研究方向：微生物系统代谢工程与合成生物学。首先系统认知微生物天然产物的代谢、调控网络，发掘有用的元、器件；然后利用这些认知基础，建立高产菌株工程改造、定向进化及高效筛选的新策略，进行需求导向的工业菌株开发，从而实现从“致知”到“致用”的研究。以第一或通讯作者在Nature Biotechnology, Science Advances, PNAS, Nature Communications, Science Bulletin, Current Opinion in Biotechnology等发表多篇文章；申请专利10余项，包括PCT专利2项。

     详见实验室主页：http://www.im.ac.cn/sklmr/index.php/team/index/203

2009-09--2013-06   中国科学院大学   理学博士学位
2006-09--2009-06   中国海洋大学   医学硕士学位
2002-09--2006-06   山东农业大学   理学学士学位

   

2019-08~现在, 中国科学院微生物研究所, 研究员
2016-09~2019-08,中国科学院微生物研究所, 副研究员
2013-06~2016-09,中国科学院微生物研究所, 助理研究员

2016年，入选中国科学院青年创新促进会。
2017年，获中国生物工程学会青年优秀论文一等奖。
2019年，获国家优秀青年科学基金项目资助。
2019年，获中科院青促会学术年会“学科交叉与创新奖”。
2020年，入选中国科学院青年创新促进会优秀会员。

   

[1] Zhang, Chaobo, Zhao, Youbao, Li, Zilong, Wang, Weishan, Huang, Ying, Pan, Guohui, Fan, Keqiang. Molecular mechanism of GylR-mediated regulation of glycerol metabolism in Streptomyces clavuligerus NRRL 3585. FRONTIERS IN MICROBIOLOGY[J]. 2022, 13: http://dx.doi.org/10.3389/fmicb.2022.1078293.
[2] 刘文溪, 李子龙, 闫浩, 张立新, 王为善. 异源重构白色链霉菌土霉素生产菌株. 微生物学报[J]. 2022, 62(10): 3858-3870, http://lib.cqvip.com/Qikan/Article/Detail?id=7108196806.
[3] Wang, Junyang, Li, Zilong, Wang, Weishan, Pang, Shen, Yao, Yongpeng, Yuan, Fang, Wang, Huizhuan, Xu, Zhen, Pan, Guohui, Liu, Zihe, Chen, Yihua, Fan, Keqiang. Dynamic Control Strategy to Produce Riboflavin with Lignocellulose Hydrolysate in the Thermophile Geobacillus thermoglucosidasius. ACS SYNTHETIC BIOLOGY[J]. 2022, 11(6): 2163-2174, http://dx.doi.org/10.1021/acssynbio.2c00087.
[4] 赵祥祥, 李珊珊, 刘光, 王忠, 杨志恒, 张权威, 梁敏东, 刘家坤, 李子龙, 童垚俊, 朱国良, 王馨叶, 蒋岚, 王为善, 谭高翼, 张立新. CaT-Smelor 2.0，一种耦合CRISPR-Cas12a与核酸适配体的多用生物传感检测平台. 科学通报:英文版[J]. 2021, 66(1): 69-77, http://lib.cqvip.com/Qikan/Article/Detail?id=7104049440.
[5] Yang, Yiying, Sun, Qingqing, Liu, Yang, Yin, Hanzhi, Yang, Wenping, Wang, Yang, Liu, Ying, Li, Yuxian, Pang, Shen, Liu, Wenxi, Zhang, Qian, Yuan, Fang, Qiu, Shiwen, Li, Jiong, Wang, Xuefeng, Fan, Keqiang, Wang, Weishan, Li, Zilong, Yin, Shouliang. Development of a pyrF-based counterselectable system for targeted gene deletion in Streptomyces rimosus. JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B[J]. 2021, 22(5): 383-396, http://dx.doi.org/10.1631/jzus.B2000606.
[6] Li, Shanshan, Li, Zilong, Pang, Shen, Xiang, Wensheng, Wang, Weishan. Coordinating precursor supply for pharmaceutical polyketide production in Streptomyces. CURRENT OPINION IN BIOTECHNOLOGYnull. 2021, 69: 26-34, http://dx.doi.org/10.1016/j.copbio.2020.11.006.
