Name:       Xukai Zhou

Title:          Professor

Subject:     Organic Chemistry

Phone:       0411-39787214

Email:        xkzhou@dicp.ac.cn

Website:    http://rsd.dicp.ac.cn/

Address:    457, Zhongshan Road, Dalian, China, 116023

Research Areas

(1)    Selective activation of C-C/C-O bonds of biomass, and development of asymmetric catalysis approaches to            leverage biomass resources.

   (2)Exploration highly reactive catalysts for efficiently utilization of biomass energy to produce green hydrogen or                carbon-based fuels.


Education

2013/09-2018/06: Dalian Institute of Chemical Physics, CAS, Ph.D, Organic Chemistry

2009/09-2013/06: Hefei University of Technology, B.S., Applied Chemistry


Experience

2022/10-present: Dalian Institute of Chemical Physics, CAS, Professor

2022/07-2022/09: Dalian Institute of Chemical Physics, CAS, Associate Professor

2019/02-2022/06: The University of Chicago, Postdoctoral Fellowship


Publications

1.      Xukai Zhou, Yan Xu, and Guangbin Dong*. Deacylation-Aided C–H Alkylative Annulation through C–C Cleavage of Unstrained Ketones. Nat. Catal. 2021, 4, 703–710.

2.      Xukai Zhou, Tingting Yu, and Guangbin Dong*. Site-Specific and Degree-Controlled Alkyl Deuteration via Cu-Catalyzed Redox-Neutral Deacylation. J. Am. Chem. Soc. 2022, 144, 95709575.

3.      Xukai Zhou, Yan Xu, and Guangbin Dong*. Olefination via Cu-mediated Dehydroacylation of Unstrained Ketones. J. Am. Chem. Soc. 2021, 143, 2004220048.

4.      Xukai Zhou, Daniel Pyle, Zining Zhang, and Guangbin Dong*. Deacylative Thiolation by Redox-Neutral Aromatization-Driven CC Fragmentation of Ketones. Angew. Chem. Int. Ed. 2023, e202213691.

5.      Xukai Zhou, Jintao Xia, Guangfan Zheng, Lingheng Kong, and Xingwei Li*. Divergent Couplings of Anilines and Enones via Integration of C-H Activation and Transfer Hydrogenation. Angew. Chem. Int. Ed. 2018, 57, 6681-6685.

6.      Xukai Zhou, Yupeng Pan, and Xingwei Li*. Catalyst-Controlled Regiodivergent Alkyne Insertion in the Context of C-H Activation and Diels-Alder Reactions: Synthesis of Fused and Bridged Cycles. Angew. Chem. Int. Ed. 2017, 56, 8163-8167.

7.      Xukai Zhou, Yixin Luo, Lingheng Kong, Youwei Xu, Guangfan Zheng, Yu Lan,* and Xingwei Li* Cp*Co(III)-Catalyzed Branch-Selective Hydroarylation of Alkynes via C-H Activation: Efficient Access to α-gem-Vinylindoles. ACS Catal. 2017, 7, 72967304.

8.      Xukai Zhou, Songjie Yu, Lingheng Kong, and Xingwei Li* Rhodium(III)-Catalyzed Coupling of Arenes with Cyclopropanols via CH Activation and Ring Opening. ACS Catal. 2016, 6, 647651.

9.      Xiao-Yang Chen, Xukai Zhou (co-first author), Jianchun Wang, and Guangbin Dong*. FMPhos: Expanding the Catalytic Capacity of Small-Bite-Angle Bisphosphine Ligands in Regioselective Alkene Hydrofunctionalizations. ACS Catal. 2020, 10, 14349-14358.

10.   Xukai Zhou, Songjie Yu, Zisong Qi, Xingwei Li* Rhodium(III)-catalyzed [3+2] annulative coupling between oximes and electron-deficient alkynes. Sci China Chem, 2015, 58, 1297-1301. (hot paper)

11.   Xukai Zhou, Jiaqiong Sun, Xingwei Li* Chemo-selective couplings of anilines and acroleins/enones under substrate control and condition control. Chin. J. Catal. 2018, 39, 1782-1791.

12.   Xukai Zhou, Zisong Qi, Songjie Yu, Lingheng Kong, Yang Li, Wan-Fa Tian, and Xingwei Li*. Synthesis of 2-Substituted Quinolines via Rhodium(III)-Catalyzed C–H Activation of Imidamides and Coupling with Cyclopropanols. Adv. Synth. Catal. 2017, 359, 1620–1625 (selected as front cover picture)

13.   Xukai Zhou, Songjie Yu, Zisong Qi, Lingheng Kong, and Xingwei Li* Rhodium(III)-Catalyzed Mild Alkylation of (Hetero)Arenes with Cyclopropanols via CH Activation and Ring Opening. J. Org. Chem. 2016, 81, 48694875.


Research Interests

C-C bond activation; Radical chemistry; Photochemistry; Biomass transformation; Asymmetric catalysis


Honors & Distinctions

(1)  “Hundred Talents Program” of the Chinese Academy of Sciences, 2022

(2)  Zhang Dayu Youth Scholarship, 2022

(3)  Chinese Academy of Sciences (CAS) Presidential Scholarship, 2018

(4)  Outstanding graduates of Chinese Academy of Sciences, 2018

(5)  The first prize of YanChang Petroleum, 2018