1. 新型荧光染料的开发及构效关系研究

2. 复杂体系(活细胞、材料等）动态超分辨荧光成像

3. 高灵敏度荧光探针设计

   

070302-分析化学

活细胞内超分辨荧光成像，荧光染料与探针开发

2012-09--2018-04   大连理工大学   博士
2008-09--2012-06   大连理工大学   学士

   

2020-07~现在, 中国科学院大连化学物理研究所, 副研究员
2018-07~2020-06,中国科学院大连化学物理研究所, 助理研究员

   

（1） “国科大杯”创新创业大赛, 三等奖, 院级, 2019
（2） 辽宁省自然科学学术成果奖, 三等奖, 省级, 2018
（3） 中国分析测试协会科学技术奖, 二等奖, 专项, 2018

   

（1） Aniline as a TICT rotor to derive methine fluorogens for biomolecules: A curcuminoid-BF2 compound for lighting up HSA/BSA, CHINESE CHEMICAL LETTERS, 2023, 通讯作者
（2） Dye disaggregation light-up aptamer for super-resolution RNA imaging, SENSORS AND ACTUATORS: B. CHEMICAL, 2023, 通讯作者
（3） Modulation of dynamic aggregation in fluorogenic SNAP‐tag probes for long‐term super‐resolution imaging, AGGREGATE, 2023, 第 1 作者
（4） Cellular membrane imaging of the dynamic binding-dissociation of rhodamine-benzenesulfonamide bioconjugate with carbonic anhydrase IX for inhibitor screening, SENSORS AND ACTUATORS: B. CHEMICAL, 2023, 通讯作者
（5） In Situ Real-Time Nanoscale Resolution of Structural Evolution and Dynamics of Fluorescent Self-Assemblies by Super-Resolution Imaging, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 第 1 作者
（6） An Acid-Regulated Self-Blinking Fluorescent Probe for Resolving Whole-Cell Lysosomes with Long-Term Nanoscopy, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 第 1 作者
（7） Enhancing Brightness and Photostability of Organic Small Molecular Fluorescent Dyes Through Inhibiting Twisted Intramolecular Charge Transfer (TICT), ACTA CHIMICA SINICA, 2022, 通讯作者
（8） Systematic study of synthesizing various heteroatom-substituted rhodamines from diaryl ether analogues, SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2020, 通讯作者
（9） Quantitative Design of Bright Fluorophores and AIEgens by the Accurate Prediction of Twisted Intramolecular Charge Transfer (TICT), ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 第 2 作者
（10） Descriptor Delta G(C-O)Enables the Quantitative Design of Spontaneously Blinking Rhodamines for Live-Cell Super-Resolution Imaging, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 第 2 作者
（11） Long-term super-resolution imaging of mitochondrial dynamics, Long-term super-resolution imaging of mitochondrial dynamics, CHINESE CHEMICAL LETTERS, 2020, 通讯作者
（12） A Photoexcitation-Induced Twisted Intramolecular Charge Shuttle, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 第 2 作者
（13） A general strategy to develop cell membrane fluorescent probes with location- and target-specific fluorogenicities: a case of a Zn2+ probe with cellular selectivity, CHEMICAL COMMUNICATIONS, 2019, 通讯作者
（14） Combined application of SNAP-tag and fluorescence technique in in-situ protein analysis, CHINESE JOURNAL OF CHROMATOGRAPHY, 2019, 第 1 作者
（15） Strong π-π stacking interactions led to the mis-assignment of dimer emissions to the monomers of 1-acetylpyrene, CHINESECHEMICALLETTERS, 2019, 通讯作者
（16） A wash-free SNAP-tag fluorogenic probe based on the additive effects of quencher release and environmental sensitivity, CHEMICAL COMMUNICATIONS, 2017, 第 2 作者
（17） A naphthalimide-derived fluorogenic probe for SNAP-tag with a fast record labeling rate, DYES AND PIGMENTS, 2017, 第 1 作者
（18） Aziridinyl fluorophores demonstrate bright fluorescence and superior photostability by effectively inhibiting twisted intramolecular charge transfer, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016, 第 2 作者
（19） A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells, RSC ADVANCES, 2014, 第 1 作者
（20） Constructing D-π-A-π dye to obtain red-emission fluorescent probe for structured illumination microscopy imaging of lipid droplet dynamics, GREEN CHEMICAL ENGINEERING, 第 5 作者

（1） 荧光染料及其生物医学应用, 化学工业出版社, 2022-03, 第 其他 作者