[7] Zhao, Xiangxiang, Li, Shanshan, Liu, Guang, Wang, Zhong, Yang, Zhiheng, Zhang, Quanwei, Liang, Mindong, Liu, Jiakun, Li, Zilong, Tong, Yaojun, Zhu, Guoliang, Wang, Xinye, Jiang, Lan, Wang, Weishan, Tan, GaoYi, Zhang, Lixin. A versatile biosensing platform coupling CRISPR-Cas12a and aptamers for detection of diverse analytes. SCIENCE BULLETIN[J]. 2021, 66(1): 69-77, http://dx.doi.org/10.1016/j.scib.2020.09.004.
[8] Yang, Zhiheng, Sun, Qingqing, Tan, Gaoyi, Zhang, Quanwei, Wang, Zhengduo, Li, Chuan, Qi, Fengxian, Wang, Weishan, Zhang, Lixin, Li, Zilong. Engineering thermophilic Geobacillus thermoglucosidasius for riboflavin production. MICROBIAL BIOTECHNOLOGY[J]. 2021, 14(2): 363-373, https://doaj.org/article/bd019966daf949cc98e749fa637d7ea6.
[9] Li, Shanshan, Yang, Bowen, Tan, GaoYi, Ouyang, LiMing, Qiu, Shiwen, Wang, Weishan, Xiang, Wensheng, Zhang, Lixin. Polyketide pesticides from actinomycetes. CURRENT OPINION IN BIOTECHNOLOGYnull. 2021, 69: 299-307, http://dx.doi.org/10.1016/j.copbio.2021.05.006.
[10] Zhang, Qian, Ren, JinWei, Wang, Weishan, Zhai, Jian, Yang, Jing, Liu, Ning, Huang, Ying, Chen, Yihua, Pan, Guohui, Fan, Keqiang. A Versatile Transcription-Translation in One Approach for Activation of Cryptic Biosynthetic Gene Clusters. ACS CHEMICAL BIOLOGY[J]. 2020, 15(9): 2551-2557, https://www.webofscience.com/wos/woscc/full-record/WOS:000574920900024.
[11] Wang, Weishan, Li, Shanshan, Li, Zilong, Zhang, Jingyu, Fan, Keqiang, Tan, Gaoyi, Ai, Guomin, Lam, Sin Man, Shui, Guanghou, Yang, Zhiheng, Lu, Hongzhong, Jin, Pinjiao, Li, Yihong, Chen, Xiangyin, Xia, Xuekui, Liu, Xueting, Dannelly, H Kathleen, Yang, Chen, Yang, Yi, Zhang, Siliang, Alterovitz, Gil, Xiang, Wensheng, Zhang, Lixin. Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces. NATURE BIOTECHNOLOGY[J]. 2020, 38(1): 76-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000510337700016.
[12] Cao, Zhixing, Yu, Jiaming, Wang, Weishan, Lu, Hongzhong, Xia, Xuekui, Xu, Hui, Yang, Xiuliang, Bao, Lianqun, Zhang, Qing, Wang, Huifeng, Zhang, Siliang, Zhang, Lixin. Multi-scale data-driven engineering for biosynthetic titer improvement. CURRENT OPINION IN BIOTECHNOLOGYnull. 2020, 65: 205-212, http://dx.doi.org/10.1016/j.copbio.2020.04.002.
[13] 张立新, 杨弋, 赵玉政, 王为善, 郑俊克, 李珊珊, 陈显军, 张敬宇, 刘雪婷, 谭高翼. 细胞工厂代谢转换机制及其智能生物制造. 中国基础科学[J]. 2020, 1-9, http://lib.cqvip.com/Qikan/Article/Detail?id=00002EGM55987JP0MPDO3JP1MNR.
