杨博文，中国科学院上海硅酸盐研究所副研究员，硕士生导师。入选上海市青年科技启明星计划（A类）、中国科学院特聘研究岗位。博士毕业于中国科学院上海硅酸盐研究所（导师：施剑林）。研究工作主要围绕“纳米催化医学”，通过构建新型纳米颗粒，作为化学工具在病灶引发催化反应，调控局域活性氧浓度，以达到疾病化学干预的目的。近年来发展纳米催化抗氧化疗法，利用纳米催化剂高效清除人体活性氧，阻断下游生化反应，实现心血管疾病和各类炎症的抗氧化治疗。现以通讯/第一作者身份在J. Am. Chem. Soc.（4篇）、Angew. Chem. Int. Ed.（6篇）、Nat. Commun.（3篇）、Chem（2篇）、Adv. Mater.（4篇）、Acc. Chem. Res.（1篇）、Chem. Rev.（1篇）等期刊发表论文近40篇。7篇论文入选ESI高被引，总引用次数超过5000。主持国家自然科学基金面上项目、青年科学基金项目（C类）。获得中国科学院院长特别奖、中国化学会菁青化学星火奖、京博优秀博士论文奖等荣誉和奖励。连续多年入选爱思唯尔/斯坦福大学全球前2%顶尖科学家榜单（2022-2025）。协助指导的研究生获得国家奖学金、严东生奖学金、蓝长奖学金、中国科学院大学优秀学生等奖励或荣誉。

个人主页：上海硅酸盐研究所—介孔与低维纳米材料课题组

招生专业：材料科学与工程，化学，材料与化工

招生方向：无机非金属生物材料，纳米生物材料

1. 国家自然科学基金面上项目，2027.1-2030.12，主持

2. 国家自然科学基金青年科学基金项目（C类），2024.1-2026.12，主持

3. 上海市青年科技启明星计划（A类），2023.4-2026.3，主持

4. 关键陶瓷材料全国重点实验室主任基金重点项目，2026.7-2027.6，主持

5. 前沿基础研究部主任基金重点项目，2025.10-2027.9，主持

1. Di Jiang, Ruixuan He, Bowen Yang*, and Jianlin Shi. In-Situ Dynamic Chemical Reconstruction Synthesis of Dual-Antioxidants for Pulmonary Arterial Hypertension Treatment. Angewandte Chemie International Edition 2026, 65, e8724742. https://doi.org/10.1002/anie.8724742

2. Di Jiang, Ruixuan He, Bowen Yang*, and Jianlin Shi. A Nanosystem Manipulates Angiocrine Signaling for Cardioprotection in Male Mice by Relocalizing Endothelial Exosomes. Nature Communications 2026

3. Yufan Yao, Bowen Yang*, and Jianlin Shi*. TiOx(OH)4-2x Nanosheets with Catalytic Antioxidative Activity Alleviate Oxidative Injury in Diabetic Cardiomyopathy. Journal of the American Chemical Society 2025, 147, 3885-3895. https://doi.org/10.1021/jacs.4c18026

4. Bowen Yang* and Jianlin Shi*. Nanocatalytic Antioxidation: A General Chemical Approach for Alleviating Oxidative Stress in Diseases. Accounts of Chemical Research 2025, 58, 2708-2723. https://doi.org/10.1021/acs.accounts.5c00408

5. Bowen Yang and Jianlin Shi*. Generalized Concept of Catalysis for Chemical Reactions: Nanocatalysis in Medicine as a Paradigm. Chem 2025, 11, 102549. https://doi.org/10.1016/j.chempr.2025.102549

6. Di Jiang, Bowen Yang*, and Jianlin Shi. Antioxidative Therapy of Alcoholic Liver Injury by an Amorphous Two-Dimensional Cobalt Hydroxide Nanocatalyst. Angewandte Chemie International Edition 2025, 64, e202412031. https://doi.org/10.1002/anie.202412031

7. Bowen Yang, Chengkai Hu, Yuchong Zhang, Di Jiang, Peng Lin, Shouji Qiu, Jianlin Shi* and Lixin Wang*. Biomimetic-Structured Cobalt Nanocatalyst Suppresses Aortic Dissection Progression by Catalytic Antioxidation. Journal of the American Chemical Society 2024, 146, 17201-17210. https://doi.org/10.1021/jacs.4c03344

