General

Shu Wang Ph.D., Professor Organic Chemistry
Email:wangshu@iccas.ac.cn
Telephone:010-62636680
Mobile phone:
Address:北京市海淀区中关村北一街2号
Postcode:100190
Research Areas
ØDesign, synthesis and properties of light-harvesting conjugated polymers
ØBiosensors based on the conjugated polymers
ØBioactive conjugated polymers and life chemistry
Education
1994: B.S., Hebei University
1999: Ph. D., Peking University
1999-2001: Postdoc, CAS Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences
Experience
Work Experience
2001-2004: Postdoc, Institute for Polymers and Organic Solids, University of California at Santa Barbara, USA
2004.10: Professor, Institute of Chemistry, Chinese Academy of Sciences
Publications
Papers
2009
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Single nucleotide polymorphism (SNP) genotyping using cationic conjugated polymers in homogeneous solution Xinrui Duan, Wei Yue, Libing Liu, Zhengping Li, Yuliang Li, Fuchu He, Daoben Zhu, Gangqiao Zhou* , Shu Wang* Nature Protocols 2009, 4, 984-991.
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An optical approach for drug screening based on light-harvesting conjugated polyelectrolytes Lingling An, Libing Liu, Shu Wang*, G. C. Bazan*, Angew. Chem. Int. Ed. 2009 48 4372-4375.
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Fluorescent logic signal-based multiplex detection of nucleases with the assembly of cationic conjugated polymer and branched DNA Xuli Feng Xinrui Duan Libing Liu Fude Feng Shu Wang* Yuliang Li Daoben Zhu Angew. Chem. Int. Ed. 2009 accepted
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Conjugated polyelectrolytes as new platforms for drug screening Lingling An Shu Wang* Chem. Asian J. 2009 accepted (Invited Focus Reviews)
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A new light-harvesting conjugated polyelectrolyte microgel for DNA and enzyme detections Xuli Feng Qingling Xu Libing Liu Shu Wang* Langmuir 2009 accepted (Invited article for 25th Year of Langmuir Special Issue -Molecular and Macromolecular Self Assemblies)
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Fluorescent DNA-poly(phenylenevinylene) hybrid hydrogels for monitoring drug release Hongwei Tang Xinrui Duan Xuli Feng Libing Liu Shu Wang* Yuliang Li Daoben Zhu Chem. Commun. 2009 641-643 (Hot Article inside front cover picture).
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Homogeneous and one-step fluorescent allele-specific PCR for SNP genotyping assays using conjugated polyelectrolytes Xinrui Duan Libing Liu Shu Wang* Biosensors and Bioelectronics 2009 24 2095-2099.
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Label-free homogeneous and fluorescence "turn-on" detection of protease using conjugated polyelectrolytes Lingling An Libing Liu Shu Wang* Biomacromolecules 2009 10 454-457.
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Fluorescence-amplifying assay for irradiated DNA lesions using water-soluble conjugated polymers Fude Feng Xinrui Duan Shu Wang* Macromol. Rapid Commun. 2009 30 147-151 (Cover picture)
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Magnetically assisted fluorescence ratiometric assays for adenosine deminase using water-soluble conjugated polymers Fang He Minghui Yu Shu Wang* Chin. Sci. Bull. 2009 54 1340-1344.
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Cationic conjugated polymers for homogeneous and sensitive fluorescence detection of hyaluronidase Lingling An Libing Liu Shu Wang* Sci. China Ser B-Chem. 2009 52 827-832. (invited for special issue of chemical sensors)
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Gadolinium (III) chelated conjugated polymer as a potential MRI contrast agent Qingling Xu Litao Zhu Minghui Yu Fude Feng Lingling An Chengfen Xing Shu Wang* Polymer 2009 accepted
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Water-soluble conjugated polyelectrolyte-based fluorescence enzyme coupling protocol for continuous and sensitive beta-galactosidase detection, Macromol. Chem. Phys. 2009, accepted (Invited for special issue of functional polymers)
2008
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Fluorescent conjugated polyelectrolyte as an indicator for convenient detection of DNA methylation Fude Feng Hongzhong Wang Lingli Han Shu Wang* J. Am. Chem. Soc. 2008 130 11338-11343.
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Ultrasensitive DNA detection using photonic crystals Mingzhu Li Fang He Qing Liao Jian Liu Lei Jiang Yanlin Song* Shu Wang* Daoben Zhu Angew. Chem. Int. Ed. 2008 47 7258-7262.
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Conjugated polyelectrolytes for label-free DNA microarrays Fang He Fude Feng Shu Wang* Trends Biotechnol. 2008 26 57-59.
