip DT, Liu SJ, Chan JH, Wang Y, Zhang X, Zheng YT and Wan DC. 1,4-Bis(5-(naphthalen-1-yl)thiophen-2-yl)naphthalene, a small molecule, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular Lens epithelium-derived growth factor. Chemico-biological interactions. 2014; 213:21-27.

37. Zhou X, Wang Y, Hu T, Or PM, Wong J, Kwan YW, Wan DC, Hoi PM, Lai PB and Yeung JH. Enzyme kinetic and molecular docking studies for the inhibitions of miltirone on major human cytochrome P450 isozymes. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2013; 20(3-4):367-374.

38. Xu H-N, Lou J-Y, Zhang C, Liu H-M, Liu S-J, Wan DC-C, Wang Y, Lin H-Q and Hu C. Design, synthesis and biological activity of the novel acetylcholinesterase inhibitors 6-arylmethyl-3-(4-alkoxyphenyl)-7H-thiazolo[3, 2-b]-1, 2, 4-triazin-7-one derivatives. Chinese Journal of New Drugs. 2013; 22(22):2692-2697+2706.

39. Xu HN, Zhang L, Liu HM, Liu SJ, Lin HQ, Wang Y, Wan DCC and Hu C. Synthesis, Characterization and Biological Activity of 3-aryl-6-(4-fluorobenzyl)-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one Derivatives as Novel Acetylcholinesterase Inhibitors. Lat Am J Pharm. 2013; 32(7):953-959.

40. Wang Y, Pan WL, Liang WC, Law WK, Tsz-Ming Ip D, Ng TB, Miu-Yee Waye M and Chi-Cheong Wan D. Acetylshikonin, a Novel AChE Inhibitor, Inhibits Apoptosis via Upregulation of Heme Oxygenase-1 Expression in SH-SY5Y Cells. Evidence-based complementary and alternative medicine : eCAM. 2013; 2013:937370.

41. Liang WC, Wang Y, Wan DC, Yeung VS and Waye MM. Characterization of miR-210 in 3T3-L1 adipogenesis. Journal of cellular biochemistry. 2013; 114(12):2699-2707.

42. Zhou XL, Wang Y, Or PMY, Wan DCC, Kwan YW and Yeung JHK. Molecular docking and enzyme kinetic studies of dihydrotanshinone on metabolism of a model CYP2D6 probe substrate in human liver microsomes. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2012; 19(7):648-657.