主要研究病原感染与宿主免疫，在SCI刊物上发表论文30余篇(包括以第一/共第一/通讯/共通讯作者，在Cell, Nature, Nature Microbiology, Science Translational Medicine, Cell Host & Microbe, Journal of Virology等杂志发表研究论文)，申请专利9项，揭示MERS-CoV、SARS-CoV-2等冠状病毒受体识别机制及跨种传播机制(Cell, Nature, Cell Host & Microbe, Journal of Virology)，研究寨卡病毒及裂谷热病毒等引起新发突发疫情的病原微生物的人体B细胞应答规律及抗体干预(Science Translational Medicine， Nature Microbiology)，为寨卡病毒等黄病毒、裂谷热病毒的疫苗设计提供重要理论基础，为其引发疾病的治疗提供重要的候选药物。

   

100102-免疫学

新发、突发传染病，尤其冠状病毒相关疾病的致病机制和干预手段
肿瘤病毒的治疗和干预手段

2006-09--2012-01   中国科学院生物物理研究所   博士学位
2002-09--2006-07   哈尔滨工业大学   学士学位

   

2019-11~现在, 中国科学院微生物研究所, 研究员
2015-10~2019-11,中国科学院微生物研究所, 副研究员
2014-07~2015-09,中国科学院微生物研究所, 助理研究员
2012-02~2014-06,中国科学院微生物研究所, 博士后

2020-05-01-今,中国生物工程学会抗体工程专业委员会（筹）, 秘书长
2016-12-01-今,中国研究型医院学会空间微生物学与感染专业委员会, 青年委员
2016-06-01-今,中国生物工程学会, 青年工作委员会委员
2016-05-31-今,中国科学技术协会, 第九届全国委员会委员

   

（1） 入选2018年“中国科学院青年创新促进会”, , 其他, 2018
（2） 中源协和生命医学创新突破奖, 其他, 2017
（3） 2016年中国科学院病原微生物与免疫学重点实验室科研成就奖, 研究所（学校）, 2016
（4） 2016年中科院微生物生理与代谢工程重点实验室优秀报告, 研究所（学校）, 2016

[1] 高福, 王奇慧, 仵丽丽, 郑安琪, 孙欢, 柴彦, 韩鹏程. 一种抗新型冠状病毒的多肽及其应用. ZL202110939740.1, 2022-11-18.
[2] 王奇慧, 高福, 刘红辉, 刘博, 仵丽丽, 韩鹏程. 纳米抗体R14的构建体及其应用. ZL202210375857.6, 2022-11-15.
[3] 高福, 严景华, 李燕, 仵丽丽, 王奇慧, 马素芳. 黄病毒抗体及其应用. CN: CN113683691A, 2021-11-23.
[4] 高福, 严景华, 李燕, 仵丽丽, 王奇慧, 戴连攀, 马素芳. 针对黄热病毒NS1蛋白的抗体及其应用. CN: CN113683690A, 2021-11-23.
[5] 高福, 严景华, 李燕, 仵丽丽, 王奇慧, 马素芳. 黄热病毒抗体及其应用. CN: CN113621058A, 2021-11-09.
[6] 严景华, 史瑞, 王奇慧, 齐建勋, 高福. 与新型冠状病毒的抗体有效结合的表位. CN: CN113527444A, 2021-10-22.
[7] 严景华, 史瑞, 王奇慧, 高福, 马素芳. 新型冠状病毒的人源单克隆抗体及其应用. CN: CN113444169A, 2021-09-28.
[8] 严景华, 史瑞, 王奇慧, 高福. 冠状病毒的人源单克隆抗体及其应用. CN: CN113354731A, 2021-09-07.
[9] 韩鹏程, 王奇慧, 高福. 针对新型冠状病毒的人ACE2改造蛋白、ACE2-hFc类抗体蛋白. CN: CN112794918A, 2021-05-14.
[10] 高福, 戴连攀, 严景华, 徐坤, 韩雨旋, 王奇慧, 黄庆瑞, 李金和. 一种寨卡/登革疫苗及其应用. CN: CN112194712A, 2021-01-08.
[11] 严景华, 王奇慧, 马桐, 杨化冰, 高福, 马素芳. 一种裂谷热病毒人源单克隆抗体及其应用. CN: CN109734800B, 2020-11-06.
[12] 高福, 严景华, 王奇慧, 仝舟. 一种高中和活性的寨卡病毒人源单克隆抗体及其应用. CN: CN110172095A, 2019-08-27.
[13] 高福, 严景华, 王奇慧, 仝舟. 一种寨卡病毒特异性中和抗体及其应用. CN: CN110066333A, 2019-07-30.
[14] 严景华, 王奇慧, 马桐, 杨化冰, 高福, 马素芳. 一种裂谷热病毒人源单克隆抗体及其应用. CN: CN109734800A, 2019-05-10.
[15] 王奇慧, 严景华, 高福. 一种黄病毒人源单克隆抗体及应用. CN: CN106589116A, 2017-04-26.
[16] 高福, 严景华, 王奇慧, 仝舟. 一种寨卡病毒人源单克隆抗体及其应用. CN: CN106279409A, 2017-01-04.

