080501-材料物理与化学

细菌靶向纳米材料，抗菌材料

2013-09--2018-06   中国科学院大学   工学博士
2009-09--2013-06   河海大学   工学学士

   

2021-07~现在, 中国科学院宁波材料技术与工程研究所, 副研究员
2018-09~2020-11,中国科学院宁波材料技术与工程研究所, 博士后
2018-07~2021-01,中国科学院大学宁波华美医院, 助理研究员

   

（ 1 ） 一种光疗纳米抗菌材料及其制备方法和应用, 发明专利, 2021, 第 4 作者, 专利号: CN202110895675.7

（ 2 ） 一种卤氧化铋抗菌材料及其制备方法和应用, 发明专利, 2021, 第 4 作者, 专利号: 中国

（ 3 ） 一种具有光热效应的钙硅基复合骨水泥及其制备方法和应用, 专利授权, 2021, 第 2 作者, 专利号: CN108653805B

（ 4 ） 一种广谱细菌靶向型磁共振成像造影剂及其制备方法和应用, 发明专利, 2020, 第 1 作者, 专利号: CN202011237671.1

（ 5 ） 靶向革兰氏阳性细菌的磁共振成像造影剂、制备和应用, 发明专利, 2020, 第 1 作者, 专利号: CN111450266A

（ 6 ） 一种经过还原的金属氧化物半导体纳米材料在抗菌材料中的应用, 发明专利, 2020, 第 3 作者, 专利号: CN202010514520.X

（ 7 ） 一种抗溃散钙硅基复合骨水泥及其制备方法和应用, 专利授权, 2019, 第 2 作者, 专利号: CN106693063B

   