[14] Wang, Xuefeng, Yin, Shouliang, Bai, Jing, Liu, Yang, Fan, Keqiang, Wang, Huizhuan, Yuan, Fang, Zhao, Baohua, Li, Zilong, Wang, Weishan. Heterologous production of chlortetracycline in an industrial grade Streptomyces rimosus host (vol 103, pg 6645, 2019). APPLIEDMICROBIOLOGYANDBIOTECHNOLOGYnull. 2020, 104(5): 2271-2272, https://www.webofscience.com/wos/woscc/full-record/WOS:000529946400035.
[15] Mindong Liang, Zilong Li, Weishan Wang, Jiakun Liu, Leshi Liu, Guoliang Zhu, Loganathan Karthik, Man Wang, KeFeng Wang, Zhong Wang, Jing Yu, Yuting Shuai, Jiaming Yu, Lu Zhang, Zhiheng Yang, Chuan Li, Qian Zhang, Tong Shi, Liming Zhou, Feng Xie, Huanqin Dai, Xueting Liu, Jingyu Zhang, Guang Liu, Ying Zhuo, Buchang Zhang, Chenli Liu, Shanshan Li, Xuekui Xia, Yaojun Tong, Yanwen Liu, Gil Alterovitz, GaoYi Tan, LiXin Zhang. A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules. NATURE COMMUNICATIONS[J]. 2019, 10(1): 1-9, http://gooa.las.ac.cn/external/index?type=-1&pid=1508733.
[16] Wang, Junyang, Wang, Weishan, Wang, Huizhuan, Yuan, Fang, Xu, Zhen, Yang, Keqian, Li, Zilong, Chen, Yihua, Fan, Keqiang. Improvement of stress tolerance and riboflavin production of Bacillus subtilis by introduction of heat shock proteins from thermophilic bacillus strains. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2019, 103(11): 4455-4465, https://www.webofscience.com/wos/woscc/full-record/WOS:000467209500016.
[17] 刘乐诗, 谭高翼, 王为善, 李珊珊, 夏雪奎, 刘昌衡, 代焕琴, 王泽建, 张嗣良, 张立新. 微生物，高智商，大产业——合成生物学助力阿维菌素的高效智能制造. 生命科学[J]. 2019, 31(5): 516-525, http://lib.cqvip.com/Qikan/Article/Detail?id=7002257301.
[18] Wang, Xuefeng, Yin, Shouliang, Bai, Jing, Liu, Yang, Fan, Keqiang, Wang, Huizhuan, Yuan, Fang, Zhao, Baohua, Li, Zilong, Wang, Weishan. Heterologous production of chlortetracycline in an industrial grade Streptomyces rimosus host. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2019, 103(16): 6645-6655, https://www.webofscience.com/wos/woscc/full-record/WOS:000477927800021.
[19] Zhang, Lu, Liu, Leshi, Wang, KeFeng, Xu, Lan, Zhou, Liming, Wang, Weishan, Li, Chuan, Xu, Zheng, Shi, Tong, Chen, Haihong, Li, Yuanhang, Xu, Hui, Yang, XiuLiang, Zhu, Zhichun, Chen, Biqin, Li, Dan, Zhan, Guanghuang, Zhang, SiLiang, Zhang, LiXin, Tan, GaoYi. Phosphate limitation increases coenzyme Q(10) production in industrial Rhodobacter sphaeroides HY01. SYNTHETIC AND SYSTEMS BIOTECHNOLOGY[J]. 2019, 4(4): 212-219, http://lib.cqvip.com/Qikan/Article/Detail?id=7103844777.
[20] Yin, Hanzhi, Wang, Weishan, Fan, Keqiang, Li, Zilong. Regulatory perspective of antibiotic biosynthesis in Streptomyces. SCIENCE CHINA-LIFE SCIENCES[J]. 2019, 62(5): 698-700, http://lib.cqvip.com/Qikan/Article/Detail?id=74678871504849574853484948.
[21] Cao, Jiaqian, Yao, Yongpeng, Fan, Keqiang, Tan, Gaoyi, Xiang, Wensheng, Xia, Xuekui, Li, Shanshan, Wang, Weishan, Zhang, Lixin. Harnessing a previously unidentified capability of bacterial allosteric transcription factors for sensing diverse small molecules in vitro. SCIENCE ADVANCES[J]. 2018, 4(11): http://dx.doi.org/10.1126/sciadv.aau4602.
