(1) Isolation, identification and activity screening of marine natural products

(2) Mechanism research and druggability evaluation of Marine lead compounds

2008.07-present 
Research Assistant, Associate Professor (from 2010.12), and Professor (from 2018.12), 

South China Sea Institute of Oceanology, Chinese Academy of Sciences

2014.06-2015.06

Visiting scholar in Fenical's Lab, Scripps Institution of Oceanography, University of California at San Diego.

(49) Kunlong Li^#, Yu Dai^#, Jianglian She, Yanbo Zeng, Hao-fu Dai, Shunlin Ou*, Xuefeng Zhou*, Yonghong Liu*. Bisabolanoic acid A, a new polychiral sesquiterpene with AChE inhibitory activity from a mangrove-derived fungus Colletotrichum sp. Journal of Asian Natural Products Research. Accepted. DOI:10.1080/10286020.2021.1873297

(48) Yu Dai^#, Kunlong Li^#, Jianglian She, Yanbo Zeng, Hao Wang, Shengrong Liao, Xiuping Lin, Bin Yang, Junfeng Wang, Huaming Tao, Haofu Dai, Xuefeng Zhou, and Yonghong Liu. Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus Cochliobolus Lunatus SCSIO41401. Mar. Drugs. 2020, 18, 547.

(47) Yanhui Tan^#, Wende Deng^#, Yueyang Zhang, Minhong Ke, Binhua Zou, Xiaowei Luo, Jianbin Su, Yiyuan Wang, Jialan Xu, Kutty Selva Nandakumar, Yonghong Liu, Xuefeng Zhou* and Xiaojuan Li*. A marine fungus-derived nitrobenzoyl sesquiterpenoid suppresses RANKL-induced osteoclastogenesis and attenuates inflammatory bone destruction. British Journal of Pharmacology. 2020, 177: 4242–4260. (IF 7.73)

(46) Jianjiao Wang^#, Zhi Liang^#, Kunlong Li, Bin Yang, Yonghong Liu, Wei Fang*, Lan Tang*, Xuefeng Zhou*. Ene-yne Hydroquinones from a Marine-derived Strain of the Fungus Pestalotiopsis neglecta with Effects on Liver X Receptor Alpha. Journal of Natural Products. 2020, 83, 1258−1264 (Cover Article)

(45) Jianjiao Wang, Qingyun Peng, Xingang Yao, Yonghong Liu, Xuefeng Zhou*. New pestallic acids and diphenylketone derivatives from the marine alga-derived endophytic fungus Pestalotiopsis neglecta SCSIO41403. The Journal of Antibiotics. 2020, 73, 585-588.

(44) Li Kunlong, Cai Jian, Su Ziqi, Yang Bin, Liu Yonghong, Zhou Xuefeng*, Huang Jingxia* and Tao Huaming*. Glycosylated Natural

(42) Li Kunlong, Liang Zhi, Chen Weihao, Luo Xiaowei, Fang Wei, Liao Shengrong, Lin Xiuping, Yang Bin, Wang Junfeng, Tang Lan,* Liu Yonghong,* and Zhou Xuefeng*. Iakyricidins A‒D, antiproliferative piericidin analogs bearing carbonyl group or cyclic skeleton from Streptomyces iakyrus SCSIO NS104. The Journal of Organic Chemistry, 2019, 84 (19): 12626−12631. (Cover Article)

(41) Wang Jianjiao, Li Kunlong, Luo Xiaowei, Wu Zhaoyuan, Gu Tanwei, Liao Shengrong, Lin Xiuping, Yang Bin, Liu Yonghong, Fang Wei*, Zhou Xuefeng*.Sorbicillfurans A and B, two novel sorbicillinoid adducts from the fungus Penicillium citrinum SCSIO41402. Organic & Biomolecular Chemistry, 2019, 17: 8721−8725. (Cover Article)

(40) Lu Xianyuan, Dong Yaqian, Jian Zhichao, Li Qingyun, Gong Linna, Tang Lan, Zhou Xuefeng*, Liu Menghua*.Systematic investigation of the effects of long-term administration of a high-fat diet on drug transporters in the mouse liver, kidney and intestine. Current Drug Metabolism. 2019, 20: 742-755

(39) He Jingyu, Dong Yaqian, Liu Xiaoyan, Wan Yiling, Gu Tanwei, Zhou Xuefeng*, Liu Menghua*.Comparison of chemical compositions, antioxidant, and anti-photoaging activities of Paeonia suffruticosa flowers at different flowering stages. Antioxidants, 2019, 8(9), 345.