   

[1] Xiaoyun Wang, Yufeng Xie, Honghui Liu, Wenwen Lei, Ke Xu, Lili Wu, Ruiwen Fan, Guizhen Wu, George Fu Gao, Qihui Wang. A broadly neutralizing nanobody targeting the highly conserved S2 subunit of sarbecoviruses. SCIENCE BULLETIN[J]. 2023, 68(7): 684-687, http://dx.doi.org/10.1016/j.scib.2023.03.027.
[2] Qian Chen, Pei Du, Yuxuan Han, Xuehui Ma, Rong Zhang, Xiaoyu Rong, Xu Zhao, Renyi Ma, Huiting Yang, Anqi Zheng, Qingrui Huang, Jinghua Yan, Hui Wang, Xin Zhao, Lianpan Dai, George F Gao, Qihui Wang. Rapid evaluation of heterologous chimeric RBD-dimer mRNA vaccine for currently-epidemic Omicron sub-variants as booster shot after inactivated vaccine. BIOSAFETY AND HEALTH[J]. 2023, 5(2): 89-100, http://dx.doi.org/10.1016/j.bsheal.2023.02.002.
[3] Honghui Liu, Lili Wu, Bo Liu, Ke Xu, Wenwen Lei, Jianguo Deng, Xiaoyu Rong, Pei Du, Lebing Wang, Dongbin Wang, Xiaolong Zhang, Chao Su, Yuhai Bi, Hua Chen, William J Liu, Jianxun Qi, Qingwei Cui, Shuhui Qi, Ruiwen Fan, Jingkun Jiang, Guizhen Wu, George F Gao, Qihui Wang. Two pan-SARS-CoV-2 nanobodies and their multivalent derivatives effectively prevent Omicron infections in mice. CELL REPORTS MEDICINE[J]. 2023, 4(2): 100918-100918, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9834170/.
[4] Qingwen He, Lili Wu, Zepeng Xu, Xiaoyun Wang, Yufeng Xie, Yan Chai, Anqi Zheng, Jianjie Zhou, Shitong Qiao, Min Huang, Guijun Shang, Xin Zhao, Youjun Feng, Jianxun Qi, George Fu Gao, Qihui Wang. An updated atlas of antibody evasion by SARS-CoV-2 Omicron sub-variants including BQ.1.1 and XBB. CELL REPORTS MEDICINE[J]. 2023, 4(4): http://dx.doi.org/10.1016/j.xcrm.2023.100991.
[5] Hu, Yu, Liu, Kefang, Han, Pu, Xu, Zepeng, Zheng, Anqi, Pan, Xiaoqian, Jia, Yunfei, Su, Chao, Tang, Lingfeng, Wu, Lili, Bai, Bin, Zhao, Xin, Tian, Di, Chen, Zhihai, Qi, Jianxun, Wang, Qihui, Gao, George F. Host range and structural analysis of bat-origin RshSTT182/200 coronavirus binding to human ACE2 and its animal orthologs. EMBO JOURNAL[J]. 2023, 42(4): http://dx.doi.org/10.15252/embj.2022111737.
[6] Su, Chao, He, Juanhua, Han, Pengcheng, Bai, Bin, Li, Dedong, Cao, Jian, Tian, Mingxiong, Hu, Yu, Zheng, Anqi, Niu, Sheng, Chen, Qian, Rong, Xiaoyu, Zhang, Yanfang, Li, Weiwei, Qi, Jianxun, Zhao, Xin, Yang, Mengsu, Wang, Qihui, Gao, George Fu. Molecular Basis of Mink ACE2 Binding to SARS-CoV-2 and Its Mink-Derived Variants. JOURNAL OF VIROLOGY[J]. 2022, 96(17): http://dx.doi.org/10.1128/jvi.00814-22.
[7] Huang, Min, Wu, Lili, Zheng, Anqi, Xie, Yufeng, He, Qingwen, Rong, Xiaoyu, Han, Pu, Du, Pei, Han, Pengcheng, Zhang, Zengyuan, Zhao, Runchu, Jia, Yunfei, Li, Linjie, Bai, Bin, Hu, Ziliang, Hu, Shixiong, Niu, Sheng, Hu, Yu, Liu, Honghui, Liu, Bo, Cui, Kaige, Li, Weiwei, Zhao, Xin, Liu, Kefang, Qi, Jianxun, Wang, Qihui, Gao, George Fu. Atlas of currently available human neutralizing antibodies against SARS-CoV-2 and escape by Omicron sub-variants BA.1/BA.1.1/BA.2/BA.3. IMMUNITY[J]. 2022, 55(8): 1501-+, http://dx.doi.org/10.1016/j.immuni.2022.06.005.