[22] Li, Shanshan, Wang, Junyang, Xiang, Wensheng, Yang, Keqian, Li, Zilong, Wang, Weishan. An Autoregulated Fine-Tuning Strategy for Titer Improvement of Secondary Metabolites Using Native Promoters in Streptomyces. ACS SYNTHETIC BIOLOGY[J]. 2018, 7(2): 522-530, http://dx.doi.org/10.1021/acssynbio.7b00318.
[23] Yao, Yongpeng, Li, Shanshan, Cao, Jiaqian, Liu, Weiwei, Qi, Fengxian, Xiang, Wensheng, Yang, Keqian, Wang, Weishan, Zhang, Lixin. A novel signal transduction system for development of uric acid biosensors. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2018, 102(17): 7489-7497, https://www.webofscience.com/wos/woscc/full-record/WOS:000441229200023.
[24] Yao, Yongpeng, Li, Shanshan, Cao, Jiaqian, Liu, Weiwei, Fan, Keqiang, Xiang, Wensheng, Yang, Keqian, Kong, Deming, Wang, Weishan. Development of small molecule biosensors by coupling the recognition of the bacterial allosteric transcription factor with isothermal strand displacement amplification. CHEMICAL COMMUNICATIONS[J]. 2018, 54(38): 4774-4777, http://dx.doi.org/10.1039/c8cc01764f.
[25] Li, Xiao, Wang, Juan, Shi, Mingxin, Wang, Weishan, Corre, Christophe, Yang, Keqian. Evidence for the formation of ScbR/ScbR2 heterodimers and identification of one of the regulatory targets in Streptomyces coelicolor. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2017, 101(13): 5333-5340, https://www.webofscience.com/wos/woscc/full-record/WOS:000404146300011.
[26] Li, Shanshan, Zhou, Li, Yao, Yongpeng, Fan, Keqiang, Li, Zilong, Zhang, Lixin, Wang, Weishan, Yang, Keqian. A platform for the development of novel biosensors by configuring allosteric transcription factor recognition with amplified luminescent proximity homogeneous assays. CHEMICAL COMMUNICATIONS[J]. 2017, 53(1): 99-102, http://dx.doi.org/10.1039/c6cc07244e.
[27] Wang, Weishan, Yang, Tongjian, Li, Yihong, Li, Shanshan, Yin, Shouliang, Styles, Kathryn, Corre, Christophe, Yang, Keqian. Development of a Synthetic Oxytetracycline-Inducible Expression System for Streptomycetes Using de Novo Characterized Genetic Parts. ACS SYNTHETIC BIOLOGY[J]. 2016, 5(7): 765-773, http://www.corc.org.cn/handle/1471x/2374521.
[28] Jiang, Tianyu, Ke, Bowen, Chen, Hui, Wang, Weishan, Du, Lupei, Yang, Keqian, Li, Minyong. Bioluminescent Probe for Detecting Mercury(II) in Living Mice. ANALYTICAL CHEMISTRY[J]. 2016, 88(15): 7462-7465, [29] 尹守亮, 林智炜, 张玉秀, 王为善, 史明欣, 杨克迁. 工程改造龟裂链霉菌提高土霉素产量. 中国生物工程杂志[J]. 2016, 36(7): 72-82, http://lib.cqvip.com/Qikan/Article/Detail?id=683877174201607011.
[30] Yin, Shouliang, Li, Zilong, Wang, Xuefeng, Wang, Huizhuan, Jia, Xiaole, Ai, Guomin, Bai, Zishang, Shi, Mingxin, Yuan, Fang, Liu, Tiejun, Wang, Weishan, Yang, Keqian. Heterologous expression of oxytetracycline biosynthetic gene cluster in Streptomyces venezuelae WVR2006 to improve production level and to alter fermentation process. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2016, 100(24): 10563-10572, http://dx.doi.org/10.1007/s00253-016-7873-1.
[31] 姚永鹏, 王为善, 杨克迁. 链霉菌中高效生产聚酮化合物的研究方法及进展. 微生物学报[J]. 2016, 56(3): 418-428, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5642243&detailType=1.
