游书力 男 汉族 博导 上海有机化学研究所

电子邮件:slyou@mail.sioc.ac.cn
联系电话: +86 21 54925085
通信地址:上海市零陵路345号中国科学院上海有机所金属有机化学国家重点实验室
邮政编码:200032

研究领域

  • 过渡金属催化的反应(新型高选择性的反应发展及应用,不对称合成的研究) 
  • 以绿色合成化学为导向的新反应方法和技术

教育背景

  • 博士学位,中科院上海有机所 导师:戴立信院士(2001)
  • 学士学位,南开大学化学系 (1996) 

工作经历

  • 2009年12月至今:中科院上海有机所金属有机国家重点实验室副主任
  • 2006年4月至今:中科院上海有机所金属有机国家重点实验室研究员
  • 2004年2月-2006年4月:Principal Investigator, Genomics Institute of the Novartis Research Foundation (GNF), San Diego, CA USA
  • 2001年9月-2004年1月:Postdoctoral fellow, Professor Jeffery W. Kelly, Department of Chemistry, The Scripps Research Institute, La Jolla, CA USA

获奖与荣誉

  • • RSC Merck Award 2015
    • 国家杰出青年科学基金结题终评优秀(2015)
    • 上海领军人才(2014)
    • WuXi PharmaTech Life Science and Chemistry Award (2014)
    • 第七届上海青年科技英才 (2014)
    • 中国化学会青年手性化学奖 (2014)
    • 2014 Roche Chinese Young Investigator Award
    •中国科学院青年科学家奖 (2014)
    • 中国科学院上海分院第三届杰出青年科技创新人才 (2014)
    • 科技部中青年科技创新领军人才(2013)
    • 国家自然科学二等奖(排名第三, 2013)“基于手性膦氮配体的不对称催化” 证书号:2013-Z-103-2-07-R03
    • 2013年度中国科学院“优秀研究生指导老师”奖
    • 中国科学院优秀导师奖 (2013)
    • Selected as “Asian Rising Stars” in 15th Asian Chemical Congress (2013)
    • 访问教授,2013年8月德国明斯特大学
    • 上海市自然科学一等奖(排名第三, 2013)“基于手性膦氮配体的不对称催化”
    • 中国科学院优秀导师奖 (2012)
    • 访问教授,2012年11-12月北海道大学
    • 2012年中国科学院研究生院BHP Billiton奖学金导师科研奖
    • Asian Core Program Lectureship Award (Japan, Singapore, 2012)
    • 阿斯利康杰出化学奖 (2011)
    • 朱李月华优秀教师奖(2011)
    • 第三届中国化学会-英国皇家化学会青年化学奖 (2011)
    • 2007年度“百人计划”入选者终期评估为优秀 (2011)
    • 国家杰出青年科学基金(2010)
    • Thieme Chemistry Journals Award (2010)
    • 中国化学会青年化学奖(2008)
    • 第一届“中美教授联合会杰出青年教授奖”(2008)
    • 中国化学会-约翰威立出版公司青年化学论文奖(2007)
    • 中国科学院百人计划(2007)
    • 全国百篇优秀博士论文(2003)
    • 中科院院长奖学金特别奖 (2001)