[8] Jia, Yunfei, Niu, Sheng, Hu, Yu, Chai, Yan, Zheng, Anqi, Su, Chao, Wu, Lili, Han, Pengcheng, Han, Pu, Lu, Dan, Liu, Zhimin, Yan, Xinxi, Tian, Di, Chen, Zhihai, Qi, Jianxu, Tian, Wenxia, Wang, Qihui, Gao, George Fu. Cross-reaction of current available SARS-CoV-2 MAbs against the pangolin-origin coronavirus GX/P2V/2017. CELL REPORTS[J]. 2022, 41(11): http://dx.doi.org/10.1016/j.celrep.2022.111831.
[9] Li, Shihua, Yang, Ruirui, Zhang, Di, Han, Pu, Xu, Zepeng, Chen, Qian, Zhao, Runchu, Zhao, Xin, Qu, Xiao, Zheng, Anqi, Wang, Liang, Li, Linjie, Hu, Yu, Zhang, Rong, Su, Chao, Niu, Sheng, Zhang, Yanfang, Qi, Jianxun, Liu, Kefang, Wang, Qihui, Gao, George F. Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals. NATIONAL SCIENCE REVIEW[J]. 2022, 9(9): 161-172, http://dx.doi.org/10.1093/nsr/nwac122.
[10] Xu, Zepeng, Kang, Xinrui, Han, Pu, Du, Pei, Li, Linjie, Zheng, Anqi, Deng, Chuxia, Qi, Jianxun, Zhao, Xin, Wang, Qihui, Liu, Kefang, Gao, George Fu. Binding and structural basis of equine ACE2 to RBDs from SARS-CoV, SARS-CoV-2 and related coronaviruses. NATURE COMMUNICATIONS[J]. 2022, 13(1): https://doaj.org/article/b2d7bd70a2634ce28943fb8ccea2bf04.
[11] Pei Du, George Fu Gao, Qihui Wang. The mysterious origins of the Omicron variant of SARS-CoV-2. The Innovation[J]. 2022, 3(2): 100206-4, http://lib.cqvip.com/Qikan/Article/Detail?id=7107049763.
[12] Zhennan Zhao, Jingya Zhou, Mingxiong Tian, Min Huang, Sheng Liu, Yufeng Xie, Pu Han, Chongzhi Bai, Pengcheng Han, Anqi Zheng, Lutang Fu, Yuanzhu Gao, Qi Peng, Ying Li, Yan Chai, Zengyuan Zhang, Xin Zhao, Hao Song, Jianxun Qi, Qihui Wang, Peiyi Wang, George F Gao. Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape. NATURE COMMUNICATIONS[J]. 2022, 13(1): 1-12, https://doaj.org/article/90e8f270726e4bf38984d7f2e5f9e902.
[13] Zheng, Anqi, Wu, Lili, Ma, Renyi, Han, Pu, Huang, Baoying, Qiao, Chengpeng, Wang, Qihui, Tan, Wenjie, Gao, George F, Han, Pengcheng. A binding-enhanced but enzymatic activity-eliminated human ACE2 efficiently neutralizes SARS-CoV-2 variants. SIGNAL TRANSDUCTION AND TARGETED THERAPY[J]. 2022, 7(1): 362-365, http://dx.doi.org/10.1038/s41392-021-00821-y.
[14] Niu, Sheng, Wang, Jia, Bai, Bin, Wu, Lili, Zheng, Anqi, Chen, Qian, Du, Pei, Han, Pengcheng, Zhang, Yanfang, Jia, Yunfei, Qiao, Chengpeng, Qi, Jianxun, Tian, Wenxia, Wang, HongWei, Wang, Qihui, Gao, George Fu. Molecular basis of cross-species ACE2 interactions with SARS-CoV-2-like viruses of pangolin origin. EMBO JOURNAL[J]. 2021, 40(16): http://dx.doi.org/10.15252/embj.2021107786.
[15] Zhang, Zengyuan, Zhang, Yanfang, Liu, Kefang, Li, Yan, Lu, Qiong, Wang, Qingling, Zhang, Yuqin, Wang, Liang, Liao, Hanyi, Zheng, Anqi, Ma, Sufang, Fan, Zheng, Li, Huifang, Huang, Weijin, Bi, Yuhai, Zhao, Xin, Wang, Qihui, Gao, George F, Xiao, Haixia, Tong, Zhou, Qi, Jianxun, Sun, Yeping. The molecular basis for SARS-CoV-2 binding to dog ACE2. NATURE COMMUNICATIONS[J]. 2021, 12(1): http://dx.doi.org/10.1038/s41467-021-24326-y.
