Structure-and-function of the ion channels/synaptic proteins

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2002.9-2006.6 Zhejiang University of Technology (ZJUT), BSc student;

2006.9-2009.6 East China Normal University (ECNU), Shanghai Key Laboratory of Brain Functional Genomics, MSc student;

2009.9-2013.9 Institut de Biologie de l’Ecole Normale Supérieure, France, PhD student.

1.Zhu S, Gouaux E.(2017). Structure and symmetry inform gating principles of ionotropic glutamate receptors.(Invited review, Cover). Neuropharmacol. 2017 Jan;112(Pt A):11-15.

2.Zhu S, Stein RA, Yoshioka C, Lee CH, Goehring A, Mchaourab HS, Gouaux E. (2016).Mechanism of NMDA receptor inhibition and activation.Cell. 165 (3), 704-714

3.Zhu S, Paoletti P.(2015). Allosteric modulators of NMDA receptors: multiple sites and mechanisms. Curr Opin Pharmacol. (Invited review). Nov 12;20C:14-23.

4.Zhu S*, Riou M*, Yao A, Carvalho S, Rodriguez P, Bensaude O, Paoletti P# & Ye S#. (2014). Genetically encoding a light-switch in an ionotropic glutamate receptor reveals subunit-specific interfaces. Proc Natl Acad Sci U S A. Apr 22;111(16):6081-6. * co-1st author, #co-senior author.

5.Stroebel D, Carvalho S, Grand T, Zhu S, Paoletti P. (2014). Controlling NMDA Receptor Subunit Composition Using Ectopic Retention Signals. J Neurosci. Dec 10;34(50):16630-6.

6.Zhu S, Stroebel D, C.Andrea Y, Taly A, Paoletti P. (2013). Allosteric signaling and dynamics of the clamshell-like NMDA receptor GluN1 N-terminal domain.Nat. Struct. Mol. Biol. 20, 477–485.

7.Mony L, Zhu S, Carvalho S, Paoletti P. (2011). Molecular basis of positive allosteric modulation of GluN2B NMDA receptors by polyamines.EMBO J. 30(15): 3134-3146.

8.Meng B, Zhu S, Li S, Zeng Q, Mei B. (2009). Global view of the mechanisms of improved learning and memory capability in mice with music-exposure by microarray.Brain Res Bull. Aug 28; 80(1-2):36-44.

现指导学生

李伟  博士研究生  071006-神经生物学  

章彤彤  硕士研究生  071006-神经生物学  

Excellent Graduate Student of Zhejiang University of Technology, 2006

The outstanding Graduate Scholarship of East China Normal University, 2008

PhD scholarship, China Scholarship Council, 2009.9-2012.8

Labex poster award, 23rd Ion Channel Meeting, Presqu'île de Giens – France, 2012

Fondation pour la Recherche Médicale (FRM) award, for 4^th year PhD, France, 2012-2013

Cold Spring Harbor Asia fellowship, Membrane Protein Structure & Function Meeting, 2013

Received highest academic distinction of PhD thesis “Très honorable” in France, 2013.9

Labex Memolife, Post-doctoral fellowship. 2014.1-2014.5

2013.10-2014.5 Institut de Biologie de l’Ecole Normale Supérieure, Postdoctoral fellow;

2014.6-2016.7 Oregon Health & Science University, Vollum Institute, Postdoctoral fellow; 

2016.8-present Institute of Neuroscience, Chinese Academy of Sciences, Principal Investigator.