代表论文

•Zhang, X.; Liu, W.-B.; Tu, H.-F.; You, S.-L.* Ligand-Enabled Ir-Catalyzed Intermolecular Diastereoselective and Enantioselective Allylic Alkylation of 3-Substituted Indoles. Chem. Sci. 2015, 6, accepted.
•Zhuo, C.-X.; Cheng, Q.; Liu, W.-B.; Zhao, Q.; You, S.-L.* Enantioselective Synthesis of Pyrrole Based Spiro- and Polycyclic Derivatives by Ir-catalyzed Asymmetric Allylic Dearomatization and Controllable Migration Reactions. Angew. Chem. Int. Ed. 2015, 54, accepted.
•Li, G.-T.; Gu, Q.; You, S.-L.* Enantioselective Annulation of Enals with 2-Naphthols by Triazolium Salts Derived from L-Phenylalanine. Chem. Sci. 2015, 6, 4273-4278.
•Yin, Q.; Wang, S.-G.; Liang, X.-W.; Gao, D.-W.; Zheng, J.; You, S.-L.* Organocatalytic Asymmetric Chlorinative Dearomatization of Naphthols. Chem. Sci. 2015, 6, 4179-4183.
•Shao, W.; Li, H.; Liu, C.; Liu, C.-J.*; You, S.-L.* Copper-Catalyzed Intermolecular Asymmetric Propargylic Dearomatization of Indoles. Angew. Chem. Int. Ed. 2015, 54, 7684-7687.
•Zheng, J; Wang, S.-B.; Zheng, C.; You, S.-L.* Asymmetric Dearomatization of Naphthols via a Rh-Catalyzed C(sp2)–H Functionalization/Annulation Reaction. J. Am. Chem. Soc. 2015, 137, 4880-4883.
•Zhang, X.; Yang, Z.-P.; Huang, L.; You, S.-L.* Highly Regio- and Enantioselective Synthesis of N-Substituted 2-pyridones via Ir-Catalyzed Intermolecular Asymmetric Allylic Amination. Angew. Chem. Int. Ed. 2015, 54, 1873-1876.
•Wang, S.-G.; Yin, Q.; Zhuo, C.-X.; You, S.-L.* Asymmetric Dearomatization of β-Naphthols via Chiral Phosphoric Acid-Catalyzed Amination Reaction. Angew. Chem. Int. Ed. 2015, 54, 647-650.
•Zheng, C.*; Zhuo, C.-X.; You, S.-L.* Mechanistic Insights into the Pd-Catalyzed Intermolecular Asymmetric Allylic Dearomatization of Multisubstituted Pyrroles: Understanding the Remarkable Regio- and Enantioselectivity. J. Am. Chem. Soc. 2014, 136, 16251-16259.
•Xu, R.-Q.; Gu, Q.; Wu, W.-T.; Zhao, Z.-A.; You, S.-L.* Construction of Erythrinane Skeleton via Pd(0)-Catalyzed Intramolecular Dearomatization of para-Aminophenols J. Am. Chem. Soc. 2014, 136, 15469-15472.
•Zheng, J.; You, S.-L.* Construction of Axial Chirality via Rhodium-Catalyzed Asymmetric Dehydrogenative Heck Coupling of Biaryl Compounds with Alkenes. Angew. Chem. Int. Ed. 2014, 53, 13244-13247.
•Zhuo, C.-X.; Zheng, C.; You, S.-L.* Transition-metal-catalyzed Asymmetric Allylic Dearomatization Reactions Acc. Chem. Res. 2014, 47, 2558-2573.
•Yang, Z.-P.; Wu, Q.-F.; You, S.-L.* Direct Asymmetric Dearomatization of Pyridines and Pyrazines via Ir-Catalyzed Allylic Amination Reactions. Angew. Chem. Int. Ed. 2014, 53, 6986-6989.
•Zhuo, C.-X.; Zhou, Y.; You, S.-L.* Highly Regio- and Enantioselective Synthesis of Poly-Substituted 2H-Pyrroles via Pd-Catalyzed Intermolecular Asymmetric Allylic Dearomatization of Pyrroles J. Am. Chem. Soc. 2014, 136, 6590-6593 (selected as JACS Spotlights).
•Gao, D.-W.; Yin, Q.; Gu, Q.*; You, S.-L.* Enantioselective Synthesis of Planar Chiral Ferrocenes via Pd(0)-Catalyzed Intramolecular Direct C-H Bond Arylation J. Am. Chem. Soc. 2014, 136, 4841-4844.
•Wang, S.-G.; You, S.-L.* Cascade Hydrogenative Dearomatization of Pyridine and Asymmetric aza-Friedel-Crafts Alkylation Reaction. Angew. Chem. Int. Ed. 2014, 53, 2194-2197.
•Zhuo, C.-X.; You, S.-L.* Palladium-Catalyzed Intermolecular Asymmetric Allylic Dearomatization Reaction of Naphthol Derivatives. Angew. Chem. Int. Ed. 2013, 52, 10056-10059.
•Zhuo, C.-X.; Wu, Q.-F.; Zhao, Q.; Xu, Q.-L.; You, S.-L.* Enantioselective Functionalization of Indoles and Pyrroles via An in-situ Formed Spiro-intermediate J. Am. Chem. Soc. 2013, 135, 8169-8172.
•Gao, D.-W.; Shi, Y.-C.; Gu, Q.*; Zhao, Z.-L.; You, S.-L.* Enantioselective Synthesis of Planar Chiral Ferrocenes via Palladium-catalyzed Direct Coupling with Aryl Boronic Acids J. Am. Chem. Soc. 2013, 135, 86-89.