[32] 王俊阳, 王为善, 赵华, 杨克迁. 细菌双杂交系统的改进. 生物工程学报[J]. 2016, 32(2): 231-240, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5634896&detailType=1.
[33] Sidda, John D, Poon, Vincent, Song, Lijiang, Wang, Weishan, Yang, Keqian, Corre, Christophe. Overproduction and identification of butyrolactones SCB1-8 in the antibiotic production superhost Streptomyces M1152. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2016, 14(27): 6390-6393, http://dx.doi.org/10.1039/c6ob00840b.
[34] Jiang, Tianyu, Wang, Weishan, Wu, Xingkang, Wu, Wenxiao, Bai, Haixiu, Ma, Zhao, Shen, Yuemao, Yang, Keqian, Li, Minyong. Discovery of New Substrates for LuxAB Bacterial Bioluminescence. CHEMICAL BIOLOGY & DRUG DESIGN[J]. 2016, 88(2): 197-208, https://www.webofscience.com/wos/woscc/full-record/WOS:000381035500004.
[35] Wang, Weishan, Li, Xiao, Li, Yue, Li, Shanshan, Fan, Keqiang, Yang, Keqian. A genetic biosensor for identification of transcriptional repressors of target promoters. SCIENTIFIC REPORTS[J]. 2015, 5: http://dx.doi.org/10.1038/srep15887.
[36] Li, Xiao, Wang, Juan, Li, Shanshan, Ji, Junjie, Wang, Weishan, Yang, Keqian. ScbR- and ScbR2-mediated signal transduction networks coordinate complex physiological responses in Streptomyces coelicolor. SCIENTIFIC REPORTS[J]. 2015, 5: https://www.webofscience.com/wos/woscc/full-record/WOS:000362344300002.
[37] Yin, Shouliang, Wang, Weishan, Wang, Xuefeng, Zhu, Yaxin, Jia, Xiaole, Li, Shanshan, Yuan, Fang, Zhang, Yuxiu, Yang, Keqian. Identification of a cluster-situated activator of oxytetracycline biosynthesis and manipulation of its expression for improved oxytetracycline production in Streptomyces rimosus. MICROBIAL CELL FACTORIES[J]. 2015, 14(1): http://dx.doi.org/10.1186/s12934-015-0231-7.
[38] Li, Shanshan, Wang, Weishan, Li, Xiao, Fan, Keqiang, Yang, Keqian. Genome-wide identification and characterization of reference genes with different transcript abundances for Streptomyces coelicolor. SCIENTIFIC REPORTS[J]. 2015, 5: http://dx.doi.org/10.1038/srep15840.
[39] Li, Shanshan, Wang, Junyang, Li, Xiao, Yin, Shouliang, Wang, Weishan, Yang, Keqian. Genome-wide identification and evaluation of constitutive promoters in streptomycetes. MICROBIAL CELL FACTORIES[J]. 2015, 14(1): http://dx.doi.org/10.1186/s12934-015-0351-0.
[40] 王俊阳, 王为善, 李肖, 赵华, 杨克迁. 转录调控研究的方法学进展. 生物工程学报[J]. 2015, 31(8): 1141-1150, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5488382&detailType=1.
[41] 李宜鸿, 李珊珊, 艾国民, 王为善, 张部昌, 杨克迁. 天蓝色链霉菌代谢物组测定方法优化及其代谢特征. 生物工程学报[J]. 2014, 第4期(4): 554-568, http://www.corc.org.cn/handle/1471x/2092180.
[42] Wang, Weishan, Ji, Junjie, Li, Xiao, Wang, Juan, Li, Shanshan, Pan, Guohui, Fan, Keqiang, Yang, Keqian. Angucyclines as signals modulate the behaviors of Streptomyces coelicolor. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2014, 111(15): 5688-5693, http://dx.doi.org/10.1073/pnas.1324253111.
[43] Liu, Zhanjun, Wang, Weishan, Zhu, Ying, Gong, Qianhong, Yu, Wengong, Lu, Xinzhi. Antibiotics at subinhibitory concentrations improve the quorum sensing behavior of Chromobacterium violaceum. FEMS MICROBIOLOGY LETTERS[J]. 2013, 341(1): 37-44, https://www.webofscience.com/wos/woscc/full-record/WOS:000316149500005.
