1. Nanomedicine development for cancer diagnosis and treatment

2. Tumor targeted molecular probe design

Nov. 2008 - Sep. 2012 Max Planck Institute for Biological Cybernetics, Germany

Ph. D in Neurochemical Analysis by research in the Department of Physiology of Cognitive Processes.   

Sep. 2004 - Jul. 2007 Shenyang Pharmaceutical University, China

Master in Pharmaceutical Analysis by research in in the Department of Pharmaceutical Analysis, School of Pharmacy.

Sep. 2000 - Jul. 2004 Shenyang Pharmaceutical University, China

Bachelor in Pharmaceutical Chemistry by study in the Department of Chemical Pharmaceutics, School of Pharmaceutical Engineering.

Jan. 2019 – present Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences, China

Professor in Cixi Institute of Biomedical Engineering

Dec. 2014 – Dec. 2018 Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences, China

Associate Professor in Nano Biomaterials Group in the Department of Functional Materials and NanoDevices

Sep. 2012 – Nov.2014 Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences, China

Assistant Professor in Nano Biomaterials Group in the Department of Functional Materials and NanoDevices

1. Zhenqi Jiang(#), Yinjie Wang(#), Li Sun, Bo Yuan, Yuchen Tian, Lingchao Xiang, Yanying Li, Yong Li, Juan Li(*), Aiguo Wu(*), Dual ATP and pH responsive ZIF-90 nanosystem with favorable biocompatibility and facile post-modification improves therapeutic outcomes of triple negative breast cancer in vivo, Biomaterials, 2019, 197: 41-50.

2. Zhenqi Jiang(#), Yuchen Tian(#), Dingying Shan, Yinjie Wang, Ethan Gerhard, Jianbi Xia, Rong Huang, Yan He, Aiguo Li, Jianchao Tang, Huimin Ruan, Yong Li, Jian Yang, Juan Li (*), Aiguo Wu (*), pH protective Y₁ receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time, Biomaterials, 2018, 170: 70-81.

3. Juan Li(#), Yang Du(#), Zhenqi Jiang, Yuchen Tian, Nianxiang Qiu, Yinjie Wang, Muhammad Zubair lqbal, Menying Hu, Ruifen Zou, Lijia Luo, Shiyu Du, Jie Tian(*), Aiguo Wu(*), Y₁ receptor ligand-based nanomicelle as a novel nanoprobe for glioma-targeted imaging and therapy, Nanoscale, 2018,10: 5845-5851. 

4. Zhangsen Yu, Yuanzhi Xia, Jie Xing, Zihou Li, Jianjun Zhen, Yinhua Jin, Yuchen Tian, Chuang Liu, Zhenqi Jiang, Juan Li(*), Aiguo Wu(*), Y₁-receptor-ligand-functionalized ultrasmall upconversion nanoparticles for tumor targeted trimodality imaging and photodynamic therapy with low toxicity, Nanoscale, 2018, 10：17038-17052.

5. Juan Li(#), Yuchen Tian(#), Dingying Shan, An Gong, Leyong Zeng, Wenzhi Ren, Lingchao Xiang, Ethan Gerhard, Jinshun Zhao, Jian Yang and Aiguo Wu(*). Neuropeptide Y Y₁ receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging. Biomaterials, 2017, 116: 106-117.

6. Juan Li, Zheyu Shen, Xuehua Ma, Wenzhi Ren, Lingchao Xiang, An Gong, Tian Xia, Junming Guo, Aiguo Wu(*). Neuropeptide Y Y₁ receptors meditate targeted delivery of anticancer drug with encapsulated nanoparticles to breast cancer cells with high selectivity and its potential for breast cancer therapy. ACS Applied Materials & Interfaces 2015, 7: 5574-5582.

7. Juan Li(*), Yuchen Tian, Aiguo Wu(*). Neuropeptide Y receptors: a promising target for cancer imaging and therapy. Regenerative Biomaterials, 2015, 215-219 (Invited review)

8. Juan Li, Zheyu Shen, Xuehua Ma, Wenzhi Ren, Lingchao Xiang, An Gong, Tian Xia, Junming Guo, Aiguo Wu(*). Neuropeptide Y Y1 receptors mediate targeted delivery nanoparticles for breast cancer therapy. Neuropeptides, 2016, 55: 7-8.

9. Tang Lin, Zhenqi Jiang, Juan Li(*), Aiguo Wu(*).Study on anti-glioma active compounds and their nanomicelles preparation of the Root of Actinidiaeriantha Benth, Chemical Journal of Chinese Universities, 2019, 40: 468-472.

