Major: 

Biosensors and Bioelectronics (080920), Microelectronics (080903)         

Research Areas:

1. Electrophysiological / neurotransmitter chemical microelectrode array with nanotechnology, neuron pattern recognition and intelligent algorithm.

2. Brain scientific instruments for high-throughput neuron information detection and multilevel control; Acupoint neural information detection and stimulation therapy.

3.  Immunosensors / aptamer sensors for cancer biomarkers  point-of-care-testing (POCT) etc.

Ph.D. in Bioelectonics, Electronics & Electrical Engineering from Glasgow University, UK
M.Sc. in Microelectronics, Institute of Semiconductors, Chinese Academy of Sciences
B.Sc. in Microelectronics, Electrical Engineering Department, Beijing Institute of Technology

The 2nd class prize of national technical invention award in 2013 (No.1)
The 2nd class prize for progress of science and technology in Beijing in 2012 (No.1)
The national hundred, thousand and ten thousand talent project in 2014

Main Publications

https://www.researchgate.net/profile/Xinxia-Cai/publications

20 representative  publications：

1) Chengling Wu, Jingyu Xie, Qingxin Yao, Yilin Song, Gucheng Yang, Jie Zhao, Ruijia Zhang, Ting

Wang, Xingyu Jiang, Xinxia Cai*, Yuan Gao*, Intrahippocampal Supramolecular Assemblies Directed

Bioorthogonal Liberation of Neurotransmitters to Suppress Seizures in Freely Moving Mice, Advanced

Material, 2024, 23143102024 https://doi.org/10.1002/adma.202314310 (SCI, TOP, IF 29.4)

2) Shiya Lv, Fan Mo, Zhaojie Xu, Yu Wang, Gucheng Yang, Meiqi Han, Luyi Jing, Wei Xu, Yiming Duan,

Yaoyao Liu, Ming Li, Juntao Liu, Jinping Luo, Mixia Wang, Yilin Song*, Yirong Wu*, Xinxia Cai* ,

Tentacle Microelectrode Arrays Uncover Soft Boundary Neurons in Hippocampal CA1,  Advanced Science 2024, 2401670. (SCI, TOP, IF= 15.1). https://doi.org/10.1002/advs.202401670

3) Shiya Lv, Enhui He, Jinping Luo, Yaoyao Liu, Wei Liang, Shihong Xu, Kui Zhang, Yan Yang, Mixia

Wang, Yilin Song*, Yirong Wu*, Xinxia Cai*. Humaninduced pluripotent stem cell on micro-electrodearray

facilitates neural disease modeling in vitro: a review. Advanced Science, 2023, 10, 2301828.

https://doi.org/10.1002/advs.202301828. (SCI, TOP, IF 15.1)

4) Yaoyao Liu, Shihong Xu, Yan Yang, Kui Zhang, Enhui He, Wei Liang, Jinping Luo*, Yirong Wu*,

Xinxia Cai*. Nanomaterial-based microelectrodes array for in-vitro bidirectional brain-computer

interface: a review. Microsystems & Nanoengineering 2023, 9, 13. https://doi.org/10.1038/s41378-022-

00479-8.( SCI, TOP, IF 8.0)

5) Z. Xu, F. Mo, G. Yang, P. Fan, B. Lu, W. Liang, F. Kong, L. Jing, W. Xu, J. Liu, M. Wang*, Y. Wu*, X.

Cai*. Impaired spatial representations and electrophysiology in medial entorhinal cortex of the epileptic

rat detected by microelectrode arrays. Research, 2023, 6, 0229. https://doi.org/10.34133/research.0229

(SCI, TOP, IF 11）

6) M. Liu, J. Liu, W. Liang, B. Lu, P. Fan, Y. Song, M. Wang, Y. Wu*, X. Cai*. Recent Advances and

Research Development on Microsystems and Bioeffects of Terahertz Neuromodulation. Microsystems &

Nanoengineering, 2023，9, 143. https://doi.org/10.1038/s41378-023-00612-1 (SCI, TOP, IF 8.006）

7) Fan Mo, Fanli Kong, Gucheng Yang, Zhaojie Xu, Wei Liang, Juntao Liu, Kui Zhang, Yaoyao Liu, Shiya

Lv, Meiqi Han, Yu Wang, Yilin Song, Mixia Wang*, Yirong Wu*, Xinxia Cai*. Integrated threeelectrode

dual-mode detection chip for place cell analysis: dopamine facilitates the role of place cells in

encoding spatial locations of novel environments and rewards. ACS Sensors, 2023, 8, 12, 4765-4773.

https://doi.org/10.1021/acssensors.3c01864 (SCI, TOP, IF 9.6)

8) G. Yang, Y Wang, F. Mo, Xu Z, B. Lu, P. Fan, F. Kong, W. Xu, E. He, K. Zhang, J. Liu, X. Cai*.

PEDOT-citrate/SIKVAV modified bioaffinity microelectrode arrays for detecting theta rhythm cells in

the retrosplenial cortex of rats under sensory conflict， Sensors and Actuators B: Chemical, 2024,

399, 134802. (SCI, TOP, IF 8.4).

9) Y Liu, S Xu, Y Deng, J Luo, K Zhang, Y Yang, L Sha, R Hu, Z Xu, E Yin, Q Xu*, Y Wu*, X. Cai*,

SWCNTs/PEDOT:PSS nanocomposites-modified microelectrode arrays for revealing locking relations

between burst and local field potential in cultured cortical networks Biosensors and Bioelectronics,

2024, 253: 116168. (SCI, TOP, IF 12.6).