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Direct visualization of glucose phosphorylation with a cationic polythiophene Yanli Tang Fude Feng Minghui Yu Lingling An Fang He Shu Wang* Yuliang Li Daoben Zhu G. C. Bazan* Adv. Mater. 2008 20 703-705.
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Fluorescent conjugated polyelectrolytes for biomacromolecule detections Fude Feng Fang He Lingling An Shu Wang* Yuliang Li Daoben Zhu Adv. Mater. 2008 20 2959-2964 (Research News).
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Selective and homogeneous fluorescent DNA detection by target-induced strand displacement using cationic conjugated polyelectrolytes Fang He Fude Feng Xinrui Duan Shu Wang* Yuliang Li Daoben Zhu Anal. Chem. 2008 80 2239-2243.
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Microorganism-based assemblies of luminescent conjugated polyelectrolytes Libing Liu Xinrui Duan Huibiao Liu Shu Wang* Yuliang Li Chem. Commun. 2008 5999-6001.
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Conjugated polyelectrolyte-DNA complexes for multi-color and one-tube SNP genotyping assays Xinrui Duan Shu Wang* Zhengping Li* Chem. Commun. 2008 1302-1304.
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Synthesis of a new water-soluble oligo(phenylenevinylene) containing tyrosine moiety for tyrosinase activity detection Xuli Feng Fude Feng Minghui Yu Fang He Qingling Xu Hongwei Tang Shu Wang* Yuliang Li Daoben Zhu. Org. Lett. 2008 10 5369-5372.
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Cationic conjugated polyelectrolyte/molecular beacon complex for sensitive sequence-specific and real-time DNA detection Xuli Feng Xinrui Duan Libing Liu Lingling An Fude Feng Shu Wang* Langmuir 2008 24 12138-12141.
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Conjugated polyelectrolytes for protein assay and manipulation of catalytic activity of enzyme Lingling An Shu Wang* Daoben Zhu* Chem. Asian J. 2008 3 1601-1606.
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Water-soluble dendritic conjugated polyfluorenes: synthesis characterization and interactions with DNA Minghui Yu Libing Liu Shu Wang* J. Polymer Sci. Polymer Chem. 2008 46 7462-7472.
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Design and synthesis of a new conjugated polyelectrolyte as a reversible pH sensor Qingling Xu Lingling An Minghui Yu Shu Wang* Macromol. Rapid Commun. 2008 29 390-395.
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Cationic conjugated polyelectrolyte-based fluorometric detection of copper(II) ions in aqueous solution Chengfen Xing Zhiqiang Shi* Minghui Yu Shu Wang* Polymer 2008 49 2698-2703.
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Highly selective fluorescence detection for mercury (II) ions in aqueous solution using water soluble conjugated polyelectrolytes Hanyan Lv Yanli Tang Wei Xu* Deqing Zhang Shu Wang* Daoben Zhu* Macromol. Rapid Commun. 2008 29 1467-1471.
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A conjugated polymers-based electrochemical DNA sensor: design and application of a multi-functional and water-soluble conjugated polymer Lanyong Zhang Huan Sun Di Li Shiping Song Chunhai Fan* Shu Wang* Macromol. Rapid Commun. 2008 29 1489-1494.
2007
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Continuous fluorometric assays for acetylcholinesterase activity and inhibition using conjugated polyelectrolytes. Fude Feng Yanli Tang Shu Wang* Yuliang Li Daoben Zhu Angew. Chem. Int. Ed. 2007 46 7882-7886.
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Cationic Conjugated polymer/DNA complexes for amplified fluorescence assays of nucleases and methyltransferase. Fude FengYanli Tang Fang He Minghui Yu Xinrui Duan Shu Wang* Yuliang Li Daoben Zhu Adv. Mater. 2007 19 3490-3495.
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A sensitive and Homogeneous SNP Detection Using Cationic Conjugated Polymers. Xinrui Duan Zhengping Li* Fang He Shu Wang* J. Am. Chem. Soc. 2007 129 4154-4155.
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Optical Detection of Mercury (II) in Aqueous Solutions Using Conjugated Polymers and Label-Free Oligonucleotides. Xingfen Liu Yanli Tang Lihua Wang Juan Zhang Shiping Song Chunhai Fan* Shu Wang* Adv.Mater. 2007 19 1471-1474.
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A New Strategy for Fluorescence Detection of Diels-Alder Reaction with Conjugated Polymers. Fang He Yanli Tang Minghui Yu Shu Wang* Yuliang Li Daoben Zhu Adv. Funct. Mater. 2007 17 996-1002.