[1] Haiyan Gu, Rui Shi, Chen Xu, Wenhao Lv, Xueyin Hu, Canxin Xu, Yuanbo Pan, Xiahong He, Aiguo Wu, Juan Li. EGFR-targeted liposomes combined with ginsenoside Rh2 inhibit triple-negative breast cancer growth and metastasis. BIOCONJUGATE CHEMISTRY[J]. 2023, 34: 1157-1165, [2] Lv, Wenhao, Xu, Chen, Wu, Hao, Zhu, Yangyang, Akakuru, Ozioma Udochukwu, Du, Hui, Nie, Fang, Wu, Aiguo, Li, Juan. Ultrasound-visualized nanocarriers with siRNA for targeted inhibition of M2-like TAM polarization to enhance photothermal therapy in NSCLC. NANO RESEARCH. 2022, http://dx.doi.org/10.1007/s12274-022-4767-7.
[3] Wang, Jiao, Zhang, Yexin, Kuang, Linlin, Yang, Jie, Xu, Chen, Mu, Baolin, Li, Jia, Lu, Peng, Song, Weijie, Wang, Wendong, Wu, Aiguo, Liang, Xiaozhen, Zhang, Jian. Low-voltage driven Ag-Co3O4 textile device for multifunctional air cleaning. CHEMICAL ENGINEERING JOURNAL[J]. 2021, 424: http://dx.doi.org/10.1016/j.cej.2021.130320.
[4] Lingchao Xiang, Ozioma Udochukwu Akakuru, Chen Xu, Aiguo Wu. Harnessing the Intriguing Properties of Magnetic Nanoparticles to Detect and Treat Bacterial Infections. MAGNETOCHEMISTRY[J]. 2021, 7(112): https://doaj.org/article/9a6fc222a58b47ada2c7b2801661006a.
[5] Xu, Chen, Li, Zihou, Akakuru, Ozioma udochukwu, Pan, Chunshu, Zou, Ruifen, Zheng, Jianjun, Wu, Aiguo. Maltodextrin-conjugated Gd-based MRI Contrast Agents for Specific Diagnosis of Bacterial Infections. ACS Applied Bio Materials[J]. 2021, [6] Pan, Chunshu, Lin, Junjie, Zheng, Jianjun, Liu, Chuang, Yuan, Bo, Akakuru, Ozioma Udochukwu, Zubair Iqbal, M, Fang, Qianlan, Hu, Jiapeng, Chen, Jia, Lin, Jie, Dai, Qi, Guo, Xiuyu, Li, Zihou, Zhang, Tao, Xu, Chen, Ma, Xuehua, Chen, Tianxiang, Wu, Aiguo, Jin, Yinhua. An intelligent T-1-T-2 switchable MRI contrast agent for the non-invasive identification of vulnerable atherosclerotic plaques dagger. NANOSCALE[J]. 2021, 13(13): 6461-6474, http://dx.doi.org/10.1039/d0nr08039j.
[7] Akakuru, Ozioma U, Xu, Chen, Liu, Chuang, Li, Zihou, Xing, Jie, Pan, Chunshu, Li, Yanying, Nosike, Elvis, I, Zhang, Zhoujing, Iqbal, Zubair M, Zheng, Jianjun, Wu, Aiguo. Metal-Free Organo-Theranostic Nanosystem with High Nitroxide Stability and Loading for Image-Guided Targeted Tumor Therapy. ACS NANO[J]. 2021, 15(2): 3079-3097, http://dx.doi.org/10.1021/acsnano.0c09590.
[8] 李娟, 徐晨, 余森. 面向人民生命健康的生物医用材料——生物医用材料分论坛侧记. 中国材料进展[J]. 2021, 40(10): 826-827, http://lib.cqvip.com/Qikan/Article/Detail?id=7106485474.
[9] Xu, Chen, Akakuru, Ozioma Udochukwu, Ma, Xuehua, Zheng, Jianping, Zheng, Jianjun, Wu, Aiguo. Nanoparticle-Based Wound Dressing: Recent Progress in the Detection and Therapy of Bacterial Infections. BIOCONJUGATE CHEMISTRY[J]. 2020, 31(7): 1708-1723, https://www.webofscience.com/wos/woscc/full-record/WOS:000551492900003.
[10] Gao, Long, Zhou, Yanling, Peng, Jinliang, Xu, Chen, Xu, Qing, Xing, Min, Chang, Jiang. A novel dual-adhesive and bioactive hydrogel activated by bioglass for wound healing. NPG ASIA MATERIALS[J]. 2019, 11(1): http://dx.doi.org/10.1038/s41427-019-0168-0.
[11] Xu, Chen, Akakuru, Ozioma Udochukwu, Zheng, Jianjun, Wu, Aiguo. Applications of Iron Oxide-Based Magnetic Nanoparticles in the Diagnosis and Treatment of Bacterial Infections. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY[J]. 2019, 7: https://doaj.org/article/8ab4251f2be548d7aae99355088db83f.
[12] Xu, Chen, Ma, Bing, Peng, Jinliang, Gao, Long, Xu, Yuhong, Huan, Zhiguang, Chang, Jiang. Tricalcium silicate/graphene oxide bone cement with photothermal properties for tumor ablation. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2019, 7(17): 2808-2818, https://www.webofscience.com/wos/woscc/full-record/WOS:000471328500006.
[13] Zhou, Yanling, Xu, Chen, Wang, Xiaoya, Dou, Yuandong, Huan, Zhiguang, Chang, Jiang. Fast setting tricalcium silicate/magnesium phosphate premixed cement for root canal filling. CERAMICS INTERNATIONAL[J]. 2018, 44(3): 3015-3023, http://dx.doi.org/10.1016/j.ceramint.2017.11.058.
[14] Xu, Chen, Wang, Xiaoya, Zhou, Jie, Huan, Zhiguang, Chang, Jiang. Bioactive tricalcium silicate/alginate composite bone cements with enhanced physicochemical properties. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS[J]. 2018, 106(1): 237-244, http://ir.sic.ac.cn/handle/331005/24607.
[15] Xu, Chen, Wen, Yang, Zhou, Yanling, Zhu, Yaqin, Dou, Yuandong, Huan, Zhiguang, Chang, Jiang. In vitro self-setting properties, bioactivity, and antibacterial ability of a silicate-based premixed bone cement. INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY[J]. 2018, 15(2): 460-471, http://ir.sic.ac.cn/handle/331005/24448.
[16] Wu, Tiantian, Xu, Chen, Du, Rong, Wen, Yang, Chang, Jiang, Huan, Zhiguang, Zhu, Yaqin. Effects of silicate-based composite material on the proliferation and mineralization behaviors of human dental pulp cells: An in vitro assessment. DENTAL MATERIALS JOURNAL[J]. 2018, 37(6): 889-896, https://www.webofscience.com/wos/woscc/full-record/WOS:000458340600004.
[17] Ma, Bing, Huan, Zhiguang, Xu, Chen, Ma, Nan, Zhu, Haibo, Zhong, Jipin, Chang, Jiang. Preparation and in vivo evaluation of a silicate-based composite bone cement. JOURNAL OF BIOMATERIALS APPLICATIONS[J]. 2017, 32(2): 257-264, http://ir.sic.ac.cn/handle/331005/25797.
[18] Huan, Zhiguang, Xu, Chen, Ma, Bing, Zhou, Jie, Chang, Jiang. Substantial enhancement of corrosion resistance and bioactivity of magnesium by incorporating calcium silicate particles. RSC ADVANCES[J]. 2016, 6(53): 47897-47906, http://www.irgrid.ac.cn/handle/1471x/1177189.

   

（ 1 ） 钆基磁共振成像探针用于脊柱细菌感染的靶向诊断与治疗研究, 负责人, 国家任务, 2021-01--2023-12
（ 2 ） 钆基细菌靶向探针的构建及其用于骨骼细菌感染成像的研究, 负责人, 地方任务, 2020-01--2022-12
（ 3 ） 钆基细菌靶向探针用于脊柱细菌感染特异性成像的研究, 负责人, 地方任务, 2019-06--2021-05
（ 4 ） 纳米生物探针在细菌感染疾病诊疗中的应用, 负责人, 企业委托, 2021-10--2022-09
（ 5 ） D型多肽自组装纳米探针关键技术及其肿瘤可视化治疗应用研究, 参与, 地方任务, 2020-07--2023-06
（ 6 ） 食管癌的早筛、诊断和监控液体活检技术, 参与, 地方任务, 2020-01--2024-12