研究方向为实验粒子物理。通过实验手段研究粒子的基本结构及其相互作用，从而揭示自然界物质的基本构成。目前参加位于北京正负电子对撞机的北京谱仪III实验项目和位于瑞士欧洲核子中心的LHCb实验项目。曾参加位于德国汉堡DESY国家实验室的HERMES实验项目。

2002年起参加位于德国DESY的国际高能实验HERMES合作组，参与HERMES软件开发测试，HERMES探测器增益监控系统，以及一系列重要的物理前沿热点研究，包括寻找奇异强子态和研究核子内部的横向极化结构。 

2008年起加入北京谱议BESIII实验国际合作组，参与BESIII的物理分析和软件开发工作。目前负责MDC带电径迹快速重建和事例起始时间测量系统，参与强子谱、粲耦素衰变，粲强子物理的研究工作。 曾任BESIII国际合作组会议报告遴选委员会秘书、主席。 现任BESIII国际合作组物理协调人职务。

2015年加入欧洲核子中心大型强子对撞机上的LHCb实验组，开展强子谱学、CP破坏和寻找新物理等方面研究。

发表科研论文列表详见inspirehep网站：
http://inspirehep.net/author/profile/Xiao.Rui.Lyu.1?ln=zh_CN
主要发表论文包括：

1. BESIII Collaboration, Measurement of the absolute branching fraction of inclusive decay Λc → Λ+X, Phys. Rev. Lett. 121, 062003 (2018) 
2. BESIII Collaboration, Measurements of absolute branching fractions for Λc→Ξ⁰K⁺ and Ξ(1530)⁰K⁺, Phys. Lett. B 783, 200 (2018)  
3. BESIII Collaboration, Study of the decays D⁺ → eta^(') e⁺ nu, Phys. Rev. D 97, 092009 (2018) 
4. BESIII Collaboration, Search for the rare decays D→ h(h')e⁺e^-, Phys. Rev. D 97, 072015 (2018) 
5. LHCb Collaboration, Measurement of the Lifetime of the Doubly Charmed Baryon Xi_cc⁺⁺, Phys. Rev. Lett. 121, 052002 (2018) 
6. LHCb Collaboration, First observation of the doubly charmed baryon decay Xi_cc⁺⁺→ Xic⁺pi⁺, arXiv:1807.01919 
7. LHCb Collaboration, Measurement of Upsilon production in pp collisions at sqrt(s)=13TeV, JHEP 07, 134 (2018)
8. BESIII Collaboration, Observation of the decay Λc +→ Σ−π+π+π0, Phys. Lett. B 772, 388 (2017).
9. BESIII Collaboration, Branching fraction measurements of ψ(3686)→γχcJ, Phys. Rev. D 96, 032001(2017) 
10. BESIII Collaboration, Search for the radiative leptonic decay D+→γe+νe, Phys. Rev. D 95, 071102(R) (2017)
11. BESIII Collaboration, Observation of Λc+ → nKsπ+, Phys. Rev. Lett. 118, 112001 (2017) 