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Fluorescence Ratiometric Assays of Hydrogen Peroxide and Glucose in Serum Using Conjugated Polyelectrolytes. Fang He Fude Feng Shu Wang* Yuliang Li Daoben Zhu. J. Mater. Chem. 2007 17 3702-3707.
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Water-Soluble Conjugated Polymers for Continuous and Sensitive Fluorescence Assays for Phosphatase and Peptidase. Lingling An Yanli Tang Fude Feng Fang He Shu Wang* J. Mater. Chem. 2007 17 4147-4152 (Highlighted by Chemistry World September 2007 pp C4)
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Nonionic Water-Soluble Crown Ether-Substituted Polyfluorene as Fluorescent Probe for Lead Ion Assays. Minghui Yu Fang He Yanli Tang Shu Wang* Yuliang Li Daoben Zhu Macromol. Rapid Commun. 2007 28 1333-1338.
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Single Base Pair Mismatch Detection Using Cationic Conjugated Polymers through Fluorescence Resonance Energy Transfer. Ning Tian Yanli Tang Qinghua Xu* Shu Wang*. Macromol. Rapid Commun. 2007 28 729-732.
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Fluorescence Turn-on Detection of Nitric Oxide in Aqueous Solution Using Cationic Conjugated Polyelectrolytes. Chengfen Xing Minghui Yu Shu Wang* Zhiqiang Shi* Yuliang Li Daoben Zhu. Macromol. Rapid Commun. 2007 28 241-245.
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Analyte-Induced Aggregation of a Water-Soluble Conjugated Polymer for Fluorescent Assay of Oxalic Acid. Huan Sun Fude Feng Minghui Yu Shu Wang* Macromol. Rapid Commun. 2007 28 1905-1911.
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Gold Nanoparticle-Based Monitoring of the Reduction of Oxidized to Reduced Glutathione Xiaorong He Zhifeng Zhong Yanbing Guo Jing Lv Jialiang Xu Mei Zhu Yuliang Li* Huibiao Liu Shu Wang* Yulan Zhu Daoben Zhu* Langmuir 2007 23 8815-8819.
2006
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Quadruplex to Duplex Transition of G-Rich Oligonucleotides Probed by Cationic Water Soluble Conjugated Polyelectrolytes. Fang He Yanli Tang Minghui Yu Fude Feng Lingling An Huan Sun Shu Wang* Yuliang Li Daoben Zhu Guillermo C. Bazan* J. Am. Chem. Soc. 2006,128 6764-6765.
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Direct Visualization of Enzymatic Cleavage and Oxidative Damage by Hydroxyl Radicals of Single-Stranded DNA with a Cationic Polythiophene Derivative. Yanli Tang Fude Feng Fang He Shu Wang* Yuliang Li Daoben Zhu. J. Am. Chem. Soc. 2006128 14972-14976.
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Multiply-Configurable Optical Logic Systems Based on Cationic Conjugated Polymer/DNA Assemblies. Yanli Tang Fang He Shu Wang* Yuliang Li Daoben Zhu Guillermo C. Bazan* Adv. Mater. 2006 18 2105-2110.
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Radical Scavenging Mediates Reversible Fluorescence Quenching of an Anionic Conjugated Polymer: Highly Sensitive Probe for Antioxidants. Yanli Tang Fang He Minghui Yu Shu Wang* Yuliang Li Daoben Zhu Chem. Mater. 2006 18 3605-3610.
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Fluorescent Amplifying Detection for Hydrogen Peroxide with Cationic Conjugated Polymers and Its Application to Glucose Sensing. Fang He Yanli Tang Minghui Yu Shu Wang*,Yuliang Li Daoben Zhu Adv. Funct. Mater. 2006 16 91-94.
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A Reversible and Highly Selective Fluorescent Sensor for Mercury (II) Using Poly(thiophene)s that Contain Thymine Moieties. Yanli Tang Fang He Minghui Yu Fude Feng Lingling An Huan Sun Shu Wang* Yuliang Li Daoben Zhu Macromol. Rapid Commun. 2006 27 389-392. (Highlighted by Macromol. Chem. Phys. 2006 207 1629-1632).
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Synthesis of Water-Soluble Dendritic Conjugated Polymers for Fluorescent DNA Assays. Minghui Yu Yanli Tang Fang He Shu Wang* Dagui Zheng Yuliang Li* Daoben Zhu Macromol. Rapid Commun. 2006 27 1739-1745.