10. Hong Su, Xin Song, Juan Li, Muhammad Zubair Iqbal, Samuel Selorm Fiati Kenston, Zhen Li, Aiguo Wu, Min Ding, Jinshun Zhao(*), Biosafety evaluation of Janus Fe3O4-TiO2 nanoparticles in Sprague Dawley rats after intravenous injection, International Journal of Nanomedicine, 2018, 13: 6987-7001.

11. Hong Su, Zhou Li, Lissy Lazar, Yasmin Alhamoud, Xin Song, Juan Li, Yafei Wang, Samuel Selorm Fiati kenston, Muhammad Zubair Lqbal, Aiguo Wu, Zhen Li, Qihang Hua, Min Ding, Jinshun Zhao, In vitro evaluation of the toxicity and underlying molecular mechanisms of Janus Fe3O4-TiO2 nanoparticles in human liver cells, Environmental Toxicology, 2018, 33: 1078-1088.

12. Xiaoxia Wu, Yuanzhi Xia, Youju Huang, Juan Li, Huimin Ruan, Tianxiang Chen, Liqiang Luo, Zheyu Shen*, Aiguo Wu*, Improved SERS-Active Nanoparticles with Various Shapes for CTC Detection without Enrichment Process with Supersensitivity and High Specificity. ACS Applied Materials ＆ Interfaces, 2016, 8: 19928-19938.

13. Xiaoxia Wu, Yuanzhi Xia, Youju Huang, Juan Li, Huimin Ruan, Tianxiang Chen, Liqiang Luo, Zheyu Shen*, Aiguo Wu*. Improved SERS-Active Nanoparticles with Various Shapes for CTC Detection without Enrichment Process with Supersensitivity and High Specificity. ACS Appl. Mater. Interfaces, 2016, 8 (31): 19928–19938. (IF=7.504)

14. Juan Li(#), Veronika von Pföstl(#), Daniel Zaldivar, Xiaozhe Zhang, Nikos Logothetis and Alexander Rauch. Measuring multiple neurochemicals and related metabolites in blood and brain of the rhesus monkey by using dual microdialysis sampling and capillary hydrophilic interaction chromatography-mass spectrometry. Analytical Bioanalytical Chemistry, 2011, 402: 2545-54.

15. Veronika von Pföstl (#), Juan Li (#), Daniel Zaldivar, Xiaozhe Zhang, Nikos Logothetis and Alexander Rauch. Effects of lactate on the early visual cortex of non-human primates, investigated by pharmaco-MRI and neurochemical analysis. NeuroImage, 2012, 61: 98-105.

My interests maily foucus on the application of nanobiomaterials in targeted cancer therapy and diagnosis.

1. Juan Li, Aiguo Wu. Neuropeptide Y-nanoprobe for targeted tumor imaging and therapy. The Westlake International Forum on Ultrasound in Biomedicine and Biology, Hangzhou, China, 2019. 03.08, Invited Talk

2. Juan Li, Aiguo Wu. Neuropeptide Y-nanosystem for targeted tumor imaging and therapy. Zhenzhou, China, 2018.10.27, Talk

3. Juan Li, Aiguo Wu. Neuropeptide Y₁ ligands-based nanomedicine for targeted tumor imaging and therapy. Frist Electroanalytical Chemistry Symposium & One Belt and One Road International Collaboration Workshop of CAS, Ningbo, China, 2018.05.02-04, Talk

4. Juan Li. Neuropeptide Y₁R ligands-based nanomedicine for targeted tumor imaging and therapy. ChinaNanomedicine 2018, Shanghai, China, 2018.10.15-17, Invited Talk

5. Juan Li, Aiguo Wu. Neuropeptide Y-nanoprobe for targeted tumor imaging and therapy. The 10th National Low-field Nuclear Magnetic Resonance Technology and Application Seminar, Ningbo, China, 2018.11.06, Talk

6. Juan Li, Aiguo Wu. Neuropeptide Y1 receptor ligands-based nanomedicine for targeted tumor imaging and therapy. XIV International Conference on Nanostructured Materials, Hongkong, China, 2018.06.24-29, Talk.