(38) Luo Xiaowei; Chen Chunmei; Tao Huaming; Lin Xiuping; Yang Bin; Zhou Xuefeng*; Liu Yonghong*. Structurally diverse diketopiperazine alkaloids from the marine-derived fungusAspergillus versicolor SCSIO 41016. Organic Chemistry Frontiers, 2019, 6: 736~740.

(37) Luo Xiao-Wei; Lin Yun; Lu Yong-Jun; Zhou Xue-feng*; Liu Yong-hong*. Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008. Chinese Journal of Natural Medicines, 2019, 17(2): 149~154.

(36) Lin Xiuping^#; Li Kunlong^#; Yang Lilin; Peng Xiaoying; Fang Wei; Tian Xinpeng*; Liu Yonghong; Zhou Xuefeng*. Dereplication and targeted isolation of bioactive sulphur compound from bacteria isolated from a hydrothermal field. Natural Product Research, 2019, 33(4): 494–499.

(35) Tan Suiyi^#; Yang Bin^#; Liu Juan; Xun Tianrong; Liu Yonghong; Zhou Xuefeng*. Penicillixanthone A, a marine-derived dual-coreceptor antagonist as anti-HIV-1 agent. Natural Product Research, 2019, 33(10): 1467-1471.

(34) Wang Jianjiao^#; Chen Feimin^#; Liu Yunhao; Liu Yuxuan; Li Kunlong; Yang Xiliang; Liu Shuwen*; Zhou Xuefeng*, Yang Jie*. Spirostaphylotrichin X from a marine-derived fungus as an anti-influenza agent targeting RNA polymerase PB2. Journal of Natural Products, 2018, 81(12): 2722~2730.(Top 20 Most Read Articles in December, 2018)

(33) Fang Wei; Wang Jianjiao; Wang Junfeng; Shi Liqiao; Li Kunlong; Lin Xiuping; Min Yong; Yang Bin; Tang Lan; Liu Yonghong; Zhou Xuefeng*. Cytotoxic and antibacterial eremophilane sesquiterpenes from the marine-derived fungus Cochliobolus lunatus SCSIO41401. Journal of Natural Products, 2018, 81(6): 1405~1410.

(32) Luo Xiaowei; Lin Xiuping; Tao Huaming; Wang Junfeng; Li Jiayi; Yang Bin;Zhou Xuefeng*; Liu Yonghong*. Isochromophilones A-F, cytotoxic chloroazaphilones from the marine mangrove endophytic fungus Diaporthe sp. SCSIO 41011. Journal of Natural Products, 2018, 81(4): 934~941.

(31) Tan Yanhui^#; Yang Bin^#; Lin Xiuping; Luo Xiaowei; Pang Xiaoyan; Tang Lan; Liu Yonghong; Li Xiaojuan*; Zhou Xuefeng*. Nitrobenzoyl sesquiterpenoids with cytotoxic activities from a marine-derived Aspergillus ochraceus fungus. Journal of Natural Products, 2018, 81(1): 92~97.

(30) Tian Yongqi; Lin Xiuping; Zhou Xuefeng*; Liu Yonghong*. Phenol derivatives from the sponge-derived fungus Didymellaceae sp. SCSIO F46. Frontiers in Chemistry, 2018, 6: 536.

(29) Luo Xiaowei^#; Yang Jie^#; Chen Feimin; Lin Xiuping; Chen Chunmei;Zhou Xuefeng*; Liu Shuwen*; Liu Yonghong*. Structurally diverse polyketides from the mangrove-derived fungus Diaporthe sp. SCSIO 41011 with their anti-influenza A virus activities. Frontiers in Chemistry, 2018, 6: 282.

(28) Yang Bin; Tao Huaming; Lin Xiuping; Wang Junfeng; Liao Shengrong; Dong Junde; Zhou Xuefeng*; Liu Yonghong*. Prenylated indole alkaloids and chromone derivatives from the fungus Penicillium sp SCSI0041218.Tetrahedron, 2018, 74(1): 77~82.

(27) Luo Xiaowei; Zhou Xuefeng*; Liu Yonghong*. Nitrogenous compounds produced by the deep sea derived fungus Leptosphaeria sp SCSIO 41005. Natural Product Communications, 2018, 13(6): 677~678.