[16] Tong, Yigang, Liu, Wenli, Liu, Peipei, Liu, William J, Wang, Qihui, Gao, George F. The origins of viruses: discovery takes time, international resources, and cooperation. LANCETnull. 2021, 398(10309): 1401-1402, http://dx.doi.org/10.1016/S0140-6736(21)02180-2.
[17] 仵丽丽, 苏佳岐, 牛胜, 陈茜, 张艳芳, 严景华, 施一, 齐建勋, 高福, 王奇慧. 新型冠状病毒结合穿山甲ACE2受体的分子机制. 科学通报[J]. 2021, 66(1): 73-84, https://nxgp.cnki.net/kcms/detail?v=3uoqIhG8C46NmWw7YpEsKMypi3qVj28LEUDxQXHYyS3fbyEOrIfBzBmBRFaMT6jP23wYg5Jq-cLBjBjjGwOxsumlyLgjCtUb&uniplatform=NZKPT.
[18] Liu, Kefang, Tan, Shuguang, Niu, Sheng, Wang, Jia, Wu, Lili, Sun, Huan, Zhang, Yanfang, Pan, Xiaoqian, Qu, Xiao, Du, Pei, Meng, Yumin, Jia, Yunfei, Chen, Qian, Deng, Chuxia, Yan, Jinghua, Wang, HongWei, Wang, Qihui, Qi, Jianxun, Gao, George Fu. Cross-species recognition of SARS-CoV-2 to bat ACE2. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2021, 118(1): http://dx.doi.org/10.1073/pnas.2020216118.
[19] Liu, Kefang, Pan, Xiaoqian, Li, Linjie, Yu, Feng, Zheng, Anqi, Du, Pei, Han, Pengcheng, Meng, Yumin, Zhang, Yanfang, Wu, Lili, Chen, Qian, Song, Chunli, Jia, Yunfei, Niu, Sheng, Lu, Dan, Qiao, Chengpeng, Chen, Zhihai, Ma, Dongli, Ma, Xiaopeng, Tan, Shuguang, Zhao, Xin, Qi, Jianxun, Gao, George F, Wang, Qihui. Binding and molecular basis of the bat coronavirus RaTG13 virus to ACE2 in humans and other species. CELL[J]. 2021, 184(13): 3438-+, http://dx.doi.org/10.1016/j.cell.2021.05.031.
[20] Wang, Qihui, Song, Hao, Cheng, Hao, Qi, Jianxun, Nam, Gol, Tan, Shuguang, Wang, Junzhi, Fang, Min, Shi, Yi, Tian, Zhigang, Cao, Xuetao, An, Zhiqiang, Yan, Jinghua, Gao, George F. Structures of the four Ig-like domain LILRB2 and the four-domain LILRB1 and HLA-G1 complex. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2020, 17(9): 966-975, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609294/.
[21] Qihui Wang. Molecular basis of binding between MERS-CoV and CD26s from seven bat species. Journal of Virology. 2020, [22] Bai, Chongzhi, Cai, Jianpiao, Han, Pengcheng, Qi, Jianxun, Yuen, KwokYung, Wang, Qihui. The crystal structure of the emerging human-infecting hepatitis E virus E2s protein. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2020, 532(1): 25-31, http://dx.doi.org/10.1016/j.bbrc.2020.07.074.
[23] Wu, Lili, Chen, Qian, Liu, Kefang, Wang, Jia, Han, Pengcheng, Zhang, Yanfang, Hu, Yu, Meng, Yumin, Pan, Xiaoqian, Qiao, Chengpeng, Tian, Siyu, Du, Pei, Song, Hao, Shi, Weifeng, Qi, Jianxun, Wang, HongWei, Yan, Jinghua, Gao, George Fu, Wang, Qihui. Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2. CELL DISCOVERY[J]. 2020, 6(1): http://dx.doi.org/10.1038/s41421-020-00210-9.