[44] Wang, Weishan, Li, Xiao, Wang, Juan, Xiang, Sihai, Feng, Xiaozhou, Yang, Keqian. An Engineered Strong Promoter for Streptomycetes. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2013, 79(14): 4484-4492, http://dx.doi.org/10.1128/AEM.00985-13.
[45] 冯晓洲, 王为善, 任晓慧, 刘新利, 毛相朝, 杨克迁. 多杀菌素生物合成基因簇启动子探测和转录时序. 生物工程学报[J]. 2013, 29(7): 914-926, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=4891307&detailType=1.
[46] Wang, Weishan, Zheng, Baicun, Gong, Weiguang, Fu, Lefeng, Feng, Zhongjun. Interaction of polymethacrylate-g-PEO comb copolymers with natural bentonite in aqueous systems. MICRO & NANO LETTERS[J]. 2012, 7(7): 671-675, https://www.webofscience.com/wos/woscc/full-record/WOS:000306759800020.
[47] Wang, Weishan, Zheng, Baicun, Feng, Zhongjun, Deng, Zuiliang, Fu, Lefeng. Adsorption of Polycarboxylate-based Superplasticizer onto Natural Bentonite. JOURNAL OF ADVANCED CONCRETE TECHNOLOGY[J]. 2012, 10(10): 323-331, https://www.webofscience.com/wos/woscc/full-record/WOS:000314170400001.
[48] Fan, Keqiang, Pan, Guohui, Peng, Xiaojing, Zheng, Jianting, Gao, Wubin, Wang, Juan, Wang, Weishan, Li, Yue, Yang, Keqian. Identification of JadG as the B Ring Opening Oxygenase Catalyzing the Oxidative C-C Bond Cleavage Reaction in Jadomycin Biosynthesis. CHEMISTRY & BIOLOGY[J]. 2012, 19(11): 1381-1390, http://dx.doi.org/10.1016/j.chembiol.2012.09.009.
[49] Wang, Juan, Wang, Weishan, Wang, Linqi, Zhang, Guifeng, Fan, Keqiang, Tan, Huarong, Yang, Keqian. A novel role of 'pseudo' gamma-butyrolactone receptors in controlling gamma-butyrolactone biosynthesis in Streptomyces. MOLECULAR MICROBIOLOGY[J]. 2011, 82(1): 236-250, http://dx.doi.org/10.1111/j.1365-2958.2011.07811.x.
[50] 王为善, 邹姗姗, 尹守亮, 官倩红, 于文功. 具有群体感应抑制活性海洋放线菌的分离和鉴定. 微生物学通报[J]. 2009, 1372-1377, http://lib.cqvip.com/Qikan/Article/Detail?id=31660201.
[51] 史晓翀, 宫倩红, 于文功, 王为善, 魏岚. 一种AHL降解菌株的高效筛选方法. 中国海洋大学学报：自然科学版[J]. 2007, 37(5): 728-732, http://lib.cqvip.com/Qikan/Article/Detail?id=25507567.
[52] Shanshan Li, Zilong Li, GaoYi Tan, Zhenguo Xin, Weishan Wang. In vitro allosteric transcription factor-based biosensing. TRENDS IN BIOTECHNOLOGY. http://dx.doi.org/10.1016/j.tibtech.2023.03.001.

   

（ 1 ） 霉菌次级代谢调控机制和高产策略, 主持, 国家级, 2020-01--2022-12
（ 2 ） 基于原核生物别构转录因子的全新小分子检测方法研究, 主持, 国家级, 2018-01--2021-12
（ 3 ） 链霉菌中ScbR2类抗生素受体介导的信号转导机制研究, 主持, 国家级, 2016-01--2019-12
（ 4 ） 开发适用于链霉菌的新型诱导表达系统, 主持, 国家级, 2015-01--2017-12
（ 5 ） 链霉菌聚酮类药物高产菌工程改造策略研究——青促会, 主持, 部委级, 2016-01--2019-12