2011-2017年

(26) Lin Xiuping^#; Wu Qinyu^#; Yu Yuying; Liang Zhi; Liu Yonghong; Zhou Lili*; Tang Lan*; Zhou Xuefeng*. Penicilliumin B, a novel sesquiterpene methylcyclopentenedione from a deep sea-derived Penicillium strain with renoprotective activities. Scientific Reports, 2017, 7: 10757.

(25) Luo Xiaowei; Lin Xiuping; Salendra Limbadri; Pang Xiaoyan; Dai Yu; Yang Bin; Liu Juan; Wang Junfeng; Zhou Xuefeng*; Liu Yonghong*.Isobenzofuranones and isochromenones from the deep-sea derived fungus Leptosphaeria sp SCSIO 41005. Marine Drugs, 2017, 15(7): 204.

(24) Yang Xiliang*; Peng Qingyun; Liu Qian; Hu Jie; Tang Zhipeng; Cui Lianjie; Lin Zonghao; Xu Bing; Lu Kuojian; Yang Fang; Sheng Zhizheng; Yuan Qiong; Liu Song; Zhang Jiuliang; Zhou Xuefeng*.Antioxidant activity against H₂O₂-induced cytotoxicity of the ethanol extract and compounds from Pyrola decorate leaves. Pharmaceutical Biology, 2017, 55(1): 1843~1848.

(23)Zhou Xuefeng^#; Fang Wei^#; Tan Suiyi^#; Lin Xiuping; Xun Tianrong; Yang Bingjie; Liu Shuwen*; Liu Yonghong*. Aspernigrins with anti-HIV-1 activities from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30. Bioorganic & Medicinal Chemistry Letters, 2016, 26(2): 361~365.

(22)Zhou Xuefeng; Fenical William*. The unique chemistry and biology of the piericidins. Journal of Antibiotics. 2016, 69(8): 582~593.

(21) Fang Wei^#; Lin Xiuping^#; Wang Jianjiao; Liu Yonghong; Tao Huaming*; Zhou Xuefeng*. Asperpyrone-type bis-naphtho-pyrones with COX-2-inhibitory activities from marine-derived fungus Aspergillus niger. Molecules, 2016, 21: 941.

(20) Fang Wei^#; Lin Xiuping^#; Zhou Xuefeng*; Wan Junting; Lu Xin; Yang Bin; Ai Wen; Lin Ji; Zhang Tianyu; Tu Zhengchao; Liu Yonghong*. Cytotoxic and antiviral nitrobenzoyl sesquiterpenoids from the marine-derived fungus Aspergillus ochraceus Jcma1F17. MedChemComm, 2014, 5(6): 701~705. (Cover Article)

(19) Fredimoses Mangaladoss^#;Zhou Xuefeng^#; Lin Xiuping; Tian Xinpeng; Ai Wen; Wang Junfeng; Liao Shengrong; Liu Juan; Yang Bin; Yang Xianwen; Liu Yonghong*.New prenylxanthones from the deep-Sea derived fungusEmericella sp. SCSIO 05240. Marine Drugs, 2014, 12(6): 3190~3202.

(18)Zhou Xuefeng; Sun Jianfan; Ma Wanlei; Fang Wei; Chen Zhefan; Yang Bin; Liu Yonghong*. Bioactivities of six sterols isolated from marine invertebrates. Pharmaceutical Biology, 2014, 52(2): 187~190.

(17)Zhou Xuefeng^#; Lin Xiuping^#; Ma Wanlei; Fang Wei; Chen Zhefang; Yang Bin; Liu Yonghong*. A new aromatic amine from fungus Pestalotiopsis vaccinii. Phytochemistry Letters, 2014, 7: 35~37.

(16)Zhou Xuefeng; Liu Juan; Yang Bin; Lin Xiuping; Yang Xian-Wen; Liu Yonghong*. Marine natural products with anti-HIV activities in the last decade.Current Medicinal Chemistry, 2013, 20(7): 953~973.

(15)Zhou Xuefeng; Lin Xiuping; Guo Xieyang; Yang Bin; Yang Xian-Wen; Liu Yonghong*.Chemical constituents of the sponge Mycalespecies from South China Sea. Records of Natural Products, 2013, 7(2): 119~123.

(14)Zhou Xuefeng; Lu Yanan; Lin Xiuping; Yang Bin; Yang Xian-Wen; Liu Yonghong*. Brominated aliphatic hydrocarbons and sterols from the sponge Xestospongia testudinaria with their bioactivities. Chemistry and Physics of Lipids, 2011, 164(7): 703~706.