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A Fluorescence Ratiometric Protein Assa y Using Light Harvesting Conjugated Polymers. Lingling An Yanli Tang Shu Wang* Yuliang Li Daoben Zhu Macromol. Rapid Commun. 2006 27 993-997.
2005
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Fluorescent Amplifying Recognition for DNA G-Quadruplex Folding with a Cationic Conjugated Polymer: a Platform for Homogeneous Potassium Detection,Fang He,Yanli Tang,Shu Wang*,Yuliang Li,Daoben Zhu J. Am. Chem. Soc. 2005,127 12343-12346.
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Gold nanoparticle-based fluorometric and colorimetric sensing of Cu(II) ion Xiaorong He Huibiao Liu Yuliang Li* Shu Wang* Yongjun Li Ning Wang Jinchong Xiao Xinhe Xu and Daoben Zhu* Adv. Mater. 2005 17 2811-2815.
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The fluorescence resonance energy transfer (FRET) gate: A time-resolved study,Qing-Hua Xu,Shu Wang,Alexander Mikhailovsky,Guillermo C. Bazan,Daniel Moses,Alan J. Heeger,Proc. Natl. Acad. Sci. USA 2005,102(3),530-535.
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Synthesis of cationic water-soluble light- harvesting dendrimers,Shu Wang,Hong Janice,Guillermo C. Bazan,Org. Lett. 2005,7 (10),1907-1910.
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Multilayer polymer light-emitting diodes: white-light emission with high efficiency Xiong Gong Shu Wang Daniel Moses Guillermo C. Bazan Alan J. Heeger Adv. Mater. 2005 17 2053-2058. (封面形式发表 highlighted as "News and Views" in Nature 437 327-328.)
2004
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Fluorescein Provides a Resonance Gate for FRET from Conjugated Polymers to DNA Intercalated Dyes,Shu Wang,Brent S. Gaylord,Guillermo C. Bazan,J. Am. Chem. Soc. 2004,126,5446-5451.
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Collective optical behavior of cationic water-soluble dendrimers,Shu Wang,Brent S. Gaylord,Guillermo C. Bazan,Adv. Mater. 2004,16 (23-24),2127-2132. (封面形式发表)
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Solvent-dependent aggregation of a water-soluble poly(fluorene) controls energy transfer to chromophore-labeled DNA,Shu Wang,G. C. Bazan,Chem. Commun. 2004, 2508-2509.
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Time-resolved energy transfer in DNA sequence detection using water-soluble conjugated polymers: The role of electrostatic and hydrophobic interactions,Qing-Hua Xu, Brent S. Gaylord,Shu Wang,Guillermo C. Bazan,Daniel Moses,Alan J. Heeger,Proc. Natl. Acad. Sci. USA 2004,101(32),11634-11639.
2003
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Optically Amplified RNA-Protein Detection Methods Using Light-Harvesting Conjugated Polymers,Shu Wang,G. C. Bazan,Adv. Mater. 2003,15 (17),1425-1428. (封面形式发表)
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Size-specific interactions between single- and double-stranded oligonucleotides and cationic water-soluble oligofluorenes,Wang Shu,Liu Bin,Gaylord Brent S, Bazan Guillermo C. Adv. Funct. Mater. 2003,13(6),463-467. (封面形式发表)
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Beyond superquenching: Hyper-efficient energy transfer from conjugated polymers to gold nanoparticles Chunhai Fan,Shu Wang,Guillermo C. Bazan,Kevin W. Plaxco,Alan J. Heeger,Proc. Natl. Acad. Sci. USA 2003,100(11),6297-6301.
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Shape Adaptable Water Soluble Conjugated Polymers,Bin Liu,Shu Wang,Guillermo C. Bazan,Alexander Mikhailovsky,J. Am. Chem. Soc. 2003,125(44),13306-13307.
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Effect of Chromophore-Charge Distance on the Energy Transfer Properties of Water-Soluble Conjugated Oligomers,Liu Bin,Gaylord Brent S,Wang Shu,Bazan Guillermo C. J. Am. Chem. Soc. 2003,125(22),6705-6714.
Students
崇辉 硕士研究生 070303-有机化学 80032-化学研究所
段新瑞 博士研究生 070303-有机化学 80032-化学研究所
徐庆岭 博士研究生 070303-有机化学 80032-化学研究所
朱春雷 硕士研究生 070303-有机化学 80032-化学研究所
温泉山 硕士研究生 070303-有机化学 80032-化学研究所
唐红伟 博士研究生 070303-有机化学 80032-化学研究所
邢成芬 博士研究生 070303-有机化学 80032-化学研究所
冯旭利 博士研究生 070303-有机化学 80032-化学研究所