•Zhuo, C.-X.; Zhang, W.*; You, S.-L.* Catalytic Asymmetric Dearomatization Reactions. Angew. Chem. Int. Ed. 2012, 51, 12662-12686.
•Liu, W.-B.; Zhang, X.; Dai, L.-X.; You, S.-L.* Asymmetric N-Allylation of Indoles via Ir-Catalyzed Allylic Alkylation of Indolines and Oxidation Strategy. Angew. Chem. Int. Ed. 2012, 51, 5183-5187.
•Liu, W.-B.; Zheng, C.; Zhuo, C.-X.; Dai, L.-X.; You, S.-L.* Ir-Catalyzed Allylic Alkylation Reaction with N-Aryl Phosphoramidite Ligands: Scope and Mechanistic Studies J. Am. Chem. Soc. 2012, 134, 4812-4821.
•Zheng, C.; You, S.-L.* Transfer Hydrogenation with Hantzsch Esters and Related Organic Hydride Donors Chem. Soc. Rev. 2012, 41, 2498-2518. (invited paper)
•Wu, Q.-F.; Zheng, C.; You, S.-L.* Enantioselective Syntheses of Spiro Cyclopentane-1,3’-indoles and 2,3,4,9-Tetrahydro-1H-carbazoles via Ir-Catalyzed Allylic Dearomatization and Stereospecific Migration. Angew. Chem. Int. Ed. 2012, 51, 1680-1683.
•Ye, K.-Y.; He, H.; Liu, W.-B.; Helmchen, G.; Dai, L-X.; You, S.-L.* Iridium-Catalyzed Allylic Vinylation and Asymmetric Allylic Amination Reactions with ortho-Aminostyrenes J. Am. Chem. Soc. 2011, 133, 19006-19014.
•Cai, Q.; Zheng, C.; Zhang, J.-W.; You, S.-L.* Enantioselective Michael-Mannich Polycyclization Cascade of Indolyl Enones by Quinine-Derived Primary Amine Angew. Chem. Int. Ed. 2011, 50, 8665-8669.
•Wu, Q.-F.; Liu, W.-B.; Zhuo, C.-X.; Rong, Z.-Q.; Ye, K.-Y.; You, S.-L.* Ir-Catalyzed Intramolecular Asymmetric Allylic Dearomatization of Phenols. Angew. Chem. Int. Ed. 2011, 50, 4455-4458.
•Cai, Q.; Zheng, C.; You, S.-L.* Chiral Phosphoric Acid-Catalyzed Enantioselective Intramolecular Aza-Michael Addition of Indoles Angew. Chem. Int. Ed. 2010, 49, 8666-8669.
•Wu, Q.-F.; He, H.; Liu, W.-B.; You, S.-L.* Enantioselective Construction of Spiroindolenines by Ir-Catalyzed Allylic Alkylation Reactions J. Am. Chem. Soc. 2010, 132, 11418-11419.
•Peng, H. M.; Dai, L.-X.; You, S.-L.* Enantioselective Palladium-Catalyzed Direct Alkylation and Olefination Reaction of Simple Arenes Angew. Chem. Int. Ed. 2010, 49, 5826-5828. (Highlights)
•He, H.; Liu, W.-B.; Dai, L.-X.; You, S.-L.* Enantioselective Synthesis of 2,3-Dihydro-1H-benzo[b]azepines via Ir-Catalyzed Tandem Allylic Vinylation/Amination Reaction. Angew. Chem. Int. Ed. 2010, 49, 1496-1499.
•Gu, Q.; Rong, Z.-Q.; Zheng, C.; You, S.-L.* Desymmetrization of Cyclohexadienones via Brønsted Acid-Catalyzed Enantioselective Oxo-Michael Reaction J. Am. Chem. Soc. 2010, 132, 4056-4057.
•Cai, Q.; Zhao, Z.-A.; You, S.-L.* Asymmetric Construction of Polycyclic Indoles through Olefin Cross-Metathesis/ Intramolecular Friedel-Crafts Alkylation under Sequential Catalysis. Angew. Chem. Int. Ed. 2009, 48, 7428-7431.
•He, H.; Liu, W.-B.; Dai, L.-X.; You, S.-L.* Ir-Catalyzed Cross-Coupling of Styrene Derivatives with Allylic Carbonates: Free Amine Assisted Vinyl C-H Bond Activation J. Am. Chem. Soc. 2009, 131, 8346-8347.
•You, S.-L.*; Cai, Q.; Zeng, M. Chiral Brønsted Acids Catalyzed Friedel-Crafts Alkylation Reaction Chem. Soc. Rev. 2009, 38, 2190-2201. (invited review)
•Kang, Q.; Zhao, Z.-A.; You, S.-L.* Highly Enantioselective Friedel-Crafts Reaction of Indoles with Imines by a Chiral Phosphoric Acid. J. Am. Chem. Soc. 2007, 129, 1484-1485.
•Xia, J.-B.; You, S.-L.* Carbon-Carbon Bond Formation through Double sp2 C-H Activations: Synthesis of Ferrocenyl Oxazoline Derivatives. Organometallics 2007, 26, 4869-4871.
•You, S.-L.*; Dai, L.-X. Enantioselective Palladium-Catalyzed Decarboxylative Allylic Alkylations. Angew. Chem. Int. Ed. 2006, 45, 5246-5248. (Highlights)

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