(13)Xuefeng Zhou, Tunhai Xu, Yonghong Liu. Alisma orientale(Sam.) Juzep., a Common Traditional Chinese Medicine Plant as a Diuretic Agent. Recent Progress in Medicinal Plants Vol. 28: Drug Plants II. ISBN:1933699183, Houston: Studium Press LLC, 2010. P461~480.

(12)Zhou Xuefeng; Xu Tunhai; Yang Xian-Wen; Huang Riming; Yang Bin; Tang Lan; Liu Yonghong*. Chemical and biological aspects of marine sponges of the genus Xestospongia. Chemistry and Biodiversity, 2010, 7(9): 2201~2227.

(11)Zhou Xuefeng; Xu Tunhai; Wen Kewei; Yang Xian-Wen; Xu Shi-Hai*; Liu Yonghong*.New N-Acyl taurine from the sea urchin Glyptocidaris crenularis. Bioscience Biotechnology and Biochemistry, 2010, 74(5): 1089~1091.

(10)Zhou Xuefeng; Wen Kewei; Yang Xian-Wen; Huang Riming; Dong Guang; Yang Bin; Liu Yonghong*.Chemical constituents from the sea urchin Glyptocidaris crenularis. Biochemical Systematics and Ecology, 2010, 38(1): 103~105.

(9)Zhou Xuefeng; Liu Yonghong; Tang Lan; Zhang Peng*; Wu Jizhou.Chemical constituents from the roots of Actinidia chinensis. Chemistry of Natural Compounds, 2010, 46(2): 308~309.

(8)Zhou Xuefeng; Tang Lan*; Liu Yonghong.An isomeric mixture of novel cerebrosides isolated from Impatiens pritzellii reduces lipopolysaccharide-induced release of IL-18 from human peripheral blood mononuclear cells. Lipids, 2009, 44(8): 759~763.

(7)Zhou Xue-Feng; Tang Lan; Zhang Peng*; Zhao Xiao-Ya; Pi Hui-Fang; Zhang Yong-Hui; Wu Ji-Zhou.The interleukin-18 inhibitory activities of echinocystic acid and its saponins from Impatiens pritzellii var.hupehensis. Zeitschrift fur Naturforschung Section C-A Journal of Biosciences, 2009, 64(5-6): 369~372.

(6)Zhou Xue-Feng; Zhang Peng*; Pi Hui-Fang; Zhang Yong-Hui; Ruan Han-Li; Wang Hui; Wu Ji-Zhou. Triterpenoids from the roots of Actinidia chinensis. Chemistry and Biodiversity, 2009, 6(8): 1202~1207.

(5) 周雪峰,唐斓,张鹏,阮汉利,张勇慧,皮慧芳,吴继洲. 冷水七单体皂苷抗炎镇痛和免疫活性研究.中药药理与临床.2008, 24(1):27~28.

(4)Zhou Xue-Feng; Tang Lan; Zhang Yong-Hui; Pi Hui-Fang; Ruan Han-Li; Wu Ji-Zhou*. Nitrogenous compounds from Impatiens pritzellii var. hupehensis (Balsaminaceae). Biochemical Systematics and Ecology, 2007, 35(5): 308~310.

(3)Zhou Xue-Feng; Zhao Xiao-Ya; Tang Lan; Zhang Yong-Hui; Ruan Han-Li; Pi Hui-Fang; Qiu Jun; Wu Ji-Zhou*. Immunomodulatory activity of the rhizomes ofImpatiens pritzellii var.hupehensison collagen-induced arthritis mice. Journal of Ethnopharmacology, 2007, 109(3): 505~509. (2区Top)

(2)Zhou Xue-Feng; Zhao Xiao-Ya; Tang Lan; Ruan Han-Li; Zhang Yong-Hui; Pi Hui-Fang; Xiao Wei-Lie; Sun Han-Dong; Wu Ji-Zhou*.Three new triterpenoid saponins from the rhizomes of Impatiens pritzellii var. hupehensis. Journal of Asian Natural Products Research, 2007, 9(4): 379~385.

(1)周雪峰,尹仁杰,阮汉利,张勇慧,皮慧芳,赵晓亚,吴继洲.泽泻抑制尿草酸钙结石形成活性成分的2D NMR分析.波谱学杂志, 2005, 22(2):195~200.