10) P Fan, R Zhang, G Xiao, Y Song, C Zhuang, L Yuan, F Mo, B Lu, Z Xu, Y Wang, J Luo, M Wang, W

Mi, J Cao*, Q Dai*, X Cai*. Simultaneous recording of neuronal discharge and calcium activity reveals

claustrum-cortex neurosynchrony under anesthesia, Fundamental Research, 2024, 2667-3258. (SCI, IF

6.2).

11) L Jing, Z Xu, P Fan, B Lu, F Mo, R Hu, W Xu, J Shan, Q Jia, Y Zhu, Y Duan, M Wang*, Y Wu*, X.

Cai*. Deep brain implantable microelectrode arrays for detection and functional localization of the

subthalamic nucleus in rats with Parkinson’s disease, Bio-design and Manufacturing. 2024, 1-14. (SCI,

TOP, IF 7.3)

12) Qianli Jia, Yiming Duan, Yaoyao Liu, Juntao Liu, Jinping Luo, Yilin Song, Zhaojie Xu, Kui Zhang, Jin

Shan, Fan Mo, Mixia Wang*, Ying Wang*, Xinxia Cai*, High-Performance Bidirectional

Microelectrode Array for Assessing Sevoflurane Anesthesia Effects and In Situ Electrical Stimulation in

Deep Brain Regions, ACS Sensors, 2024, https://doi.org/10.1021/acssensors.3c02676, (SCI, TOP,

IF=9.6)

13) Jingyu Xie, Yuchuan Dai, Yu Xing, Yiding Wang, Gucheng Yang, Enhui He, Zhaojie Xu, Penghui Fan, 

Fan Mo, Yirong Wu, Yilin Song*, Xinxia Cai*. PtNPs/rGO-GluOx/mPD directionally electroplated 

dual-mode microelectrode arrays for detecting the synergistic relationship between the cortex and 

hippocampus of epileptic rats. ACS Sensors, 2023, 8, 1810-1818. 

https://pubs.acs.org/doi/10.1021/acssensors.3c00140. (IF=9.6, TOP) 

14) Penghui Fan, Yiding Wang, Yuchuan Dai, Luyi Jing, Wei Liang, Botao Lu, Gucheng Yang, Yilin Song*, 

Yirong Wu*, Xinxia Cai*. Flexible microelectrode array probe for simultaneous detection of neural 

discharge and dopamine in striatum of mice aversion system. Sensors and Actuators B: Chemical, 

2023, 390, 133990. https://doi.org/10.1016/j.snb.2023.133990. (IF=9.2, TOP)

15) Botao Lu, Penghui Fan, Ming Li, Yiding Wang, Wei Liang, Gucheng Yang, Fan Mo, Zhaojie Xu, Jin 

Shan, Yilin Song, Juntao Liu*, Yirong Wu*, Xinxia Cai*. Detection of neuronal defensive discharges 

information transmission and characteristics in the periaqueductal gray double-subregions using 

PtNPs/PEDOT:PSS-modified microelectrode arrays. Microsystems & Nanoengineering, 2023, 9, 70. 

https://doi.org/10.1038/s41378-023-00546-8. (IF=8.0, TOP) 

16) Yang Wang, Jinping Luo, Juntao Liu, Shuai Sun, Ying Xiong, Yuanyuan Ma, Shi Yan, Yue Yang, 

Huabing Yin, Xinxia Cai*；Label-free microfluidic paper-based electrochemical aptasensor for 

ultrasensitive and simultaneous multiplexed detection of cancer biomarkers；Biosensors and 

Bioelectronics（SCI, IF=12.545,  TOP）；136(2019)；84~90 

17) Yan Fan, Juntao Liu, Yang Wang, Jinping Luo, Huiren Xu, Shengwei Xu, Xinxia Cai*；A wireless 

point-of-care testing system for the detection of neuron-specific enolase with microfluidic paper-based 

analytical devices；Biosensors & Bioelectronics（SCI, IF=12.545,  TOP ）；95(2017)；60~66 

18) Wentao Shi, Chunxiu Liu, Yilin Song, Nansen Lin, Shuai Zhou, Xinxia Cai*；An ascorbic acid 

amperometric sensor using over-oxidized polypyrrole and palladium nanoparticles composites；

Biosensors and Bioelectronics（SCI, IF=12.545, TOP ）；38(2012)；

100~106 

19) Song Zhang, Yilin Song, Mixia Wang, Guihua Xiao, Fei Gao, Ziyue Li, Guoxian Tao, Ping Zhuang, 

Feng Yue*, Piu Chan*, Xinxia Cai*；Real-time simultaneous recording of electrophysiological 

activities and dopamine overflow in the deep brain nuclei of a nonhuman primate with Parkinson’s 

disease using nano-based microelectrode arrays；Microsystems & Nanoengineering, （SCI, IF=8.006, 

​ TOP ）；4(2018), 17070，1~ 9 

20) Wenjing Wei, Yilin Song, Li Wang, Song Zhang, Jinping Luo, Shengwei Xu, Xinxia Cai*；An 

implantable microelectrode array for simultaneous L-glutamate and electrophysiological recordings in 

vivo；Microsystems and Nanoengineering（SCI, IF=8.006，TOP ）；

1(2015), 1~6