12. BESIII Collaboration, Measurement of the absolute branching fraction for  Λc+ →  μ+ν, Phys. Lett. B 767, 42 (2017) 

13. LHCb Collaboration, Observation of the Doubly Charmed Baryon Ξcc++, Phys. Rev. Lett. 119, 112001 (2017) 

14. Dan Wang, Xiao-Rui Lyu et. al., Charmed baryon decay asymmetry in e+e- annihilation, Chin. Phys. C 41, 023106 (2017)
15. Qingnian Xu, Xiao-Rui Lyu et. al., Radiation studies for the MOMENT target station, Chin. Phys. C 40, 126001 (2016)
16. LHCb Collaboration, Measurement of the ratio of branching fractions B(Bc+ → J/ψK+)/B(Bc+ → J/ψπ+), Journal of HEP 09, 153 (2016)
17. BESIII Collaboration, Measurements of absolute hadronic branching fractions of Λc+ baryon, Phys. Rev. Lett. 116, 052001 (2016)
18. BESIII Collaboration, Measurement of azimuthal asymmetries in inclusive charged dipion production in e+e- annihilation at sqrt(s)=3.65 GeV, Phys. Rev. Lett. 116, 042001 (2016)
19. BESIII Collaboration, Measurement of the Absolute Branching Fraction for Λc→Λeν, Phys. Rev. Lett. 115, 221805 (2015)
20. BESIII Collaboration, Observation of a Neutral Structure near the DD* Mass Threshold in e+e−→ (DD*)⁰π⁰at √s=4.226 and 4.257GeV, Phys. Rev. Lett. 115, 222002 (2015)      
21. BESIII Collaboration, Observation of a Neutral Charmoniumlike State Zc(4025)0 in e+e−→ (D*D*)0π0, Phys. Rev. Lett. 115, 182002 (2015)
22. Xiao-Xia Liu, Xiao-Rui Lyu, Yong-Sheng Zhu, Combined estimation for multi-measurements of branching ratio, Chin. Phys. C39, 103001 (2015) 
23. BESIII Collaboration, Measurement of the branching fractions of Ds→η′X and Ds→η′ρ+ in e+e−→DsDs, Phys. Lett. B750, 466 (2015) 
24. BESIII Collaboration, Measurement of yCP in D0–D0 oscillation using quantum correlations in e+e−→D⁰D⁰at √s=3.773GeV, Phys. Lett. B744, 339 (2015) 
25. BESIII Collaboration, Measurement of the D→Kπ strong phase difference in ψ(3770)→D0D0, Phys. Lett. B734, 227 (2014)
26. BESIII Collaboration, Observation of a charged charmoniumlike structure in e+e−→ (D∗ D∗)±π∓ at sqrt(s)=4.26GeV, Phys. Rev. Lett.112, 132001 (2014) 
27. Ying-Hui Guan, Xiao-Rui Lu et. al., Study on Efficiency of Event Start Time Determination at BESIII, Chin. Phys. C38, 016201 (2014) 
28. Ying-Hui Guan, Xiao-Rui Lu et. al., Simultaneous least squares fitter based on the Lagrange multiplier method, Chin. Phys. C37, 106201 (2013) 
29. BESIII Collaboration, Evidence for ηc->γγ and measurement of J/ψ->3γ，Phys. Rev. D87, 032003 (2013) 
30.  Changli Ma, Xiao-Rui Lu et. al., An extended segment pattern dictionary for pattern matching tracking algorithm at BESIII, Chin. Phys. C37, 066202 (2013) 
31. BESIII Collaboration, Evidence for the Direct Two-Photon Transition from ψ(3686) to J/Ψ，Phys. Rev. Lett. 109, 172002 (2012) 
32. BESIII Collaboration, Observation of chi_cJ decays to Lambda Lamda pi+pi-，Phys. Rev. D86, 052004 (2012) 
33. Zhi-Guo He, Xiao-Rui Lu, Joan Soto, Yangheng Zheng, The discrete contribution to y'→ J/y+gg，Phys. Rev. D83, 054028 (2011) 
34. Xiao-Rui Lu, Study on the two-photon transition from psi(2S) to J/psi at BESIII, International Journal of Modern Physics A26, 552 (2011) 
35. 胡继峰，吕晓睿，郑阳恒，基于XML的粒子物理数据分析的接口及框架，核电子学与探测技术第8期，(2011) 
36. HERMES Collaboration, “Evidence for a Transverse Single-Spin Asymmetry in Leptoproduction of Pion Pairs,” Journal of High Energy Physics 0806, 017 (2008)
37. Xiao-Rui Lu (for the HERMES Collaboration), “Spin Structure of the Nucleon Studied at HERMES,” Proc. INPC2007, (Tokyo 2007), Nucl. Phys. A805, Volume 2, 129 (2008). 
38. HERMES Collaboration, “Longitudinal spin transfer to the Lambda hyperon in semi-inclusive deep-inelastic scattering,” Phys. Rev. D 74, 072004 (2006). 
39. HERMES Collaboration, “Evidence for a narrow |S| = 1 baryon state at a mass of 1528-MeV in quasi-real photoproduction,” Phys. Lett. B 585, 213 (2004)