7. Juan Li, Yuchen Tian, Dingying Shan, Jian Yang, Aiguo Wu. Y₁ receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging. 2017 CASNN Annual Meeting, Suzhou, China, 2017.07.29-31, Poster

8. Juan Li, Yuchen Tian, Dingying Shan, An Gong, Leyong Zeng, Wenzhi Ren, Lingchao Xiang, Ethan Gerhard, Jinshun Zhao, Jian Yang, Aiguo Wu. Neuropeptide Y Y₁ receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging, The 2nd International Symposium on Translational Nanomedicine, Guangzhou, China, 2017.01.05-07, Poster

9. Juan Li, Yuchen Tian, Aiguo Wu. Neuropeptide Y Y1 receptors-based nanoparticulate delivery system for targeted imaging and therapy of breast cancer. 10th World Biomaterials Congress (WBC2016), Montreal, Canada, 2016.05.17-22, Poster

10. Juan Li, Yuchen Tian, Dingying Shan, Mengying Hu, Lingchao Xiang, Jian Yang, Aiguo Wu. Y1 receptor-mediated nanoparticles for targeted breast cancer imaging and therapy. Precision Nanomedicine Symposium 2016, Beijing, China, 2016.07.08-11, Poster

11. Juan Li, Neuropeptide Y receptors: a promising target for breat cancer imaging and therapy. 2nd China-Germany Nanobiomaterials Symposium, Ningbo, China, 2016.11.13-14, Talk

12. Juan Li, Zheyu Shen, Xuehua Ma, Wenzhi Ren, Lingchao Xiang, An Gong, Tian Xia, Junming Guo, Aiguo Wu*. Neuropeptide Y Y1 receptors mediate targeted delivery of anticancer drug encapsulating nanoparticles for breast cancer therapy. 5th China Europe Symposium on Biomaterials in Regenerative Medicine (CESB2015), Hangzhou, China, 2015.04.04-10, Talk

13. Juan Li, Daniel Zaldivar, Veronika von Pföstl, Xiaozhe Zhang, Nikos Logothetis and Alexander Rauch. Targeted tissue sampling and imaging in non-human primates brain with microdialysis and fMRI. European Summit for Clinical Nanomedicine (CLINAM 2012), Basel, Switzerland

14. Daniel Zaldivar, Juan Li, Veronika von Pföstl, Kevin Whittingstall, Jozien Goense, Alexander Rauch and Nikos Logothetis. The modulatory role of dopamine in the early visual system of macaques investigated by fMRI, neurochemistry and neurophysiology. 8th Forum of European Neuroscience (FENS 2012), Barcelona, Spain

15. Veronika von Pföstl, Daniel Zaldivar, Juan Li, Sneha Viswanath, Xiaozhe Zhang, Nikos Logothetis and Alexander Rauch. Electrophysiological effects of lactate on primary visual cortex of non-human primates. 8th Forum of European Neuroscience (FENS 2012), Barcelona, Spain.

16. Juan Li, Daniel Zaldivar, Veronika von Pföstl, Nadine Serr, Xiaozhe Zhang, Nikos Logothetis and Alexander Rauch. Nicotinic modulation of the early visual system and its underlying neuronal and metabolic changes. 41st Annual Meeting of the Society for Neuroscience (Neuroscience 2011), Washington DC, USA

17. Daniel Zaldivar, Juan Li, Veronika von Pföstl, Xiaozhe Zhang, Nikos Logothetis and Alexander Rauch. Dopaminergic modulation of the early visual system of non-human primates and its underlying neuronal and hemodynamic changes. 41st Annual Meeting of the Society for Neuroscience (Neuroscience 2011), Washington DC, USA

18. Juan Li, Veronika von Pföstl, Daniel Zaldivar, Xiaozhe Zhang, Nikos Logothetis and Alexander Rauch. Comparing concentration levels of multiple neurochemically active compounds in blood and brain tissue of non-human primates by using dual microdialysis sampling and capillary hydrophilic interaction chromatography-mass spectrometry. 40th Annual Meeting of the Society for Neuroscience (Neuroscience 2010), San Diego, USA

19. Veronika von Pföstl, Juan Li, Daniel Zaldivar, Jozien Goense, Xiaozhe Zhang, Nikos Logothetis and Alexander Rauch. Effects of Lactate on primary visual cortex of non-human primates investigated by pharmaco MRI and Neurochemical Analysis. 40th Annual Meeting of the Society for Neuroscience (Neuroscience 2010), San Diego, USA

20. Xiaozhe Zhang, Alexander Rauch, Anwesha Bhattacharyya, Juan Li, Gregor Rainer and Nikos Logothetis. Determining neurochemicals from the non-human primate brain by using capillary hydrophilic interaction chromatography-mass spectrometry. International Mass Spectrometry Conference (IMSC 2009), Bremen, Germany

Best Young Scientist for CESB 2015

Max Plank Scholarship during PhD study

Best Master Thesis during graduate study

Xinyi Scholarship during graduate study

People Scholarship during undergraduate study

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