[24] Yuan, Yuan, Qi, Jianxun, Peng, Ruchao, Li, Chunrui, Lu, Guangwen, Yan, Jinghua, Wang, Qihui, Gao, George Fu. Molecular Basis of Binding between Middle East Respiratory Syndrome Coronavirus and CD26 from Seven Bat Species. JOURNAL OF VIROLOGY[J]. 2020, 94(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000514575000006.
[25] Sun, Huan, Li, Yan, Liu, Peipei, Qiao, Chengpeng, Wang, Xiaomin, Wu, Lianao, Liu, Kefang, Hu, Yu, Su, Chao, Tan, Shuguang, Zou, Shumei, Wu, Guizhen, Yan, Jinghua, Gao, George Fu, Qi, Jianxun, Wang, Qihui. Structural basis of HCoV-19 fusion core and an effective inhibition peptide against virus entry. EMERGING MICROBES & INFECTIONSnull. 2020, 9(1): 1238-1241, http://dx.doi.org/10.1080/22221751.2020.1770631.
[26] Wang, Qihui, Zhang, Yanfang, Wu, Lili, Niu, Sheng, Song, Chunli, Zhang, Zengyuan, Lu, Guangwen, Qiao, Chengpeng, Hu, Yu, Yuen, KwokYung, Wang, Qisheng, Zhou, Huan, Yan, Jinghua, Qi, Jianxun. Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2. CELL[J]. 2020, 181(4): 894-+, http://dx.doi.org/10.1016/j.cell.2020.03.045.
[27] Gary Kobinger, Trina Racine, Qihui Wang, Jinghua Yan. Isolation of Monoclonal Antibodies from Zika Virus-Infected Patient Samples. ZIKA VIRUS. 2020, 2142: 261-288, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197385/.
[28] Shi, Rui, Shan, Chao, Duan, Xiaomin, Chen, Zhihai, Liu, Peipei, Song, Jinwen, Song, Tao, Bi, Xiaoshan, Han, Chao, Wu, Lianao, Gao, Ge, Hu, Xue, Zhang, Yanan, Tong, Zhou, Huang, Weijin, Liu, William Jun, Wu, Guizhen, Zhang, Bo, Wang, Lan, Qi, Jianxun, Feng, Hui, Wang, FuSheng, Wang, Qihui, Gao, George Fu, Yuan, Zhiming, Yan, Jinghua. A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2. NATURE[J]. 2020, 584(7819): 120-+, http://dx.doi.org/10.1038/s41586-020-2381-y.
[29] Wang, Qihui, Ma, Tong, Wu, Yan, Chen, Zhihai, Zeng, Hui, Tong, Zhou, Gao, Feng, Qi, Jianxun, Zhao, Zhennan, Chai, Yan, Yang, Huabing, Wong, Gary, Bi, Yuhai, Wu, Lili, Shi, Rui, Yang, Mi, Song, Jian, Jiang, Haihai, An, Zhiqiang, Wang, Junzhi, Yilma, Tilahun D, Shi, Yi, Liu, William J, Liang, Mifang, Qin, Chuan, Gao, George F, Yan, Jinghua. Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus. NATURE MICROBIOLOGY[J]. 2019, 4(7): 1231-1241, http://www.corc.org.cn/handle/1471x/2205968.
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（ 1 ） 病原生物与宿主的相互作用, 主持, 国家级, 2020-01--2022-12
（ 2 ） 应用抗原特异记忆B细胞筛选与单细胞测序技术获得狂犬病毒治疗性抗体, 主持, 国家级, 2020-01--2023-12
（ 3 ） “个性化药物—— 疾病分子分型的普惠新药研发”专项，“肿瘤个性化药物研究”课题, 主持, 部委级, 2018-01--2019-12
（ 4 ） 重点研发计划（公共安全风险防控与应急技术装备）重点专项“新冠病毒分子溯源研究”, 参与, 国家级, 2020-04--2021-02
（ 5 ） 重点研发计划（公共安全风险防控与应急技术装备），2019-nCoV溯源与传播途径研究, 参与, 国家级, 2020-01--2020-12

（1）Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus   第二届全国病毒学青年学者学术研讨会   2017-11-07
（2）Protective antibodies against Zika and their molecular determinants   2017-03-22
（3）Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus   2017-02-25
（4）Human neutralizing antibodies isolated from a Zika patient and their molecular determinants   中国第11届免疫学大会   2016-11-04