8. Jiacai Yang, Bowen Yang*, and Jianlin Shi*. A Nanomedicine-Enabled Ion-Exchange Strategy for Enhancing Curcumin-Based Rheumatoid Arthritis Therapy. Angewandte Chemie International Edition 2023, 62, e202310061. https://doi.org/10.1002/anie.202310061

9. Jiacai Yang, Heliang Yao, Yuedong Guo, Bowen Yang*, and Jianlin Shi*. Enhancing Tumor Catalytic Therapy by Co-Catalysis. Angewandte Chemie International Edition 2022, 61, e202200480. https://doi.org/10.1002/anie.202200480

10. Bowen Yang, Heliang Yao, Jiacai Yang, Chang Chen, and Jianlin Shi*. Construction of a Two-Dimensional Artificial Antioxidase for Nanocatalytic Rheumatoid Arthritis Treatment. Nature Communications 2022, 13, 1988. https://doi.org/10.1038/s41467-022-29735-1

11. Bowen Yang, Heliang Yao, Jiacai Yang, Chang Chen, Yuedong Guo, Hao Fu, and Jianlin Shi*. In Situ Synthesis of Natural Antioxidase Mimics for Catalytic Anti-Inflammatory Treatments: Rheumatoid Arthritis as an Example. Journal of the American Chemical Society 2022, 144, 314-330. https://doi.org/10.1021/jacs.1c09993

12. Bowen Yang, Heliang Yao, Han Tian, Zhiguo Yu, Yuedong Guo, Yuemei Wang, Jiacai Yang, Chang Chen, and Jianlin Shi*. Intratumoral Synthesis of Nano-Metalchelate for Tumor Catalytic Therapy by Ligand Field-Enhanced Coordination. Nature Communications 2021, 12, 3393. https://doi.org/10.1038/s41467-021-23710-y

13. Bowen Yang and Jianlin Shi*. Ascorbate Tumor Chemotherapy by an Iron-Engineered Nanomedicine-Catalyzed Tumor-Specific Pro-Oxidation. Journal of the American Chemical Society 2020, 142, 21775-21785. https://dx.doi.org/10.1021/jacs.0c09984

14. Bowen Yang, Yu Chen*, and Jianlin Shi*. Tumor-Specific Chemotherapy by Nanomedicine-Enabled Differential Stress Sensitization. Angewandte Chemie International Edition 2020, 59, 9693-9701. https://doi.org/10.1002/anie.202002306

15. Bowen Yang and Jianlin Shi*. Developing New Cancer Nanomedicines by Repurposing Old Drugs. Angewandte Chemie International Edition 2020, 59, 21829-21838. http://doi.org/10.1002/anie.202004317

16. Bowen Yang, Li Ding, Heliang Yao, Yu Chen*, and Jianlin Shi*. A Metal-Organic Framework (MOF) Fenton Nanoagent-Enabled Nanocatalytic Cancer Therapy in Synergy with Autophagy Inhibition. Advanced Materials 2020, 32, 1907152. https://doi.org/10.1002/adma.201907152

17. Bowen Yang, Yu Chen*, and Jianlin Shi*. Reactive Oxygen Species (ROS)-based Nanomedicine. Chemical Reviews 2019, 119, 4881-4985. https://doi.org/10.1021/acs.chemrev.8b00626

18. Bowen Yang, Yu Chen*, and Jianlin Shi*. Nanocatalytic Medicine. Advanced Materials 2019, 31, 1901778. https://doi.org/10.1002/adma.201901778

19. Bowen Yang, Junhui Yin, Yu Chen*, Shanshan Pan, Heliang Yao, Youshui Gao*, and Jianlin Shi* 2D-Black-Phosphorus-Reinforced 3D-Printed Scaffolds:A Stepwise Countermeasure for Osteosarcoma. Advanced Materials 2018, 30, 1705611. https://doi.org/10.1002/adma.201705611

施剑林，杨博文；重大疾病治疗的新视野——纳米催化医学；《探索先进材料的奥秘（2）》（韩雅芳，潘复生 主编）；中国科学技术大学出版社；2025: 30-36